GenomeNet

Database: Pfam
Entry: Dsl1_N
LinkDB: Dsl1_N
Original site: Dsl1_N 
#=GF ID   Dsl1_N
#=GF AC   PF11988.3
#=GF DE   Retrograde transport protein Dsl1 N terminal
#=GF AU   Mistry J, Gavin OL
#=GF SE   pdb_3etu
#=GF GA   25.00 25.00;
#=GF TC   43.40 43.20;
#=GF NC   20.30 20.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   19151722
#=GF RT   Structural characterization of Tip20p and Dsl1p, subunits of the
#=GF RT   Dsl1p vesicle tethering complex.
#=GF RA   Tripathi A, Ren Y, Jeffrey PD, Hughson FM;
#=GF RL   Nat Struct Mol Biol. 2009;16:114-123.
#=GF RN   [2]
#=GF RM   11493604
#=GF RT   The coatomer-interacting protein Dsl1p is required for
#=GF RT   Golgi-to-endoplasmic reticulum retrieval in yeast. 
#=GF RA   Andag U, Neumann T, Schmitt HD; 
#=GF RL   J Biol Chem 2001;276:39150-39160.
#=GF DR   INTERPRO; IPR021875;
#=GF CC   Dsl1 is a peripheral membrane protein required for transport
#=GF CC   between the Golgi and the endoplasmic reticulum [1]. It is
#=GF CC   localised to the ER membrane, and in vitro it specifically binds
#=GF CC   to coatomer, the major component of the protein coat of COPI
#=GF CC   vesicles [2]. It is comprised primarily of alpha helical bundles
#=GF CC   [1]. It complexes with another subunit of the Dsl1p complex
#=GF CC   called Tip20 which forms heterodimers by pairing the N termini
#=GF CC   of each protein [1].	A central disorganised region between the
#=GF CC   N and C termini of Dsl1 contains binding sites for coatomer [1].
#=GF CC   The C terminus of Dsl1 contains a binding site to the Sec39
#=GF CC   subunit of the Dsl1p complex [1].
#=GF SQ   25
#=GS C7GPA3_YEAS2/3-360   AC C7GPA3.1
#=GS H2AUI4_KAZAF/3-354   AC H2AUI4.1
#=GS A7TF57_VANPO/9-362   AC A7TF57.1
#=GS H0GM84_9SACH/3-360   AC H0GM84.1
#=GS G0WD68_NAUDC/8-396   AC G0WD68.1
#=GS Q6CUS2_KLULA/10-352  AC Q6CUS2.1
#=GS Q6CUS2_KLULA/10-352  DR PDB; 3K8P C; 333-352;
#=GS DSL1_YEAST/3-360     AC P53847.1
#=GS DSL1_YEAST/3-360     DR PDB; 3ETV A; 54-350;
#=GS DSL1_YEAST/3-360     DR PDB; 3ETU A; 37-355;
#=GS B3LPA1_YEAS1/3-360   AC B3LPA1.1
#=GS G8ZQK5_TORDC/15-366  AC G8ZQK5.1
#=GS E7LZD1_YEASV/3-360   AC E7LZD1.1
#=GS A6ZRI5_YEAS7/3-360   AC A6ZRI5.1
#=GS G0V593_NAUCC/10-369  AC G0V593.1
#=GS C8ZFX9_YEAS8/3-360   AC C8ZFX9.1
#=GS G8BQ21_TETPH/9-363   AC G8BQ21.1
#=GS Q6FNZ0_CANGA/1-351   AC Q6FNZ0.1
#=GS E7Q870_YEASB/3-360   AC E7Q870.1
#=GS G2WLK8_YEASK/3-360   AC G2WLK8.1
#=GS B2G488_ZYGRO/11-68   AC B2G488.1
#=GS C5DYW5_ZYGRC/11-364  AC C5DYW5.1
#=GS C5DK93_LACTC/21-365  AC C5DK93.1
#=GS E7QJM0_YEASZ/3-360   AC E7QJM0.1
#=GS Q752C3_ASHGO/43-390  AC Q752C3.1
#=GS H0H038_9SACH/3-360   AC H0H038.1
#=GS B5VQF2_YEAS6/1-270   AC B5VQF2.1
#=GS E7KT96_YEASL/3-360   AC E7KT96.1
C7GPA3_YEAS2/3-360              ..s-LFPNKGEIIRELLKD....PLIL-KNDSK..RSNgs...........elELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKM......R..N.NAAYL.KQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKITEN.SIQFTPTVEWGKD...KVH...IEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSADSQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYEN..EKNILVFSKS..SS..HGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLD.SPLKNLVSVINNKLTR......LVAKSE...vTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR.
