GenomeNet

Database: Pfam
Entry: ECSIT
LinkDB: ECSIT
Original site: ECSIT 
#=GF ID   ECSIT
#=GF AC   PF06239.8
#=GF DE   Evolutionarily conserved signalling intermediate in Toll pathway
#=GF AU   Finn RD
#=GF SE   Pfam-B_9306 (release 9.0)
#=GF GA   25.90 25.90;
#=GF TC   25.90 41.40;
#=GF NC   25.80 25.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10465784
#=GF RT   ECSIT is an evolutionarily conserved intermediate in the
#=GF RT   Toll/IL-1 signal transduction pathway. 
#=GF RA   Kopp E, Medzhitov R, Carothers J, Xiao C, Douglas I, Janeway CA,
#=GF RA   Ghosh S; 
#=GF RL   Genes Dev 1999;13:2059-2071.
#=GF DR   INTERPRO; IPR010418;
#=GF CC   Activation of NF-kappaB as a consequence of signaling through
#=GF CC   the Toll and IL-1 receptors is a major element of innate immune
#=GF CC   responses. ECSIT plays an important role in signalling to
#=GF CC   NF-kappaB, functioning as the intermediate in the signaling
#=GF CC   pathways between TRAF-6 and MEKK-1 [1].
#=GF SQ   121
#=GS ECSIT_BOVIN/45-266        AC Q3SX05.1
#=GS D6WU07_TRICA/20-227       AC D6WU07.1
#=GS B4I491_DROSE/28-243       AC B4I491.1
#=GS ECSIT_RAT/44-265          AC Q5XIC2.1
#=GS G1KZL1_AILME/44-267       AC G1KZL1.1
#=GS F1SA28_PIG/45-266         AC F1SA28.2
#=GS ECSIT_MOUSE/44-266        AC Q9QZH6.2
#=GS G5AJT8_HETGA/13-235       AC G5AJT8.1
#=GS A0A068Y954_ECHMU/38-272   AC A0A068Y954.1
#=GS E4WXP1_OIKDI/2-214        AC E4WXP1.1
#=GS K7EIK2_HUMAN/1-59         AC K7EIK2.1
#=GS H9JC15_BOMMO/1-168        AC H9JC15.1
#=GS G3QRT8_GORGO/45-266       AC G3QRT8.1
#=GS M7BJ86_CHEMY/1-212        AC M7BJ86.1
#=GS I3J7H1_ORENI/58-279       AC I3J7H1.1
#=GS B0W9N2_CULQU/23-241       AC B0W9N2.1
#=GS Q297W7_DROPS/32-249       AC Q297W7.2
#=GS E2APA7_CAMFO/27-243       AC E2APA7.1
#=GS E0VBY4_PEDHC/53-269       AC E0VBY4.1
#=GS G3N6W3_GASAC/29-248       AC G3N6W3.1
#=GS H2WIH1_CAEJA/10-222       AC H2WIH1.1
#=GS G1PUE5_MYOLU/45-267       AC G1PUE5.1
#=GS A7RKS6_NEMVE/10-226       AC A7RKS6.1
#=GS J9EFB6_WUCBA/22-224       AC J9EFB6.1
#=GS A0A077ZCQ6_TRITR/14-246   AC A0A077ZCQ6.1
#=GS B4JGQ9_DROGR/37-256       AC B4JGQ9.1
#=GS W5KG78_ASTMX/55-276       AC W5KG78.1
#=GS F1QSV0_DANRE/56-279       AC F1QSV0.1
#=GS F7EV14_ORNAN/50-273       AC F7EV14.2
#=GS A0A088A142_APIME/1-146    AC A0A088A142.1
#=GS W5MLR1_LEPOC/69-297       AC W5MLR1.1
#=GS T1JZX1_TETUR/91-295       AC T1JZX1.1
#=GS F4W6S6_ACREC/28-243       AC F4W6S6.1
#=GS B4K710_DROMO/13-231       AC B4K710.1
#=GS E2RB15_CANFA/45-266       AC E2RB15.1
#=GS A0A087Y4Y5_POEFO/51-271   AC A0A087Y4Y5.1
#=GS C3Z7S7_BRAFL/32-251       AC C3Z7S7.1
#=GS T1IF30_RHOPR/2-203        AC T1IF30.1
#=GS B3LWB9_DROAN/24-240       AC B3LWB9.1
#=GS H2M860_ORYLA/57-273       AC H2M860.1
#=GS G6D235_DANPL/1-168        AC G6D235.1
#=GS K7EJI1_HUMAN/1-102        AC K7EJI1.1
#=GS A0A0A0MUD4_PAPAN/44-174   AC A0A0A0MUD4.1
#=GS W4Y8N6_STRPU/52-261       AC W4Y8N6.1
#=GS G1RPX7_NOMLE/44-266       AC G1RPX7.1
#=GS M4A0F8_XIPMA/49-271       AC M4A0F8.1
#=GS L8YIA6_TUPCH/35-257       AC L8YIA6.1
#=GS G7PZF5_MACFA/44-266       AC G7PZF5.1
#=GS F7BSY7_MACMU/44-266       AC F7BSY7.1
#=GS G4VSP0_SCHMA/56-282       AC G4VSP0.1
#=GS U1MRY7_ASCSU/25-127       AC U1MRY7.1
#=GS E5SIB9_TRISP/1-165        AC E5SIB9.1
#=GS T1J3B0_STRMM/46-261       AC T1J3B0.1
#=GS B7PYZ8_IXOSC/41-253       AC B7PYZ8.1
#=GS A9V8X9_MONBE/6-206        AC A9V8X9.1
#=GS K1PQT7_CRAGI/45-285       AC K1PQT7.1
#=GS B4QXL9_DROSI/27-242       AC B4QXL9.1
#=GS ECSIT_HUMAN/44-266        AC Q9BQ95.1
#=GS E2BJP5_HARSA/36-253       AC E2BJP5.1
#=GS M3W343_FELCA/45-268       AC M3W343.1
#=GS A8WQY1_CAEBR/5-221        AC A8WQY1.2
#=GS B4G354_DROPE/32-249       AC B4G354.1
#=GS J9K9S4_ACYPI/16-231       AC J9K9S4.1
#=GS Q7QI51_ANOGA/26-242       AC Q7QI51.4
#=GS E9HFW4_DAPPU/30-241       AC E9HFW4.1
#=GS T1G2K8_HELRO/1-161        AC T1G2K8.1
#=GS A0A068X7Y8_HYMMI/165-399  AC A0A068X7Y8.1
#=GS H2U7Y8_TAKRU/10-230       AC H2U7Y8.1
#=GS Q9N580_CAEEL/5-222        AC Q9N580.1
#=GS F6X0J0_CALJA/44-266       AC F6X0J0.1
#=GS G1SLP7_RABIT/45-266       AC G1SLP7.1
#=GS K7EN32_HUMAN/1-150        AC K7EN32.1
#=GS F8W5R4_DANRE/56-139       AC F8W5R4.1
#=GS G3VS11_SARHA/52-270       AC G3VS11.1
#=GS F7BSY0_MACMU/44-266       AC F7BSY0.1
#=GS F6TG92_XENTR/31-260       AC F6TG92.1
#=GS V3Z2D1_LOTGI/1-183        AC V3Z2D1.1
#=GS B4NHG1_DROWI/26-244       AC B4NHG1.1
#=GS W5JEM5_ANODA/23-236       AC W5JEM5.1
#=GS E3M651_CAERE/9-222        AC E3M651.1
#=GS ECSIT_XENTR/31-252        AC Q0V9C9.1
#=GS J3KTF5_HUMAN/1-150        AC J3KTF5.1
#=GS F2TZC5_SALR5/121-311      AC F2TZC5.1
#=GS H0W0W4_CAVPO/13-235       AC H0W0W4.1
#=GS A0A044T7Z7_ONCVO/21-236   AC A0A044T7Z7.1
#=GS A0A0B2VLD0_TOXCA/34-253   AC A0A0B2VLD0.1
#=GS ECSIT_DROME/27-242        AC Q9U6M0.2
#=GS G3H694_CRIGR/45-265       AC G3H694.1
#=GS I3M2P2_SPETR/44-266       AC I3M2P2.1
#=GS Q17B53_AEDAE/23-247       AC Q17B53.1
#=GS H2XTD8_CIOIN/1-187        AC H2XTD8.1
#=GS A0A067QJH9_ZOONE/45-252   AC A0A067QJH9.1
#=GS H0WVJ4_OTOGA/44-266       AC H0WVJ4.1
#=GS J3KMM6_MOUSE/1-196        AC J3KMM6.1
#=GS A8PQM3_BRUMA/18-235       AC A8PQM3.2
#=GS M3Y0V6_MUSPF/47-269       AC M3Y0V6.1
#=GS F7FTB5_MONDO/50-270       AC F7FTB5.2
#=GS A0A091E148_FUKDA/46-269   AC A0A091E148.1
#=GS G7YTU4_CLOSI/249-431      AC G7YTU4.1
#=GS U4UCT0_DENPD/1-208        AC U4UCT0.1
#=GS W4WM45_ATTCE/28-242       AC W4WM45.1
#=GS G1KTD3_ANOCA/53-274       AC G1KTD3.2
#=GS W5QB33_SHEEP/45-266       AC W5QB33.1
#=GS K7IYE0_NASVI/45-280       AC K7IYE0.1
#=GS E9ICX0_SOLIN/32-245       AC E9ICX0.1
#=GS L5L303_PTEAL/79-301       AC L5L303.1
#=GS H3BCG7_LATCH/56-279       AC H3BCG7.1
#=GS U1MRY7_ASCSU/125-217      AC U1MRY7.1
#=GS K7EPL5_HUMAN/44-227       AC K7EPL5.1
#=GS B4MC61_DROVI/252-471      AC B4MC61.1
#=GS G3UEA5_LOXAF/14-237       AC G3UEA5.1
#=GS B3RPX5_TRIAD/54-259       AC B3RPX5.1
#=GS E1FZ24_LOALO/23-240       AC E1FZ24.2
#=GS I1FRG8_AMPQE/1-166        AC I1FRG8.1
#=GS A0A0D2VSR5_CAPO3/106-322  AC A0A0D2VSR5.1
#=GS A0A0D9R327_CHLSB/13-235   AC A0A0D9R327.1
#=GS H3CG44_TETNG/55-277       AC H3CG44.1
#=GS L5LRL6_MYODS/69-290       AC L5LRL6.1
#=GS ECSIT_DANRE/56-279        AC Q08CK1.1
#=GS K7EJG5_HUMAN/1-53         AC K7EJG5.1
#=GS F6YXE5_HORSE/45-266       AC F6YXE5.1
ECSIT_BOVIN/45-266                   ............................................aa--AHNPDSSLVP--HPPEPPRRPVKAL......AVHEELFRPALD.GARNKANFVRAV.....QN..........FTE..YN.V.HKRGHVDFIYLALRKMREYGVERDLSVYNLLLDIFP.K.E..VFR...P......RNIF.HSIF.....L....HYPRQQECGIAVLEQMENH..G........VMPNKETEFLLLQIFGRKSYPMLKLVRMKLWFTRFKNINPFPVP....RDLP.....Q...DPVDLASLALRHMEP.DLSARV..TTYQ.MPLLKDS.PNAMDPTETHIVG........................
