GenomeNet

Database: Pfam
Entry: DUF4380
LinkDB: DUF4380
Original site: DUF4380 
#=GF ID   DUF4380
#=GF AC   PF14315.4
#=GF DE   Domain of unknown function (DUF4380)
#=GF AU   Eberhardt R
#=GF SE   Jackhmmer:Q7UYS3
#=GF GA   29.40 29.40;
#=GF TC   30.10 31.10;
#=GF NC   29.10 27.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR025488;
#=GF CC   This family of proteins is found in bacteria, archaea and
#=GF CC   eukaryotes.  Proteins in this family are typically between 288
#=GF CC   and 372 amino acids in length. There are two completely
#=GF CC   conserved residues (G and E) that may be functionally important.
#=GF SQ   23
#=GS U5Q609_9BACT/41-272      AC U5Q609.1
#=GS Q21JR3_SACD2/57-345      AC Q21JR3.1
#=GS Q5H6C8_XANOR/75-369      AC Q5H6C8.1
#=GS E6WUB2_PSEUU/31-324      AC E6WUB2.1
#=GS C5BPK4_TERTT/57-354      AC C5BPK4.1
#=GS Q11P91_CYTH3/75-295      AC Q11P91.1
#=GS K9RCR4_9CYAN/49-317      AC K9RCR4.1
#=GS B3PDI4_CELJU/33-239      AC B3PDI4.1
#=GS A0A0F2QMX5_9RHOB/1-292   AC A0A0F2QMX5.1
#=GS Q2RGX0_MOOTA/16-319      AC Q2RGX0.1
#=GS B3PL34_CELJU/26-320      AC B3PL34.1
#=GS Q8P3C5_XANCP/43-337      AC Q8P3C5.1
#=GS A0A0M2PXQ1_PROHO/78-330  AC A0A0M2PXQ1.1
#=GS C5BMK8_TERTT/54-250      AC C5BMK8.1
#=GS S0EU37_CHTCT/38-196      AC S0EU37.1
#=GS A0QZF1_MYCS2/19-307      AC A0QZF1.1
#=GS I3IBT1_9GAMM/40-290      AC I3IBT1.1
#=GS Q21L48_SACD2/136-242     AC Q21L48.1
#=GS K1YQV5_9BACT/22-224      AC K1YQV5.1
#=GS B8CXN3_HALOH/13-294      AC B8CXN3.1
#=GS D9WIT1_9ACTN/25-325      AC D9WIT1.1
#=GS A0A0E3ULR8_9GAMM/32-327  AC A0A0E3ULR8.1
#=GS A6GIW0_9DELT/1-249       AC A6GIW0.1
U5Q609_9BACT/41-272                 ..............................................apqgwdgdgy-----------------------------------------.--..-....-------.------....--...-------.....---------------------W..P.GPPDHILdG..GVYE...CNTENNLVT..LKSPVDKRTG..LQIQRQFTV-NPDVA...TIDISATFTNKIDK.DIRWSV..W....PVCQV......A.......VDEQAV---....-EQSQ-....I.VCPAKKDSK.GNAQYKVLHGLannpqYMCDEAGNlvVAYKYIVGKVGTDSADGWIACVNrsSGKVLVMNFDVADGA.E-YPD.GT.SLQV...WtqgegatysrgrvnIH....KSDRK.........V..NPP.YMEMEILSPLVKLSPGESYD.--------fqyti.....................................
Q21JR3_SACD2/57-345                 ........................................................IQQLQLSNQISTFTITPQIGGRGLHFGLVGADNVLKVNERL.LS..L....PAPKVSS.SSDNIG....YL...GHINWIG.....PQAEWWLHQTENLERRQQKAVW..P.PDAHTVL.A..SATL...NAISGNAVT..MTLPASPVTG..LRLDKSYGL--HDDG...SLQLDVTATNTRQA.SVAWDI..W....FNTRL......N.......ANSVLYVPV....AGAQNV....R.IDTFGETPF.-KQSVVVDEGM.....LTIDL---..TVADRLKGKAFVQPSKGWMAAFT..ADQLFVIEFTLQPQA.VIHPA.QG.QLEF...Y..............LD....YSAKS.........V..DAG.LLEMELHSPYTHLEPGESFS.AQEVWRVY..........................................