H2AUI4_KAZAF/3-354              .pv--LPDRETLISLVEQN....LILK-NKNTI..DDP...............SLEMNKILEEESKLSEELRDLTKLKTISSLLKEVNVNFELLEFENCYYSLKSLRSKL......T..EnNSVFI.KQTYRFQRSTALYIDSLHSKLIDSIHEVITTKFWNITSN.TIKFNPKIKIGDD...DVQ...FDYTEFMSFAKSSFF..TKDTSSSEFWFLATMELGDYKENVRSKLNDINRNFIEFNNIIGSIKNLIYDDSVNVTYST..QDNILSFQKG..ES..NDY--LEKIIEKSQAIVNFLTETFLPNNLYVIVSEVGSLLSTELFKTAKSNASQLLRDRK.NPLIDLVRSINSSLIK......LSNEIK....SNWKYNGSDIDHLLNDEKVYINLLIDKTFDAEIKMLR.
A7TF57_VANPO/9-362              ..s-FVADKERLLQLLRND....PLLSLNDDVE..ITE...............KIDLEGLLKLDASLTEELHVLNSLKTIPSLILEFKANMEYLELENCYYSLQNLRKKL......K..E.NDTLV.RQNIRLQQSVATYVDSLHVQLVDKLFDLISNHFWNFKEH.TISHKDEIVYGKD...KVK...FDYETLLEFVNRDIF..PQNVLDFEHWLIKDMVMGDLQEIVRERLSTIVKSYILFDSIIHDVKENIFNDKGIFTYDE..DSKKLSLVDS..RS..KDLDLLTEKLVGFGKLADYLLSCISKRDVVILSSRIGPSIAKESHKLIKENISSILQEQS.TSIKNLILELNDKLLS......LSNATN....GVWNYSGNETEELLNDKQIYNNLLLDKIFEEQVNRIR.
H0GM84_9SACH/3-360              ..s-LFPNKGEIIRELLKD....PLIL-KNDSK..RSNgs...........elELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKM......R..N.NAAYL.KQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKITEN.SIQFTPTVEWGKD...KVH...IEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSADSQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYEN..EKNILVFSKS..SS..HGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLD.SPLKNLVSVINNKLTR......LVAKSE...vTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR.
G0WD68_NAUDC/8-396              ..a-LLSNKDELISSIKDD....LLLLQNKNNI..TTTgndaeddlnvskmdkTPDVNTILTKETQLATELHDLQQLKTISSLIMEFKTNFELFELENCFYSLQSLRKQIgtitinN..N.NPSFA.RQNYHFQRSVIVYIDSLHLDLISRIFEIITLKFWNITSE.SISFNPKLNVQTTdglDVE...IAYDSFISSIKNLYF..PNDIIDSEFWIISNVELNDLHESIRNKLQTIFKDYINLDGVSAMIKNAIFTNNKQFKYAN..--NKLSIISSltSM..NQTDFLTTTIESFQNIITFLNETLPLQDRNILLSKLGNTITTELLKFVKVNISKILNNENsNLMKDQTLKINTELITfakhftLSSSSHsglnNFKNYDGQQIIELLNNNRIYYNLLLDNSLYDQIKQMR.
