GenomeNet

Database: Pfam
Entry: Daxx
LinkDB: Daxx
Original site: Daxx 
#=GF ID   Daxx
#=GF AC   PF03344.13
#=GF DE   Daxx N-terminal Rassf1C-interacting domain
#=GF AU   Finn RD
#=GF SE   Pfam-B_3933 (release 6.5)
#=GF GA   27.60 27.60;
#=GF TC   28.60 27.60;
#=GF NC   27.30 25.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   11225842
#=GF RT   The Daxx enigma. 
#=GF RA   Michaelson JS; 
#=GF RL   Apoptosis 2000;5:217-220.
#=GF RN   [2]
#=GF RM   21134643
#=GF RT   Structural characterization of the DAXX N-terminal helical
#=GF RT   bundle domain and its  complex with Rassf1C.
#=GF RA   Escobar-Cabrera E, Lau DK, Giovinazzi S, Ishov AM, McIntosh LP;
#=GF RL   Structure. 2010;18:1642-1653.
#=GF DR   INTERPRO; IPR031333;
#=GF CC   The Daxx protein (also known as the Fas-binding protein) is
#=GF CC   thought to play a role in apoptosis. Daxx forms a complex with
#=GF CC   Axin [1]. Remodelling of the family to a short domain based on
#=GF CC   the PDB:2kzs structure gives a more representative family. DAXX
#=GF CC   is a scaffold protein shown to play diverse roles in
#=GF CC   transcription and cell cycle regulation. This N-terminal domain
#=GF CC   folds into a left-handed four-helix bundle (H1, H2, H4, H5) that
#=GF CC   binds to the N-terminal residues of the tumour-suppressor
#=GF CC   Rassf1C [2].
#=GF SQ   72
#=GS G3UWJ9_MOUSE/54-137       AC G3UWJ9.1
#=GS H2S992_TAKRU/1-95         AC H2S992.1
#=GS M3XTH8_MUSPF/87-185       AC M3XTH8.1
#=GS Q5STR5_HUMAN/48-130       AC Q5STR5.7
#=GS H0V8K1_CAVPO/40-138       AC H0V8K1.1
#=GS F6UBT9_HORSE/80-139       AC F6UBT9.1
#=GS F6RWB7_XENTR/37-135       AC F6RWB7.1
#=GS Q1LUU4_DANRE/53-151       AC Q1LUU4.1
#=GS G7P2T1_MACFA/138-236      AC G7P2T1.1
#=GS E7F336_DANRE/53-151       AC E7F336.2
#=GS G3SCB0_GORGO/48-146       AC G3SCB0.1
#=GS DAXX_CANLF/48-146         AC Q5TJE1.1
#=GS A0A0U1RRR8_RAT/48-104     AC A0A0U1RRR8.1
#=GS G3UX50_MOUSE/54-152       AC G3UX50.1
#=GS F1PRZ2_CANLF/48-146       AC F1PRZ2.1
#=GS F1MGU0_BOVIN/48-146       AC F1MGU0.1
#=GS C3ZPA3_BRAFL/1-78         AC C3ZPA3.1
#=GS A0A096M742_POEFO/50-148   AC A0A096M742.1
#=GS F1QQQ8_DANRE/53-151       AC F1QQQ8.1
#=GS H2S991_TAKRU/57-155       AC H2S991.1
#=GS F6XJZ1_MONDO/49-147       AC F6XJZ1.1
#=GS M4AQX5_XIPMA/57-155       AC M4AQX5.1
#=GS H2PL61_PONAB/48-146       AC H2PL61.1
#=GS M7BED8_CHEMY/241-311      AC M7BED8.1
#=GS Q6MGC8_RAT/48-146         AC Q6MGC8.1
#=GS H2QST5_PANTR/48-146       AC H2QST5.1
#=GS H0WNX9_OTOGA/48-146       AC H0WNX9.1
#=GS H2KVJ0_CLOSI/23-114       AC H2KVJ0.1
