GenomeNet

Database: Pfam
Entry: DUF3652
LinkDB: DUF3652
Original site: DUF3652 
#=GF ID   DUF3652
#=GF AC   PF12372.4
#=GF DE   Huntingtin protein region 
#=GF AU   Gavin OL
#=GF SE   Prosite
#=GF GA   20.90 20.90;
#=GF TC   22.00 20.90;
#=GF NC   20.30 20.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   7647777
#=GF RT   Cellular localization of the Huntington's disease protein and
#=GF RT   discrimination of the normal and mutated form.
#=GF RA   Trottier Y, Devys D, Imbert G, Saudou F, An I, Lutz Y, Weber C,
#=GF RA   Agid Y, Hirsch EC, Mandel JL;
#=GF RL   Nat Genet. 1995;10:104-110.
#=GF DR   INTERPRO; IPR024613;
#=GF CC   This domain family is found in eukaryotes, and is approximately
#=GF CC   40 amino acids in length. The family is found in association
#=GF CC   with Pfam:PF02985. This family is in the middle region of the
#=GF CC   Huntingtin protein associated with Huntington's disease. The
#=GF CC   protein is of unknown function, however it is known that a
#=GF CC   polyglutamine (CAG) repeat in the gene coding for it results in
#=GF CC   the development of Huntington's disease.
#=GF SQ   151
#=GS G3X9H5_MOUSE/1494-1534      AC G3X9H5.1
#=GS B5DYE6_DROPS/2808-2850      AC B5DYE6.1
#=GS R0LPW1_ANAPL/1464-1504      AC R0LPW1.1
#=GS L9KIK8_TUPCH/1746-1786      AC L9KIK8.1
#=GS L8IQA5_9CETA/1442-1482      AC L8IQA5.1
#=GS G1KE86_ANOCA/1480-1520      AC G1KE86.2
#=GS H2QP49_PANTR/1485-1525      AC H2QP49.1
#=GS A0PD97_CIOIN/1322-1362      AC A0PD97.1
#=GS B4GP12_DROPE/2525-2592      AC B4GP12.1
#=GS Q4S7T9_TETNG/1401-1441      AC Q4S7T9.1
#=GS E2AM71_CAMFO/1290-1330      AC E2AM71.1
#=GS H0V9L0_CAVPO/1518-1558      AC H0V9L0.1
#=GS T1F3E5_HELRO/1369-1409      AC T1F3E5.1
#=GS F6VQZ3_MACMU/1520-1560      AC F6VQZ3.1
#=GS V8NHE3_OPHHA/638-678        AC V8NHE3.1
#=GS W5KSK8_ASTMX/1558-1598      AC W5KSK8.1
#=GS A0A022T5I8_9HYME/1188-1255  AC A0A022T5I8.1
#=GS H9F754_MACMU/1438-1478      AC H9F754.1
#=GS U4UQK1_DENPD/175-215        AC U4UQK1.1
#=GS B4PQQ6_DROYA/2470-2525      AC B4PQQ6.1
#=GS Q59FF4_HUMAN/911-951        AC Q59FF4.1
#=GS B0R1X1_STRPU/192-232        AC B0R1X1.1
#=GS G1M886_AILME/1519-1559      AC G1M886.1
#=GS B0L1U1_BRAFL/1461-1501      AC B0L1U1.1
#=GS G3Q320_GASAC/1505-1545      AC G3Q320.1
#=GS G3TAJ5_LOXAF/1499-1539      AC G3TAJ5.1
#=GS H2ZNB5_CIOSA/1428-1468      AC H2ZNB5.1
#=GS G3W1T8_SARHA/1432-1472      AC G3W1T8.1
#=GS V4AN43_LOTGI/1383-1423      AC V4AN43.1
#=GS A0A026WC84_CERBI/1289-1329  AC A0A026WC84.1