Q6CUS2_KLULA/10-352             ..d-LLSDTSALSQAIEAD....PQFKSSDSVH.pKPN...............SKLLEEVLREDSDLTKDLAKYNQYKILSDLLKEFNTNYELNELENCYYSLQNIHKKF......K..D.VNIS-.GESFRFQQSVATYIDCLHLNVLERFKEV-SNMFYTISGN.EMMFKKTIEL--D...SVE...FNFDEMVELFENNFF..DHNMIDQTHWFIASTNLETYKDKEIVLLQEILDDTVKLNPLIKFFKEFVFDEKCIMVRAE..-PGKLTLATS..EY..NSL----DQIKSYQTLTTFIENDLSKHAKESVMIHFGNVLLTELLKIIRANP-ELLSNDK.EQTTEIISSIHDSLTK......ISEETE....--WAYDGFELNRILKDENIYTTLKFESMMQQRVIQIR.
#=GR Q6CUS2_KLULA/10-352  SS    ..X-XXXXXXXXXXXXXXX....XXXXXXXXXX.XXXX...............XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX......X..X.XXXX-.XXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXX.XXXXXXXXXX--X...XXX...XXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..-XXXXXXXXX..XX..XXX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXX.XXXXXXXXXXXXXXXX......XXXXXX....--XXXXXXXXXXXXXXX--HHHHHHHHHHHHHHHHHH.
DSL1_YEAST/3-360                ..s-LFPNKGEIIRELLKD....PLIL-KNDSK..RSNgs...........elELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKM......R..N.NAAYL.KQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKITEN.SIQFTPTVEWGKD...KVH...IEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSADSQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYEN..EKNILVFSKS..SS..HGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLD.SPLKNLVSVINNKLTR......LVAKSE...vTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR.
#=GR DSL1_YEAST/3-360     SS    ..X-XXXXXXXXXXXXXXX....XXXX-XXXXX..XXXXX...........XXXX-HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHH......H..H.-CCHH.CS-HHHHHHHHHHHHHHHHHHHHHHHHHHHCTTEEE-SS.EEEE-SEEEETTT...TEE...EEHHHHHHHHHHHH-..CCCS--TTSHHHHT-SSHHHHHHHHHHHHHHHHHHTS-HHHHHHHHCCTT-TTEEEEEET..TTTEEEEEE-..XX..XXXX-HHHHHHHHHHHHHHHHHTS-HHHHHHHHHHHHHHHHHHHHHHHHHTHHHHTSSTT.-CHHHHHHHHHHHHHH......HHHHHT...-SS----SHHHHHHCH-HHHHHHHHHHHHHHH-XXXXX.
B3LPA1_YEAS1/3-360              ..s-LFPNKGEIIRELLKD....PLIL-KNDSK..RSNgs...........elELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKM......R..N.NAAYL.KQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKITEN.SIQFTPTVEWGKD...KVH...IEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSADSQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYEN..EKNILVFSKS..SS..HGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLD.SPLKNLVSVINNKLTR......LVAKSE...vTNWTHSGKEIQDLLMNKRLYYNLLLDKVLESHISEIR.
G8ZQK5_TORDC/15-366             ..k-ILADRNGILHQLEDD....PVLI-NDELR..EPS...............KIDTDAILKREMGLSRELREYTALKTVPSLVLEFKTNLHLLEFENSFYSLQTLRKKL......R..D.FSEIL.SQSYGLQRSVATYVDNMHLDLVNSLYSILNDGFWKIGSD.FVSFQEKVAFGND...RVD...IDYVDFMASMVSLYF..PQGHLDPKSWIISDMILGTMQETVRAKLDFILKEYVKLSGVTNLIKSCIFAQSSEALLED..NNKTLKFRQS..SK..KGDEKFKETLSSFKNVLQFLTETVVSQDKKILAERLGPSISTELMKSIKANASIIFRPEN.THLRDESLAINLILKD......LSENSD....-IWSYNGSELERLFSNSDIPTNLQVDKILQDQLTELR.
