GenomeNet

Database: Pfam
Entry: DUF750
LinkDB: DUF750
Original site: DUF750 
#=GF ID   DUF750
#=GF AC   PF04721.12
#=GF DE   Domain of unknown function (DUF750) 
#=GF PI   PNGase; 
#=GF AU   Waterfield DI, Finn RD, Pollington J
#=GF SE   Pfam-B_4045 (release 7.5)
#=GF GA   21.30 21.30;
#=GF TC   21.30 22.10;
#=GF NC   21.00 21.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   17522090
#=GF RT   Unique peptide:N-glycanase of Caenorhabditis elegans has
#=GF RT   activity of protein disulphide reductase as well as of
#=GF RT   deglycosylation. 
#=GF RA   Kato T, Kawahara A, Ashida H, Yamamoto K; 
#=GF RL   J Biochem. 2007;142:175-181.
#=GF DR   INTERPRO; IPR006588;
#=GF CC   This family of proteins with unknown function shows similarity
#=GF CC   to PNG-1, a enzyme responsible for de-N-glycosylation of
#=GF CC   misfolded glycoproteins in the cytosol [1]. However, unlike
#=GF CC   PNG-1, this protein does not contain a catalytic triad in its
#=GF CC   transglutaminase domain [1].
#=GF SQ   98
#=GS NGLY1_CAEBR/439-500   AC Q5WNE3.1
#=GS O18169_CAEEL/358-419  AC O18169.2
#=GS G5EFH6_CAEEL/262-323  AC G5EFH6.1
#=GS E2R815_CANFA/494-557  AC E2R815.1
#=GS Q9GYU0_CAEEL/121-182  AC Q9GYU0.5
#=GS H2ZYD3_LATCH/496-560  AC H2ZYD3.1
#=GS NGLY1_CAEEL/444-505   AC Q9TW67.1
#=GS NGLY1_MACFA/493-556   AC Q4R6F3.1
#=GS G3WDQ8_SARHA/462-527  AC G3WDQ8.1
#=GS P91471_CAEEL/45-107   AC P91471.2
#=GS O45155_CAEEL/107-176  AC O45155.1
#=GS F7DQ39_MONDO/59-125   AC F7DQ39.1
#=GS E1BKB2_BOVIN/496-559  AC E1BKB2.1
#=GS G1QUL8_NOMLE/493-556  AC G1QUL8.1
#=GS NGLY1_RAT/489-553     AC Q5XI55.2
#=GS H9GEH0_ANOCA/504-569  AC H9GEH0.1
#=GS F6WC45_MACMU/493-556  AC F6WC45.1
#=GS Q9GYT7_CAEEL/312-375  AC Q9GYT7.1
#=GS G5BF99_HETGA/491-553  AC G5BF99.1
#=GS H0YZA2_TAEGU/490-553  AC H0YZA2.1
#=GS I0FTB6_MACMU/493-556  AC I0FTB6.1
#=GS H9F5X1_MACMU/491-554  AC H9F5X1.1
#=GS Q966B1_CAEEL/86-147   AC Q966B1.2
#=GS PAWC1_CAEEL/244-305   AC Q966B0.2
#=GS F6WCT2_MACMU/474-537  AC F6WCT2.1
#=GS P91470_CAEEL/288-349  AC P91470.2
#=GS NGLY1_HUMAN/493-556   AC Q96IV0.1
#=GS O18169_CAEEL/60-121   AC O18169.2
#=GS G5EFH6_CAEEL/81-142   AC G5EFH6.1
#=GS PAWC1_CAEEL/52-113    AC Q966B0.2
#=GS Q9N4T3_CAEEL/291-352  AC Q9N4T3.3
#=GS O76682_CAEEL/460-523  AC O76682.2
#=GS H3DLD9_TETNG/476-539  AC H3DLD9.1
#=GS G3RSV6_GORGO/495-558  AC G3RSV6.1
#=GS G1T9A3_RABIT/452-515  AC G1T9A3.1
#=GS D2HUZ7_AILME/492-556  AC D2HUZ7.1
#=GS Q1ZXR7_CAEEL/102-154  AC Q1ZXR7.1
#=GS G1QUM4_NOMLE/474-537  AC G1QUM4.1
#=GS O76676_CAEEL/328-391  AC O76676.2
#=GS P91472_CAEEL/499-561  AC P91472.3
#=GS P91472_CAEEL/298-359  AC P91472.3