#=GS DAXX_RAT/48-146           AC Q8VIB2.1
#=GS DAXX_MOUSE/54-152         AC O35613.1
#=GS A0A091CXY6_FUKDA/49-147   AC A0A091CXY6.1
#=GS Q4VX54_HUMAN/48-146       AC Q4VX54.1
#=GS G3NAQ4_GASAC/61-159       AC G3NAQ4.1
#=GS H2YCA2_CIOSA/71-164       AC H2YCA2.1
#=GS W5L425_ASTMX/45-143       AC W5L425.1
#=GS W5PIE8_SHEEP/60-158       AC W5PIE8.1
#=GS G3UWI4_MOUSE/54-152       AC G3UWI4.7
#=GS G1P9K4_MYOLU/60-158       AC G1P9K4.1
#=GS G5BB44_HETGA/49-147       AC G5BB44.1
#=GS L5KYS5_PTEAL/45-143       AC L5KYS5.1
#=GS H2ZUZ5_LATCH/50-148       AC H2ZUZ5.1
#=GS G3QUQ4_GORGO/48-146       AC G3QUQ4.1
#=GS A0A096NHI2_PAPAN/48-146   AC A0A096NHI2.1
#=GS V8N3R3_OPHHA/16-96        AC V8N3R3.1
#=GS DAXX_HUMAN/48-146         AC Q9UER7.2
#=GS DAXX_HUMAN/48-146         DR PDB; 2KZS A; 55-144;
#=GS DAXX_HUMAN/48-146         DR PDB; 2KZU A; 55-144;
#=GS M3W1E7_FELCA/48-146       AC M3W1E7.1
#=GS A0A0D9RB39_CHLSB/48-146   AC A0A0D9RB39.1
#=GS A0A0P7TIG3_9TELE/1-93     AC A0A0P7TIG3.1
#=GS G3VZK4_SARHA/59-157       AC G3VZK4.1
#=GS G1SZK9_RABIT/48-146       AC G1SZK9.2
#=GS F1RZS8_PIG/60-158         AC F1RZS8.2
#=GS Q8UUL3_ORYLA/38-133       AC Q8UUL3.4
#=GS H0Y2H4_OTOGA/48-146       AC H0Y2H4.1
#=GS H3CIB9_TETNG/57-155       AC H3CIB9.1
#=GS H0XHD9_OTOGA/48-141       AC H0XHD9.1
#=GS I3JNW9_ORENI/58-156       AC I3JNW9.1
#=GS Q3UKR0_MOUSE/54-152       AC Q3UKR0.1
#=GS A0A087X7H1_POEFO/57-155   AC A0A087X7H1.2
#=GS G3HQ34_CRIGR/48-146       AC G3HQ34.1
#=GS G3NAR1_GASAC/40-136       AC G3NAR1.1
#=GS A0A088A2C7_APIME/105-201  AC A0A088A2C7.1
#=GS I3JNW8_ORENI/60-132       AC I3JNW8.1
#=GS L9L783_TUPCH/48-146       AC L9L783.1
#=GS G3TYA4_LOXAF/48-146       AC G3TYA4.1
#=GS G1L3X7_AILME/60-158       AC G1L3X7.1
#=GS S9XF62_9CETA/43-101       AC S9XF62.1
#=GS S9X7D4_9CETA/132-237      AC S9X7D4.1
#=GS F6ZLZ0_MACMU/25-123       AC F6ZLZ0.1
#=GS I3M0F4_ICTTR/48-146       AC I3M0F4.1
#=GS L5LIH5_MYODS/48-146       AC L5LIH5.1
#=GS G3I6W2_CRIGR/48-146       AC G3I6W2.1
#=GS H3DLF3_TETNG/56-154       AC H3DLF3.1
G3UWJ9_MOUSE/54-137                  .....................g-GSSNSGSRKCYKLDNEKLFEEFLELCKT..ETSDHP.......EVVPFLHKLQQRAQSVFLASAEF..CNILSRVLARSRKR.PAKIYVYINELC---------------........
H2S992_TAKRU/1-95                    .....................n-----KKEAHVLQAENQRLFAEFVAHCSA..DTMDCP.......EVLAYLETRHSKASPEYLSSVEF..RNTLGHCLTRAQAH.RSKTFVYINELCTVLKQHAAKKRQST-s.......
M3XTH8_MUSPF/87-185                  .....................g-GSSSSGGKKCYKLENEKLFEEFLELCKT..QTADHP.......EVVPFLYSRQQRAHSLFLASAEF..CNILSRVLSRAQSR.PAKLYVYINELCTVLKAHSAKKKLNL-a.......