D6WU07_TRICA/20-227                  ..................................vgplartfsdss----------------------EPKQL......-VTYRSFEEI--.ETKNKNTYLDMI.....HI..........FVN..RDsV.HRRGHVEFIYSALKNMESFGVHKDLEVYKALIDVLP.K.G..KFI...P......RNMF.QVEF.....M....HYPKQQQCIIDLLEQMEDN..A........VMPDYDMEELLKNIFGNRGFPLRKYWRMMYWMPKFKNASPWPIP....NPLP.....D...GVYELAKCAIERISSvDIQTQV..TTYQ.SKDIEDC.VD-----DTWIIS........................
B4I491_DROSE/28-243                  .......................................atdegnp------KQNPNPNPRA---QKPGTKNL......PALRNPFTAA--.QDRTKNSYLTMV.....EI..........FQE..RD.V.HRRNHVEFIYAALKNMADFGVERDLEVYKALINVMP.K.G..KFI...P......TNMF.QAEF.....M....HYPKQQQCIIDLLEQMEDC..G........VMPDHEMEAMLLNVFGRQGHPLRKYWRMMYWMPKFKNLSPWPLP....DPVP.....D...DTLEMAKLALERMCTvDLRSKI..TVFE.TSELKDA.ID-----DTWIVS........................
ECSIT_RAT/44-265                     .....................................avthkddvw---------LVP--RPSEPQKKPIKVP......AMHEDLFRPSGN.GEQDKASFLNAV.....RS..........FGE..HN.V.RKRGHVDFIYLALRKMPEFGVERDLSVYNLLLDVFP.K.E..VFR...P......RNAI.QRIF.....V....HYPRQQECGVAVLEQMERH..G........VMPNTETEFLLIQVFGHKSYPMLKFLRMKLWFTRFKNINPYPVP....RDLP.....Q...DPLDLAKLGLRHMEP.DLSAKV..TVYQ.MSLPSES.TGIEDPTQPHIVG........................
G1KZL1_AILME/44-267                  ...........................................laa---RNSDSWLVPPPPEPRKGPRPTKAL......ALHEELFQQAPE.GARDKANFVRAV.....QN..........FGQ..HN.V.HKRGHVDFIYLALRKMREYGVERDLAVYNLLLDVFP.K.E..VFR...P......RSIF.QSIF.....I....HYPRQQECGIAVLEQMESH..G........VMPNKETEFLLIQIFGRKSYPMLKFVRMKLWFSRFKNINPFPVP....RDLP.....Q...DPVDLAKLGLRHMEP.NLSATV..TIYQ.MPSSKDS.TGAADPAEPHIVG........................
F1SA28_PIG/45-266                    ...................................tamhtfdsslv-----------P--HPPKPPRRPIKAL......ALHEELFRKAPD.GTREKASFVQAI.....QD..........FAQ..YN.V.HKRGHVDFIYLALRKMREYGVERDLAVYNLLLDIFP.K.E..VFR...P......RSIF.QTIF.....Y....HYPRQQECGIAVLEQMENH..G........VMPNKETEFLLIQIFGRKSYPMLKYVRMKLWFTRFRNINPFPLP....RDLP.....Q...DPVDLARLALRHMEP.DLSARV..TVYQ.MSLPEDS.KDAVDPTEPHIVG........................
ECSIT_MOUSE/44-266                   ..........................................saat---HKDEPWLVP--RPPEPQRKPIKVP......AMHEDLFKPSGN.RERDKASFLNAV.....RS..........FGA..HN.V.RKRGHVDFIYLALRKMPEFGVERDLSVYNLLLDVFP.K.E..VFR...P......RNVI.QRIF.....V....HYPRQQECGVAVLEQMERH..G........VMPSAETEFLLIQIFGRKSYPMLKFLRMKLWFTRFKNINPYPVP....RDLP.....Q...DPLDLAKLGLRHMEP.DLSAKV..TVYQ.MSLPSDS.TGMEDPTQPHIVG........................
G5AJT8_HETGA/13-235                  ...........................................ssa--HRTSEKSVVP--HPPEPGKKPVKVP......VPYEDLFQLAPG.GTRDKASFMKAL.....QS..........FGQ..HN.V.RKRGHVDFIYFALQKMPEYGVERDLAAYNLLLDVFP.K.E..VFR...P......RNFI.HTLF.....F....HYLLQQDCGVAVLHQMESN..G........VMPNKETEFLLLQIFGRQSYPMLKYMRMHLWFTRFLNINPFPVP....RDLP.....Q...DAVELATLGLQHMEP.DLSARV..TVYQ.RPLPDDK.TDPGDPTKPHIVG........................
A0A068Y954_ECHMU/38-272              .........ddktssaktepqsepthaeliwaevsksfennklaka---------------------------......SQTTMGLKRSQL.KQLKKAAFLDAV.....EL..........YKA..HS.GsARRGFNEFILVAMREMRAYEVEDDLESYKALLSVLP.R.E.gRLK...A......KSIL.HADV.....G....GYKQQQDTVVRLLLQLNAN..H........VIPDDDVGNTIVEVFGFRSYVMTHYRRMMYWVPKLRHANPWPVV....GRLPddiegE...DAIRLAQLAAARICP.DPNTEF..TTIV.VESKE--.-------------agtpncivs...............
E4WXP1_OIKDI/2-214                   ..............................dksyanemeayladae---------------------------......--------HSYI.QEADKRAFYMAV.....EL..........WKK..EA.GpGRQGHKDFVVMAIPTISQLGLSKDTKAYMTLLECWP.D.AnyVFA...EkspiykQTTS.QSTF.....FiekfEWTSDANLCKHLLRTMERN..G........CLCTNEIYAKVTDLFGIYSDASVLARQQMLFNKRLMERNPFPI-....-DAP.....K...DPTELAAATLRQASP.GFDRQY..HRFP.MKQRD--.-------------gnwvrseksgef............
K7EIK2_HUMAN/1-59                    .............................................x---------------------------......------------.------------.....--..........---..--.-.---------------MREYGVERDLAVYNQLLNIFP.K.E..VFR...P......RNII.QRIF.....V....HYPRQQECGIAVLEQMENH..-........--------------------------------------------....----.....-...---------------.------..----.-------.-------------aqv.....................
H9JC15_BOMMO/1-168                   ..............................................---------------------------......------------.------------.....-M..........FEN..QD.N.RRRGHVEFIYAALARMKEFGVHKDLQAYKALVDVLP.K.G..KFI...P......SNIF.QAEF.....M....HYPKQQQCAVDLLEQMEDN..K........VMPDSELEQMLLNVFGKRGIPLRKFWRMLYWMPKFKNLSPWYLP....DELP.....N...DTLELAKMAIHRITSvDPTMKI..EIWQ.TEEIEAC.ID-----KTWIVS........................
G3QRT8_GORGO/45-266                  .............................................a-AAHNSEQSLVP--SPPEPRQRPTKAL......VPFEDLFGQAPS.GERDKASFLQTV.....QK..........FAE..HS.V.RKRGHVDFIYLALRKMREYGVERDLAVYNQLLNIFP.K.E..VFR...P......RNII.QRIF.....V....HYPRQQECGIAVLEQMENH..G........VIPNKETEFLLIQIFGRKSYPMLKLVRLKLWFPRFMNINPFPVP....RDLP.....Q...DPVELAMFGLRHMEP.DLSARV..TIYQ.VPLPKDS.TGAADPPQPHIVG........................
M7BJ86_CHEMY/1-212                   ............................................dk----------------EKERGSRDGAL......VPFDELFERACK.GDRNKATFSRAV.....EL..........FCQ..RD.I.RRRGHIEFINAALRKMPEFGVERELDVYNKILDVFP.K.E..VFV...P......RNFI.QRMF.....N....YYPRQQECGIHVLDQMENHgrG........IMPNKQTKFLLLQIFGEKSHPVRKYQRLMYWFPKFKHANPYPVP....AALP.....Q...DPVDLARFSLQRIAA.DLSAKV..TVYQ.MPLTDIL.DAGKEITQPHIV-e.......................
I3J7H1_ORENI/58-279                  .......................................sspactk---------GQPARFVQEEDKTRDKSL......VTHDDLFEQVAK.EAKTKATFNKVI.....DV..........YTK..GD.I.RRRGHVEFIYAALKKMPEFGVEKDLTVYNKLLDVFP.K.E..VFV...P......RNFI.QRMF.....N....HYPRQQECGVQVLEQMENY..G........IMPNIETKVLLVQIFGEKTHPMRKYQRIMYWFPKFKHVNPFPIP....EQLP.....E...DPVDLARFSLTRMAN.DWDAKV..TVYQ.LPCTDVT.ESGAEVTLPHIVG........................
B0W9N2_CULQU/23-241                  ..................................ssstkqpppptp-----------EEDEAEGRKRKPETKL......MLRTELFEHV--.SQKDKRTYIDMV.....KV..........FEG..RS.V.HRRNHVEFIYAALKHMEEFGVQRDLEVYKALINVMP.K.G..KFI...P......TNIF.QAEF.....M....HYPRQQQVIIDLLEQMEDN..G........VMPDYEMESMLINVFGKKGHPVRKYWRMMYWMPKFKNLSPWPLP....NPVP.....D...ESLDLAKLAIERMCSiDLLSQI..SLFD.TKDVADA.LD-----QTWIVS........................
Q297W7_DROPS/32-249                  ..................................nysadetnsnsg------------NPNAKRAGTGGSKSL......PAVRNVFAAA--.QDKTKDTYLTMV.....EI..........FQE..RD.V.HRRNHVEFIYAALKHMPDFGVENDLEVYKALINVMP.K.G..KFI...P......TNLF.QAEF.....M....HYPKQQQCIIDLLEQMEDF..G........VMPDYEMEAMLLNVFGNKGHPLRKYWRMMYWMPKFKNLSPWPLP....NPVP.....D...DTLEIAKLAVERMCTvDLRSQI..NVFD.TKELKDA.VD-----ETWIVS........................
E2APA7_CAMFO/27-243                  ................................drtsyirdfhtsrf---------------RSKDNKEDDKSS......ALVLHAFANA--.ERKEKEAYLDII.....RE..........YKN..NN.E.LRRGHVEFIQVALKYMDDFGVNRDLAVYKVLLDVLP.K.G..KFV...P......TNAF.QTLF.....M....HYPKQQYVAIDLLCKMEKN..C........VIPDVEMQDMLLNIFGKHGAPLKKFWRMMYWMPKFANLNPWPCA....RPAP.....K...DPRILARLAISKISSvDVQTKI..VEFE.TKDIEDA.IE-----DTWIVS........................
