GenomeNet

Database: Pfam
Entry: Dendrin
LinkDB: Dendrin
Original site: Dendrin 
#=GF ID   Dendrin
#=GF AC   PF15498.2
#=GF DE   Nephrin and CD2AP-binding protein, Dendrin
#=GF AU   Eberhardt RY, Coggill P, Hetherington K
#=GF SE   Jackhmmer:O94850
#=GF GA   27.00 27.00;
#=GF TC   109.20 35.20;
#=GF NC   21.40 21.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   16464232
#=GF RT   Postsynaptic recruitment of Dendrin depends on both dendritic
#=GF RT   mRNA transport and  synaptic anchoring.
#=GF RA   Kremerskothen J, Kindler S, Finger I, Veltel S, Barnekow A;
#=GF RL   J Neurochem. 2006;96:1659-1666.
#=GF RN   [2]
#=GF RM   17251388
#=GF RT   Expression and subcellular distribution of novel
#=GF RT   glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2,
#=GF RT   and 2310066E14Rik.
#=GF RA   Patrakka J, Xiao Z, Nukui M, Takemoto M, He L, Oddsson A,
#=GF RA   Perisic L, Kaukinen A, Szigyarto CA, Uhlen M, Jalanko H,
#=GF RA   Betsholtz C, Tryggvason K;
#=GF RL   J Am Soc Nephrol. 2007;18:689-697.
#=GF RN   [3]
#=GF RM   18356187
#=GF RT   Dendrin expression in glomerulogenesis and in human minimal
#=GF RT   change nephrotic syndrome.
#=GF RA   Duner F, Patrakka J, Xiao Z, Larsson J, Vlamis-Gardikas A,
#=GF RA   Pettersson E, Tryggvason K, Hultenby K, Wernerson A;
#=GF RL   Nephrol Dial Transplant. 2008;23:2504-2511.
#=GF RN   [4]
#=GF RM   21606645
#=GF RT   Dendrin location in podocytes is associated with disease
#=GF RT   progression in animal and human glomerulopathy.
#=GF RA   Asanuma K, Akiba-Takagi M, Kodama F, Asao R, Nagai Y, Lydia A,
#=GF RA   Fukuda H, Tanaka E, Shibata T, Takahara H, Hidaka T, Asanuma E,
#=GF RA   Kominami E, Ueno T, Tomino Y;
#=GF RL   Am J Nephrol. 2011;33:537-549.
#=GF RN   [5]
#=GF RM   17537921
#=GF RT   Nuclear relocation of the nephrin and CD2AP-binding protein
#=GF RT   dendrin promotes apoptosis of podocytes.
#=GF RA   Asanuma K, Campbell KN, Kim K, Faul C, Mundel P;
#=GF RL   Proc Natl Acad Sci U S A. 2007;104:10134-10139.
#=GF DR   INTERPRO; IPR026500;
#=GF CC   Dendrin is a family of eukaryotic proteins found in the
#=GF CC   podocytes of the kidneys. Dendrin, originally identified in
#=GF CC   telencephalic dendrites, is a constituent of the slit diaphragm,
#=GF CC   SD, complex of podocytes, where it directly binds to nephrin and
#=GF CC   CD2AP. Kidney podocytes and their slit diaphragms (SDs) form the
#=GF CC   final barrier to urinary protein loss. SD proteins also
#=GF CC   participate in intracellular signalling pathways. Dendrin
#=GF CC   appears to prevent programmed cell death (apoptosis) through its
#=GF CC   binding to nephrin. The SD protein nephrin serves as a component
#=GF CC   of a signalling complex that directly links podocyte junctional
#=GF CC   integrity to actin cytoskeletal dynamics. Thus, dendrin is
#=GF CC   identified as an SD family with proapoptotic signalling
#=GF CC   properties that accumulates in the podocyte nucleus in response
#=GF CC   to glomerular injury.
#=GF SQ   43
#=GS G3I6J1_CRIGR/353-463  AC G3I6J1.1
#=GS V8PD67_OPHHA/290-561  AC V8PD67.1
#=GS U6D8U0_NEOVI/1-380    AC U6D8U0.1
#=GS A6QPL7_BOVIN/1-622    AC A6QPL7.1
#=GS L5KD64_PTEAL/55-704   AC L5KD64.1
#=GS M3VU31_FELCA/55-705   AC M3VU31.1
#=GS L8Y728_TUPCH/55-157   AC L8Y728.1
#=GS G3VKE5_SARHA/55-716   AC G3VKE5.1
#=GS F1SJ13_PIG/55-705     AC F1SJ13.1
#=GS V8PD67_OPHHA/27-226   AC V8PD67.1
#=GS U3E267_CALJA/55-710   AC U3E267.1
#=GS F6SLS9_MACMU/1-656    AC F6SLS9.1
#=GS G1KYY8_ANOCA/1-73     AC G1KYY8.1
#=GS G1S849_NOMLE/280-615  AC G1S849.1
#=GS L8Y728_TUPCH/531-589  AC L8Y728.1
#=GS S9YFK7_9CETA/320-443  AC S9YFK7.1
#=GS F7BXX9_HORSE/1-630    AC F7BXX9.1
#=GS F7IG77_CALJA/55-710   AC F7IG77.1
#=GS E2RTH4_CANFA/55-702   AC E2RTH4.2
#=GS DEND_MOUSE/55-708     AC Q80TS7.3
#=GS G3U5X4_LOXAF/1-626    AC G3U5X4.1
#=GS G1LKB8_AILME/51-689   AC G1LKB8.1
#=GS H0Y156_OTOGA/55-712   AC H0Y156.1
#=GS DEND_HUMAN/55-709     AC O94850.3
#=GS S7Q1C7_MYOBR/1-356    AC S7Q1C7.1
#=GS DEND_RAT/55-707       AC P50617.3
#=GS L8ILA2_9CETA/1-590    AC L8ILA2.1
#=GS G3R6N2_GORGO/55-710   AC G3R6N2.1
#=GS H2NH62_PONAB/55-710   AC H2NH62.2
#=GS L8Y728_TUPCH/153-533  AC L8Y728.1
#=GS M3YTF1_MUSPF/55-701   AC M3YTF1.1
#=GS I3N3B4_SPETR/55-709   AC I3N3B4.1
#=GS G1SV31_RABIT/42-693   AC G1SV31.2
#=GS G5AU33_HETGA/125-647  AC G5AU33.1
#=GS S9YFK7_9CETA/439-511  AC S9YFK7.1
#=GS B9EGD7_HUMAN/1-655    AC B9EGD7.1
#=GS H2Q5U5_PANTR/55-708   AC H2Q5U5.1
#=GS H0UZS0_CAVPO/1-650    AC H0UZS0.1
#=GS G1S849_NOMLE/55-284   AC G1S849.1
#=GS G3I6J1_CRIGR/1-358    AC G3I6J1.1
#=GS G1KYY8_ANOCA/164-409  AC G1KYY8.1
#=GS G5AU33_HETGA/56-126   AC G5AU33.1
#=GS S7Q1C7_MYOBR/352-425  AC S7Q1C7.1
G3I6J1_CRIGR/353-463             ........................................................................................................vvht----------------------------------------------------------------------------------..------......---------------------------.--------...---------.---------------------------------.---------------------.--------------------...-------------------------------------------------.----------------------------.----------------------------------------.---------------....--------.--------.--------------....------------....------------......---.-----------------------------------------------.--------------------------------..----.....----------.---------------------....----------------------.----.----.-----.......-----QPGPYAGALREAVSRIRRHTAPDSDSDEA.EELSVHSGSSDGSDTDAPGASWRNEMTLPAVGNT..RPREGGKTAKPSDSIREVLDVISQTEEEGLFGEDIRKTPQGKRE...........................
