#=GF ID   DUF4458
#=GF AC   PF14660.10
#=GF DE   Domain of unknown function (DUF4458)
#=GF AU   Godzik A;0000-0002-2425-852X
#=GF SE   Jackhammer:Q8ABA0 
#=GF GA   22.40 22.40;
#=GF TC   25.90 24.70;
#=GF NC   21.70 19.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0287
#=GF DR   INTERPRO; IPR027899;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   this domain is found in tandem repeats on the N-terminus of
#=GF CC   secreted LRR proteins from human associated Bacteroidetes domain
#=GF CC   boundaries are based on the JCSG solved 3D structure of JCSG
#=GF CC   target SP16667A (BT_0210)
#=GF SQ   46
#=GS A0A108T6M3_BACSE/44-145   AC A0A108T6M3.1
#=GS A0A374CK64_9BACT/39-143   AC A0A374CK64.1
#=GS A0A255SXE6_9BACT/164-285  AC A0A255SXE6.1
#=GS R5VC81_9BACE/167-286      AC R5VC81.1
#=GS A0A1Y3VII0_9BACT/164-292  AC A0A1Y3VII0.1
#=GS E5C3L2_9BACE/151-262      AC E5C3L2.1
#=GS A0A108T7M6_BACSE/41-154   AC A0A108T7M6.1
#=GS A0A108T6M3_BACSE/159-273  AC A0A108T6M3.1
#=GS A0A3L7Z266_9BACE/160-283  AC A0A3L7Z266.1
#=GS A0A1Y3VII0_9BACT/38-148   AC A0A1Y3VII0.1
#=GS R6DGD6_9BACE/39-143       AC R6DGD6.1
#=GS R6DIK5_9BACE/158-278      AC R6DIK5.1
#=GS R6NMJ2_9BACE/165-285      AC R6NMJ2.1
#=GS A0A3L7Z266_9BACE/41-147   AC A0A3L7Z266.1
#=GS A0A4Y1X0R2_9BACT/168-292  AC A0A4Y1X0R2.1
#=GS A0A173WWD7_9BACE/39-147   AC A0A173WWD7.1
#=GS Q8ABA0_BACTN/39-146       AC Q8ABA0.1
#=GS A0A255SXE6_9BACT/39-151   AC A0A255SXE6.1
#=GS A0A174JDN5_9BACE/36-140   AC A0A174JDN5.1
#=GS A0A173XHS4_9BACE/39-147   AC A0A173XHS4.1
#=GS A0A4Y1X2H6_9BACT/174-306  AC A0A4Y1X2H6.1
#=GS Q8ABA0_BACTN/159-279      AC Q8ABA0.1
#=GS R6C1A8_9BACT/39-143       AC R6C1A8.1
#=GS R6NMJ2_9BACE/40-152       AC R6NMJ2.1
#=GS A0A4Y1X0R2_9BACT/36-155   AC A0A4Y1X0R2.1
#=GS A0A108T7M6_BACSE/167-297  AC A0A108T7M6.1
#=GS A0A174JDN5_9BACE/155-270  AC A0A174JDN5.1
#=GS R6XX68_9BACT/39-143       AC R6XX68.1
#=GS R6XX68_9BACT/156-277      AC R6XX68.1
#=GS A0A2T5C643_9BACT/162-275  AC A0A2T5C643.1
#=GS R5UX62_9BACT/36-141       AC R5UX62.1
#=GS A0A173WWD7_9BACE/160-283  AC A0A173WWD7.1
#=GS R5UX62_9BACT/154-274      AC R5UX62.1
#=GS R6C1A8_9BACT/156-277      AC R6C1A8.1
#=GS R6DGD6_9BACE/156-277      AC R6DGD6.1
#=GS A0A173XHS4_9BACE/160-283  AC A0A173XHS4.1
#=GS A0A2T5C643_9BACT/39-147   AC A0A2T5C643.1
#=GS R6DIK5_9BACE/39-145       AC R6DIK5.1
#=GS A0A374CK64_9BACT/156-277  AC A0A374CK64.1
#=GS R5VC81_9BACE/41-154       AC R5VC81.1
#=GS A0A174PVX0_9BACE/42-135   AC A0A174PVX0.1
#=GS R6VIB4_9BACT/28-143       AC R6VIB4.1
#=GS E5C3L2_9BACE/25-138       AC E5C3L2.1
#=GS R6VIB4_9BACT/156-281      AC R6VIB4.1
#=GS I9RNR0_9BACE/36-147       AC I9RNR0.1
#=GS A0A4Y1X2H6_9BACT/44-161   AC A0A4Y1X2H6.1
A0A108T6M3_BACSE/44-145              .................GYLQLRLFAEG-...............--TTRA....---LNDMA..DAKKIELEL--.DCDGLTVVQTLGLSSVPE...........---...........-AEGAGLITEKIE.LLTGDYQLMSYTIYGAVK.....------..---------------pgkdtpeelaygypgdlnfqiaqgh
A0A374CK64_9BACT/39-143              .................GYVQFKLSKKVS...............TRATRAa..aLDKLEKLD..DAKKIKVVM--.EHNGTTVSQTLVLNSYNS...........---...........ENAEYGLRSEKLQ.LASGTYTVIGFYLYDAVD.....EELLAS..S--AGETFTVVGGGL.........................