E0VBY4_PEDHC/53-269                  ..........................lsktfkhfksiqitsqlkyc---------------------DEKKNK......IITFSDFEKW--.SVKNKESFLETI.....RI..........YEA..TF.P.NRKGHVEFVESALKQMETYGVHKDIEAYKRIIDILP.K.G..VFV...V......KNKW.QATF.....Y....NYPRQQFAAIEMLSKMEHY..G........VLPDAELGSILISIFGKFSQPCLKYFEQLYWCMKFRNKSPWYLP....KQVP.....S...DAFLLAQMAMERITSvDVKTEI..SVYQ.TDDLLES.ID-----KTWIIS........................
G3N6W3_GASAC/29-248                  .........................................gparp------KEQPIPAEFVNGDDKKRDRSL......VAHDDLFERVAR.EVKTKATFNKVV.....DV..........FIK..ND.V.RRRGHVEFIYAALKKMPEFGVERDLVVYNRLLDVFP.K.E..VFV...P......RNFI.QRMF.....N....HYPRQQECGVQLLEQMENY..G........IMPNMETKVLLVQIFGEKGHPMRKFQRIMYWFPKFKHVNPFPVP....KHLP.....E...DPVDLARFSLTRIAN.DRDAKV..TVHQ.WGLLKKD.TQ-----------dsrgvhgg................
H2WIH1_CAEJA/10-222                  ...................................amfyqircfas-------------------ASHEQTSL......VHVEKQFEAVIP.EKRDKDAFMAAI.....AM..........FKE..KR.-.-GRTHVEFINTALKYVKEYGVHKDLDTYKNLLDVFP.K.G..KMI...P......QTAF.QKIF.....L....HYPQQQNCAVKVLDEMEWH..G........VQPDKEIHDIMVNAFGEWNFATKKVKRMLYWMPKLKHSNKYLDR....RHVE.....GkslSPSELAGIALKMMSR.DPASSI..SLLK.FSDSSDP.V------------skwlatsq................
G1PUE5_MYOLU/45-267                  ...........................................vat---HSSDSSLVP--RPPEPLRQPAKPL......SPHEELFRPAPD.GARNKASFVRAV.....QN..........FGQ..HN.V.HKRGHVDFIYLALRKMRDYGVEKDLAVYNLLLDVFP.K.E..VFR...P......RNVF.QKIF.....V....HYPRQQECGLAVLEQMENH..G........VMPNKETEFLLVQIFGRKSYPMLKFVRMKLWFSRFKNINPFPVP....RDLP.....K...DPVDLAMLGLRHIEP.DLSARV..TVYQqMASSKDS.TGTADPTEQHIVG........................
A7RKS6_NEMVE/10-226                  .....................irndtvielsekaiesritsakpap---------------------------......SKFALRFETALS.QGKTRDNFIEIL.....ES..........FSR..HD.R.NRRGHMELLKTAMNYMDIYGLEKDLLAYNAMLDVFP.R.G..RFQ...N......RTLF.DAVW.....P....KKHPQVDLALEILTKMEEN..V........IKPSIETYDICEEIFGKASQPVQKVRRLAYWLTKLEEMFPSPLP....AELP.....E...GELELSMVAMERMSK.EGL---..----.-------.-------------pivvfqdlsegnseefivssqt..
J9EFB6_WUCBA/22-224                  ......................................ycqgyrfa----------------SESSETIRKEL......LPSEQRFDEVAV.ELRSKQTFLNVI.....--..........---..--.-.---GHVEFINAALKYMKEYGLQKDLDIYKSLLNIFP.K.G..PMI...P......TNVF.QQRF.....L....YYPQQQICCIKLLDEMEWF..G........VQPDKEIHDLVVNVFGEWNYATKKMKRMMYWMPKLKHSNGYLDR....RKIE.....GkklSAVDFGYLALKMISR.DPGTRI..TLVE.MNDTELN.ES-----------drwlls..................
A0A077ZCQ6_TRITR/14-246              ....................................grnyfesttg----------------ERKASKFTTAL......TVKDEIFNEIPE.ENRNKETFTKAIgniglAIfchviciaglFLR..TN.T.RLQGHTEFIYAALKRMREFGVHKDLEVYKRLLEVFP.K.G..KMI...P......KNFF.QVRLarvegM....HYPKQQQCCIDVLDEIEWN..R........VFPDKELYMIVKNAFGEWTHAMRKMKRMMYWMPKLKNADPYPMP....RPLP.....R...SEVELAKAAMSRVCR.DPSNIT..NLFY.TEAISEE.-----VEKTWIVS........................
B4JGQ9_DROGR/37-256                  .......................................danrnan-----ADPKSNNKSNKRAGTTSSSKSL......PAIRNPFAAA--.QDKTKNTYLTMV.....EI..........FEE..RD.V.HRRNHVEFIYAALKHMPDFNVEHDLEVYKALINVMP.K.G..KFI...P......TNLF.QAEF.....M....HYPKQQQCIIDLLEQMEDY..G........VMPDYEMEAMLLNVFGNKGHPLRKYWRMMYWMPKFKNLSPWPLP....DPVP.....D...DTLEIAKLAVERMCTvDLRSKI..DVFE.TREIKDS.LD-----DTWIVS........................
W5KG78_ASTMX/55-276                  ..............................tvykdkpdnsdlsklf------------------ENETKAKSL......VTHDDLFERTAK.DAKNKASFNRVV.....DV..........FNK..QD.I.RRRGHVEFIYAALQKMPEFGVERDLAVYNKLLDVFP.K.E..VFV...P......RNFI.QRLF.....N....HYPRQQECAVQVLEQMENY..G........IVPNVETKVLLVQIFGEKGHPVRKYQRLMYWLPKFKHINPFPVP....FELT.....Q...DPIDLARFSLTRIAN.DPDAKI..TVYQ.YPSTDVT.ETGEEVTQPHIVG........................
F1QSV0_DANRE/56-279                  ...........................................vcs---TDRQNRTDIEKLVEDETHHKDKTL......VTHDDIFDRAAG.DSKTKVEFNRVV.....DV..........FKS..KD.I.RRRGHVEFIYAALKKMPEFGVECDVTVYNKLLDVFP.K.E..VFV...P......QNFI.QRMF.....N....HYPRQQECGVQVLEQMENY..G........VMPNIETKVLLVQIFGEKSHPIRKFQRIMYWFPKFKHTNPYPVP....HVLP.....S...DPVDLAQFSLTRIAA.DLDAKI..TIYQ.YPSTDIT.ETGEEITRPHIVG........................
F7EV14_ORNAN/50-273                  .............................aeaagdsqltlgapsgq------------------GQDGAARAL......VPFEDFFQRASG.GSKDKAGFTRAV.....DV..........FNQ..RS.V.RKRGHVDFIYTALRKMKEYGVERDLAVYNLLLDVFP.K.E..VFV...P......RNFI.QRIF.....N....HYPRQQECGVQVLEQMENH..G........VLPNKETEFLLLQVFGKKSYPMLKYHRIMYWFPRFKNINPFPLP....KPLP.....Q...DPIDLARLGLQRIAA.DLSARV..TVYQ.MPAAAEGpAGASALFQPHIIG........................
A0A088A142_APIME/1-146               ..............................................---------------------------......------------.------------.....--..........---..--.-.---------------MDEFGVNKDLEIYKQLLDIFP.K.N..KYI...P......KNKF.QNMF.....F....SYAKHQNVAISILKKMEKN..F........VIPDFEMQELIIQIFGDKNLVIKKCWNIFYWFPKFSQLNPWPIP....RPIP.....T...DPKELAKFAIAKMSCiDVQANT..IVYK.TKDIPDA.ID-----DTWIVS........................
W5MLR1_LEPOC/69-297                  .......................assrrtenkptaaahqggqgdgk------------------SEDGPGQSL......VTHEHLFERAAR.DSRTKATFNRVL.....DV..........FVK..RD.I.RRRGHVEFIYAALKKMPEFGVERDLSVYNRLLDIFP.K.E..VFV...P......RNFI.QRMF.....N....HYPRQQECAIQILEEMENH..G........IMPNIETKVLLVQIFGEKSHPMRKYQRLLYWFPKFKHVNPYPVP....HELP.....Q...DPLDLARLSLKRIAN.SLDAKV..TVYQ.MPSTDIS.EMGEQVSEPFVVG........................
T1JZX1_TETUR/91-295                  ..........................altssnvdydyntvnlvasf---------------------------......-------YNT--.DSKDWEHFNKVV.....EA..........YKKpdKS.G.MRVGQVEFIYGSMKRLKDFGLHKDVRAYNALLDVFP.K.G..KMI...P......ENVI.QFGF.....L....HYAKQQFCAVDLLEEMEWN..Q........VLPDQETIDLVLSIFSVYSQVFDKLGTMIYWTTKARYNDPYPCP....NVLP.....Y...DPKELAKISFRRMCV.DPTTEI..SIYS.TEAVPES.MD-----KTWIVS........................
F4W6S6_ACREC/28-243                  ......................................rslsrvih----------TSQERYKKDDKKDSKSS......ALVLHAFANA--.DSKEREAYLDIL.....RE..........YKT..NN.E.MRRGHVEFIQVALKYMDEFGVNRDLAVYKAVLDVLP.K.G..KFV...P......RNYF.QTIF.....T....HYPKQQHVAIDLLCKMEHN..S........VIPDLEMQEMLLNIFGMQALVLKKFWRMMYWMPKFANLNPWPCP....KPVP.....K...DPKVLAKLAMNKISSaDVQTEV..TEFK.TKDVEDA.ID-----DTWIIS........................
B4K710_DROMO/13-231                  ...............................atdeananhkndssn--------------TKRGGAAGSSKNL......PSIRNPFAAA--.HEKTKNSYLTMV.....EI..........FEE..RD.V.HRRNHVEFIYAALKHMPDFGVEHDLEVYKALINVMP.K.G..KFI...P......TNLF.QAEF.....M....HYPKQQQCIIDLLEQMEDY..G........VMPDYEMEAMLLNVFGNKGHPLRKYWRMMYWMPKFKNLSPWPLP....DPVP.....D...DTLEIAKLAVERMCTvDLRSKI..DVFE.TSEIKDS.LD-----DTWIVS........................
