GenomeNet

Database: Pfam
Entry: DUF2250
LinkDB: DUF2250
Original site: DUF2250 
#=GF ID   DUF2250
#=GF AC   PF10007.6
#=GF DE   Uncharacterized protein conserved in archaea (DUF2250)
#=GF AU   COGs, Finn RD, Sammut SJ
#=GF SE   COGs (COG4344)
#=GF GA   24.40 24.40;
#=GF TC   24.40 24.40;
#=GF NC   24.20 24.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR019254;
#=GF CC   Members of this family of hypothetical archaeal proteins have no
#=GF CC   known function.
#=GF SQ   56
#=GS C8VZV7_DESAS/117-207  AC C8VZV7.1
#=GS Q5JG76_THEKO/14-106   AC Q5JG76.1
#=GS F2KN95_ARCVS/3-108    AC F2KN95.1
#=GS A4YIE5_METS5/111-203  AC A4YIE5.1
#=GS A4YIE5_METS5/9-101    AC A4YIE5.1
#=GS L0ABP7_CALLD/119-211  AC L0ABP7.1
#=GS F0S2Q3_DESTD/6-97     AC F0S2Q3.1
#=GS T0M8J2_9EURY/7-99     AC T0M8J2.1
#=GS L0AIU2_NATGS/193-278  AC L0AIU2.1
#=GS F4B6B1_ACIHW/111-203  AC F4B6B1.1
#=GS G4RM81_THETK/1-93     AC G4RM81.1
#=GS A8M9U9_CALMQ/1-92     AC A8M9U9.1
#=GS Q6KZK1_PICTO/7-99     AC Q6KZK1.1
#=GS Q96YS5_SULTO/9-101    AC Q96YS5.1
#=GS D9PZR9_ACIS3/3-96     AC D9PZR9.1
#=GS C5CEI2_KOSOT/7-92     AC C5CEI2.1
#=GS D2REQ1_ARCPA/2-90     AC D2REQ1.1
#=GS W0K247_9EURY/9-78     AC W0K247.1
#=GS Q96YS5_SULTO/111-203  AC Q96YS5.1
#=GS T0M289_9EURY/11-103   AC T0M289.1
#=GS F2KN96_ARCVS/106-198  AC F2KN96.1
#=GS G0EFH4_PYRF1/123-214  AC G0EFH4.1
#=GS L0JY40_9EURY/193-277  AC L0JY40.1
#=GS W0JFB7_DESAE/2-90     AC W0JFB7.1
#=GS Q18IX1_HALWD/94-186   AC Q18IX1.1
#=GS G4RPG1_THETK/1-102    AC G4RPG1.1
#=GS L0JY40_9EURY/94-186   AC L0JY40.1
#=GS G0EFH4_PYRF1/224-316  AC G0EFH4.1
#=GS Q4J7U2_SULAC/5-97     AC Q4J7U2.1
#=GS A4XK03_CALS8/3-93     AC A4XK03.1
#=GS N0BGN4_9EURY/5-111    AC N0BGN4.1
#=GS B4U7S4_HYDS0/7-99     AC B4U7S4.1
#=GS F8I8R4_SULAT/46-80    AC F8I8R4.1
#=GS N0BK51_9EURY/102-194  AC N0BK51.1
#=GS Q18IX1_HALWD/193-285  AC Q18IX1.1
#=GS L0AIU2_NATGS/94-186   AC L0AIU2.1
#=GS G4RNA2_THETK/15-90    AC G4RNA2.1
#=GS N0BK51_9EURY/2-94     AC N0BK51.1
#=GS F2KN96_ARCVS/6-98     AC F2KN96.1
#=GS F4B6B1_ACIHW/9-101    AC F4B6B1.1
#=GS Q96YZ2_SULTO/1-106    AC Q96YZ2.1
#=GS Q3IPF0_NATPD/10-83    AC Q3IPF0.1
#=GS F8A7Z5_THEID/6-92     AC F8A7Z5.1
#=GS E1QSW4_VULDI/2-92     AC E1QSW4.1
#=GS F6DSP3_DESRL/107-212  AC F6DSP3.1
#=GS L0ABP7_CALLD/16-108   AC L0ABP7.1
#=GS D9PZR9_ACIS3/107-199  AC D9PZR9.1
#=GS Q9HLB2_THEAC/8-100    AC Q9HLB2.1
