GenomeNet

Database: Pfam
Entry: DUF3870
LinkDB: DUF3870
Original site: DUF3870 
#=GF ID   DUF3870
#=GF AC   PF12986.5
#=GF DE   Domain of unknown function (DUF3870)
#=GF AU   Ellrott K, Bakolitsa C
#=GF SE   JCSG structure PDB:3KOG
#=GF GA   22.00 22.00;
#=GF TC   22.10 44.00;
#=GF NC   21.10 20.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   15258571
#=GF RT   Clostridium perfringens epsilon-toxin shows structural 
#=GF RT   similarity to the pore-forming toxin aerolysin. 
#=GF RA   Cole AR, Gibert M, Popoff M, Moss DS, Titball RW, Basak AK.
#=GF RL   Nat Struct Mol Biol. 2004 Aug;11(8):797-8. 
#=GF RN   [2]
#=GF RM   15687495
#=GF RT   Structural analysis of the Laetiporus sulphureus hemolytic 
#=GF RT   pore-forming lectin in complex with sugars.  
#=GF RA   Mancheño JM, Tateno H, Goldstein IJ, Martínez-Ripoll M,
#=GF RA   Hermoso JA. 
#=GF RL   J Biol Chem. 2005 Apr 29;280(17):17251-9. 
#=GF DR   INTERPRO; IPR024617;
#=GF CC   A family based on the C-terminal domain of 3KOG which shows
#=GF CC   structural similarity to pore-forming proteins [1][2],
#=GF CC   suggesting it may have a lytic function. 
#=GF SQ   115
#=GS A0A0A8JDS2_BACSX/11-104   AC A0A0A8JDS2.1
#=GS Q8RIK6_FUSNN/14-107       AC Q8RIK6.1
#=GS H0UJN7_9BACT/9-102        AC H0UJN7.1
#=GS E4L0E3_9FIRM/6-97         AC E4L0E3.1
#=GS B7GJG1_ANOFW/10-103       AC B7GJG1.1
#=GS C0ZIB8_BREBN/8-100        AC C0ZIB8.1
#=GS R6Z565_9CLOT/9-102        AC R6Z565.1
#=GS N0AVC6_9BACI/5-98         AC N0AVC6.1
#=GS D5EEV1_AMICL/13-106       AC D5EEV1.1
#=GS A1HQA2_9FIRM/8-101        AC A1HQA2.1
#=GS A0A075RA44_BRELA/16-109   AC A0A075RA44.1
#=GS Q8CV94_OCEIH/5-98         AC Q8CV94.1
#=GS F9EL25_FUSNU/7-100        AC F9EL25.1
#=GS A0A0F2S9F9_9FIRM/11-104   AC A0A0F2S9F9.1
#=GS A0A0H4NV05_9BACI/9-100    AC A0A0H4NV05.1
#=GS D5DS28_BACMQ/8-101        AC D5DS28.1
#=GS A0A0F2Q847_9CLOT/9-99     AC A0A0F2Q847.1
#=GS A0A0F5I2P7_9BACI/8-101    AC A0A0F5I2P7.1
#=GS A0A0H4KBV1_9BACI/8-100    AC A0A0H4KBV1.1
#=GS D7GTW4_9FIRM/8-101        AC D7GTW4.1
#=GS E3HCU3_ILYPC/6-98         AC E3HCU3.1
#=GS A0A0M2SX61_9BACI/6-99     AC A0A0M2SX61.1
#=GS K6DM27_9BACI/8-101        AC K6DM27.1
#=GS C6JK22_FUSVA/8-101        AC C6JK22.2
#=GS A0A0F2S7E3_9FIRM/8-101    AC A0A0F2S7E3.1
#=GS A0A0M9UL73_9MICO/6-98     AC A0A0M9UL73.1
#=GS J1H1G6_9CLOT/133-225      AC J1H1G6.1
#=GS A1HNV3_9FIRM/10-103       AC A1HNV3.1
#=GS D9RZ14_THEOJ/10-102       AC D9RZ14.1
#=GS J7KZH5_NOCAA/18-111       AC J7KZH5.1
#=GS A0A0D5NRH8_9BACL/8-100    AC A0A0D5NRH8.1
#=GS A1HLW2_9FIRM/8-101        AC A1HLW2.1
#=GS F7NEZ4_9FIRM/8-101        AC F7NEZ4.1
#=GS D7GSW5_9FIRM/10-103       AC D7GSW5.1
#=GS D2RM09_ACIFV/11-104       AC D2RM09.1
#=GS A0A0H4KDY2_9BACI/7-100    AC A0A0H4KDY2.1
#=GS D3FW34_BACPE/8-100        AC D3FW34.1
#=GS D2RLJ2_ACIFV/7-100        AC D2RLJ2.1
#=GS F7NPD5_9FIRM/10-103       AC F7NPD5.1
#=GS G2THB0_BACCO/5-98         AC G2THB0.1
#=GS W1S9J2_9BACI/7-100        AC W1S9J2.1
#=GS A7GQ14_BACCN/8-99         AC A7GQ14.1
#=GS E3HA56_ILYPC/6-98         AC E3HA56.1
#=GS A0A0F2Q5G6_9CLOT/12-105   AC A0A0F2Q5G6.1
#=GS I8RMM0_9FIRM/8-101        AC I8RMM0.1
#=GS A6TKI3_ALKMQ/8-101        AC A6TKI3.1