A0A255SXE6_9BACT/164-285             .................GSVKFRLTKHW-...............-DNTRS....GSGEYLFS..NIRLVDVSVTN.LFTRETITFPELKVTYEEdse.....lhqNPDnpd.....dkyMDIATARCDSAVS.LPAGTYQVTSYTTYGKSGa..vkKTFETQ..P-VKGEAFVVADNQL.........................
R5VC81_9BACE/167-286                 .................GMVKFKLVKDG-...............--LSRA....-AGEYLFS..SIALVDVTVTN.AFTQMSTTFNKLKVTYEEdye....esvsE-Ddpn.....dkyKNIATAKCDSAVW.LEAGTYRVTAYTTYSKSGv..reSELETQ..T-VNGEVFTVTDNV-l........................
A0A1Y3VII0_9BACT/164-292             .................GKVRFNLIKDISql...........tgEWKSRAs..sRTREYTFD..EIAYFDVTVHKvNSDEQEITFTYLESTFSIhf.......deE-Dres....ddfgYQTSSITCDSLLS.LPAATYEITGFVTYDSNK.....LVLESHtgEEFPDSNFTVADNE-t........................
E5C3L2_9BACE/151-262                 .................GMVKFTVTKNF-...............LPSTRA...aLGEDYLFS..DIKYINVTVQE.QFTKKDTTFSNVAVEYTE...........KLDg........ngTKISVAVSDSIFR.LSAGKYKVKNYTTIKKNK.....GSLEYG..E-VNGADFEVSDNV-t........................
A0A108T7M6_BACSE/41-154              .................GHVQFRLYKSASytqee.....ttragTASTRA....-TAMDRLS..DAQKVEIEM--.QHNGMSITQTLVLNAYNE...........---...........SNAEYGMRSDKLE.LLTGTYKIVGYKLLDKLD.....EVITGI..SPGADETFEVVSRG-l........................
A0A108T6M3_BACSE/159-273             .................GKISFNLIKDLSnyqee.....mdkvnNASTRA...tAKDETLFQ..YDQIAEVDVTY.KMGSQVARTSQAKVYLAT...........---...........-DADYF-HTDTLS.LVAGEYTVTEVKYYDKKR.....QNLLLV..T-NPNIEITVAPN--vl.......................
A0A3L7Z266_9BACE/160-283             .................GTVTFKLTKTG-...............LPETRA...tGDASYLFK..DIKLIDVTVTN.TFTRESTTFKKLKVAYKEeyk.....eheNPDnpn.....dkyMDIGVATSDSAVW.LPTGNYRVTAYTTYRKSGa..veTSLETQ..E-VAGEPFAIKDNRL.........................
A0A1Y3VII0_9BACT/38-148              .................GYIQFKIYKEASyp..........gapASQSRA...vVDELDYLH..AARKLSVEL--.RSGNTSIVQTMVLSAADN...........---...........QSAEFGLRSDKLQ.LLAGEYQIVSFSLYDVDD.....EEIYRG..TPDHS----------nnnnivniva...............
R6DGD6_9BACE/39-143                  .................GYVQFKLIKKAS...............SSESRAa..aIDKLEKLD..DAKKIKVVM--.EHNGTTVSQTLVLNSYNA...........---...........DNAEYGLRSDKLQ.LTSGTYTVIGFYLYDAVD.....EELLAS..S--ADNTFNVIGGG-m........................
