GenomeNet

Database: Pfam
Entry: Dsl1_N
LinkDB: Dsl1_N
Original site: Dsl1_N 
#=GF ID   Dsl1_N
#=GF AC   PF11988.4
#=GF DE   Retrograde transport protein Dsl1 N terminal
#=GF AU   Mistry J, Gavin OL
#=GF SE   pdb_3etu
#=GF GA   25.00 25.00;
#=GF TC   34.90 34.80;
#=GF NC   22.00 21.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   19151722
#=GF RT   Structural characterization of Tip20p and Dsl1p, subunits of the
#=GF RT   Dsl1p vesicle tethering complex.
#=GF RA   Tripathi A, Ren Y, Jeffrey PD, Hughson FM;
#=GF RL   Nat Struct Mol Biol. 2009;16:114-123.
#=GF RN   [2]
#=GF RM   11493604
#=GF RT   The coatomer-interacting protein Dsl1p is required for
#=GF RT   Golgi-to-endoplasmic reticulum retrieval in yeast. 
#=GF RA   Andag U, Neumann T, Schmitt HD; 
#=GF RL   J Biol Chem 2001;276:39150-39160.
#=GF DR   INTERPRO; IPR021875;
#=GF CC   Dsl1 is a peripheral membrane protein required for transport
#=GF CC   between the Golgi and the endoplasmic reticulum [1]. It is
#=GF CC   localised to the ER membrane, and in vitro it specifically binds
#=GF CC   to coatomer, the major component of the protein coat of COPI
#=GF CC   vesicles [2]. It is comprised primarily of alpha helical bundles
#=GF CC   [1]. It complexes with another subunit of the Dsl1p complex
#=GF CC   called Tip20 which forms heterodimers by pairing the N termini
#=GF CC   of each protein [1].  A central disorganised region between the
#=GF CC   N and C termini of Dsl1 contains binding sites for coatomer [1].
#=GF CC   The C terminus of Dsl1 contains a binding site to the Sec39
#=GF CC   subunit of the Dsl1p complex [1].
#=GF SQ   41
#=GS DSL1_YEAST/5-360        AC P53847.1
#=GS DSL1_YEAST/5-360        DR PDB; 3ETV A; 54-350;
#=GS DSL1_YEAST/5-360        DR PDB; 3ETU A; 37-355;
#=GS B3LPA1_YEAS1/5-360      AC B3LPA1.1
#=GS Q6CUS2_KLULA/12-352     AC Q6CUS2.1
#=GS Q6CUS2_KLULA/12-352     DR PDB; 3K8P C; 333-352;
#=GS J8Q396_SACAR/5-358      AC J8Q396.1
#=GS C7GPA3_YEAS2/5-360      AC C7GPA3.1
#=GS G8ZQK5_TORDC/17-366     AC G8ZQK5.1
#=GS H0H038_SACCK/5-360      AC H0H038.1
#=GS Q752C3_ASHGO/45-390     AC Q752C3.1
#=GS A0A024XWX6_YEASX/5-360  AC A0A024XWX6.1
#=GS C8ZFX9_YEAS8/5-360      AC C8ZFX9.1
#=GS A7TF57_VANPO/11-362     AC A7TF57.1
#=GS A6ZRI5_YEAS7/5-360      AC A6ZRI5.1
#=GS K0KHW4_WICCF/11-177     AC K0KHW4.1
#=GS H0GM84_SACCK/5-360      AC H0GM84.1
#=GS G0WD68_NAUDC/10-396     AC G0WD68.1
#=GS E7Q870_YEASB/5-360      AC E7Q870.1
#=GS H2AUI4_KAZAF/5-354      AC H2AUI4.1
#=GS B2G488_ZYGRO/12-68      AC B2G488.1
#=GS E7QJM0_YEASZ/5-360      AC E7QJM0.1
#=GS E7KT96_YEASL/5-360      AC E7KT96.1