#=GS A0A0C2Y861_BACBA/8-101    AC A0A0C2Y861.1
#=GS Q81CC2_BACCR/8-99         AC Q81CC2.1
#=GS E3HA05_ILYPC/6-98         AC E3HA05.1
#=GS A0A0F5HUE9_9BACI/8-100    AC A0A0F5HUE9.1
#=GS C5D5C9_GEOSW/5-98         AC C5D5C9.1
#=GS A0A0N1KGV0_9BACI/5-98     AC A0A0N1KGV0.1
#=GS K6DGN5_BACAZ/8-101        AC K6DGN5.1
#=GS F6CMA6_DESK7/6-99         AC F6CMA6.1
#=GS C2W4N4_BACCE/7-100        AC C2W4N4.1
#=GS G9PS13_9BACT/7-101        AC G9PS13.1
#=GS U5L832_9BACI/8-100        AC U5L832.1
#=GS Q5L2V1_GEOKA/5-98         AC Q5L2V1.1
#=GS A0A023CSL7_GEOSE/5-98     AC A0A023CSL7.1
#=GS A0A024P3C2_9BACI/5-98     AC A0A024P3C2.1
#=GS Q47R09_THEFY/16-107       AC Q47R09.1
#=GS D1B8D3_THEAS/7-100        AC D1B8D3.1
#=GS R7EGS4_9BACE/138-230      AC R7EGS4.1
#=GS A0A0A8JGQ5_BACSX/5-98     AC A0A0A8JGQ5.1
#=GS C2W8U3_BACCE/8-98         AC C2W8U3.1
#=GS A0A090J539_9BACI/8-100    AC A0A090J539.1
#=GS A0A075JL77_9BACI/5-98     AC A0A075JL77.1
#=GS E3PU98_CLOSD/8-101        AC E3PU98.1
#=GS D5WPS9_KYRT2/20-113       AC D5WPS9.1
#=GS C6JN72_FUSVA/5-98         AC C6JN72.2
#=GS G9PS12_9BACT/7-100        AC G9PS12.1
#=GS A0A024Q9H5_9BACI/8-99     AC A0A024Q9H5.1
#=GS Q9K8K2_BACHD/8-100        AC Q9K8K2.1
#=GS J1H8T0_9CLOT/9-102        AC J1H8T0.1
#=GS A8MEZ4_ALKOO/8-101        AC A8MEZ4.1
#=GS A0A024QII4_9BACI/5-98     AC A0A024QII4.1
#=GS E5WN72_9BACI/5-98         AC E5WN72.1
#=GS A0A090HZ88_9FIRM/272-364  AC A0A090HZ88.1
#=GS A0A0A1MC94_9BACI/8-99     AC A0A0A1MC94.1
#=GS R6Z0E5_9CLOT/7-100        AC R6Z0E5.1
#=GS C7MGS7_BRAFD/6-98         AC C7MGS7.1
#=GS U5RV72_9CLOT/7-99         AC U5RV72.1
#=GS E7GJC6_CLOSY/8-101        AC E7GJC6.1
#=GS J2QUE9_9BACL/11-104       AC J2QUE9.1
#=GS A0A0D1W806_ANEMI/8-101    AC A0A0D1W806.1
#=GS D7AZJ8_NOCDD/18-111       AC D7AZJ8.1
#=GS A0A0F2Q1G2_9CLOT/9-99     AC A0A0F2Q1G2.1
#=GS J1HAF7_9CLOT/9-102        AC J1HAF7.1
#=GS D1VS04_9FIRM/7-100        AC D1VS04.1
#=GS D5DYN4_BACMQ/8-99         AC D5DYN4.1
#=GS I0JQW6_HALH3/5-98         AC I0JQW6.1
#=GS R5H9V4_9FIRM/7-100        AC R5H9V4.1
#=GS G4KYX4_OSCVS/9-102        AC G4KYX4.1
#=GS C0Z7T0_BREBN/7-100        AC C0Z7T0.1
#=GS A0A0K8JF11_9FIRM/11-104   AC A0A0K8JF11.1
#=GS D6DEV3_CLOSC/106-199      AC D6DEV3.1
#=GS C5D8I9_GEOSW/8-100        AC C5D8I9.1
#=GS G4KSS1_OSCVS/8-101        AC G4KSS1.1
#=GS A1HUD6_9FIRM/10-103       AC A1HUD6.1
#=GS E5WSI8_9BACI/8-100        AC E5WSI8.1
#=GS U5RZE3_9CLOT/8-101        AC U5RZE3.1
#=GS R7B1U7_9CLOT/8-101        AC R7B1U7.1
#=GS G4Q457_ACIIR/10-103       AC G4Q457.1
#=GS A8MLS9_ALKOO/7-99         AC A8MLS9.1
#=GS H5UU61_9MICO/48-140       AC H5UU61.1
#=GS A0A0M8XJB5_9ACTN/18-111   AC A0A0M8XJB5.1
#=GS D2Z6Z5_9BACT/13-106       AC D2Z6Z5.1
#=GS A0A0M2VTC6_9BACL/8-99     AC A0A0M2VTC6.1
#=GS A0A0M2PJ04_9BACI/11-104   AC A0A0M2PJ04.1
#=GS A0A0C2TEQ0_BACBA/8-100    AC A0A0C2TEQ0.1
#=GS J1H1G6_9CLOT/9-101        AC J1H1G6.1
#=GS A0A0C2Y117_BACBA/7-100    AC A0A0C2Y117.1
#=GS A0A0D1VJT7_ANEMI/8-100    AC A0A0D1VJT7.1
#=GS R6RNU1_9CLOT/8-101        AC R6RNU1.1
#=GS E7GH00_CLOSY/8-101        AC E7GH00.1
A0A0A8JDS2_BACSX/11-104              ..l-VAGFAQLPKGTPVFELQKVIGCVLVVDTQTHIIEKATFTFIQAI.....TNEFLATIVEGRSIMDD.LEVITKDMEKKLLIPPQKATIQSFVSARNRY-l...