R6DIK5_9BACE/158-278                 .................GTVTFKLTKEG-...............-LTTRA....-AGEYLFS..DIRFIKVTVMN.TFNRVTTELKDMKVTYKEdsk.....eheNPDnpn.....dkyMDIGVATCDSAVW.LPAGTYQVVAYTTYTKSGs..tkKELETQ..P-VRGEPFIVKDNEL.........................
R6NMJ2_9BACE/165-285                 .................GSVKFKLEKQL-...............-PQTRA....NSEGYLFS..DIQLATIQVQN.TFSQVTYKFEKLKARYEEey......eltNPDsen.....dkyKDHGVAYCDSAVW.LPAGDYKVISYTVYTKQGv..teTELETQ..A-VSGETFTVKDNQL.........................
A0A3L7Z266_9BACE/41-147              .................GYVQFKLYKSASy............akGGETRA....-GDLNKLG..EAQKVEIEM--.LYNGASITQTLILNAYNE...........---...........SNAEYGMRSDKLQ.LLVGDYKVVGYKLLDKLD.....EVITSI..SASSDETFTVVSRG-l........................
A0A4Y1X0R2_9BACT/168-292             .................GSVRFTLTKDMSgf...........npPARTRS...dIPRQYIFE..EIGKFDVTVKN.TETNNLVTFEQLPVTFSIhf.......ddE-Enae....tppgYQTSTCACDSLLS.LPAGNYVVLRYLTYDSDG.....ILLETN..NSPVESPFTVEDNR-t........................
A0A173WWD7_9BACE/39-147              .................GYVQFRLLKSASm............dkGTTTRA...vTDKLDKLN..DAQKVKVVM--.QYNGSTITQTLLLNAYNA...........---...........ENAEFGLRSDKLK.LLTGTYTVIGYYLYDKLD.....NVLYAG..PAGENNAFAIVSDG-l........................
Q8ABA0_BACTN/39-146                  .................GYVQFKLYKSTSf............ekGTTTRA....VGKLESMS..SAQKIKVVM--.THNGTTVSQTLLLNAYNA...........---...........NNAEYGLRSDKLQ.LLAGTYKIVGYYLYDGLD.....EVLLAG..PAGDDNELTVVSGGL.........................
A0A255SXE6_9BACT/39-151              .................GYVQFQLLKRGVadgtk.....avgtkSDGTRA....TSQLERLD..DAKKIKVVM--.VSDGNTISQTLPLTAYNA...........---...........ANAEYGLRSEKLK.LAAGKYTIVGFYLYDAVD.....EELLAS..S--SGEQFTVVGGG-m........................
A0A174JDN5_9BACE/36-140              ............gylkl-----MVAPQT-...............STATRA....--GGLSLS..NVRKVEVSM--.LYGDLPVTQSLNLSSAEG...........---...........-AAELGLESEKLE.LRAGEYKMQSYILYGTAK.....------..---------------pgaetpemlmtvyldevvpfsisng
A0A173XHS4_9BACE/39-147              .................GYVQFKLYKSIEd............geESATRS...tTDKLDFLN..DAKKMQVVL--.LHNNTTITQSVPLNAYND...........---...........QLAEYGLRSDKLE.LFPGDYKLIGYYLFNKVE.....EKIFSG..EPAEPTTFTIQTGGL.........................
A0A4Y1X2H6_9BACT/174-306             .................GMVQFRLTKEGLpe..........igrAAATLAa.ddGDKSFLFS..NIALVSVTVKN.TFTQDEIDFEELKVTYEEqyee..spsadDPDd........kyKDVGTARCDSVVW.LPTGTYRVTAYTVYSKSGs..tkTALDTR..MGLQGKEFTVADNEL.........................
Q8ABA0_BACTN/159-279                 .................GTVTFKLSKEG-...............-ISTRA....-AGEYLFS..NIRYVDVTVMN.SFNRVTTELKGMKVTYKEdsk.....ehqNPDnan.....dkyMDIGVATCDSAVW.LPAGTYQVVAYTTYSQSGi..krSELETQ..S-VRGESFTVIDNKL.........................
R6C1A8_9BACT/39-143                  .................GYVQFKLSKKVS...............SRATRAt..aLDKLEKLD..DAKKIKVVM--.EHNGTTVSQTLVLNSYNS...........---...........ENAEYGLRSEKLQ.LASGTYTVIGFYLYDAVD.....EELLAS..S--AGETFTVVGGGL.........................