#=GS G0V593_NAUCC/12-369     AC G0V593.1
#=GS J7S867_KAZNA/6-376      AC J7S867.1
#=GS W7PMD2_YEASX/5-360      AC W7PMD2.1
#=GS W7RF24_YEASX/5-360      AC W7RF24.1
#=GS A0A023ZFN9_YEASX/5-360  AC A0A023ZFN9.1
#=GS G8BQ21_TETPH/10-363     AC G8BQ21.1
#=GS S6EM73_ZYGB2/12-362     AC S6EM73.1
#=GS W0VUG0_ZYGBA/12-362     AC W0VUG0.1
#=GS G2WLK8_YEASK/5-360      AC G2WLK8.1
#=GS R9XAA9_ASHAC/21-366     AC R9XAA9.1
#=GS A0A024XL86_YEASX/5-360  AC A0A024XL86.1
#=GS Q6FNZ0_CANGA/3-351      AC Q6FNZ0.1
#=GS C5DYW5_ZYGRC/12-364     AC C5DYW5.1
#=GS N1NWY6_YEASC/5-360      AC N1NWY6.1
#=GS M9N469_ASHG1/45-390     AC M9N469.1
#=GS W0VJN8_ZYGBA/20-370     AC W0VJN8.1
#=GS I2GW53_TETBL/22-390     AC I2GW53.1
#=GS W0T6M4_KLUMA/14-354     AC W0T6M4.1
#=GS B5VQF2_YEAS6/1-270      AC B5VQF2.1
#=GS C5DK93_LACTC/23-365     AC C5DK93.1
#=GS E7LZD1_YEASV/5-360      AC E7LZD1.1
DSL1_YEAST/5-360                   ...........f-PNKGEIIRELLKD....PLILKNDSKRSn............gSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR............
#=GR DSL1_YEAST/5-360        SS    ...........X-XXXXXXXXXXXXX....XXXXXXXXXXXX............XXXXXX-HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHH......H-CCHHCS-HHHHHHHHHHHHHHHHHHHHHHHHHHHCTTEEE........-.SSEEEE-SEE...EETTTTEEEEHHHHHHHHHHHH-..CCCS--TTSHHHHT-SSHH.HHHHHHHHHHHHHHHHTS-HHHHHHHHCCTT-TTEEEEEETTTTEEEEEE-X........XXXXX-HHHHHHHHHHHHHHHHHTS-HHHHHHHHHHHHHHHHHHHHHHHHHTHHHHTSSTT-CH.HHHHHHHHHHHHHHHHH.........HT-SS----SHHHHHHCH-HHHHHHHHHHHHHHH-XXXXX............
B3LPA1_YEAS1/5-360                 ...........f-PNKGEIIRELLKD....PLILKNDSKRSn............gSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKRLYYNLLLDKVLESHISEIR............
Q6CUS2_KLULA/12-352                ............LSDTSALSQAIEAD....PQFKSSDSVHP..............KPNSKLLEEVLREDSDLTKDLAKYNQYKILSDLLKEFNTNYELNELENCYYSLQNIHKKFK......-DVNISGESFRFQQSVATYIDCLHLNVLERFKEV-SNMFYTI........S.GNEMMFKKTI...--ELDSVEFNFDEMVELFENNFF..DHNMIDQTHWFIASTNLET.YKDKEIVLLQEILDDTVKLNPLIKFFKEFVFDEKCIMVRAE-----PGKLTL........ATSEYNSLDQIKSYQTLTTFIENDLSKHAKESVMIHFGNVLLTELLKIIRANPELLSNDKEQT-.TEIISSIHDSLTKISEE..........--TEWAYDGFELNRILKDENIYTTLKFESMMQQRVIQIR............
#=GR Q6CUS2_KLULA/12-352     SS    ............XXXXXXXXXXXXXX....XXXXXXXXXXX..............XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX......-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXX........X.XXXXXXXXXX...--XXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----XXXXXX........XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-.XXXXXXXXXXXXXXXXX..........--XXXXXXXXXXXXXXXXX--HHHHHHHHHHHHHHHHHH............