#=GS O76677_CAEEL/260-321  AC O76677.2
#=GS H2ZYD2_LATCH/467-531  AC H2ZYD2.1
#=GS A3KQW7_DANRE/483-546  AC A3KQW7.1
#=GS O45155_CAEEL/648-709  AC O45155.1
#=GS Q08B23_XENLA/474-538  AC Q08B23.1
#=GS O76677_CAEEL/457-520  AC O76677.2
#=GS G7NY95_MACFA/452-515  AC G7NY95.1
#=GS F7D099_MONDO/492-555  AC F7D099.1
#=GS G3WDQ9_SARHA/458-523  AC G3WDQ9.1
#=GS NGLY1_CHICK/488-553   AC Q5ZJM3.1
#=GS P91472_CAEEL/98-159   AC P91472.3
#=GS F7DQ31_MONDO/476-539  AC F7DQ31.1
#=GS O76682_CAEEL/673-734  AC O76682.2
#=GS G1NF31_MELGA/451-514  AC G1NF31.2
#=GS O45155_CAEEL/464-519  AC O45155.1
#=GS H2VWB9_CAEJA/21-82    AC H2VWB9.1
#=GS H3DWH0_PRIPA/17-75    AC H3DWH0.1
#=GS G3TBR2_LOXAF/495-559  AC G3TBR2.1
#=GS O76682_CAEEL/107-175  AC O76682.2
#=GS O18173_CAEEL/253-314  AC O18173.3
#=GS P91470_CAEEL/81-142   AC P91470.2
#=GS G1NW75_MYOLU/453-516  AC G1NW75.1
#=GS F6PR92_CALJA/452-513  AC F6PR92.1
#=GS O18170_CAEEL/85-135   AC O18170.3
#=GS NGLY1_DANRE/483-546   AC Q503I8.1
#=GS E3NHL0_CAERE/215-276  AC E3NHL0.1
#=GS NGLY1_MOUSE/489-553   AC Q9JI78.2
#=GS NGLY1_MOUSE/489-553   DR PDB; 2G9F A; 489-553;
#=GS NGLY1_MOUSE/489-553   DR PDB; 2I74 B; 489-553;
#=GS NGLY1_MOUSE/489-553   DR PDB; 2G9G A; 489-553;
#=GS NGLY1_MOUSE/489-553   DR PDB; 2I74 A; 489-553;
#=GS O76676_CAEEL/123-184  AC O76676.2
#=GS F7FGS1_ORNAN/453-517  AC F7FGS1.1
#=GS O18170_CAEEL/245-306  AC O18170.3
#=GS H0WKM6_OTOGA/494-557  AC H0WKM6.1
#=GS H2SWE9_TAKRU/473-539  AC H2SWE9.1
#=GS F6VBL0_HORSE/416-479  AC F6VBL0.1
#=GS O45199_CAEEL/157-204  AC O45199.2
#=GS H2PBB4_PONAB/476-539  AC H2PBB4.1
#=GS Q966B1_CAEEL/269-330  AC Q966B1.2
#=GS F1LLZ5_RAT/455-519    AC F1LLZ5.1
#=GS P91459_CAEEL/101-131  AC P91459.2
#=GS Q9N4T3_CAEEL/113-175  AC Q9N4T3.3
#=GS F1RS44_PIG/477-540    AC F1RS44.1
#=GS Q9GYT3_CAEEL/84-144   AC Q9GYT3.2
#=GS H2QM74_PANTR/493-556  AC H2QM74.1
#=GS Q9GYU0_CAEEL/326-389  AC Q9GYU0.5
#=GS Q9GYT7_CAEEL/107-199  AC Q9GYT7.1
#=GS O76677_CAEEL/84-144   AC O76677.2
#=GS B4MYN5_DROWI/514-555  AC B4MYN5.1
#=GS G3QJW4_GORGO/494-557  AC G3QJW4.1
#=GS F1NWD4_CHICK/488-553  AC F1NWD4.1
#=GS F7FGJ8_ORNAN/448-512  AC F7FGJ8.1
#=GS Q9GYT7_CAEEL/521-582  AC Q9GYT7.1
#=GS H2ZBE2_CIOSA/96-159   AC H2ZBE2.1
#=GS G0NIJ2_CAEBE/445-506  AC G0NIJ2.1
#=GS Q4RIW3_TETNG/472-535  AC Q4RIW3.1
#=GS G7MJY5_MACMU/452-515  AC G7MJY5.1
#=GS Q7QJB1_ANOGA/546-594  AC Q7QJB1.4
#=GS C0PUG1_SALSA/191-254  AC C0PUG1.1
#=GS F7AI61_CALJA/496-557  AC F7AI61.1
NGLY1_CAEBR/439-500              .......ANHVEFSYDVNRDSY.....SQTPE.....K.....GFVAQ.....TFE.....CNNIQRKVE........NDWKMVYLCR.EDGKKEGN........................ISWHFN......................