Q5H6C8_XANOR/75-369                 .......................................................v-ECIQLRSKAVELSATPAFGGRVLSFNLRGQPNVLKVGAAV.EQ..Q....PAPEVSA.ASGDIA....YF...GHDVWVG.....PQSQWWLHQQLNHERQAAAAVW..P.PDPYLSL.A..HTHL...ARRSHDALE..FEGVPSPLTG..VQLRKQIQLSAGRAD...TVEIQASARNIRTE.AIAWDL..W....FNTRV......A.......ATTRVFVPV....AAAGDI....R.VQPPSEAGT.TAPRFKRARGV.....FALRADAG..QDGLIQRGKLLLQPSAGWMAGFA..GGQVLLIRFAHQPLA.AIHPE.QG.QVEL...Y..............LD....TPRRH.........P..EQG.LLEMEVHAPYRQLAPGAQMQ.AQEQWTLL..........................................
E6WUB2_PSEUU/31-324                 .......................................................q-ARVRLESPQLQLEVSPRLGGRMLHISLPGAPNLLRVGEAV.DS..Q....PDPKVSA.NADNIP....YM...GHEVWTG.....PQSQWWTGQTLNQARRKAAAVW..P.PDPWLSH.G..KTRV...LEQGDTRLV..LEGAASPVSG..VQLVQGFDL---SHE...RAELAVEMRNIRKE.PVSRDI..W....FNSRV......P.......PDTRVYVPV...aADGSGV....R.VRSDTEDGY.DALVTSSDDGL.....FSLELLPP.gEGLQGRRGKVFIQPEAGWIAGFN..AGQAFVIHFEKQPVE.RIHPE.QG.QVEL...Y..............LD....WRPDP.........A..YPS.LMELEVHAPFVTLEPGQSTT.AREWWIV-r.........................................
C5BPK4_TERTT/57-354                 ........................................................VQQITLGNGVVSLQVTPDIGGRVLGVSLTDRQNLLRVGTEE.LA..R....GVPEVKA.DDRAYS....YF...GHIVWNG.....PQSDWWKFQTVNPQRRAQKAQW..P.PDPFNVL.A..RNEI...VAHTAESLV..LQSPPSALTG..LAMRKVFRLPAKHKN...SVELMVDAQNAQPEgSVAWDL..W....FNTRV......S.......AASKVLVPV....ASEQQV....R.VQQPFYPKQqDPIAYTVAEGT.....LVLNQLAA.tAPSRKRVGKLFITPDAPWMASFS..QGQVLLIQYPSVPSA.DIHPE.HS.LVEL...Y..............MD....FDGDD.........F..AAG.LIEMEVHSAYRELAPGTTLT.SRERWTVL..........................................
Q11P91_CYTH3/75-295                 .............................sgtnilsgktvnagnwgtsmwpspqra-----------------------------------------.--..-....-------.------....--...-------.....-------------------WGW..P.PSQQLDN.L..AYT-...VLQDSGAVV..LKSQKDPKQG..FVFTKAYSI---DTK...DTSLIITYTILNDT.TVAQKVagW....EISRV......A.......PGGLTFYPS....GDEAK-....-.------RGQ.LAPLTKDTLGV.....TWFEYKAA..-TIPSGVPKLLADGKEGWLAQAK..GALLLVKTFEDVATG.KYAPE.EG.EIEL...Y..............A-....----N.........P..DHS.YIEIEQQGTYVQLKAGETLT.Y-------vvryklv...................................
K9RCR4_9CYAN/49-317                 ....................................................dsyi-----LSNSQVEAVIVPAI-GRIMQFRFPDGENTFWEDSQL.YG..K....-VPNKKS.EEWN-N....FG...GDKTWPA.....PQSEWK---------KMTKISW..PpPDTFDSV.P..VK--...VEVQKNEIT..LISEIDPFYG..IRFYRQITL-EPNEP...IMKVTTTFEKVKGD.SQQVSV..W....TITQL......N.......EPVSVFAAI....PQPSIF....P.QGYNKQSDD.LPANLKIDNGI.....LSLTRDRD..--KPHKIG-----SDASTLLWVG..EKTAVRMDSPR-IDK.VIYPDnNS.NSEI...Y..............TN....YDPKA.........-..---.YVELEFLSPLKTLQVGEKMD.LTVT----ytli......................................