J8Q396_SACAR/5-358                 ...........s-HNKDEIIRELRKD....PLVIKSDNQKIn............sGELKLDSSELLRQEATLANELNTLDNLKALSTLIVEVKTNLDLLELENCFYSLQSLRTKMR......KNTAFLKQSFNFQQSVSSYVDTLHLELVNALHKILTTGFWKI........T.ENSIQFTPTV...KWGKNEVDIEYDTFMDFVVRQYF..PQSSLDNQAWIISDMGNAD.SQEQVRAKLNTILKDYINLTSVVNMIKCSIFIPGRQVSYEEEKNMLVFSQSS........LQNN--TSAALTSFETVCDFVLDRLSLRDKKTLSYELGHLFNTEFTKFVKNNASIILDSLDSPL.KKLVSVTNDKLIRLASE.........tGVTNWSYSGKEIQDLLMNKQLYYNLLLDKILESHIKDLR............
C7GPA3_YEAS2/5-360                 ...........f-PNKGEIIRELLKD....PLILKNDSKRSn............gSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR............
G8ZQK5_TORDC/17-366                ............LADRNGILHQLEDD....PVLINDELREP..............--SKIDTDAILKREMGLSRELREYTALKTVPSLVLEFKTNLHLLEFENSFYSLQTLRKKLR......DFSEILSQSYGLQRSVATYVDNMHLDLVNSLYSILNDGFWKI........G.SDFVSFQEKV...AFGNDRVDIDYVDFMASMVSLYF..PQGHLDPKSWIISDMILGT.MQETVRAKLDFILKEYVKLSGVTNLIKSCIFAQSSEALLEDNNKTLKFRQSS........KKGDEKFKETLSSFKNVLQFLTETVVSQDKKILAERLGPSISTELMKSIKANASIIFRPENTHL.RDESLAINLILKDLSEN..........-SDIWSYNGSELERLFSNSDIPTNLQVDKILQDQLTELR............
H0H038_SACCK/5-360                 ...........f-DDKEEIIRELRKD....PLIIKDDNQMVn............gSGLELDSNDLLQQEALLANELNTLDNLKTLSILIIEVKTNLDLLELRNCYYSLQSLRKKMR......NNTAFIKQSFNFQQSISSYVDTLHLELVTALYTILTGGFWKI........T.ENTIHFTPTV...KWGKDKVDIGYDTFMNFLVQQYF..PQGVLDNQAWIISDMCNAD.SQEQVRTKLYAILKDYMHLSSVVNMIKSSIFIPGRQISYDREEGMLIFSKSS........SHGQNNVSTALASFETVCDFILDRLALRDMKTLSFELGHLFNTEFTKFVKNNASIILDSLDSPL.KVLVSATNNKLIRLASE.........sKVTNWSYSGKEIQDLLMNKQLYYNLLLDKILESHINDIR............
Q752C3_ASHGO/45-390                ...........l-GNPMQVLAAIEDD....PSLWLDSSEKK..............-PNHLALQELKQRDVEVTKTLQQHLRLKIVADLLIKYNSEIQCAEFTAAFETLRQCVQKAK......-SADVSAHGVRFEQAFNTYLSGLHAVFVRKLQGLLEE-VWHI........H.DDGFSFQQQVsekLDDAREHNFDYDTLVDMFNSCFL..KDGDIDERSWFFKNISMPD.VRDDVKQCVNSTYNNYIKLSQVKENLKGFLFSDSLRISCS------GTRLHV........DQGCETPAAKVESYVVLADYLLNVLSPVASNQILMTLGGAIVTEATKLLKQHSKELLSKEANQ-.KKDLAHFNDTLVKLSSR..........KGSSWTYNGNALDKLLNDPETFATLMFEQHVHLHLLKLR............
A0A024XWX6_YEASX/5-360             ...........f-PNKGEIIRELLKD....PLILKNDSKRSn............gSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR............