Q5STR5_HUMAN/48-130                  ....................rg--SSSSGGKKCYKLENEKLFEEFLELCKM..QTADHP.......EVVPFLYNRQQRAHSLFLASAEF..CNILSRVLSRARSR.PAKLYVYINEL----------------........
H0V8K1_CAVPO/40-138                  ....................ll--SEPLGWRRNATVENEKLFEEFFELCKM..QTSDHP.......EVVPFLSKLQQRAHPVFLASVEF..CNILSRVLSRARGR.PSKLYVYINELCTVLKAHSAKKKLNL-a.......
F6UBT9_HORSE/80-139                  yltlmmgkshrngphllldsvs-----------------------------..------.......-----------------------..---LAQNLGRSSHR.PAKLYVYINELCTVLKAHSAKKKVNL-a.......
F6RWB7_XENTR/37-135                  ...................kgr---ESKRKSGSMSAENTALFEKFVDYCTR..LTQEHP.......EVIVFLRGRLSKASPSFLSSVEF..HNILGRCLTRVQSK.HTKVYVYINELCTALKANTTKRKIIL-k.......
Q1LUU4_DANRE/53-151                  .....................p-FASAKKDTHVLKVENEKLFNEFVEHCSK..HSQEHP.......EVMTYLQTRYSKALPTFLTSVEF..RNTLGRCLTRAQAN.AGKTFVYINELCTVLKQHTPRKRSSI-q.......
G7P2T1_MACFA/138-236                 ....................rg--SSSSGGKKCYKLENEKLFQEFLELCKT..QTADHP.......EVVPFLSNRQQRAHSLFLASAEF..CNILSRVLSRAQSR.PSKLYVYINELCTVLKAHSAKKKLNL-a.......
E7F336_DANRE/53-151                  .....................p-FASAKKDTHVLKVENEKLFNEFVEHCSK..HSQEHP.......EVMTYLQTRYSKALPTFLTSVEF..RNTLGRCLTRAQAN.AGKTFVYINELCTVLKQHTPRKRSSI-q.......
G3SCB0_GORGO/48-146                  ....................rg--SSSSGGKKCYKLENEKLFEEFLELCKM..QTADHP.......EVVPFLYSRQQRAHSLFLASAEF..CNILSRVLSRARSR.PAKLYVYINELCTVLKAHSAKKKLNL-a.......
DAXX_CANLF/48-146                    .....................g-GSSSSGGKKCYKLENEKLFEEFLELCKM..QTADHP.......EVVPFLYNRQQRAHSLFLASAEF..CNILSRVLSRAQSR.PAKLYVYINELCTVLKAHSAKKKLNL-a.......
A0A0U1RRR8_RAT/48-104                .....................g-GSSNSGSRKCYKLENEKLFEEFLELCKM..QTSDHP.......EVVPFLHKLQQRAQSAFLASAE-..--------------.---------------------------........
G3UX50_MOUSE/54-152                  .....................g-GSSNSGSRKCYKLDNEKLFEEFLELCKT..ETSDHP.......EVVPFLHKLQQRAQSVFLASAEF..CNILSRVLARSRKR.PAKIYVYINELCTVLKAHSIKKKLNL-a.......
F1PRZ2_CANLF/48-146                  .....................g-GSSSSGGKKCYKLENEKLFEEFLELCKM..QTADHP.......EVVPFLYNRQQRAHSLFLASAEF..CNILSRVLSRAQSR.PAKLYVYINELCTVLKAHSAKKKLNL-a.......
F1MGU0_BOVIN/48-146                  .....................g-GSSSSGGKKCYKLENEKLFEEFLALCKT..QTADHP.......EVVPFLYNRQQRAHPLFLASAEF..CNILSRVLSRAQNR.PAKLYVYINELCTVLKAHSAKKKLNL-a.......
C3ZPA3_BRAFL/1-78                    .....................q----------------------FVHLCST..LTKDK-.......DVLKFLQKRFNAADPMYLSSQAF..LDFLTKRTEKLKESgKKEVFVHMKAVIDELKANK--------ksesgsek
A0A096M742_POEFO/50-148              .....................p-FSSAKKIAKALQVENQKLFDEFVQHCTP..HTNDCP.......EVLTFLQTKHSKACPDYLCSVEF..RNALGQCLTQAQGN.VGKTFVYINELCTVLKQHSVKKRQTL-s.......