V8PD67_OPHHA/290-561             ................................................................................................krsqvmplpchp----------------------------------------------------------------------------------..------......---------------------------.--------...---------.---------------------------------.---------------------.--------------------...-------------------------------------------------.----------------------------.----------------------------------------.---------------....------SQhTLPAGWGFsHAAGWCRSKRDGSRakekRCQDFFPRWKEPspsrKLAGSQPALSKS......MPRrHGGLFVIDATCVVIQAHYIPSPRMEQVCYLAQGEAGTIKSPTSPGSP.GPTSMEERAARILGLPLRELGATEAGQGIMTPkiPGPE.....NGAIPGDSSG.REKVKRVPSAPDSPRK----L....SGPPTPNHSQVGPAKQEPTYLAgKGSA.ASPC.PRRHGlpqrkdePGMSAQSQSYICDLKEAMSRIRRHTAPDSDTDEE.LE--------------------------------..--------------------------------------------kenngpr....................
U6D8U0_NEOVI/1-380               ............................................................................................................----------------------------------------------------------------------------------..------......---------------------------.--------...---------.--------------------------AGTALRR.RWDRPPPYVAPPSYEGPHRTL.GSKRGPEPSQAPTSAASAPI...PAGTEGGCTKKRLDPRIYRDVLGAWGLRQGRGLLGGSPGCGTAGPRLESlGKGAAEKSLGLAT----SGSDGHSQAKA.AVNPSTETAPAGLAAATPSPPRPAPRSRPHLKGSGEGKEN.REQSWLPKCWIPSLK....KQPPRHSQ.TLPRPWAP.GGTGWRESLGHREG....ARPETLEGWKGT....RRAHTLPRSSRG......PAR.GEGVFVIDATCVVIRSQYVPTPRTQHVQLLPDGVPRVVGDAPNQSKP.NKEEGEGAAAFPSPCQKRLLSSRLSHQLGGGH..GFEA.....EGGKPADSSL.EERASRILGLPVGEVNLQDAP....PQPGSPERSASGPAASGGTVGA.EGSEeGAAV.-----.......----------------------------------.----------------------------------..--------------------------------------------p..........................
A6QPL7_BOVIN/1-622               ............................................................................................................MDFQASHWLRGPQSRTCGPRPGSPEPPPRRPWASRVLQEATNWRAGPPAEARAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRNALRVAHSAGLPAPSRPERLG.SVGRPPRP...SAQPQSNPG.AAWAGPWGGRRPGPPSYEAHLLLRGAAGMAPRR.RWDRPPPYVAPPSYEGPHRTL.GTKRGPEPSQARSSSTCAPT...--RTEGGCAKKRLDPRIYRDVLGAWGLRQGRGLLGGSPGCGTDRPRLES.GKGPAEKSLRLAAAGLKSGSDGHPQAKA.AGSPGTV--PAGSATATPSPPRPTPRSRPHPRGSGEGREG.RDQTWLPKRWVPSIK....KQPPRHSQ.TLPRPWAP.GGTGWIESLGHRGE....AGPETLEGWKAT....RRPHTLPRSSRG......PAR.GEGVFVIDATCVVIRSQYVPTPRTQHVQLLPAGVPRLVGNAPSQPKP.NKEEGEGAAVLPSPCRKLPLSSRPSLQPSEGR..GLEA.....ERGKPADSSL.EERASRILGLPVGEVNLQDPP....TQPGSPEHSALGPAASRGARGA.EGSEkVASG.TRRAG.......RGWARAPGPYAGALREAVSRIRRHTAPDSDSDEA.AELSVHSSSSDASDTEASGASWRKERTGPP----..---EGGKTAELSGNAREI--------------------------es.........................
L5KD64_PTEAL/55-704              ............................................................................................................MDFQASHWARGPQSRTCGPRLGSPEPLPRRPWASRVLQEATNWRAGPPAEARAREQEKRKAASQEREAKETERKRRKAGGAR..RSPLGR......PCPEVRNAPRVAQHTGLPAPSRPERLG.LVWRPPRP...SAQLQSDPE.AAWAGPWGGRRPGPPSYEAHLLLRGAAGTAPRR.RWDRPPPYVAPPSYEGPHRTL.GTKRGPEPSQAPASSAPAPT...PARTEGGCTKKRLDPRIYRDVLGAWGLRQGRGLLGGSPGCGTARPRLEP.RKRATEKSLGLADAGQNNSSGGYPQAKA.AGSPGTATAPAGSAAATPSPPRPAPRSRPHVKGSWEGKEG.REQSWLPKCWISSLK....KQPPRLSQ.TLPRPWAP.GGTGWRDSLGHREG....AKTETLADWKAT....RRAHTLPRSSRG......PVR.GEGVFVIDATRVVIRSQYVPTPRTQHVQFLPAGVPRPEGDALGQPKP.NKKEGKGAAVFPPPCQKLQLSSRLSHQQGGGR..GFEA.....EGGKPADSSL.EERASRILGLPMGEVNLQKVP....SQPVSSEHSALSPVASGGAGSA.KGLReVVAV.PRPTN.......RSWTRIPGPYAGALREAVSRIRRHTAPDSDSDEA.AELSVHSGSSDGSDTEASGASWRNERIRPQ----..---EGRKTAELSDSIREIIDVISRTEEALFGARDTKGTPQGNRE...........................
M3VU31_FELCA/55-705              ............................................................................................................MDFQASHWARGPQSRTCGPRSGSPEPPPRRPWASRVLQEATNWRAGPPAEARAREQEKRKAASQEREAKETERKRRKAGGAR..RSPLGR......PRPEPRNAPRVAQPVGPSAPSRPERLG.LAGRPPRP...SAQPQSDPG.AAWAGPWGGRRSGPPSYEAHLLLRGAAGTALRR.RWDRPPPYVAPPSYEGPHRTL.GSKRGPEPSQAPASAACAPT...PARTEGGFTKKRLDPRIYRDVLGAWGLRQGRGLLGGSPGCGTARPRLES.GKGAVEKSLGLASAGPNSGSDSHPQAKA.VGSPSSETAPAGLAAATPSPPRPAPRSRPHLKGPGEGKES.REQSWLPKGWIPSLK....RQPPRHSQ.TLPRPWAP.GGTGWRESLGHREG....AGPETLEGWKGA....RRAHTLPRSSRG......PAR.GEGVFVIDATCVVIRSQYVPTPRTQHVQLLPNGVPRVGGDAPNQPKP.NKEEVEGVAAFPSPCQKLLLSSRLSHQLGGGR..GFEA.....EGGKPPDSSL.EERASRILGLPVGEVNLQDAP....AQPGSPERSVLGPPASGGAGSA.EGSEeVAAVpPRRAG.......RGWARTPGPYAGALREAVSRIRRHTAPDSDSDEA.AELSVHSGSSDGSDTEASGASWRNERPRPG----..---EGGKTAELSDSIREILDVINRTEEAFFGERDTKGMPQGNRE...........................
L8Y728_TUPCH/55-157              ............................................................................................................MDFQASHWARGLQSRTCGPRPGAPEPPPRRPWASRVLQEATNWRAGPPAELRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRNAPRAAQC-------------.--------...---------.---------------------------------.---------------------.--------------------...-------------------------------------------------.----------------------------.----------------------------------------.---------------....--------.--------.--------------....------------....------------......---.-----------------------------------------------.--------------------------------..----.....----------.---------------------....----------------------.----.----.-----.......----------------------------------.----------------------------------..--------------------------------------------a..........................