E2RB15_CANFA/45-266                  ....................................aiacnsdswl----------VP--PSPEPPKGPPKAL......APHEELFTQALG.GTRDKANFVRAV.....QN..........FGQ..HN.V.YKRGHVDFIYLALRKMREYGVERDLAVYNLLLDVFP.K.E..VFR...P......RSIF.QTMF.....I....HYPRQQECGIAVLEQMESH..G........VMPNKETEFLLLQIFGRKSYPMLKFIRMKLWFSRFKNINPFPVP....RDLP.....Q...DPVDLAKLGLRHMEP.NLNATV..TIYQ.MPSSKDS.TGAADPTEPHIVG........................
A0A087Y4Y5_POEFO/51-271              ...........................................vla------KSQPEPVRFVNDDGTKKTKSL......VTQEDLFEQVAK.ESKTKATFNQVI.....DV..........FTK..TD.I.RRRGHVEFIYAALKKMPEFGVERDLTVYNKLLDVFP.K.E..VFV...A......RNFI.QRMF.....N....HYPRQQECGVQVLEQMESY..G........IMPNIETKVLLVQIFGEKSHPIRKYQRIMYWFPKFKHVNPFPVP....QPLP.....E...DPVDLAILSLNRIAN.DLDAKT..TVYQ.LPFTDIT.ESGEEISFPHIVG........................
C3Z7S7_BRAFL/32-251                  ....................................qaallhsssq-----------HLAKKDTQENNDSRAL......VLHKQIFEDVHP.EIRTKANFLKVL.....DN..........FTK..RD.I.RRRGHVEFIYAALAKMKDFGVHKDLEVYNKIFDVFP.K.N..VFV...P......TNFI.QSLY.....N....HYPRQQETGIAILEQMEYY..G........VMPSADTADLIISVFGFRSHPMKKFRRILYWFPKFKHINPYPLP....DPLP.....A...DPVDLARLALKRMAD.DRKAEF..KVFQ.REDDETE.SS----IK-----tyvtsi..................
T1IF30_RHOPR/2-203                   .........................................fathk---------------------NDVNKE......LVQRDVFQNI--.KNKNKDTYLEML.....NI..........YKE..KE.I.KRRGHVEFIYSALKHMKEFGVEKDLDVYKSLIDVLP.K.G..KMI...P......RNMF.QAEF.....M....HYPKQQQCAIDLLEQMEEN..G........VMPDWNMEDQLVNVFGRRGYPVRRYWRMMYWMPKFKNASPWHLP....EKVP.....N...DAFQLAMLAVKRMTSvDVTSEI..SVFK.TSEVKDS.IE-----DTWIVS........................
B3LWB9_DROAN/24-240                  .......................................yakdgan-----SKQNPNP---NPRAQKQGSKNL......PAVRNPFATA--.QDRTKDSYLTMV.....EI..........FNE..RD.V.HRRNHVEFIYAALKNMADFGVERDLEVYKALINVMP.K.G..KFI...P......TNLF.QAEF.....M....HYPKQQQCIIDLLEQMEDL..G........VMPDYEMEAMLLNVFGRQGHPLRKYWRMMYWMPKFKNLSPWPLP....DPVP.....D...DTLEIARLAVERMCTvDLRSKV..TVFE.SKDLKDA.ID-----DTWIVS........................
H2M860_ORYLA/57-273                  .....................................kdprlpgrl---------------VGEDDNKRQTSL......VAHDDLFEQIAM.GAKSKATFAKVI.....DV..........FK-..RD.I.RRRGHVEFIYAALRKMPEFGVERDLGVYNRLLDVFP.K.E..VFV...P......TNFI.QRMF.....N....HYPRQQECGVQLLEQMENY..G........ITPNVETKVLLVQIFGEKSHPMRKYQRLMYWFPKFKHLNPFPIP....QQLP.....E...DPVDLARFSLTRIAN.DLDAKV..TVHQ.LPCSDVT.ESGEEIHRPYILG........................
G6D235_DANPL/1-168                   ..............................................---------------------------......------------.------------.....-M..........FED..QD.T.RRRGHVEFIYAALSRMNEFGVQKDLEVYKALVDVLP.K.G..KFI...P......VNIF.QAEF.....L....HYPKQQQCAVDLLEQMENN..G........VMPDSELEQMLLNIFGRRGIPLRKYWRMMYWMPKFKNLSPWPLP....ESLP.....D...NTLELANLAIQRITSvDPDTKI..DVWQ.TEEIEAS.ID-----KTWIV-c.......................
K7EJI1_HUMAN/1-102                   ..............................................---------------------------......------------.------------.....--..........---..--.-.---------------MREYGVERDLAVYNQLLNIFP.K.E..VFR...P......RNII.QRIF.....V....HYPRQQECGIAVLEQMENH..G........VMPNKETEFLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVP....RD--.....-...---------------.------..----.-------.-------------........................
A0A0A0MUD4_PAPAN/44-174              ...........................................saa--AHSSEQSLV--SSPPEPRQRPTKAL......VPYEDLFGQAPS.GERDKASFLQAV.....QK..........FGE..HS.L.RKRGHIDFIYLALRKMREYGVERDLAVYNQLLDIFP.K.E..VFR...P......RNVI.QRIF.....V....HYPRQQECGIAVLEQMESH..G........--------------------------------------------....----.....-...---------------.------..----.-------.-------------ea......................
W4Y8N6_STRPU/52-261                  ...................................sdipagsgisr---------------------VERNSM......VLSKTLFEEATH.DSPNKGAFKEVV.....TT..........FTE..MD.K.RRRGHVQFIETALRYMKAFGVEKDVEAYNMLLDVFP.K.G..KYV...A......KNAY.QSMF.....N....HFPEQQVCGIKVLQQMEDN..A........VLPNNNTKEILLAIFGRNAHPIKKYQRLMYWFPKFRNINPFPLP....KEMP.....S...DPIKLSEIGLKRIS-.EYEAEF..TVYS.VNRSSET.S------------vmvqdqdys...............
G1RPX7_NOMLE/44-266                  .........................................saaay----SSEQSLVP--SPPEPRQRPTKAL......VPFEDLFGQAPS.GERDKASFLQAV.....QK..........FGE..HS.V.RKRGHVDFIYLALRKMREYGVERDLAVYNQLLNIFP.K.E..VFR...P......RSII.QRIF.....V....HYPRQQECGIAVLEQMENH..G........VMPNKETEFLLIEIFGRKSYPMLKLVRLKLWFPRFMNINPFPVP....RDLP.....Q...DPVELAMFGLRHMEP.DLSARV..TIYQ.VPLPKDS.TGAADPPQPHIVG........................
M4A0F8_XIPMA/49-271                  ..........................................spas-----AKSQPEHVRFVNDDDTKKTKSL......VTQEDLFEQVAK.ESKTKATFNQVI.....DV..........FTK..RD.I.RRRGHVEFIYAALKKMPEFGVERDLTVYNKLLDVFP.K.E..VFV...P......RNFI.QRMF.....N....HYPRQQECGVQVLEQMESY..G........IMPNIETKVLLVQIFGEKSHPIRKYQRIMYWFPKFKHVNPFPIP....QPLP.....E...DAVDLAVLSLTRIAN.DLDAKT..TVYQ.LPFTDIT.ESGEEISFPHIVG........................
L8YIA6_TUPCH/35-257                  ....................................saaalssels-----------LVSRPPDPPRRPARAL......APHEELFRQAPG.EERDKASFVRAV.....RS..........FEQ..HS.V.RKRGHVDFIYLALRKMREFGVERDLAVYNLLLDIFP.K.E..VFK...P......RNVI.QRIF.....V....HYPRQQECGIAVLHQMESH..G........VMPNKETEFLLVQIFGRRSYPMLKFLRMKLWLTRFKNINPFPVP....HELP.....Q...DPVDLARLGLQHMEP.DLSARV..TVYQ.MPLSSDS.TGLADPTQPYIVG........................
G7PZF5_MACFA/44-266                  .........................................saaph----SSEQSLV--SSPPEPRQRPTKAL......VPYEDLFGQAPS.GERDKASFLQAV.....QK..........FGE..HS.V.RKRGHIDFIYLALRKMREYGVERDLAVYNKLLDIFP.K.E..VFR...P......RNVI.QRIF.....V....HYPRQQECGIAVLEQMESH..G........VMPNKETEFLLIQIFGRKSYPMLKLLRLKMWFPRFMNINPFPVP....RDLS.....Q...DPVELATFGLRHMEP.DLSARV..TIYQ.VPLPKDS.TGAADPPQPHIVG........................
F7BSY7_MACMU/44-266                  .........................................saaph----SSEQSLV--SSPPEPRQRPTKAL......VPYEDLFGQAPS.GERDKASFLQAV.....QK..........FGE..HS.V.RKRGHVDFIYLALRKMREYGVERDLAVYNQLLDIFP.K.E..VFR...P......RNVI.QRIF.....V....HYPRQQECGIAVLEQMESH..G........VMPNKETEFLLIQIFGRKSYPMLKLLRLKLWFPRFMNINPFPVP....RDLS.....Q...DPVELATFGLRHMEP.DLSARV..TIYQ.VPLPKDS.TGAADPPQPHIVG........................
G4VSP0_SCHMA/56-282                  ..............................................SQSKDSRSVPNDSEWIDAVQNVEKSELl...hlKGSDTNMTRTEI.RKWKKRTFLHIL.....EM..........FIQ..RS.GpSRKGFTSFIQNALIKMPEYEVTDDLDCYKAVIRLFP.T.G..RMT...V......KRFL.QADF.....G....HFPKQQQVMIDILNQMSRY..H........VLPDDEVGQMIIDVFGWRNHAMQTYRRLMYWMPKLYYSNPWTLPlriaDDLD.....L...DPIKLGCLIAERICP.DRMTEF..TVVQ.MPSSNS-.-------------drldslisa...............
U1MRY7_ASCSU/25-127                  .......................................wrhasss------------SSRGEKRSNNPSETR.....lQHIDEHFESIPP.EQRNKRTFNAAI.....DL..........FRL..KK.T.QTRGHVEFINSALKYLEEYGLHKDLDTYKAILNVFP.K.G..AMI...P......RNTF.Q---.....-....-------------------..-........--------------------------------------------....----.....-...---------------.------..----.-------.-------------p.......................
E5SIB9_TRISP/1-165                   ..............................................---------------------------......------------.------------.....-M..........YLR..TN.V.TRRGHTEFIYAALKRMKEI-LQTPVGNFSERKNDSP.K.-..-FH...A......IAFLrKVEG.....M....HYPKQQQCCIDVLDEMEWW..R........VYPDKEIYLIVKNAFGEWTHAMRKMKRQMYWMPKFKNADPYPLP....RPVP.....N...SDIEIAQAAMRRICR.DPANNV..EVFY.TSTVSDS.TI-----NTWIVS........................