E7LZD1_YEASV/3-360              ..s-LFPNKGEIIRELLKD....PLIL-KNDSK..RSNgs...........elELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKM......R..N.NAAYL.KQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKITEN.SIQFTPTVEWGKD...KVH...IEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSADSQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYEN..EKNILVFSKS..SS..HGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLD.SPLKNLVSVINNKLTR......LVAKSE...vTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR.
A6ZRI5_YEAS7/3-360              ..s-LFPNKGEIIRELLKD....PLIL-KNDSK..RSNgs...........elELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKM......R..N.NAAYL.KQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKITEN.SIQFTPTVEWGKD...KVH...IEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSADSQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYEN..EKNILVFSKS..SS..HGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLD.SPLKNLVSVINNKLTR......LVAKSE...vTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR.
G0V593_NAUCC/10-369             ..s-ILGNRDALIQSIEQNletpPLTATHDGNS..STQ...............ELNRGQLMMKEEQLSSQLHDLNNLKILSGLLIEFKTNFELLELENCFYSLQSIRKRI......NgnN.NSSFL.KQSFHFQRSVAVYVDTMHSTLIDKIFEIITTKFWQINDTgSIAFHKKITYGPE...DID...LEYESFIDFVKQQYF..PQNVLDSQLWIISDMDINDLQENVRGKLQTILKSYIHLNVVIDRIKKSIFTKGKMFDYEL..--GKLLFKDV..SNitDNQSLLQETIASFTSLVRFFQDILIEDDCITVLTSLGNVISNELTKLVKQNASVIL-NDN.SPLKDRIIEVSKSLVK......LADRTK....NQWHFNDSEILNILNNEQIYFNLMLDKKFNEALEYMR.
C8ZFX9_YEAS8/3-360              ..s-LFPNKGEIIRELLKD....PLIL-KNDSK..RSNgs...........elELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKM......R..N.NAAYL.KQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKITEN.SIQFTPTVEWGKD...KVH...IEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSADSQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYEN..EKNILVFSKS..SS..HGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLD.SPLKNLVSVINNKLTR......LVAKSE...vTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR.
G8BQ21_TETPH/9-363              svl----NEQSIKESLLQD....PLLFRNKSGDsvDSNs............neLLSFESVMNKDTALVAELHDLNSLKQISDLILEFNANWEYIEVENCYYSLLNLRKKL......K..Q.NDTVLaKQNIRFQQSVITYVESLHLKLIEKVSDLLTEKFWNITSN.SVVYNASVEL--N...NVK...FEYKPFLEFLSNELIieNDNILDLNNWFIKDMSLGELHNMVRNKMKIILNDYLHFELLLNKLKEALFNSNMKFDYDV..NNRKLSWEE-..NY..HDV-KSKDKLESLTNIVNYMNTELSELNS-KLIEKLSPLVANEFTKLVKGNISEIVQNEN.LS--TTVLTLNESINN......LKSFTQ...tASWYFDTAVINDLLKSKEVYNNLILDQILESHLEQLR.
Q6FNZ0_CANGA/1-351              ..m-TYADKDHVITELLKD....PVYLSRHNSL..ATH...............PKDENDLYALETKLEEELHDLKDLKIVSSLVKETQVNLDLMELENCYYSLYNLSKKL......K..S.SRSFL.KQSLHFQRSVAVHVDELRIKLLSTIYDILATKFWSISES.SFEFHPDIKWKEE...EFM...MKYEEFKSFVSKSFF..PDNAINNSHWLITDIIHSEEQERMRNKLKDIYINYIDFASLTKAVKDALFSDEYEFEWSD.nNYTKLLITKR..--..-GALCIQKRIESFNNLLSFLEKGISNSDKFKLLTNLGKAIGIEFLRFVKSNATGIIDKNA.NSIKQQTLLLNDRLKT......ISEQSG....-AWNFDSDQISKLLNDEILYKSLLLDGVLGRAISDVR.