F1QQQ8_DANRE/53-151                  .....................p-FASAKKDTHVLKVENEKLFNEFVEHCSK..HSQEHP.......EVMTYLQTRYSKALPTFLTSVEF..RNTLGRCLTRAQAN.AGKTFVYINELCTVLKQHTPRKRSSI-q.......
H2S991_TAKRU/57-155                  .....................p-FASNKKEAHVLQAENQRLFAEFVAHCSA..DTMDCP.......EVLAYLETRHSKASPEYLSSVEF..RNTLGHCLTRAQAH.RSKTFVYINELCTVLKQHAAKKRQST-s.......
F6XJZ1_MONDO/49-147                  .....................g-SSSSGGSKKCYQLENEKLFEEFVDLCKK..QTGEHP.......EVVPFLCNKRQRARPTFLASAEL..RNVLSRVLSRAQAR.PTKLYVYINELCTLLKAHSTKRKVPL-t.......
M4AQX5_XIPMA/57-155                  .....................p-FSSAKKSTKALQVQNQKLFDEFVQHCTP..LTNECP.......EVLTFLQTKHSKACPDYLCSVEF..RNSLGQCLTRAQGN.VGKTFVYINELCTMLKQHSVKKRQTL-s.......
H2PL61_PONAB/48-146                  ....................rg--SSSSGGKKCYKLENEKLFEEFLELCKM..QTADHP.......EVVPFLSNRQQRAHSLFLASAEF..CNILSRVLSRARSR.PAKLYVYINELCTVLKAHSAKKKLNL-a.......
M7BED8_CHEMY/241-311                 .................aqhgg----------SFKAENEQLFGEFLECCSR..LTEEHP.......EVIPFLASRHQKASTEFLASAEF..RNVLGRCLTRVQTP.A--------------------------rkd.....
Q6MGC8_RAT/48-146                    .....................g-GSSNSGSRKCYKLENEKLFEEFLELCKM..QTSDHP.......EVVPFLHKLQQRAQSAFLASAEF..RNILSRVLSRSRNR.PAKLYVYINELCTVLKAHSIKKKLNL-a.......
H2QST5_PANTR/48-146                  ....................rg--SSSSGGKKCYKLENEKLFEEFLELCKM..QTADHP.......EVVPFLYNRQQRAHSLFLASAEF..CNILSRVLSRARSR.PAKLYVYINELCTVLKAHSAKKKLNL-a.......
H0WNX9_OTOGA/48-146                  .....................g-ASSTSGSKKCYKLENEKLFEEFLELCKM..PTADHP.......EVVPFLHSRKQRAHSLFLASAEF..CNILSRVLSRARSQ.PAKLYVYINELCTVLKAHSAKKKLNL-a.......
H2KVJ0_CLOSI/23-114                  ..........kspreihiigki-----------------KQFEESLQKY--..LPKSDR.......EVISVLRRKYQRTNTEFRHSKQC..KSVLRQCLQRIAAR.PTRVYMILNDLKTTLKLQT--------tgislnis
DAXX_RAT/48-146                      .....................g-GSSNSGSRKCYKLENEKLFEEFLELCKM..QTSDHP.......EVVPFLHKLQQRAQSAFLASAEF..RNILSRVLSRSRNR.PAKLYVYINELCTVLKAHSIKKKLNL-a.......
DAXX_MOUSE/54-152                    .....................g-GSSNSGSRKCYKLDNEKLFEEFLELCKT..ETSDHP.......EVVPFLHKLQQRAQSVFLASAEF..CNILSRVLARSRKR.PAKIYVYINELCTVLKAHSIKKKLNL-a.......
A0A091CXY6_FUKDA/49-147              ....................gg--STSSGGKKCYKLENEKLFEEFLELCKM..QTSDHP.......EVVPFLCKLQQRAHPLFLASAEF..CNILSRVLSRARSR.PSKLYVYINELCTVLKAHSAKKKLNV-a.......
Q4VX54_HUMAN/48-146                  ....................rg--SSSSGGKKCYKLENEKLFEEFLELCKM..QTADHP.......EVVPFLYNRQQRAHSLFLASAEF..CNILSRVLSRARSR.PAKLYVYINELCTVLKAHSAKKKLNL-a.......