C8ZFX9_YEAS8/5-360                 ...........f-PNKGEIIRELLKD....PLILKNDSKRSn............gSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR............
A7TF57_VANPO/11-362                ...........v-ADKERLLQLLRND....PLLSLNDDVEI..............-TEKIDLEGLLKLDASLTEELHVLNSLKTIPSLILEFKANMEYLELENCYYSLQNLRKKLK......ENDTLVRQNIRLQQSVATYVDSLHVQLVDKLFDLISNHFWNF........K.EHTISHKDEI...VYGKDKVKFDYETLLEFVNRDIF..PQNVLDFEHWLIKDMVMGD.LQEIVRERLSTIVKSYILFDSIIHDVKENIFNDKGIFTYDEDSKKLSLVDSR........SKDLDLLTEKLVGFGKLADYLLSCISKRDVVILSSRIGPSIAKESHKLIKENISSILQEQSTSI.KNLILELNDKLLSLSNA..........TNGVWNYSGNETEELLNDKQIYNNLLLDKIFEEQVNRIR............
A6ZRI5_YEAS7/5-360                 ...........f-PNKGEIIRELLKD....PLILKNDSKRSn............gSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR............
K0KHW4_WICCF/11-177                leslnekihqlv-------------D....PEVLNSQLNGS.............kTLDFNTISKLQQRDYEITQELQQLREFWIVSTLLKETEVNLDLFEFENVLYSLKNFEKKIK......-SDSFDTKLIILEKLQAEH-DRLYNLTIENIGTSWSK-LIEV........Q.ESSVTFNAEV...DIN--GNTVLYESVSDVIKSN--..-------------------.----------------------------------------------------........----------------------------------------------------------------.-----------------..........---------------------------------------dlqlkvpnsnii
H0GM84_SACCK/5-360                 ...........f-PNKGEIIRELLKD....PLILKNDSKRSn............gSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR............
G0WD68_NAUDC/10-396                ............LSNKDELISSIKDD....LLLLQNKNNITttgndaeddlnvskMDKTPDVNTILTKETQLATELHDLQQLKTISSLIMEFKTNFELFELENCFYSLQSLRKQIGtitinnNNPSFARQNYHFQRSVIVYIDSLHLDLISRIFEIITLKFWNI........T.SESISFNPKLnvqTTDGLDVEIAYDSFISSIKNLYF..PNDIIDSEFWIISNVELND.LHESIRNKLQTIFKDYINLDGVSAMIKNAIFTNNKQFKYANNKLSIISSLTS........MNQTDFLTTTIESFQNIITFLNETLPLQDRNILLSKLGNTITTELLKFVKVNISKILNNENSNLmKDQTLKINTELITFAKHftlsssshsgLNNFKNYDGQQIIELLNNNRIYYNLLLDNSLYDQIKQMR............
E7Q870_YEASB/5-360                 ...........f-PNKGEIIRELLKD....PLILKNDSKRSn............gSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKXLYYNLLLDKVLESHISEIR............
H2AUI4_KAZAF/5-354                 ............LPDRETLISLVEQN....-LILKNKNTID..............-DPSLEMNKILEEESKLSEELRDLTKLKTISSLLKEVNVNFELLEFENCYYSLKSLRSKLT.....eNNSVFIKQTYRFQRSTALYIDSLHSKLIDSIHEVITTKFWNI........T.SNTIKFNPKI...KIGDDDVQFDYTEFMSFAKSSFF..TKDTSSSEFWFLATMELGD.YKENVRSKLNDINRNFIEFNNIIGSIKNLIYDDSVNVTYSTQDN--ILSFQK........GESNDYLEKIIEKSQAIVNFLTETFLPNNLYVIVSEVGSLLSTELFKTAKSNASQLLRDRKNPL.IDLVRSINSSLIKLSNE..........IKSNWKYNGSDIDHLLNDEKVYINLLIDKTFDAEIKMLR............