B3PDI4_CELJU/33-239                 ...............................................sgtvlwssp-----------------------------------------.--..-....-------.------....--...-------.....----------------QAEWNW..P.PIDVLDS.L..P-YK...VETQNNQLV..LTSEVDPKTG..YQFSKTYLP--AGKN...AIAVTYRIYNRGKV.EKRVGA..L....EVTRV......P.......PAGDVLFPL....GDTAPV....-.-SGI----F.YPLPVSLEQGL.....CWFQYDGK..-KIRDDHHKIMLDGKEGWVAYRN..KGYLLIKEFEDLPPN.VIAEG.ER.EIEV...F..............--....---AH.........V..EHT.FIEIKQQSAVETLAPGEFLT.WTVVWH--al........................................
A0A0F2QMX5_9RHOB/1-292              ......................................................me--YITLERSGVAVTITPAFGGRVTGFGLAGRDSMVLFDATLaAE..Q....PAPPVEI.SAAALP....YQ...GQSLWVG.....PQSEWWTHQTAAPE--MQGESW..P.PDPYLTT.V..KTRV...IR-TPYSVT..LQGPASPYTG..LKVHQTYEL--LESG...CLKLTAVAENTRQT.PVSWDL..W....TNVRV......P.......GDAWVFAPV....SDAAAI....R.PGPTNDPAF.QPPQLGYADGL.....AFADPSMD.gVTAPAREGKVFLDTDEGWMAGVR..DGQAFRVSFALSPLA.AIHPA.QG.QVEF...Y..............FN....QPSDK.........S..SAG.VIEMETHAPYRTLQPGETMQ.AVQFWSI-q.........................................
Q2RGX0_MOOTA/16-319                 ......................................................ga---VEFGNDLIRVVMVPNLGGRIMAYDLGD-YSFLYVNKEL.EG..K...lFTPEENY.GDGSIAawknYG...GDKTWPA.....PQG--W-----DTE---EEWHG..P.PDPVLDS.GvyTGRW...LECSPEKVSyeVESPPDPRTG..IKLFRKVTI-RQDSS...KLWLELRMKNISSR.PVAWSI..WnvtqLDTRLrngkgyD.......PNCRLYIPLnpvsRFAKGY....R.VIFGEEDNP.-QWGQREGNDL.....LVIPY---..---LFYVGKIGVDSPVGWMAFVNdtEGYTWCLRYPYYPEEkDAYPD.GGcSVEC...W..............TVgrgvVTGKD.........YsqETGyHIEAEVLGPVRKLKPGEE--.--------qflel.....................................
B3PL34_CELJU/26-320                 ........................................................IQRLPLNTSAISVEVTPDIGGRILAIALPGKENFLRQGEAV.IS..E....PEPYVAP.DADNVG....YL...AQETWLG.....PQSQWWTQQLVNPARAQAKAVW..P.PDPYLIL.A..KNQV...VQADKRRVV..MRTPASPVSG..VVVEKHYALVEGKPD...QLHLMARATNIRDT.TVAWDI..W....FNTRV......P.......PSSQVYVPV....ASQEDV....R.VEHMENEQR.GSLGYRLVDGF.....FTFVSKAH..PDKPGVRGKAFIQPSAGWMAAFR..EGQVFIIHFPLQPTA.VIHPE.QG.QVEL...Y..............LD....SIPEY.........P..SQG.LLEMEVHAPYRKLQPGAHME.AEQTWRLL..........................................
Q8P3C5_XANCP/43-337                 ........................................................IERLTLGNEVIEVTATPSFGGRILAFQLRGQPSVLKLGAAV.EQ..Q....RAPQVSG.TAGDIA....YL...GHDVWVG.....PQSHWWLHQQVNPQRKAAGAVW..P.PDPYLSL.A..TTRA...TIHDATQLV..MDGVPSPVTG..VQLRKRVALSPSRPD...TIDVQATARNIRTE.PLSWDL..W....FNTRV......A.......ADTRVFVPV....ADAADL....R.LQPPSDPGT.VAPRYQLEGGL.....FVLSADTR..ADTLIQRGKLLLQPSAGWMAGFA..GTQVLVIRFAHQPKA.RIHPE.QG.QVEL...Y..............LD....APPQH.........P..EHG.LLEMEVHAPYRTLAPGADMQ.AQEQWTLL..........................................
