GenomeNet

Database: Pfam
Entry: Dendrin
LinkDB: Dendrin
Original site: Dendrin 
#=GF ID   Dendrin
#=GF AC   PF15498.1
#=GF DE   Nephrin and CD2AP-binding protein, Dendrin
#=GF AU   Eberhardt RY, Coggill P, Hetherington K
#=GF SE   Jackhmmer:O94850
#=GF GA   27.00 27.00;
#=GF TC   109.60 47.40;
#=GF NC   20.10 19.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   16464232
#=GF RT   Postsynaptic recruitment of Dendrin depends on both dendritic
#=GF RT   mRNA transport and  synaptic anchoring.
#=GF RA   Kremerskothen J, Kindler S, Finger I, Veltel S, Barnekow A;
#=GF RL   J Neurochem. 2006;96:1659-1666.
#=GF RN   [2]
#=GF RM   17251388
#=GF RT   Expression and subcellular distribution of novel
#=GF RT   glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2,
#=GF RT   and 2310066E14Rik.
#=GF RA   Patrakka J, Xiao Z, Nukui M, Takemoto M, He L, Oddsson A,
#=GF RA   Perisic L, Kaukinen A, Szigyarto CA, Uhlen M, Jalanko H,
#=GF RA   Betsholtz C, Tryggvason K;
#=GF RL   J Am Soc Nephrol. 2007;18:689-697.
#=GF RN   [3]
#=GF RM   18356187
#=GF RT   Dendrin expression in glomerulogenesis and in human minimal
#=GF RT   change nephrotic syndrome.
#=GF RA   Duner F, Patrakka J, Xiao Z, Larsson J, Vlamis-Gardikas A,
#=GF RA   Pettersson E, Tryggvason K, Hultenby K, Wernerson A;
#=GF RL   Nephrol Dial Transplant. 2008;23:2504-2511.
#=GF RN   [4]
#=GF RM   21606645
#=GF RT   Dendrin location in podocytes is associated with disease
#=GF RT   progression in animal and human glomerulopathy.
#=GF RA   Asanuma K, Akiba-Takagi M, Kodama F, Asao R, Nagai Y, Lydia A,
#=GF RA   Fukuda H, Tanaka E, Shibata T, Takahara H, Hidaka T, Asanuma E,
#=GF RA   Kominami E, Ueno T, Tomino Y;
#=GF RL   Am J Nephrol. 2011;33:537-549.
#=GF RN   [5]
#=GF RM   17537921
#=GF RT   Nuclear relocation of the nephrin and CD2AP-binding protein
#=GF RT   dendrin promotes apoptosis of podocytes.
#=GF RA   Asanuma K, Campbell KN, Kim K, Faul C, Mundel P;
#=GF RL   Proc Natl Acad Sci U S A. 2007;104:10134-10139.
#=GF CC   Dendrin is a family of eukaryotic proteins found in the
#=GF CC   podocytes of the kidneys. Dendrin, originally identified in
#=GF CC   telencephalic dendrites, is a constituent of the slit diaphragm,
#=GF CC   SD, complex of podocytes, where it directly binds to nephrin and
#=GF CC   CD2AP. Kidney podocytes and their slit diaphragms (SDs) form the
#=GF CC   final barrier to urinary protein loss. SD proteins also
#=GF CC   participate in intracellular signalling pathways. Dendrin
#=GF CC   appears to prevent programmed cell death (apoptosis) through its
#=GF CC   binding to nephrin. The SD protein nephrin serves as a component
#=GF CC   of a signalling complex that directly links podocyte junctional
#=GF CC   integrity to actin cytoskeletal dynamics. Thus, dendrin is
#=GF CC   identified as an SD family with proapoptotic signalling
#=GF CC   properties that accumulates in the podocyte nucleus in response
#=GF CC   to glomerular injury.
#=GF SQ   28
#=GS DEND_MOUSE/55-708     AC Q80TS7.3
#=GS G1LKB8_AILME/51-689   AC G1LKB8.1
#=GS G3U5X4_LOXAF/1-626    AC G3U5X4.1
#=GS G1S849_NOMLE/281-615  AC G1S849.1
#=GS H0Y156_OTOGA/55-712   AC H0Y156.1
#=GS DEND_HUMAN/55-709     AC O94850.3
#=GS E2RTH4_CANFA/1-648    AC E2RTH4.1
#=GS DEND_RAT/55-707       AC P50617.3
#=GS G3R6N2_GORGO/55-710   AC G3R6N2.1
#=GS G1KYY8_ANOCA/1-76     AC G1KYY8.1
#=GS A6QPL7_BOVIN/1-622    AC A6QPL7.1
#=GS G3I6J1_CRIGR/354-463  AC G3I6J1.1
#=GS F1SJ13_PIG/55-705     AC F1SJ13.1
#=GS G3VKE5_SARHA/55-716   AC G3VKE5.1
#=GS F6SLS9_MACMU/1-656    AC F6SLS9.1
#=GS G1SV31_RABIT/2-510    AC G1SV31.1
