#=GF ID   DUF5089
#=GF AC   PF17002.9
#=GF DE   Domain of unknown function (DUF5089)
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   c_1437 - Hirt RP, Nakjang S
#=GF GA   36.10 36.10;
#=GF TC   36.10 41.10;
#=GF NC   35.30 35.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   24259309
#=GF RT   Reduction and expansion in microsporidian genome evolution: new
#=GF RT   insights from comparative genomics.
#=GF RA   Nakjang S, Williams TA, Heinz E, Watson AK, Foster PG, Sendra
#=GF RA   KM, Heaps SE, Hirt RP, Martin Embley T;
#=GF RL   Genome Biol Evol. 2013;5:2285-2303.
#=GF DR   INTERPRO; IPR031547;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This is a family of microsporidial-specific proteins of unknown
#=GF CC   function. There is distant homology to synaptosomal-associated
#=GF CC   25 family proteins.
#=GF SQ   32
#=GS L2GKU5_VITCO/36-226      AC L2GKU5.1
#=GS R0MMX7_NOSB1/52-241      AC R0MMX7.1
#=GS T0L731_9MICR/43-224      AC T0L731.1
#=GS L2GXU5_VAVCU/28-216      AC L2GXU5.1
#=GS I3EJJ6_NEMP3/12-193      AC I3EJJ6.1
#=GS A0A0F9Z9W4_9MICR/23-211  AC A0A0F9Z9W4.1
#=GS Q8SWC4_ENCCU/22-211      AC Q8SWC4.1
#=GS A0A2H9TPH8_9FUNG/37-232  AC A0A2H9TPH8.1
#=GS A0A4Q9LNA0_9MICR/1-135   AC A0A4Q9LNA0.1
#=GS A0A177EHK5_9MICR/29-225  AC A0A177EHK5.1
#=GS A0A4Q9LH67_9MICR/35-233  AC A0A4Q9LH67.1
#=GS T0MMA4_9MICR/46-99       AC T0MMA4.1
#=GS A0A059F4T5_9MICR/22-199  AC A0A059F4T5.1
#=GS B7XI70_ENTBH/26-216      AC B7XI70.1
#=GS H8ZA02_NEMS1/12-193      AC H8ZA02.1
#=GS A0A0B2ULZ5_9MICR/21-209  AC A0A0B2ULZ5.1
#=GS A0A0R0M6X8_9MICR/28-215  AC A0A0R0M6X8.1
#=GS L7JZ03_TRAHO/28-215      AC L7JZ03.1
#=GS A0A437APD1_9MICR/20-197  AC A0A437APD1.1
#=GS A0A1Y1S720_9MICR/25-217  AC A0A1Y1S720.1
#=GS A0A059EJ14_9MICR/1-112   AC A0A059EJ14.1
#=GS J9DME2_EDHAE/28-220      AC J9DME2.1
#=GS I3EKI6_NEMP3/33-231      AC I3EKI6.1
#=GS A0A1W0E4N9_9MICR/26-217  AC A0A1W0E4N9.1
#=GS A0A1X0Q790_9MICR/27-221  AC A0A1X0Q790.1
#=GS A0A177EET7_9MICR/12-193  AC A0A177EET7.1
#=GS L2GJL6_VITCO/21-211      AC L2GJL6.1
#=GS A0A4V2JXX9_9MICR/4-202   AC A0A4V2JXX9.1
#=GS C4VA68_NOSCE/34-222      AC C4VA68.1
#=GS S7WA16_SPRLO/24-220      AC S7WA16.1
#=GS A0A4V2JX03_9MICR/35-220  AC A0A4V2JX03.1
#=GS H8Z905_NEMS1/16-213      AC H8Z905.1
L2GKU5_VITCO/36-226                 .......EEAAKKATKIEKGS.YNRARKARKKLEEAEQKQKMTTEEVRKQNESLEHGRQGAFKVHEEAEKAKDTAITLEKERNAFDILAPAKAKYGKWAAKDAQ..AAAEIEQMKNKSSEQ.......L-------.-ENEAM.SENKELgnlnakTEAEAKTNKELQKIYKSVKRINKETEVQSRESKKQKSKLGDIMKTSEYAKKSVKETDEKLRK..