#=GS T0LX01_9EURY/11-103   AC T0LX01.1
#=GS D3TC09_ACIB4/1-90     AC D3TC09.1
#=GS Q6KZT6_PICTO/12-111   AC Q6KZT6.1
#=GS Q97WF9_SULSO/113-205  AC Q97WF9.1
#=GS Q4J7U2_SULAC/107-199  AC Q4J7U2.1
#=GS C9R7Q1_AMMDK/4-94     AC C9R7Q1.1
#=GS G0EFH4_PYRF1/2-106    AC G0EFH4.1
#=GS Q97WF9_SULSO/11-103   AC Q97WF9.1
C8VZV7_DESAS/117-207             .................ld--EEIEDEKDMQILTFLDYA.GAEY.AWRLGI.....N.....I........GIDVVE.....ARERLERLLEKGLLEK.VQ.GT.........ML.ENY.....HR.......AK..-.......-DWTK.HM.NHTYYRISRQGKHYLRQL.........................
Q5JG76_THEKO/14-106              .................yr--GLELLPVHLYVLAHLKKA.GVDY.AKMMVK.....M.....S........ELPLSL.....IEDAIRDLMEAGLVER.DS.GS.........AI.KRS.....KA.......RF..K.......KAFEV.HK.HHTYYRLSREGELFVRRI.........................
F2KN95_ARCVS/3-108               ..............peenl------DDLSRRVLLHLLIF.GPDT.PKLMGKrllgeR.....T........NIDPPN.....IKEVCIKLCEMGLVKR.RD.GK.........TLpKRT.....PTssikpwiKI..K......aKSKET.AK.HGQYFELTKEGKKVAK--av.......................
A4YIE5_METS5/111-203             ..................i-EYLQGDELALNIVRLAEEL.NADH.ALTYAK.....L.....T........KKDLEE.....VNSKLEQLVKMGLLEE.VN.AK.........II.KFG.....DR.......KS..K.......PKKET.RT.HHKYYGLTRIGELTVREM.........................
A4YIE5_METS5/9-101               ..................l-KKLIEDKRYLMVLQHLRKA.NVDY.GKSIML.....N.....T........KIPIEE.....VVIILDKLENLGLIER.VK.GA.........TL.KNT.....EA.......KF..K.......LSSEV.HK.HHTYYSLTRAGDHLLRY-l........................
L0ABP7_CALLD/119-211             .................fk--KITNYDNTLKLLIFLRKA.ENEH.AGTIVK.....V.....F........GLDMDK.....TINILEKLENLGLVIP.VK.EK.........II.KAK.....HR.......KA..K.......PKEET.RT.HHIYYRITRLTEMILRY-s........................
F0S2Q3_DESTD/6-97                ...............kskr----ILDELDIKILYYIYKV.GPAY.IKKLCQ.....R.....L........QEDFDI.....IRKHIKKLEQLGYLER.VS.GR.........IV.EYR.....I-.......DR..K.......NKVTK.HR.NHTYYNVTRKGRHFIRN-i........................
T0M8J2_9EURY/7-99                ................kkm---LAMNHEMLMVLEHFQLA.KLDY.AKNIKI.....Y.....T........SIPQGN.....VQIYIERLYSMGLIEK.YS.GS.........SV.KRT.....QA.......KL..K.......KTNEV.HK.HHTYYEITNKGHYILKDM.........................
L0AIU2_NATGS/193-278             ..................v-NVLRQLPDGHAIVQRLARI.GSDS.PRATAA.....E.....W........EMKFED.....VRHLYRALRRVGLVTQ.YD.GE.........PG.NDQ.....AQ.......S-..-.......-----.AT.DRTYYTTTAAGNDV----leav.....................