Q8RIK6_FUSNN/14-107                  ...YITGEARTTIDNAITKMFGTFYIAFEIILSTDEIIDVDCNATLRL.....TRDFVNRLFLNHNIIKD.EEMLKKEVTTRYFGSSSKAILTAYHDALQHYK....
H0UJN7_9BACT/9-102                   ...CVIGNARVKEGNPITHLYSSFFITFIVDSETGTILDAEASMTLDL.....TRRFVRDLLSGRSLADV.DESLIQLISCCYLGSSQKAMCVAYRDAVKKYR....
E4L0E3_9FIRM/6-97                    ...YLTGESRTSSDNAITKIYGVFYLAFEVD-EDGKIIDSDSNATLEL.....TRKFIKDIFAGKNIKD-.QEIITDEIQRRYNASSTKAIISAYKDALQRYK....
B7GJG1_ANOFW/10-103                  ...FIAGHARLPSGMAAKSVFDTLTITAEVDKKYGVIVDASCTLATEH.....GRDYVARLLKGHSLKDG.IDEPLAQLHEGYLGKANQALCAALKDLYKQY-c...
C0ZIB8_BREBN/8-100                   ...YIVGDAQSSSNNPITQQFSAFFIGLVVDTSNDKIVDAACSSTVQL.....TSDFARSIFIGHSIMA-.SEEIGEEIRFRYFGSSQKTLIAAFKDAQKKYK....
R6Z565_9CLOT/9-102                   ...LIVGQAKPSREDAIYSLHGEFYISLVLEKKSGTIINMDCNTILGV.....TRDFVADMIVGKSLKTD.MELLEKEIRSRYFAMTQKPLIACLKDACNRY-a...
N0AVC6_9BACI/5-98                    ...FIAGHAKLPSGMAARSVFETLTITAEIDKKYGVIVDASCTLATEH.....GKDFIRRILKGHSLLDG.IDLPLETLKNGYFGKANNALVAALKDLYKQY-e...
D5EEV1_AMICL/13-106                  ...LIVGNSQTTSFNPINQQFGAFFISFILLKDSEEIIDCGVSMTLKV.....TERFVQEVFLGRRLVQD.EEVIVSNVLTRYFGSSQKAIIAAYRDAIKKYK....
A1HQA2_9FIRM/8-101                   .lf--SGYARLPSGTVSGQIYRVMALVVLIDRQTDVIVDADCTLSTPM.....SAQFVARLLVGKSLRNG.PENLTQLIEKFYQGSAKKAIITAIRIIYDKY-l...
A0A075RA44_BRELA/16-109              .la--TGFAQLPKGTPLTDSQKMFACSLVMDSRTDLVVDASFTFLMGL.....NEEFIRGLVIGAYLPAE.WEKLQATIRKRALVPTQGTVLQALRSALDRY-l...
Q8CV94_OCEIH/5-98                    ...FIAGHAKLPSGMAAKSIYETLTITAEIDKKYGVIVTAGCTLATDH.....GKQFVQTILKGHSLQDG.IQFPLDHIKRHYLGKAGNALASALMDLFKQY-e...
F9EL25_FUSNU/7-100                   ...YVTGEARTTIDNAITKMFGTFYIAFEIILSTDEIINMDCNATLRL.....TRDFIKRIFLNHNIIKD.EEILKKEIATRYFGSSSKAILTAYHDALQHYK....
A0A0F2S9F9_9FIRM/11-104              ..l-VAGYAQVPKGSANYEQHKVIVVTLVVDLETSIIVDAGVNIDWDV.....INKFLRSKAIGLQLDNG.IEGYVQSIRSMASFSAIESFIQAFKICYERY-i...
A0A0H4NV05_9BACI/9-100               ...YIIGDAKAPLNNPITKHFNQYFIGLVVDRTSGKIVDVECSATIRL.....TVQFLKSIFVGKNIED-.-PVLIQEISQRYFGSSQKALIVAFQDAQKKYK....
D5DS28_BACMQ/8-101                   ...IVTGYAKAPQGTSMYEMYKHAGIVLEVDLTEHKIVNAEFTFITEL.....TQNFFRKLLIGYCLADG.IEPLIERIQNYYFAPSQQAIIVALQAAIQRY-w...
A0A0F2Q847_9CLOT/9-99                ..l-VGGSAKPPKEVT---VYQTMTVQLLIDTETNCIVETNFNLLSPL.....TQACLEELVNGYCLNDS.LEPLFKEIKEKICLSTTGALIRAIKNAVERYK....
A0A0F5I2P7_9BACI/8-101               ...FIAGHARLPQGMAAKSVFDTLTITAEVDVKYGVIIEASCTLATQH.....GREFIGNLLKGISLKDG.IEEPLQALQQFYKGKAANALAAALNDLHLHYQ....
A0A0H4KBV1_9BACI/8-100               ...YIIGDAKTSSNNPITQKYNAFFIALVVERSTGMIIDADCSATVPL.....TSAFVKSILIYKNIQD-.YEELCAEIQNRYFGSSQKALTVALKNALIKYN....
