#=GF ID ECSIT
#=GF AC PF06239.6
#=GF DE Evolutionarily conserved signalling intermediate in Toll pathway
#=GF AU Finn RD
#=GF SE Pfam-B_9306 (release 9.0)
#=GF GA 24.30 24.30;
#=GF TC 24.30 35.60;
#=GF NC 24.20 24.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 10465784
#=GF RT ECSIT is an evolutionarily conserved intermediate in the
#=GF RT Toll/IL-1 signal transduction pathway.
#=GF RA Kopp E, Medzhitov R, Carothers J, Xiao C, Douglas I, Janeway CA,
#=GF RA Ghosh S;
#=GF RL Genes Dev 1999;13:2059-2071.
#=GF DR INTERPRO; IPR010418;
#=GF CC Activation of NF-kappaB as a consequence of signaling through
#=GF CC the Toll and IL-1 receptors is a major element of innate immune
#=GF CC responses. ECSIT plays an important role in signalling to
#=GF CC NF-kappaB, functioning as the intermediate in the signaling
#=GF CC pathways between TRAF-6 and MEKK-1 [1].
#=GF SQ 101
#=GS G5AJT8_HETGA/8-236 AC G5AJT8.1
#=GS G3N6W3_GASAC/24-247 AC G3N6W3.1
#=GS B4JGQ9_DROGR/34-257 AC B4JGQ9.1
#=GS E9HFW4_DAPPU/28-242 AC E9HFW4.1
#=GS Q7QI51_ANOGA/22-243 AC Q7QI51.4
#=GS G1KZL1_AILME/38-268 AC G1KZL1.1
#=GS H9EXV8_MACMU/39-267 AC H9EXV8.1
#=GS I1FRG8_AMPQE/1-167 AC I1FRG8.1
#=GS B7PYZ8_IXOSC/41-254 AC B7PYZ8.1
#=GS F7BSY0_MACMU/39-267 AC F7BSY0.1
#=GS D3TPK5_GLOMM/35-260 AC D3TPK5.1
#=GS H3CG44_TETNG/50-278 AC H3CG44.1
#=GS B4NHG1_DROWI/22-245 AC B4NHG1.1
#=GS ECSIT_HUMAN/39-267 AC Q9BQ95.1
#=GS G6D235_DANPL/1-169 AC G6D235.1
#=GS F2TZC5_SALS5/121-297 AC F2TZC5.1
#=GS G3MHD4_9ACAR/103-319 AC G3MHD4.1
#=GS C8KHX2_PENJP/40-258 AC C8KHX2.1
#=GS H9FVE3_MACMU/39-267 AC H9FVE3.1
#=GS F1L829_ASCSU/8-86 AC F1L829.1
#=GS F6YXE5_HORSE/39-267 AC F6YXE5.1
#=GS ECSIT_XENLA/25-251 AC A2VD95.1
#=GS G1SLP7_RABIT/39-267 AC G1SLP7.1
#=GS B3NYI6_DROER/21-243 AC B3NYI6.1
#=GS B3LWB9_DROAN/18-241 AC B3LWB9.1
#=GS Q5C3X1_SCHJA/55-289 AC Q5C3X1.2
#=GS ECSIT_BOVIN/39-267 AC Q3SX05.1
#=GS G7YTU4_CLOSI/252-433 AC G7YTU4.1
#=GS D6WU07_TRICA/22-228 AC D6WU07.1
#=GS A9V8X9_MONBE/2-205 AC A9V8X9.1
#=GS ECSIT_DROME/20-243 AC Q9U6M0.2
#=GS E2RB12_CANFA/39-267 AC E2RB12.1
#=GS G7NL82_MACMU/39-267 AC G7NL82.1
#=GS Q297W7_DROPS/28-250 AC Q297W7.2
#=GS A8PQM3_BRUMA/17-130 AC A8PQM3.1
#=GS F7FTB5_MONDO/4-229 AC F7FTB5.1
#=GS E9ICX0_SOLIN/31-246 AC E9ICX0.1
#=GS C3Z7S7_BRAFL/28-253 AC C3Z7S7.1
#=GS A7RKS6_NEMVE/7-232 AC A7RKS6.1
#=GS E3WY35_ANODA/17-237 AC E3WY35.1
#=GS Q4T3A1_TETNG/50-278 AC Q4T3A1.1
#=GS F1LHM2_ASCSU/18-125 AC F1LHM2.1
#=GS B4G354_DROPE/28-250 AC B4G354.1