O18169_CAEEL/358-419             .......DNYVKFTYNVISNTY.....SQTHE.....D.....GSKID.....SFY.....VFNIERVED........RSLNQVYLRK.RNTLFMGS........................ITWQF-i.....................
G5EFH6_CAEEL/262-323             .......ENSAKFKYNFINNSY.....SHTQP.....D.....GSPIR.....LFN.....FNGMERVED........YTESDVFLRR.EIPEKKGN........................IGWALD......................
E2R815_CANFA/494-557             ...lhlc-------YNIVKDRY.....VRVSN.....N.....NQTISgwengVWK.....MESIFRKVE........ADWNMVYLAR.REGSSYAY........................ISWKFK......................
Q9GYU0_CAEEL/121-182             ......y-NYVKFTYDILNNTY.....SHDNE.....D.....GSPVA.....PYF.....VDKIERVVD........RKKNEAYLHQ.EFPDDFSN........................MYWAFN......................
H2ZYD3_LATCH/496-560             ...vlhl------KYNTATDCY.....IRLSN.....D.....NEEIKgwekgVWK.....MESVFRKVE........NDWQMAYLAR.TEESSLGR........................ISWKFE......................
NGLY1_CAEEL/444-505              .......QNYLEFNYDVITDTY.....SQPPE.....I.....GFSAQ.....AFE.....LENVQRVEE........TDWNMTYLCR.KRGDAPGN........................ISWHFD......................
NGLY1_MACFA/493-556              ...lhlc-------YNIVKDRY.....VRVSN.....N.....NQTISgwengVWK.....MESIFRKVE........TDWHMVYLAR.KEGSSFAY........................ISWKFE......................
G3WDQ8_SARHA/462-527             ..klfhl------TYNPVDDCY.....VRVSS.....NndkisGWESG.....VWK.....MESVFRKVE........TDWKMVYLAR.KEGSSSGY........................ISWKFE......................
P91471_CAEEL/45-107              .......ANYVKFWYNIVRNTY.....SQTHT.....N.....GSPVK.....PYL.....VANIERTID........TRLGEVFLHK.KERSEHWA.......................sIAWFFN......................
O45155_CAEEL/107-176             ......a-DYATFEYNVTSDEY.....LRLND.....D.....GTKIQ.....PWI.....VKNIERKVKfyyfesisAIEQTAFIHK.IEPNEDGV........................IYWKFE......................
F7DQ39_MONDO/59-125              aklfhiv-------YNPVEDYY.....VRISS.....NnetisGWLSG.....IWK.....MESIFRKVE........TDWNMVYLAR.KEGSPSAF........................ISWKFE......................
E1BKB2_BOVIN/496-559             ...lhlc-------YNIVKNYY.....VRISS.....N.....NQTISgwengVWR.....MESIFRKVE........TDWNMVYLAR.KEGSSYAY........................ISWKFE......................
G1QUL8_NOMLE/493-556             ...lhlc-------YDIVKDRY.....VRVSN.....N.....NQTISgwengVWK.....MESIFRKVE........TDWHMVYLAR.KEGSSFAY........................ISWKFE......................