#=GS G5AU33_HETGA/125-647  AC G5AU33.1
#=GS B9EGD7_HUMAN/1-655    AC B9EGD7.1
#=GS H2Q5U5_PANTR/55-708   AC H2Q5U5.1
#=GS G1KYY8_ANOCA/162-409  AC G1KYY8.1
#=GS G1S849_NOMLE/55-284   AC G1S849.1
#=GS H0UZS0_CAVPO/1-650    AC H0UZS0.1
#=GS G3I6J1_CRIGR/1-358    AC G3I6J1.1
#=GS G5AU33_HETGA/56-126   AC G5AU33.1
#=GS G1SV31_RABIT/508-612  AC G1SV31.1
#=GS F7BXX9_HORSE/1-630    AC F7BXX9.1
#=GS H2NH62_PONAB/1-656    AC H2NH62.1
#=GS F7IG77_CALJA/55-710   AC F7IG77.1
DEND_MOUSE/55-708                ...................MDIQASYWARGPQSRTCRLRPGSPEPPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPLGQ......PRPEPRNALRAAQPTGFPVFSRPERFGQVGRAPRP...SVLPQGDPG.VAWAGPWGGRRPGPPSYEAHLLLRGSAGTAPRR.RWDRPPPYVAPPSYEGPHRTLGTKRGPELSRAPTSSAPVPA.TTRTEGGRTKKRLDPRIYRDVLGAWGLRQGRGLLGGAPGCTAARARPESCKGAIEKSSGLVAAGLNSAGDSHSQGK.TTGGPGTDAALSRSAISSP--PRPVPRSRQHLRGSRKGKEG.SEQIWLPTCWLASPK....KPPVRHSQTLPRPWAPGGTGWKESLGQREG..AEHETLEVWKVTRRAHTLPRISRG......PAGREGIFVIDATCVVIKSQYVPTPRTQQGQLVPSGESCSVSDSLSQPKPChEEEGEGAAANPSVCQKRLLSSRVLNQPSEG....RECEAEVGQQGDSSL.EERSSSGLGFPVGEVNPRDAP....TQPGSQEHPTLGPAAPVCAGSLKGSE-AAGVPRRAGGGWARTPGPYAGALREAVSRIRRHTAPDSDSDEA.EDLSVHSGSSDGSDTDAPGASWRNERTLPALGN..TRPREGGKTAGLSDSIREIVDVISQTEE.GFIR-EDTRKTPQGNRE......................
G1LKB8_AILME/51-689              ...................MDFQASHWARGPQSRTCGPRPGSPEPPPRRPWASRVLQEATNWR---PAEARAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRNAPRVAQPVGPPAPSRPERLGPAGPPPRP...A--PQSDPG.AAWAGPWGGRRPGPPSYEAHLLLRGAAGTALRR.RWDRPPPYVAPPSYEGPHRTLGSKRGPEPSQAPASAASAPT.PARTEGGYAKKRLDPRIYRDVLGAWGLRQGRGLLGGSPGCGT---RLESSKGAAEKSLGLATAGLNSGSDGHAQAK.AAGSPSTETAPAGLATATPSPPRPAPRSRPHLKGSGEGKES.KEQTWLPKCWLPSLK....KQPPRQSQTLPRPWAPGGTGWRESLGHREG..AGPETLEGWKGTRRAHTLPRISRG......PARGEGVFVIDATCVVIRSQYVPTPRTQHVQLLPDGVPRVVGDAPTQPKPN.KEEGEGAAAFPSPCQKLLLSSPLSHQLGGG....RGFEAEGGEPADSSL.EERASRILGLPVGEVNLQD--....AQPGSPERSALGPAASGSTLRAEGSEEVAGAPRR-GRGWARTPGPYAGALREAVSRIRRHTAPDSDSDEA.AELSVHSGSSDGSDTEASGASWRNERP------..-RPGEGGKTAELSDSIREILDVISRTEE.ALFGTRDAKGIPQGNRE......................
G3U5X4_LOXAF/1-626               ...................MDSQTSHWARWTQSRTCGPRPGSPEPPPRRLWASRVLQEATNWRGGHPAEARAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRNAPRVAHPAVLPASSRPERFVPLGRAPRP...SAQPQSILG.AAWPGPWGGRRPGPPSYEAHLLLRGAAGTAPRR.RWDRPPPYVPPPSYDGPHRTLGTKRGPELTQAPASPDPAPI.PARTETGRAKKRLDPRIYRDVLGAWGLRQGRGLLGGSPGCGVARARSEFGKGAAERSLGLAVAGLSNGSDSHSAAK.APGSPGAKTVPTGPATATPSPPRPAPRSRPHLKGSREGKEN.VEQSWLLKRWISSPK....KQPPRHSQTLPRPWAPGGTGWKEYLGHREE..AETETLKGWKVTRRAHTLPRSSRR......PTCGEGVFVIDATCVVIRSQYVPTPQTQHMRLLPSGVPRVGGDAPSRLQCG.KEEGEGPAAFPSPCQKLLSSSGLSHQPSAG....RGSEAEGGEPEDSSL.QERASRILGLPVSEVNLRDVP....RQPGSPEHPALGPAASGSVGSAEGSKEVTAVPRRVGRSWARTPGPYAGALREAVSRIRRHTAPDSDSDEA.AELSVHSGSSDGSDTEASGTFWRSEQTQPGVGGptAEPREGGKRVEL----------------.-----------------......................
G1S849_NOMLE/281-615             .................ke----------------------------------------------------------------------------------..------......-----------------------------------...---------.---------------------------------.-----------------------------------------.----------------------------------------------------------------------------.-----------------------------------------.GNRIWFPKCWIPPLK....SNRPAISQTLPRPWAPGGTGWRESLGLGEG..AGPETLEGWKATRRAHTLPRSSQG......PSRGEGVFVIDATCVVIRSQYVPTPRTQQVQLLPSGVTRVVGDSPSQSKPG.KEEGEGATVFPSPCQKRLSSSRLLHQPGGG....RGGEAEGGRPEDSSL.EERTSRILGLPAPEVNLRDAP....TQPGSPEHQALGPAASGTQGTAEGSG-VAVVQRRAGRVWARTPAPYAGALREAVSRIRRHTAPDSDTDEA.EELSVHSGSSDGSDTEAPGASWRNERTLPGVGN..SSPEEDGKTAELSDSVGEILDVMSQTEE.VLFGVRDIRGTQQGNRK......................