B2G488_ZYGRO/12-68                 ..........ll--SKAEILESLGKD....PLLVNEKESKSd...........nkDDTPVDFEGILKRESSLNQELHDLASLR---------------------------------......------------------------------------------........-.----------...-----------------------..-------------------.----------------------------------------------------........----------------------------------------------------------------.-----------------..........---------------------------------------s...........
E7QJM0_YEASZ/5-360                 ...........f-PNKGEIIRELLKD....PLILKNDSKRSn............gSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKXLYYNLLLDKVLESHISEIR............
E7KT96_YEASL/5-360                 ...........f-PNKGEIIRELLKD....PLILKNDSKRSn............gSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR............
G0V593_NAUCC/12-369                ............LGNRDALIQSIEQNletpPLTATHDGNSS..............-TQELNRGQLMMKEEQLSSQLHDLNNLKILSGLLIEFKTNFELLELENCFYSLQSIRKRINg....nNNSSFLKQSFHFQRSVAVYVDTMHSTLIDKIFEIITTKFWQI........NdTGSIAFHKKI...TYGPEDIDLEYESFIDFVKQQYF..PQNVLDSQLWIISDMDIND.LQENVRGKLQTILKSYIHLNVVIDRIKKSIFTKGKMFDYELGKLLFKDVSNI........TDNQSLLQETIASFTSLVRFFQDILIEDDCITVLTSLGNVISNELTKLVKQNASVILND-NSPL.KDRIIEVSKSLVKLADR..........TKNQWHFNDSEILNILNNEQIYFNLMLDKKFNEALEYMR............
J7S867_KAZNA/6-376                 ...........a-PEREEVLLSVERD....PIFQGENGADVaa.........snyTQLTERIREVVAQEAQLGSMLHDLSVLKTFGDLLNEFNTNLAKSLFQDCYRALQTLRQKLN.....tSRDCFVKQPLHFQRSLMNYIDELHLTLIERIYEIISTDFWSV........T.HDSITFHNKI..vCSEGSGGQFEYRQFMELVKKLFFwdDGEISTEDTWFLKDMDLNNpSSNIVRNKLSEISKNYLELNEIVVNLKRGIFDNSIKFEFQAESCTLSFTKVKnaipnssgSYNKAALASVVESINALADFLMQCIDGNDLVIILSKLGPLLSNELLNFLRKNATVILRDSDPSI.REGIVLINNRFGVLASK..........SNGFWNHNRNDIEHLLNDKQLYINLLVDDAFAKTFKEIR............
W7PMD2_YEASX/5-360                 ...........f-PNKGEIIRELLKD....PLILKNDSKRSn............gSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR............
W7RF24_YEASX/5-360                 ...........f-PNKGEIIRELLKD....PLILKNDSKRSn............gSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR............
A0A023ZFN9_YEASX/5-360             ...........f-PNKGEIIRELLKD....PLILKNDSKRSn............gSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR............
G8BQ21_TETPH/10-363                ..........vl--NEQSIKESLLQD....PLLFRNKSGDSvd..........snSNELLSFESVMNKDTALVAELHDLNSLKQISDLILEFNANWEYIEVENCYYSLLNLRKKLK.....qNDTVLAKQNIRFQQSVITYVESLHLKLIEKVSDLLTEKFWNI........T.SNSVVYNASV...--ELNNVKFEYKPFLEFLSNELIieNDNILDLNNWFIKDMSLGE.LHNMVRNKMKIILNDYLHFELLLNKLKEALFNSNMKFDYDVNNR--KLSWEE........NYHDVKSKDKLESLTNIVNYMNTELSELNSK-LIEKLSPLVANEFTKLVKGNISEIVQNENL--.STTVLTLNESINNLKSF.........tQTASWYFDTAVINDLLKSKEVYNNLILDQILESHLEQLR............