#=GS Q9N580_CAEEL/4-220 AC Q9N580.1
#=GS G3QRT8_GORGO/39-267 AC G3QRT8.1
#=GS F1SA28_PIG/7-235 AC F1SA28.1
#=GS H0W0W4_CAVPO/8-236 AC H0W0W4.1
#=GS B4QXL9_DROSI/20-243 AC B4QXL9.1
#=GS H2U7Y8_TAKRU/3-231 AC H2U7Y8.1
#=GS B4MC61_DROVI/246-472 AC B4MC61.1
#=GS E0VBY4_PEDHC/49-270 AC E0VBY4.1
#=GS G3VS11_SARHA/46-271 AC G3VS11.1
#=GS F6X0J0_CALJA/39-267 AC F6X0J0.1
#=GS F8W5R4_DANRE/51-139 AC F8W5R4.1
#=GS H9IF38_ATTCE/26-243 AC H9IF38.1
#=GS E4WXP1_OIKDI/2-217 AC E4WXP1.1
#=GS Q5DGF8_SCHJA/55-190 AC Q5DGF8.1
#=GS D2I6N0_AILME/8-238 AC D2I6N0.1
#=GS H2WIH1_CAEJA/12-221 AC H2WIH1.1
#=GS G3H694_CRIGR/39-266 AC G3H694.1
#=GS F7EV14_ORNAN/1-208 AC F7EV14.1
#=GS H9JC15_BOMMO/1-169 AC H9JC15.1
#=GS ECSIT_DANRE/52-280 AC Q08CK1.1
#=GS G7PZF5_MACFA/39-267 AC G7PZF5.1
#=GS ECSIT_MOUSE/39-267 AC Q9QZH6.2
#=GS H3IDE3_STRPU/46-261 AC H3IDE3.1
#=GS F4W6S6_ACREC/27-244 AC F4W6S6.1
#=GS H9KQE4_APIME/12-232 AC H9KQE4.1
#=GS E2BJP5_HARSA/31-254 AC E2BJP5.1
#=GS E1FZ24_LOALO/15-237 AC E1FZ24.1
#=GS ECSIT_MACFA/39-267 AC Q4R5Q4.1
#=GS G4VSP0_SCHMA/55-283 AC G4VSP0.1
#=GS I0FSC2_MACMU/39-267 AC I0FSC2.1
#=GS B6IDJ7_DROME/20-243 AC B6IDJ7.1
#=GS F7BSY7_MACMU/39-267 AC F7BSY7.1
#=GS E2RB15_CANFA/39-267 AC E2RB15.1
#=GS G3UEA5_LOXAF/8-238 AC G3UEA5.1
#=GS F6TG92_XENTR/23-261 AC F6TG92.1
#=GS B3RPX5_TRIAD/55-258 AC B3RPX5.1
#=GS G1RPX7_NOMLE/39-267 AC G1RPX7.1
#=GS E5SIB9_TRISP/40-166 AC E5SIB9.1
#=GS B4I491_DROSE/21-244 AC B4I491.1
#=GS H2XTD8_CIOIN/1-188 AC H2XTD8.1
#=GS F1QSV0_DANRE/52-280 AC F1QSV0.1
#=GS E3M651_CAERE/8-220 AC E3M651.1
#=GS H0WVJ4_OTOGA/39-267 AC H0WVJ4.1
#=GS ECSIT_XENTR/23-253 AC Q0V9C9.1
#=GS H3BCG7_LATCH/51-280 AC H3BCG7.1
#=GS Q17B53_AEDAE/23-248 AC Q17B53.1
#=GS E9C9V9_CAPO3/104-320 AC E9C9V9.1
#=GS H2M860_ORYLA/49-274 AC H2M860.1
#=GS ECSIT_RAT/38-266 AC Q5XIC2.1
#=GS B4K710_DROMO/10-232 AC B4K710.1
#=GS B4PVJ6_DROYA/20-243 AC B4PVJ6.1
#=GS F1L975_ASCSU/1-66 AC F1L975.1
#=GS G1PUE5_MYOLU/39-268 AC G1PUE5.1
#=GS B0W9N2_CULQU/19-242 AC B0W9N2.1
#=GS E2APA7_CAMFO/27-244 AC E2APA7.1
#=GS G1KTD3_ANOCA/1-211 AC G1KTD3.1
#=GS A8WQY1_CAEBR/4-221 AC A8WQY1.2
#=GS E4YSP2_OIKDI/2-209 AC E4YSP2.1
G5AJT8_HETGA/8-236 ....................................rSLHCSSAHRTSE..KS...VVPH....PP.EPGK..KPVKV...PVPYEDLFQLAPGGTRDKASFMKALQSFGQHN.VRKRGHVDFIYFALQKMPEYGVERDLAAYNLLLDVFP.K.EVFR........PRNFIHTLFF....HYLLQQDCGVAVLHQMESN...G........VMPNKETEFLLLQIFGRQSYPMLKYMRMHLWFTRFLN..INPFPVP.RDLPQ....DAV...ELATLGLQHMEP.DLSARVTVYQ.RP.LPDDKTDPGDPTKPHIVGI.......................