G3NAQ4_GASAC/61-159                  .....................p-FASAKKDKHVLQAENQRLFTEFVEHCSS..LTQSCP.......EVLTFLQTKHAKASPEYLSSVEF..RNTLGRCLTRTQAN.RSKAFVYINELCTALRQHAVKRRQTL-t.......
H2YCA2_CIOSA/71-164                  ..............eqgdrsks----------------IKLLEEFIGLCMLliKKENRP......iEIVQFLRRRYSKATSDYKNSEEF..CAVVERYIADLRRG.VKREFVYINDLATHLNKHAIKQ-----ikrpt...
W5L425_ASTMX/45-143                  .....................p-FSTAKKEGHVLKVENEKLFGEFLEHCMA..HTKEHP.......EVVTFLQTKYSKASPDFLMSVEF..RNALGRCLTRAQAS.TTKTFVYINELCTLLKQHSAKRRALI-q.......
W5PIE8_SHEEP/60-158                  .....................g-GSSSSGGKKCYKLENEKLFEEVLALCKT..QTADHP.......EVVPFLYNRQQRAHPLFLASAEF..CNILSRVLSRAQNR.PAKLYVYINELCTVLKAHSAKKKLNL-a.......
G3UWI4_MOUSE/54-152                  .....................g-GSSNSGSRKCYKLDNEKLFEEFLELCKT..ETSDHP.......EVVPFLHKLQQRAQSVFLASAEF..CNILSRVLARSRKR.PAKIYVYINELCTVLKAHSIKKKLNL-a.......
G1P9K4_MYOLU/60-158                  ..................ggng----SSGGKKCYKLENEKLFEEFLELCKA..QTEDHP.......DVVPFLCKRQQRAHALFLASAEF..CNILSRVLSRAQSR.PAKLYVYINELCTVLKAHSAKKKMNI-a.......
G5BB44_HETGA/49-147                  .....................g-GSSSSGGKKCYKLENEKLFEEFLELCKM..QTSDHP.......EVVPFLCKLQQRAHSVFLASAEF..CNILSRVLSRARSR.PSKLYVYINELCTVLKAHSAKKKLN--pa......
L5KYS5_PTEAL/45-143                  ................phgaeg------SGKKCYKLENEKLFEEFLELCKA..HTADHP.......DVVPFLYKRQQRAHSLFLASAEF..CNILSRVLSRAQSR.PAKLYVYINELCTVLKAHSAKKKLNL-a.......
H2ZUZ5_LATCH/50-148                  .....................k-SSEKDAEKVILKAQNEKLFAEFVEFCSK..LSDGHP.......EVISFLKGRHEKARPEYLASTEF..RNVIGRCLTRVQNK.KGKVFVYINEVCTALKANSQKKKVPI-l.......
G3QUQ4_GORGO/48-146                  ....................rg--SSSSGGKKCYKLENEKLFEEFLELCKM..QTADHP.......EVVPFLYSRQQRAHSLFLASAEF..CNILSRVLSRARSR.PAKLYVYINELCTVLKAHSAKKKLNL-a.......
A0A096NHI2_PAPAN/48-146              ....................rg--SSSSGGKKCYKLENEKLFQEFLELCKT..QTADHP.......EVVPFLSNRQQRAHSLFLASAEF..CNILSRVLSRAQSR.PSKLYVYINELCTVLKAHSAKKKLNL-a.......
V8N3R3_OPHHA/16-96                   ..................pfpl---------------------QFVAFCSR..HTEDHP.......EVISYLSGRHQKTSPEYLASVEF..RNVLSRCLTRVQAR.SGKTYVYINELCTTFRAHSQRKRA---ap......
DAXX_HUMAN/48-146                    ....................rg--SSSSGGKKCYKLENEKLFEEFLELCKM..QTADHP.......EVVPFLYNRQQRAHSLFLASAEF..CNILSRVLSRARSR.PAKLYVYINELCTVLKAHSAKKKLNL-a.......
#=GR DAXX_HUMAN/48-146         SS    ....................XX--XXXXXSS---HHHHHHHHHHHHHHHHH..HTTT-T.......THHHHHHHHHHTC-CCHHCSHHH..HHHHHHHHHHHHH-.CCCHHHHHHHHHHHHHHCCSSTT--X-X.......
