GenomeNet

Database: Pfam
Entry: Dsl1_N
LinkDB: Dsl1_N
Original site: Dsl1_N 
#=GF ID   Dsl1_N
#=GF AC   PF11988.6
#=GF DE   Retrograde transport protein Dsl1 N terminal
#=GF AU   Mistry J, Gavin OL
#=GF SE   pdb_3etu
#=GF GA   25.00 25.00;
#=GF TC   39.90 32.50;
#=GF NC   19.70 19.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   19151722
#=GF RT   Structural characterization of Tip20p and Dsl1p, subunits of the
#=GF RT   Dsl1p vesicle tethering complex.
#=GF RA   Tripathi A, Ren Y, Jeffrey PD, Hughson FM;
#=GF RL   Nat Struct Mol Biol. 2009;16:114-123.
#=GF RN   [2]
#=GF RM   11493604
#=GF RT   The coatomer-interacting protein Dsl1p is required for
#=GF RT   Golgi-to-endoplasmic reticulum retrieval in yeast. 
#=GF RA   Andag U, Neumann T, Schmitt HD; 
#=GF RL   J Biol Chem 2001;276:39150-39160.
#=GF DR   INTERPRO; IPR021875;
#=GF CC   Dsl1 is a peripheral membrane protein required for transport
#=GF CC   between the Golgi and the endoplasmic reticulum [1]. It is
#=GF CC   localised to the ER membrane, and in vitro it specifically binds
#=GF CC   to coatomer, the major component of the protein coat of COPI
#=GF CC   vesicles [2]. It is comprised primarily of alpha helical bundles
#=GF CC   [1]. It complexes with another subunit of the Dsl1p complex
#=GF CC   called Tip20 which forms heterodimers by pairing the N termini
#=GF CC   of each protein [1].  A central disorganised region between the
#=GF CC   N and C termini of Dsl1 contains binding sites for coatomer [1].
#=GF CC   The C terminus of Dsl1 contains a binding site to the Sec39
#=GF CC   subunit of the Dsl1p complex [1].
#=GF SQ   23
#=GS DSL1_YEAST/5-360         AC P53847.1
#=GS DSL1_YEAST/5-360         DR PDB; 3ETU A; 37-355;
#=GS DSL1_YEAST/5-360         DR PDB; 3ETV A; 54-350;
#=GS E7KT96_YEASL/5-360       AC E7KT96.1
#=GS Q6CUS2_KLULA/12-352      AC Q6CUS2.1
#=GS Q6CUS2_KLULA/12-352      DR PDB; 3K8P C; 333-352;
#=GS G0V593_NAUCC/12-369      AC G0V593.1
#=GS J7S867_KAZNA/6-376       AC J7S867.1
#=GS G8BQ21_TETPH/10-363      AC G8BQ21.1
#=GS J8Q396_SACAR/5-358       AC J8Q396.1
#=GS A0A0H5CJT4_CYBJA/13-171  AC A0A0H5CJT4.1
#=GS S6EM73_ZYGB2/12-362      AC S6EM73.1
#=GS G8ZQK5_TORDC/17-366      AC G8ZQK5.1
#=GS Q6FNZ0_CANGA/3-351       AC Q6FNZ0.1
#=GS A0A0A8L3N0_9SACH/12-352  AC A0A0A8L3N0.1
#=GS C5DYW5_ZYGRC/12-364      AC C5DYW5.1
#=GS Q752C3_ASHGO/45-390      AC Q752C3.1
#=GS A7TF57_VANPO/11-362      AC A7TF57.1
#=GS I2GW53_TETBL/22-390      AC I2GW53.1
#=GS K0KHW4_WICCF/11-177      AC K0KHW4.1
#=GS G0WD68_NAUDC/10-396      AC G0WD68.1
#=GS H2AUI4_KAZAF/5-354       AC H2AUI4.1
#=GS C5DK93_LACTC/23-365      AC C5DK93.1
#=GS E7Q870_YEASB/5-360       AC E7Q870.1
#=GS E7QJM0_YEASZ/5-360       AC E7QJM0.1
#=GS E7LZD1_YEASV/5-360       AC E7LZD1.1
DSL1_YEAST/5-360                    ..............f-PNKGEIIRELLKD....PLILKNDSKRSn............gSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR........................