H0Y156_OTOGA/55-712              ...................MDFQANHWARGSQSRTCGPRPGSPEVPPRRPWASRVLQEATNWRAGSLAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRLEPRNAPRAAQPARLLALSPPERLGPVGRAPRS...PAQPHRDPG.SAWAGPWGGRRPGPPSYEAHLLLRGSTGTAPRR.RWDRPPPYVAPPSYEGPHRTLGTKRGPALSQAPTLSAPAPT.PARTEGGRTKKRLDPRIYRDVLGAWGLRQGQGLLGGSPGCGAAIARPEFGKGAAEKSVGLAAAGLNSGSYSHSQAK.ATGRPSTKTAPSGSATATPSPPRPTPRARQHLKGSREGKEG.REPIWFPKCWIPSPKgslkRQPARHSQTLPRPWAPGGTGWKESLGYREG..VGPEALEGWKTTRRAHTLPRSSRR......PAPGEGVFVIDATCVVIRSQYVPTPQTQQVQLLPSGVPRVVGDAPSQPKAG.KEEGEGATVSPPPCQKLLLSSRLLHQPGQG....LGCEAEGGKLGDTLL.EERASRILGLPVGEVNLRDAP....TQPGTPEHQALGPAALGGIGRTEGSE-VVAVQWRAGRGWARNPGPYAGALREAVSRIRRHTAPDSDTDEA.EELSVHSSSYEGSDTEAPGASWRNERTLPGVGN..S--QEGGKTAELSDSIQEILDVISQTEE.ALFRARDTKGTPQENRE......................
DEND_HUMAN/55-709                ...................MDFQASHWARGFQNRTCGPRPGSPQPPPRRPWASRVLQEATNWRAGPLAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRNAPRVAQLAGLPAPLRPERLAPVGRAPRP...SAQPQSDPG.SAWAGPWGGRRPGPPSYEAHLLLRGSAGTAPRR.RWDRPPPYVAPPSYEGPHRTLGTKRGPGNSQVPTSSAPAAT.PARTDGGRTKKRLDPRIYRDVLGAWGLRQGQGLLGGSPGCGAARARPEPGKGVVEKSLGLAAADLNSGSDSHPQAK.ATGSAGTEIAPAGSATAAPCAPHPAPRSRHHLKGSREGKEG.-EQIWFPKCWIPSPK....KQPPRHSQTLPRPWAPGGTGWRESLGLGEG..AGPETLEGWKATRRAHTLPRSSQG......LSRGEGVFVIDATCVVIRSQYVPTPRTQQVQLLPSGVTRVVGDSPSQSKPG.KEEGEGATVFPSPCQKRLSSSRLLHQPGGG....RGGEAEGGRPGDSTL.EERTFRILGLPAPEVNLRDAP....TQPGSPEHQALGPAASGAQGRAEGSE-VAVVQRRAGRGWARTPGPYAGALREAVSRIRRHTAPDSDTDEA.EELSVHSGSSDGSDTEAPGASWRNERTLPEVGN..SSPEEDGKTAELSDSVGEILDVISQTEE.VLFGVRDIRGTQQGNRK......................
E2RTH4_CANFA/1-648               ...................MDFQASHWARGPQSRTCGPRPGSPEPPPRRPWASRVLQEATNWRAGPPAEARAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRSGPRVAQPVGPPAPSRPERLGPAGRPPRP...SAQPQSDPG.AAWAGPWGGRRPGPPSYEAHLLLRGAAGTALRR.RWDRPPPYVAPPSYEGPHRTLGSKRGPEPPQAPAPAASAPT.PARTEGGCAKKRLDPRIYRDVLGAWGLRQGRGLLGGSPGCGTAAPRPEAGKGAAERSLGPAAAGLSAGSDGRPQAR.AAGSPSAQTAPAGSAPAARSPPRPAPRARPRLKGSEEGKEN.REQSWLPKCWVPSRK....RQPPRQSQTLPRPWAPGGTGWSESPGLRAG..AGPS--EGGKGTRRAHTLPRSARG......PARGEGVFVIDATCVVIRSQYVPTPRTQHVQLLPAGVPRAAGDAPSPPGPS.QEEGEGAAALPSPCQKLLPSSRPSHQLGGG....RGFEAEGGKPADSSL.EERASRILGLPVGEVNLRDAP....AQPGSPERSALGPAASGGAAPAEGPEGVAAAPRRAGRGWARTPGPYAGALREAVSRIRRHTAPDSDSDEA.AELSVQSGSSDGSDTEASGASWRKEPP------..-RPGDGGKTAELSDSVRDILEVISRPEE.SLFGTRDSKGVPQGNRE......................