F4B6B1_ACIHW/111-203             .................id--LVKNDDLAKDILRLAEEL.NADH.ALTYAK.....L.....T........HKTLEE.....VTPKLEELERMGLLEE.AK.AK.........II.KFG.....DR.......KS..K.......PKKET.RT.HHKYYGLSRIGELVVREM.........................
G4RM81_THETK/1-93                .................mk--DVLRKKLYIDILFHLKRA.YIDY.GKSIAK.....N.....L........RVDLSE.....VIDALERLEELGLIER.VG.GH.........TL.KRS.....KA.......RF..K.......LSNEV.RK.HHIYYKLSRAGELLLRE-v........................
A8M9U9_CALMQ/1-92                ...............mnel------TDKDIAVLVHLKKA.NVDY.GKSIAL.....N.....T........GIPLQE.....VLQILDKLEYMGLVER.VKgGK.........TL.KRS.....VA.......RF..K.......LSSEV.RR.HHVYYRLSRSGELLIRA-s........................
Q6KZK1_PICTO/7-99                ..................k-RRLIENNEMLTVLEHFQVA.KVDY.AKNIMR.....Y.....T........EIPKMK.....ISHYLGILYDMGLLEK.YT.NT.........SI.KRT.....DA.......KL..K.......KSAEV.HK.HHTYYQMTNKAHYILKDL.........................
Q96YS5_SULTO/9-101               ................lle---ILKDKRMLEILKHLKKA.NVDY.GKSIML.....N.....T........KIPIQE.....VVDLLDKLEKIGLIER.VH.GA.........TL.KNT.....EA.......KF..K.......LSKEV.HK.HHTYYKLTREGDHLLRQL.........................
D9PZR9_ACIS3/3-96                ..............sklms-----LSPLSLYILFHLKKA.NVDY.AGSISK.....V.....I........EVPIDK.....VVDELDRLEAAGLIQRrVG.GS.........SI.KRS.....EA.......RF..K.......LSDEV.HK.HHVYYELSREGEGLVRSL.........................
C5CEI2_KOSOT/7-92                ................eil------EEEDWKILKDLYST.APDC.AKFLSR.....R.....L........RLDLGE.....TMRRLRTLESKGFLER.VE.GR.........FL.KKK.....GL.......R-..-.......--KPK.HM.NHTYYELTRPARLYLRKI.........................
D2REQ1_ARCPA/2-90                ...............qffp--------IHLYILLHLKRA.NVNY.VKMIAK.....M.....I........ELSLEL.....VKTALDDLMKAGLVER.DQ.GS.........AL.KRS.....KA.......KF..K.......KAFEV.RK.HHTYYKLSREGDLLVRRI.........................
W0K247_9EURY/9-78                ............ptwsrpa---------DRDIIEFLDER.GAEY.PAIVAN.....R.....I........GMHAPY.....VETRCAELAERGLLEA.VS.GE.........VV.YR-.....--.......--..-.......-----.--.------------------ltdagerace...............
Q96YS5_SULTO/111-203             ..................i-DLVKNDQMAIDILKIADEV.NADH.ALTYAK.....L.....L........HKPLEE.....VTPKLEELERTGLLEE.KN.AK.........II.KFI.....DR.......RS..K.......PKKET.RT.HHKYYGLSRIGELVVREM.........................
T0M289_9EURY/11-103              ..................l-KEVLSSHEMLKVLRHMHTA.KVDY.AKNTTR.....Y.....T........DIPQIR.....VTEYLLRLRSLGLLDT.YE.NT.........SI.KRT.....AA.......KL..K.......KSAEV.HK.HHTYFQINRSGDILLKK-a........................
F2KN96_ARCVS/106-198             ................lah---LTGCNVTFPILQFFRMA.GCEH.AGVVAR.....A.....F........SMRIDE.....CRELLAKLVQLGLLVY.CD.SK.........VL.KRK.....HR.......KA..K.......AKKET.RT.HHRYYRLSRLAEMLLRY-a........................