#=GR DSL1_YEAST/5-360         SS    ..............X-XXXXXXXXXXXXX....XXXXXXXXXXXX............XXXXXXXHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHH......H-CCHHCS-HHHHHHHHHHHHHHHHHHHHHHHHHHHCTTEEE........-.SSEEEE-SEE...EETTTTEEEEHHHHHHHHHHHH-..CCCS--TTSHHHHT-SSHH.HHHHHHHHHHHHHHHHTS-HHHHHHHHCCTT-TTEEEEEETTTTEEEEEE--........------HHHHHHHHHHHHHHHHHTS-HHHHHHHHHHHHHHHHHHHHHHHHHTHHHHTSSTT-CH.HHHHHHHHHHHHHHHHH.........HT-SS----SHHHHHHCHXHHHHHHHHHHHHHHHXXXXXX........................
E7KT96_YEASL/5-360                  ..............f-PNKGEIIRELLKD....PLILKNDSKRSn............gSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR........................
Q6CUS2_KLULA/12-352                 ...............LSDTSALSQAIEAD....PQFKSSDSVHP..............KPNSKLLEEVLREDSDLTKDLAKYNQYKILSDLLKEFNTNYELNELENCYYSLQNIHKKFK......-DVNISGESFRFQQSVATYIDCLHLNVLERFKEV-SNMFYTI........S.GNEMMFKKTI...--ELDSVEFNFDEMVELFENNFF..DHNMIDQTHWFIASTNLET.YKDKEIVLLQEILDDTVKLNPLIKFFKEFVFDEKCIMVRAE-----PGKLTL........ATSEYNSLDQIKSYQTLTTFIENDLSKHAKESVMIHFGNVLLTELLKIIRANPELLSNDKEQT-.TEIISSIHDSLTKISEE..........--TEWAYDGFELNRILKDENIYTTLKFESMMQQRVIQIR........................
#=GR Q6CUS2_KLULA/12-352      SS    ...............XXXXXXXXXXXXXX....XXXXXXXXXXX..............XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX......-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXX........X.XXXXXXXXXX...--XXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----XXXXXX........XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-.XXXXXXXXXXXXXXXXX..........--XXXXXXXXXXXXXXXXX--HHHHHHHHHHHHHHHHHH........................
G0V593_NAUCC/12-369                 ...............LGNRDALIQSIEQNletpPLTATHDGNSS..............-TQELNRGQLMMKEEQLSSQLHDLNNLKILSGLLIEFKTNFELLELENCFYSLQSIRKRINg....nNNSSFLKQSFHFQRSVAVYVDTMHSTLIDKIFEIITTKFWQI........NdTGSIAFHKKI...TYGPEDIDLEYESFIDFVKQQYF..PQNVLDSQLWIISDMDIND.LQENVRGKLQTILKSYIHLNVVIDRIKKSIFTKGKMFDYELGKLLFKDVSNI........TDNQSLLQETIASFTSLVRFFQDILIEDDCITVLTSLGNVISNELTKLVKQNASVILND-NSPL.KDRIIEVSKSLVKLADR..........TKNQWHFNDSEILNILNNEQIYFNLMLDKKFNEALEYMR........................