S6EM73_ZYGB2/12-362                ..........ll--NKDSVLASLKDD....PLLTGAKDELTn............nDPATLDYDAILRKDSRLSQQLHDLSSLRSVSGLIMEFKANFELLEFENCYYSLQSLRKKLR......DNAAINKQGVSFQQSVLAHTDAMHSQLVHKFYEIITQHFWQV........T.DESIAFEPIV...RLGVDSENLDYVSFMRFIEQQFY..PDGFLDANMWIIGDMRVGP.TQDAVISELNAIFHDFLNFRMIIEVIKKFLFSKAKQIVFERGNC--VKLSLH........RGGEDNVSDRIANINNVACFLCEGISVRDIDTFAKKLGPVLATELIQTIKSNPYTVLPSSHSQI.RADVAMANQNLRQLAKK..........--SNWTYHGSDVENLLNDNQVQNSLLLDGIFERYALKIR............
W0VUG0_ZYGBA/12-362                ..........ll--NKDSVLASLKDD....PLLTGAKDELTn............nDPATLDYDAILRKDSRLSQQLHDLSSLRSVSGLIMEFKANFELLEFENCYYSLQSLRKKLR......DNAAINKQGVSFQQSVLAHTDAMHSQLVHKFYEIITQHFWQV........T.DESIAFEPIV...RLGVDSENFDYVSFMRFIEQQFY..PDGFLDANMWIIGDMRVGP.TQDAVISELNAIFHDFLNFRMIIEVIKKFLFSKAKQIVFERGNC--VKLSLH........RGGEDNVSDRIANINNVACFLCEGISVRDIDTFAKKLGPVLATELIQTIKSNPYTVLPSSHSQI.RADVAMANQNLRQLAKK..........--SNWTYHGSDVENLLNDNQVQNSLLLDGIFERYALKIR............
G2WLK8_YEASK/5-360                 ...........f-PNKGEIVRELLKD....PLILKNDSKRSn............gSELELDSSDLLEREAVLANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVTTLYKILTNGFWKI........A.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSSIVSMIKNSIFISGKEISYENKTNILIFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR............
R9XAA9_ASHAC/21-366                ...........l-GNPMQVLAAIEDD....PGLWLDSSEKK..............-PNHLALQELKQRDAEVTRTLQQHLRLKVVSDLLIKVNSEIQCAEFTAAFETLRKCVQRAK......-SADAAAYGVRFEQAFNTYLSGLHSVFAKKLQDLLAR-VWCI........H.DDEFSFQRQVsvkLDDAQERSFDYDSLFDMFSSYFL..KDGDLDEQSWFFTSISMPD.VRDEVKQCVSSTYNNYIKLVQVKEKLRGFLFNDSLHLQSKD------TSLHV........VQSSDTSAAKVKSYATLANYLLNVLSPAASNQILTTLGSTIVTEATKLLKQHSKELLSAEAKQ-.KEELANFNDTLVKLSSR..........KGSTWAYNGNALGRLLNDPETYATLTFEQHVHLHLLKLR............
A0A024XL86_YEASX/5-360             ...........f-PNKGEIIRELLKD....PLILKNDSKRSn............gSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR............
Q6FNZ0_CANGA/3-351                 ...........y-ADKDHVITELLKD....PVYLSRHNSLA..............-THPKDENDLYALETKLEEELHDLKDLKIVSSLVKETQVNLDLMELENCYYSLYNLSKKLK......SSRSFLKQSLHFQRSVAVHVDELRIKLLSTIYDILATKFWSI........S.ESSFEFHPDI...KWKEEEFMMKYEEFKSFVSKSFF..PDNAINNSHWLITDIIHSE.EQERMRNKLKDIYINYIDFASLTKAVKDALFSDEYEFEWSDNNY--TKLLIT........KRGALCIQKRIESFNNLLSFLEKGISNSDKFKLLTNLGKAIGIEFLRFVKSNATGIIDKNANSI.KQQTLLLNDRLKTISEQ..........-SGAWNFDSDQISKLLNDEILYKSLLLDGVLGRAISDVR............