R0MMX7_NOSB1/52-241                 .......EDILQEAQQVEEEN.YQTAKDIRMQIGSAAIEQKGATEEMRRQGETLDAAKRAAVGVHREARRGDVLADDIEREGHFFNFRCACLEKLFGWFRKDPN..-DEKVEEIANKEVKS.......MGDSSY--.EREDFV.PAEKEM......VPGQNKTDKELNEILNTVKGIRSEAELQGEEAQRQKTVVKDISAVNEQAEKVIKRTDTKLKK..
T0L731_9MICR/43-224                 ......t-SIIQQAEQIEHQN.YNEAHNIKKQLTQAHLNQKEATNEMKRQTETLSHTKKSAHGIHQEAQKGESLADDIDREGRIFSCRFACIDKLFRWFRKT--..---EVKDEKEKTYDE.......-----PEV.KY-EEY.KDEDEF......VPGQNQTDKELVGVLNVVRGIRQQAEVQSNEADKQKICIGDIKNVNEESEKVIKRTDEHLKK..
L2GXU5_VAVCU/28-216                 .......EEVEARAKQIEEQN.YEMAHGARKKLESGYATQQKTTKELYSQGEKLDKAETGARDIEKNVEEGKHLTHKIKEEGKMFNFRLPFVGKFKKIFKSKKE..PEPAAHKRKSERAAA.......D----KPK.KDESEI.VTDKNL......IPGQAKTDKELEQIYRTLKNVKGEAKVQQEEMTRQRENMKSIGKRTQKSEKEMENVTEELKK..
I3EJJ6_NEMP3/12-193                 .....dn--YLEE---LESVN.YKTSLEAKKTLNSILRTTDKTTAMLYEQREVLEDIRNDSYTAKDNLEKSKGLTVKMKRAGKLIVIGDKVSDKLKSIFKSAPK..PKQNFPSFTSPTDHA.......------AP.DSEEFP.TEEKEI......--TKETTNDVLISIRNGLKTLHSKLDKQNKELNSQNPLIQDITETNKKSSTEAEKVMKSLKK..
A0A0F9Z9W4_9MICR/23-211             .......NSILKEAKRIEEEN.YEQAKDIRMQLGQAAIEQKQASDEFRRQGEVLDNAKKSAINVHKEAKKGEELAEDIEREGSIFSCRFACFDRFCRWLKGDSG..-SQEVEEIESKKYDY.......--EEAPPV.QEEEFH.P-GEEF......VPGQNNTDKELVGILNTVKGIKQEAELQSREAAKQKSTIKDINRVTEQSEKVIKKTDEHLKE..
Q8SWC4_ENCCU/22-211                 ......q-DVVEEAERIEEQN.YERAKGVRMQLDESALKQKATTEELMRQGETLENAKKAAIGINTNARRGSELTEDIDREGRVFSCELPCVRTIKRWFRGNRG..---NIDDIVDRNQDS.......GSESERMP.ERVEFE.EDGEEY......IKGQNKTDREMVGVLNAVRQIRAEADKQNKESARHKSIVNDISMINERSEKVIKDTDKELKK..
A0A2H9TPH8_9FUNG/37-232             railmes-------KAVQKDT.LISTQNSVRTIKETIVVADKTSATLNAQGEQLDRIENKAETADANATDSYASARELHKYKGFIPLSLKN------TFTGGKKreEDSKLKSMNKKLDREegrldreAETNRPNL.AGTPKT.AGDSGG......DETERQINENLDEISAGLDHLQAQATSMNQELSRQNVSIKRVEATTEHTDYTINSANRKI--qe
A0A4Q9LNA0_9MICR/1-135              ......k--------------.---------------------------------------------------ITKDIKREGKLFGFHVPLIGKIKHLFSSDRK..IEKEVEVEKERLKHKkn..rstERIQEISS.DDEHFNqNSDDEV......VKGEGMTNKELYKISNKLKEMNSEAEIQKSELKKQKGDIKKISKVNENSEQIMDRTTEELKK..
