GenomeNet

Database: Pfam
Entry: Dsl1_N
LinkDB: Dsl1_N
Original site: Dsl1_N 
#=GF ID   Dsl1_N
#=GF AC   PF11988.5
#=GF DE   Retrograde transport protein Dsl1 N terminal
#=GF AU   Mistry J, Gavin OL
#=GF SE   pdb_3etu
#=GF GA   25.00 25.00;
#=GF TC   54.50 50.10;
#=GF NC   19.70 19.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   19151722
#=GF RT   Structural characterization of Tip20p and Dsl1p, subunits of the
#=GF RT   Dsl1p vesicle tethering complex.
#=GF RA   Tripathi A, Ren Y, Jeffrey PD, Hughson FM;
#=GF RL   Nat Struct Mol Biol. 2009;16:114-123.
#=GF RN   [2]
#=GF RM   11493604
#=GF RT   The coatomer-interacting protein Dsl1p is required for
#=GF RT   Golgi-to-endoplasmic reticulum retrieval in yeast. 
#=GF RA   Andag U, Neumann T, Schmitt HD; 
#=GF RL   J Biol Chem 2001;276:39150-39160.
#=GF DR   INTERPRO; IPR021875;
#=GF CC   Dsl1 is a peripheral membrane protein required for transport
#=GF CC   between the Golgi and the endoplasmic reticulum [1]. It is
#=GF CC   localised to the ER membrane, and in vitro it specifically binds
#=GF CC   to coatomer, the major component of the protein coat of COPI
#=GF CC   vesicles [2]. It is comprised primarily of alpha helical bundles
#=GF CC   [1]. It complexes with another subunit of the Dsl1p complex
#=GF CC   called Tip20 which forms heterodimers by pairing the N termini
#=GF CC   of each protein [1].  A central disorganised region between the
#=GF CC   N and C termini of Dsl1 contains binding sites for coatomer [1].
#=GF CC   The C terminus of Dsl1 contains a binding site to the Sec39
#=GF CC   subunit of the Dsl1p complex [1].
#=GF SQ   21
#=GS DSL1_YEAST/5-360     AC P53847.1
#=GS DSL1_YEAST/5-360     DR PDB; 3ETU A; 54-355;
#=GS DSL1_YEAST/5-360     DR PDB; 3ETV A; 54-350;
#=GS E7KT96_YEASL/5-360   AC E7KT96.1
#=GS Q6CUS2_KLULA/12-352  AC Q6CUS2.1
#=GS Q6CUS2_KLULA/12-352  DR PDB; 3K8P C; 333-352;
#=GS G0V593_NAUCC/12-369  AC G0V593.1
#=GS J7S867_KAZNA/6-376   AC J7S867.1
#=GS G8BQ21_TETPH/10-363  AC G8BQ21.1
#=GS J8Q396_SACAR/5-358   AC J8Q396.1
#=GS S6EM73_ZYGB2/12-362  AC S6EM73.1
#=GS G8ZQK5_TORDC/17-366  AC G8ZQK5.1
#=GS Q6FNZ0_CANGA/3-351   AC Q6FNZ0.1
#=GS C5DYW5_ZYGRC/12-364  AC C5DYW5.1
#=GS Q752C3_ASHGO/45-390  AC Q752C3.1
#=GS A7TF57_VANPO/11-362  AC A7TF57.1
#=GS I2GW53_TETBL/22-390  AC I2GW53.1
#=GS K0KHW4_WICCF/11-177  AC K0KHW4.1
#=GS G0WD68_NAUDC/10-396  AC G0WD68.1
#=GS H2AUI4_KAZAF/5-354   AC H2AUI4.1
#=GS C5DK93_LACTC/23-365  AC C5DK93.1
#=GS E7Q870_YEASB/5-360   AC E7Q870.1
#=GS E7QJM0_YEASZ/5-360   AC E7QJM0.1
#=GS E7LZD1_YEASV/5-360   AC E7LZD1.1
DSL1_YEAST/5-360                ...........f-PNKGEIIRELLKD....PLILKNDSKRSn............gSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR............