G3VKE5_SARHA/55-716              ............................................................................................................MDPTGGPWVQEPSSHRYGLDKKPPERLLRRAWVPRVLQEATNWGTGHPPEIRPREQEKRKAASQEREAKETERKRRKGGGVRkpRSPLGRarggggSRQEPGNVPKTAQPKVRQFPWLPGHLG.PAGRPPRP...AAQSLRVPGtAARAGLRVGRPSGPPSYEAHLLLRGAAGPIPRK.RWDRPPPYVAPPSYDGPHRTL.GAKRPPQLPGLPAPLAPAPTlegKEREE--RPKKRLDPRIYRDVLGAWGIRQGRGALGGFPACGGLG----L.GGKTSDKVSGVFLGGLNSNCSES-----.CSQPGAN-QIARAATLTSGTSQTTARTQVPLRDVSEGERA.GEQSWSRETGGPSPG....DQVAQHSQ.TLPRPWAP.GSPREKESPGEGDGy..qRSPKLPTDWKET....HRAHTVPRSPHS......SAG.ENGVFVIDATCVVIRAQFVPTPQIQHVQLLSSPGPRNGGNSLAFQKP.GKEEGEEEQAFTSPCQKLLQNSRLFDQLSKGF..-SDAwgegvEAGIPEDPSL.KERASRILGLPIRELDLGVSPnkcnSDPGGPNE-----TAARCADVA.RDSEpAPRV.LRPAG.......PGRARDPGPYAGALREAVSRIRRHTAPDSDSDEA.PECGARSCSSEGSDTEASGTSRQPEQSLPGTSGD..QGEAGRRAGELRDCIREILDVICQTEEALFRAEGSAQGKQGGG-h..........................
F1SJ13_PIG/55-705                ............................................................................................................MDFQASHWARWPQSRTCGPRPGSPEPPPRRPWASRVLQEATNWRAGPPAEARAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRNAPRVAQLAGLPASSRPERLG.SVGRPSRPfapSAQPQSNPG.AAWAGPWGGRRPGPPSYEAHLLLRGAAGMAPRR.RWDRPPPYVAPPSYEGPHRTL.GTKRGAEPSQAPASSAPAP-...-ARTEGVCTKKRLDPRIYRDVLGAWGLRQGRGLLGGSPGCGTGRPRLES.GKGAAEKSLRPAAAGLKSGSDRHPQAKA.AGSPGAETLPAGSATVTPSPPRPAPRSRPHPTGSGEGREG.REQSWLPKCWIPSVK....KQLPRHSQ.TLPRPWAP.GGTGWRESLGHREE....AGPETLEGWKAT....RRPHTLPRSSRG......RAR.GEGVFVIDATCVVIRSQYVPTPRTQHVQLLPAGVPRAVEDAPSPPKS.NKEEGEGATVFPSPSQKLPLSSRPSHQPGGGR..GLEA.....EGGKPADSSL.EERASRILGLPVGEVNLQDPP....TQPGSPEHSALGPAPSGGAGGA.ERSEeVAAV.PQRAG.......RGWARTPGPYAGALREAVSRIRRHTAPDSDSDEA.AELSVHSGSSDGSDTEASGASWRSERTGPR----..---EGGKTAELSDNVRGILDVISRTEEVLFGAGDNKGTPQGNRE...........................
V8PD67_OPHHA/27-226              lekrlmsdfspcrhcpsfhvlqdstnwhdaqfpagwgplkqeghwfsrkgwgkrttsspkaprhhspsydgynpvcqrdmnwganhttkgdpkapapggslvscrwnq----------------------------------------------------------------------------------..------......---------------------------.--------...--------G.ASAKKRRELPARAPPSYEAHMLLRLRAQQGPRKeNWSHPPPYLAPPSYEASHHRVqPQQRAGKSD-----------...-------------------------------------------------.----------------------------.----------------------------------------.---------------....--------.--------.--------------....------------....------------......---.-----------------------------------------------.--------------------------------..----.....----------.---------------------....----------------------.----.----.-----.......----------------------------------.----------------------------------..--------------------------------------------svgkliqngaakkyrereagcesepl.
U3E267_CALJA/55-710              ............................................................................................................MDFQASHWARGFQNRTCGPRPGSPQPPPRRPWASRVLQEATNWRAGPLAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPQGR......PRPEPRNAPRATQPAGLPAPSRPELLA.QVGRAPRP...FAQPQSDPG.SAWAGPWGGRRPGPPSYEAHLLLRGSASTAPRR.RWDRPPPYVAPPSYEGPHRTL.GTKRGPGHSQAPASSAPAPT...PSRTEGGRMKKRLDPRIYRDVLGAWGLRHGQGLLGGSPGCGAARARPES.GKGFVEKSLGLAAADLNSGRDSHPQVKA.TGSPGTETAPAGSATAAPSAPRPAPRSRHHIKGSREGKKG.REQIWFPKCWIPSPK....KQPPRHSQ.TLPRPWAP.GGTGWRESLGLGEG....AGPETLECWKAP....RRAHTLPRSSQG......PSR.GEGVFVIDATCVVIRSQYVPTPRTQQVQLLPSGVPRVVGDVPSQSKP.GKEDSERATIFPSPCQKLPSSSHLLHQPSEGG..GGEA.....EGGRPGDSSL.EERTFSILGLPAPEVNLRDAP....TQPGSPEHQALGPAASGARSRA.EGSE.VAVV.QRRSG.......RGWARTPGPYAGALREAVSRIRRHTAPDSDTDEA.EELSVHSGSSDGSDTETLGASLRNERTLPGVGNS..PPEEGGKTAELSDRVGEIVDVVSETEEVLFGVRDIKGTQQGNRK...........................
F6SLS9_MACMU/1-656               ............................................................................................................MDFQASHWARGFQNRTCGPRPGSPQPPPRRPWASRVLQEATNWRAGPLAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRNAPRAAQPAGLPATLRPERLA.LVGRAPRP...SAQPQSDPG.SAWAGPWGGRRPGPPSYEAHLMLRGSAGTAPRR.RWDRPPPYVAPPSYEGPHRTL.GTKRGPGHSQVPTSSAPPPT...PARTEGGRTKKRLDPRIYRDVLGAWGLRQGQGLLGGSPGCGAARARPEP.GKGVVEKSLGLAAADLNSGSDSHPQAKA.TGSAGTETTPAGSATAAPSAPRPAPRSRHHLKGSREGKEG.KEQIWFPKCWIPSPK....KQPPRHSQ.TLPRPWAP.GGTGWRESLGLAEG....AGPETLEGWKAT....RRAHTLPRSSQG......PSR.GEGVFVIDATCVVIRSQYVPTPRTQQVQLLPSGVTRVVGESASQSKP.GKEESEGATVFPSPCRKRLSNSRLLHQPGGGR..GGEA.....EGGRSGHSSL.EERTSRILGLPAPEVNLRDAP....TQPGSPEHQALGPGASGAQGRA.EGSE.VAVV.QRRAG.......RGWARTPGPYAGALREAVSRIRRHTAPDSDTDEA.EELSVHSGSSDGSDTEAPGASWRNERTLPGVGNS..SPEEDGKTAELSDSVGEILDVISQTEEVLFGVRDIRGTQQGNRK...........................
G1KYY8_ANOCA/1-73                ............................................................................................................----------------------------------------------------------------------------------..------......---------------------------.--------...---------.-------------PPSYEAHMLLRLRAGQGPRKeNWPHPPPYVAPPSYEAPHCTV.RPQS----------------...-------------------------------------------------.----------------------------.----------------------------------------.---------------....--------.--------.--------------....------------....------------......---.-----------------------------------------------.--------------------------------..----.....----------.---------------------....----------------------.----.----.-----.......----------------------------------.----------------------------------..--------------------------------------------kllpcqhphkgaltgkqiqtvgpkkyg
G1S849_NOMLE/280-615             ..........................................................................................................dk----------------------------------------------------------------------------------..------......---------------------------.--------...---------.---------------------------------.---------------------.--------------------...-------------------------------------------------.----------------------------.---------------------------------------E.GNRIWFPKCWIPPLK....SNRPAISQ.TLPRPWAP.GGTGWRESLGLGEG....AGPETLEGWKAT....RRAHTLPRSSQG......PSR.GEGVFVIDATCVVIRSQYVPTPRTQQVQLLPSGVTRVVGDSPSQSKP.GKEEGEGATVFPSPCQKRLSSSRLLHQPGGGR..GGEA.....EGGRPEDSSL.EERTSRILGLPAPEVNLRDAP....TQPGSPEHQALGPAASGTQGTA.EGSG.VAVV.QRRAG.......RVWARTPAPYAGALREAVSRIRRHTAPDSDTDEA.EELSVHSGSSDGSDTEAPGASWRNERTLPGVGNS..SPEEDGKTAELSDSVGEILDVMSQTEEVLFGVRDIRGTQQGNRK...........................