D7GTW4_9FIRM/8-101                   ...LVVGQAKPSKEDAIYNLHGEFYISLIVERDTGKILELDCNTILEV.....TKQFVASMFVGKSLRTD.VPLIEKEIRERYFALTQKPLIACMKDACNRY-l...
E3HCU3_ILYPC/6-98                    ...LVTGYSKIPGGISASDVYSVIGVSMEVDVETGEIIKADCSLVTKL.....AREFVKRILEGEKLTD-.ISALEHKFKNDYHGSTRKALITATKICCDRY-l...
A0A0M2SX61_9BACI/6-99                ...FVAGHSRLPAGMAAKNVYDTLTITVELERKYGVILEASCTLATEH.....GRDYIGRLLRGHSIQHG.VDHLVEEVKHHYYGKATNAIVAALADLHYQF-q...
K6DM27_9BACI/8-101                   ..f-LAGHSRLPQGMAAQSVYDSLTITVEVDKKYGVIIESSCTLATDH.....GKAYVQQILKGHSLQDG.IDDIIDALREGYRGKAVNALIAAVKDLYGQY-e...
C6JK22_FUSVA/8-101                   ...YILGVSKTNFDNAITKNYNMLFIGFLIDKNTNEIIDVEATMILEL.....SNRFIKSLFIGKNFIKD.QDIIINEFEKKYFGRSQKALITAYKDALKKYE....
A0A0F2S7E3_9FIRM/8-101               ...MIVGHSNLPQGMAAQSLFGTFAIVTEIDKKYGVIIRVSCTLVTQQ.....AQDFLATILVGSSLKDG.LEDVFAEIKSTYHGAAQNAIIAALKDLHRIY-l...
A0A0M9UL73_9MICO/6-98                ...YLTGEAKSPSNNPITTQWGLFFVGLVVDTETHVIQAADCTATLTL.....TVEFVRELVVGRSLLE-.EDALVESITDRYHGSSQKALAAAVRSAAAKYR....
J1H1G6_9CLOT/133-225                 ...CVVGFSKAVNKNPIVIGNQLLIGSFLIKTTTGEILDVQFNTICPK.....TSEFLSHLILGLSFYTE.LEEMIRRIQDQYWEDSNRAVITILRDANNK--v...
A1HNV3_9FIRM/10-103                  ...FVTGVAKPGKDDPIASIYQVFFVSMVVDARTDQIVDAACNTASPM.....TEGFIRSLLIGHNLAAG.VGEMTDAIRRRFFGLVQKALIVALKDAHNKY-m...
D9RZ14_THEOJ/10-102                  ...IVTGYAKLPGETTAQRLYTVVGVTLLVDTKTSNIMDADITLATNV.....ARDFFKRAVVGGNMEN-.FDSILKVFENQYWGTAKKSIITALKICLMKYK....
J7KZH5_NOCAA/18-111                  ...LISGYARLPDSVASHSQYQRLGVVLAVDSADGRIVAADTTLLTDL.....AKDFFRALVEGASVTED.IAEIVHRVQTRYAGQSGAALTTALRRCLETY-y...
A0A0D5NRH8_9BACL/8-100               ...YVIGDAQTSVNNPITQQYSAFFIGLVVDTTNHKIVDAGCASTIPL.....TSEFVRSIFTGQSILS-.FEQVAGEIRRRYHGSSQKALIVAFKDALKKYK....
A1HLW2_9FIRM/8-101                   ...YIVGNAKAGQNNPITLNYGQFFIAFVVHRETGEILECGASVMLDV.....TNRFIRQLFVGKSMETS.PFEVQKELEARYFGSSQKAILTAFKDAQRKF-n...
F7NEZ4_9FIRM/8-101                   .lf--SGYARLPSGTVSSEVYTVMALVVLVDIETDTIVEVDSTLSTRL.....AERFVSRLIVGQKLEPD.IGKLVGKINHAYQGSANKAIITALRIIADKYQ....
D7GSW5_9FIRM/10-103                  ...YIVGESRTNVDNAITKVYGSFFIAFEVIPSTGEIIQTDCSRTLEL.....TNDFIRKLFLHKHLETD.AKVIEEAIRRRYHGSSWKALIVAYRDALKHYQ....
D2RM09_ACIFV/11-104                  ...FVTGVAKVSREDVINTLYGTFTLSLVIDRKTGLILHCSANMIMAD.....TIAFLQDILIGKNLLTD.MDPMVRELRSRFLALSQKAVIAALKDAQNHY-l...
A0A0H4KDY2_9BACI/7-100               ...LITAYAKAPQNTSMYENYKYAGMVLEIHKESHIIINAEFTFLTTL.....AQDFFKRMVVGYDFSKD.INPLIEDIKTDFLAPSQQSVIVALKVAHQRYK....
D3FW34_BACPE/8-100                   ...YIVGEAKSPSNNPITEQYKVFFIGFVVDRLSGKIIDAEATSILSI.....TSSFIRHLFVGKNIRE-.TDQIVKAIEEKYYGSSQKAVIVAFRHASQKF-n...
D2RLJ2_ACIFV/7-100                   ...YITGEARTNMDNAITKIYGVFYMAFEVVEQTGEIVEVDCNATLEL.....TRNFIRKLFLNHSILSE.SQFLEQEVSQRYYGSSGKAILAAYRDARQHYR....
