GenomeNet

Database: Pfam
Entry: DotA
LinkDB: DotA
Original site: DotA 
#=GF ID   DotA
#=GF AC   PF11388.6
#=GF DE   Phagosome trafficking protein DotA
#=GF AU   Pollington J, Finn RD
#=GF SE   Pfam-B_001493 (release 23.0)
#=GF GA   25.00 25.00;
#=GF TC   32.10 31.30;
#=GF NC   19.10 17.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   16423685
#=GF RT   The Legionella pneumophila global regulatory protein LetA
#=GF RT   affects DotA and Mip. 
#=GF RA   Shi C, Forsbach-Birk V, Marre R, McNealy TL; 
#=GF RL   Int J Med Microbiol. 2006;296:15-24.
#=GF RN   [2]
#=GF RM   9632267
#=GF RT   Legionella pneumophila DotA protein is required for early
#=GF RT   phagosome trafficking decisions that occur within minutes of
#=GF RT   bacterial uptake. 
#=GF RA   Roy CR, Berger KH, Isberg RR; 
#=GF RL   Mol Microbiol. 1998;28:663-674.
#=GF DR   INTERPRO; IPR021528;
#=GF CC   DotA is essential for intracellular growth in Legionella [1].
#=GF CC   DotA is thought to play an important role in regulating initial
#=GF CC   phagosome trafficking decisions either upon or immediately after
#=GF CC   macrophage uptake [2].
#=GF SQ   8
#=GS A0A098GHT5_TATMI/456-571  AC A0A098GHT5.1
#=GS A0A078KU97_9GAMM/468-573  AC A0A078KU97.1
#=GS A0A078KQA5_9GAMM/472-580  AC A0A078KQA5.1
#=GS G9ESC7_9GAMM/474-580      AC G9ESC7.1
#=GS D3HP79_LEGLN/494-609      AC D3HP79.1
#=GS A0A0A8UY75_LEGHA/487-601  AC A0A0A8UY75.1
#=GS Q5ZS33_LEGPH/485-589      AC Q5ZS33.1
#=GS A0A098G030_9GAMM/492-604  AC A0A098G030.1
A0A098GHT5_TATMI/456-571             .......................................t-DSNTGLDGSSFDASLPGSAF..GS.NgnlgC..SGN.YANLCVWLT.GgiPSQKLLKDASdSVA.NV........ISLINGSG.VVPT..L..STpt...fnATSTKA..IPPPGANTVFGFVNNSSMVNLPGQPGLTP--pq
A0A078KU97_9GAMM/468-573             .......................................t-DTNTGLDSSTIDTSNLSASFvgGT.G....CstTAP.FNNLCTWLS.G..NQGTVSTIIT.AIN.GS........TA-GNNPI.--PA..N..VS.......PTAHQA..VGSLGSSTATGYINNSVMVNLPGQPGMAP--ps
A0A078KQA5_9GAMM/472-580             .......................................t-DTNTGLDSSSIDVSSLLTPL..SSpG....C..NGT.FPSLCTWLS.K..YPSGLSAMQS.LTM.LI........DNYNPAAAtPAII..L..SV.......IPSASStpVLGNGSATTVGFINNSVLITLPGQPGMTP--pa
G9ESC7_9GAMM/474-580                 .......................................i-DSNTGLEKSSFDAAKLVKAF..KDgQ....C..TSD.YAPLCAWFG.G..VATPLGYVQT.LINaGN........TATNTSPI.QKPT..M..SG.......SPRRNA..ILTQAATSVYGLANNSIMVQLPGQPGLKPLT..
D3HP79_LEGLN/494-609                 vdpksgldgstfdaglimspfkvsdpstgastctaggnds---------------------..--.T....K..GQD.FSDLCVWFN.Q..NATAVTQIKT.LLT.NT........--LS--SN.KVPD..V..SK.......SL--PL..VSGDNATTVMGFLNNGLKMQTPGQPGAAPV-n.
A0A0A8UY75_LEGHA/487-601             ...............dqsvctptpsgtyfstscmqnafas---------------------..SG.Q....C..GAN.YGVLCEWMN.G..DNTSVNQVIG.LLD.GS........NVTSN-KL.SLPA..G..SSistvtggSGSTGA..QTGAVSSTVYGFITNSLMVNLSQQPGQTP--pk
Q5ZS33_LEGPH/485-589                 ........................................FDTGTGLDKSSFDPTQLTKPF..GK.T....C..QDP.YSLLCTWFQ.N..KSDKLIQIQS.LID.GV........PALGQDGV.KQPD..L..SD.......NPQRQS..VSGPLSSTVYGFVNNSMMVQLPGQPGIKPLT..
A0A098G030_9GAMM/492-604             ........................vsfngsktgmqgggpq---------------------..-N.I....C..KDPkYGPVCAWFGsN..ATAMLNQVQA.LID.GTfstedpknPGVAQQGD.ATPApkFgkTD.......IQGSSA..VTSVGSASVNGFVTNSLMIQLPGQPGIAPL-q.
#=GC seq_cons                        .......................................o.DosTGL-tSohDss...tsh..us.s....C..sus.YusLCsWhs.s..ssssLsplpo.Lls.Gs........suhussus.thPs..h..Ss.......ssupsA..VsusuSoTVhGFlNNSlMVpLPGQPGhsP..s.
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