L8Y728_TUPCH/531-589             ..........................................................................................................ag----------------------------------------------------------------------------------..------......---------------------------.--------...---------.---------------------------------.---------------------.--------------------...-------------------------------------------------.----------------------------.----------------------------------------.---------------....--------.--------.--------------....------------....------------......---.-----------------------------------------------.--------------------------------..----.....----------.---------------------....----------------------.----.----.-----.......-----------------------------DSDEA.EEPSVHSGSSDGSDAEAPGASWRNERTLPGDGNP..RPGEGGKAAELRQ-------------------------------ypgds......................
S9YFK7_9CETA/320-443             .......................................................................................................qalvl----------------------------------------------------------------------------------..------......---------------------------.--------...---------.---------------------------------.---------------------.--------------------...-------------------------------------------------.----------------------------.----------------------------------------.---------------....--------.--------.--------------....------------....------------......---.-TGVFVIDATCVVIRSQYVPTPRTQHVQLLPAGVPRVVGDTPSQPKP.NKEEGEEAAVFPSPCQKLLLSSSLSHQPGGGR..RFEA.....EGGKPADSSL.EERASRILGLPVGEVNLQDAP....TLPAA-----------------.----.----.-----.......----------------------------------.----------------------------------..--------------------------------------------e..........................
F7BXX9_HORSE/1-630               ............................................................................................................-------------------RPGSPEPPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRLEPRNAPRVAQLAGLPAPSRPERLG.LVGRPPRP...FAQLQSDPG.AAWARPWGGRRPGPPSYEAHLLLRGAAGTAPRR.RWDRPPPYVAPPSYEGPHRTL.GAKRGPEPSRAPASSAPAPT...PARTEGGCTKKKLDPRIYRDVLGAWGLRQGRGLLGGSPGCRTARPKLES.GKGAAEKSLGLAAAGLNSGSDGHPQAKA.AGSPGTETAPAGSATTTPSPPRPAPRSRAHLNGSGEGKEG.REHSWLRKCWIPSLK....KQLPRHSQ.TLPRPWAP.GGTGWRESLGHREG....AGPETLEGRRAT....RRAHTLPRSSRG......PTP.GEGVFVIDATCVVIRSQYVPTPRTQHVQLLSSGVPRVMGDAPSQAKP.KKEEGEGAALFPSSCQKLLTSSRLSHQPGEGR..EFEA.....EGGKPADSSL.EERASRILGLPVGEVNLQDAR....TQPGNPEHSALGPAASGGAGSA.EASEeAAVV.PRRAG.......RGWARTPGPYAGALREAVSRIRRHTAPDSDSDEA.AELSVHSGSSDGSDTEASGAPWRNERPRPR----..---EGGK-TELSDSMGELLDVTSQTREALFRARDTKGTPHGNRE...........................
F7IG77_CALJA/55-710              ............................................................................................................MDFQASHWARGFQNRTCGPRPGSPQPPPRRPWASRVLQEATNWRAGPLAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPQGR......PRPEPRNAPRATQPAGLPAPSRPELLA.QVGRAPRP...FAQPQSDPG.SAWAGPWGGRRPGPPSYEAHLLLRGSASTAPRR.RWDRPPPYVAPPSYEGPHRTL.GTKRGPGHSQAPASSAPAPT...PSRTEGGRMKKRLDPRIYRDVLGAWGLRHGQGLLGGSPGCGAARARPES.GKGFVEKSLGLAAADLNSGRDSHPQVKA.TGSPGTETAPAGSATAAPSAPRPAPRSRHHIKGSREGKKG.REQIWFPKCWIPSPK....KQPPRHSQ.TLPRPWAP.GGTGWRESLGLGEG....AGPETLECWKAT....RRAHTLPRSSQG......PSR.GEGVFVIDATCVVIRSQYVPTPRTQQVQLLPSGVPRVVGDVPSQSKP.GKEDSERATIFPSPCQKLPSSSHLLHQPSEGG..GGEA.....EGGRPGDSSL.EERTFSILGLPAPEVNLRDAP....TQPGSPEHQALGPAASGARSRA.EGSE.VAVV.QRRSG.......RGWARTPGPYAGALREAVSRIRRHTAPDSDTDEA.EELSVHSGSSDGSDTETLGASLRNERTLPGVGNS..PPEEGGKTAELSDRVGEIVDVVSETEEVLFGVRDIKGTQQGNRK...........................
E2RTH4_CANFA/55-702              ............................................................................................................MDFQASHWARGPQSRTCGPRPGSPEPPPRRPWASRVLQEATNWRAGPPAEARAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRSGPRVAQPVGPPAPSRPERLG.PAGRPPRP...SAQPQSDPG.AAWAGPWGGRRPGPPSYEAHLLLRGAAGTALRR.RWDRPPPYVAPPSYEGPHRTL.GSKRGPEPPQAPAPAASAPT...PARTEGGCAKKRLDPRIYRDVLGAWGLRQGRGLLGGSPGCGTAAPRPEA.GKGAAERSLGPAAAGLSAGSDGRPQARA.AGSPSAQTAPAGSAPAARSPPRPAPRARPRLKGSEEGKEN.REQSWLPKCWVPSRK....RQPPRQSQ.TLPRPWAP.GGTGWSESPGLRAG....AGPS--EGGKGT....RRAHTLPRSARG......PAR.GEGVFVIDATCVVIRSQYVPTPRTQHVQLLPAGVPRAAGDAPSPPGP.SQEEGEGAAALPSPCQKLLPSSRPSHQLGGGR..GFEA.....EGGKPADSSL.EERASRILGLPVGEVNLRDAP....AQPGSPERSALGPAASGGAAPA.EGPEgVAAA.PRRAG.......RGWARTPGPYAGALREAVSRIRRHTAPDSDSDEA.AELSVQSGSSDGSDTEASGASWRKEPPRPG----..---DGGKTAELSDSVRDILEVISRPEESLFGTRDSKGVPQGNRE...........................
DEND_MOUSE/55-708                ............................................................................................................MDIQASYWARGPQSRTCRLRPGSPEPPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPLGQ......PRPEPRNALRAAQPTGFPVFSRPERFG.QVGRAPRP...SVLPQGDPG.VAWAGPWGGRRPGPPSYEAHLLLRGSAGTAPRR.RWDRPPPYVAPPSYEGPHRTL.GTKRGPELSRAPTSSAPVPA...TTRTEGGRTKKRLDPRIYRDVLGAWGLRQGRGLLGGAPGCTAARARPES.CKGAIEKSSGLVAAGLNSAGDSHSQGKT.TGGPGTDAALSRSA--ISSPPRPVPRSRQHLRGSRKGKEG.SEQIWLPTCWLASPK....KPPVRHSQ.TLPRPWAP.GGTGWKESLGQREG....AEHETLEVWKVT....RRAHTLPRISRG......PAG.REGIFVIDATCVVIKSQYVPTPRTQQGQLVPSGESCSVSDSLSQPKPcHEEEGEGAAANPSVCQKRLLSSRVLNQPSEGR..ECEA.....EVGQQGDSSL.EERSSSGLGFPVGEVNPRDAP....TQPGSQEHPTLGPAAPVCAGSL.KGSE.AAGV.PRRAG.......GGWARTPGPYAGALREAVSRIRRHTAPDSDSDEA.EDLSVHSGSSDGSDTDAPGASWRNERTLPALGNT..RPREGGKTAGLSDSIREIVDVISQTEEG-FIREDTRKTPQGNRE...........................