DEND_RAT/55-707                  ...................MDIQASYWARGPQNRTCRLRPGSPEPPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPLGQ......PRPELRNALRAAQPTGFPVFSRPERFGQVGRAPRP...SALPQGDPG.VAWAGPWGGRRPGPPSYEAHLLLRGAAGTAPRR.RWDRPPPYVAPPSYEGPHRTLGTKRGPELSRAPTSSAPVPA.TTRTEGGRTKKRLDPRIYRDVLGAWGLRQGRGLLGGAPGCAAARARPESCKGAVEKSSGLAAAGLNSGGDGHSQAK.TT-GPVTEVALSGSTISS--PPRPVPRSRQHLRGSRKGKEG.SEEMWLPTCWLSSPK....KPPVRHSQTLPRPWAPGGTGWKESLGQREG..TEHETLEVWKVTRRAHTLPRSSRG......PAGREGIFVIDATCVVIKSQYVPTPRTQQRQLAPSGESCIVSDSLRQPKPClEEEGKGAAANPSVCQKRLLSSRVLNPPSEG....REFEAEGRQQGDSSL.EERSSSGLGFPVGEVNPRDAP....THPGSPEHSTLGPAAPGCAGSVKGPE-AAGVPRRAGGGWARTPGPYAGALREAVSRIRRHTAPDSDSDEA.EDLSAHSGSSDGSDTDAPGASWRNERTLPAVGN..TRPREGGKTAELGDSIGEILDVISQTEE.GLVR-EDTRKTPQGKRE......................
G3R6N2_GORGO/55-710              ...................MDFQASHWARGFQNRTCGPRPGSPQPPPRRPWASRVLQEATNWRAGPLAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRNAPRAAQLAGIPAPLRPERLAPVGRAPRP...SAQPQSDPG.SAWAGPWGGRRPGPPSYEAHLLLRGSAGTAPRR.RWDRPPPYVAPPSYEGPHRTLGTKRGPGNSQVPTSSAPAAT.PARTEGGRTKKRLDPRIYRDVLGAWGLRQGQGLLGGSPGCGAARARPEPGKGVVEKSLGLAAADLNSGSDSHPQAK.ATGSAGTEIAPAGSATAAPCAPRPAPRSRHHLKGSREGKEG.REQIWFPKCWIPSPK....KQPPRHSQTLPRPWAPGGTGWRESLGLGEG..AGPETLEGWKGTRRAHTLPRSSQG......LSRGEGVFVIDATCVVIRSQYVPTPRTQQVQLLPSGVTRVVGDSPSQSKPG.KEEGEGVTVFPSPCQKRLSSSRLLHQPGGG....RGGEAEGGRPGDSSL.EERTFRILGLPAPEVNLRDAP....TQPGSPEHQALGPAASGAQGRAEGSE-VAMVQRRAGRGWARTPGPYAGALREAVSRIRRHTAPDSDTDEA.EELSVHSGSSDGSDTEAPGASWRNERTLPGVGN..SSPEEDGKTAELSDSVGEILDVISQTEE.VLFGVRDIRGTQQANRK......................
G1KYY8_ANOCA/1-76                ...................----------------------------------------------------------------------------------..------......-----------------------------------...---------.-------------PPSYEAHMLLRLRAGQGPRKeNWPHPPPYVAPPSYEAPHCTVRPQSKLLPCQHP--------.----------------------------------------------------------------------------.-----------------------------------------.---------------....------------------------------..------------------------......---------------------------------------------------.------------------------------....---------------.---------------------....----------------------------------------------------------------------.---------------------------------..----------------------------.-----------------hkgaltgkqiqtvgpkkygerv
A6QPL7_BOVIN/1-622               ...................MDFQASHWLRGPQSRTCGPRPGSPEPPPRRPWASRVLQEATNWRAGPPAEARAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRNALRVAHSAGLPAPSRPERLGSVGRPPRP...SAQPQSNPG.AAWAGPWGGRRPGPPSYEAHLLLRGAAGMAPRR.RWDRPPPYVAPPSYEGPHRTLGTKRGPEPSQARSSSTCAPT.--RTEGGCAKKRLDPRIYRDVLGAWGLRQGRGLLGGSPGCGTDRPRLESGKGPAEKSLRLAAAGLKSGSDGHPQAK.AAGSPGT--VPAGSATATPSPPRPTPRSRPHPRGSGEGREG.RDQTWLPKRWVPSIK....KQPPRHSQTLPRPWAPGGTGWIESLGHRGE..AGPETLEGWKATRRPHTLPRSSRG......PARGEGVFVIDATCVVIRSQYVPTPRTQHVQLLPAGVPRLVGNAPSQPKPN.KEEGEGAAVLPSPCRKLPLSSRPSLQPSEG....RGLEAERGKPADSSL.EERASRILGLPVGEVNLQDPP....TQPGSPEHSALGPAASRGARGAEGSEKVASGTRRAGRGWARAPGPYAGALREAVSRIRRHTAPDSDSDEA.AELSVHSSSSDASDTEASGASWRKERT------..-GPPEGGKTAELSGNAREI---------.-----------------es....................
G3I6J1_CRIGR/354-463             ................vht----------------------------------------------------------------------------------..------......-----------------------------------...---------.---------------------------------.-----------------------------------------.----------------------------------------------------------------------------.-----------------------------------------.---------------....------------------------------..------------------------......---------------------------------------------------.------------------------------....---------------.---------------------....-----------------------------------------QPGPYAGALREAVSRIRRHTAPDSDSDEA.EELSVHSGSSDGSDTDAPGASWRNEMTLPAVGN..TRPREGGKTAKPSDSIREVLDVISQTEEeGLFG-EDIRKTPQGKRE......................