A0A0M2PXQ1_PROHO/78-330             .................................................gryrlsl--------DTVTVEVDAQQGGRIIAFALDG-ENLLRDNS--.--..-....VDPQ---.---N--....-Y...GSTFWVS.....PQAIW---------------DW..P.PVPEIDR.A..PYQV...LQ-SDRSLR..LVSQPSPSLG..IQVSKSLALGRFRADgspTLRLTYRITNTHTH.PLRYAP..W....EVSRV......S.......PTGVTFYPT....GSAL--....-.---YGSGSF.GTPLTETSAGV.....TWWNHDSA..PLSQ--DQKLFAEGFGGWLAHLD..GDKLFLKTFPDITAA.DQAPR.ES.EIEV...Y..............AN....-----.........G..NHT.YVEMEAQGAYTRLAPGESLE.WTVGWSV-h.........................................
C5BMK8_TERTT/54-250                 ..................................................spqslw-----------------------------------------.--..-....-------.------....--...-------.....--------------------QW..P.PPVELDE.A..PYEL...VEHSPERIC..LRSPVESQLG..IQVTKVFSP---IAN...GFNVAYVIANVLGD.IVSMAP..W....EISRV......S.......GGLSFY---....------....R.AATPPEAHS.-TCDAVFAEGC.....YWYEY--K..VDGLTGIPKLFANNSAGWLAYVE..GNQLLVKTFPTITPE.EVAPG.EG.EVEI...Y..............GH....ADV--.........-..NNP.YVEIEQQGPFRAIMPGMRLI.WAVDWRI-f.........................................
S0EU37_CHTCT/38-196                 .....................................................nay----QLSNGDVELVVVPQIG-RIMRYGPVGGPNMLWNNPTM.LG..K....TAS-LEA.AAKEWP....NF..gGDKLWPA.....PQSVW---------------NW..P.PDPYLDS.A..PQTV...RVLPNHHLL..VIGQASPQSG..IRFEREIAL-APKGD...EVTLVNIMINTSSK.PVKWAI..W....EIFQA......N.......DPLRVYLPT....------....-.---------.-----------.....--------..-----------------------..---------------.-----.--.----...-..............--....-----.........-..---.--------------------.--------nisghf....................................
A0QZF1_MYCS2/19-307                 .....................................................wir-------TGSLTLGVVPALGGRLLSLRLGERELLWRNPALL.GE..D....LQPVGGHiPAPVSG....RL...GDWCNYG.....GDKTWPAPQGWSSPQ---QWAG..P.PDPVLDS.G..HYAVdvcRWEATTELA..VTSPPDPRTG..LQITRTFTV--NTDS...EFVIHLSATNVTDH.EVTWAL..W....NVTQL......P.......GGGTVEVDV....EHRFTE....P.IEILAGTGV.-PTWRRSGPDT.....ITID----..--PQDVVGKLGFPYATGRLRYLH..QNVTLAWDFPVDEDA.PYPDE.GS.RAEL...W..............ME....H----.........-..---.--------------------.--------pqpaplasldgldppdrivecevlsashtlapgssmtfpvkl
I3IBT1_9GAMM/40-290                 ...........................................srllikqgkvrle-----------------------------------------.--..-....IMPKVGG.RISSLK....YA...GHELLVPivdldKVTDW---GTVLWSSPQTDWGW..P.PIDVLDN.K..PYRL...T-TEEDRVV..LMSEIDPRTG..YQFTKTYRP--SGVD...RITIDYRIANHSTE.RKNVAP..L....EVTRL......P.......SSGSLFFPS....GDSE--....-.---ISSGLF.YPLDVQMIDEL.....TWFDYD-K..KKIRTDHHKMMQDGKEGWMAYVD..QGYLLVKEFNDSPAG.TTAKG.ES.EIEI...F..............--....---AH.........V..EHI.FIEMKQQASLVTLEPGQHLD.WTVTWHV-k.........................................
Q21L48_SACD2/136-242                ..................................lpnsnlpmqregnvflyehnpk-----------------------------------------.--..-....-------.------....--...-------.....----------------------..-.-------.-..----...---------..----------..---------------...--------------.------..-....-----......-.......---------....------....-.---------.-----------.....--------..--LLTEGVKCFANNSGGWIANIF..AGQIFIKGFPKLDEA.DVSPS.EG.EVEV...Y..............A-....--FDS.........E..SNP.YVEVEVQGPYTTIASGAQTSwAVDWWL--ip........................................
K1YQV5_9BACT/22-224                 .........................................inprtyapdnspvqa-----------------------------------------.--..-....-------.------....--...-------.....----------------------..-.-------.-..----...-EMKADTLH..LTQDTEAMTG..IQKELEITL-SDREN...RVQVLHRMTNRGVW.TINLSA..W....GLTVM......N.......TEGLAIIPQp..qGDREALlpnwG.MTLWPYTDM.TDPRVRWGRKF.....ITLQQD--..-PGISPRFKIGLRASSGWVGYLR..KNQLFVKQFIHQPEA.DYPDW.GC.SLEV...F..............--....-----.........T..NEA.ILEIESLSPLTTLEPGQELE.HVEQWYL-f.........................................