G3N6W3_GASAC/24-247 ......................rhfhsgparpkeqpi------------..--...PAEF....VN.GDDK..KRDRS...LVAHDDLFERVAREVKTKATFNKVVDVFIKND.VRRRGHVEFIYAALKKMPEFGVERDLVVYNRLLDVFP.K.EVFV........PRNFIQRMFN....HYPRQQECGVQLLEQMENY...G........IMPNMETKVLLVQIFGEKGHPMRKFQRIMYWFPKFKH..VNPFPVP.KHLPE....DPV...DLARFSLTRIAN.DRDAKVTVHQ.WG.LLKK---------------dtqdsrgvhg.............
B4JGQ9_DROGR/34-257 .............................ttddanrn------ANADPK..SN...NKSN....KR.AGTT..SSSKS...LPAIRNPFAAA--QDKTKNTYLTMVEIFEERD.VHRRNHVEFIYAALKHMPDFNVEHDLEVYKALINVMP.K.GKFI........PTNLFQAEFM....HYPKQQQCIIDLLEQMEDY...G........VMPDYEMEAMLLNVFGNKGHPLRKYWRMMYWMPKFKN..LSPWPLP.DPVPD....DTL...EIAKLAVERMCTvDLRSKIDVFE.TR.EIKDSLD-----DTWIVS-g......................
E9HFW4_DAPPU/28-242 .................clqsrhihinslhfknkepn------------..--...----....--.----..----E...LIVSPSMFYV-PEGDRNKDTFLEAVKIYTTRP.GPRRAQVEFIYAALKEMEEFGVHRDLEAYKDIIDILP.K.GKYI........PTNMFQAEFM....HYPKQQQCIIDVLEQMENN...G........VCPDKETDQMVLNIFGRHGAPTKKLRRMAYWMPKFKN..QSPWALP.QKIPN....SNL...EIAKLAVQRMGSvDPATEMNIFQ.TS.ELQDAID-----DTWIV--ng.....................
Q7QI51_ANOGA/22-243 ...................................st-TLRQCSTKRNE..ET...ADGK....PE.DGGG..KQGS-...LIVRTNLFESA--AKKDKQTYIEMVKIFEKRS.VHRRNHVEFIYAALRHMEEFGVNKDIAVYKALIDVMP.K.GKFI........PTNIFQAEFM....HYPRQQQCIIDLLEQMEDN...G........VMPDYEMEAMLVNVFGKKGHPVRKYWRMMYWMPKFKN..LSPWLLP.NPVPD....DAL...ELARLAVERMCSiDPRSKIQVFD.TQ.EVESAID-----HTWVVS-g......................
G1KZL1_AILME/38-268 ..................................rgl--HGSLAARNSD..SW...LVPP....PP.EPRKgpRPTKA...LALHEELFQQAPEGARDKANFVRAVQNFGQHN.VHKRGHVDFIYLALRKMREYGVERDLAVYNLLLDVFP.K.EVFR........PRSIFQSIFI....HYPRQQECGIAVLEQMESH...G........VMPNKETEFLLIQIFGRKSYPMLKFVRMKLWFSRFKN..INPFPVP.RDLPQ....DPV...DLAKLGLRHMEP.NLSATVTIYQ.MP.SSKDSTGAADPAEPHIVGI.......................
H9EXV8_MACMU/39-267 ....................................rGLHCSAAPHSSE..QS...LVSS....PP.EPRQ..RPTKA...LVPYEDLFGQAPSGERDKASFLQAVQKFGEHS.VRKRGHVDFIYLALRKMREYGVERDLAVYNQLLDIFP.K.EVFR........PRNVIQRIFV....HYPRQQECGIAVLEQMESH...G........VMPNKETEFLLIQIFGRKSYPMLKLLRLKLWFPRFMN..INPFPVP.RDLSQ....DPV...ELATFGLRHMEP.DLSARVTIYQ.VP.LPKDSTGAADPPQPHIVGS.......................
I1FRG8_AMPQE/1-167 ...................................ms------------..--...----....--.----..-----...---------------------------YMSLE.KNRSGHMKFIKEGLSRMDEFGLQKDLLSYNRLLDLFP.K.GRFN........NKSFFDTLWP....KPHPQIDLALEILSKMEDN...G........IRPDNVTYTILCETFSRISLPVQKCERIAFWFDKFED..IDPYRIK.GDMPT....DLY...TLSKMALQRISGeDC--------.--.-------------------kvwnikeaegegdtdsfviaa..
B7PYZ8_IXOSC/41-254 ........................rnlhvsrshyffr------------..--...----....--.KKQK..VSETR...LALREEIFKSE--QCRDREGFIEVIERFKLGN.ENRKGHVEFINVATKYLEEFNVHKDLAIYKMLFDLFP.K.GRYP........PKNQIQAEFQ....HFPYHQDCALRLLDVMEYN...A........VVPDRELRQAVLDTFGFHSEVFKKFARMMYWMPKLKN..LSPFPLP.TPLPR....EPL...ELAKLAVRRMCV.DLRTVVSVRE.TS.EVKDSVD-----QTWVVS-g......................