F1SJ13_PIG/55-705                ...................MDFQASHWARWPQSRTCGPRPGSPEPPPRRPWASRVLQEATNWRAGPPAEARAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRNAPRVAQLAGLPASSRPERLGSVGRPSRPfapSAQPQSNPG.AAWAGPWGGRRPGPPSYEAHLLLRGAAGMAPRR.RWDRPPPYVAPPSYEGPHRTLGTKRGAEPSQAPASSAPAP-.-ARTEGVCTKKRLDPRIYRDVLGAWGLRQGRGLLGGSPGCGTGRPRLESGKGAAEKSLRPAAAGLKSGSDRHPQAK.AAGSPGAETLPAGSATVTPSPPRPAPRSRPHPTGSGEGREG.REQSWLPKCWIPSVK....KQLPRHSQTLPRPWAPGGTGWRESLGHREE..AGPETLEGWKATRRPHTLPRSSRG......RARGEGVFVIDATCVVIRSQYVPTPRTQHVQLLPAGVPRAVEDAPSPPKSN.KEEGEGATVFPSPSQKLPLSSRPSHQPGGG....RGLEAEGGKPADSSL.EERASRILGLPVGEVNLQDPP....TQPGSPEHSALGPAPSGGAGGAERSEEVAAVPQRAGRGWARTPGPYAGALREAVSRIRRHTAPDSDSDEA.AELSVHSGSSDGSDTEASGASWRSERT------..-GPREGGKTAELSDNVRGILDVISRTEE.VLFGAGDNKGTPQGNRE......................
G3VKE5_SARHA/55-716              ...................MDPTGGPWVQEPSSHRYGLDKKPPERLLRRAWVPRVLQEATNWGTGHPPEIRPREQEKRKAASQEREAKETERKRRKGGGVRkpRSPLGRarggggSRQEPGNVPKTAQPKVRQFPWLPGHLGPAGRPPRP...AAQSLRVPGtAARAGLRVGRPSGPPSYEAHLLLRGAAGPIPRK.RWDRPPPYVAPPSYDGPHRTLGAKRPPQLPGLPAPLAPAPTlEGKEREERPKKRLDPRIYRDVLGAWGIRQGRGALGGFPACGG----LGLGGKTSDKVSGVFLGGLNSNCSES----.-CSQPGANQI-ARAATLTSGTSQTTARTQVPLRDVSEGERA.GEQSWSRETGGPSPG....DQVAQHSQTLPRPWAPGSPREKESPGEGDGyqRSPKLPTDWKETHRAHTVPRSPHS......SAGENGVFVIDATCVVIRAQFVPTPQIQHVQLLSSPGPRNGGNSLAFQKPG.KEEGEEEQAFTSPCQKLLQNSRLFDQLSKGfsdaWGEGVEAGIPEDPSL.KERASRILGLPIRELDLGVSPnkcnSDPGGPNETA-----ARCADVARDSEPAPRVLRPAGPGRARDPGPYAGALREAVSRIRRHTAPDSDSDEA.PECGARSCSSEGSDTEASGTSRQPEQSLPGTSG..DQGEAGRRAGELRDCIREILDVICQTEE.ALFRAEGSAQGKQGGGH......................
F6SLS9_MACMU/1-656               ...................MDFQASHWARGFQNRTCGPRPGSPQPPPRRPWASRVLQEATNWRAGPLAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRNAPRAAQPAGLPATLRPERLALVGRAPRP...SAQPQSDPG.SAWAGPWGGRRPGPPSYEAHLMLRGSAGTAPRR.RWDRPPPYVAPPSYEGPHRTLGTKRGPGHSQVPTSSAPPPT.PARTEGGRTKKRLDPRIYRDVLGAWGLRQGQGLLGGSPGCGAARARPEPGKGVVEKSLGLAAADLNSGSDSHPQAK.ATGSAGTETTPAGSATAAPSAPRPAPRSRHHLKGSREGKEG.KEQIWFPKCWIPSPK....KQPPRHSQTLPRPWAPGGTGWRESLGLAEG..AGPETLEGWKATRRAHTLPRSSQG......PSRGEGVFVIDATCVVIRSQYVPTPRTQQVQLLPSGVTRVVGESASQSKPG.KEESEGATVFPSPCRKRLSNSRLLHQPGGG....RGGEAEGGRSGHSSL.EERTSRILGLPAPEVNLRDAP....TQPGSPEHQALGPGASGAQGRAEGSE-VAVVQRRAGRGWARTPGPYAGALREAVSRIRRHTAPDSDTDEA.EELSVHSGSSDGSDTEAPGASWRNERTLPGVGN..SSPEEDGKTAELSDSVGEILDVISQTEE.VLFGVRDIRGTQQGNRK......................
G1SV31_RABIT/2-510               .................ts---RSSHWARGPRSRTCRPRPGSPEPSPRRPWASRVLQEATN-------EVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGQ......PRPEPRNAPRAVQPAGLSGPSRRERLGPAGRAARP...SAPPHSETG.AAWAGPWGGRRPGPPSYEAHLLLRGAAATAPRR.RWDRPPPYVAPPSYEGPHRTLGTKRSPERSQASAASAPAPT.PARTEGGSARKRLDPRIYRDVLGAWGLRQGRGLLGGSPGCGAVRARPASGKGAAERGPVLPAAGLHGGSDRRFQATaVAGSPGSGTAPARPAAAPSSPPRPAPRSRHQLEGSREGKEGrREQVWLPRCWMLSPK....KQPSRQSQTLPRPWAPGGTGWRESPGHGDG..PGPA-------ARRAHTLPRCSRR......PAGGEGVFVIDATCVVIRSQYVPTPRAQQVQLLPSEMVRVVGDAPSPPKPG.PQQGEGASGSPFRVPRPQLVS-LSHRPGEGs..eGEGEAEGGKPGDSSSlEERASRILGLPVGEVNLRGAP....AQSGRPEHPA------------------------------------------------------------.---------------------------------..----------------------------.-----------------y.....................