NGLY1_RAT/489-553                ...qfhl------RYDIVRDRY.....IRVSD.....N.....NANISgwengVWK.....MESIFRKVE........KDWNMVYLAR.KEGSSFAY........................ISWKFE......................
H9GEH0_ANOCA/504-569             ..kllhl------TYNIVEDCY.....TRISNnnekiD.....GWEKG.....VWR.....MDSLSRKVE........SDWKMVYLAR.KEGTLSGY........................ISWKFE......................
F6WC45_MACMU/493-556             ...lhlc-------YNIVKDRY.....VRVSN.....N.....NQTISgwengVWK.....MESIFRKVE........TDWHMVYLAR.KEGSSFAY........................ISWKFE......................
Q9GYT7_CAEEL/312-375             .......KNYIKFTYDVINNVY.....SHNNA.....D.....GSDVS.....PRE.....LQYIERIVH........EGNNEAFIQP.DYPEEVNGg......................hIHWMF-r.....................
G5BF99_HETGA/491-553             ....ylc-------YNIVKDHY.....VRVSS.....N.....NQTISgwengVWK.....MESIFRKVE........TDWNMVYLAR.KEGSSFAY........................ISWKFE......................
H0YZA2_TAEGU/490-553             ...fhlv-------YNVIDDSY.....TRISN.....N.....NEKIS.....GWEagvlkAESIWRKVE........TDWKMVYLAR.KEGSSSAS........................ISWKFE......................
I0FTB6_MACMU/493-556             ...lhlc-------YNIVKDRY.....VRVSN.....N.....NQTISgwengVWK.....MESIFRKVE........TDWHMVYLAR.KEGSSFAY........................ISWKFE......................
H9F5X1_MACMU/491-554             ...lhlc-------YNIVKDRY.....VRVSN.....N.....NQTISgwengVWK.....MESIFRKVE........TDWHMVYLAR.KEGSSFAY........................ISWKFE......................
Q966B1_CAEEL/86-147              ......n-RYFEFKYEIVRGNY.....SHTNE.....D.....ELAVK.....PFI.....VRNIERHSD........GEPYDVYLHK.IKPDEEGM........................IYWKFN......................
PAWC1_CAEEL/244-305              .......ENYAKFTYNFINNLY.....SHTEP.....D.....GSPVR.....LFD.....FNGLERVED........YTENTVFLRR.KNPKEKGN........................IRWALN......................
F6WCT2_MACMU/474-537             ...lhlc-------YNIVKDRY.....VRVSN.....N.....NQTISgwengVWK.....MESIFRKVE........TDWHMVYLAR.KEGSSFAY........................ISWKFE......................
P91470_CAEEL/288-349             .......QNHVKFTYDIINNIY.....SHDNQ.....D.....GSPVN.....PKQ.....VFNIKRVVD........EENNEAYIGQ.EAPYRRSN........................IYWMFD......................
NGLY1_HUMAN/493-556              ...lhlc-------YNIVKDRY.....VRVSN.....N.....NQTISgwengVWK.....MESIFRKVE........TDWHMVYLAR.KEGSSFAY........................ISWKFE......................
O18169_CAEEL/60-121              .......ENYLKFTYNIIENTY.....SHKNR.....D.....GSLAE.....PCV.....ASAVERVVN........RKLNEAYLQK.IRGEDYGL........................IYWDFN......................
G5EFH6_CAEEL/81-142              ......h-RYFAFKYEIVRGKY.....SHTNK.....D.....GSAVK.....PFI.....VKNVERHSD........EEPYDVYLQK.KKRNEEGM........................IYWKFN......................
PAWC1_CAEEL/52-113               ......n-RYFEFKYEIERGKY.....SHTNE.....D.....ESAVK.....PFL.....VKNIERHAD........DDTYDVYLQK.IKPDEEGM........................IYWKFD......................
Q9N4T3_CAEEL/291-352             .......DNYVKFTYDIISNTY.....SHKRQ.....N.....GSSLE.....PYF.....VGNVKRVEN........RTLGVVYFEK.IDKTIIGT........................ILWEF-g.....................