#=GS A5A9V2_CIOIN/1323-1363      AC A5A9V2.1
#=GS H3AAE1_LATCH/1489-1529      AC H3AAE1.1
#=GS W5MWN7_LEPOC/1430-1470      AC W5MWN7.1
#=GS O42269_DANRE/1487-1527      AC O42269.3
#=GS B4HZ09_DROSE/2709-2751      AC B4HZ09.1
#=GS K1RMW1_CRAGI/1371-1411      AC K1RMW1.1
#=GS R7TWG0_CAPTE/1282-1322      AC R7TWG0.1
#=GS I3ME89_SPETR/1487-1527      AC I3ME89.1
#=GS A7RGU1_NEMVE/1541-1566      AC A7RGU1.1
#=GS G3GWA8_CRIGR/1300-1340      AC G3GWA8.1
#=GS H2SJ19_TAKRU/916-956        AC H2SJ19.1
#=GS G3RJY1_GORGO/1351-1391      AC G3RJY1.1
#=GS G3UGQ6_LOXAF/1446-1486      AC G3UGQ6.1
#=GS T1IW53_STRMM/1319-1359      AC T1IW53.1
#=GS B3LV94_DROAN/2694-2736      AC B3LV94.1
#=GS B0R1W9_STRPU/192-232        AC B0R1W9.1
#=GS I6L6Y1_TAKRU/1508-1548      AC I6L6Y1.1
#=GS F7C6C4_MONDO/1506-1546      AC F7C6C4.2
#=GS B4K7Q9_DROMO/2508-2571      AC B4K7Q9.1
#=GS Q9GM99_PIG/1514-1554        AC Q9GM99.1
#=GS M7BEE4_CHEMY/1313-1353      AC M7BEE4.1
#=GS G9K505_MUSPF/38-78          AC G9K505.1
#=GS W5PXJ0_SHEEP/1480-1520      AC W5PXJ0.1
#=GS G7MFT1_MACMU/1425-1465      AC G7MFT1.1
#=GS E1B8E7_BOVIN/1509-1549      AC E1B8E7.1
#=GS A4VAL4_BRAFL/1434-1474      AC A4VAL4.1
#=GS B5DYE6_DROPS/2527-2594      AC B5DYE6.1
#=GS G3Q318_GASAC/1511-1551      AC G3Q318.1
#=GS K7ECW3_ORNAN/60-100         AC K7ECW3.1
#=GS H9KNL1_APIME/1287-1327      AC H9KNL1.1
#=GS B0R1Y3_STRPU/1-27           AC B0R1Y3.1
#=GS K7J8T7_NASVI/1356-1396      AC K7J8T7.1
#=GS G3V9P7_RAT/1494-1534        AC G3V9P7.1
#=GS E2C517_HARSA/1283-1323      AC E2C517.1
#=GS E9GU71_DAPPU/1093-1133      AC E9GU71.1
#=GS V9IMF6_APICE/146-186        AC V9IMF6.1
#=GS F1P7Y7_CANFA/1503-1543      AC F1P7Y7.2
#=GS H2MI92_ORYLA/1506-1546      AC H2MI92.1
#=GS W5UM71_ICTPU/1474-1514      AC W5UM71.1
#=GS B0R1X3_STRPU/192-232        AC B0R1X3.1
#=GS F1S8N5_PIG/1513-1553        AC F1S8N5.2
#=GS H2SJ18_TAKRU/1518-1558      AC H2SJ18.1
#=GS G7NVR7_MACFA/1425-1465      AC G7NVR7.1
#=GS U3KPH8_RABIT/1442-1482      AC U3KPH8.1
#=GS B4N8Q2_DROWI/2203-2246      AC B4N8Q2.1
#=GS G1NJV8_MELGA/1450-1490      AC G1NJV8.2
#=GS B4PQQ6_DROYA/2740-2782      AC B4PQQ6.1
#=GS H0ZJI1_TAEGU/933-973        AC H0ZJI1.1
#=GS D3DVR8_HUMAN/968-1008       AC D3DVR8.1
#=GS B3LV94_DROAN/2411-2484      AC B3LV94.1
#=GS T1KK12_TETUR/1348-1388      AC T1KK12.1
#=GS F6Z217_XENTR/1506-1546      AC F6Z217.1
#=GS S7QAG9_MYOBR/514-539        AC S7QAG9.1
#=GS B4M193_DROVI/2490-2555      AC B4M193.1
#=GS T2MFD0_HYDVU/1001-1039      AC T2MFD0.1
#=GS B7U9A4_SHEEP/1502-1542      AC B7U9A4.1