F7NPD5_9FIRM/10-103                  .lf--SGYAKLPTGITASEMYKVIGVVVLIDVEKEIITEADCTLATKL.....ANRHISSALIGCTMKDG.PDPLVRLVDQIYQGSAKKAIITALRIIYDKYR....
G2THB0_BACCO/5-98                    ...FIAGHAKLPSGMAAQNIYDTLTITAEIEMRYGVILDVSCTLATEH.....GRKFISHLLRGYSLNDG.IEEPLKQLQEFYLGKASNALISAFKDLYKQYR....
W1S9J2_9BACI/7-100                   ...FISAYAKAPQNTPMYENNKQIGVMLEIHKQNHIVVNVDATFITAL.....AKDYIKRLIVGTDFSKD.ISPLITDVENDCIIQSQQALVVALKVAHQKY-h...
A7GQ14_BACCN/8-99                    ...YIVGDAKAPQNNPITEKFKSYFVAFVLERDTGEIIDADCSATIAL.....TSQFVKHLFLHKNIND-.-SHLADEIKGRYFGSSQKALLVALKDAQKKYN....
E3HA56_ILYPC/6-98                    ...LVTGYSKIPGGIAGSDVYSVIGLSLLVDATTGKILEADTNLVISL.....ARRHINDILVGEKITD-.LQALEYRFKSEYHGSARKALIVAMKICYDRY-l...
A0A0F2Q5G6_9CLOT/12-105              ..f-LAGHAALPQGMAAKGPYEHLAVVVEIDSKYGVIINAECTLITDL.....AINFLHDCLVGCCMEDG.VDAIISEIINTYHGAAKNAIIASLKDLNRAY-i...
I8RMM0_9FIRM/8-101                   ...CIVGDAKSPQNDAVTHQYGRFSICFVVDKDSGNIITCSSTFAISL.....TNDFITTIFNNKSLTTD.SEIIRTEVENRYFGASQKAIIVAFKDAQKKYN....
A6TKI3_ALKMQ/8-101                   ...YIVGHGRTSSDNAITHHYKIFFISFVVKIETTEIIDLECSATVDI.....TKKFVHSLFIGKKLGEF.DEEIEEEIKRRYFGSSQRAIIVAYKDGVKKF-n...
A0A0C2Y861_BACBA/8-101               ...FIAGHARLPQGMAAKSVFDTLTITAEVDTKYGVIIEASCTLATEH.....GREFIGQLLKGVSLKDG.IDEPLKQLQQYYKGKAANALAAALNDLHLHYQ....
Q81CC2_BACCR/8-99                    ...YIVGDAKAPQNNPITEKFKSYFVAFILVKDTGEIVDADCSATIAL.....TSQFVKYLFLHKNIND-.-PALVMEVKNRYFGSSQKALLVALKDAQKKYN....
E3HA05_ILYPC/6-98                    ...LVTGYSKVPAKTSAADIYSVMGICMEIDVESGYILEADCTLVTEL.....SKNYVIGLLKGENIND-.IAALEEKFRKGYQGSAKKALVTGMKICHDRY-l...
A0A0F5HUE9_9BACI/8-100               ...YVIGDSKTASNNPIMQQFNTYFIGLVIDRDSHEIMEAECSSTISL.....TSRFVQSIFVGRSIMD-.MEDIIEEIENRYFGASQKALTVAFKNAYIKYN....
C5D5C9_GEOSW/5-98                    ...FIAGHARLPAGMAAKSVYDTLTITAEIDKKYGVIVDASCTLATEH.....GRDYVARLLKGHSLRDG.IDSILEQLNEGYLGKANSALCAALKDLYKQY-c...
A0A0N1KGV0_9BACI/5-98                ...FIAGHARLPAGMAAKSLYDTLTITAEIDKKYGVIVEASCTLATEH.....GRDYVARLLRGHSLRDG.IDGLLAELDEGYLGKAHSALCAALKDLYKQY-c...
K6DGN5_BACAZ/8-101                   ...FIAGHSRLPQGMAAKNIYDNLTVTAEIDCKYGVILEASCTLATNH.....GRDFIGKLLRGYSIKDG.IDEPIKAVQMYYHGKATNAIIAALKDLHFQF-m...
F6CMA6_DESK7/6-99                    ...FVAGHASLPQGMAAKGIYGTLAIVAEIDRKYGVIVQASCTLVTPL.....AQEYIRSILVGHSLLDG.IEGPIQEIKEYYHGAAQNALIAALKDLYRTY-l...
C2W4N4_BACCE/7-100                   ..f-MAGHSRLPKGMAVRSVYETLTITIEADHKYHVIIEASCTLATEH.....GRDFIAQMLRGHSLQDG.IEDIIQEISHHYQGKAQNAIISAVKDLYRQY-t...
G9PS13_9BACT/7-101                   lfg---GYSQFPQGTPGHEIFKYFGIGFEVDPESWEIVDVSSTFLTEL.....SSRFLRSVFVGKNIREGgVGVGIREFEARYFCRGKRTIVAAIIEAEKSY-l...
U5L832_9BACI/8-100                   ...YIIGDSKTSSNNPIMQKYNGFFIALVIDRDTHKIEDAECSSTIGL.....TSLFVKSLFAGKSMLE-.EEGILSEIEARYFGSSQKALMVAFKNASIKYK....
Q5L2V1_GEOKA/5-98                    ...FIAGHARLPAGMAAKSLYDTLTITAEIDKKYGVIVEASCTLATEH.....GRDYVARLLRGHSLRDG.IDGLLAELDEGYLGKAHSALCAALKDLYKQY-c...