G3U5X4_LOXAF/1-626               ............................................................................................................MDSQTSHWARWTQSRTCGPRPGSPEPPPRRLWASRVLQEATNWRGGHPAEARAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRNAPRVAHPAVLPASSRPERFV.PLGRAPRP...SAQPQSILG.AAWPGPWGGRRPGPPSYEAHLLLRGAAGTAPRR.RWDRPPPYVPPPSYDGPHRTL.GTKRGPELTQAPASPDPAPI...PARTETGRAKKRLDPRIYRDVLGAWGLRQGRGLLGGSPGCGVARARSEF.GKGAAERSLGLAVAGLSNGSDSHSAAKA.PGSPGAKTVPTGPATATPSPPRPAPRSRPHLKGSREGKEN.VEQSWLLKRWISSPK....KQPPRHSQ.TLPRPWAP.GGTGWKEYLGHREE....AETETLKGWKVT....RRAHTLPRSSRR......PTC.GEGVFVIDATCVVIRSQYVPTPQTQHMRLLPSGVPRVGGDAPSRLQC.GKEEGEGPAAFPSPCQKLLSSSGLSHQPSAGR..GSEA.....EGGEPEDSSL.QERASRILGLPVSEVNLRDVP....RQPGSPEHPALGPAASGSVGSA.EGSKeVTAV.PRRVG.......RSWARTPGPYAGALREAVSRIRRHTAPDSDSDEA.AELSVHSGSSDGSDTEASGTFWRSEQTQPGVGGPtaEPREGGKRVEL---------------------------------...........................
G1LKB8_AILME/51-689              ............................................................................................................MDFQASHWARGPQSRTCGPRPGSPEPPPRRPWASRVLQEATNWR---PAEARAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRNAPRVAQPVGPPAPSRPERLG.PAGPPPRP...A--PQSDPG.AAWAGPWGGRRPGPPSYEAHLLLRGAAGTALRR.RWDRPPPYVAPPSYEGPHRTL.GSKRGPEPSQAPASAASAPT...PARTEGGYAKKRLDPRIYRDVLGAWGLRQGRGLLGGSPGCGT---RLES.SKGAAEKSLGLATAGLNSGSDGHAQAKA.AGSPSTETAPAGLATATPSPPRPAPRSRPHLKGSGEGKES.KEQTWLPKCWLPSLK....KQPPRQSQ.TLPRPWAP.GGTGWRESLGHREG....AGPETLEGWKGT....RRAHTLPRISRG......PAR.GEGVFVIDATCVVIRSQYVPTPRTQHVQLLPDGVPRVVGDAPTQPKP.NKEEGEGAAAFPSPCQKLLLSSPLSHQLGGGR..GFEA.....EGGEPADSSL.EERASRILGLPVGEVNLQDA-....-QPGSPERSALGPAASGSTLRA.EGSEeVAGA.PRR-G.......RGWARTPGPYAGALREAVSRIRRHTAPDSDSDEA.AELSVHSGSSDGSDTEASGASWRNERPRPG----..---EGGKTAELSDSIREILDVISRTEEALFGTRDAKGIPQGNRE...........................
H0Y156_OTOGA/55-712              ............................................................................................................MDFQANHWARGSQSRTCGPRPGSPEVPPRRPWASRVLQEATNWRAGSLAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRLEPRNAPRAAQPARLLALSPPERLG.PVGRAPRS...PAQPHRDPG.SAWAGPWGGRRPGPPSYEAHLLLRGSTGTAPRR.RWDRPPPYVAPPSYEGPHRTL.GTKRGPALSQAPTLSAPAPT...PARTEGGRTKKRLDPRIYRDVLGAWGLRQGQGLLGGSPGCGAAIARPEF.GKGAAEKSVGLAAAGLNSGSYSHSQAKA.TGRPSTKTAPSGSATATPSPPRPTPRARQHLKGSREGKEG.REPIWFPKCWIPSPKgslkRQPARHSQ.TLPRPWAP.GGTGWKESLGYREG....VGPEALEGWKTT....RRAHTLPRSSRR......PAP.GEGVFVIDATCVVIRSQYVPTPQTQQVQLLPSGVPRVVGDAPSQPKA.GKEEGEGATVSPPPCQKLLLSSRLLHQPGQGL..GCEA.....EGGKLGDTLL.EERASRILGLPVGEVNLRDAP....TQPGTPEHQALGPAALGGIGRT.EGSE.VVAV.QWRAG.......RGWARNPGPYAGALREAVSRIRRHTAPDSDTDEA.EELSVHSSSYEGSDTEAPGASWRNERTLPGVGNS..--QEGGKTAELSDSIQEILDVISQTEEALFRARDTKGTPQENRE...........................
DEND_HUMAN/55-709                ............................................................................................................MDFQASHWARGFQNRTCGPRPGSPQPPPRRPWASRVLQEATNWRAGPLAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRNAPRVAQLAGLPAPLRPERLA.PVGRAPRP...SAQPQSDPG.SAWAGPWGGRRPGPPSYEAHLLLRGSAGTAPRR.RWDRPPPYVAPPSYEGPHRTL.GTKRGPGNSQVPTSSAPAAT...PARTDGGRTKKRLDPRIYRDVLGAWGLRQGQGLLGGSPGCGAARARPEP.GKGVVEKSLGLAAADLNSGSDSHPQAKA.TGSAGTEIAPAGSATAAPCAPHPAPRSRHHLKGSREGKEG.-EQIWFPKCWIPSPK....KQPPRHSQ.TLPRPWAP.GGTGWRESLGLGEG....AGPETLEGWKAT....RRAHTLPRSSQG......LSR.GEGVFVIDATCVVIRSQYVPTPRTQQVQLLPSGVTRVVGDSPSQSKP.GKEEGEGATVFPSPCQKRLSSSRLLHQPGGGR..GGEA.....EGGRPGDSTL.EERTFRILGLPAPEVNLRDAP....TQPGSPEHQALGPAASGAQGRA.EGSE.VAVV.QRRAG.......RGWARTPGPYAGALREAVSRIRRHTAPDSDTDEA.EELSVHSGSSDGSDTEAPGASWRNERTLPEVGNS..SPEEDGKTAELSDSVGEILDVISQTEEVLFGVRDIRGTQQGNRK...........................
S7Q1C7_MYOBR/1-356               ............................................................................................................----------------------------------------------------------------------------------..------......---------------------------.--------...---------.---------------------------------.------PYVAPPSYEGPHRTL.GAKRGPEPSQAPVSAAPAQN...PARTEGGGTKKRLDPRIYRDVLGAWGLRQERGLLGGSPGCGTARPRLEP.RRGAAEKSLGPAAAGRNSGGDGHPRAKT.AGDPGGATAPAGSATETPSPPRPASRSRPHLQGPREGKEG.REQSWHPKSWIPSPK....KHPPPHSQ.TLPRPWAP.GGTGSREPLGRRGR....AGPW--EGWQAT....RRAHTLPRSSSG......PAR.GEGIFVIDATCVVIRSQYVPTPRTQRVQLLPAGVPRTVGDAPSPPKP.SKEEGEAAAALPSPCQKLLSSSRLSQQPHGGR..GFEA.....EGGKPADPSL.EERASRILGLPVDEVNLQDAP....TQPGSLGRSVSGPAASGAA---.----.----.-----.......----------------------------------.----------------------------------..--------------------------------------------e..........................