A0A177EHK5_9MICR/29-225             ellqkkk-------TATEDES.FDIIRRANKGLGGTLKTSADTSKSLKHQGHSLETAASKKKKVRDIVTHSEVTVRDIKRSGHILDFSNSFFDSIACLFSAERR..EKARVEAQAKEEEAKat...sqESHSTDED.VDNHSE.IEQLEE......SDPDDDVDAELEKTLAGLQALRKDVKSQTHHIKAQAHATKEMAILDKDTNKRAKSLTKKIKK..
A0A4Q9LH67_9MICR/35-233             .......EEIKRRAEELEAEN.YDVAKQARMKLEASGTQQKDTTGRLKSQGEKLRNIKGEAIEVHEGAVKGAKITKDIKREGKLFGFHVPLIGKIKHLFSSDRK..IEKEVEVEKERLKHKkn..rstERIQEISS.DDEHFNqNSDDEV......VKGEGMTNKELYKISNKLKEMNSEAEIQKSELKKQKGDIKKISKVNENSEQIMDRTTEELKK..
T0MMA4_9MICR/46-99                  ......t-SIIQQAEQIEHQN.YNEAHNIKKQLTQAHLNQKEATNEMKRQTETLSHTKKSA-------------------------------------------..---------------.......--------.------.------......--------------------------------------------------------------h.
A0A059F4T5_9MICR/22-199             .....le--IQEHIKKVEQEN.FDIVVHQREKLKEAHKKQKQTTQDLLKQGEQLSNISKTAGRIYKKSKEGEKTTEDIKREGRFFKFPK-IFTKIKEIFKPKDK..----VLENINKKKEK.......--------.-KSEYK.PSELDS......-KTGATTDDNLKLLLGDLRQMRKEAEFQNKEINKQKVDINHISKVSKESEHIMSKTTQELRK..
B7XI70_ENTBH/26-216                 ......n-VILEEAAKIEQMN.YQKAKQARQNLEKAIDTQKETTQTIRAQGEKIFKAKQSAVRAHQNAIAANDLAVELHENRSAWAFNCGCLTGIKQWCARERN..-PTDVDALLNKNQEE.......ISSTEE-V.SVEEYN.PNGEEY......VKGEHQTNAELSKILHGLKRINKEADVQTKLATQQKSDLESIAQANEYTQRQVEKTNQRLNK..
H8ZA02_NEMS1/12-193                 ......e-DCLEE---IEAQN.YKTSLEARKTLNSILRTTDKTTNMIYEQREVLEEIRDESYFARDNLEKSANLTVKMKRAGKLLVVGDKVSDKIKSLFKSAPK..PKQDYPNSITPADTA.......------QE.RIEEFF.PEDKSA......--VKETTTDVLMSIRNGLKTLHTKLANQNKELKNQVPLIEDITETNAKSSTKAEKVMKSLRK..
A0A0B2ULZ5_9MICR/21-209             ......q-DVIEEAERIEEEN.YERARNIRVQIDESALKQRATTEEMLRQGETLENAKKSALEINRNAVRGAELTEDIEREGHMFSCELPCVRAIKRWLNRNRG..---DVSDVARTREVR.......-EVDEESR.GTVMFE.EDGEEY......VKGQNKTDKEMVGILNAVKQVNKEAKRQNREIERHKGIVDDISIINERSEKVIKDTDKELNK..
A0A0R0M6X8_9MICR/28-215             ......i-EIEQKAKEIEQQN.YQMAKAARIKLEQGYSTQKKTTKELLSQGEKLEKASADAEEIDENIQEGKYLAKKIEEEGKLFNFKVPFLGTIKNAFTSEKK..-KTKEKQQKVKNLPP.......----KEIT.SINSLN.IPKKNL......LPGQEKTDEELAKIYLTLKNVNQGAKFQHEEIERQQKNIKNISDRSKKSKDNMEEVEEKLK-n.