A0A023CSL7_GEOSE/5-98                ...FIAGHARLPAGMAAKSIYDTLTITAEIDKKYGVIVDASCTLATEH.....GRDYVARLLKGHSLRDG.IDSILEQLNEGYLGKANSALCAALKDLYKQY-c...
A0A024P3C2_9BACI/5-98                ...FVAGHSKLPTGIAANHISESLTLTLEIDKKYGVILDASCTLATEH.....GRGFIKSLLKGYSLKDG.IDEPVARLKEGYLGKAGSALEAALKDSYKQYQ....
Q47R09_THEFY/16-107                  ...LISGYARLPDTVAGRHQYERLGVVLAVERSTGRIVAADSTLITEL.....AREFFRVLVEGLSIYDD.LAEIVHRVQTRYAGQSGAALATALRRCLE---s...
D1B8D3_THEAS/7-100                   .fl--AAYARLPQDIAAYGLYKSVGVYAEVEVDTGVIIEADVSFYSQV.....SINMIRAILKGKNIVLD.REVILKAFESRYWGGGRKAVITAVKRLFERY-d...
R7EGS4_9BACE/138-230                 ...--VTDPKVKTWDN-YELYWFDIPSFPYVVKEGAKVGAKKINTTDLieraaIESFFNTL---ENTYEE.TTVTTPENKYKVYANSRTTASITYTVVTTEYK....
A0A0A8JGQ5_BACSX/5-98                ...FIAGHARLPSGMAAQNMYETLTITAEIDKKYGVIVTASCTLATLH.....GRDFFQQILKGHSLQDG.IEKPIADIKNHYLGKASNALVSALKDLHKQY-e...
C2W8U3_BACCE/8-98                    ...YIVGDAKAPQNNPITEKFKSYFVALVVEKDTGKIVDADCSATISL.....TSQFVKHIFLHRNIND-.-PQLVGEIKNRYFGSSQKALLVALKDVTKK--i...
A0A090J539_9BACI/8-100               ...FIIGDAKAAANNPITQKYNAFYIGLVVDRDSGEIIDADCSATLDL.....TKQFIKSLLIGKSILD-.IEIITSDFEKRYFGSSQKAFIVAFRNAHLKY-l...
A0A075JL77_9BACI/5-98                ...FIAGHARLPSGMAAKSIYETLTITAEIDQKYGVIVAANCTLATEH.....GKSFIQQLLRGYSLQDG.IEKPVDEIKARYLGKAGNALASALKDLYKQYK....
E3PU98_CLOSD/8-101                   ...YIIGHARTQADNAITEHFKGFFIGVVVDYITDEIVDISCSSTIPT.....TEKFIQSLFINKKLDKY.YGEIDRQIEQRYFGTSQKALSTAYKDAVKRY-a...
D5WPS9_KYRT2/20-113                  .fa--AGFAELPKGTTAYEAYRIVSFVMVVDSRTDIVVDAGFSFALPL.....TGEFVRSLVIGENVLDG.LDAIQKKVRTRFLAPAQGALLQAVRSAFDRYR....
C6JN72_FUSVA/5-98                    ...YIVGNAKTNLDNPITKNYNKFFLAFIVSEKDDIILEIEVSSILKI.....TNSFVREIFVGKNFIKD.QDKIIAEVERTYLGSSQKSIIVAYKDAIKKY-i...
G9PS12_9BACT/7-100                   ...CIIGNARTQQKNPITARFSHFFIVFIVEAGTGKIVDLDVTVMLPA.....TSNFIKELFLGRSLAEV.DKELLELIRGSYLASSQKAIQMAYMEAVKKYR....
A0A024Q9H5_9BACI/8-99                ...YVIGDAKAPQNNPITKKYSQFFLALVIDATTDDIVDCECSSTVQL.....TNQFVKSLFIGRKIDD-.-SLIEEAIRKRYHGSSQKALVVAYQDAKYKYN....
Q9K8K2_BACHD/8-100                   ...YIVGEAKSPSNNPITQQYKIFFIGFVVDRKTGKIVDADVSSILPL.....TSTFIRHLLIGQNILE-.PETIIQIIEDRYHGSSQKAIIVALRNASQKFQ....
J1H8T0_9CLOT/9-102                   ...FVTGVAQIGKTDAINAMYGTFSLSLIIDTHSDTIISLSCNMVMAE.....TIEFVRQLLIGKNIVTD.MDEMIETIQKRFLALSQKALIVALRDAQNRYQ....
A8MEZ4_ALKOO/8-101                   ...YVIGHGKTSNDNAITERFKIFFIGFIIDTETDEIVDIGCSTTIPT.....TEEFIAGIFVGRKFDKF.YEDIEQEVIRRYFGSSQKAIVVAYKDALKKYQ....
A0A024QII4_9BACI/5-98                ...FIAGHARLPSGMAAQSIYETLTITAEIDKKYGVIVAAGCTLATDH.....GKSFVQQLLRGHSLQDG.IDKPVEILKSHYLGKAGNALASALKDLYKQY-v...
E5WN72_9BACI/5-98                    ...FIAGHAKLPQGMAARNLYDSITITVELDFKYGVIVDSSCTLATEH.....GREYIRQLLRGYCLREG.VEELINRVQRHYRGKAGQAIQAALKDVYLQY-e...