J7S867_KAZNA/6-376                  ..............a-PEREEVLLSVERD....PIFQGENGADVaa.........snyTQLTERIREVVAQEAQLGSMLHDLSVLKTFGDLLNEFNTNLAKSLFQDCYRALQTLRQKLN.....tSRDCFVKQPLHFQRSLMNYIDELHLTLIERIYEIISTDFWSV........T.HDSITFHNKI..vCSEGSGGQFEYRQFMELVKKLFFwdDGEISTEDTWFLKDMDLNNpSSNIVRNKLSEISKNYLELNEIVVNLKRGIFDNSIKFEFQAESCTLSFTKVKnaipnssgSYNKAALASVVESINALADFLMQCIDGNDLVIILSKLGPLLSNELLNFLRKNATVILRDSDPSI.REGIVLINNRFGVLASK..........SNGFWNHNRNDIEHLLNDKQLYINLLVDDAFAKTFKEIR........................
G8BQ21_TETPH/10-363                 .............vl--NEQSIKESLLQD....PLLFRNKSGDSvd..........snSNELLSFESVMNKDTALVAELHDLNSLKQISDLILEFNANWEYIEVENCYYSLLNLRKKLK.....qNDTVLAKQNIRFQQSVITYVESLHLKLIEKVSDLLTEKFWNI........T.SNSVVYNASV...--ELNNVKFEYKPFLEFLSNELIieNDNILDLNNWFIKDMSLGE.LHNMVRNKMKIILNDYLHFELLLNKLKEALFNSNMKFDYDVNNR--KLSWEE........NYHDVKSKDKLESLTNIVNYMNTELSELNSK-LIEKLSPLVANEFTKLVKGNISEIVQNENL--.STTVLTLNESINNLKSF.........tQTASWYFDTAVINDLLKSKEVYNNLILDQILESHLEQLR........................
J8Q396_SACAR/5-358                  ..............s-HNKDEIIRELRKD....PLVIKSDNQKIn............sGELKLDSSELLRQEATLANELNTLDNLKALSTLIVEVKTNLDLLELENCFYSLQSLRTKMR......KNTAFLKQSFNFQQSVSSYVDTLHLELVNALHKILTTGFWKI........T.ENSIQFTPTV...KWGKNEVDIEYDTFMDFVVRQYF..PQSSLDNQAWIISDMGNAD.SQEQVRAKLNTILKDYINLTSVVNMIKCSIFIPGRQVSYEEEKNMLVFSQSS........LQNN--TSAALTSFETVCDFVLDRLSLRDKKTLSYELGHLFNTEFTKFVKNNASIILDSLDSPL.KKLVSVTNDKLIRLASE.........tGVTNWSYSGKEIQDLLMNKQLYYNLLLDKILESHIKDLR........................
A0A0H5CJT4_CYBJA/13-171             vldklvgeitdvkkl--------------....----QEQLTLK..............-VDTQQLGELESKDIELQDELDQLQELWYLMTLQKEIEVNVDLFEFETVFHSLSKLKSKVD......-QMNIKSD--AIRSKLMMEGSRLEDLAVNKLLDCWDQ-IVHV........T.GGSVTLNSEI...HVDG-------------------..-------------------.----------------------------------------------------........----------------------------------------------------------------.-----------------..........---------------------------------------fpisfeavvlivehyslpqprfnl
S6EM73_ZYGB2/12-362                 .............ll--NKDSVLASLKDD....PLLTGAKDELTn............nDPATLDYDAILRKDSRLSQQLHDLSSLRSVSGLIMEFKANFELLEFENCYYSLQSLRKKLR......DNAAINKQGVSFQQSVLAHTDAMHSQLVHKFYEIITQHFWQV........T.DESIAFEPIV...RLGVDSENLDYVSFMRFIEQQFY..PDGFLDANMWIIGDMRVGP.TQDAVISELNAIFHDFLNFRMIIEVIKKFLFSKAKQIVFERGNC--VKLSLH........RGGEDNVSDRIANINNVACFLCEGISVRDIDTFAKKLGPVLATELIQTIKSNPYTVLPSSHSQI.RADVAMANQNLRQLAKK..........--SNWTYHGSDVENLLNDNQVQNSLLLDGIFERYALKIR........................