C5DYW5_ZYGRC/12-364                ..........ll--SKAEILESLGKD....PLLVNEKESKSd...........nkDDTPVDFEGILKRESSLNQELHDLASLRSISGLIMEFKANFELLELENCYYSLQNLRKKLR......DTSSLTKQSFSFQQSVFSHVDTMHLQLVGKLYEIISQWFWQV........N.GDSITFKRLV...ELGEDSETMEYVPFITFVEQQYY..PDGFLDPDLWVIRHMKVGS.SQDTVVENLNSILRDYLNSNLMIETIKRFLFAKGGKITWEDLGNT-QKLHFK........QSGTDKVGERISNILNVVSFLNEGITPHDKHALAEKLGPLLANDLLQSVRSNAYSVLHSSDSPL.REEVSLVNEKLKFLSND..........--TRWNYQSNDVEDLLNDDQVHKNLLLDGVFENYALKIR............
N1NWY6_YEASC/5-360                 ...........f-PNKGEIVRELLKD....PLILKNDSKRSn............gSELELDSSDLLEREAVLANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVTTLYKILTNGFWKI........A.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSSIVSMIKNSIFISGKEISYENKTNILIFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR............
M9N469_ASHG1/45-390                ...........l-GNPMQVLAAIEDD....PSLWLDSSEKK..............-PNHLALQELKQRDVEVTKTLQQHLRLKIVADLLIKYNSEIQCAEFTAAFETLRQCVQKAK......-SADVSAHGVRFEQAFNTYLSGLHAVFVRKLQGLLEE-VWHI........H.DDGFSFQQQVsekLDDAREHNFDYDSLVDMFSSCFV..KDGDIDERSWFFKNISMPD.VRDDVKQCVNSTYNNYIKLSQVKENLKGFLFSDSLRISCS------GTRLHV........DQGCETPAAKVESYVVLADYLLNVLSPVASNQILMTLGGAIVTEATKVLKQHSKELLSKEANQ-.KKDLAHFNDTLVKLSSR..........KGSSWTYNGNALDKLLNDPETFATLMFEQHVHLHLLKLR............
W0VJN8_ZYGBA/20-370                ..........ll--NKENVLASLKDD....PLLTGAQDEETn............kDPATLDYDAILRKESCLNQQLHDLSSLRSVSGLIMEFKANFELLEFENCYYSLQSLRKKLR......DNAAINKQGVSFQQSVLAHADAMHSQLVHKFYEIITQHFWQV........T.DESIAFEPIV...GLGDDSEDLDYVPFMSFIEQQFY..SDGFLDANLWIIGDMRAGP.TQDEVIFELNAIFHDYLNSRMIIEVIKKFLFSKAKQIVFERGSC--VKLKLH........RDGEDKVSDRIANINSVACFLCEGISVRDIDTFAKKLGPVLATELIQTVKSNPYTVLHSSHSQI.RADVAMANQNLRKLAKK..........--SNWTYHGSDVESLLNDNQVQNRLLLDGIFEQYALKIR............
I2GW53_TETBL/22-390                ............LNNRDILVASIKND....IESTIEDSPTQppt.......iethIKAHIDPFVIQQEDTQLSNDLYELNKLKTITSLIMEFKTNYELMEYENCYYSLQNLRKKIH......ENEPILVKNYHLKQSLSSYADGLHVQLIEAIHSLVSKGFWKIptvsasdnQ.NVSIEFQKII...HWGNGHIEFEYEFFIDFLRDALF..PDSKFDLQNWLITELVSTD.LQQIVKDNMDSLFNEYIQFSTLVHVLKTGIMNRNYSIVLTGEASNIINLQTK........LNSKSSIQDYLYSLENIIEYLKNTLLERDSITIFNQIGNYFFNEIIKLIKSNTYIILEDDGNDIlKSQISKICNTLSFLSKR..........NTSIWKFDEDEITHLLNNRQLQSNLLVDKLFETKITTIR............