#=GS H2ZNB7_CIOSA/1433-1473      AC H2ZNB7.1
#=GS H3C3K9_TETNG/916-956        AC H3C3K9.1
#=GS HD_HUMAN/1513-1553          AC P42858.2
#=GS U3K591_FICAL/1525-1565      AC U3K591.1
#=GS F6ZCK5_CALJA/1525-1565      AC F6ZCK5.1
#=GS Q9V3N4_DROME/2717-2759      AC Q9V3N4.1
#=GS Q9V3N4_DROME/2450-2505      AC Q9V3N4.1
#=GS B0R1X5_STRPU/1-27           AC B0R1X5.1
#=GS F6XPL5_CALJA/1503-1543      AC F6XPL5.1
#=GS S9Y008_9CETA/1349-1398      AC S9Y008.1
#=GS H3D3C4_TETNG/1480-1520      AC H3D3C4.1
#=GS U3IJW4_ANAPL/1483-1523      AC U3IJW4.1
#=GS L7MFQ9_9ACAR/1337-1376      AC L7MFQ9.1
#=GS B3P5R0_DROER/2439-2494      AC B3P5R0.1
#=GS HD_RAT/1484-1524            AC P51111.1
#=GS Q9U999_DROME/2451-2506      AC Q9U999.1
#=GS A4VAL3_STRPU/1516-1537      AC A4VAL3.1
#=GS L7LXD0_9ACAR/1315-1354      AC L7LXD0.1
#=GS H0WWN4_OTOGA/1477-1517      AC H0WWN4.1
#=GS B4GP12_DROPE/2793-2835      AC B4GP12.1
#=GS E1BZK0_CHICK/1451-1491      AC E1BZK0.2
#=GS J9KJG1_ACYPI/1187-1225      AC J9KJG1.2
#=GS D6X048_TRICA/1236-1276      AC D6X048.1
#=GS B3S350_TRIAD/963-1003       AC B3S350.1
#=GS B4QYS8_DROSI/3353-3395      AC B4QYS8.1
#=GS I3KRU4_ORENI/1495-1535      AC I3KRU4.1
#=GS F4W9A2_ACREC/1286-1326      AC F4W9A2.1
#=GS N6SZQ9_DENPD/175-215        AC N6SZQ9.1
#=GS B7XBM1_CALJA/1503-1543      AC B7XBM1.1
#=GS E9J746_SOLIN/1260-1300      AC E9J746.1
#=GS C3ZGJ9_BRAFL/1378-1418      AC C3ZGJ9.1
#=GS B4JXS7_DROGR/2411-2476      AC B4JXS7.1
#=GS HD_MOUSE/1493-1533          AC P42859.2
#=GS H9IYB8_BOMMO/522-547        AC H9IYB8.1
#=GS U6D7K6_NEOVI/1117-1157      AC U6D7K6.1
#=GS W4WVD3_ATTCE/1284-1324      AC W4WVD3.1
#=GS L7MDY1_9ACAR/1337-1376      AC L7MDY1.1
#=GS S4RKJ2_PETMA/810-850        AC S4RKJ2.1
#=GS A0A023EY16_TRIIF/1207-1246  AC A0A023EY16.1
#=GS E0W1H5_PEDHC/1220-1260      AC E0W1H5.1
#=GS B4N8Q2_DROWI/2701-2742      AC B4N8Q2.1
#=GS K7G9G4_PELSI/1468-1508      AC K7G9G4.1
#=GS B4QYS8_DROSI/3086-3141      AC B4QYS8.1
#=GS G1QHE5_NOMLE/1482-1527      AC G1QHE5.1
#=GS G1SY00_RABIT/1474-1514      AC G1SY00.1
#=GS M3W2I3_FELCA/1431-1471      AC M3W2I3.1
#=GS Q9U999_DROME/2718-2760      AC Q9U999.1
#=GS M3YH08_MUSPF/1391-1431      AC M3YH08.1
#=GS L5M3N0_MYODS/1577-1617      AC L5M3N0.1
#=GS D2H4H2_AILME/1431-1471      AC D2H4H2.1
#=GS G3RMC4_GORGO/1431-1471      AC G3RMC4.1
#=GS G1P179_MYOLU/1503-1543      AC G1P179.1
#=GS H2ZNB8_CIOSA/1354-1394      AC H2ZNB8.1
#=GS M3ZTD8_XIPMA/1509-1549      AC M3ZTD8.1
#=GS B3P5R0_DROER/2706-2748      AC B3P5R0.1