L7JZ03_TRAHO/28-215                 .......EEVEARAKQIEEQN.YEMAHGARKKLEAGYATQKKTTKELQSQGEKLERAEMSARSIEQDVEEGKHLTRKIKEEGKMFNFKLPFVGRIKKIFKSKKQ..PGHAVHTHKKERQAA.......-----PKP.QDESEI.VTDKNL......IPGQQKTDKELEQIYRTLKNVKGEAQQQHEEMARQTQNIKSIGKRTQKSEKEMENVTEELKK..
A0A437APD1_9MICR/20-197             .....le--IQEQIDKVEQEN.YDIIAHQRXKLKGAHQKQKQTTQELLKQGEQLQTISKTAGRVYKKSKQGQKTTEEIKREGSFFKMP-KFFSKIKNIFKPRDK..---VIEEIDKKKEKK.......--------.--GNYE.PTELDS......-KTGATTDENLKLFLNDLRTMRKEADVQNQEIKKQKVDIDQISKINKESEQIMNKTTQELRK..
A0A1Y1S720_9MICR/25-217             .....dk-HIMQEAEKIEEQN.LQKAKQARMKLEEAAETQKGTTQTMRAQGEKIIDAKKSASKTHKNAKAANDLAIDLHENRNAWAINCGCITSIKKWCSREGG..EEEAMSGLK-RNRGG.......TVKDNDEE.SSEVIE.VEGEEY......VKGANKTDTEMKKILHGLKKINKEADVQTKVAGKQKTDLEDISKANEYTKKEVDATNKRLEK..
A0A059EJ14_9MICR/1-112              .......--------------.----------------------------------------------------TEDIKREGRFFKFPK-IFTKIKDIFKPKDK..----VLENINKKKEK.......--------.-KSEYK.PSELDS......-KTGATTDDNLKLLLGDLRQMRKEAEFQNKEINKQKVDINHISKVSKESEHIMGKTTQELRK..
J9DME2_EDHAE/28-220                 .......EEILEKAAQIEHET.FLTAKQARQKLQQSAKQQQKTTISLEAQDEKLENIRMSAYQAKANAKDGEQLAKDIKQAGKVFGFNIPVVSSIKRYFSKGAK..MDRELLEQQRRNKNI.......GEFSADQD.EHTDKI.NRQVED......NDDIDPTDKELMLILDELKGMKGESKKQNYLIKSHKTKIEEIAKVNKNTEHYISKTNKKLKD..
I3EKI6_NEMP3/33-231                 .......DSSTSSNDRVENSDlFDIIKKANKGLAGSIRTSKDTTKTLNKQGKSLNKSLQKKKSIRKRVGKDEDLVRNINAEGNIVVIKSSFLDRLRNFFSPQKW..HEASVDQSAKREEERae..ecsKDEESDGL.SSEDEI.ADNLEN......TGSDEDVDAELEKTLTGLQSLRRSVHFQTQKIKSQRHAAKEMQLLDEDTSKRAKKLEEETKH..
A0A1W0E4N9_9MICR/26-217             .....at--ILEEAERIEQQN.YQKAKQARLELERAADTQQQTTQTMRAQGEKIGMAKTSAEKVNRNAKAANDLAIELEDNRSAFSCNFGCITGIKKWCSRDAG..EEEAVKGLKMNRSGA.......V-PETKQI.EENEYV.PEGEEY......IKGQHNTDKEMSKILHNLKKINAEADTQDKLAKQQKTDLEDIQRANAYTQKQVEKTDKRLN-d.
A0A1X0Q790_9MICR/27-221             ....dei--ILEEARVIEQRN.QQRAKAARQKLEKAGEKQKDTTKTMEAQGEKIKTAKGAAVRTYKKSREAEELSKQLEENQGTMGFTFPGWNKVKGWARTNTA..EDKEIEQLSNQKAEQ.......NQQSDPSEsSNLESS.KTEDEY......VEGAKQTDKELKGILGNLKSINEETEKQRKLGEEQRTDLQDINRVNEYSKKTQEKTDEKLKK..