F7BSY0_MACMU/39-267 ....................................qGLHCSAAPHSSE..QS...LVSS....PP.EPRQ..RPTKA...LVPYEDLFGQAPSGERDKASFLQAVQKFGEHS.VRKRGHVDFIYLALRKMREYGVERDLAVYNQLLDIFP.K.EVFR........PRNVIQRIFV....HYPRQQECGIAVLEQMESH...G........VMPNKETEFLLIQIFGRKSYPMLKLLRLKLWFPRFMN..INPFPVP.RDLSQ....DPV...ELATFGLRHMEP.DLSARVTIYQ.VP.LPKDSTGAADPPQPHIVGS.......................
D3TPK5_GLOMM/35-260 ...........................eesegenses------DSFQQQ..RK...KQNS....EE.QQKT..TSTSF...VPAIRNPFAEA--SEKTKGVYMSMVEIFTERD.IRRRNHVEFIYAAMKHMAEFGVERDLEVYKALINVLP.K.GKFI........PRNIFQAEFM....HYPKQQQCIIDLLEQMEDL...G........VMPDYEMEAMLLNVFGRSGHPLRKYWRMMYWMPKFKN..RSPWPLP.NPVPD....SAL...TMAKLAIERMCTvDVRSRISVFE.TK.NVVDAID-----DTWIVS-g......................
H3CG44_TETNG/50-278 ....................................kHFHSSPACAKKT..SV...PAAE....LF.NEDK..TKNSS...ALAHVDLFDHVAGEFKTKAMFNKAIDVYVKSD.VRRRGHVEFIYAALKRMPEFGVERDLAVYNKLLDVFP.K.EVFV........PRNFIQRMFN....HYPRQQECGVQILEQMENY...G........IMPNVETKVLLVQIFGEKSHPMRKYQRILYWFPKFKH..LNPFPVP.QELPA....DPV...DLARFSLTRIAD.DLDAEVTVYQ.VT.STDVSESGEHVSLPHIV--ep.....................
B4NHG1_DROWI/22-245 .............stdeantnsssgagnsssrgaggt------------..--...----....--.--KN..ATTSR...LPAIRNPFAAA--QEKTKNTYLTMVEIFQERD.VHRRNHVEFIYAALKHMPDFGVEHDLEVYKALIDVMP.K.GKFI........PTNIFQAEFM....HYPKQQQCIIDLLEQMEDF...G........VMPDYEMEAMLLNVFGNKGHPLRKYWRMMYWMPKFKN..LSPWPLP.DPVPD....DTL...EIAKLAVERMCTvDLRSQLRVYE.TS.ELKDALD-----ETWIVS-g......................
ECSIT_HUMAN/39-267 ....................................rGLHCSAAAHSSE..QS...LVPS....PP.EPRQ..RPTKA...LVPFEDLFGQAPGGERDKASFLQTVQKFAEHS.VRKRGHIDFIYLALRKMREYGVERDLAVYNQLLNIFP.K.EVFR........PRNIIQRIFV....HYPRQQECGIAVLEQMENH...G........VMPNKETEFLLIQIFGRKSYPMLKLVRLKLWFPRFMN..VNPFPVP.RDLPQ....DPV...ELAMFGLRHMEP.DLSARVTIYQ.VP.LPKDSTGAADPPQPHIVGI.......................
G6D235_DANPL/1-169 .....................................------------..--...----....--.----..-----...--------------------------MFEDQD.TRRRGHVEFIYAALSRMNEFGVQKDLEVYKALVDVLP.K.GKFI........PVNIFQAEFL....HYPKQQQCAVDLLEQMENN...G........VMPDSELEQMLLNIFGRRGIPLRKYWRMMYWMPKFKN..LSPWPLP.ESLPD....NTL...ELANLAIQRITSvDPDTKIDVWQ.TE.EIEASID-----KTWIV--ca.....................
F2TZC5_SALS5/121-297 ..................aplppevearvrdvlggts------------..--...----....--.----..-----...----TRELAQVVQLAQDEEQLFSIVDVIVQN-.QPARGHVKFINAVLNRMDELNADVEVHFYNRLLEVFPvT.NTYK........TKSLLDAVWP....RPSLQVDAALKVLNRMENE...G........VMPNGHTFHSLMEVFGRASQPIKKVRSMGYWMRYFMD..SNPFSI-.-----....---...------------.----------.--.-------------------smlperprnerafmh........
G3MHD4_9ACAR/103-319 ..................clstssarlffgrrkgpls------------..--...----....--.----..SSETA...VALRESLFKSE--EQRNREGFIEVIERFKMGN.ANRKGHVEFINVATRFLTEFGVEKDLEVYKMLFDLFP.K.GKYT........PRSLVQAEFF....HFPYHQDCGVRLLDTMESH...G........VIPDRELRQMVLDTFGFYSEVFKKFARMMYWMPKFKH..MSPFPLP.NPVPR....DSF...ELARLAIKRMCV.DIQTAISVHQ.TKeEVPDAVD-----DTWIVS-a......................
