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Database: Pfam
Entry: Deltaretro_Tax
LinkDB: Deltaretro_Tax
Original site: Deltaretro_Tax 
#=GF ID   Deltaretro_Tax
#=GF AC   PF05599.6
#=GF DE   Deltaretrovirus Tax protein
#=GF AU   Nicot S, Moxon SJ, Studholme DJ
#=GF SE   Pfam-B_8606 (release 8.0)
#=GF GA   25.00 25.00;
#=GF TC   26.40 26.30;
#=GF NC   20.00 19.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12404172
#=GF RT   Cross-reactivity between immunodominant human T lymphotropic
#=GF RT   virus type I tax and neurons: implications for molecular
#=GF RT   mimicry. 
#=GF RA   Levin MC, Lee SM, Morcos Y, Brady J, Stuart J; 
#=GF RL   J Infect Dis 2002;186:1514-1517.
#=GF RN   [2]
#=GF RM   11689633
#=GF RT   Rat CRM1 is responsible for the poor activity of human T-cell
#=GF RT   leukemia virus type 1 Rex protein in rat cells. 
#=GF RA   Hakata Y, Yamada M, Shida H; 
#=GF RL   J Virol 2001;75:11515-11525.
#=GF RN   [3]
#=GF RM   11046153
#=GF RT   Distinct p300-responsive mechanisms promote caspase-dependent
#=GF RT   apoptosis by human T-cell lymphotropic virus type 1 Tax protein. 
#=GF RA   Nicot C, Harrod R; 
#=GF RL   Mol Cell Biol 2000;20:8580-8589.
#=GF DR   INTERPRO; IPR008596;
#=GF CC   This family consists of Rex/Tax proteins from human and simian
#=GF CC   T-cell leukaemia viruses. The exact function of these proteins
#=GF CC   is unknown. Tax is the viral transactivator; is it a nuclear
#=GF CC   phosphoprotein that interacts with CREB, coactivator CBP/p300
#=GF CC   and PCAF to form a multiprotein complex, which activates viral
#=GF CC   LTR and stimulates virus expression. Tax is also involved in
#=GF CC   deregulated expression of numerous cellular genes leading to
#=GF CC   T-cell leukaemia. Rex is a nucleolar post transcriptional
#=GF CC   regulator that facilitates export to the cytoplasm of viral RNA
#=GF CC   not or incompletely spliced [personal communication, Dr. S
#=GF CC   Nicot].
#=GF SQ   33
#=GS Q82239_HTLV2/1-39     AC Q82239.1
#=GS Q50E55_9DELA/1-58     AC Q50E55.1
#=GS C6L852_9DELA/155-241  AC C6L852.1
#=GS Q9QNL6_9STL1/1-39     AC Q9QNL6.1
#=GS Q9EAB0_9STL1/1-39     AC Q9EAB0.1
#=GS O55268_HTLV2/1-39     AC O55268.1
#=GS O70647_9DELA/1-87     AC O70647.1
#=GS C9W1V9_9STL1/1-58     AC C9W1V9.1
#=GS P30II_HTL1C/155-241   AC P0CK17.1
#=GS Q88385_9DELA/9-38     AC Q88385.1
#=GS O12385_9STL1/1-65     AC O12385.1
#=GS P30II_HTL1A/155-241   AC P0C214.1
#=GS Q50E48_9DELA/1-58     AC Q50E48.1
#=GS C6L855_9DELA/1-87     AC C6L855.1
#=GS Q88384_9DELA/1-36     AC Q88384.1
#=GS Q82210_9DELA/1-39     AC Q82210.1
#=GS O55270_HTLV2/1-39     AC O55270.1
#=GS C9W1V8_9STL1/1-58     AC C9W1V8.1
#=GS Q50E53_9DELA/1-58     AC Q50E53.1
#=GS O55267_HTLV2/1-39     AC O55267.1
#=GS Q80794_9DELA/1-87     AC Q80794.1
#=GS Q50E46_9DELA/1-58     AC Q50E46.1
#=GS Q50E52_9DELA/1-58     AC Q50E52.1
#=GS Q50E45_9DELA/1-58     AC Q50E45.1
#=GS O55269_HTLV2/1-39     AC O55269.1
#=GS Q50E49_9DELA/1-58     AC Q50E49.1
#=GS Q50E54_9DELA/1-58     AC Q50E54.1
#=GS Q50E50_9DELA/1-58     AC Q50E50.1
#=GS Q80824_HTLV2/1-49     AC Q80824.1
#=GS Q50E47_HTLV3/1-58     AC Q50E47.1
#=GS Q50E43_9DELA/1-58     AC Q50E43.1
#=GS Q50E44_9DELA/1-58     AC Q50E44.1
#=GS Q50E51_9DELA/1-58     AC Q50E51.1
Q82239_HTLV2/1-39                .......-----------------------WRLCTGRLVSRLRWSMFHPPTSTCPPGHLSRAPAHLGPH-------------------------..............
