GenomeNet

Database: Pfam
Entry: DotA
LinkDB: DotA
Original site: DotA 
#=GF ID   DotA
#=GF AC   PF11388.7
#=GF DE   Phagosome trafficking protein DotA
#=GF AU   Pollington J, Finn RD
#=GF SE   Pfam-B_001493 (release 23.0)
#=GF GA   25.00 25.00;
#=GF TC   26.00 31.30;
#=GF NC   23.90 18.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   16423685
#=GF RT   The Legionella pneumophila global regulatory protein LetA
#=GF RT   affects DotA and Mip. 
#=GF RA   Shi C, Forsbach-Birk V, Marre R, McNealy TL; 
#=GF RL   Int J Med Microbiol. 2006;296:15-24.
#=GF RN   [2]
#=GF RM   9632267
#=GF RT   Legionella pneumophila DotA protein is required for early
#=GF RT   phagosome trafficking decisions that occur within minutes of
#=GF RT   bacterial uptake. 
#=GF RA   Roy CR, Berger KH, Isberg RR; 
#=GF RL   Mol Microbiol. 1998;28:663-674.
#=GF DR   INTERPRO; IPR021528;
#=GF CC   DotA is essential for intracellular growth in Legionella [1].
#=GF CC   DotA is thought to play an important role in regulating initial
#=GF CC   phagosome trafficking decisions either upon or immediately after
#=GF CC   macrophage uptake [2].
#=GF SQ   25
#=GS A0A078KU97_9GAMM/468-573  AC A0A078KU97.1
#=GS A0A098GHT5_TATMI/456-571  AC A0A098GHT5.1
#=GS A0A0W0WRF4_9GAMM/475-579  AC A0A0W0WRF4.1
#=GS G9ESC7_9GAMM/474-580      AC G9ESC7.1
#=GS A0A0W0SPA2_9GAMM/493-607  AC A0A0W0SPA2.1
#=GS A0A0W0R0A3_9GAMM/496-610  AC A0A0W0R0A3.1
#=GS A0A0W1ADC9_9GAMM/484-593  AC A0A0W1ADC9.1
#=GS A0A0W0VPZ8_9GAMM/467-578  AC A0A0W0VPZ8.1
#=GS A0A0A8UY75_LEGHA/487-601  AC A0A0A8UY75.1
#=GS Q5ZS33_LEGPH/485-589      AC Q5ZS33.1
#=GS A0A0W0WMQ0_9GAMM/467-572  AC A0A0W0WMQ0.1
#=GS A0A0W0VHR9_9GAMM/455-563  AC A0A0W0VHR9.1
#=GS A0A0W0YSV7_9GAMM/469-583  AC A0A0W0YSV7.1
#=GS A0A0W0TLP6_9GAMM/485-589  AC A0A0W0TLP6.1
#=GS A0A0W0VBN6_9GAMM/465-582  AC A0A0W0VBN6.1
#=GS A0A0W0V2W0_9GAMM/472-574  AC A0A0W0V2W0.1
#=GS A0A0W0Y028_9GAMM/463-566  AC A0A0W0Y028.1
#=GS A0A0W0Z5I8_LEGSP/484-588  AC A0A0W0Z5I8.1
#=GS A0A078KQA5_9GAMM/472-580  AC A0A078KQA5.1
#=GS A0A0W0ZQ79_9GAMM/502-615  AC A0A0W0ZQ79.1
#=GS D3HP79_LEGLN/494-609      AC D3HP79.1
#=GS A0A0W1AF93_9GAMM/474-578  AC A0A0W1AF93.1
#=GS A0A0W0XZF2_9GAMM/456-564  AC A0A0W0XZF2.1
#=GS A0A0W0THF1_9GAMM/481-589  AC A0A0W0THF1.1
#=GS A0A098G030_9GAMM/492-604  AC A0A098G030.1
A0A078KU97_9GAMM/468-573             .......................................t-DTNTGLDS..STIDT.S..NLSASFv...gG..T..G......Cs......tT..AP.FNNLCTWLS.G..NQGTVSTIIT.AIN........GS........TA.-GN........NP..I.--....PA..N..V.S.......P..TA..HQ.....A..VG...SLGSSTATGYINNSVMVNLPGQPGMAP--ps.
A0A098GHT5_TATMI/456-571             .......................................t-DSNTGLDG..SSFDA.S..LPGSAF.....G..S..Ngn..lgC........S..GN.YANLCVWLT.GgiPSQKLLKDASdSVA........NV........IS.LIN........GS..G.VV....PT..L..S.Tpt...fnA..TS..TK.....A..IP...PPGANTVFGFVNNSSMVNLPGQPGLTP--pq.
A0A0W0WRF4_9GAMM/475-579             ........................................FDSNTGLDT..STFDP.T..NLISSF.....GsnK..T......C........V..GP.YALLCSWFG.G..DKAPLDKVQS.VIN........GS........-S.LG-........DM..V.QK....PS..L..K.D.......D..AQ..RK.....V..VN...NLQSSTVYGFINNSVMVRLPGQPGIAPL-q..