#=GS H2PCR6_PONAB/1503-1543      AC H2PCR6.1
#=GS W4Y8K8_STRPU/695-723        AC W4Y8K8.1
#=GS A0A023GCU2_9ACAR/1-36       AC A0A023GCU2.1
#=GS L5K4U1_PTEAL/1583-1623      AC L5K4U1.1
#=GS HD_TAKRU/1508-1548          AC P51112.1
#=GS B7ZDE9_DANRE/1487-1527      AC B7ZDE9.1
#=GS B0R1X9_STRPU/1-27           AC B0R1X9.1
#=GS F7BQH8_HORSE/1432-1472      AC F7BQH8.1
#=GS S5U636_CLABA/1474-1514      AC S5U636.1
#=GS G5BZF2_HETGA/1386-1426      AC G5BZF2.1
G3X9H5_MOUSE/1494-1534                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
B5DYE6_DROPS/2808-2850                 ..................................ALLQQPRVW-.........--RDLNASTDAALRCELLEVlc...........hsaRCMLQETIFYQ...............
R0LPW1_ANAPL/1464-1504                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
L9KIK8_TUPCH/1746-1786                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
L8IQA5_9CETA/1442-1482                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
G1KE86_ANOCA/1480-1520                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFIL-r..............
H2QP49_PANTR/1485-1525                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
A0PD97_CIOIN/1322-1362                 ..................................AVITMPKIIQ.........LCDGLMASGQGSASHVIPAM................QPIIHDIYVVR...............
B4GP12_DROPE/2525-2592                 .............llsrlhqlhdgeraqqlpmer----------.........LARRLTAQSGPAARAIIYERlldgdlaggedqdamrTLLLKDLECQQ...............
Q4S7T9_TETNG/1401-1441                 ..................................QIISIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
E2AM71_CAMFO/1290-1330                 ..................................AIIGIPKIIQ.........LCDGLMASGQPAITHCIPAL................APVIEDIFL--ir.............
H0V9L0_CAVPO/1518-1558                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
T1F3E5_HELRO/1369-1409                 .................................p-VITIPKIIQ.........LCDGIMASGLNPVKFCIPSL................HYVTKSLF---alk............
F6VQZ3_MACMU/1520-1560                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
V8NHE3_OPHHA/638-678                   ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFIL-r..............
W5KSK8_ASTMX/1558-1598                 ..................................QIISIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
A0A022T5I8_9HYME/1188-1255             kilqidnllpkiftffvhlsyekfhtkmvieire-------IIK.........LCDGLMASGQPPATHCIPGL................IPVVEDIFLT-r..............