G8ZQK5_TORDC/17-366                 ...............LADRNGILHQLEDD....PVLINDELREP..............--SKIDTDAILKREMGLSRELREYTALKTVPSLVLEFKTNLHLLEFENSFYSLQTLRKKLR......DFSEILSQSYGLQRSVATYVDNMHLDLVNSLYSILNDGFWKI........G.SDFVSFQEKV...AFGNDRVDIDYVDFMASMVSLYF..PQGHLDPKSWIISDMILGT.MQETVRAKLDFILKEYVKLSGVTNLIKSCIFAQSSEALLEDNNKTLKFRQSS........KKGDEKFKETLSSFKNVLQFLTETVVSQDKKILAERLGPSISTELMKSIKANASIIFRPENTHL.RDESLAINLILKDLSEN..........-SDIWSYNGSELERLFSNSDIPTNLQVDKILQDQLTELR........................
Q6FNZ0_CANGA/3-351                  ..............y-ADKDHVITELLKD....PVYLSRHNSLA..............-THPKDENDLYALETKLEEELHDLKDLKIVSSLVKETQVNLDLMELENCYYSLYNLSKKLK......SSRSFLKQSLHFQRSVAVHVDELRIKLLSTIYDILATKFWSI........S.ESSFEFHPDI...KWKEEEFMMKYEEFKSFVSKSFF..PDNAINNSHWLITDIIHSE.EQERMRNKLKDIYINYIDFASLTKAVKDALFSDEYEFEWSDNNY--TKLLIT........KRGALCIQKRIESFNNLLSFLEKGISNSDKFKLLTNLGKAIGIEFLRFVKSNATGIIDKNANSI.KQQTLLLNDRLKTISEQ..........-SGAWNFDSDQISKLLNDEILYKSLLLDGVLGRAISDVR........................
A0A0A8L3N0_9SACH/12-352             ..............l-DDTSVLSQHIEAD....PQYKGSDLIDS..............KPAARLLEEVLREDSNLTKDLAKYNRYKVLSDLIKEFNTNFELDELENCYYSLQNLCKKFQ......-EVDISDESFRFQQSVATYIDCLHVNLLLKLKDV-SNKFCVV........S.GNELVFKKAI...--KVESVEFKFDEIMELCENNLF..DHQTIDQTHWFITSTNLET.YKDTEIPILHEILADFIKLNPLIVFFRNFAFGDNSVLSREG-----PGKLRI........STTKISALKQVESYEILTSFMDNDLSISAKRSAISQFGNTLLTELLKIIRKNPELLSNDKEKT-.TQLITSIHGSLSRISKD..........--TKWPYDDCELNKILKDENIYTTLKFETMMQQRIAQIR........................
C5DYW5_ZYGRC/12-364                 .............ll--SKAEILESLGKD....PLLVNEKESKSd...........nkDDTPVDFEGILKRESSLNQELHDLASLRSISGLIMEFKANFELLELENCYYSLQNLRKKLR......DTSSLTKQSFSFQQSVFSHVDTMHLQLVGKLYEIISQWFWQV........N.GDSITFKRLV...ELGEDSETMEYVPFITFVEQQYY..PDGFLDPDLWVIRHMKVGS.SQDTVVENLNSILRDYLNSNLMIETIKRFLFAKGGKITWEDLGNT-QKLHFK........QSGTDKVGERISNILNVVSFLNEGITPHDKHALAEKLGPLLANDLLQSVRSNAYSVLHSSDSPL.REEVSLVNEKLKFLSND..........--TRWNYQSNDVEDLLNDDQVHKNLLLDGVFENYALKIR........................