C8KHX2_PENJP/40-258 hntlsaieryhillsdmfpgrnvrtklvfpckdtsar------------..--...----....--.----..-----...-------------MTNPKRHLLQHARSLKKKS.KHLRGHVEFIYAALRHVEEFGVQKDLETYKELLDLMP.K.GKMI........PQNIFQAEFM....HYPKQQQCAIDVLEQMETN...G........VMPDTEMEMILMNSFGKYSHPVRKYGRMMYWMPKFKN..ASPWSLP.DVVSN....DAF...DLAKMAVTRMCTvDSTSKITTYD.TK.DVEDAVD-----DTWIIS-g......................
H9FVE3_MACMU/39-267 ....................................rGLHCSAAPHSSE..QS...LVSS....PP.EPRQ..RPTKA...LVPYEDLFGQAPSGERDKASFLQAVQKFGEHS.VRKRGHVDFIYLALRKMREYGVERDLAVYNQLLDIFP.K.EVFR........PRNVIQRIFV....HYPRQQECGIAVLEQMESH...G........VMPNKETEFLLIQIFGRKSYPMLKLLRLKLWFPRFMN..INPFPVP.RDLSQ....DPV...ELATFGLRHMEP.DLSARVTIYQ.VP.LPKDSTGAADPPQPHIVGI.......................
F1L829_ASCSU/8-86 ............................sesgilrlk------------..--...----....--.----..-----...--------------------------------.-------------------------------------.-.----........----------....-------------------...-........-----------------------RLNVCCYWMPKLKH..SNKYLDR.RSIEGr.evGAV...ELAFIALKMMAR.DPGTAFSYVT.VK.DCEL---------------peserwmvsa.............
F6YXE5_HORSE/39-267 ....................................rGLHCSTAAHHSD..SS...LVPR....PP.EPPR..RPAKA...LALHEELFRQAPDGARDKASFVQAVQKFGQHN.VHRRGHVDFIYLALRKMREYGVERDLAVYNLLLDVFP.K.EVFR........PRSVLHSIFI....HYPRQQECGIAVLEQMENH...G........VMPNKETEFLLLQIFGRKSYPMLKFLRMKLWFSRFKN..INPFPVP.RDLPQ....DPV...ELARLGLRHMEP.DLSARVTIYQ.MP.SSKDSTGAADPAEPHIVGI.......................
ECSIT_XENLA/25-251 .........................tlghkaqrpmtc------------..-S...LHTS....QP.PGPP..QTTSSagsVAPYEDVFKK---EQRNKSNFVEVLDLYCKRD.TRRRGHVEIIETALRWMPEFGVEKDLEVYNKLLDVFP.K.EIFI........PQNFIQRMFN....HYPRQQECAIRVLEQMEHY...G........ITPNKQTCFLLLQIFGDRSHPIKKYQRMMYWFPRFKY..TNPFPVP.AELPA....DPV...ELSRMCLHRIAA.DLDSRVAVHQ.MP.YTEKCDDGKEQEHLHIVGI.......................
G1SLP7_RABIT/39-267 ...................................rg-LHRSAAACSSD..LS...LVPS....PP.ESQR..RPVKV...LEPHEELFKQAPGGERDKASFVRAVQCFGQQD.VRRRGHVDFIYLALRKMREFGVQRDLAVYNLLLDVFP.K.EVFR........PRNVFQRMFV....HYPRQQECGVAVLEQMEQH...G........VMPDTQTEFLLTQIFGRRSYPMLKLVRMKLWLTRFKN..VNPFPVP.LHLPP....DPV...DLAKLGLRHMEP.DLSARVTVYQ.MS.LPSDPASPEEPAQPHIVGI.......................
B3NYI6_DROER/21-243 ..................................shl---RCYSTDEGS..PK...QNPN....PN.PRAQ..KPGTK..nLPSVRNPFATA--QDRTKNSYLTMVEIFQERD.VHRRNHVEFIYAALKNMADFGVEKDLEVYKALINVMP.K.GKFI........PTNLFQAEFM....HYPKQQQCIIDLLEQMEDC...G........VMPDYEMEAMLLNVFGRQGHPLRKYWRMMYWMPKFKN..LSPWPLP.DPVPD....DTL...EMAKLAVERMCTvDLRSKITVFQ.TS.ELKDAID-----DTWIVS-g......................
B3LWB9_DROAN/18-241 ..................................alq--FRSYAKDGAN..SK...QNPN....PN.PRAQ..KQGSK..nLPAVRNPFATA--QDRTKDSYLTMVEIFNERD.VHRRNHVEFIYAALKNMADFGVERDLEVYKALINVMP.K.GKFI........PTNLFQAEFM....HYPKQQQCIIDLLEQMEDL...G........VMPDYEMEAMLLNVFGRQGHPLRKYWRMMYWMPKFKN..LSPWPLP.DPVPD....DTL...EIARLAVERMCTvDLRSKVTVFE.SK.DLKDAID-----DTWIVS-g......................