E7Q870_YEASB/3-360              ..s-LFPNKGEIIRELLKD....PLIL-KNDSK..RSNgs...........elELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKM......R..N.NAAYL.KQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKITEN.SIQFTPTVEWGKD...KVH...IEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSADSQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYEN..EKNILVFSKS..SS..HGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLD.SPLKNLVSVINNKLTR......LVAKSE...vTNWTHSGKEIQDLLMNKXLYYNLLLDKVLESHISEIR.
G2WLK8_YEASK/3-360              ..s-LFPNKGEIVRELLKD....PLIL-KNDSK..RSNgs...........elELDSSDLLEREAVLANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKM......R..N.NAAYL.KQSFNFQQSISTYVDTLHLELVTTLYKILTNGFWKIAEN.SIQFTPTVEWGKD...KVH...IEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSADSQEQVRAKLNTIMKEYMNLSSIVSMIKNSIFISGKEISYEN..KTNILIFSKS..SS..HGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLD.SPLKNLVSVINNKLTR......LVAKSE...vTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR.
B2G488_ZYGRO/11-68              gll----SKAEILESLGKD....PLLVNEKESK..SDNkd...........dtPVDFEGILKRESSLNQELHDLASLR--------------------------------......-..-.-----.---------------------------------------.-------------...---...---------------..------------------------------------------------------------..----------..--..------------------------------------------------------------.----------------......------....-------------------------------------s
C5DYW5_ZYGRC/11-364             gll----SKAEILESLGKD....PLLVNEKESK..SDNkd...........dtPVDFEGILKRESSLNQELHDLASLRSISGLIMEFKANFELLELENCYYSLQNLRKKL......R..D.TSSLT.KQSFSFQQSVFSHVDTMHLQLVGKLYEIISQWFWQVNGD.SITFKRLVELGED...SET...MEYVPFITFVEQQYY..PDGFLDPDLWVIRHMKVGSSQDTVVENLNSILRDYLNSNLMIETIKRFLFAKGGKITWEDlgNTQKLHFKQS..--..-GTDKVGERISNILNVVSFLNEGITPHDKHALAEKLGPLLANDLLQSVRSNAYSVLHSSD.SPLREEVSLVNEKLKF......LSNDTR....--WNYQSNDVEDLLNDDQVHKNLLLDGVFENYALKIR.
C5DK93_LACTC/21-365             ..r-ILNDQDAILAGIESD....PNLKMEGSAR..REE...............PSDVQAILNQDVQLSKKLGALKELNLVANLIDEFKANFELWELENCYYSLQNLHKRL......E..K.VDMSL.-FPIQFQGLLKVHIDSLHVDLLSRIDKVMRQ-FWDISAR.SVTFNQKIAVDRD...DVL...LEYDSFSLFLKSCFF..SQDHFEPTSWFVATMNMGDAKDKVTNLLATAFNEWVRLQTVQEKLKQFLFSANVCLSLKG..----CTLGAS..EN..PGN--LDDTLKSFEALVMFMKDVTTAEDTAVILAKLGNTLLTEIVKFVKQNSSHLFAPGT.NY-KNSVVSLNTMLTE......LSHKGG....KSWQYAGRELDNLINDDSVINNLMLDKLLQEQISAIR.
E7QJM0_YEASZ/3-360              ..s-LFPNKGEIIRELLKD....PLIL-KNDSK..RSNgs...........elELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKM......R..N.NAAYL.KQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKITEN.SIQFTPTVEWGKD...KVH...IEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSADSQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYEN..EKNILVFSKS..SS..HGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLD.SPLKNLVSVINNKLTR......LVAKSE...vTNWTHSGKEIQDLLMNKXLYYNLLLDKVLESHISEIR.
Q752C3_ASHGO/43-390             ...ELLGNPMQVLAAIEDD....PSLWLDSSEK..KPN...............HLALQELKQRDVEVTKTLQQHLRLKIVADLLIKYNSEIQCAEFTAAFETLRQCVQKA......K..S.ADVS-.AHGVRFEQAFNTYLSGLHAVFVRKLQGLLEE-VWHIHDD.GFSFQQQVSEKLD...DARehnFDYDTLVDMFNSCFL..KDGDIDERSWFFKNISMPDVRDDVKQCVNSTYNNYIKLSQVKENLKGFLFSDSLRISCSG..--TRLHVDQ-..--..-GCETPAAKVESYVVLADYLLNVLSPVASNQILMTLGGAIVTEATKLLKQHSKELLSKEA.NQ-KKDLAHFNDTLVK......LSSRKG....SSWTYNGNALDKLLNDPETFATLMFEQHVHLHLLKLR.