G9ESC7_9GAMM/474-580                 .......................................i-DSNTGLEK..SSFDA.A..KLVKAF.....K..D.gQ......C........T..SD.YAPLCAWFG.G..VATPLGYVQT.LIN.......aGN........TA.TNT........SP..I.QK....PT..M..S.G.......S..PR..RN.....A..IL...TQAATSVYGLANNSIMVQLPGQPGLKPLT...
A0A0W0SPA2_9GAMM/493-607             .......................................t-DTKTGLSG..SKFDL.T..TVLKSF.....G..E..Tt...gkC.......aT..GT.QGNLCVWLG.G..SSSAITPVIG.LIN........GS........NT.TGQ........PG..Q.PQlptsNT..I..S.D.......ItgTK..GD.....A..YS...GGYSSTTFGYINNALMLHLASQPGLTP--pa.
A0A0W0R0A3_9GAMM/496-610             .......................................t-DTNTGIEG..STYKG.Q..QLV---.....-..-..S......C........S..GN.YSIVCDWFQ.N..DLFQLQSITT.LVN........GNt.....ppPSwVGTpppsspvpSN..I.PT....PS..L..KpG.......NppPA..PP.....V..YS...GANASTVYGFTSNSNALKLPDQPGQKPL-q..
A0A0W1ADC9_9GAMM/484-593             .......................................i-DSNTGLGG..SAFTA.T..ALTSAFp..gqG..SnsQ......C........DpdAP.YANLCTWFG.K..DQTKLTNVVN.LIT........GG........GS.ASL........PS..P.SY....PP..-..-.G.......D..SL..TA.....D..TN...KPTSSSVYSFINNSTLLKTVGQNDIKPLT...
A0A0W0VPZ8_9GAMM/467-578             .......................................t-DTGTGLNG..SKVDL.S..QLNNAFv...gG..KcsT......G........E..TP.SVYLCNWMN.G..DPTLINQVIG.LIN........GA........N-.LGS........-P..L.DM....PG..S..S.A.......I..PG..LQagtsdA..QT...GAFSSTVYGFLQNSMMVQLPDQPGQSP--pq.
A0A0A8UY75_LEGHA/487-601             ...............dqsvctptpsgtyfstscmqnafas---------..-----.-..------.....S..G..Q......C........G..AN.YGVLCEWMN.G..DNTSVNQVIG.LLD........GS........NV.TSN........-K..L.SL....PA..G..S.SistvtggS..GS..TG.....A..QT...GAVSSTVYGFITNSLMVNLSQQPGQTP--pk.
Q5ZS33_LEGPH/485-589                 ........................................FDTGTGLDK..SSFDP.T..QLTKPF.....G..K..T......C........Q..DP.YSLLCTWFQ.N..KSDKLIQIQS.LID........GV........PA.LGQ........DG..V.KQ....PD..L..S.D.......N..PQ..RQ.....S..VS...GPLSSTVYGFVNNSMMVQLPGQPGIKPLT...
A0A0W0WMQ0_9GAMM/467-572             .......................................t-DTDTGLANpgSGFDA.S..KALGAF.....N..N.gQ......C........V..KE.YADLCIWLG.K..NVAPVSQVIS.LIN........GS........GI.LTA........-P..L.PT....PS..F..S.S.......T..GT..-T.....A..KA...GPASSTVFGFITNSSLVSLPGQPGLTP--pp.
A0A0W0VHR9_9GAMM/455-563             .......................................m-DEKTGLEK..SSFSP.G..KLLAAF.....T..E..AspgtynC........T..ST.YPDLCYWLN.K..DQNKVRAVVG.LIQ........GG........--.IGN.......iSL..V.SE....PQ..L..K.-.......N..LN..QN.....V..VK...GIESSTVYGFTTNSTIIRVPGQPGITPL-r..
A0A0W0YSV7_9GAMM/469-583             ........................................FDKNTGLDS..SSFDL.T..ELTSSF.....G..QggS......C........V..GT.YAKLCTWFG.G..NSSYLNAVQS.LINgaylssknGV........PI.ANN........NP..V.KA....PD..L..K.P.......N..PK..RE.....L..VS...GQESSTVYGFINNSVMVQLPGQPGLQPL-q..
A0A0W0TLP6_9GAMM/485-589             .......................................t-DTSSGLDS.nTSFDVvA..SLSSPF.....S.sQ..G......C........S..QQ.YAPLCAWFQ.G..SSTRIDQINA.LIS........G-........-A.IGN.......tPG..I.NM....PS..I..G.K.......N..NP..--.....V..TV...GPMADTVYGYINNASALQLPNQPGLAPLT...