O76682_CAEEL/460-523             .......KNYIKFTYDVINNVY.....SHNNV.....D.....GSDVS.....PRK.....LQYIERIVH........EGNNEAFIQP.DYPEEVNGg......................hIDWMFQ......................
H3DLD9_TETNG/476-539             ....lhv------RYSSVRDEY.....CRLSN.....N.....CEVIQ.....TWDrclwtKESVFRKVE........HDWEMVYLAR.TEGSAEGR........................ISWKFD......................
G3RSV6_GORGO/495-558             ...lhlc-------YNIVKDHY.....VRVSN.....N.....NQTISgwengVWK.....MESIFRKVE........TDWHMVYLAR.KEGSSFAY........................ISWKFE......................
G1T9A3_RABIT/452-515             ...lhlc-------YNIVKDSY.....VRVSN.....N.....NQTISgwengVWK.....MESIFRKVE........TDWNMVYLAR.KEGSPSAY........................ISWKFE......................
D2HUZ7_AILME/492-556             ..qfhlc-------YNIVKDGY.....VRVSN.....N.....NQTISgwengVWK.....MESIFRKVE........TDWNMVYLAR.REGSSYAY........................ISWKFE......................
Q1ZXR7_CAEEL/102-154             .......QDYIKFTYDIIKDTY.....SYDNV.....D.....GTPIS....cTYY.....PLN------........----------.--------........................------gyvesekeieslnmnfftsq..
G1QUM4_NOMLE/474-537             ...lhlc-------YDIVKDRY.....VRVSN.....N.....NQTISgwengVWK.....MESIFRKVE........TDWHMVYLAR.KEGSSFAY........................ISWKFE......................
O76676_CAEEL/328-391             .......QDYAKFTYDVISNTY.....SQSNE.....D.....GSPVK.....PYL.....ASNVEHVVD........RRLNVAYIHM.KEPINKRIg......................lINWEFD......................
P91472_CAEEL/499-561             .......ANYVKFWYNIVRNTY.....SQTHT.....N.....GSPVK.....PYL.....VANIERTID........TRLGEVFLHK.KERSEHWA.......................sIAWFFN......................
P91472_CAEEL/298-359             .......QNYVKFTYDIINNIY.....SHDNE.....D.....GSPVN.....PKQ.....VFNIKRVVD........EENNEAYIGQ.EALYRRSN........................MYWQFD......................
O76677_CAEEL/260-321             .......DNYVKFTYSILNNTY.....SHDNI.....D.....GSPVA.....PYF.....VDKIERLVD........RTNNEVYLRQ.EFPGVFSN........................MYWAFN......................
H2ZYD2_LATCH/467-531             ...vlhl------KYNTATDCY.....IRLSN.....D.....NEEIKgwekgVWK.....MESVFRKVE........NDWQMAYLAR.TEESSLGR........................ISWKFE......................
A3KQW7_DANRE/483-546             ...fhic-------YNVTKDCY.....YRVSN.....G.....QETIQgwqkgAWR.....TENMFRKEE........HDWQMVYLAR.TEGASFGR........................MSWKFN......................
O45155_CAEEL/648-709             .......ENHVKFTYDVMRDTY.....SHTQL.....N.....GSSYV.....PYN.....VANIERVVD........KRLNQVYLHR.NDSKKDTY........................LNWVFD......................
Q08B23_XENLA/474-538             ...rfhl------QYNVVEDTY.....TRTSN.....N.....NVVIAgwengAWK.....AESICRKVE........SDWKMVYLAR.TEGSSSAA........................ISWKIE......................
O76677_CAEEL/457-520             ......r-DYAKFTYDVISNTY.....SQSYE.....D.....GSPVK.....PYL.....ASNVEHVVD........RRLNVAYIHM.KEPINKRIg......................lINWEFD......................
G7NY95_MACFA/452-515             ...lhlc-------YNIVKDRY.....VRVSN.....N.....NQTISgwengVWK.....MESIFRKVE........TDWHMVYLAR.KEGSSFAY........................ISWKFE......................
F7D099_MONDO/492-555             ...fhiv-------YNPVEDYY.....VRISS.....NnetisGWLSG.....IWK.....MESIFRKVE........TDWNMVYLAR.KEGSPSAF........................ISWKFE......................