R6NMJ2_9BACE/40-152                  .................GYVQFKLYKEASynngt.....eaatqSAATRA....--AVDSLG..EAKKIEVEM--.LYNGTSITQTLVLNAYND...........---...........ENAEYGLRSDKLQ.LLVGDYKIVGYRIYDKLD.....QVITGI..SADADEMFTVVPSGL.........................
A0A4Y1X0R2_9BACT/36-155              .................GYVQFRLYKEASydssrtdepqadafrTAGTRA...vKPQLDYLA..EASKVQVTL--.TCGEQTIIQTLTLSAADK...........---...........ESAEYGMRSDKLK.LLTGEYEIARFTLFDSND.....EELYNG..N-AADTRLTVVSGGL.........................
A0A108T7M6_BACSE/167-297             .................GMVTFKLIKSG-...............-LTTRAa.dgESIDYLFS..DIKVIDVTVTN.TFTRVPVTIKNLKVTYKEeye.....ehpNTDytddnkhkdkyKDIGTAKCDSAVW.LPAGTYQVTSYTIYKKSGs..vtSTLDSR..SQLAGEMFSVEDNR-q........................
A0A174JDN5_9BACE/155-270             .................GKVYFDILKDLSnykee.....tdkanQGVTRA...fDQDPELFSydDIAEVDLYYKK.KGSSERVDYHSFKVYTKK...........---...........--GEKCLHTDTVStWEAGEYEITRYMLYSDKR.....TNML--..---------------lagdlkdtyvnvap...........
R6XX68_9BACT/39-143                  .................GYVQFKVSKSVS...............PRATRAa..aLDKLEKLD..DAKKIKVVM--.EHNGTTVSQTLVLNSYNA...........---...........ENAEYGLRSDKLQ.LASGTYTVIGFYLYDAVD.....EELLAS..S--AGETFTVIGGGL.........................
R6XX68_9BACT/156-277                 .................GKVKFNLVKEW-...............-EKTRA....ANQEYLFS..NIRLVDISVTN.LFTRETVTFSNVKVTYEEdsk.....enqNPDnad.....dkyMDIGKAYCDSTVW.LPAGTYQVTSYTTYGKTGa..vkTKYETQ..P-VKGEAFVVEDNQL.........................
A0A2T5C643_9BACT/162-275             .................GKLQFSLKKNFV...............-ADTKSa..dNADRYRFD..EVAYATLYVQN.EFTMAEEVFEMVPFEYAEk.........lSED..........gVLYAVATSDSIFT.VRAGSYSVVSYVLYDKSK.....KMVDGD..RVLLDGSFQIADNQ-q........................
R5UX62_9BACT/36-141                  .................GYVQFKLYKEAS..............yDAVSRA...qKPQLDYLY..EAAKVQVSL--.GCNGTTVTQTLTLSASDK...........---...........ESAEFGLRSEKLR.LLTGQYQIITFSLYNAND.....ELIYNG..MPLD-DRLVVEAGGL.........................
A0A173WWD7_9BACE/160-283             .................GMVTFKLVKDF-...............-VKTRA...tGEEAYPLS..NILAIDITVKN.LFTQELTTIKSIRVKYVEdftdkpaedyvD-Ad........rnQETSYMECDTVAW.LKAGTYQISSYTTYSDKKa...kNILEVA..TVQTSKSFVVKDNE-v........................
R5UX62_9BACT/154-274                 .................GKVRFTIRKDLSdf...........teTPVTRA....ANRQYTFD..EIAFISLTVKQ.GETNEQTTFKMLPTKFSIh.........fDEDdd......tfgYQTSSLECDTLLS.LKAGSYKMMRYETYDKNK.....LLLENN..KRPKNLDFVIEDNK-t........................
R6C1A8_9BACT/156-277                 .................GKVKFNLVKEW-...............-EKTRA....GGAEYLFS..NIRLVDVSVTN.LFTRETYTFPELKVKYKEgsk.....enqNPDnen.....dkyMDTGTAYCDSTVW.LPAGTYQVTSYTTYGKTGa..vkTKYETQ..P-VKGEAFIIEDNQL.........................
R6DGD6_9BACE/156-277                 .................GKVKFNLVKEW-...............-QKSRA....GEGEYLFS..NIRLIDVNVTN.LFTRETFTFPNMKVKYKEmse.....ehqNPDnan.....dkyMQIGTAYCDTTVW.LPAGTYQVTSYTTYGKTGa..vkTKYETQ..P-VNGKSFIVKDNQ-f........................