Q5C3X1_SCHJA/55-289 ....................................sNQSKESQSIPND..GE...WLNA....VR.DAER..SELLH...LKGSETDITRTELRKWKKRAFLHILEMFIQRSgPTRKGYFSFIQHALTKMLEYETFDDLECYKAIIRLFP.T.GRMT........VTRYFQSEFI....HYPRHQQLLIDLLNQMARY...H........VLPDDEVGQLIINVFGYRSHAMQHYRRLMYWMPKLYH..CNPWPLP.QRITDdldiDPI...KLGWLIAERICP.DRMTEFTVVQtLS.SISSSSSSVDRPDSLISA-q......................
ECSIT_BOVIN/39-267 ...................................rg-LRCSAAAHNPD..SS...LVPH....PP.EPPR..RPVKA...LAVHEELFRPALDGARNKANFVRAVQNFTEYN.VHKRGHVDFIYLALRKMREYGVERDLSVYNLLLDIFP.K.EVFR........PRNIFHSIFL....HYPRQQECGIAVLEQMENH...G........VMPNKETEFLLLQIFGRKSYPMLKLVRMKLWFTRFKN..INPFPVP.RDLPQ....DPV...DLASLALRHMEP.DLSARVTTYQ.MP.LLKDSPNAMDPTETHIVGI.......................
G7YTU4_CLOSI/252-433 ...................................ge------------..--...----....--.----..-----...----------------------HAINVYLERYgKTRRGFNQFALNALDKMPEYEVTDDLDCYKAILRVFP.P.GRMV........VTSFLQAEWN....HFPRQQDTVIKLLQQMSKH...H........VIPDDEVGQMIIDIFGWRCHAMTHYRHLMYWVPKLAH..ANPWPVA.QHILDdldeDPL...HLARLIAERICS.DPMAELRLVR.LS.D-SKCDN-SQQPSSMIS--aq.....................
D6WU07_TRICA/22-228 ......................plartfsdssepkql------------..--...----....--.----..-----...--VTYRSFEEI--ETKNKNTYLDMIHIFVNRDsVHRRGHVEFIYSALKNMESFGVHKDLEVYKALIDVLP.K.GKFI........PRNMFQVEFM....HYPKQQQCIIDLLEQMEDN...A........VMPDYDMEELLKNIFGNRGFPLRKYWRMMYWMPKFKN..ASPWPIP.NPLPD....GVY...ELAKCAIERISSvDIQTQVTTYQ.SK.DIEDCVD-----DTWIIS-a......................
A9V8X9_MONBE/2-205 ......................aqykaargpdedpap------------..--...--SS....SA.DPGP..ERHHQ...VAGLAEAAHRQLQQAQTVTELHQAIDAFRAAE.-PQHGHVAFLNATMERVAEIDEPLPLATYDNLLNIFP.KtNTFK........TSSLLDAIWP....RQTLQGEAALRVLNHMETD...G........LIPQASTHAILLRTFGAASAPVKKVTYMAYWMQRFFG..SNPFALP.LPLPQ....TDE...AWLHLALRRFAG.----------.--.-------------------kdatvhga...............
ECSIT_DROME/20-243 ...................................vs-RFRNYATDEGN..PK...QNPN....PN.PRAQ..KPGTK..nLPALRNPFAAA--QDRTKNSYLTMVEIFQERD.VHRRNHVEFIYAALKNMADFGVERDLEVYKALINVMP.K.GKFI........PTNMFQAEFM....HYPKQQQCIIDLLEQMEDC...G........VMPDHEMEAMLLNVFGRQGHPLRKYWRMMYWMPKFKN..LSPWPLP.DPVPD....DTL...EMAKLALERMCTvDLRSKITVFE.TS.ELKDAID-----DTWIVS-g......................
E2RB12_CANFA/39-267 ...................................rg-LHRSAIACNSD..SW...LVPP....SP.EPPK..GPPKA...LAPHEELFTQALGGTRDKANFVRAVQNFGQHN.VYKRGHVDFIYLALRKMREYGVERDLAVYNLLLDVFP.K.EVFR........PRSIFQTMFI....HYPRQQECGIAVLEQMESH...G........VMPNKETEFLLLQIFGRKSYPMLKFIRMKLWFSRFKN..INPFPVP.RDLPQ....DPV...DLAKLGLRHMEP.NLNATVTIYQ.MP.SSKDSTGAADPTEPHIVGS.......................
G7NL82_MACMU/39-267 ....................................rGLHCSAAPHSSE..QS...LVSS....PP.EPRQ..RPTKA...LVPYEDLFGQAPSGERDKASFLQAVQKFGEHS.VRKRGHIDFIYLALRKMREYGVERDLAVYNQLLDIFP.K.EVFR........PRNVIQRIFV....HYPRQQECGIAVLEQMESH...G........VMPNKETEFLLIQIFGRKSYPMLKLLRLKLWFPRFMN..INPFPVP.RDLSQ....DPV...ELATFGLRHMEP.DLSARVTIYQ.VP.LPKDSTGAADPPQPHIVGI.......................