H9F754_MACMU/1438-1478                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
U4UQK1_DENPD/175-215                   ..................................SIVDVPKIIQ.........LCDGLMASGQDPETHCIPSL................KPIVEDVFL--fr.............
B4PQQ6_DROYA/2470-2525                 ........................rslqlpierm----------.........-ARRLSAQSGQAARNVIYERlvegdlaggedqdalrTLLLKDLECRQ...............
Q59FF4_HUMAN/911-951                   ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
B0R1X1_STRPU/192-232                   .................................p-VIAMPKIIQ.........LCDGIMASGQQASTHIVPAL................KPLVHDLFIL-r..............
G1M886_AILME/1519-1559                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
B0L1U1_BRAFL/1461-1501                 ..................................SIIVMPRIIQ.........LCDGVMASGQKATNHAIPAL................QPIVHDLFVLR...............
G3Q320_GASAC/1505-1545                 ..................................QIISIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
G3TAJ5_LOXAF/1499-1539                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
H2ZNB5_CIOSA/1428-1468                 ..................................SVITMSKIIQ.........LCDGLMASEQGSASHVIPAM................QPITHDIFVVR...............
G3W1T8_SARHA/1432-1472                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
V4AN43_LOTGI/1383-1423                 ................................vi--IDMNGVIH.........RCDGIMASGLQPTKHAIPAL................RPIVYDLFLLR...............
A0A026WC84_CERBI/1289-1329             ..................................AIIGIPKIIQ.........LCDGLMASGQPAISHCIPAL................APVIEDIFL--ir.............
A5A9V2_CIOIN/1323-1363                 ..................................AVITMPKIIQ.........LCDGLMASGQGSASHVIPAM................QPIIHDIYVVR...............
H3AAE1_LATCH/1489-1529                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
W5MWN7_LEPOC/1430-1470                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
O42269_DANRE/1487-1527                 ..................................QIISIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
B4HZ09_DROSE/2709-2751                 ..................................ALLQQPRVW-.........--RELNASLDHSLRCELLDLld...........svaRCILQDTIFYR...............
K1RMW1_CRAGI/1371-1411                 ..................................SIIGMPKIIQ.........LCDGIMASGLQPVSHAIPAL................RPVVFDLFLLR...............
R7TWG0_CAPTE/1282-1322                 ..................................SIIGMPKVIQ.........LCDGIMASGLDPTLHALPAL................QCIVHDLFAL-r..............
I3ME89_SPETR/1487-1527                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
A7RGU1_NEMVE/1541-1566                 ..................................AIVGMAKVIQ.........LCDGIMASGQSAKTH-----................-----------g..............
G3GWA8_CRIGR/1300-1340                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
H2SJ19_TAKRU/916-956                   ..................................QIISIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
G3RJY1_GORGO/1351-1391                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
G3UGQ6_LOXAF/1446-1486                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
T1IW53_STRMM/1319-1359                 .................................l-IIGVPKIIQ.........LCDGIMASGQPPTTHAIPCL................IPIVEDLFLM-r..............
B3LV94_DROAN/2694-2736                 ..................................ALLLQPRVW-.........--RDLNARLDPGPRCDLLELld...........rvsGCILQDTIFYQ...............
B0R1W9_STRPU/192-232                   .................................p-VIAMPKIIQ.........LCDGIMASGQQASTHIVPAL................KPLVHDLFIL-r..............
I6L6Y1_TAKRU/1508-1548                 ..................................QIISIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
F7C6C4_MONDO/1506-1546                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
B4K7Q9_DROMO/2508-2571                 .......................lhqlhdgqral---------Qlp....merLSRRLTAQSSPAIRNSIYEQlvqgelaggddqdelrTMLLKDLECPQ...............