G3WDQ9_SARHA/458-523             ..klfhl------TYNPVDDCY.....VRVSS.....NndkisGWESG.....VWK.....MESVFRKVE........TDWKMVYLAR.KEGSSSGY........................ISWKFE......................
NGLY1_CHICK/488-553              ..klfhl------MYNVVEDSY.....TRISN.....N.....NEQITgwgtgIWK.....AESIARKVE........TDWKMVYLAR.KEGSSSAS........................ISWKFE......................
P91472_CAEEL/98-159              .......QNSVKFTYDIIKNTY.....SHDND.....D.....GSQVR.....PYV.....ASNIERVVD........KENNETYLHP.EYPLEIAH........................IHWVFN......................
F7DQ31_MONDO/476-539             ...fhiv-------YNPVEDYY.....VRISS.....NnetisGWLSG.....IWK.....MESIFRKVE........TDWNMVYLAR.KEGSPSAF........................ISWKFE......................
O76682_CAEEL/673-734             .......ENHVKFTYDVTSDTY.....SHTKP.....N.....GSSYV.....PYN.....VGNIERVVD........KRLNQVYLHR.NDSTKYTY........................ISWAFD......................
G1NF31_MELGA/451-514             ...fhli-------YNVVEDSY.....TRISN.....N.....NEKITgwgtgVWK.....AESIWRKVE........TDWKMVYLAR.KEGSSSAS........................ISWKFE......................
O45155_CAEEL/464-519             .......QNYIKFTYDVINNVY.....SHKNE.....D.....GSDIL.....PTD.....IHWVF----........----------.--------........................------klknngksvkkvvikmegiddi
H2VWB9_CAEJA/21-82               ......a-DHLEFSYNIVTDTY.....SQEPA.....K.....GFVSA.....TFE.....CENIKRVEE........NDWKFVYLCR.KDGAKEGN........................ISWHFD......................
H3DWH0_PRIPA/17-75               .....vv-------YDVVKDEY.....SIGGEi...rC.....GFAGS.....LAA.....GSGIQRKVE........QDWRMVYVCR.EEGAAEGL........................LEWNV-e.....................
G3TBR2_LOXAF/495-559             ..qfhlg-------YNTVKDHY.....VRVSD.....N.....NQTISgwengVWK.....MESIFRKVE........TDWNMVYLAR.MEGSSSAY........................ISWKFE......................
O76682_CAEEL/107-175             ......a-DYATFEYNVTSDEY.....SRLND.....D.....GTKIQ.....PWI.....VKNMERKVKfyf.fkgfPVEKTTFIHK.ITPNEDGL........................IYWKFE......................
O18173_CAEEL/253-314             .......ENILDFEYDIVKDKY.....SQSPE.....N.....GLFSQ.....VYD.....VKNIRRIRD........TNTNEVYFGL.VDGADHGT........................ISWRFD......................
P91470_CAEEL/81-142              .......QNSVKFTYDIIKNTY.....SHDND.....D.....GSQFR.....PFV.....ASNIERVVD........KENNETYLYP.EYPLEFAH........................IHWVFN......................
G1NW75_MYOLU/453-516             ...lhlc-------YNIVKDHY.....VRVSN.....N.....NQTISgwengVWK.....MESIFRKVE........TDWNMVYLAR.KEGSSHAH........................ISWKFE......................
F6PR92_CALJA/452-513             .....lc-------YNIVKDRY.....VRVSN.....N.....NQTISgwengVWK.....MESIFRKVE........TDWHMVYLAR.KEGSSFAY........................ISWKFE......................
O18170_CAEEL/85-135              .......EEYIKFTYDVINDVY.....SHSPK.....K.....GFMAQ.....AYY.....MENMKRCEE........PDHI------.--------........................------miswhfdlk.............
NGLY1_DANRE/483-546              ...fhic-------YNVTKDCY.....YRVSN.....G.....QETIQgwqkgAWR.....TENMFRKEE........HDWQMVYLAR.TEGASFGR........................MSWKFN......................