DEND_RAT/55-707                  ............................................................................................................MDIQASYWARGPQNRTCRLRPGSPEPPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPLGQ......PRPELRNALRAAQPTGFPVFSRPERFG.QVGRAPRP...SALPQGDPG.VAWAGPWGGRRPGPPSYEAHLLLRGAAGTAPRR.RWDRPPPYVAPPSYEGPHRTL.GTKRGPELSRAPTSSAPVPA...TTRTEGGRTKKRLDPRIYRDVLGAWGLRQGRGLLGGAPGCAAARARPES.CKGAVEKSSGLAAAGLNSGGDGHSQAKT.TG-PVTEVALSGST--ISSPPRPVPRSRQHLRGSRKGKEG.SEEMWLPTCWLSSPK....KPPVRHSQ.TLPRPWAP.GGTGWKESLGQREG....TEHETLEVWKVT....RRAHTLPRSSRG......PAG.REGIFVIDATCVVIKSQYVPTPRTQQRQLAPSGESCIVSDSLRQPKPcLEEEGKGAAANPSVCQKRLLSSRVLNPPSEGR..EFEA.....EGRQQGDSSL.EERSSSGLGFPVGEVNPRDAP....THPGSPEHSTLGPAAPGCAGSV.KGPE.AAGV.PRRAG.......GGWARTPGPYAGALREAVSRIRRHTAPDSDSDEA.EDLSAHSGSSDGSDTDAPGASWRNERTLPAVGNT..RPREGGKTAELGDSIGEILDVISQTEEGL-VREDTRKTPQGKRE...........................
L8ILA2_9CETA/1-590               ..........................................................................................................kg-----------------------------------------------------------RGASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRNALRVAHSAGLPAPSRPERLGgPVGRPPRP...TARPQSNPG.AAWAGPWGGRRPGPPSYEAHLLLRGAAGMAPRR.RWDRPPPYVAPPSYEGPHRTL.GTKRGPEPSQARSSSTCAPT...--RTEGGCAKKRLDPRIYRDVLGAWGLRQGRGLLGGSPGCGTDRPRLES.GKGPAEKSLRLAAAGLKSGSDGHPQAKA.AGSPGTV--PAGSATATPSPPRPTPRSRPHPRGSGEGREG.RDQTWLPKRWVPSIK....KQPPRHSQ.TLPRPWAP.GGTGWIESLGHRGE....AGPETLEGWKAT....RRPHTLPRSSRG......PAR.GEGVFVIDATCVVIRSQYVPTPRTQHVQLLPAGVPRLVGNAPSQPKP.NKEEGEGAAVLPSPCRKLPLSSRPSLQPSEGR..GLEA.....ERGKPADSSL.EERASRILGLPVGEVNLQDPP....TQPGSPEHSALGPAASRGARGA.EGSEkVASG.TRRAG.......RGWARAPGPYAGALREAVSRIRRHTAPDSDSDEA.AELSVHSSSSDASDTEASGASWRKERTGPP----..---EGGKTAELSGNAREIVGAISKTEEVLYGARDIKGTPQGNRE...........................
G3R6N2_GORGO/55-710              ............................................................................................................MDFQASHWARGFQNRTCGPRPGSPQPPPRRPWASRVLQEATNWRAGPLAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRNAPRAAQLAGIPAPLRPERLA.PVGRAPRP...SAQPQSDPG.SAWAGPWGGRRPGPPSYEAHLLLRGSAGTAPRR.RWDRPPPYVAPPSYEGPHRTL.GTKRGPGNSQVPTSSAPAAT...PARTEGGRTKKRLDPRIYRDVLGAWGLRQGQGLLGGSPGCGAARARPEP.GKGVVEKSLGLAAADLNSGSDSHPQAKA.TGSAGTEIAPAGSATAAPCAPRPAPRSRHHLKGSREGKEG.REQIWFPKCWIPSPK....KQPPRHSQ.TLPRPWAP.GGTGWRESLGLGEG....AGPETLEGWKGT....RRAHTLPRSSQG......LSR.GEGVFVIDATCVVIRSQYVPTPRTQQVQLLPSGVTRVVGDSPSQSKP.GKEEGEGVTVFPSPCQKRLSSSRLLHQPGGGR..GGEA.....EGGRPGDSSL.EERTFRILGLPAPEVNLRDAP....TQPGSPEHQALGPAASGAQGRA.EGSE.VAMV.QRRAG.......RGWARTPGPYAGALREAVSRIRRHTAPDSDTDEA.EELSVHSGSSDGSDTEAPGASWRNERTLPGVGNS..SPEEDGKTAELSDSVGEILDVISQTEEVLFGVRDIRGTQQANRK...........................
H2NH62_PONAB/55-710              ............................................................................................................MDFQASHWVRGFQNRTCGPRPGSPQPPPRRPWASRVLQEATNWRAGPLAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRNAPRAAQLAGLPAPLRPERLA.PVGRAPRP...SAQPQSDPG.SAWAGPWGGRRPGPPSYEAHLLLRGSAGTAPRR.RWDRPPPYVAPPSYEGPHRTL.GTKRGPGHSQVPISSAPAAT...PARTEGGRTKKRLDPRIYRDVLGAWGLRQGQGLLGGSPGCGAARARPEP.GKGVVEKSLGLAAADLNSGSHSHPQAKA.TGSAGTEIAPAGSATAAPCAPRPAPRSRHHLKGSREGKEG.REQIWFPKCWIPSPK....KQPPRHSQ.TLPRPWAP.GGTGWRESLGLGEG....AGPETLEGWKAT....RRAHTLPRSSQG......PSR.GEGVFVIDATCVVIRSQYVPTPGTQQVQLLPSGVTRVVGDSPSQSKP.GKEEGEGATVFPSPCQKRLSSSRLLHQPGGGR..GGEA.....EEGRPGDSSL.EERTSRILGLPAPEVNLRDAP....TQPGSPEHQALGPAASGAQGRA.EGSE.VAVV.QRRAG.......RGWARTPGPYAGALREAVSRIRRHTAPDSDTDEA.EELSVHSGSSDGSDTEAPGASWRNERTLPGVGNS..SPEEDGKTAELSDSVGEILDVISQTEEVLFGVRDIRGTQQGNRK...........................
L8Y728_TUPCH/153-533             ............................................................................................................----------------------------------------------------------------------------------..------......---------------------------.--------...---------.-------------------------AAQCAPRR.RWARPPPYVAPPSYEGPHRTL.GTKRGPAPSQPPTSSAPAVT...PARTEGGRSKKRLDPRIYRDVLGAWGLRQGRGLLGGSSGCGATRARPES.CKGAAEKSRRLATASLNNGSDGYSQAKA.TANPSRETAPSGSATATPSSPRPAPRSRHHLKSSREGKEG.REPIWIPKCWIPSPK....KQPPQHSQ.TLPRPWAP.GGTGWTESLGHRDR....AGPETPEGWKAT....RRAHTLPRSSRG......PAR.GEGVFVIDATRVVIRSQYVPTPQTQQVHLLPSGVPRTVGDAPSPPKP.QK-EGEEAVVFPSPYQKLLVNSRLLPQPGLGR..GYEA.....EGAKPGDSSL.EERASRILGLPVGEVNLRDTP....AQLGSPEHPALGPAALGSAGTA.EGQE.VA--.-----.......----------------------------------.----------------------------------..--------------------------------------------gd.........................
M3YTF1_MUSPF/55-701              ............................................................................................................MDFQASHWARGPQSRTCGPRPGSPEPPPRRPWASRVLQEATNWRAGPPAEARAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRNAPRVAQPVGPPAPSRPERLG.PAGRPPRP...SAQPQSDPG.AAWAGPWGGRRPGPPSYEAHLLLRGAAGTALRR.RWDRPPPYVAPPSYEGPHRTL.GSKRGPEPSQAPASAASAPI...PAGTEGGCTKKRLDPRIYRDVLGAWGLRQGRGLLGGSPGCGTAGPRLESlGKGAAEKSLGLAT----SGSDGHSQAKA.AVNPSTETAPAGLAAATPSPPRPAPRSRPHLKGSGEGKEN.REQSWLPKCWIPSLK....KQPPRHSQ.TLPRPWAP.GGTGWRESLGHREG....ARPGTLEGWKGT....RRAHTLPRSSRG......PAR.GEGVFVIDATCVVIRSQYVPTPRTQHVQLLPDGVPRVVGDAPNQSKP.NKEEGEGAAAFPSPCQKRLLSSRLSHHLGGGH..GFEA.....EGGKPADSSL.EERASRILGLPVGEVNLQDAP....PQSGSPERSASGPAASGGTVGA.EGSEeGAAV.PRRAG.......RGWPRTPGPYAGALREAVSRIRRHTAPDSDSDEA.AELSVHSGSSDGSDTEASGASWRNEQPRPG----..---EGGKTAELSDSIREILDVISRTEEAFFGTRDTKGTPQGNRE...........................