G0EFH4_PYRF1/123-214             ...............vlls-----LSPLHTYILLHLRMT.CTDY.AKSIAR.....T.....V........KMPIED.....VVLTLDRLEELGLIER.VH.GS.........AL.KRT.....EA.......KL..K.......LSHEV.RK.HHTYYKLSRSGEMLVRS-v........................
L0JY40_9EURY/193-277             ..................v-NVLRHLPNGRTIVQRLAHT.GPDS.PRAIAA.....E.....W........GTEFEY.....VRHLCRVLRRVGLVAQ.CD.SG.........PV.---.....--.......--..-.......-----.--.------------------dgegrsadrmyymatetgddvleav
W0JFB7_DESAE/2-90                ................cdl------NDLEIEVLKYHKQK.GCDY.SKSLAK.....A.....L........NIKLCE.....AFKVHKKLLELGYLEK.VK.SR.........FT.KYK.....-I.......DN..K.......TKLIK.HR.NHTYYQLSHNGKQFLKEL.........................
Q18IX1_HALWD/94-186              ................lap---LPVTPVAYLICYHLNAV.EGNY.PRSMAG.....H.....L........DARREQ.....VDELCKKMETAGLLER.VE.SG.........TV.KQR.....RV.......KA..K.......QADEV.RQ.HHTYYRLSREGDHLLRF-l........................
G4RPG1_THETK/1-102               ................mel------SDLEKKILAHLYAF.GPDT.PSLIAH.....R.....LlgsagwrpVVPVED.....VERACAHLEELGLIER.YK.GSlkg..kvtsSI.KPW.....LK.......VK..Q.......RNPER.KG.SGIYYYLTKRGKQL----g........................
L0JY40_9EURY/94-186              .................ld--PLPTDPVAYLICYHLDAV.EGNY.PKSIAG.....H.....L........DAERNQ.....IRTLCKEMEESGLLER.VE.SG.........TV.KQR.....RV.......KA..K.......LADEV.RQ.HHTYYRLSRKGDHLLRF-l........................
G0EFH4_PYRF1/224-316             ..............lalit-----GHSKAHQLLQFLSEA.EHEH.IVAIAQ.....A.....L........SLQLEE.....AQRLIDKLIELGLVAE.TK.PK.........VL.KMK.....HR.......RA..K.......PKKET.RC.LHRYYRLTRLAELLIRY-s........................
Q4J7U2_SULAC/5-97                ..................l-KEVLKDKRLLEVLRHLKRA.NVDY.GKSIML.....N.....T........KIPLTE.....VLDVLDKLESLGLIER.VT.GA.........TL.KNT.....EA.......KF..K.......LSQEV.HK.HHTYYRLTRDGDHLLRRL.........................
A4XK03_CALS8/3-93                ..................v-RHDQDELLDLTILAYLKKL.GPEY.AKLLAI.....R.....L........GLSLEE.....SRKRLQSLEERGLIKR.VE.RR.........IV.KYY.....HR.......RR..K.......--SVK.HR.NHTYYELTREGELFLRE-a........................
N0BGN4_9EURY/5-111               ...............eeii----NLSELQKKVILHFLTF.GPDT.PKLMSR.....RllgvkT........HVDLQI.....LEKDCLKLCEKGLIKK.IA.GKkvpkrvptsSI.KPH.....IK.......IR..A.......KSKEI.RR.HGQYFELTHRGKQV----gkii.....................
B4U7S4_HYDS0/7-99                ..................g-HEYELSDLELKILKYHKTM.GPDY.SKLISH.....R.....F........HISLQE.....AFDIHKKLLDMGLLQK.VT.AP.........II.NYH.....SK.......DK..R.......LKSLK.HR.NHTYYDLSRTGKLLLREY.........................
F8I8R4_SULAT/46-80               ..............irlar--------------------.----.------.....-.....-........------.....----------------.--.--.........--.---.....HY.......HR..R.......LKAVK.HR.NHTYYQLTRDGEHFLRR-h........................