W0T6M4_KLUMA/14-354                ............LNDTSRLFEAIESD....PQFKVSNTTDS..............KPDEAKIEEVLEADSELTKELARLNQLKILSDLIKEFNTNYEFNELENCYYSLQNLHKKLQ......-EVNISGESFMFQQSVARYVDDLHLKLLNRLREFLSK-FWSF........S.QEEVSFRKTI...--EIDSNLLQFDELINMFENTFL..NQKTIDQSNWFIASTNLDS.SKEQEITVLQDILDEYVKLNPLISMLKRFAFGEDCTLLVPDDKT-----LRL........KAEKCSPLKRVQSYELLVDFIRNDLSKHSLESIMTQFGNILLLELLKIIRKNPELLSNDKEAT-.TKVLSNIHEGLKNIAND..........--SNWFYDESDLNRILKDENIYTVLKVESMMQNLILKIR............
B5VQF2_YEAS6/1-270                 ............--------------....-----------..............-----------------------------------------------------------MR......NNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSSIVSMIKNSIFISGKEISYENEKNILVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKRLYYNLLLDKVLESHISEIR............
C5DK93_LACTC/23-365                ............LNDQDAILAGIESD....PNLKMEGSARR..............-EEPSDVQAILNQDVQLSKKLGALKELNLVANLIDEFKANFELWELENCYYSLQNLHKRLE......-KVDMSLFPIQFQGLLKVHIDSLHVDLLSRIDKVMRQ-FWDI........S.ARSVTFNQKI...AVDRDDVLLEYDSFSLFLKSCFF..SQDHFEPTSWFVATMNMGD.AKDKVTNLLATAFNEWVRLQTVQEKLKQFLFSANVCLSLK------GCTLGA........SENPGNLDDTLKSFEALVMFMKDVTTAEDTAVILAKLGNTLLTEIVKFVKQNSSHLFAPGTNY-.KNSVVSLNTMLTELSHK..........GGKSWQYAGRELDNLINDDSVINNLMLDKLLQEQISAIR............
E7LZD1_YEASV/5-360                 ...........f-PNKGEIIRELLKD....PLILKNDSKRSn............gSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR............
#=GC SS_cons                       ............XXXXXXXXXXXXXX....XXXXXXXXXXX..............XXXXXXHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTXHHHHHHHHHHHHHHHH......HXCCHHCSXHHHHHHHHHHHHHHHHHHHHHHHHHHHCTTEEE........X.SSEEEEXSEE...EETTTTEEEEHHHHHHHHHHHHX..CCCSXXTTSHHHHTXSSHH.HHHHHHHHHHHHHHHHTSXHHHHHHHHCCTTXTTEEEEEETTTTEEEEEEXX........XXXXXXHHHHHHHHHHHHHHHHHTSXHHHHHHHHHHHHHHHHHHHHHHHHHTHHHHTSSTTXCH.HHHHHHHHHHHHHHHHH.........HT-SSXXXXSHHHHHHCHXHHHHHHHHHHHHHHHHHHHHH............
#=GC seq_cons                      ...........h.sNKscllppLhcD....PLllpscop+os............tsphcLD.s-LLp+EuhLupELp.LssLKoh.sLIhEhKTNlplLELENCYYSLQSLRKKhR......sNuualKQSasFQQSluTYVDoLHLcLVssLYcILTstFWcI........T.-sSIpFsPpV...caGcDcVclEYDoFMDFlspQaF..PcGsLDspuWFIhDMssuD.oQEpVRsKLNoIhK-YhsLspllshIKsuIFhsu+cIoYEsppshllhopos........scGpcslossLsSFpsVsDFhh-sLuhRDpcTLuhcLGPlhsTEhTKhVKsNASlILcu.cSsL.KshVusINscLs+Lsu+..........psoNWoasGpEIpcLL.scplYhNLLLDKlLEs+IpcIR............
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