T1J3B0_STRMM/46-261                  ...........................................rnd---QCMKIHTSCQRLAKQQSDSEQKTL......VIRGTYFESI--.KDKNRKTFQDAI.....KI..........FKN..RG.-.-RRGYVEFIYAAMAHMEEFGVQRDLETYKQLMDVFP.K.G..VLI...P......RGPW.EVEF.....M....HYPKQQYCAIDLLDDMEMN..G........VMPDRDMKDIILAAFGNKSFPIRKFMRMMYWMPKFKNLSPWPIP....FPLP.....E...APIELAKIAMRRISSvDLETEL..NVFQ.TKDLEDS.ID-----DTWIVS........................
B7PYZ8_IXOSC/41-253                  ...................................rnlhvsrshyf---------------FRKKQKVSETRL......ALREEIFKSE--.QCRDREGFIEVI.....ER..........FKL..GN.E.NRKGHVEFINVATKYLEEFNVHKDLAIYKMLFDLFP.K.G..RYP...P......KNQI.QAEF.....Q....HFPYHQDCALRLLDVMEYN..A........VVPDRELRQAVLDTFGFHSEVFKKFARMMYWMPKLKNLSPFPLP....TPLP.....R...EPLELAKLAVRRMCV.DLRTVV..SVRE.TSEVKDS.VD-----QTWVVS........................
A9V8X9_MONBE/6-206                   ...........................aargpdedpapsssadpgp--------------------ERHHQVA......GLAEAAHRQL-Q.QAQTVTELHQAI.....DA..........FRA..AE.-.PQHGHVAFLNATMERVAEIDEPLPLATYDNLLNIFP.KtN..TFK...T......SSLL.DAIW.....P....RQTLQGEAALRVLNHMETD..G........LIPQASTHAILLRTFGAASAPVKKVTYMAYWMQRFFGSNPFALP....LPLP.....Q...TDEAWLHLALRRFAG.------..----.-------.-------------kdatvhgar...............
K1PQT7_CRAGI/45-285                  kvkkkkkeeedqeidakiveekltqlekvkkpgykiriptyesttd---------------------------......RYINRIFKKAEEqGEKTEETFNTAI.....KI..........YKL..NA.GlYVRGHIEFGDLALSKLEEYELQYNLEVYKMIFSIFP.E.G..KYL...P......KSKV.DAEF.....I....PFPRQQDAALRVLTKMFDN..G........VIPDEEFGRMIISRFSQRSKVFTRFQRMLYWMPKFKHMNPWPVP....RPPP.....K...DPTQLAVMALKRMSF.DLETKI..TVVN.DPRD---.-------------scsgkfiasaqs............
B4QXL9_DROSI/27-242                  .......................................atdegnp------KQNPNPNPRA---QKPGTKNL......PALRNPFTAA--.QDRTKNSYLTMV.....EI..........FQE..RD.V.HRRNHVEFIYAALKNMADFGVERDLEVYKALINVMP.K.G..KFI...P......TNMF.QAEF.....M....HYPKQQQCIIDLLEQMEDC..G........VMPDHEMEAMLLNVFGRQGHPLRKYWRMMYWMPKFKNLSPWPLP....DPVP.....D...DTLEMAKLALERMCTvDLRSKI..TVFE.TSELKDA.ID-----DTWIVS........................
ECSIT_HUMAN/44-266                   ............................................sa-AAHSSEQSLVP--SPPEPRQRPTKAL......VPFEDLFGQAPG.GERDKASFLQTV.....QK..........FAE..HS.V.RKRGHIDFIYLALRKMREYGVERDLAVYNQLLNIFP.K.E..VFR...P......RNII.QRIF.....V....HYPRQQECGIAVLEQMENH..G........VMPNKETEFLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVP....RDLP.....Q...DPVELAMFGLRHMEP.DLSARV..TIYQ.VPLPKDS.TGAADPPQPHIVG........................
E2BJP5_HARSA/36-253                  ..........................................naih----TSECRRNDNDKDKDKKKKKSKSS......ALILHSFESV--.EHKEKEAFLDVL.....RE..........YKK..EN.E.IRRGHVEFIQVALKYMDEFGVNRDLAVYKALLDVLP.K.G..KFV...P......INYL.QTLF.....M....HYPKQQYVGIDLLCKMEDN..S........VIPDVEMQQMLLNIYGVQSIVLKKFWRMMYWMPKFSNLNPWPCS....RPAP.....K...DPRVLARIAVNKLSSiDVTSIV..TEYR.TKDVEDS.TE-----DTWIL-s.......................
M3W343_FELCA/45-268                  ............................................aa--THSSDSWLVP--PPPKPPRGPTRAL......APHEELFRRAPD.GAQDKANFVRAV.....QT..........FGQ..HN.V.HKRGHVDFIYLALRKMREYGVERDLAVYNLLLDVFP.K.E..VFR...P......RSVF.QRIF.....I....HYPRQQECGIAVLEQMENHdtG........VMPNKETEFLLIQIFGRKSYPMLKFVRMKLWFSRFKNINPFPLP....RDLP.....Q...DPVDLAKLGLRHMEP.NLSARV..TIYQ.MPSAKDS.TGAADATESHIVG........................
A8WQY1_CAEBR/5-221                   ...............................qlskriitaqirslt-------------------NTSQEAGL......VHVEKQFEAVVP.EKRDKDAFMAAI.....AT..........FKE..KR.-.-GRTHVEFINTALKYVKDYRVHKDLDTYKSLLDVFP.K.G..KMI...P......QTAF.QKVF.....L....HYPQQQNCAVKVLDEMEWH..G........VQPDKEIHDIVVNAFGEWNFATKKVKRMLYWMPKLKHSNKYLDR....RHLE.....GkslSPSELAGIALKMMSR.DPATSI..SLLK.LSDNSDP.VD-----------kwfatsq.................
B4G354_DROPE/32-249                  ..................................nysadetnsnsg------------NPNAKRAGTGGSKSL......PAVRNVFAAA--.QDKTKDTYLTMV.....EI..........FQE..RD.V.HRRNHVEFIYAALKHMPDFGVENDLEVYKALINVMP.K.G..KFI...P......TNLF.QAEF.....M....HYPKQQQCIIDLLEQMEDF..G........VMPDYEMEAMLLNVFGNKGHPLRKYWRMMYWMPKFKNLSPWPLP....NPVP.....D...DTLEIAKLAVERMCTvDLRSQI..NVFD.TKELKDA.VD-----ETWIVS........................
J9K9S4_ACYPI/16-231                  ............................nrqsiksvqrgfhstepc-------------------LDKPPKVD......VVSVDSFNNV--.KEKNKKTFLDML.....KV..........YRM..EK.-.YRSGHVEFINKAIKHLDEFGVNEDLETYKKLIQVLP.A.G..KFV...P......QNYI.QSEF.....M....HYPKHQQCIIDLLQKMEDN..G........VIPDWEVEDMLVKRFGPRGFPVRRYWRMMYWMPKFNNLSPWPIP....KPAP.....N...DPYELALLAIKRISSiDIESEV..KVYK.TKELEES.IE-----DTWIVS........................
Q7QI51_ANOGA/26-242                  ........................................rqcstk-------RNEETADGKPEDGGGKQGSL......IVRTNLFESA--.AKKDKQTYIEMV.....KI..........FEK..RS.V.HRRNHVEFIYAALRHMEEFGVNKDIAVYKALIDVMP.K.G..KFI...P......TNIF.QAEF.....M....HYPRQQQCIIDLLEQMEDN..G........VMPDYEMEAMLVNVFGKKGHPVRKYWRMMYWMPKFKNLSPWLLP....NPVP.....D...DALELARLAVERMCSiDPRSKI..QVFD.TQEVESA.ID-----HTWVVS........................
E9HFW4_DAPPU/30-241                  ..................................qsrhihinslhf-------------------KNKEPNEL......IVSPSMFY-VPE.GDRNKDTFLEAV.....KI..........YTT..RP.G.PRRAQVEFIYAALKEMEEFGVHRDLEAYKDIIDILP.K.G..KYI...P......TNMF.QAEF.....M....HYPKQQQCIIDVLEQMENN..G........VCPDKETDQMVLNIFGRHGAPTKKLRRMAYWMPKFKNQSPWALP....QKIP.....N...SNLEIAKLAVQRMGSvDPATEM..NIFQ.TSELQDA.ID-----DTWIV-n.......................
T1G2K8_HELRO/1-161                   .............................................i---------------------------......------------.------------.....--..........---..--.-.SRRGHVEFLYAALKRMSDFNAHQDIETYKKLLSVFP.K.Y..KMI...P......KNVW.QVEF.....M....HYPKQQQCCIDILDYMESQ..G........VVPDDDLGYQLRDLFGQNSHVFRKYRRMMFWMPKFKFQNPYYVP....YELP.....S...NHIELARMALKRMSV.DLATEI..SVFH.TEDIATS.ND-----KTFIVS........................
A0A068X7Y8_HYMMI/165-399             ................tdsktesetshaellwseasktfiqdklvk------------------------SST......SPVERTLKHSQI.KAIKKAAFLDTV.....EL..........YKA..RS.GaPRQGFNEFILAALKQMKDYEVADDLEAYKALLSVLP.R.G.gRLK...A......KTFL.HADM.....G....AFKQQQDTVTRLLMQLNAN..Q........VMPDDDVGNTIVEVFGFRSYVMTQYRRIMYWVPKFRHANPWPVI....EHLPddldgE...DAIRLAHLAAARICP.DPNTEFftTVLN.EEDEK--.-------------sapeipsiivg.............
H2U7Y8_TAKRU/10-230                  ........................................vcakrn---------SVPSAQPLNEDKKSNDSA......LIHADLFDHVSG.TFKTKATFNKAI.....DV..........FIK..SD.V.RRRGHVEFIYAALKKMPEFGVERDLAVYNKLLDVFP.K.G..VFV...P......RNFI.QRMF.....N....HYPRQQECGVQILEQMENY..G........IMPNLETKVLLVQIFGEKGHPVRKYQRIMYWFPKFKELNPWPIP....KDLP.....T...DPVDLARFSLARIAD.DLDAQV..TVYQ.VPHTDVT.EKGEHVTLPHIVG........................
Q9N580_CAEEL/5-222                   ..............................hvsrrvisnqircfaa--------------------ANQETSL......VHVEKQFEAIEP.EKRDKDAFMAAI.....AT..........FKE..KR.-.-GRTHVEFINTALKYVKEYGVHKDIDTYKGLLEVFP.K.G..KMI...P......QTVF.QKVF.....L....HYPQQQNCAVKVLDEMEWH..G........VQPDKEIHDIVVNAFGEWNFATKKVKRMLYWMPKLKHSNKYLDR....RHVE.....GkslSPSELAGIALKMMSR.DAASSI..SLLK.LSDSSDP.QQ-----------kwlatsqs................