A0A090HZ88_9FIRM/272-364             ...YITGESKTNMNNAITKMYGSFFLAFEVEIDSGIIVRADSNTTLDL.....TKSFISRLFIGKNMKD-.DEFITEEITNRYYGSSAKAIIAAYHDALKHYE....
A0A0A1MC94_9BACI/8-99                ...YIIGDAKASQNNPITKKYSQFFVALVVDFQTDEIVDCECSSTIQL.....TNHFVKSLFIGEAMGN-.-SLIEESIRKRYHGSSQKALLVAYRDAEYKY-t...
R6Z0E5_9CLOT/7-100                   ...YVTGESRTSVENAITKTYGAFYVAFEINGRTGEIVEADCSGTLEL.....TRSFVRRMFVGKRILED.DQKIEEEIRRRYFGSSVKALLVAYRDARKRF-g...
C7MGS7_BRAFD/6-98                    ...YLTGEAKSPTNNPITSQWGLFFIGLVVDTETHVILDADCTAMLTL.....TVEFVRELLVGRPLLE-.EDALVESITERYHGSSQRALAAAVRSAAAKYR....
U5RV72_9CLOT/7-99                    ...FVSGYAKLPGGITATEVYTEIAMTAVLDRITGKIYEIECTLVTNT.....AREYIKKLLIGRNIKD-.IDDMVKDISDNYFGIAKKAIIASLTNCYERY-i...
E7GJC6_CLOSY/8-101                   ...LIVGQAKPSREDAIYTLHGEFYISLVVEKESGKILDIECNTILAV.....TRNFVADLFIGKSIKTD.LEELEKTIKERYFALTQKPLIACMKDAHNRY-m...
J2QUE9_9BACL/11-104                  .lt--AGFAQIPKGTTLYEVSTMVGCVLIIDADDGVICDASFTFVMDK.....TSEFLVSLLVGKSVAGG.MQEIAQTIQERFLAPGQGAVLQAIRAAVDRY-h...
A0A0D1W806_ANEMI/8-101               ...FIAGHARLPQGMAARSIFDTLTITVEADAKYHVILEASCTLATDH.....GRDFIGQLLRGCSLQDG.IEDLSRRIMDFYQGKAQNALVAALRDLHNQY-l...
D7AZJ8_NOCDD/18-111                  ..l-VSGYARLPDSVASHSQYQRLGVVLAVDTADGRVVAADTTLLTEL.....ARDFFRALVEGESVTED.VAELVRRVQTRYAGQSGAALTTALRRCLETY-v...
A0A0F2Q1G2_9CLOT/9-99                ..l-VGGTAQPPKEIT---VYNIMTVQLLIDLETGCIVESHFNLISPL.....TQACLKELINGYCVNNS.LEPLFNEIKTKICLSTTGSLIQAIKNAVDRYK....
J1HAF7_9CLOT/9-102                   ...YLVGHAKVASDNPISISYGIFFLPFVVDLHTHQIVDVSCNAILDI.....SRDFVRSLLVGCDLLDG.LDDAIHRVRSRYFGSSQKALVAALRDAN----grlr
D1VS04_9FIRM/7-100                   ...YFTGEARTTMDNAITKIYGTFYMAFEVDASNGKIIRTDCNGTMKL.....TKDFINRIFEGKIFDDD.EDKIIEEISERYYASSTRAIVVAYRDALQKYK....
D5DYN4_BACMQ/8-99                    ...YIIGDAKAPQSNPITKKFNQYFLGLVVDKTNGKIVDVECSATIEL.....TVRFVQSIFIGRHISD-.-PTLTDEINSRYFGSSQKALVVAFHDAQKKYQ....
I0JQW6_HALH3/5-98                    ...FVAGHSKLPTGMAANHISESLTLTLEVDKKYGVIVDASCTLATDH.....GREFIKSLLKGYSLKEG.TDEPVARLKEGYLGKAGNALEAALKDSYKQYQ....
R5H9V4_9FIRM/7-100                   ..f-LSGYAKLPDNTTAQKLYNHLVLVVTAESSTGTILDADCTMATEL.....GRRFIRELLVGYALTRG.PDPLVERLNQSYYGHLRKALQTCIKGICFQY-g...
G4KYX4_OSCVS/9-102                   ...LVVGQAKPSRTDAIYQTHGEFYISLVMERETGRILDMTCNTILDV.....TAEFVRDMLVGKRLPED.LPTLETAIRTRYFALTQKPLIACLKDAANRYR....
C0Z7T0_BREBN/7-100                   .lt--AGFAQIPKGTTLYEVSTMVGCVLIIDVDAEVICDASFTFVMDK.....TSEFLVSLLVGKTVADG.MQEITKAIQERFLAPGQGAVLQAIRAAIERY-h...
A0A0K8JF11_9FIRM/11-104              .lf--SGYAKLPIGITANEIYKVVGIVVLVNVNTGEIVEADCTLATKL.....ARRHIADALTGYNLNQG.MEDLVHLIDRIYQGGAKKSLITTIRIIYDKYR....
D6DEV3_CLOSC/106-199                 ...LVVGQAKPSREDAIYSLHGEFYISLVLEKESGKILNVECNTILHV.....TSDFVAEMFIGKSLRTD.LELLEGEIRSRYFAMTQKPLIACMKDAYNRY-m...
C5D8I9_GEOSW/8-100                   ...YIIGDAKAPSNNPITQQYKAFFIGLVVNKESGIIVDADCSATIEL.....TKSFVKSLLVGRSILD-.IDTVKKEIETRYFGSSQKALIVAFKNASLKYQ....