Q297W7_DROPS/28-250 ...........................vlhrnysade---------TNS..NS...GNPN....AK.RAGT..GGSKS...LPAVRNVFAAA--QDKTKDTYLTMVEIFQERD.VHRRNHVEFIYAALKHMPDFGVENDLEVYKALINVMP.K.GKFI........PTNLFQAEFM....HYPKQQQCIIDLLEQMEDF...G........VMPDYEMEAMLLNVFGNKGHPLRKYWRMMYWMPKFKN..LSPWPLP.NPVPD....DTL...EIAKLAVERMCTvDLRSQINVFD.TK.ELKDAVD-----ETWIVS-g......................
A8PQM3_BRUMA/17-130 ........................cckpvcqayrfas------------..--...----....--.ENNE..TIRKK...LLPSEQRFDEVVIELRSKQTFLNVIDNFCKKQ.THARGHVEFINAALKYMKEYGLQKDLDIYKALLNIFP.K.GPMI........PTNVFQDE--....-------------------...-........-------------------------------------..-------.-----....---...------------.----------.--.-------------------dfenwesewd.............
F7FTB5_MONDO/4-229 ..................................rsf--HSSTARQTSD..SE...PLPM....VK.P-PG..MPTKT...LEPYEDFFEQASGGKRDKSGFSKAVKTFAQRD.IRKRGHVDFIYLALRKMPEYGVEHDLAIYNLLLDIFP.K.EVFV........PRNVLQQIFN....HYPRQQECGVKVLDQMENF...G........VLPNKETEFLLLQIFGRKSHPMRKYLRLMYWLPRFKN..INPFPLP.RPLPK....DPV...DLARHGLERIAA.DLSARITVYQ.MP.EPED--LGVDPPQPHIVGI.......................
E9ICX0_SOLIN/31-246 ............................lsriihiss------------..--...-QQR....TK.NKED..DKDSK...TSLVLHAFENV--GKKEKQAYLDIIREYKSKN.EKRHGHVEFIQVALKYMDEFGVNRDLAVYKSLVDVLP.K.GKFI........PRNFYQTMFM....HYPKQQYVTVDLLCKMEHN...C........VLPDLEMQEILLNIFGKHGLPLKKFWRMMYWMPKFAN..LNPWPCP.RPAPR....DPR...ELARLAMSKISSvDVQTSITDFD.TK.DVEDAIE-----NTWIVS-a......................
C3Z7S7_BRAFL/28-253 ............................gsyrqaall---------HSS..SQ...HLAK....KD.TQEN..NDSRA...LVLHKQIFEDVHPEIRTKANFLKVLDNFTKRD.IRRRGHVEFIYAALAKMKDFGVHKDLEVYNKIFDVFP.K.NVFV........PTNFIQSLYN....HYPRQQETGIAILEQMEYY...G........VMPSADTADLIISVFGFRSHPMKKFRRILYWFPKFKH..INPYPLP.DPLPA....DPV...DLARLALKRMAD.DRKAEFKVFQ.RE.DDET---------------essiktyvtsiqt..........
A7RKS6_NEMVE/7-232 ..........hsdirndtvielsekaiesritsakpa------------..--...----....--.----..-----...PSKFALRFETALSQGKTRDNFIEILESFSRHD.RNRRGHMELLKTAMNYMDIYGLEKDLLAYNAMLDVFP.R.GRFQ........NRTLFDAVWP....KKHPQVDLALEILTKMEEN...V........IKPSIETYDICEEIFGKASQPVQKVRRLAYWLTKLEE..MFPSPLP.AELPE....GEL...ELSMVAMERMSKeGL--PIVVFQdLS.EGNS---------------eefivssqtpeqqal........
E3WY35_ANODA/17-237 .......................ssrfgvasftrqcs------------..--...--TK....PEaEQGD..SEEKS...VILRTNLFETT--KNKDKHTYLEMVKIFESRS.VHRRNHVEFIYAALKHMEAFGVHKDLAVYKALIDVMP.K.GKFV........PTNLFQAEFM....HYPRQQQCIIDLLEQMEDN...G........VMPDYEMEAMLVNVFGRKGHPVRKYWRMMYWMPKFKN..LSPWLLP.NPVPN....DAL...ELARLAVERMCIvDPRSKIDVFD.TK.TVEDAID-----HTWIVS-g......................
Q4T3A1_TETNG/50-278 ....................................kHFHSSPACAKKT..SV...PAAE....LF.NEDK..TKNSS...ALAHVDLFDHVAGEFKTKAMFNKAIDVYVKSD.VRRRGHVEFIYAALKRMPEFGVERDLAVYNKLLDVFP.K.EVFV........PRNFIQRMFN....HYPRQQECGVQILEQMENY...G........IMPNVETKVLLVQIFGEKSHPMRKYQRILYWFPKFKH..LNPFPVP.QELPA....DPV...DLARFSLTRIAD.DLDAEVTVYQ.VT.STDVSESGEHVSLPHIVGI.......................