N0BK51_9EURY/102-194             .............lssitg------YDAALDIIEYLAKA.ECEH.AGWLAR.....V.....F........SMKVSD.....VQSLLTKLLDLGLLSE.CK.AK.........VL.KKK.....HR.......KG..K.......PKKET.RT.HHTYYRLSRLGEMMLRY-i........................
Q18IX1_HALWD/193-285             ..................q-NVLRHLPDGHTLIQRLARG.GPDY.PRMTAD.....E.....L........DMEFEY.....VRHLYRALRQVGLVTE.YE.GS.........TI.KAT.....ER.......KL..K.......PKDET.HR.KHTYYIVTDRGDEAFRRL.........................
L0AIU2_NATGS/94-186              .................ld--PLPADPVAYLLCYHLDAV.EGNY.PKSIAG.....H.....L........DAERSQ.....VRTLCTEMEQSGVLDR.IE.SG.........TV.KQR.....RV.......KA..K.......MADEV.RQ.HHTYYRLSRDGDHLLRF-l........................
G4RNA2_THETK/15-90               ..............leddl--------------------.---Y.GKSIAV.....N.....T........GIPLQR.....VLEILEKLEALGLVER.ARgGK.........TL.KRT.....EA.......RY..K.......LGHEV.RK.HHVYYRLTRKGRRLLRQ-e........................
N0BK51_9EURY/2-94                ................ldi---AKLSPLHIYILIHLRRA.NIDY.AKSISK.....I.....T........KIDQQE.....IEKALKELEELGLIDR.SH.GS.........AI.KRT.....AA.......RF..K.......LSHEV.HK.HHTYYCLTRLGEHTSR--ml.......................
F2KN96_ARCVS/6-98                .................fk--SVELKPLQVYILFHLRRA.NIDY.AKSIAR.....T.....L........KMEQQE.....IEKVLKELEDMRFIER.TH.GS.........AI.KRS.....EA.......RF..K.......LSHEV.RK.HHTYYGLTKDGEHTIRS-i........................
F4B6B1_ACIHW/9-101               ..................l-KEVLKDKRYLQVLQHLKKA.NVDY.GKSIML.....N.....T........KIPIQE.....VVDILDKLEALGLIER.VH.GA.........TL.KNT.....EA.......KF..K.......LSSEV.HK.HHTYYRLTREGDHLLRNL.........................
Q96YZ2_SULTO/1-106               ...............msel------SDLEKKILIHIYKY.GPDN.PWYMAR.....R.....LlgesgwapKYSEDE.....IEKACKKLEEEGLLQR.FQ.GA.........LK.RSV.....TSsvk.pwlKV..K.......AKELD.HKpKGIYYDLTKKGKKI----asel.....................
Q3IPF0_NATPD/10-83               .............iddqlh-------PADERILEYFAEE.PPDY.VPLAAN.....R.....L........GMHLGY.....VERRVETLVENGLLEP.VS.QE.........RI.YTI.....--.......--..-.......-----.--.------------------tdrgqrcveset.............
F8A7Z5_THEID/6-92                ...............wnil------DEKDWKILKDLYAH.APDC.AKFLSR.....R.....L........RFELGD.....TMERLRKLENLGFLER.IE.GR.........FL.KKK.....GL.......K-..-.......--RPK.HM.NHTYYELTRSCRLYLRK-d........................
E1QSW4_VULDI/2-92                ...............dglt-------DKDIAVLMHLKRA.NVDY.GKSIAI.....N.....T........GIPLEE.....VLQILDKLESMGLIER.VRgGK.........TL.KRS.....VA.......KF..K.......LSNEV.RK.HHVYYRLSRRGELLVRSL.........................
F6DSP3_DESRL/107-212             qlalqvyralldkgcleee----VENPLDLEILKFIEYA.GPEY.AWRLSI.....N.....V........NITVEK.....ARECLEKLLWKGLLER.VP.GN.........ML.GNY.....HR.......QK..D.......--WTK.HM.NHTYYRITREGRLYLRQL.........................