E3NHL0_CAERE/215-276             .......ENCFEFSYDVNRDVY.....SQSPA.....A.....GFISQ.....AFE.....CDNLKRVVE........TDWNFVYLCR.QDGKKEGN........................ISWHFD......................
NGLY1_MOUSE/489-553              ...qfhl------RYDIVRDRY.....IRVSD.....N.....NINISgwengVWK.....MESIFRKVE........KDWNMVYLAR.KEGSSFAY........................ISWKFE......................
#=GR NGLY1_MOUSE/489-553   SS    ...EEEE------EEETTTTEE.....EECCG.....T.....TEEEESGGGG-SS.....EESEEEEEE........TTTTEEEEEE.-TT-SEEE........................EEEEEE......................
O76676_CAEEL/123-184             .......HNYVKFTYDILNNTY.....SHDNI.....D.....GSPVA.....PYF.....VDKIERVVD........RKNNEAYLHQ.EFPDDFSN........................MYWAF-s.....................
F7FGS1_ORNAN/453-517             ...llhl------SYNAVKDSY.....TRISN.....NneeiiGWEKG.....VWK.....MDSLFRKVE........RDWNMVYLAR.KEGSSSAH........................VSWKFE......................
O18170_CAEEL/245-306             .......EEYSKFTYDIINDVY.....SHSPK.....E.....GFMSQ.....AYY.....MDNIQRCEE........PDHITVHLCK.IFMEKTAT........................ISWHFD......................
H0WKM6_OTOGA/494-557             ...lhlc-------YNIVKDHY.....VRVSN.....N.....NQTISgwengVWK.....MESIFRKIE........TDWNMVYLAR.KEGSSFAY........................ISWKFE......................
H2SWE9_TAKRU/473-539             .drflhv------RYSSVKDEY.....CRVSN.....N.....SEVIQ.....TWDrclwkKESVFRKIE........HDWEMVYIAR.TEGSSEGR........................ISWKFD......................
F6VBL0_HORSE/416-479             ...lhlc-------YNIVKDQY.....VRVSN.....N.....NQTISgwesgVWK.....MESIFRKVE........TDWNMVYLAR.KEGSSYAY........................ISWKFE......................
O45199_CAEEL/157-204             ......s-NYVEFTYDVVTDTY.....SQHPK.....H.....GFLAQ.....AFK.....VKNVQRVEK........HEMGGYFF--.--------........................------gy....................
H2PBB4_PONAB/476-539             ...lhlc-------YNIVKDCY.....VRVSN.....N.....NETISgwengVWK.....MESIFRKVE........TDWHMVYLAR.KEGSSFAY........................ISWKFE......................
Q966B1_CAEEL/269-330             .......ENYAKFTYNFLNNSY.....SHNEP.....D.....GSPVR.....LFD.....FNGLERVED........YTENTVFLRR.KNPKEKGN........................IKWALD......................
F1LLZ5_RAT/455-519               ...qfhl------RYDIVRDRY.....IRVSD.....N.....NANISgwengVWK.....MESIFRKVE........KDWNMVYLAR.KEGSSFAY........................ISWKFE......................
P91459_CAEEL/101-131             ......h---------------.....-----.....-.....-----.....---.....--NVERHSE........KQ-YAVYLQK.KDKNEEGS........................IYWKFN......................
Q9N4T3_CAEEL/113-175             .......ENYAKFTYDIISNTY.....SYKRH.....G.....GSSFE.....PYS.....VFNVQRVEN........RTLGAVYFKIlIKGLLELW........................LEWKFD......................
F1RS44_PIG/477-540               ...lhlc-------YNTVKNHY.....VRVSSnnrilD.....GWENG.....VWK.....MESIFRKVE........TDWNMVYLAR.KEGSSYAY........................ISWKFE......................
Q9GYT3_CAEEL/84-144              ......d-KYVEFRYDPISGKY.....SHVNN.....D.....GSRIN.....PFV.....VKNVERHSE........KQ-YAVYLHK.KDSNEEGS........................IYWKFN......................
H2QM74_PANTR/493-556             ...lhlc-------YNIVKDRY.....VRVSN.....N.....NQTISgwengVWK.....MESIFRKVE........TDWHMVYLAR.KEGSSFAY........................ISWKFE......................