I3N3B4_SPETR/55-709              ............................................................................................................MDFQASHWARGPQNRTCRPSPGSPEPPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPVGQ......PRLEPRNVPRVAQPAGLPVPSRPGRLG.QVGRA-RP...SAQPQSDPG.APWAGPWGGRRPGPPSYETHLLLRGSAGTAPRR.RWDRPPPYVAPPCYEGPHRTL.GTKRGPEFSQAPISSAPTPT...PARTEGGRTKKKLDPRIYRDVLGAWGIRQGRGLLGGSPGCGEARARPES.DKGATEKSLGLAAAGLNNGSDRHSQAKT.TGSPGTEIAPSRSATASPSPPRPAPRSRHHYKGSREGKEG.REPIWLPKCWFPSPK....KQSPRHSQ.TLPRPWAP.GGTGWKEFLGPREG....TGSETLEGWKAT....RRAHTLPRSSRG......PAS.GEGVFVIDATCVVIRSQYVPTSRTQKVQPLPSGEPRVVGEAPRQPNP.CKEEGEGSEVFPSSDQKPLLSSLLLHQLGRGR..GGET.....EDGKPGESSL.EERASRILGLSVGEVNLPDAP....TQPGSPEHPTLGPSALGGAGGA.KGLE.VAVV.PRRAG.......GGWARTPGPYAGALREAVSRIRRHTAPDSDSDEA.EELSIHSGSSDGSDTETPGASWRNERTLSVVGNA..RPREGGKTAELSDSVQEILDVISQTEQALFGARDAKGTPQGNRE...........................
G1SV31_RABIT/42-693              ..........................................................................................................ts---RSSHWARGPRSRTCRPRPGSPEPSPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGQ......PRPEPRNAPRAVQPAGLSGPSRRERLG.PAGRAARP...SAPPHSETG.AAWAGPWGGRRPGPPSYEAHLLLRGAAATAPRR.RWDRPPPYVAPPSYEGPHRTL.GTKRSPERSQASAASAPAPT...PARTEGGSARKRLDPRIYRDVLGAWGLRQGRGLLGGSPGCGAVRARPAS.GKGAAERGPVLPAAGLHGGSDRRFQATAvAGSPGSGTAPARPAAAPSSPPRPAPRSRHQLEGSREGKEGrREQVWLPRCWMLSPK....KQPSRQSQ.TLPRPWAP.GGTGWRESPGHGDG....PGPA-------A....RRAHTLPRCSRR......PAG.GEGVFVIDATCVVIRSQYVPTPRAQQVQLLPSEMVRVVGDAPSPPKP.GPQQGEGASGSPFRVPRPQLVS-LSHRPGEGSegEGEA.....EGGKPGDSSSlEERASRILGLPVGEVNLRGAP....AQSGRPEHPALGPAAPAGAGCA.RGSG.GAAG.PRRAG.......GGWARAPGPYAGALREAVSRIRRHTAPDSDSDEA.EELSAHSGSSDGSDTEAPRASWRNEMTQPAAGNP..GPQEGGKRTEMSDSFRELLGAVSQTEEALFGARDPAETPQADRE...........................
G5AU33_HETGA/125-647             ...........................................................................................................x----------------------------------------------------------------------------------..------......---------------------------.--------...---------.-VWAGPWRGRRPGPPSYEAHLLLRGAAGTAPRR.RWDQPPPYVAPPSFEWPHRTL.GTKRGPQLSQVPTSSAPAPT...PARTEGGRAKKRLDPRIYRDVLGAWGLRPGRGLLGGSPGCAPARPRPES.GKGSSKKSSGLAAAGLNSGRGSRSQADA.PGGPGTETAPAGSTPATPRSPRPAPRSGHHLKGSREGKEG.REHIWLPKCWIPSPK....KQPPHRSQ.TLPRPWAP.GGTGWREFPGQREG....EGPEALGGWKAT....RRAHTLPRSSRA......PAP.GEGIFVIDATCVVIRSQYVPAPRTQQVQLLPSGESRIVGHGPGQPKG.SKEEGERALGFPSACQKLLLSSRLLHQPSAGH..GCKA.....KGGKPEDSSL.EERASPVLGLLVGEVTLPCAA....VPPGIPERAASGPAAPADAGSV.RGSK.LAAA.PRPVG.......GGWARTPGPYAGALREAVSRIRRHTAPDSDSDEG.-ELSIHSGSSDGSDTEAPGASWRNERTLPVAGDS..QPGEGGKTAELNSSIREILDVISQTEQALFPARDTKGTPQGSRE...........................
S9YFK7_9CETA/439-511             ..........................................................................................................lp----------------------------------------------------------------------------------..------......---------------------------.--------...---------.---------------------------------.---------------------.--------------------...-------------------------------------------------.----------------------------.----------------------------------------.---------------....--------.--------.--------------....------------....------------......---.-----------------------------------------------.--------------------------------..----.....----------.---------------------....----------------------.----.----.-----.......---------------------------------A.AELSVHSGSSDGSDTEPPGAAWRNERIGPQ----..---EGGK-TELSDNIRDSLDVISRTEEVLFGARDTKGTPQGNRE...........................
B9EGD7_HUMAN/1-655               ............................................................................................................MDFQASHWARGFQNRTCGPRPGSPQPPPRRPWASRVLQEATNWRAGPLAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRNAPRVAQLAGLPAPLRPERLA.PVGRAPRP...SAQPQSDPG.SAWAGPWGGRRPGPPSYEAHLLLRGSAGTAPRR.RWDRPPPYVAPPSYEGPHRTL.GTKRGPGNSQVPTSSAPAAT...PARTDGGRTKKRLDPRIYRDVLGAWGLRQGQGLLGGSPGCGAARARPEP.GKGVVEKSLGLAAADLNSGSDSHPQAKA.TGSAGTEIAPAGSATAAPCAPHPAPRSRHHLKGSREGKEG.-EQIWFPKCWIPSPK....KQPPRHSQ.TLPRPWAP.GGTGWRESLGLGEG....AGPETLEGWKAT....RRAHTLPRSSQG......LSR.GEGVFVIDATCVVIRSQYVPTPRTQQVQLLPSGVTRVVGDSPSQSKP.GKEEGEGATVFPSPCQKRLSSSRLLHQPGGGR..GGEA.....EGGRPGDSTL.EERTFRILGLPAPEVNLRDAP....TQPGSPEHQALGPAASGAQGRA.EGSE.VAVV.QRRAG.......RGWARTPGPYAGALREAVSRIRRHTAPDSDTDEA.EELSVHSGSSDGSDTEAPGASWRNERTLPGVGNS..SPEEDGKTAELSDSVGEILDVISQTEEVLFGVRDIRGTQQGNRK...........................
H2Q5U5_PANTR/55-708              ............................................................................................................MDFQASHWARGFQNRTCGPRPGSPQPPPRRPWASRVLQEATNWRAGPLAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRNAPRVAQLAGLPAPLRPERLA.PVGRAPRP...SAQPQSDPG.SAWAGPWGGRRPGPPSYEAHLLLRGSAGTAPRR.RWDRPPPYVAPPSYEGPHRTL.GTKRGPGNSQVPASSAPAAT...PARTEGGRTKKRLDPRIYRDVLGAWGLRQGQGLLGGSPGCGAARARPEP.GKGVVEKSLGLAAADLNSGSDSHPQAKA.TGSAGTEIAPAGSATAAPCAPRPAPRSRHHLTGSREGKEG.REQIWFPKCWIPSPK....KQPPRHSQ.TLPRPWAP.GGTGWRESLGLGEG....AGPETLEGWKAT....RRAHTLPRSSQG......LSR.GEGVFVIDA-CVVIRSQYV-TPRTQQVQLLPSGVTRVVGDSPSQSKP.GKEEGEGATVFPSPCQKRLSSSRLLHQPGGGR..GGEA.....EGGRPGDSSL.EERTFRILGLPAPEVNLRDAP....TQPGSPEHQALGPAASGAQGRA.EGSE.VAVV.QRRAG.......RGWARTPGPYAGALREAVSRIRRHTAPDSDTDEA.EELSVHSGSSDGSDTEAPGASWRNERTLPGVGNS..SPEEDGKTAELSDSVGEILDVISQTEEVLFGVRDIRGTQQGNRK...........................