Q752C3_ASHGO/45-390                 ..............l-GNPMQVLAAIEDD....PSLWLDSSEKK..............-PNHLALQELKQRDVEVTKTLQQHLRLKIVADLLIKYNSEIQCAEFTAAFETLRQCVQKAK......-SADVSAHGVRFEQAFNTYLSGLHAVFVRKLQGLLEE-VWHI........H.DDGFSFQQQVsekLDDAREHNFDYDTLVDMFNSCFL..KDGDIDERSWFFKNISMPD.VRDDVKQCVNSTYNNYIKLSQVKENLKGFLFSDSLRISCS------GTRLHV........DQGCETPAAKVESYVVLADYLLNVLSPVASNQILMTLGGAIVTEATKLLKQHSKELLSKEANQ-.KKDLAHFNDTLVKLSSR..........KGSSWTYNGNALDKLLNDPETFATLMFEQHVHLHLLKLR........................
A7TF57_VANPO/11-362                 ..............v-ADKERLLQLLRND....PLLSLNDDVEI..............-TEKIDLEGLLKLDASLTEELHVLNSLKTIPSLILEFKANMEYLELENCYYSLQNLRKKLK......ENDTLVRQNIRLQQSVATYVDSLHVQLVDKLFDLISNHFWNF........K.EHTISHKDEI...VYGKDKVKFDYETLLEFVNRDIF..PQNVLDFEHWLIKDMVMGD.LQEIVRERLSTIVKSYILFDSIIHDVKENIFNDKGIFTYDEDSKKLSLVDSR........SKDLDLLTEKLVGFGKLADYLLSCISKRDVVILSSRIGPSIAKESHKLIKENISSILQEQSTSI.KNLILELNDKLLSLSNA..........TNGVWNYSGNETEELLNDKQIYNNLLLDKIFEEQVNRIR........................
I2GW53_TETBL/22-390                 ...............LNNRDILVASIKND....IESTIEDSPTQppt.......iethIKAHIDPFVIQQEDTQLSNDLYELNKLKTITSLIMEFKTNYELMEYENCYYSLQNLRKKIH......ENEPILVKNYHLKQSLSSYADGLHVQLIEAIHSLVSKGFWKIptvsasdnQ.NVSIEFQKII...HWGNGHIEFEYEFFIDFLRDALF..PDSKFDLQNWLITELVSTD.LQQIVKDNMDSLFNEYIQFSTLVHVLKTGIMNRNYSIVLTGEASNIINLQTK........LNSKSSIQDYLYSLENIIEYLKNTLLERDSITIFNQIGNYFFNEIIKLIKSNTYIILEDDGNDIlKSQISKICNTLSFLSKR..........NTSIWKFDEDEITHLLNNRQLQSNLLVDKLFETKITTIR........................
K0KHW4_WICCF/11-177                 ...leslnekihqlv-------------D....PEVLNSQLNGS.............kTLDFNTISKLQQRDYEITQELQQLREFWIVSTLLKETEVNLDLFEFENVLYSLKNFEKKIK......-SDSFDTKLIILEKLQAEH-DRLYNLTIENIGTSWSK-LIEV........Q.ESSVTFNAEV...DIN--GNTVLYESVSDVIKSN--..-------------------.----------------------------------------------------........----------------------------------------------------------------.-----------------..........---------------------------------------dlqlkvpnsnii............
G0WD68_NAUDC/10-396                 ...............LSNKDELISSIKDD....LLLLQNKNNITttgndaeddlnvskMDKTPDVNTILTKETQLATELHDLQQLKTISSLIMEFKTNFELFELENCFYSLQSLRKQIGtitinnNNPSFARQNYHFQRSVIVYIDSLHLDLISRIFEIITLKFWNI........T.SESISFNPKLnvqTTDGLDVEIAYDSFISSIKNLYF..PNDIIDSEFWIISNVELND.LHESIRNKLQTIFKDYINLDGVSAMIKNAIFTNNKQFKYANNKLSIISSLTS........MNQTDFLTTTIESFQNIITFLNETLPLQDRNILLSKLGNTITTELLKFVKVNISKILNNENSNLmKDQTLKINTELITFAKHftlsssshsgLNNFKNYDGQQIIELLNNNRIYYNLLLDNSLYDQIKQMR........................