A0A177EET7_9MICR/12-193             ..eedyl----K---EVERIN.YKTALEAKKTLDSITRTTEKTSAILYEQREKLEDIMNDAETIRDNIEKGKELSVKMKRAGKFITIGDKIGDKLKGMFKPGPP..PKRAPSELPTMPHEP.......-----ACP.TE----.PHAVID......SPTEDNTNAVLLSIRDGLKKLHSRLKTQDQEINNQIPLIKDIATINKSSTNEADKAIQNLK-q.
L2GJL6_VITCO/21-211                 .....ga--FIEEAQEIESQN.CLKAKSILAKMERTIDVQNETIQEIKLQGEKLVKIKESSIAVYKNAEAANEVSHRIRQESSIFPSFSNLFRGVKRWWKKDRR..GEKYIESIKNRKKED.......--VTAPAV.TEEVFE.PLNEET......VPGENKTDSELSKILTCVKKVEAGARTQLQILKTQDDDINDITKIGEYSKGIVDSTEKEMRK..
A0A4V2JXX9_9MICR/4-202              .......EEIKRRAEELEAEN.YDVAKQARMKLEASGTQQKDTTGRLKSQGEKLRNIKGEAIEVHEGAVKGSKITKDIKREGKLFGFHVPLIGKIKHLFSSDRK..IEKEVEVEKERLKHKkn..rstERIQEISS.DDEHFNqNSDDEV......VKGEGMTNKELYKISNKLKEMNSEAEIQKSELKKQKGDIKKISKVNENSEQIMDRTTEELKK..
C4VA68_NOSCE/34-222                 .......NSILKEAKRIEEEN.YEQAKDIRMQLGQAAIEQKQASDEFRRQGEVLDNAKKSAINVHKEAKKGEELAEDIEREGSIFSCRFACFDRFCRWLKGDSG..-SQEVEEIESKKYDY.......--EEAPPV.QEEEFH.P-GEEF......VPGQNNTDKELVGILNTVKGIKQEAELQSREAAKQKSTIKDINRVTEQSEKVIKKTDEHLKE..
S7WA16_SPRLO/24-220                 .......DEILQEASKLESQN.YSMAHSARKNLQSAQQTQKETGKELISQGEQLKNIEGDAKDTHENVKKSEQLTKDIKKEGKLIHFGNPF-SFVKKMFKKDDK..NERELKTTLNKKDESkh..ntyKSDKNNSK.NDKNLI.TTDKED......VPGEAKTNKELNMIYSTLKDMKKDASTQQQEIKKQKLTTERIGAYSKASEAKMKKTEEELKK..
A0A4V2JX03_9MICR/35-220             .......EEIKRRAEELEAEN.YDVAKQARMKLEASGTQQKDTTGRLKSQGEKLRNIKGEAIEVHEGAVKGAKITKDIKREGKLFGFHVPLIGKIKHLFSSDRK..IEKEVEVEKERLKHKkn..rstERIQEISS.DDEHFNqNSDDEV......VKGEGMTNKELYKISNKLKEMNSEAEIQKSELKKQKGDIKKISKVNENS-------------..
H8Z905_NEMS1/16-213                 .......DSSTSSNNEVDHDDlFDIIKKANKGLAGSVRTSKDTTKTLTKQGHSLKKSLHKKKNIRDSIGKDEKTVQNINAEGHVVVVKSSFFDKVKGFFSGKTW..HEEAVNQSAEKEEKKae..kysDEEEDDEFsSEESRV.AEDLES......TGSD--VSDELEKTLAGLQSLRRSVHFQTQKIKSQRHAAKEMQILDKDTTERAKQLEEEAKH..
#=GC seq_cons                       ........plhpcApplEppN.YphA+puRhpLppuhppQKcTTpplppQGEpLcphcpsAhplccpspcupclsc-Ic+EG+hFshphshhs+lKphFpscpp...cpplcp.tp+ppcp..........pt.t..pcpch..spscEh......s.upspTscEL.pIhssLKplppEAchQspEhp+Q+sslccIsclscpScchhccTsccL+K..
//