Q9GM99_PIG/1514-1554                   ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
M7BEE4_CHEMY/1313-1353                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
G9K505_MUSPF/38-78                     ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
W5PXJ0_SHEEP/1480-1520                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
G7MFT1_MACMU/1425-1465                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
E1B8E7_BOVIN/1509-1549                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
A4VAL4_BRAFL/1434-1474                 ..................................SIIVMPRIIQ.........LCDGVMASGQKATNHAIPAL................QPIVHDLFVLR...............
B5DYE6_DROPS/2527-2594                 .............llsrlhqlhdgeraqqlpmer----------.........LARRLTAQSGPAARAIIYERlldgdlaggedqdamrTLLLKDLECQQ...............
G3Q318_GASAC/1511-1551                 ..................................QIISIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
K7ECW3_ORNAN/60-100                    ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
H9KNL1_APIME/1287-1327                 ..................................AIIGIPKIIQ.........LCDGLMASGQPALTYCIPAL................APVVEDVFL--ir.............
B0R1Y3_STRPU/1-27                      ..................................----------.........----IMASGQQASTHIVPAL................KPLVHDLFILR...............
K7J8T7_NASVI/1356-1396                 .................................l-IIGVPKIIQ.........LCDGLMASGQPPLTHCIPAL................VPVVEEMFL--ar.............
G3V9P7_RAT/1494-1534                   ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
E2C517_HARSA/1283-1323                 ..................................AIIGIPKIIQ.........LCDGLMASGQPAISHCIPAL................APVIEDIFL--ir.............
E9GU71_DAPPU/1093-1133                 .................................t-IISVPRIMQ.........LAGGLMATGKDAELHVLPTL................QPMVEDLFLS-r..............
V9IMF6_APICE/146-186                   ..................................AIIGIPKIIQ.........LCDGLMASGQPALTYCIPAL................APVVEDVFL--ir.............
F1P7Y7_CANFA/1503-1543                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
H2MI92_ORYLA/1506-1546                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFIL-r..............
W5UM71_ICTPU/1474-1514                 ..................................QIISIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
B0R1X3_STRPU/192-232                   .................................p-VIAMPKIIQ.........LCDGIMASGQQASTHIVPAL................KPLVHDLFIL-r..............
F1S8N5_PIG/1513-1553                   ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
H2SJ18_TAKRU/1518-1558                 ..................................QIISIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
G7NVR7_MACFA/1425-1465                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
U3KPH8_RABIT/1442-1482                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
B4N8Q2_DROWI/2203-2246                 ..................................EINYFAKVLSekllgcldaLLHGLDPHSYPDAE------................PCLVGNAYCHL...............
G1NJV8_MELGA/1450-1490                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
B4PQQ6_DROYA/2740-2782                 ..................................ALLQEPRVW-.........--RELNASLDPLLRCELLELld...........svaRCILQDTIFYR...............
H0ZJI1_TAEGU/933-973                   ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
D3DVR8_HUMAN/968-1008                  ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
B3LV94_DROAN/2411-2484                 .......ilqalqvlsrlhqlheghrslqlpmer----------.........MARRLTAQSGNGIRNVIYEQliegelaggddqdalrTLLLKDLECRQ...............
T1KK12_TETUR/1348-1388                 .................................p-IITVPKIIQ.........MCDDLMASDQPPVFYALPAL................RQIVEDLMLYR...............
F6Z217_XENTR/1506-1546                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
S7QAG9_MYOBR/514-539                   ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTH-----................-----------g..............
B4M193_DROVI/2490-2555                 .....................srlhqlhdgqral---------Qlp....merLARRLAAQSSPATRSSIYERllqgelagdedqdelrTMLLKDLEYPQ...............
T2MFD0_HYDVU/1001-1039                 ..................................AIIGMPRIMR.........LCDSVMACGQPVHLYAIPAL................KPIVQDLF---g..............
B7U9A4_SHEEP/1502-1542                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
H2ZNB7_CIOSA/1433-1473                 ..................................SVITMSKIIQ.........LCDGLMASEQGSASHVIPAM................QPITHDIFVVR...............
