GenomeNet

Database: Pfam
Entry: DotA
LinkDB: DotA
Original site: DotA 
#=GF ID   DotA
#=GF AC   PF11388.5
#=GF DE   Phagosome trafficking protein DotA
#=GF AU   Pollington J, Finn RD
#=GF SE   Pfam-B_001493 (release 23.0)
#=GF GA   25.00 25.00;
#=GF TC   32.10 31.30;
#=GF NC   19.00 17.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   16423685
#=GF RT   The Legionella pneumophila global regulatory protein LetA
#=GF RT   affects DotA and Mip. 
#=GF RA   Shi C, Forsbach-Birk V, Marre R, McNealy TL; 
#=GF RL   Int J Med Microbiol. 2006;296:15-24.
#=GF RN   [2]
#=GF RM   9632267
#=GF RT   Legionella pneumophila DotA protein is required for early
#=GF RT   phagosome trafficking decisions that occur within minutes of
#=GF RT   bacterial uptake. 
#=GF RA   Roy CR, Berger KH, Isberg RR; 
#=GF RL   Mol Microbiol. 1998;28:663-674.
#=GF DR   INTERPRO; IPR021528;
#=GF CC   DotA is essential for intracellular growth in Legionella [1].
#=GF CC   DotA is thought to play an important role in regulating initial
#=GF CC   phagosome trafficking decisions either upon or immediately after
#=GF CC   macrophage uptake [2].
#=GF SQ   5
#=GS A0A098GHT5_TATMI/456-571  AC A0A098GHT5.1
#=GS D3HP79_LEGLN/494-609      AC D3HP79.1
#=GS A0A0A8UY75_LEGHA/487-601  AC A0A0A8UY75.1
#=GS Q5ZS33_LEGPH/485-589      AC Q5ZS33.1
#=GS A0A098G030_9GAMM/492-604  AC A0A098G030.1
A0A098GHT5_TATMI/456-571             .......................................t-DSNTGLDGSSFDASLPGSAFGSNgnlgCSGN.YANLCVWLT.GgiPSQKLLKDASdSVANV........ISLINGSGVVPT..L..STpt...fnATSTKAIPPPGANTVFGFVNNSSMVNLPGQPGLTP--pq
D3HP79_LEGLN/494-609                 vdpksgldgstfdaglimspfkvsdpstgastctaggnds-----------------------T....KGQD.FSDLCVWFN.Q..NATAVTQIKT.LLTNT........--LS--SNKVPD..V..SK.......SL--PLVSGDNATTVMGFLNNGLKMQTPGQPGAAPV-n.
A0A0A8UY75_LEGHA/487-601             ...............dqsvctptpsgtyfstscmqnafas---------------------SGQ....CGAN.YGVLCEWMN.G..DNTSVNQVIG.LLDGS........NVTSN-KLSLPA..G..SSistvtggSGSTGAQTGAVSSTVYGFITNSLMVNLSQQPGQTP--pk
Q5ZS33_LEGPH/485-589                 ........................................FDTGTGLDKSSFDPTQLTKPFGKT....CQDP.YSLLCTWFQ.N..KSDKLIQIQS.LIDGV........PALGQDGVKQPD..L..SD.......NPQRQSVSGPLSSTVYGFVNNSMMVQLPGQPGIKPLT..
A0A098G030_9GAMM/492-604             ........................vsfngsktgmqgggpq----------------------NI....CKDPkYGPVCAWFGsN..ATAMLNQVQA.LIDGTfstedpknPGVAQQGDATPApkFgkTD.......IQGSSAVTSVGSASVNGFVTNSLMIQLPGQPGIAPL-q.
#=GC seq_cons                        ........................ss..huposhtsu.so.....................uss....Cuss.YusLCsWFs.s..sospLsQlpo.LlDGo........suLuptusslPs..l..Sc.......usuosAVoGssSoTVaGFVNNSLMVQLPGQPGlsPl.s.
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