#=GR DSL1_YEAST/5-360     SS    ...........X-XXXXXXXXXXXXX....XXXXXXXHCCHH............HHHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHH-CCHHCS-HHHHHHHHHHHHHHHHHHH......HHCTTEEE-SSEEEE-SEEEETTTTEEEEHHHHHHHHHHHH-........S.HHHT-SSHHH...HHHHHHHHHHHHTS-HHHHHHHH..TT-TTEEEEEETTTTEEEE.E--------HHHHHHHHHHHHHHHHHTS-HHHHHHHHHHHHHHHHHHHHHHH........SSTT-CHHHHHHHHHHHHHHHHHHHT-SS----SHHHHHHCHXHHHHHHHHHHHHHHHXXXXXX.XXXXXXXXXXXXXXXXX.........XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX............
E7KT96_YEASL/5-360              ...........f-PNKGEIIRELLKD....PLILKNDSKRSn............gSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR............
Q6CUS2_KLULA/12-352             ............LSDTSALSQAIEAD....PQFKSSDSVHP..............KPNSKLLEEVLREDSDLTKDLAKYNQYKILSDLLKEFNTNYELNELENCYYSLQNIHKKFK......-DVNISGESFRFQQSVATYIDCLHLNVLERFKEV-SNMFYTI........S.GNEMMFKKTI...--ELDSVEFNFDEMVELFENNFF..DHNMIDQTHWFIASTNLET.YKDKEIVLLQEILDDTVKLNPLIKFFKEFVFDEKCIMVRAE-----PGKLTL........ATSEYNSLDQIKSYQTLTTFIENDLSKHAKESVMIHFGNVLLTELLKIIRANPELLSNDKEQT-.TEIISSIHDSLTKISEE..........--TEWAYDGFELNRILKDENIYTTLKFESMMQQRVIQIR............
#=GR Q6CUS2_KLULA/12-352  SS    ............XXXXXXXXXXXXXX....XXXXXXXXXXX..............XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX......-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXX........X.XXXXXXXXXX...--XXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----XXXXXX........XXXXXXXXXXXXXXXXXXXXXXXXXXXXX--HHHHHHHHHHHHHHHHHHXXXXXXXXXXXXXX-.XXXXXXXXXXXXXXXXX..........--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX............
G0V593_NAUCC/12-369             ............LGNRDALIQSIEQNletpPLTATHDGNSS..............-TQELNRGQLMMKEEQLSSQLHDLNNLKILSGLLIEFKTNFELLELENCFYSLQSIRKRINg....nNNSSFLKQSFHFQRSVAVYVDTMHSTLIDKIFEIITTKFWQI........NdTGSIAFHKKI...TYGPEDIDLEYESFIDFVKQQYF..PQNVLDSQLWIISDMDIND.LQENVRGKLQTILKSYIHLNVVIDRIKKSIFTKGKMFDYELGKLLFKDVSNI........TDNQSLLQETIASFTSLVRFFQDILIEDDCITVLTSLGNVISNELTKLVKQNASVILND-NSPL.KDRIIEVSKSLVKLADR..........TKNQWHFNDSEILNILNNEQIYFNLMLDKKFNEALEYMR............
J7S867_KAZNA/6-376              ...........a-PEREEVLLSVERD....PIFQGENGADVaa.........snyTQLTERIREVVAQEAQLGSMLHDLSVLKTFGDLLNEFNTNLAKSLFQDCYRALQTLRQKLN.....tSRDCFVKQPLHFQRSLMNYIDELHLTLIERIYEIISTDFWSV........T.HDSITFHNKI..vCSEGSGGQFEYRQFMELVKKLFFwdDGEISTEDTWFLKDMDLNNpSSNIVRNKLSEISKNYLELNEIVVNLKRGIFDNSIKFEFQAESCTLSFTKVKnaipnssgSYNKAALASVVESINALADFLMQCIDGNDLVIILSKLGPLLSNELLNFLRKNATVILRDSDPSI.REGIVLINNRFGVLASK..........SNGFWNHNRNDIEHLLNDKQLYINLLVDDAFAKTFKEIR............
G8BQ21_TETPH/10-363             ..........vl--NEQSIKESLLQD....PLLFRNKSGDSvd..........snSNELLSFESVMNKDTALVAELHDLNSLKQISDLILEFNANWEYIEVENCYYSLLNLRKKLK.....qNDTVLAKQNIRFQQSVITYVESLHLKLIEKVSDLLTEKFWNI........T.SNSVVYNASV...--ELNNVKFEYKPFLEFLSNELIieNDNILDLNNWFIKDMSLGE.LHNMVRNKMKIILNDYLHFELLLNKLKEALFNSNMKFDYDVNNR--KLSWEE........NYHDVKSKDKLESLTNIVNYMNTELSELNSK-LIEKLSPLVANEFTKLVKGNISEIVQNENL--.STTVLTLNESINNLKSF.........tQTASWYFDTAVINDLLKSKEVYNNLILDQILESHLEQLR............