Q9GYU0_CAEEL/326-389             .......KDYAKFTYDIISNTY.....SQNFE.....D.....GSPVK.....PYL.....ASNAERVVD........RRSNVAYIHM.KEPINKRIg......................fINWEFD......................
Q9GYT7_CAEEL/107-199             .......TEYATFEYNVTSDEY.....SRLNN.....D.....GTKIQ.....PWL.....VKNMERKVKfyy.fkgfPVRKTEFIHK.IKPNEDGLncsdipkddelmilnpkfktffigIYWNIN......................
O76677_CAEEL/84-144              ......n-RYVEFQYDPISGKY.....SHVNK.....N.....GSRIN.....PFV.....VKNVERHSE........KP-YDAYLHK.KDKNEEGS........................IYWKFN......................
B4MYN5_DROWI/514-555             .ktwqsa---------------.....-----.....-.....-----.....QFS.....SKNINRKVE........RDWKMAYLAR.LEDTDSAE........................ITWKFD......................
G3QJW4_GORGO/494-557             ...lhlc-------YNIVKDHY.....VRVSN.....N.....NQTISgwengVWK.....MESIFRKVE........TDWHMVYLAR.KEGSSFAY........................ISWKFE......................
F1NWD4_CHICK/488-553             ..klfhl------MYNVVEDSY.....TRISN.....N.....NEQITgwgtgIWK.....AESIARKVE........TDWKMVYLAR.KEGSSSAS........................ISWKFE......................
F7FGJ8_ORNAN/448-512             ...llhl------SYNAVKDSY.....TRISN.....NneeiiGWEKG.....VWK.....MDSLFRKVE........RDWNMVYLAR.KEGSSSAH........................VSWKFE......................
Q9GYT7_CAEEL/521-582             .......ENHVKFTYDVMRDMY.....SHTKP.....N.....GSSYV.....PYN.....VENIERVVD........KRLNQVYLHR.NDLTKYTY........................ISWVFD......................
H2ZBE2_CIOSA/96-159              ....ihi------EYSCSSDKYtrisdSKTSH.....G.....GWKTF.....VFR.....VQDVMRKVE........YDWKRAYLCR.KEKSLMGY........................IAWQIE......................
G0NIJ2_CAEBE/445-506             .......ENYAEFSYDIIRNIY.....STSTE.....K.....GFISQ.....AFE.....CKNIQRKEE........LDWKQVYLCR.ENGKESGE........................ISWHIN......................
Q4RIW3_TETNG/472-535             ....lhv------RYSSVRDEY.....CRLSN.....N.....CEVIQ.....TWDrclwtKESVFRKVE........HDWEMVYLAR.TEGSAEGR........................ISWKFD......................
G7MJY5_MACMU/452-515             ...lhlc-------YNIVKDRY.....VRVSN.....N.....NQTISgwengVWK.....MESIFRKVE........TDWHMVYLAR.KEGSSFAY........................ISWKFE......................
Q7QJB1_ANOGA/546-594             ..erite---------------.....---KS.....N.....GWESR.....QYV.....SRNIFRKEE........LDWKMVYLAR.TEGTDEAT........................IEWNFD......................
C0PUG1_SALSA/191-254             ....fhl------RYNSTKDHY.....CRVSN.....D.....SEDIQ.....GWD.....-KTVWRKESvfr..kleSDWQMVYLAR.TEGSSSGK........................ISWKLD......................
F7AI61_CALJA/496-557             .....lc-------YNIVKDRY.....VRVSN.....N.....NQTISgwengVWK.....MESIFRKVE........TDWHMVYLAR.KEGSSFAY........................ISWKFE......................
#=GC SS_cons                     ...EEEE------EEETTTTEE.....EECCG.....T.....TEEEESGGGG-SS.....EESEEEEEE........TTTTEEEEEE.-TT-SEEE........................EEEEEE......................
#=GC seq_cons                    ......h.......YsllcDpY.....s+sss.....s.....spslp.....sac.....hcsIhRKVE........pDWphVYLsR.cEuss.uh........................ISWKF-......................
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