Q50E55_9DELA/1-58                .......---------------FRIPSLRVWRLCTRRLVPHLWGTMFGPPTSSRPTGHLSRASDHLGPHRWTRYRLSSTV--------------..............
C6L852_9DELA/155-241             .......MLIISPLPRVWTESSFRIPSLRVWRLCTRRLVPHLWGTMFGPPTSSRPTGHLSRASDHLGPHRWTRYRLSSTVPYPSTPLLPHPENL..............
Q9QNL6_9STL1/1-39                .......----------------------VWRLCTRRLVPHLWGTMFSPPTSSRPTGHLSRASDHLGP--------------------------..............
Q9EAB0_9STL1/1-39                .......----------------------VWRLCTGRLVPHLWGTMFDPPTSSRPTGHLSRTSDHLGP--------------------------..............
O55268_HTLV2/1-39                .......-----------------------WRLCTGRLVSRLRWSMFHPPTSTCPPGHLSRAPAHLGPH-------------------------..............
O70647_9DELA/1-87                .......MPFFSPLSRFRTEPPLWIPSLRVWRLCSSRLVSRFRWALFHPPAPACPSRHLPGAPAHLGPHRWTRCRLSSPIPYPSAPLLPHPENL..............
C9W1V9_9STL1/1-58                .......---------------FRIPRLRFWRLCTGRLVPHLWGTMFGPPTSSRPTGHLSRAPDHLGPHRWTCYRLGSTV--------------..............
P30II_HTL1C/155-241              .......MLIISPLPRVWTESSFRIPSLRVWRLCTRRLVPHLWGTMFGPPTSSRPTGHLSRASDHLGPHRWTRYRLSSTVPYPSTPLLPHPENL..............
Q88385_9DELA/9-38                cpvsggl-------------------------------------PMFHPPTSTCPPGHLSRAETHL----------------------------a.............
O12385_9STL1/1-65                .......----------------------VWRLCPRRLVPHLWGTMLGPPTSSRPTGHLSRASGHLGPHRWTRYRLSSTIPYPSTPFLPHPENL..............
P30II_HTL1A/155-241              .......MLIISPLPRVWTESSFRIPSLRVWRLCTRRLVPHLWGTMFGPPTSSRPTGHLSRASDHLGPHRWTRYRLSSTVPYPSTPLLPHPENL..............
Q50E48_9DELA/1-58                .......---------------LWIPRLCVWRLCSSRLVPHLRWIMLPPPTSPRPPGHLPRAPDHLGPHRWTSCRLASPI--------------..............
C6L855_9DELA/1-87                .......MLIISPLPRVWTESSFRIPSLRVWRLCTRRLVPHLWGTMFGPPTSSRPTGHLSRASDHLGPHRWTRYRLSSTVPYPSTPLLPHPENL..............