H0H038_9SACH/3-360              ..s-LFDDKEEIIRELRKD....PLIIKDDNQM..VNGs............glELDSNDLLQQEALLANELNTLDNLKTLSILIIEVKTNLDLLELRNCYYSLQSLRKKM......R..N.NTAFI.KQSFNFQQSISSYVDTLHLELVTALYTILTGGFWKITEN.TIHFTPTVKWGKD...KVD...IGYDTFMNFLVQQYF..PQGVLDNQAWIISDMCNADSQEQVRTKLYAILKDYMHLSSVVNMIKSSIFIPGRQISYDR..EEGMLIFSKS..SS..HGQNNVSTALASFETVCDFILDRLALRDMKTLSFELGHLFNTEFTKFVKNNASIILDSLD.SPLKVLVSATNNKLIR......LASESK...vTNWSYSGKEIQDLLMNKQLYYNLLLDKILESHINDIR.
B5VQF2_YEAS6/1-270              ...----------------....----------..---...............--------------------------------------------------------M......R..N.NAAYL.KQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKITEN.SIQFTPTVEWGKD...KVH...IEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSADSQEQVRAKLNTIMKEYMNLSSIVSMIKNSIFISGKEISYEN..EKNILVFSKS..SS..HGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLD.SPLKNLVSVINNKLTR......LVAKSE...vTNWTHSGKEIQDLLMNKRLYYNLLLDKVLESHISEIR.
E7KT96_YEASL/3-360              ..s-LFPNKGEIIRELLKD....PLIL-KNDSK..RSNgs...........elELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKM......R..N.NAAYL.KQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKITEN.SIQFTPTVEWGKD...KVH...IEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSADSQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYEN..EKNILVFSKS..SS..HGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLD.SPLKNLVSVINNKLTR......LVAKSE...vTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR.
#=GC SS_cons                    ..X-XXXXXXXXXXXXXXX....XXXX-XXXXX..XXXXX...........XXXX-HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHH......H..H.-CCHH.CS-HHHHHHHHHHHHHHHHHHHHHHHHHHHCTTEEE-SS.EEEE-SEEEETTT...TEE...EEHHHHHHHHHHHH-..CCCS--TTSHHHHT-SSHHHHHHHHHHHHHHHHHHTS-HHHHHHHHCCTT-TTEEEEEET..TTTEEEEEE-..XX..XXXX-HHHHHHHHHHHHHHHHHTS-HHHHHHHHHHHHHHHHHHHHHHHHHTHHHHTSSTT.-CHHHHHHHHHHHHHH......HHHHHT...-SS----SHHHHHHCH-HHHHHHHHHHHHHHHHHHHHH.
#=GC seq_cons                   ..u.LhsNKsEIIcpLhKD....PLll.cs-o+..coNt............phcLDss-LLpREuhLusELphLssLKTh.sLIcEhKTNlplLELENCYYSLQSLRKKh......R..N.NuuaL.KQSFsFQQSluTYVDTLHL-LVooLYcILTstFW+ITEN.SIpFsPoVEaG+D...+V+...IEYDTFM-FVsQQYF..PcGsLDspuWFIhDMs.uDuQEpVRuKLNTIhK-YhsLSpllshIKsuIFhsG+cISYEs..ppshLlFuKS..SS..+GpcslossLsSFcuVsDFhLDsLuh+D++oLuhcLGPLhsTEFTKFVKsNASlILcshc.SPLKsLVSsINsKLs+......Lsu+Sc...sosWoauGcEIpDLLhNKplYaNLLLDKlLEuHIo-IR.
//
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