H3C3K9_TETNG/916-956                   ..................................QIISIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
HD_HUMAN/1513-1553                     ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
U3K591_FICAL/1525-1565                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
F6ZCK5_CALJA/1525-1565                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
Q9V3N4_DROME/2717-2759                 .................................t-LLQQPRVW-.........--RELNASSDPSLRCELLDLld...........svaRCILQDTIFYR...............
Q9V3N4_DROME/2450-2505                 ........................rslqlpierm----------.........-ARRLSAQSGQPARNVIYERlvegdlaggedqdalrTLLLKDLECRQ...............
B0R1X5_STRPU/1-27                      ..................................----------.........----IMASGQQASTHIVPAL................KPLVHDLFILR...............
F6XPL5_CALJA/1503-1543                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
S9Y008_9CETA/1349-1398                 ..................................QIIGIPKIIQ.........LCDGVMASGRKGLR-----Rthrakcg..lgpipalRPIVHDLFVLR...............
H3D3C4_TETNG/1480-1520                 ..................................QIISIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
U3IJW4_ANAPL/1483-1523                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
L7MFQ9_9ACAR/1337-1376                 .................................p-VISMPEIIQ.........LCDRLMASGQPPDRYVIPAL................QAIVEDLFL--l..............
B3P5R0_DROER/2439-2494                 ........................rslqlpierm----------.........-ARRLSAQSGQPARNVIYERlvegdlaggedqdalrTLLLKDLECRQ...............
HD_RAT/1484-1524                       ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
Q9U999_DROME/2451-2506                 ........................rslqlpierm----------.........-ARRLSAQSGQPARNVIYERlvegdlaggedqdalrTLLLKDLECRQ...............
A4VAL3_STRPU/1516-1537                 .................................p-VIAMPKIIQ.........LCDGIMASGQQ---------................-----------l..............
L7LXD0_9ACAR/1315-1354                 .................................p-VISMPEIIQ.........LCDRLMASGQPPDRYVIPAL................QAIVEDLFL--l..............
H0WWN4_OTOGA/1477-1517                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
B4GP12_DROPE/2793-2835                 ..................................ALLQQPRVW-.........--RDLNASTDAALRCELLEVlc...........hsaRCMLQETIFYQ...............
E1BZK0_CHICK/1451-1491                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
J9KJG1_ACYPI/1187-1225                 ................................ni----IPEAIH.........LCDGLMASGYPPELYCIPAI................LPIVEYVY---vlk............
D6X048_TRICA/1236-1276                 ..................................SIITVPKIIH.........LCDGLMASEQSPLTHCIPAL................EPIVENIFLT-r..............
B3S350_TRIAD/963-1003                  .................................p-IVGIPRILQ.........LSDGIMASGQLAPAHVIPAF................RPVVFDLFNVR...............
B4QYS8_DROSI/3353-3395                 ..................................ALLQQPRVW-.........--RELNASLNPSLRCELLDLld...........svaRCILQDTIFYR...............
I3KRU4_ORENI/1495-1535                 ..................................QIISIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
F4W9A2_ACREC/1286-1326                 ..................................AIIGIPKIIQ.........LCDGLMASGQPAISHCIPAL................APVIEDIFL--ir.............
N6SZQ9_DENPD/175-215                   ..................................SIVDVPKIIQ.........LCDGLMASGQDPETHCIPSL................KPIVEDVFL--fr.............
B7XBM1_CALJA/1503-1543                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
E9J746_SOLIN/1260-1300                 .................................v-IIGIPKIIQ.........LCDGLMASGQPAISHCIPAL................APVIEDIFL--ir.............
C3ZGJ9_BRAFL/1378-1418                 ..................................SIIVMPRIIQ.........LCDGVMASGQKATNHAIPAL................QPIVHDLFVLR...............