M3W1E7_FELCA/48-146                  .....................g-GSSSSGGKKCYKLENEKLFEEFLELCKT..QTADHP.......EVVPFLYNRQQRAHSLFLASAEF..CNILSRVLSRAQSR.PAKLYVYINELCTVLKAHSAKKKLNL-a.......
A0A0D9RB39_CHLSB/48-146              ....................rg--SSSSGGKKCYKLENEKLFQEFLELCKT..QTADHP.......EVVPFLCNRQQRAHSLFLASAEF..CNILSRVLSRAQSR.PFKLYVYINELCTVLKAHSAKKKLNL-a.......
A0A0P7TIG3_9TELE/1-93                .....................k-------ECHVLLLENQKLFKEFVDHCSA..HTKEHP.......EVITYLQSKHAKASPTFLSSVEL..RNTLGRCLTQAQAY.SSKTFVYINELCTVLKQHAVKKRIS--at......
G3VZK4_SARHA/59-157                  .....................g-SSSSGGSKKCYQLENEKLFEEFLDLCKK..QTGEHP.......EVVPFLCNRRQRARPTFLASAEL..RNVLSRVLSRAQSR.PTKLYVYINELCTLLKAHSIKRKVPL-t.......
G1SZK9_RABIT/48-146                  .....................g-GSSSSGGKKCYKLENEKLFEEFLELCKT..QTADHP.......EVVPFLSSRQQRAHSVFLASAEF..CNILSRVLSRARSR.PAKLYVYINELCTVLKAHSAKKKLNF-a.......
F1RZS8_PIG/60-158                    ...................ggg---SSSGGKKCYKLENEKLFKEFLELCRR..QTADHP.......EVVPFLSSRQQRAHSLFLASAEF..HNILSRVLSRAQSR.PAKLYVYINELCTVLKANSAKKKMNL-a.......
Q8UUL3_ORYLA/38-133                  .............kgqhlvagl------------LAENQKLFSEFVEHCSA..QTKECP.......EVLEYLQLKHSKTCPEFLSSVEF..RNTLKGCLTRAQNN.RSKTFVFINELCTVLKQHRDKRRLTL-s.......
H0Y2H4_OTOGA/48-146                  .....................g-ASSTSGGRKCYKLENEKLFEEFLELCKM..RTADHP.......EMVPFLRSRKQWAHSLFLASAEF..FNVLSRVLSLARSQ.PAKLYVYINELCTVLKAHSAKKKLHL-a.......
H3CIB9_TETNG/57-155                  .....................p-CVSARREPHVLQAENERLFGEFVDHCLA..DTTDCP.......EVLDYLKTRHAKASPEYLCSVEF..RNTLGHCLSRAQAH.RSKTFVYINELCTVLTQHAAKKRQVT-t.......
H0XHD9_OTOGA/48-141                  .....................g-ASSTSGSKKCYKLENEKLFEEFLDLCKK..PTADYP.......EVVPFLHSR-QRAHSLFLASAEF..CNFLSWVLSLARSQ.P----VYINELCTVLKAHSAKKKLNL-t.......
I3JNW9_ORENI/58-156                  .....................p-FATAKKTTQCLQAENQKLFTEFVEHCRP..LTEDCP.......EVLTFLQTKHSKACPDFLSSVEL..RNTLGRCLTRAQAN.RSKTFVYINELCTVLKQHAIKKRQTL-s.......
Q3UKR0_MOUSE/54-152                  .....................g-GSSNSGSRKCYKLDNEKLFEEFLELCKT..ETSDHP.......EVVPFLHKLQQRAQSVFLASAEF..CNILSRVLARSRKR.PAKIYVYINELCTVLKAHSIKKKLNL-a.......
A0A087X7H1_POEFO/57-155              .....................p-FSSAKKIAKALQVENQKLFDEFVQHCTP..HTNDCP.......EVLTFLQTKHSKACPDYLCSVEF..RNALGQCLTQAQGN.VGKTFVYINELCTVLKQHSVKKRQTL-s.......
G3HQ34_CRIGR/48-146                  ....................gg--SHNSGGRKCYKLENERLFEEFLELCKV..QTSDHP.......EVVPFLHKQQQRTQSLFLASAEF..CNIMPRVLSRARNR.PAKLYVYINELCTVLKAHSSKKKQNL-a.......