H0UZS0_CAVPO/1-650               ............................................................................................................MDFQASHWAPGSQSRTCRPRPGSPEPPPRRPWASRVLQEATN-------EVRAREQEKRKAASQEREAKETERKRRKAGGPR..RSPLGQ......SRQEPRNALRAAHPAGLSAPPRPERFG.QVGRAPRP...PAQPQSDPG.AVWAGSWAGRRPGPPSYEAHLLLRGAAGTAPRR.RWDRPPPYVAPPSYEGPHRTL.GTKRGPERSQGPTSSAPAPT...PARTEGGRAKKRLDPRIYRDVLGAWGLRQGRGLLGGSPGCAAAKPRLEF.SKGGAEKSPGLATAALNSGSDSHFQADV.PSSPGTEIALAGPVPATTSPPRTAPRFRHQLQGSREGKEG.RERIWLPKCWIPSPK....KQPPRHSQ.TLPRPWAP.GGTGWRESLGQREG....VGPEALEDWKET....RRPHTLPRSSRG......LAR.GEGVFVIDATCVVIRSQYVPTPRTQQVQLLPSGESRVVGDGPRQPNG.SKEEGERASVFSSACQKLLLSSRVLHQPSGEP..RCEA.....EGGKAEDSSHgGARGPHLWDSRAGEVHVPCAA....AQPASPEHAASGAAAPADAGSV.RGSK.VTAA.PRRAG.......GGWARTPGPYAGALREAVSRIRRHTAPDSDSDEGeEELSVHSGSSDGSDTEAPGASWWSERTPPETGGT..SPGEGGKTAELK-SIRETLDAISQPEQALFPTRDTNGTPQGHRK...........................
G1S849_NOMLE/55-284              ............................................................................................................MDFQASHWARGFQNRTCGPRPGSPQPPPRRPWASRVLQEATNWRAGPLAEVRAREQEKRKAASQEREAKETERKRRKAGGAR..RSPPGR......PRPEPRNAPRAAQLAGLPAPLRPERLA.PVGRAPRP...SAQPQSDPG.SAWAGPWGGRRPGPPSYEAHLLLRGSAGTALRR.RWDRPPPYVAPPSYEGPHRTL.GTKRGPGHSQVPTSSAPAPN...PARTEGGRTKKRLDPRIYRDK----------------------------.----------------------------.----------------------------------------.---------------....--------.--------.--------------....------------....------------......---.-----------------------------------------------.--------------------------------..----.....----------.---------------------....----------------------.----.----.-----.......----------------------------------.----------------------------------..--------------------------------------------egn........................
G3I6J1_CRIGR/1-358               ............................................................................................................----------------------------------------------------------------------------------..------......---------------------------.--------...---------.---------------------MLRGAAGSAPRR.RWDRPPPYVAPPSYEGPHRTL.GTKRGPELSRASTSSAPVPA...TARTEGGRTKKRLDPRIYRDVLGAWGLRQGRGLLGGAPGCAAARAGSES.CKGAIEKSSGLAAAGLNSGGYSHPQAKA.TGSPDTEAAPAGST--IHSPPCPAPRSRQHLKGSREGKEG.SEHIWLPKCWLSSPK....KPPVRHSQ.TLPRPWAP.GGTGWRESLGQREG....TEHETLEVWKAT....RRAHTLPRSSRG......PSR.RDGIFVIDATCVVIKSQYVPTPRTQQVQRLPSREPSIVSDSPRQPKP.CQEEGEGVTANPSACQKLPLSSGISNQAGGGS..ECEA.....ERGEQGDSTR.EDRTSRILGFPVGEVTLRDVV....----------------------.----.----.-----.......----------------------------------.----------------------------------..--------------------------------------------htqp.......................
G1KYY8_ANOCA/164-409             ...........................................................................................ppqhtlpvgwgfshavg----------------------------------------------------------------------------------..------......---------------------------.--------...---------.---------------------------------.---------------------.--------------------...-------------------------------------------------.----------------------------.----------------------------------------.---------------....--------.-----WLP.GDVRDGGSK-VGDK....HSRSILPKWKEP....SHARD-PGGSQGslsklvPQK.RGGLFVIDATCVVIQAHYIPAPRTERVRYLGQEGLDKVKAPLSPGPV.APASMEERAAR---ILGLSVSELGFAEAGKGK..NVGA.....EMPEQKVNAG.STANLAMPKDICGTGQHKGAP....SPPASPREKTITPTESGCAQPQ.G-KE.EPE-.PEPVF.......SPLSR---SYALDLKEAMSRIRRHTAPDSDTDEE.LE--------------------------------..--------------------------------------------kdch.......................
G5AU33_HETGA/56-126              ............................................................................................................MDFQASLWARGSQSRTCRPRPGSPEQPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEQEAKX------------..------......---------------------------.--------...---------.---------------------------------.---------------------.--------------------...-------------------------------------------------.----------------------------.----------------------------------------.---------------....--------.--------.--------------....------------....------------......---.-----------------------------------------------.--------------------------------..----.....----------.---------------------....----------------------.----.----.-----.......----------------------------------.----------------------------------..--------------------------------------------v..........................
S7Q1C7_MYOBR/352-425             ..........................................................................................................sg----------------------------------------------------------------------------------..------......---------------------------.--------...---------.---------------------------------.---------------------.--------------------...-------------------------------------------------.----------------------------.----------------------------------------.---------------....--------.--------.--------------....------------....------------......---.-----------------------------------------------.--------------------------------..----.....----------.---------------------....----------------------.----.----.-----.......---------------------------------A.AELSAQSSSSDGSDTEASGAPWRSERAG------..-CREGGKTTQRHDSIREILDVISQTGEALSGERNTTGAPRRSR-e..........................
#=GC seq_cons                    ...............................................................................................................pss.Wh...ps+pht.c.GuPp..PRRsWASRVLQEATNWt....sEhRAREQEKRKAASQEREAKETERKRRKAGGsR..RSP.Gp......sR.EsRNs.Rssp.hh..h....thhs..hh.s.Rs........t..G.ssWAGsWsGRRsGPPSYEAHLLLRGuAGsAPRR.RWDRPPPYVAPPSYEGPHRTL.GoKRGPt.SQsPsSuAsAss...suRTEGGpsKKRLDPRIYRDVLGAWGLRQGpGLLGGSPGCusstsR.Es.sKGssEKS.sLAsAshpuGusu+sQA+s.sussusthsPuGsAshssssPRPsPRSR.HlpGStEGKEu.pEp.WhPKsWlsS.K....KQPsR+SQ.TLPRPWAP.GGTGW+ESLG.t-t....sssEsLEsWKsT....RRAHTLPRSSpG......sup.GEGVFVIDATCVVIRSQYVPTPRTQpVQLLPuGssRsVGDuPupsKP.sKEEGEtAsshPSsCQKh..SS+l.pQsutG+..shEA.....EGG+PuDSSL.EERssRILGLPssEVNLpDuP....sQPGSPE+tslGPAAsuststs.cGsc.ssss..R.sG.......tuWuRsPGPYAGALREAVSRIRRHTAPDSDoDEA.tELSlHSGSSDGSDTEAsGASWRsEpshPt.........EsGKsuELssshtEll-slSpTEpshhhhcD.pts.QupRc...........................
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