A0A173XHS4_9BACE/160-283             .................GLVKFKLVKDFYe............gtSENTRAggngGGKTYLFS..EIAKVDIKVRN.RYTQQDSTFTNLKVKYKEgfdg...teagS--...........PGMAVGVIDTLVT.LEAGEYEVISYTTYNKTS....kIPLEST..ASLKENSFIIKEGE-e........................
A0A2T5C643_9BACT/39-147              .................GYAQFKLFKSASy.............kKLASTG....SNELDYLG..QAEKMKIVMTN.NQDGSELIQTVGLNQLGD...........---...........-DAEQGLRSEKLK.LMAGSYTVVGFYLYQIEG.....QELTLV..LSGEPEEPTVID---vvgg.....................
R6DIK5_9BACE/39-145                  .................GYVQFRLFKSASf.............eGTTTRA....TDKLESLS..NAQKIKVVM--.EHNGTTVSQTLPLNAYNE...........---...........NNAEYGMRSEKLQ.LVVGTYKIIGYYLYDKLD.....EVLLAG..PGGDDNELNVVSGGL.........................
A0A374CK64_9BACT/156-277             .................GKVKFNLVKEW-...............-EKTRA....GNTEYLFS..NIRLIDISVTN.LFTRETFTFPGVKVKYKEase.....ehqNPDden.....dkyMEVGTAYCDSTVW.LPAGTYQVTSYTTYGQTGa..vkTKYETQ..P-VKGEAFIVEDNQL.........................
R5VC81_9BACE/41-154                  .................GYVQFKLYKSASyvepe....tggetsAQLSRT....--DVDKLG..DAKKIEIEM--.QFEGTSITQTLVLNSYNE...........---...........ANAEYGLRSDKLQ.LVVGEYRIVGYRLLDALD.....RVLTGI..PADPDESFTVVSGGL.........................
A0A174PVX0_9BACE/42-135              gevtfkfvrnkvytist------------...............------....------LE..DMARLKVTL--.EKDGQKVTLPTIDLIGDI...........---...........----DSLTSSAVR.LENGDYKVVKYTAYNNKG.....VQVQEA..YLDDNNTLSVEHG--vm.......................
R6VIB4_9BACT/28-143                  .................GYVQFKLYKEASyvaps....deatqqQMQTRA...aKPQLDYLA..EASKVRVTL--.SYGDQTIVQTLTLSSTDS...........---...........ENAEYGIRSGKIK.LLTGNYEIVRFTLFDNND.....DELYNG..NATDP-SLTVIPGGL.........................
E5C3L2_9BACE/25-138                  .................GYAQFKLYKSCLa.............eTKVTRA...sTNELNYLR..DAQKMKIVLIN.QEDGTEVVQTVGLEAMGD...........---...........-DSEFGLRSEKLQ.LMAGTYQIVGFYLYKADGttqdlKQILSG..EPDEKTIITVINGGL.........................
R6VIB4_9BACT/156-281                 .................GKVRFTLTKDMSgf..........tppTSSTRA...nISREYIFE..EIGKFDVSVKN.TETNNIVKFEQLPATFSIh........fdDPEnte....tpegYQTSTCACDSLLS.LQAGNYIVIEYRTYDSDG.....ILLETN..NAPVESPFTVEDNR-t........................
I9RNR0_9BACE/36-147                  .................GYMQLQLHKKG-...............-ADSRAl.dsGKELSYLK..DVRKIQITL-A.SAGNQSFSMALMPKSVSE...........---...........EGAEFGLSTVPVQ.LMPGTYKITYFVVYGDEVvdgqaEILQSG..TPDEEVNFRIENNRL.........................
A0A4Y1X2H6_9BACT/44-161              .................GYVQFKLYKLASydkdtggettqrqtsQAFTRA....--GADKLG..DIRKMEIEL--.RYGETSITQTLILNSYNE...........---...........ENAEFGLRTDKLQ.LLAGEYRIVGYRLLDKLD.....EEIPNA..AAPIDEAFTVVANGL.........................
#=GC seq_cons                        .................GhVpF+LhKcs.................tsTRA....hsp..hhs..-hpclcVsl...pasppolo.shlhssYsc..........................ssphuhpssplp.L.uGsYplsuYplYspss.....ptL.st..s.stspsFsVhsst..........................
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