G4KSS1_OSCVS/8-101                   ...YIIGESRTNSDNAITKIYGSFYMALEIEAESGKILDFGCTHSLDL.....TEQFLRRIFVGRSLLEQ.SAQIEDEVVRRYHGSSAKAVLAAMKDAEKRYR....
A1HUD6_9FIRM/10-103                  .lf--SGYAKLPTGITASEMYKVIGVIVLIDVLTGEIVEADCTLATQL.....ARKHVSAALVGHSLKNG.PDQALRTIDLVYQGSAKRAIITAIRIIYDKYR....
E5WSI8_9BACI/8-100                   ...YIIGDSKTSLNNPIMQKYNGFFIGLVIDRETDEIVDAECSSTINL.....TSLFIKSIFVGKSILE-.ADKVTEEIESRYFGSSQKALMVAFKNAHIKY-t...
U5RZE3_9CLOT/8-101                   ...YVVGNAKTNEDNAITIRFNSFYIGFVVDLSTDKVIDLNSSSTLRT.....TDEFIRSLLIGRNLRIF.DDKLKEEVIKRYHGSSQKAIIVAYRDGVKKYN....
R7B1U7_9CLOT/8-101                   ...LVVGQAKPSKEDAIYSLHGEFYVSFVVERATGKILDLECNTILSV.....TRNFVVSMLLGKSLKTD.LDEMQQSIRERYFALTQKPLIACLKDAHNRY-m...
G4Q457_ACIIR/10-103                  ...FVTGVARVSKEDAINAMYGTFTLSLVVDVKTGTIINCSANMIMSD.....TIDFLRQIIEGKNLVTD.TDLITDLLKKRFLALSQKAVVAALKDAQNRF-l...
A8MLS9_ALKOO/7-99                    ...FISGYAKLPMGTTAEELYKVIAVGILVDKNTGEILDADCTLVTSV.....AKNLVNKLLVGKNILR-.FEEIEKAINERYFGTVKKSLISSIKKCHDK--lk..
H5UU61_9MICO/48-140                  ...YLTGEAKSPTNNPITARWGLFFVGLVVDTETHVVVEADCTATLSL.....TREFVAELLRGRSLLD-.EDALVEVITARYHGSSQRALAAAVRNAAHRYR....
A0A0M8XJB5_9ACTN/18-111              ...LISGYARLPDSVASHSQYQRLGVVLAVDSSDGRIVAADTTLLTDL.....AKDFFRALVEGASVTED.IAEIVQRVQTRYAGQSGAALTTALRRCLETY-y...
D2Z6Z5_9BACT/13-106                  ...CVIGNARSASDNPITHTYSHFFITFIADPDTGEILDMEASFTLSL.....TNRFLRDLFLGRSLAAV.DEGLLEAVRRRYLGSSQKAIAVAYKDAVKKF-v...
A0A0M2VTC6_9BACL/8-99                ...FIIGDAKAPQNNPITKKYNQYFLAMVVAQTDGKIIDVECSATVDI.....TKRFVQSLFIGRNMDD-.-PSIVEDISQRYFGSSQKALIVAFNDALKKYQ....
A0A0M2PJ04_9BACI/11-104              ...LVTGYAKAPQGSAMFEIYKTSGIVLEIDYETNVIVNAEFTFVTNL.....ARDFLSRLIVGYDLSKG.LESLIQRIEAHYYTQSTNSVIVAVKAAYKRY-m...
A0A0C2TEQ0_BACBA/8-100               ...YVIGDSKTASNNPIMQQFNSYFIGLVIDRKNHKIIEAECSSTISL.....TSQFVQSIFNGRSMME-.FEDIVADIENRYFGASQKALIVAFKNACIKYN....
J1H1G6_9CLOT/9-101                   ...YVTGVARPTPENPIAVNYDRLLVILIFEPETGEIVDAEVNMICST.....TRNFIKSLLVGYCLYSD.IPQIMENIQSRYWGLSRRALIVCMKDALAK--v...
A0A0C2Y117_BACBA/7-100               ...LITAYAKAPQNTSMYENYKYAGIVLEIHKESHIILNAEFTFLTNL.....AQDYFKRMIIGYDFSKD.IKPLIEEITSDFIAPSQQAVIVALKVAHQRYK....
A0A0D1VJT7_ANEMI/8-100               ...YIIGDAQSSINNPITQQYSAFFIGLVIDCRSDKIIDAGCSSTIPL.....TSDFVRSIFVGRTIWE-.TEELAGEIRRRYHGSSQKALIVAFKDAQKKYR....
R6RNU1_9CLOT/8-101                   ...LVVGQAKPSREDAIYNLHGEFYISLVVERDTGRILDVDCNTILSV.....TKNFVASMFVGKNLRTD.TEVLEREIKERYFALTQKPLIACMKDAYNRY-m...
E7GH00_CLOSY/8-101                   ...YIIGESRTNLDNAITKVYGTFYIAFEIIPETEEIIEVDCSRTLEL.....TKDFIRRLFIGKKFVTD.AEQIEAEVKRRYYGSSTKAIIVAYRDALKRFK....
#=GC seq_cons                        ...alsGpA+hPpssshpphYsshhlshhlDpcoGtIl-AsCohshpl.....opcFlpplllG+slt-s.h-tlhcclcp+YhGsop+AllsAh+DAhp+Y.....
//
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