Q88384_9DELA/1-36                .......-----------------------WRLCTGRLVSRLRWSTYVPPAY------------------------------------------idmpswppvqsrns
Q82210_9DELA/1-39                .......-----------------------WRLCTRRLVPHLWGTMLGPPTSSRPTGHLPRTSDHLGPH-------------------------..............
O55270_HTLV2/1-39                .......-----------------------WRLCTGRLVSRLRWSMFHPPTSTCPPGHLSRAPAHLGPH-------------------------..............
C9W1V8_9STL1/1-58                .......---------------FRIPRLRFWRLCTGRLVPHLWGTMFGPPTSSRPTGHLSRAPDHLGPHRWTCYRLGSTV--------------..............
Q50E53_9DELA/1-58                .......---------------FRIPSLRVWRLCTRRLVPHLWGTMFGPPTSSRPTGHLSRASDHLGPHRWTRYRLSSTV--------------..............
O55267_HTLV2/1-39                .......-----------------------WRLCTGRLVSRLRWSMFHPPTSTCPPGHLSRAPAHLGPH-------------------------..............
Q80794_9DELA/1-87                .......MLIISPLPRVWTESSFRIPSLRVSRLCTRRLVPHLWGTMFGPPTSSRPTGHLSRASDHLGPHRWTRYRLSSTVPYPSTPLLPHPENL..............
Q50E46_9DELA/1-58                .......---------------FRIPSLRVWRLCTRRLVPHLWGTMFGPPTSSRPTGHLSRASDHLGPHRWTRYRLSSTV--------------..............
Q50E52_9DELA/1-58                .......---------------FRIPSLRVWRLCTGRLVPHLWGTMFGPPTSSRPTGHLSRASDHLGPHRWTRYRLSSTV--------------..............
Q50E45_9DELA/1-58                .......---------------FRIPSLRVWRLCTGRLVPHLWGTMFGPPTSSRPTGHLSRASDHLGPHRWTCCRLSSTV--------------..............
O55269_HTLV2/1-39                .......-----------------------WRLCTGRLVSRLRWSMFHPPTSTCPPGHLSRAPAHLGPH-------------------------..............
Q50E49_9DELA/1-58                .......---------------FRIPRLRVWRLCTRRLVPHFWGTMFSPPTSSRPTGHLSRASNHLGPHRRTRYRLNSTV--------------..............
Q50E54_9DELA/1-58                .......---------------FRIPRLRVWRLCTRRLVPHFWGTMFSPPTSSRPTGHLSRASNHLGPHRWTRYRLGSTV--------------..............
Q50E50_9DELA/1-58                .......---------------FRIPSLRIWRLCTRRLVPHLWGTMFGPPTSSRPTGHLSRASDHLGPHRWTRYRLSSTV--------------..............
Q80824_HTLV2/1-49                .......--------------------------------------MFHPPTSTCPPGHLSRAPTHLGPHRWTRCQLSSPIPYPSPPLLPHPENL..............
Q50E47_HTLV3/1-58                .......---------------LRVPCLRFRRLCTGRLVPHFWGALFRSATPPCPTGHVPRTSDYLGPHRWTRCQLSSTI--------------..............
Q50E43_9DELA/1-58                .......---------------FRIPRLRVWRLCTRRLVPHFWGTMFSPPTSPRPTGHLSRASNHLGPHRWTCYRLNSTV--------------..............
Q50E44_9DELA/1-58                .......---------------FRISSLRVWRLCTRRLVPHLWGTMFGPPTSSRPTGHLSRASDYLGPHRWTRYRLSSTV--------------..............
Q50E51_9DELA/1-58                .......---------------FRIPSLRVWRLCTGRLVPHLWGTMFGPPTSSRPTGHLSRASDHLGPHRWTRYRLSSTV--------------..............
#=GC seq_cons                    ......................hhIPpLRVWRLCTtRLVPHLWGTMFuPPTSSRPTGHLSRASDHLGPHRWTphRLuSTl............................
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