B4JXS7_DROGR/2411-2476                 ..............lsrlhqlhdgqramqlpmer----------.........LARRLFAQSTPTTRSDIYDRlmhgelagdedqdelrTMLLKDLE---wp.............
HD_MOUSE/1493-1533                     ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
H9IYB8_BOMMO/522-547                   .................................k-IIEIPKLIQ.........LCDGLMASGAH---------................-----------aecia..........
U6D7K6_NEOVI/1117-1157                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
W4WVD3_ATTCE/1284-1324                 ..................................AIIGIPKIIQ.........LCDGLMASGQPAISHCIPAL................APVIEDIFL--ir.............
L7MDY1_9ACAR/1337-1376                 .................................p-VISMPEIIQ.........LCDRLMASGQPPDRYVIPAL................QAIVEDLFL--l..............
S4RKJ2_PETMA/810-850                   ..................................SIIGMPKIIQ.........LCDGLMASGRKAITHAIPAL................QPIVHDLFVVR...............
A0A023EY16_TRIIF/1207-1246             .................................p-VISVPEIIQ.........LCDGLMASGQNPVTHCIPAL................MPVVEHVF---li.............
E0W1H5_PEDHC/1220-1260                 .................................p-IISMPKILQ.........LCDDLMASDQPVQTHCLPAL................IPVVEDVFL--ir.............
B4N8Q2_DROWI/2701-2742                 ..................................ALLQHPRIW-.........--REVNASTT-GVRSELLEVlt...........mtgRCLLQDTIFYQ...............
K7G9G4_PELSI/1468-1508                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
B4QYS8_DROSI/3086-3141                 ........................rslqlpierm----------.........-ARRLSAQSGQPARNVIYERlvegdlaggedqdalrTLLLKDLECRQ...............
G1QHE5_NOMLE/1482-1527                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHVCPSL................R----------awwhdlgslqapppg
G1SY00_RABIT/1474-1514                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
M3W2I3_FELCA/1431-1471                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
Q9U999_DROME/2718-2760                 .................................t-LLQQPRVW-.........--RELNASSDPSLRCELLDLld...........svaRCILQDTIFYR...............
M3YH08_MUSPF/1391-1431                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
L5M3N0_MYODS/1577-1617                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
D2H4H2_AILME/1431-1471                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
G3RMC4_GORGO/1431-1471                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
G1P179_MYOLU/1503-1543                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
H2ZNB8_CIOSA/1354-1394                 ..................................SVITMSKIIQ.........LCDGLMASEQGSASHVIPAM................QPITHDIFVVR...............
M3ZTD8_XIPMA/1509-1549                 ..................................QIISIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVYDLFVLR...............
B3P5R0_DROER/2706-2748                 ..................................ALLQQPRVW-.........--RELNASLDPSLRCELLDLld...........svaRCILLDTIFYR...............
H2PCR6_PONAB/1503-1543                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
W4Y8K8_STRPU/695-723                   .................................p-VIAMPKIIQ.........LCDGIMASGQQASTHS----................-----------kys............
A0A023GCU2_9ACAR/1-36                  ..................................----MPEIIQ.........LCDRLMASGQPPDRYVIPAL................QAIVEDLFL--l..............
L5K4U1_PTEAL/1583-1623                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
HD_TAKRU/1508-1548                     ..................................QIISIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
B7ZDE9_DANRE/1487-1527                 ..................................QIISIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
B0R1X9_STRPU/1-27                      ..................................----------.........----IMASGQQASTHIVPAL................KPLVHDLFILR...............
F7BQH8_HORSE/1432-1472                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
S5U636_CLABA/1474-1514                 ..................................QIISIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
G5BZF2_HETGA/1386-1426                 ..................................QIIGIPKIIQ.........LCDGIMASGRKAVTHAIPAL................QPIVHDLFVLR...............
#=GC seq_cons                          ..................................pIIuIPKIIQ.........LCDGIMASGccAlTHuIPAL................QPIVHDLFlLR...............
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