G5AU33_HETGA/125-647             ..................x----------------------------------------------------------------------------------..------......-----------------------------------...---------.-VWAGPWRGRRPGPPSYEAHLLLRGAAGTAPRR.RWDQPPPYVAPPSFEWPHRTLGTKRGPQLSQVPTSSAPAPT.PARTEGGRAKKRLDPRIYRDVLGAWGLRPGRGLLGGSPGCAPARPRPESGKGSSKKSSGLAAAGLNSGRGSRSQAD.APGGPGTETAPAGSTPATPRSPRPAPRSGHHLKGSREGKEG.REHIWLPKCWIPSPK....KQPPHRSQTLPRPWAPGGTGWREFPGQREG..EGPEALGGWKATRRAHTLPRSSRA......PAPGEGIFVIDATCVVIRSQYVPAPRTQQVQLLPSGESRIVGHGPGQPKGS.KEEGERALGFPSACQKLLLSSRLLHQPSAG....HGCKAKGGKPEDSSL.EERASPVLGLLVGEVTLPCAA....VPPGIPERAASGPAAPADAGSVRGSK-LAAAPRPVGGGWARTPGPYAGALREAVSRIRRHTAPDSDSDEG.-ELSIHSGSSDGSDTEAPGASWRNERTLPVAGD..SQPGEGGKTAELNSSIREILDVISQTEQ.ALFPARDTKGTPQGSRE......................
B9EGD7_HUMAN/1-655               ...................MDFQASHWARGFQNRTCGPRPGSPQPPPRRPWASRVLQEATNWRAGPLAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRNAPRVAQLAGLPAPLRPERLAPVGRAPRP...SAQPQSDPG.SAWAGPWGGRRPGPPSYEAHLLLRGSAGTAPRR.RWDRPPPYVAPPSYEGPHRTLGTKRGPGNSQVPTSSAPAAT.PARTDGGRTKKRLDPRIYRDVLGAWGLRQGQGLLGGSPGCGAARARPEPGKGVVEKSLGLAAADLNSGSDSHPQAK.ATGSAGTEIAPAGSATAAPCAPHPAPRSRHHLKGSREGKEG.-EQIWFPKCWIPSPK....KQPPRHSQTLPRPWAPGGTGWRESLGLGEG..AGPETLEGWKATRRAHTLPRSSQG......LSRGEGVFVIDATCVVIRSQYVPTPRTQQVQLLPSGVTRVVGDSPSQSKPG.KEEGEGATVFPSPCQKRLSSSRLLHQPGGG....RGGEAEGGRPGDSTL.EERTFRILGLPAPEVNLRDAP....TQPGSPEHQALGPAASGAQGRAEGSE-VAVVQRRAGRGWARTPGPYAGALREAVSRIRRHTAPDSDTDEA.EELSVHSGSSDGSDTEAPGASWRNERTLPGVGN..SSPEEDGKTAELSDSVGEILDVISQTEE.VLFGVRDIRGTQQGNRK......................
H2Q5U5_PANTR/55-708              ...................MDFQASHWARGFQNRTCGPRPGSPQPPPRRPWASRVLQEATNWRAGPLAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRNAPRVAQLAGLPAPLRPERLAPVGRAPRP...SAQPQSDPG.SAWAGPWGGRRPGPPSYEAHLLLRGSAGTAPRR.RWDRPPPYVAPPSYEGPHRTLGTKRGPGNSQVPASSAPAAT.PARTEGGRTKKRLDPRIYRDVLGAWGLRQGQGLLGGSPGCGAARARPEPGKGVVEKSLGLAAADLNSGSDSHPQAK.ATGSAGTEIAPAGSATAAPCAPRPAPRSRHHLTGSREGKEG.REQIWFPKCWIPSPK....KQPPRHSQTLPRPWAPGGTGWRESLGLGEG..AGPETLEGWKATRRAHTLPRSSQG......LSRGEGVFVIDA-CVVIRSQYV-TPRTQQVQLLPSGVTRVVGDSPSQSKPG.KEEGEGATVFPSPCQKRLSSSRLLHQPGGG....RGGEAEGGRPGDSSL.EERTFRILGLPAPEVNLRDAP....TQPGSPEHQALGPAASGAQGRAEGSE-VAVVQRRAGRGWARTPGPYAGALREAVSRIRRHTAPDSDTDEA.EELSVHSGSSDGSDTEAPGASWRNERTLPGVGN..SSPEEDGKTAELSDSVGEILDVISQTEE.VLFGVRDIRGTQQGNRK......................
G1KYY8_ANOCA/162-409             pcppqhtlpvgwgfshavg----------------------------------------------------------------------------------..------......-----------------------------------...---------.---------------------------------.-----------------------------------------.----------------------------------------------------------------------------.-----------------------------------------.---------------....-------------WLPGDVRDGGSK-VGDK..HSRSILPKWKEPSHARDPG-GSQGslsklvPQKRGGLFVIDATCVVIQAHYIPAPRTERVRYLGQEGLDKVK-APLSPGPV.APASMEERAA--RILGLSVSELGFAEAGKG....KNVGAEMPEQKVNAG.STANLAMPKDICGTGQHKGAP....SPPASPREKTITPTESGCAQPQGKEEPE---PEPVFSPLSR---SYALDLKEAMSRIRRHTAPDSDTDEE.LE-------------------------------..----------------------------.-----------------kdch..................