A0A0W0VBN6_9GAMM/465-582             .......................................t-DSGTGLGE..SIFPT.IlpAVTSGF.....AsnN..T......Cs.....pgQ..SA.PNYLCQWMQ.G..DPAPINAVVG.LID........GS........-N.VGQ........ER..V.NF....PA..S..K.Dia...glN..TG..GQ.....D..VSaakGAASSTVYGFLHNSMMVQLPGQPGQNP--pq.
A0A0W0V2W0_9GAMM/472-574             ......................................pe--QGSGLSG..SSFNA.T..KLTDAF.....GsnN..T......C........Q..GT.RAALCTWFN.G..KSMVLQYLQG.SIT........G-........--.--P........TG..S.NI....PN..P..T.D......pS..SQ..IK.....I..VT...GTQSATVWGFINNSLTMKTPGQPGIDP--gf.
A0A0W0Y028_9GAMM/463-566             .......................................t-DSDSGLDS..SSADI.S..TMTNAF.....G..GdgT......C........K..GQ.YSELCQWYQ.G..DDKYVKHIAG.LID........GS........TV.LN-........SG..L.DV....PT..F..N.S.......-..IS..HK.....A..VT...GLGSSTTYGYISNASMVQLPGQPGI----vta
A0A0W0Z5I8_LEGSP/484-588             .......................................t-DKDTGLDS..SSFKI.E..NIIKSF.....GsnN..K......C........K..DP.YQDICEWMQ.T..NQAPMNNVVS.LIN........GA........SV.LSR........P-..Q.DP....PD..V..T.S.......-..LD..HK.....A..VS...GAGSSTVYGFIDNSLLVNLPGQPGLKP--pq.
A0A078KQA5_9GAMM/472-580             .......................................t-DTNTGLDS..SSIDV.S..SLLTPL.....S..S.pG......C........N..GT.FPSLCTWLS.K..YPSGLSAMQS.LTM........LI........DN.YNP........AA..AtPA....II..L..S.V.......I..PS..AS.....StpVL...GNGSATTVGFINNSVLITLPGQPGMTP--pa.
A0A0W0ZQ79_9GAMM/502-615             .......................................t-DSETGLEK..STFSA.S..AVTSPFvpsedG..K..Ti....tCgpgdmtnnN..KD.FSQLCKWFG.Q..DNTQVLEVHA.LIT........SD........PN.A--........--..K.NP....PS..L..G.N.......K..--..MT.....V..DS...GQSSSTVYGFLNNSFMMSNPEQPGVKPLT...
D3HP79_LEGLN/494-609                 vdpksgldgstfdaglimspfkvsdpstgastctaggnds---------..-----.-..------.....-..-..T......K........G..QD.FSDLCVWFN.Q..NATAVTQIKT.LLT........NT........--.LS-........-S..N.KV....PD..V..S.K.......S..L-..-P.....L..VS...GDNATTVMGFLNNGLKMQTPGQPGAAPV-n..
A0A0W1AF93_9GAMM/474-578             ........................................FDTNTGLNT..STFDP.T..NLVSSF.....TsnN..S......C........S..GQ.YSLLCTWFQ.G..DKTPLDKVQS.IIN........GA........S-.-LD........DM..V.SK....PS..M..K.D.......D..AK..RP.....V..VG...NQQSSTVYGFINNSVMVQLPGQPGIA---qpq
A0A0W0XZF2_9GAMM/456-564             .......................................t-DTNTGLEG..SQFDS.Q..IPLNAF.....SqnK..Q......C........S..GT.YAALCQWLG.G..NQTAIQNMVG.LIN........GS........TL.VGP........NNppL.SP....PT..F..G.N.......N..AA..QK.....A..QS...GVLSSTVYGFINNSVMVNLPGQPGLNP--pq.
A0A0W0THF1_9GAMM/481-589             .......................................v-DTGSGLNE..SSFDE.N..LPLTPF.....S..N.gS......C........V..GT.YATLCEWLD.G..DSSPIKAVIG.LIN........GS........TF.LPS........KE.iI.HS....PP..T..V.D.......P..NTsgLV.....A..IS...GPGSSTVNGFITNSILVNLPGQPGMTP--pq.
A0A098G030_9GAMM/492-604             ........................vsfngsktgmqgggpq---------..-----.-..------.....-..N..I......C........K..DPkYGPVCAWFGsN..ATAMLNQVQA.LID........GTfstedpknPG.VAQ........QG..D.AT....PApkFgkT.D.......I..QG..SS.....A..VT...SVGSASVNGFVTNSLMIQLPGQPGIAPL-q..
#=GC seq_cons                        .......................................o.DosTGLss..SoFDs.s..plhsuF.....u..p..s......C........s..us.YusLCsWhs.G..ssshlspVhu.LIs........Gs........ss.lus........ss..l.sh....Ps..h..s.s.......s..ss..tp.....s..lo...GssSSTVYGFINNShMVpLPGQPGlsP.....
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