H2AUI4_KAZAF/5-354                  ...............LPDRETLISLVEQN....-LILKNKNTID..............-DPSLEMNKILEEESKLSEELRDLTKLKTISSLLKEVNVNFELLEFENCYYSLKSLRSKLT.....eNNSVFIKQTYRFQRSTALYIDSLHSKLIDSIHEVITTKFWNI........T.SNTIKFNPKI...KIGDDDVQFDYTEFMSFAKSSFF..TKDTSSSEFWFLATMELGD.YKENVRSKLNDINRNFIEFNNIIGSIKNLIYDDSVNVTYSTQDN--ILSFQK........GESNDYLEKIIEKSQAIVNFLTETFLPNNLYVIVSEVGSLLSTELFKTAKSNASQLLRDRKNPL.IDLVRSINSSLIKLSNE..........IKSNWKYNGSDIDHLLNDEKVYINLLIDKTFDAEIKMLR........................
C5DK93_LACTC/23-365                 ...............LNDQDAILAGIESD....PNLKMEGSARR..............-EEPSDVQAILNQDVQLSKKLGALKELNLVANLIDEFKANFELWELENCYYSLQNLHKRLE......-KVDMSLFPIQFQGLLKVHIDSLHVDLLSRIDKVMRQ-FWDI........S.ARSVTFNQKI...AVDRDDVLLEYDSFSLFLKSCFF..SQDHFEPTSWFVATMNMGD.AKDKVTNLLATAFNEWVRLQTVQEKLKQFLFSANVCLSLK------GCTLGA........SENPGNLDDTLKSFEALVMFMKDVTTAEDTAVILAKLGNTLLTEIVKFVKQNSSHLFAPGTNY-.KNSVVSLNTMLTELSHK..........GGKSWQYAGRELDNLINDDSVINNLMLDKLLQEQISAIR........................
E7Q870_YEASB/5-360                  ..............f-PNKGEIIRELLKD....PLILKNDSKRSn............gSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKXLYYNLLLDKVLESHISEIR........................
E7QJM0_YEASZ/5-360                  ..............f-PNKGEIIRELLKD....PLILKNDSKRSn............gSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKXLYYNLLLDKVLESHISEIR........................
E7LZD1_YEASV/5-360                  ..............f-PNKGEIIRELLKD....PLILKNDSKRSn............gSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..PKGSLDNQAWFILDMTSAD.SQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIR........................
#=GC SS_cons                        ...............XXXXXXXXXXXXXX....XXXXXXXXXXX..............XXXXXXHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTXHHHHHHHHHHHHHHHH......HXCCHHCSXHHHHHHHHHHHHHHHHHHHHHHHHHHHCTTEEE........X.SSEEEEXSEE...EETTTTEEEEHHHHHHHHHHHHX..CCCSXXTTSHHHHTXSSHH.HHHHHHHHHHHHHHHHTSXHHHHHHHHCCTTXTTEEEEEETTTTEEEEEEXX........XXXXXXHHHHHHHHHHHHHHHHHTSXHHHHHHHHHHHHHHHHHHHHHHHHHTHHHHTSSTTXCH.HHHHHHHHHHHHHHHHH.........HT-SSXXXXSHHHHHHCHXHHHHHHHHHHHHHHHHHHHHH........................
#=GC seq_cons                       ..............h.ss+spllppltpD....Pllhpscspcs...............ptplDhsclLp+-spLupELppLssLKslusLIhEhKoNh-LhELENCYYSLQsLRKKl+......sssshh+QuapFQQSluoYlDsLHlpLlsplacllostFWpI........o.psSIpFpspl...phst-cVch-Y-sFh-FlpppaF..PcshlDsptWhIt-Mshu-..p-pVRs+LssIh+-YlpLstllphlKpslFssstphsacsppp..shphsp........spsppplpshlpSapslssFhhcsls.pDppslh.cLGshlsTEhhKhlKsNuohILpstsssl.+s.lshlNspLppLupc...........sspWsasGp-lpcLLpscplYhNLLLDplhppplpplR........................
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