G1S849_NOMLE/55-284              ...................MDFQASHWARGFQNRTCGPRPGSPQPPPRRPWASRVLQEATNWRAGPLAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRNAPRAAQLAGLPAPLRPERLAPVGRAPRP...SAQPQSDPG.SAWAGPWGGRRPGPPSYEAHLLLRGSAGTALRR.RWDRPPPYVAPPSYEGPHRTLGTKRGPGHSQVPTSSAPAPN.PARTEGGRTKKRLDPRIYRDK-------------------------------------------------------.-----------------------------------------.---------------....------------------------------..------------------------......---------------------------------------------------.------------------------------....---------------.---------------------....----------------------------------------------------------------------.---------------------------------..----------------------------.-----------------egn...................
H0UZS0_CAVPO/1-650               ...................MDFQASHWAPGSQSRTCRPRPGSPEPPPRRPWASRVLQEATN-------EVRAREQEKRKAASQEREAKETERKRRKAGGPR..RSPLGQ......SRQEPRNALRAAHPAGLSAPPRPERFGQVGRAPRP...PAQPQSDPG.AVWAGSWAGRRPGPPSYEAHLLLRGAAGTAPRR.RWDRPPPYVAPPSYEGPHRTLGTKRGPERSQGPTSSAPAPT.PARTEGGRAKKRLDPRIYRDVLGAWGLRQGRGLLGGSPGCAAAKPRLEFSKGGAEKSPGLATAALNSGSDSHFQAD.VPSSPGTEIALAGPVPATTSPPRTAPRFRHQLQGSREGKEG.RERIWLPKCWIPSPK....KQPPRHSQTLPRPWAPGGTGWRESLGQREG..VGPEALEDWKETRRPHTLPRSSRG......LARGEGVFVIDATCVVIRSQYVPTPRTQQVQLLPSGESRVVGDGPRQPNGS.KEEGERASVFSSACQKLLLSSRVLHQPSGE....PRCEAEGGKAEDSSHgGARGPHLWDSRAGEVHVPCAA....AQPASPEHAASGAAAPADAGSVRGSK-VTAAPRRAGGGWARTPGPYAGALREAVSRIRRHTAPDSDSDEGeEELSVHSGSSDGSDTEAPGASWWSERTPPETGG..TSPGEGGKTAELK-SIRETLDAISQPEQ.ALFPTRDTNGTPQGHRK......................
G3I6J1_CRIGR/1-358               ...................----------------------------------------------------------------------------------..------......-----------------------------------...---------.---------------------MLRGAAGSAPRR.RWDRPPPYVAPPSYEGPHRTLGTKRGPELSRASTSSAPVPA.TARTEGGRTKKRLDPRIYRDVLGAWGLRQGRGLLGGAPGCAAARAGSESCKGAIEKSSGLAAAGLNSGGYSHPQAK.ATGSPDTEAAPAGSTIHS--PPCPAPRSRQHLKGSREGKEG.SEHIWLPKCWLSSPK....KPPVRHSQTLPRPWAPGGTGWRESLGQREG..TEHETLEVWKATRRAHTLPRSSRG......PSRRDGIFVIDATCVVIKSQYVPTPRTQQVQRLPSREPSIVSDSPRQPKPC.QEEGEGVTANPSACQKLPLSSGISNQAGGG....SECEAERGEQGDSTR.EDRTSRILGFPVGEVTLRDVV...hTQ--------------------------------------------------------------------.---------------------------------..----------------------------.-----------------p.....................
G5AU33_HETGA/56-126              ...................MDFQASLWARGSQSRTCRPRPGSPEQPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEQEAKX------------..------......-----------------------------------...---------.---------------------------------.-----------------------------------------.----------------------------------------------------------------------------.-----------------------------------------.---------------....------------------------------..------------------------......---------------------------------------------------.------------------------------....---------------.---------------------....----------------------------------------------------------------------.---------------------------------..----------------------------.-----------------v.....................
G1SV31_RABIT/508-612             .................pa----------------------------------------------------------------------------------..------......-----------------------------------...---------.---------------------------------.-----------------------------------------.----------------------------------------------------------------------------.-----------------------------------------.---------------....------------------------------..------------------------......---------------------------------------------------.------------------------------....---------------.---------------------....---------------------------------------------YAGALREAVSRIRRHTAPDSDSDEA.EELSAHSGSSDGSDTEAPRASWRNEMTQPAAGN..PGPQEGGKRTEMSDSFRELLGAVSQTEE.ALFGARDPAETPQADRE......................