J8Q396_SACAR/5-358              ...........s-HNKDEIIRELRKD....PLVIKSDNQKIn............sGELKLDSSELLRQEATLANELNTLDNLKALSTLIVEVKTNLDLLELENCFYSLQSLRTKMR......KNTAFLKQSFNFQQSVSSYVDTLHLELVNALHKILTTGFWKI........T.ENSIQFTPTV...KWGKNEVDIEYDTFMDFVVRQYF..PQSSLDNQAWIISDMGNAD.SQEQVRAKLNTILKDYINLTSVVNMIKCSIFIPGRQVSYEEEKNMLVFSQSS........LQNN--TSAALTSFETVCDFVLDRLSLRDKKTLSYELGHLFNTEFTKFVKNNASIILDSLDSPL.KKLVSVTNDKLIRLASE.........tGVTNWSYSGKEIQDLLMNKQLYYNLLLDKILESHIKDLR............
S6EM73_ZYGB2/12-362             ..........ll--NKDSVLASLKDD....PLLTGAKDELTn............nDPATLDYDAILRKDSRLSQQLHDLSSLRSVSGLIMEFKANFELLEFENCYYSLQSLRKKLR......DNAAINKQGVSFQQSVLAHTDAMHSQLVHKFYEIITQHFWQV........T.DESIAFEPIV...RLGVDSENLDYVSFMRFIEQQFY..PDGFLDANMWIIGDMRVGP.TQDAVISELNAIFHDFLNFRMIIEVIKKFLFSKAKQIVFERGNC--VKLSLH........RGGEDNVSDRIANINNVACFLCEGISVRDIDTFAKKLGPVLATELIQTIKSNPYTVLPSSHSQI.RADVAMANQNLRQLAKK..........--SNWTYHGSDVENLLNDNQVQNSLLLDGIFERYALKIR............
G8ZQK5_TORDC/17-366             ............LADRNGILHQLEDD....PVLINDELREP..............--SKIDTDAILKREMGLSRELREYTALKTVPSLVLEFKTNLHLLEFENSFYSLQTLRKKLR......DFSEILSQSYGLQRSVATYVDNMHLDLVNSLYSILNDGFWKI........G.SDFVSFQEKV...AFGNDRVDIDYVDFMASMVSLYF..PQGHLDPKSWIISDMILGT.MQETVRAKLDFILKEYVKLSGVTNLIKSCIFAQSSEALLEDNNKTLKFRQSS........KKGDEKFKETLSSFKNVLQFLTETVVSQDKKILAERLGPSISTELMKSIKANASIIFRPENTHL.RDESLAINLILKDLSEN..........-SDIWSYNGSELERLFSNSDIPTNLQVDKILQDQLTELR............
Q6FNZ0_CANGA/3-351              ...........y-ADKDHVITELLKD....PVYLSRHNSLA..............-THPKDENDLYALETKLEEELHDLKDLKIVSSLVKETQVNLDLMELENCYYSLYNLSKKLK......SSRSFLKQSLHFQRSVAVHVDELRIKLLSTIYDILATKFWSI........S.ESSFEFHPDI...KWKEEEFMMKYEEFKSFVSKSFF..PDNAINNSHWLITDIIHSE.EQERMRNKLKDIYINYIDFASLTKAVKDALFSDEYEFEWSDNNY--TKLLIT........KRGALCIQKRIESFNNLLSFLEKGISNSDKFKLLTNLGKAIGIEFLRFVKSNATGIIDKNANSI.KQQTLLLNDRLKTISEQ..........-SGAWNFDSDQISKLLNDEILYKSLLLDGVLGRAISDVR............