B8CXN3_HALOH/13-294                 .....................................................qgy----ELKNKVISLILLPEVGGKIVSFSYRGQDLFFNLPENS.TS..KidlsRIGDVKS.YRKKFD....YVptgGYKTWLA.....PQSKW---------------DW..P.PYLDLEL.G..SYNMsvfQEKDKIQVE..LTSPVCRESG..MRLMRVITLKAGSP-...EVTIKQGMENCSTT.DRTFGL..W....DVTQI......H.......GEGRVIFPI....LSDDSL....GyIVTPEKNNY.-TERYNFDGKS.....FI-SVHCP..GQEIF---KLGTGYSKGWILTLV..EKEDWLLGYLK----.-IFPV.FS.GARFghgY..............AM....EVFDT.........N..KYN.YFEVEVHGPLNKIRPQDKYF.FTEEWRVL..........................................
D9WIT1_9ACTN/25-325                 .....................................................yel---VRLDAGAVQLTAVPALGGRLLSLTLHGREFLYRNARLL.DGglR....PRPGVRP.VPQDGP....MS...AWLNWGG.....DK-TWPAPQGWDG-----PGQWsgP.PDSVLDS.G..PYELrltVQGGTAQAV..MTSGVEPRTG..LRIERRVTLTA-GRT...AFTLENTLTNESDR.PRRWAV..W....NVTQL......AgtapgsyPAGGVYVGT....ADSG--....R.PETVGLIAG.TGRPHVHRTGI.....GTLHV---..-PHQDVVGKVGFPDAAGWLAHVA..PQGTLTQRFEVSPTA.RYPDA.DS.RVEV...W..............LE....HPLHApldhlgglrP..RDR.IVECEALGPLQELAPGQST-.--------rltme.....................................
A0A0E3ULR8_9GAMM/32-327             .......................................................s--QVRLESPKLRMEVSPRLGGRVLHFSLPDSPNLLRIGAAV.EA..Q....PEPKVQA.AGGNIP....YL...GHEVWVG.....PQADWWRDQAVNPARRKAGAQW..P.PDPWLAH.A..PARV...VAHGDDRLV..LEGAASPVSG..VRLTQTFSIAADRPH...TAELAVEMRNIRKA.PVSRDI..W....FNTRV......H.......PETRVYVPV...aADGSRV....R.VRSDTGDGF.DGLVSSSADGL.....FSLELLPP.sDGLRGRRGKVFIQPRAGWIAGFN..AGQAFLIHFERQPLE.RIHPD.QG.QVEL...Y..............LD....WRPGQ.........D..DTG.VLELEVHAPYVTLAPGDSTT.AHEWWVV-r.........................................
A6GIW0_9DELT/1-249                  mtrpslrsesltleldpacggriaslrhgarellvspsvhpdnwgatlwtspqsdw-----------------------------------------.--..-....-------.------....--...-------.....--------------------GW..P.PVAAVDS.E..PYEL...VEHGPSAIT..LRSPVATMGPrrLQITKRAAV--VAGG...SIDLRYAITNLGDA.PFAMAC..W....EVSRV......F.......PGGLSFFPT....GRAA--....-.--LTELPPH.GPLEPDTEAGF.....SWFDHAA-..-FAPGQNRKLHADGEGGLLAHCV..DDLLLLKCFTDTPPA.DQAPG.EG.EVEL...F..............AF....E----.........-..DGS.YVELEVQGAYASIEPGAEL-.--------afgvr.....................................
#=GC seq_cons                       .......................................................h.......t..lph.hsPthGGRhhthth.s...hhh.st....t.........P.ht.....s.s....hh...Gp.hW.u.....sps.W..............hsW..P.PsshLs..u..shpl...sppssspls..LposssPhoG..lplp+phsl...pss...plplphphpNhpsp.slshsl..W.....sTRl......s.......sssplahPs....usstt.....h..t..ttssh..s.thphspGh.....hhhph.......h.t.hsKlhhpsssGWlAths..tsplhlhpFsp.Ptu.shtPt.pu.plEl...Y..............hp.......tt.........s..pts.hlEhEspuPhppLtPGpphp.h...W.............................................
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