F6X0J0_CALJA/44-266                  ...........................................saa--THSSETALVP--TPTEPQQRRTKAV......VPYENMFGQAPN.GKRDKASFLQAV.....QK..........FGE..HS.V.RKRGHVDFIYLALRKMREYGVERDLAVYNQLLDIFP.K.E..VFR...P......RNFI.QHIF.....I....HYPRQQQCGVAVLEQMENH..G........VMPNKETEFLLIQIFGRKSHPMLKFLRLKRWFPRFMNINPFPVP....RDLS.....Q...DPVDLATFALRRIEP.DLSARV..TVYQ.VASSKDS.TDVADPTQPHIIG........................
G1SLP7_RABIT/45-266                  ......................................aaacssdl--------SLVP--SPPESQRRPVKVL......EPHEELFKQAPG.GERDKASFVRAV.....QC..........FGQ..QD.V.RRRGHVDFIYLALRKMREFGVQRDLAVYNLLLDVFP.K.E..VFR...P......RNVF.QRMF.....V....HYPRQQECGVAVLEQMEQH..G........VMPDTQTEFLLTQIFGRRSYPMLKLVRMKLWLTRFKNVNPFPVP....LHLP.....P...DPVDLAKLGLRHMEP.DLSARV..TVYQ.MSLPSDP.ASPEEPAQPHIVG........................
K7EN32_HUMAN/1-150                   ..............................................---------------------------......------------.------------.....--..........---..--.-.---------------MREYGVERDLAVYNQLLNIFP.K.E..VFR...P......RNII.QRIF.....V....HYPRQQECGIAVLEQMENH..G........VMPNKETEFLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVP....RDLP.....Q...DPVELAMFGLRHMEP.DLSARV..TIYQ.VPLPKDS.TGAADPPQPHIVG........................
F8W5R4_DANRE/56-139                  ...........................................vcs---TDRQNRTDIEKLVEDETHHKDKTL......VTHDDIFDRAAG.DSKTKVEFNRVV.....DV..........FKS..KD.I.RRRGHVEFIYAALKKMPEFGVECDV-----------.-.-..---...-......----.----.....-....-------------------..-........--------------------------------------------....----.....-...---------------.------..----.-------.-------------........................
G3VS11_SARHA/52-270                  .............................arrltsdsdpvpmvrpp--------------------AVSTKAL......EPYEDFFEQATG.GQRDKTGFSRAV.....KA..........FAQ..RD.V.RKRGHVDFIYLALRKMPEYGVERDLAIYNILLDIFP.K.E..VFV...P......QNVL.QQIF.....N....HYPRQQECGVKVLDQMENY..G........VMPNKETEFLLLQIFGRKSHPMLKYLRLTYWFLRFKNINPFPVP....KPLP.....K...DPVDLARHSLERIAA.DLSAKV..TVYQ.MPGPEDL.G--ADPSQPHIVG........................
F7BSY0_MACMU/44-266                  .........................................saaph----SSEQSLV--SSPPEPRQRPTKAL......VPYEDLFGQAPS.GERDKASFLQAV.....QK..........FGE..HS.V.RKRGHVDFIYLALRKMREYGVERDLAVYNQLLDIFP.K.E..VFR...P......RNVI.QRIF.....V....HYPRQQECGIAVLEQMESH..G........VMPNKETEFLLIQIFGRKSYPMLKLLRLKLWFPRFMNINPFPVP....RDLS.....Q...DPVELATFGLRHMEP.DLSARV..TIYQ.VPLPKDS.TGAADPPQPHIVG........................
F6TG92_XENTR/31-260                  ......................naqkqvtcclhtspppgppqatss-----------------------AGSV......TPYEDVFQRE--.-QRNKASFVEVL.....DL..........YCN..RD.V.RRRGHVEIIEAALRWMTEFGVEKDLEVYNKLLDVFP.K.E..VFV...P......QNYI.QRMF.....N....HYPRQQECAIRVLEQMENY..GkepttyysITPNKQTCFLLLQIFGARSHPIRKYQRMMYWFPRFKHTNPFPVP....AELP.....A...DPVELSRMCLHRIAN.DLDSRV..AVYQ.MPYTEKC.DDGKEREHLHVVG........................
V3Z2D1_LOTGI/1-183                   .............................................q---------------------------......------------.DKVDKKDFRKAV.....DI..........YLK..KE.SlYRRGSVEFINSALKQMKKYDAHRDLMSYKVLISVFP.K.D..KMK...P......LSSW.QSEM.....M....HYPKQQQCGIDIMEQMERN..G........IIPDQQFGDLLYDRFGETSHVFRKYQRMAYWLPKIKNANPYPVP....DTFP.....D...CRIELAKLALNRMCI.DYHNKI..TVWE.THDKEEE.AT----QN-----tfias...................
B4NHG1_DROWI/26-244                  ...........................antnsssgagnsssrgagg------------------TKNATTSRL......PAIRNPFAAA--.QEKTKNTYLTMV.....EI..........FQE..RD.V.HRRNHVEFIYAALKHMPDFGVEHDLEVYKALIDVMP.K.G..KFI...P......TNIF.QAEF.....M....HYPKQQQCIIDLLEQMEDF..G........VMPDYEMEAMLLNVFGNKGHPLRKYWRMMYWMPKFKNLSPWPLP....DPVP.....D...DTLEIAKLAVERMCTvDLRSQL..RVYE.TSELKDA.LD-----ETWIVS........................
W5JEM5_ANODA/23-236                  .....................................asftrqcst-------------KPEAEQGDSEEKSV......ILRTNLFETT--.KNKDKHTYLEMV.....KI..........FES..RS.V.HRRNHVEFIYAALKHMEAFGVHKDLAVYKALIDVMP.K.G..KFV...P......TNLF.QAEF.....M....HYPRQQQCIIDLLEQMEDN..G........VMPDYEMEAMLVNVFGRKGHPVRKYWRMMYWMPKFKNLSPWLLP....NPVP.....N...DALELARLAVERMCSvDPRSKI..DVFD.TKTVEDA.ID-----HTWIVS........................
E3M651_CAERE/9-222                   .............................hfnlissrslstvnqdf-------------------------GL......VHVEKQFEAIEP.KKRDKDAFMAAI.....GT..........FKE..KR.-.-GRTHVEFINTALKYVKDYGVHKDLETYKSLLDVFP.K.G..KMI...P......QTVF.QKVF.....L....HYPQQQNCAVKVLDEMEWH..G........VQPDKEIHDIVVNAFGEWNFATKKVKRMLYWMPKLKHSNKYLDRr.svEGLS.....L...TPSELAGIALKMMNR.DPATSI..SLLK.FSDSSDP.KD-----------kwmataqs................
ECSIT_XENTR/31-252                   ......................naqkqvtcclhtspppgppqatss-----------------------AGSV......TPYEDVFQRE--.-QRNKASFVEVL.....DL..........YCN..RD.V.RRRGHVEIIEAALRWMTEFGVEKDLEVYNKLLDVFP.K.E..VFV...P......QNYI.QRMF.....N....HYPRQQECAIRVLEQMENY..G........ITPNKQTCFLLLQIFGARSHPIRKYQRMMYWFPRFKHTNPFPVP....AELP.....A...DPVELSRMCLHRIAN.DLDSRV..AVYQ.MPYTEKC.DDGKEREHLHVVG........................
J3KTF5_HUMAN/1-150                   ..............................................---------------------------......------------.------------.....--..........---..--.-.---------------MREYGVERDLAVYNQLLNIFP.K.E..VFR...P......RNII.QRIF.....V....HYPRQQECGIAVLEQMENH..G........VMPNKETEFLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVP....RDLP.....Q...DPVELAMFGLRHMEP.DLSARV..TIYQ.VPLPKDS.TGAADPPQPHIVG........................
F2TZC5_SALR5/121-311                 .......................aplppevearvrdvlggtstrel---------------------------......-------AQVVQ.LAQDEEQLFSIV.....DV..........IVQ..NQ.-.PARGHVKFINAVLNRMDELNADVEVHFYNRLLEVFPvT.N..TYK...T......KSLL.DAVW.....P....RPSLQVDAALKVLNRMENE..G........VMPNGHTFHSLMEVFGRASQPIKKVRSMGYWMRYFMDSNPFSIS....-MLP.....E...---------------.------..----.-------.-------------rprnerafmhytaqriggeattst
H0W0W4_CAVPO/13-235                  ......................................sssplssv---------KAPVPRPPEPGKKPGEVR......APHEELFQPAPG.GARDKASFALAV.....QN..........FGR..HS.V.RKRGHVDFIYLALRKMPEFGVERDLAAYNLLLDVFP.K.E..VFR...P......RSAF.QRIF.....T....HYPRQQECGVAVLEQMERH..G........VMPNKETEFLLLQIFGRGSHPMLKYVRMRLWLTRFQNINPFPLP....HELP.....Q...DVVELATLGLRRVEP.DLSARV..TVYQ.KSLPADT.TDPVDPIQPHIVG........................
A0A044T7Z7_ONCVO/21-236              ......................................vqyliyrf---------------ASESSQKIRKEL......LPSEQSFSEVAN.ELRSKQTFLNVI.....DN..........FCK..KQ.V.HARGHVEFINTALKYMKEYGLQKDLDIYKSLLNVFP.K.G..PMI...P......QNVF.QQRF.....L....YYPQQQICCVKLLDEMEWF..G........VQPDKEIHDLVVNAFGEWNYATKKVKRMMYWMPKLKHSNIYLDR....RKIEg..knL...SAVDLGYLALKMISR.DPGTRI..TLVR.INDTKLD.-------------esdrwllss...............
A0A0B2VLD0_TOXCA/34-253              ................................tsiwrttlstsasd----------------RKQSDTFETGL......QHIDEHFEAIPP.KQRNKTTFNTAI.....EL..........FRQ..KK.S.ATRGHVEFINSALKYLEEYGLHKDLDTYKALLNVFP.K.G..AMI...P......RNAF.QKIF.....L....HYPMQQNCCVKVLDQMEWF..G........VQPDKEVHDIVANAFGEWNFATRKIKRMLYWMPKLKHSNKYLDR....RCLEg..rqV...GPVELAFIALKMMAR.DPGTAF..SLVK.IKDLKLA.ES-----------krwlvs..................
ECSIT_DROME/27-242                   .......................................atdegnp------KQNPNPNPRA---QKPGTKNL......PALRNPFAAA--.QDRTKNSYLTMV.....EI..........FQE..RD.V.HRRNHVEFIYAALKNMADFGVERDLEVYKALINVMP.K.G..KFI...P......TNMF.QAEF.....M....HYPKQQQCIIDLLEQMEDC..G........VMPDHEMEAMLLNVFGRQGHPLRKYWRMMYWMPKFKNLSPWPLP....DPVP.....D...DTLEMAKLALERMCTvDLRSKI..TVFE.TSELKDA.ID-----DTWIVS........................