C5DYW5_ZYGRC/12-364             ..........ll--SKAEILESLGKD....PLLVNEKESKSd...........nkDDTPVDFEGILKRESSLNQELHDLASLRSISGLIMEFKANFELLELENCYYSLQNLRKKLR......DTSSLTKQSFSFQQSVFSHVDTMHLQLVGKLYEIISQWFWQV........N.GDSITFKRLV...ELGEDSETMEYVPFITFVEQQYY..PDGFLDPDLWVIRHMKVGS.SQDTVVENLNSILRDYLNSNLMIETIKRFLFAKGGKITWEDLGNT-QKLHFK........QSGTDKVGERISNILNVVSFLNEGITPHDKHALAEKLGPLLANDLLQSVRSNAYSVLHSSDSPL.REEVSLVNEKLKFLSND..........--TRWNYQSNDVEDLLNDDQVHKNLLLDGVFENYALKIR............
Q752C3_ASHGO/45-390             ...........l-GNPMQVLAAIEDD....PSLWLDSSEKK..............-PNHLALQELKQRDVEVTKTLQQHLRLKIVADLLIKYNSEIQCAEFTAAFETLRQCVQKAK......-SADVSAHGVRFEQAFNTYLSGLHAVFVRKLQGLLEE-VWHI........H.DDGFSFQQQVsekLDDAREHNFDYDTLVDMFNSCFL..KDGDIDERSWFFKNISMPD.VRDDVKQCVNSTYNNYIKLSQVKENLKGFLFSDSLRISCS------GTRLHV........DQGCETPAAKVESYVVLADYLLNVLSPVASNQILMTLGGAIVTEATKLLKQHSKELLSKEANQ-.KKDLAHFNDTLVKLSSR..........KGSSWTYNGNALDKLLNDPETFATLMFEQHVHLHLLKLR............
A7TF57_VANPO/11-362             ...........v-ADKERLLQLLRND....PLLSLNDDVEI..............-TEKIDLEGLLKLDASLTEELHVLNSLKTIPSLILEFKANMEYLELENCYYSLQNLRKKLK......ENDTLVRQNIRLQQSVATYVDSLHVQLVDKLFDLISNHFWNF........K.EHTISHKDEI...VYGKDKVKFDYETLLEFVNRDIF..PQNVLDFEHWLIKDMVMGD.LQEIVRERLSTIVKSYILFDSIIHDVKENIFNDKGIFTYDEDSKKLSLVDSR........SKDLDLLTEKLVGFGKLADYLLSCISKRDVVILSSRIGPSIAKESHKLIKENISSILQEQSTSI.KNLILELNDKLLSLSNA..........TNGVWNYSGNETEELLNDKQIYNNLLLDKIFEEQVNRIR............
I2GW53_TETBL/22-390             ............LNNRDILVASIKND....IESTIEDSPTQppt.......iethIKAHIDPFVIQQEDTQLSNDLYELNKLKTITSLIMEFKTNYELMEYENCYYSLQNLRKKIH......ENEPILVKNYHLKQSLSSYADGLHVQLIEAIHSLVSKGFWKIptvsasdnQ.NVSIEFQKII...HWGNGHIEFEYEFFIDFLRDALF..PDSKFDLQNWLITELVSTD.LQQIVKDNMDSLFNEYIQFSTLVHVLKTGIMNRNYSIVLTGEASNIINLQTK........LNSKSSIQDYLYSLENIIEYLKNTLLERDSITIFNQIGNYFFNEIIKLIKSNTYIILEDDGNDIlKSQISKICNTLSFLSKR..........NTSIWKFDEDEITHLLNNRQLQSNLLVDKLFETKITTIR............
K0KHW4_WICCF/11-177             leslnekihqlv-------------D....PEVLNSQLNGS.............kTLDFNTISKLQQRDYEITQELQQLREFWIVSTLLKETEVNLDLFEFENVLYSLKNFEKKIK......-SDSFDTKLIILEKLQAEH-DRLYNLTIENIGTSWSK-LIEV........Q.ESSVTFNAEV...DIN--GNTVLYESVSDVIKSN--..-------------------.----------------------------------------------------........----------------------------------------------------------------.-----------------..........---------------------------------------dlqlkvpnsnii
G0WD68_NAUDC/10-396             ............LSNKDELISSIKDD....LLLLQNKNNITttgndaeddlnvskMDKTPDVNTILTKETQLATELHDLQQLKTISSLIMEFKTNFELFELENCFYSLQSLRKQIGtitinnNNPSFARQNYHFQRSVIVYIDSLHLDLISRIFEIITLKFWNI........T.SESISFNPKLnvqTTDGLDVEIAYDSFISSIKNLYF..PNDIIDSEFWIISNVELND.LHESIRNKLQTIFKDYINLDGVSAMIKNAIFTNNKQFKYANNKLSIISSLTS........MNQTDFLTTTIESFQNIITFLNETLPLQDRNILLSKLGNTITTELLKFVKVNISKILNNENSNLmKDQTLKINTELITFAKHftlsssshsgLNNFKNYDGQQIIELLNNNRIYYNLLLDNSLYDQIKQMR............