G3NAR1_GASAC/40-136                  ..............praqqpaa----------THIAENQRLFTEFVEHCSS..LTQSCP.......EVLTFLQTKHAKASPEYLSSVEF..RNTLGRCLTRTQAN.RSKAFVYINELCTALRQHAVKRRQTL-t.......
A0A088A2C7_APIME/105-201             ...................lvv------KEKKIISSVEQDVFPMFISLCLQrdRSEDMK.......TIVNKLKRRYEQLDPKYANSKAF..INFLNDKRNDIMNS.DSKLFVYIAEVMNEMKNS-Y-------kgkssll.
I3JNW8_ORENI/60-132                  .....................p-FATAKKTTQCLQAENQKLFTEFVEHCRP..LTEDCP.......EVLTFLQTKHSKACPDFLSSHAIkkRQTLSKV-------.---------------------------dpgpst..
L9L783_TUPCH/48-146                  .....................g-GSSSSGGKKCYKLENEKLFKEFLELCKT..QTADHP.......EVVPFLYNRQQRAHPLFLASAEF..CNILSRVLSRARSR.PAKLYVYINELCTVLKAHSAKKKLNL-a.......
G3TYA4_LOXAF/48-146                  ....................eg--SSSSGSKKCYKLENEKLFEEFLKLCKM..QTAEHP.......EVVPFLYNRQQRAHSLFLASAEF..CNILSRVLSRARSR.PAKLYVYINELCTVLKAHSAKKKLNL-s.......
G1L3X7_AILME/60-158                  .....................g-GSSSSGGKKCYKLENEKLFEEFLELCKT..QTADHP.......EVVPFLYNRQQRAHSLFLASAEF..CNILSRVLSRAQSR.PAKLYVYINELCTVLKAHSAKKKLNL-a.......
S9XF62_9CETA/43-101                  .............ssitsssvp-----------------------------..------.......--------------TLFLASAEF..CNILSRVLSWAQSR.PAKLYVYINELCTVLKTQSAKKKLNL-a.......
S9X7D4_9CETA/132-237                 ....................rg--SSSPGGKKCYKLENEKLFKEFLELCKT..QTAXXXxxxxxxxXXXPFPYNRQQRAHSLFLASAEF..CNILSRVLSRAQSR.PAKLYVYINELCTVLKAHSAKKKLNL-a.......
F6ZLZ0_MACMU/25-123                  ....................rg--SSSSGGKKCYKLENEKLFQEFLELCKT..QTADHP.......EVVPFLSNRQQRAHSLFLASAEF..CNILSRVLSRAQSR.PSKLYVYINELCTVLKAHSAKKKLNL-a.......
I3M0F4_ICTTR/48-146                  .....................g-GSSSSGGKKCYKLENEKLFEEFLELCKT..QTSDHP.......EVVPFLYNRQQRAHSLFLASAEF..CNILSRVLSRARNR.PSKLYVYINELCTVLKAHSAKKKLNL-t.......
L5LIH5_MYODS/48-146                  ....................gg--NSSSGGKKCYKLENEKLFEEFLELCKA..QTGDHP.......DVVPFLCKRQQRAHALFLASAEF..CNILSRVLSRAQSR.PAKLYVYINELCTVLKAHSAKKKMNI-a.......
G3I6W2_CRIGR/48-146                  .....................g-RSRNSGGRKCYKLENERLFEEFLELCKV..QTSDHP.......EVVPFLHKQQQRAQSLFLASAEF..CNIMSRVLSRARNR.PAKLYVYINELCTVLKAHSNKKKLNL-a.......
H3DLF3_TETNG/56-154                  .....................p-CVSARREPHVLQAENERLFGEFVDHCLA..DTTDCP.......EVLDYLKTRHAKASPEYLCSVEF..RNTLGHCLSRAQAH.RSKTFVYINELCTVLTQHAAKKRQVT-t.......
#=GC SS_cons                         ....................XX--XXXXXSS---HHHHHHHHHHHHHHHHH..HTTT-T.......THHHHHHHHHHTC-CCHHCSHHH..HHHHHHHHHHHHH-.CCCHHHHHHHHHHHHHHCCSSTT--X-X.......
#=GC seq_cons                        .....................G..SSssGu+KCYKLENEKLF-EFLELCKh..pTuDHP.......EVVPFLpsRpQRApshFLASAEF..pNlLSRVLoRApuR.PuKlYVYINELCTVLKAHSsKKKlsL.u.......
//
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