L0ABP7_CALLD/16-108              ................qri---YEISPLDLYILFHLKKA.NVDY.GRSIAS.....I.....L........GISIDI.....ITDELDKLEKMGLIER.HQ.GS.........AI.KRS.....EA.......KF..K.......LAEEV.RK.HHTYYKLTRETCLSIRKL.........................
D9PZR9_ACIS3/107-199             .................fe--YLTGHKNVLKLLLFLFEV.ENEH.AGTLAK.....V.....V........GDTPCN.....TVDLLDRLETLGLVTK.VK.EK.........VI.KAS.....HR.......KA..K.......PKPET.RT.HHVYYKVSELTKMLIRY-s........................
Q9HLB2_THEAC/8-100               ..................i-DELINDYDMLRVLKHFTIA.HVDY.AKNITR.....Y.....T........EIPQMR.....VREYLKRLKDLGLLDY.YT.NT.........SI.KRT.....EA.......KL..K.......KSAEV.HK.HHTYYQINKKAEAVLKEI.........................
T0LX01_9EURY/11-103              ................lle---VLKSPEMLRVLRHMHLA.KVDY.AKNTSR.....Y.....T........EIPLMR.....VTDYMKRLHSMRLLDI.YE.NT.........SI.KRT.....SA.......KL..K.......KSAEV.HK.HHTYYQINRNGDILLKE-v........................
D3TC09_ACIB4/1-90                ................mnl------SPLEIYIILHLKRA.NVEY.AKMIMK.....F.....T........HLSLDK.....IENAITSLENKGLVER.DS.GS.........AI.KRT.....RA.......RF..K.......KAKEV.HK.HHSYYHLSKEGSLLARRI.........................
Q6KZT6_PICTO/12-111              ...............isml------TDLEMDILKHLDKY.GPDS.PSIIWR.....R.....Ll.....ghMADKEQ.....VRFAFKHLKQEGYIRY.YG.NK.........VD.RNSltsslKK.......TL..K.......IKARKsNS.SRSYYELTEKGYEVLRK-n........................
Q97WF9_SULSO/113-205             ..................m-DIVKNDNLALNILRLADEL.NADH.ALTYAK.....L.....T........HKRLEE.....ITPKIEELVKMGLLEE.KN.SK.........II.KFA.....DR.......KA..K.......PKKET.RT.HHKYYGLSRIGELVVREM.........................
Q4J7U2_SULAC/107-199             ..................a-EIVKDDEVGLKLLYYAEEL.HSDH.ALTYSK.....L.....L........RKPLEE.....ITPKIEELERMGLMEE.KN.SK.........VI.KFR.....ER.......RA..K.......PKKET.RT.HHKYYGLTRLGELLVREL.........................
C9R7Q1_AMMDK/4-94                ...............tlnd----QEELLDLKILAYLKKL.GPEY.AKFLAR.....Q.....L........GLSLEE.....STERLRRLAARGLIKR.VE.GR.........IV.KYY.....HR.......QR..K.......--SVK.HR.NHTYYDITREGELLLRE-a........................
G0EFH4_PYRF1/2-106               ..............ehgld-------GLSLKVLLHLYEY.GPDT.PKLMCR.....R.....L........LGERTQldpalLERVLEAIAEKGLVKR.MQ.SK.........TV.PKN.....TA.......TSsiKpwikvrvKSSEV.RR.HGQYYELAREGEKLAKR-v........................
Q97WF9_SULSO/11-103              ................lri---ILRDIRYLTVLKHLKIA.NVDY.GKSIML.....N.....T........KIPLTE.....IVEILDDLEKLGLIER.VH.GA.........TL.KNT.....EA.......KF..K.......LSSEV.HK.HHTYYRLTREGDHLLRHL.........................
#=GC seq_cons                    ..................h......s.htlplLhaLccs.ssDY.u+slup.....t.....h........phslpc.....lpchlccLcphGLl-+.sp.up.........sl.Kpp.....ct.......+h..K.......hppEs.+p.HHoYYcLoRpG-hllRp..........................
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