G3H694_CRIGR/45-265                  ...................................avihkddvslv-------------PRPPEPQRKPIKVP......VLHEELFTPSAT.GEKDKASFLRAL.....RS..........FEE..HS.V.RKRGHVDFIYLALRKMPEFGVERDLSVYNLLLDVFP.K.E..IFR...P......RNII.QRIF.....V....HYPRQQECGISVLEQMERY..G........VMPNTETEFLLTQIFGRTSYPMLKFLRMKLWLTRFKNINPYPVP....RDLP.....Q...DPLDLAKLSLRRMEP.DLSAKV..TVYQ.MSLPSDS.TG-TDPIQPHIVG........................
I3M2P2_SPETR/44-266                  ...........................................sta--THNSEMSLVP--HPPEPPKKPIKAP......APHEELFRQEPG.GERDKASFVRAV.....QN..........FGQ..YN.V.RKRGHVDFIYLALRKMREYGVERDLTVYNLLLDIFP.K.E..VFR...P......RSVI.QRIF.....L....HYPRQQECGIAVLEQMENH..G........VMPNKETEFLLIQIFGRKSYPMLKYLRMRLWLTRFKNINPFPVP....RDLP.....Q...DPVDLAKLGLRHIEP.DLSARI..TVYQ.MPLSDDL.TGTEDPIQPHIVG........................
Q17B53_AEDAE/23-247                  ...............................ctkdtkggphhrpee--------AEGDTENDHHQRKSSETRV......ALRTPLFEHV--.STKDKKTYIEMV.....RV..........FEG..RS.V.HRRNHVEFIYAALKHMEEFGVHKDLEVYKSLINVMP.K.G..KFI...P......TNIF.QAEF.....M....HYPRQQQVIIDLLEQMEDN..G........VIPDYEMESMLVNVFGKKGHPVRKYWRMMYWMPKFKNLSPWPLP....NPVP.....D...DSLDLAKMAVERMCSvDLLSQI..TLFD.TENVPDA.ID-----HTWIVS........................
H2XTD8_CIOIN/1-187                   ..............................................---------------------------......------------.----KRTFYKLV.....DI..........WIS..EA.GlARRGHREFIQAAMHAMPKFNVESDIRAYVRLLDCFP.D.G..KHTgihR......SHWF.YSAF.....Q....DKIADHSIAENLVSQISQH..G........AIPNDKLFNKALEIFGKFSPAMLAVRQCLFWYPRIIAFQKHPISv..sDFKE.....L...SPTEIAFHGLRQMSP.GLDAKF..RNFE.VLQSEC-.-------------deilntdqldsvvs..........
A0A067QJH9_ZOONE/45-252              ................................thrrlihlhkclna------------------------EKS......LVTKDFFESI--.QDKSKETFLDMI.....HI..........FES..RD.I.HRRGHVEFIYAALRHMEEFGVNKDLEVYKSLIDILP.K.G..KYI...P......TNIF.QAEF.....Q....HYPKQQQCIIDVLEQMEDH..G........VTPDVEMENLLLNIFGKRGHPVRKYWRMMYWMPKFKNISPWPLP....NPVP.....N...NSLELAKMAMERMSSvDLQSKV..SVYQ.ASDLKDS.LD-----DTWI--as......................
H0WVJ4_OTOGA/44-266                  ..........................................saaa---HNSELSLVP--GPPEPQRRPIRAL......APHEDLFRQAPG.GERDKASFVRAV.....QS..........FGQ..RN.V.RKRGHVDFIYLALRKMREYGVERDVAVYNLLLDVFP.K.E..VFR...P......RNVI.QRIF.....V....HYPRQQECGIAVLEQMENN..G........VMPNKETEFLLIQIFGRKSYPMLKYLRMKLWFPRFKNINPFPIP....RDLP.....Q...DPVDLAQLGLRHMEP.DLGAKV..TIYQ.MPVSNDW.TGASDPTEPHIVG........................
J3KMM6_MOUSE/1-196                   ..............................................---------------------------......-MHEDSFKPSGN.RERDKASFLNAV.....RS..........FGA..HN.V.RKRGHVDFIYLALRKMPEFGVERDLSVYNLLLDVFP.K.E..VFR...P......RNVI.QRIF.....V....HYPRQQECGVAVLEQMERH..G........VMPSAETEFLLIQIFGRKSYPMLKFLRMKLWFTRFKNINPYPVP....RDLP.....Q...DPLDLAKLGLRHMEP.DLSAKV..TVYQ.MSLPSDS.TGMEDPTQPHIVG........................
A8PQM3_BRUMA/18-235                  .....................................ckpvcqayr--------------FASENNETIRKKL......LPSEQRFDEVVI.ELRSKQTFLNVI.....DN..........FCK..KQ.T.HARGHVEFINAALKYMKEYGLQKDLDIYKALLNIFP.K.G..PMI...P......TNVF.QQRF.....L....YYPQQQICCIKLLDEMEWF..G........VQPDKEIHDLVVNAFGEWNYASKKMKRMMYWMPKLKHSNGYLDR....RKIQg..kkL...SAVDFGYLALKMISR.DPGTRI..TLVE.MNDTELN.ES-----------drwllsa.................
M3Y0V6_MUSPF/47-269                  .......................................ataagss------DSWLAP--PPPEPQKEPTKAL......AFHEELFQRAPE.GTRDKADFVRAV.....QN..........FGQ..HN.V.HKRGHVDFIYLALRKMREFGVERDLAVYNLLLDVFP.K.E..VFR...P......RSIF.QKMF.....I....HYPRQQECGVAVLEQMENH..G........VMPNKETEFLLLQIFGRKSYPMLKFVRMKLWFSRFKNINPFPVP....RDLP.....Q...DPVDLAKLGLRHMEP.NLNATV..TIYQ.MPSSTDT.TGAADPAEPHIVG........................
F7FTB5_MONDO/50-270                  ...................................sstarqtsdse---------PLP---MVKPPGMPTKTL......EPYEDFFEQASG.GKRDKSGFSKAV.....KT..........FAQ..RD.I.RKRGHVDFIYLALRKMPEYGVEHDLAIYNLLLDIFP.K.E..VFV...P......RNVL.QQIF.....N....HYPRQQECGVKVLDQMENF..G........VLPNKETEFLLLQIFGRKSHPMRKYLRLMYWLPRFKNINPFPLP....RPLP.....K...DPVDLARHGLERIAA.DLSARI..TVYQ.MPEPEDL.--GVDPPQPHIVG........................
A0A091E148_FUKDA/46-269              .........................................aphts---EKSEKSLV--PRPPESGKRLAKVP......APWEDLFHPAPG.GTRDKASFVRAV.....QS..........FEQ..HN.V.HKRGHVDFIYLALRKMREYGVERDLAAYNLLLDIFP.K.E..VFR...P......RNFI.QQIF.....L....HYPRQQECGVAVLDQMESN..G........VMPNKETKFLLLQIFGRGSHPMLKLERMRLWFTRFQHINPFPVP....RDLP.....H...GAVELATLGLQHMEP.DLSARV..TVYQ.RPLPDDV.TDPGDLIQPHIVG........................
G7YTU4_CLOSI/249-431                 .........................................tiqge---------------------------......------------.---------HAI.....NV..........YLE..RY.GkTRRGFNQFALNALDKMPEYEVTDDLDCYKAILRVFP.P.G..RMV...V......TSFL.QAEW.....N....HFPRQQDTVIKLLQQMSKH..H........VIPDDEVGQMIIDIFGWRCHAMTHYRHLMYWVPKLAHANPWPVAqhilDDLD.....E...DPLHLARLIAERICS.DPMAEL..RLVR.LSDSKCD.NS-----------qqpssmis................
U4UCT0_DENPD/1-208                   ............................................ms-------------HRKDKEQTKEDKTS......VTIRDGFQEV--.RDKNKDTYLQMI.....NI..........YID..KEhV.YRRGHVEFIYAALKHMKEFGVHRDLEVYRTLIDVLP.K.G..KFV...A......QNLI.QAEF.....M....HYPKQQQCIIDLLSQMEEN..N........VLPDFDMEDQLVAIFGRRAFPVRRYWRMMYWMPKWRYASPFPLP....DPLP.....K...DTYELAKLAIERISNvDPTNQV..TIYQ.TADIKDS.VD-----DTWIIS........................
W4WM45_ATTCE/28-242                  ......................................rslsraih---------TSQERCKKDEKDSKPSG-......-LVLHVFANA--.ESRERKAYLDIL.....RE..........YKT..NN.E.MRRGHVEFIQVALKYMDEFGVNRDLAVYKAVLDVLP.K.G..KFV...P......RNYF.QTIF.....M....HYPKQQHVAIDLLCKMEHN..C........VIPDLEMQEMLLNIFGMQALVLKKFWRMMYWMPKFANLNPWPCP....TPVP.....K...DPKVLAKLAMNKISSiDVQTEI..TEFK.TKDVEDA.ID-----DTWIVS........................
G1KTD3_ANOCA/53-274                  .......................................stclgtt---------TAPKDNPDNSKESTNRSL......VTVEELFERTSV.DAKNRASFQQAV.....NI..........FSQ..RD.I.RRRGHVEFIYAALKKMPEFGVEKDIDVYNKILDVFP.K.E..VFV...P......HNFI.QRMF.....N....HYPRQQECAIEVLEQMENY..G........VMPNKETKLLLLQIFGNKSHPMRKYQRLMYWFPKFKHINPYPVP....DLLP.....R...DPVDLARLSLQRIAA.DLDARV..TVYQ.LSHVEIT.DSGKSIDHPHIVG........................
W5QB33_SHEEP/45-266                  ............................................aa--AHNPDSSLVP--RPPEPPRRPVKAL......AVHEELFRPALD.GARNKANFVRAV.....QN..........FAE..YN.V.HKRGHVDFIYLALRKMREYGVERDLSVYNLLLDVFP.K.E..VFR...P......RNIF.HSIF.....L....HYPRQQECGIAVLEQMENH..G........VMPNKETEFLLLQIFGRKSYPMLKLVRMKLWFTRFKNINPFPVP....RDLP.....Q...DPVDLASLALRHMEP.DLSARV..TTYQ.MPLPKDS.PDAMDPTETHIVG........................
K7IYE0_NASVI/45-280                  ................................tdknnetqkdsqer--SDQNQEKPKEESRSEDEKDDKRKGRssvfakALVLHAFENA--.RKKEKETFLECL.....RM..........YQN..QP.G.IKQERVPFIYTALKYMEEFGVHKDLSVYKQLIDIFP.K.Q..KMI...P......SNLF.QGMF.....L....YYPKEQYCATAVLEQMEDN..G........VIPDPEMELMLLNIFGRHGMPLEKYWKMMYWQPKFKNLNPWPVP....QPIP.....T...DLRELAWYAMNKISSiDVRSVV..TDFN.TEDVPDS.ID-----KTWIVS........................