H2AUI4_KAZAF/5-354              ............LPDRETLISLVEQN....-LILKNKNTID..............-DPSLEMNKILEEESKLSEELRDLTKLKTISSLLKEVNVNFELLEFENCYYSLKSLRSKLT.....eNNSVFIKQTYRFQRSTALYIDSLHSKLIDSIHEVITTKFWNI........T.SNTIKFNPKI...KIGDDDVQFDYTEFMSFAKSSFF..TKDTSSSEFWFLATMELGD.YKENVRSKLNDINRNFIEFNNIIGSIKNLIYDDSVNVTYSTQDN--ILSFQK........GESNDYLEKIIEKSQAIVNFLTETFLPNNLYVIVSEVGSLLSTELFKTAKSNASQLLRDRKNPL.IDLVRSINSSLIKLSNE..........IKSNWKYNGSDIDHLLNDEKVYINLLIDKTFDAEIKMLR............
C5DK93_LACTC/23-365             ............LNDQDAILAGIESD....PNLKMEGSARR..............-EEPSDVQAILNQDVQLSKKLGALKELNLVANLIDEFKANFELWELENCYYSLQNLHKRLE......-KVDMSLFPIQFQGLLKVHIDSLHVDLLSRIDKVMRQ-FWDI........S.ARSVTFNQKI...AVDRDDVLLEYDSFSLFLKSCFF..SQDHFEPTSWFVATMNMGD.AKDKVTNLLATAFNEWVRLQTVQEKLKQFLFSANVCLSLK------GCTLGA........SENPGNLDDTLKSFEALVMFMKDVTTAEDTAVILAKLGNTLLTEIVKFVKQNSSHLFAPGTNY-.KNSVVSLNTMLTELSHK..........GGKSWQYAGRELDNLINDDSVINNLMLDKLLQEQISAIR............
E7Q870_YEASB/5-360              ...........f-PNKGEIIRELLKD....PLILKNDSKRSn............gSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKXLYYNLLLDKVLESHISEIR............
E7QJM0_YEASZ/5-360              ...........f-PNKGEIIRELLKD....PLILKNDSKRSn............gSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKXLYYNLLLDKVLESHISEIR............
E7LZD1_YEASV/5-360              ...........f-PNKGEIIRELLKD....PLILKNDSKRSn............gSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR............
#=GC SS_cons                    ............XXXXXXXXXXXXXX....XXXXXXXHCCHH............HHHHHHHHHHHHHHHTTXHHHHHHHHHHHHHHHHHXCCHHCSXHHHHHHHHHHHHHHHHHHH......HHCTTEEEXSSEEEEXSEEEETTTTEEEEHHHHHHHHHHHHX........S.HHHTXSSHHH...HHHHHHHHHHHHTSXHHHHHHHH..TTXTTEEEEEETTTTEEEE.EXXXXXXXXHHHHHHHHHHHHHHHHHTSXHHHHHHHHHHHHHHHHHHHHHHH........SSTTXCHHHHHHHHHHHHHHHHHHHTXSS--HHCHHHHHHCHHHHHHHHHHHHHHHHHXXXXX-.XXXXXXXXXXXXXXXXX..........--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX............
#=GC seq_cons                   ...........h.ss+spllppltcD....PLlhpscspcs...............ptplDhsslLp+EspLupELppLssLKolusLIhEhKoNh-llELENCYYSLQsLRKKl+......sssshlKQuapFQQSluoYlDoLHlpLlsplacIlostFWpI........o.psSIpFpspl...phGp-cVch-Y-oFh-FlpppaF..PcshlDsptWhItDMshuD..Q-pVRsKLsoIh+-YlpLspllphlKpsIFssutphsacsppp..shspsp........spuppplsshlpSapslssFhh-sls.cDppslh.cLGsllsTEhhKhlKsNuShILpstsssl.Ks.lshlNspLppLusc..........tsssWsasGp-IpcLLpscplYhNLLLDclhcpplpclR............
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