F7BXX9_HORSE/1-630               ...................-------------------RPGSPEPPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRLEPRNAPRVAQLAGLPAPSRPERLGLVGRPPRP...FAQLQSDPG.AAWARPWGGRRPGPPSYEAHLLLRGAAGTAPRR.RWDRPPPYVAPPSYEGPHRTLGAKRGPEPSRAPASSAPAPT.PARTEGGCTKKKLDPRIYRDVLGAWGLRQGRGLLGGSPGCRTARPKLESGKGAAEKSLGLAAAGLNSGSDGHPQAK.AAGSPGTETAPAGSATTTPSPPRPAPRSRAHLNGSGEGKEG.REHSWLRKCWIPSLK....KQLPRHSQTLPRPWAPGGTGWRESLGHREG..AGPETLEGRRATRRAHTLPRSSRG......PTPGEGVFVIDATCVVIRSQYVPTPRTQHVQLLSSGVPRVMGDAPSQAKPK.KEEGEGAALFPSSCQKLLTSSRLSHQPGEG....REFEAEGGKPADSSL.EERASRILGLPVGEVNLQDAR....TQPGNPEHSALGPAASGGAGSAEASEEAAVVPRRAGRGWARTPGPYAGALREAVSRIRRHTAPDSDSDEA.AELSVHSGSSDGSDTEASGAPWRNERP------..-RPREGGKT-ELSDSMGELLDVTSQTRE.ALFRARDTKGTPHGNRE......................
H2NH62_PONAB/1-656               ...................MDFQASHWVRGFQNRTCGPRPGSPQPPPRRPWASRVLQEATNWRAGPLAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRNAPRAAQLAGLPAPLRPERLAPVGRAPRP...SAQPQSDPG.SAWAGPWGGRRPGPPSYEAHLLLRGSAGTAPRR.RWDRPPPYVAPPSYEGPHRTLGTKRGPGHSQVPISSAPAAT.PARTEGGRTKKRLDPRIYRDVLGAWGLRQGQGLLGGSPGCGAARARPEPGKGVVEKSLGLAAADLNSGSHSHPQAK.ATGSAGTEIAPAGSATAAPCAPRPAPRSRHHLKGSREGKEG.REQIWFPKCWIPSPK....KQPPRHSQTLPRPWAPGGTGWRESLGLGEG..AGPETLEGWKATRRAHTLPRSSQG......PSRGEGVFVIDATCVVIRSQYVPTPGTQQVQLLPSGVTRVVGDSPSQSKPG.KEEGEGATVFPSPCQKRLSSSRLLHQPGGG....RGGEAEEGRPGDSSL.EERTSRILGLPAPEVNLRDAP....TQPGSPEHQALGPAASGAQGRAEGSE-VAVVQRRAGRGWARTPGPYAGALREAVSRIRRHTAPDSDTDEA.EELSVHSGSSDGSDTEAPGASWRNERTLPGVGN..SSPEEDGKTAELSDSVGEILDVISQTEE.VLFGVRDIRGTQQGNRK......................
F7IG77_CALJA/55-710              ...................MDFQASHWARGFQNRTCGPRPGSPQPPPRRPWASRVLQEATNWRAGPLAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPQGR......PRPEPRNAPRATQPAGLPAPSRPELLAQVGRAPRP...FAQPQSDPG.SAWAGPWGGRRPGPPSYEAHLLLRGSASTAPRR.RWDRPPPYVAPPSYEGPHRTLGTKRGPGHSQAPASSAPAPT.PSRTEGGRMKKRLDPRIYRDVLGAWGLRHGQGLLGGSPGCGAARARPESGKGFVEKSLGLAAADLNSGRDSHPQVK.ATGSPGTETAPAGSATAAPSAPRPAPRSRHHIKGSREGKKG.REQIWFPKCWIPSPK....KQPPRHSQTLPRPWAPGGTGWRESLGLGEG..AGPETLECWKATRRAHTLPRSSQG......PSRGEGVFVIDATCVVIRSQYVPTPRTQQVQLLPSGVPRVVGDVPSQSKPG.KEDSERATIFPSPCQKLPSSSHLLHQPSEG....GGGEAEGGRPGDSSL.EERTFSILGLPAPEVNLRDAP....TQPGSPEHQALGPAASGARSRAEGSE-VAVVQRRSGRGWARTPGPYAGALREAVSRIRRHTAPDSDTDEA.EELSVHSGSSDGSDTETLGASLRNERTLPGVGN..SPPEEGGKTAELSDRVGEIVDVVSETEE.VLFGVRDIKGTQQGNRK......................
#=GC seq_cons                    ...................MDhQASaWARG.QsRTCtPRPGSPpPPPRRPWASRVLQEATNWRuG..AEsRAREQEKRKAASQEREAKETERKRRKAGGAR..RSP.Gp......PR.EPRNA.RsAQ.sGhsus.RPERhu.sGRsPRP...sA.PQusPG.uAWAGPWGGRRPGPPSYEAHLLLRGuAGTAPRR.RWDRPPPYVAPPSYEGPHRTLGTKRGPt.SQsPsSSAPAPs.sARTEGGpsKKRLDPRIYRDVLGAWGLRQGpGLLGGSPGCusu+sR.EsuKGssEKS.GLAAAsLsSGucuHsQA+.ssGusuochsPAGuAsussssPRPsPRSR.HLcGSpEGKEG.pEphWhPKCWlPSsK....KQPsRHSQTLPRPWAPGGTGW+ESLGhtEG..sGPEsLEsWKsTRRAHTLPRSSpG......sutGEGVFVIDATCVVIRSQYVPTPRTQpVQLLPSGssRlVGDuPoQsKPs.KEEGEGAsshPSsCQKhL.SSRl.HQPutG....+shEAEGGcsuDSSL.EERssRILGLPssEVNLpDAP....oQPGSPEHpALGPAAsustutscGSE.ssss.RRuGtGWARTPGPYAGALREAVSRIRRHTAPDSDoDEA.tELSVHSGSSDGSDTEAsGASWRsERT.P.hus..spPpEsGKTAELSDSltEILDVlSpTEE.sLFtscD.+tT.QGsRc......................
//
DBGET integrated database retrieval system