E9ICX0_SOLIN/32-245                  .......................................sriihis-----------SQQRTKNKEDDKDSKT......SLVLHAFENV--.GKKEKQAYLDII.....RE..........YKS..KN.E.KRHGHVEFIQVALKYMDEFGVNRDLAVYKSLVDVLP.K.G..KFI...P......RNFY.QTMF.....M....HYPKQQYVTVDLLCKMEHN..C........VLPDLEMQEILLNIFGKHGLPLKKFWRMMYWMPKFANLNPWPCP....RPAP.....R...DPRELARLAMSKISSvDVQTSI..TDFD.TKDVEDA.IE-----NTWIVS........................
L5L303_PTEAL/79-301                  ...........................................sst--THKSDSSLVP--HPPEPPRRPARAL......APHEELFRQAPD.GARDKASFVQAM.....QN..........FGQ..HN.V.HKRGHVDFIYLALRKMREYGVEQDLAVYNLLLDIFP.K.D..VFR...P......RSIF.QKIF.....I....HYPRQQECGIAILEQMENH..G........VMPNKETEFLLLQIFGRKSYPMLKFVRMRLWFSGFKNVNPFPMP....QDLP.....Q...DPVDLARLGLRHMEP.DLSARV..TVYQ.MPSSKDS.TGTADPTEPHIVG........................
H3BCG7_LATCH/56-279                  ..........................................spqa---ASSEPAPS-AESKDQERGPRDKSL......VTYDDLFKKAAG.DSRTKATFNRVV.....DT..........FCN..KN.V.RRRGHVEFIYAALKKMPEFGVERDINIYNRILDVFP.K.E..VFV...P......QNFI.QRMF.....N....HYPRQQECGVQVLEQMENY..G........IMPNKETKFLLVQIFGEKSHPVRKYQRIMYWFPKFKHANPYPVP....AVLP.....Q...DPLDLAKFSLQRIAA.DLDAKT..TVFQ.MPATDIS.EDGAEVKQPYVVG........................
U1MRY7_ASCSU/125-217                 ............................................fq---------------------------......------------.------------.....--..........---..--.-.------------------------------------.-.-..---...-......----.----.....-....-------------------..-........--PDKEVHDIVANAFGEWNFATKKIKRMLYWMPKLKHSNKYLDR....RSIE.....GrevGAVELAFIALKMMAR.DPGTAF..SYVT.VKDCEL-.-------------peserwmvsa..............
K7EPL5_HUMAN/44-227                  ............................................sa-AAHSSEQSLVP--SPPEPRQRPTKAL......VPFEDLFGQAPG.GERDKASFLQTV.....QK..........FAE..HS.V.RKRGHIDFIYLALRKMREYGVERDLAVYNQLLNIFP.K.E..VFR...P......RNII.QRIF.....V....HYPRQQECGIAVLEQMENH..G........VMPNKETEFLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVP....RDLP.....Q...DPVELA---------.------..----.-------.-------------........................
B4MC61_DROVI/252-471                 ........................................yatdea----NENANTDDAKSSKKNNAGTSRSL......PAIRNPFTAA--.QEKTKNSYLTMV.....EI..........FAE..RD.V.HRRNHVEFIYAALKHMPDFGVEHDLEVYKALIDVMP.K.G..KFI...P......TNLF.QAEF.....M....HYPKQQQCIIDLLEQMEDY..G........VMPDYEMEAMLLNVFGNKGHPLRKYWRMMYWMPKFKNLSPWPLP....DPVP.....D...DTLEIAKLAVERMCTvDLRSKV..EVFQ.ASEVKDS.LD-----DTWIVS........................
G3UEA5_LOXAF/14-237                  ...........................................aat---HSSDSDSSVVPRPPEPSRWPMKGL......APHQELFGQAPS.GERDKASFVQAV.....QN..........FKQ..HS.V.RRRGHVDFIYLALRQMRQYGVERDLAVYNLLLDIFP.K.E..VFR...P......RSII.QYIF.....V....HYPRQQECGLAILEQMENH..G........VMPNKETEFLLIQIFGHKSYPMLKFLRMKLWFSRFKNINPFPVP....QDLP.....Q...DPVDLAKLGLRHMEP.DLSARV..TIYQ.MPLSKDS.TGAADPTQPHIVG........................
B3RPX5_TRIAD/54-259                  ....................................sapiivkrfk-------------------SNDKIKNL......ITVGAILEEA-L.QTKQKDSFHQAI.....DK..........FNA..RD.R.QRRGHVDFIYSALSLIDKFELEQDIETYNKLLDVFP.K.D..RFV...N......RSWL.DVVW.....P....KPHPQIDCALDVLTKMEEE..G........ILPNEDTYRILYDVFGRKSFPLQKAQRIEYWFTRFKDINPYKLP....SPVP.....T...DPIELGSIALQRIAG.-SDGVI..TIYE.HDKKN--.-------------gedkflla................
E1FZ24_LOALO/23-240                  .....................................kpvqslayr--------------FASESNEKFGKEL......LPSEKRFDEVAI.ELRTKQTFLNVI.....DN..........FCK..KQ.M.HARGHVEFINSALKYMKEYGLQKDLDIYKSLLNIFP.K.G..PMI...P......TNVF.QRRF.....L....YFPQQQICCVKLLDEMEWF..G........VQPDKEIHDLVVNAFGEWNYATKKVKRMLYWMPKLKHSNTYLDR....RKIEg..kkL...SAVDLGYLALKMISR.DPGTRI..TLVG.INDTELS.ES-----------drwllsa.................
I1FRG8_AMPQE/1-166                   ..........................................msym---------------------------......------------.------------.....--..........--S..LE.K.NRSGHMKFIKEGLSRMDEFGLQKDLLSYNRLLDLFP.K.G..RFN...N......KSFF.DTLW.....P....KPHPQIDLALEILSKMEDN..G........IRPDNVTYTILCETFSRISLPVQKCERIAFWFDKFEDIDPYRIK....GDMP.....T...DLYTLSKMALQRISGeD-----..----.-------.-------------ckvwnikeaegegdtdsfvia...
A0A0D2VSR5_CAPO3/106-322             .....................galasaslsssssspsssssapais---------------------------......--AGHLMRHM-G.AASNLAQIEAVV.....DA..........FRE..LK.-.SVRGSVEFIEAAITRLDALDLDIPKRTYDKLLDVFP.K.N..HTV...T......RSWL.DVMW.....P....RENAAVETALKLLQRMEDA..S........ICPDLETFKPVFYAFGKKSVPVRKCESMYYWMTLFG-MNPKSKSy.qiKALP.....E...DLTLVTQLALNRLVG.VSDAQI..H---.-------.-------------qhgvfqrdgngavdvghvdh....
A0A0D9R327_CHLSB/13-235              ...........................................ssa--AHSSEQSLV--SSPPEPRQRPTKAL......VPYEDLFGQAPN.GERDKASFLQAV.....QK..........FGE..HS.V.RKRGHVDFIYLALRKMREYGVERDLAVYNQLLDIFP.K.E..VFR...P......RNVI.QRIF.....V....HYPRQQECGIAVLEQMESH..G........VMPNKETEFLLIQIFGRKSYPMLKLLRLKLWFPRFMNINPFPVP....RDLS.....Q...DPVELATFGLRHMEP.DLSARV..TIYQ.VPLPKDS.TGAAHPPQPHIVG........................
H3CG44_TETNG/55-277                  .........................................spaca----KKTSVPA-AELFNEDKTKNSSAL......-AHVDLFDHVAG.EFKTKAMFNKAI.....DV..........YVK..SD.V.RRRGHVEFIYAALKRMPEFGVERDLAVYNKLLDVFP.K.E..VFV...P......RNFI.QRMF.....N....HYPRQQECGVQILEQMENY..G........IMPNVETKVLLVQIFGEKSHPMRKYQRILYWFPKFKHLNPFPVP....QELP.....A...DPVDLARFSLTRIAD.DLDAEV..TVYQ.VTSTDVS.ESGEHVSLPHIV-e.......................
L5LRL6_MYODS/69-290                  ...........................................vat---HSSDSSLVP--RPPEPLRQPAKPL......SPHEELFRPAPD.GARDKASFVRAV.....QN..........FGQ..HN.V.HKRGHVDFIYLALRKMRDYGVEKDLAVYNLLLDVFP.K.E..VFR...P......RNVF.QKIF.....I....HYPRQQECGLAVLEQMENH..G........VMPNKETEFLLVQIFGRKSYPMLKFVRMKLWFSRFKNINPFPVP....RDLP.....K...DPVDLAMLGLRHIEP.DLSARV..TVYQ.MASSRDS.TGTADPTEQHIVG........................
ECSIT_DANRE/56-279                   ...........................................vcs---TDRQNRTDIEKLVEDETHHKDKTL......VTHDDIFDRAAG.DSKTKVEFNRVV.....DV..........FKS..KD.I.RRRGHVEFIYAALKKMPEFGVECDVTVYNKLLDVFP.K.E..VFV...P......QNFI.QRMF.....N....HYPRQQECGVQVLEQMENY..G........VMPNIETKVLLVQIFGEKSHPIRKFQRIMYWFPKFKHTNPYPVP....HVLP.....S...DPVDLAQFSLTRIAA.DLDAKI..TIYQ.YPSTDIT.ETGEEITRPHIVG........................
K7EJG5_HUMAN/1-53                    .............................................x---------------------------......------------.------------.....--..........---..--.-.------------------------------------.-.-..---...-......----.----.....-....-------------------..-........-------------------------------------VNPFPVP....RDLP.....Q...DPVELAMFGLRHMEP.DLSARV..TIYQ.APCA---.-------------apdaarlppqr.............
F6YXE5_HORSE/45-266                  ............................................ta--AHHSDSSLVP--RPPEPPRRPAKAL......ALHEELFRQAPD.GARDKASFVQAV.....QK..........FGQ..HN.V.HRRGHVDFIYLALRKMREYGVERDLAVYNLLLDVFP.K.E..VFR...P......RSVL.HSIF.....I....HYPRQQECGIAVLEQMENH..G........VMPNKETEFLLLQIFGRKSYPMLKFLRMKLWFSRFKNINPFPVP....RDLP.....Q...DPVELARLGLRHMEP.DLSARV..TIYQ.MPSSKDS.TGAADPAEPHIVG........................
#=GC seq_cons                        ...........................................stt.................t.tpt.tcsl......s.hcchFpps...tp+sKsoFhpsl.....ph..........Ftp..+s.l.++RGHV-FIYsAL++McEaGV-+DLsVYptLLDVFP.K.t..hFh...P......cNhh.QphF.....h....HYP+QQpCulslLEQMEsa..G........VhPspEhchlLlplFGc+uaPhpKahRMhYWhP+FKslNPaPlP....csLP.....p...DPl-LApluLc+hss.Dlsucl..Tlap.hspsc-s..s.....psaIVu........................
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