F1LHM2_ASCSU/18-125 ........................yaqsellwrhass------------..SS...SRGE....KR.SNNP..SET-R...LQHIDEHFESIPPEQRNKRTFNAAIDLFRLKK.TQTRGHVEFINSALKYLEEYGLHKDLDTYKAILNVFP.K.GAMI........PRNTF-----....-------------------...-........-------------------------------------..-------.-----....---...------------.----------.--.-------------------.......................
B4G354_DROPE/28-250 ...........................vlhrnysade---------TNS..NS...GNPN....AK.RAGT..GGSKS...LPAVRNVFAAA--QDKTKDTYLTMVEIFQERD.VHRRNHVEFIYAALKHMPDFGVENDLEVYKALINVMP.K.GKFI........PTNLFQAEFM....HYPKQQQCIIDLLEQMEDF...G........VMPDYEMEAMLLNVFGNKGHPLRKYWRMMYWMPKFKN..LSPWPLP.NPVPD....DTL...EIAKLAVERMCTvDLRSQINVFD.TK.ELKDAVD-----ETWIVS-g......................
Q9N580_CAEEL/4-220 ....................ahvsrrvisnqircfaa------------..--...----....--.---A..NQETS...LVHVEKQFEAIEPEKRDKDAFMAAIATFKEK-.-RGRTHVEFINTALKYVKEYGVHKDIDTYKGLLEVFP.K.GKMI........PQTVFQKVFL....HYPQQQNCAVKVLDEMEWH...G........VQPDKEIHDIVVNAFGEWNFATKKVKRMLYWMPKLKH..SNKYLDR.RHVEG....KSLspsELAGIALKMMSR.DAASSISLLK.LS.------DSSDPQQKWLAT-s......................
G3QRT8_GORGO/39-267 ....................................rGLHCSAAAHNSE..QS...LVPS....PP.EPRQ..RPTKA...LVPFEDLFGQAPSGERDKASFLQTVQKFAEHS.VRKRGHVDFIYLALRKMREYGVERDLAVYNQLLNIFP.K.EVFR........PRNIIQRIFV....HYPRQQECGIAVLEQMENH...G........VIPNKETEFLLIQIFGRKSYPMLKLVRLKLWFPRFMN..INPFPVP.RDLPQ....DPV...ELAMFGLRHMEP.DLSARVTIYQ.VP.LPKDSTGAADPPQPHIVGI.......................
F1SA28_PIG/7-235 ...................................hg-LHCSTAMHTFD..SS...LVPH....PP.KPPR..RPIKA...LALHEELFRKAPDGTREKASFVQAIQDFAQYN.VHKRGHVDFIYLALRKMREYGVERDLAVYNLLLDIFP.K.EVFR........PRSIFQTIFY....HYPRQQECGIAVLEQMENH...G........VMPNKETEFLLIQIFGRKSYPMLKYVRMKLWFTRFRN..INPFPLP.RDLPQ....DPV...DLARLALRHMEP.DLSARVTVYQ.MS.LPEDSKDAVDPTEPHIVGI.......................
H0W0W4_CAVPO/8-236 ...................................rg-LHCSSSPLSSV..KA...PVPR....PP.EPGK..KPGEV...RAPHEELFQPAPGGARDKASFALAVQNFGRHS.VRKRGHVDFIYLALRKMPEFGVERDLAAYNLLLDVFP.K.EVFR........PRSAFQRIFT....HYPRQQECGVAVLEQMERH...G........VMPNKETEFLLLQIFGRGSHPMLKYVRMRLWLTRFQN..INPFPLP.HELPQ....DVV...ELATLGLRRVEP.DLSARVTVYQ.KS.LPADTTDPVDPIQPHIVGI.......................
B4QXL9_DROSI/20-243 ...................................vs-RLRCYATDEGN..PK...QNPN....PN.PRAQ..KPGTK..nLPALRNPFTAA--QDRTKNSYLTMVEIFQERD.VHRRNHVEFIYAALKNMADFGVERDLEVYKALINVMP.K.GKFI........PTNMFQAEFM....HYPKQQQCIIDLLEQMEDC...G........VMPDHEMEAMLLNVFGRQGHPLRKYWRMMYWMPKFKN..LSPWPLP.DPVPD....DTL...EMAKLALERMCTvDLRSKITVFE.TS.ELKDAID-----DTWIVS-g......................
H2U7Y8_TAKRU/3-231 .................................khfh---GSLVCAKRN..SV...PSAQ....PL.NEDK..KSNDS...ALIHADLFDHVSGTFKTKATFNKAIDVFIKSD.VRRRGHVEFIYAALKKMPEFGVERDLAVYNKLLDVFP.K.GVFV........PRNFIQRMFN....HYPRQQECGVQILEQMENY...G........IMPNLETKVLLVQIFGEKGHPVRKYQRIMYWFPKFKE..LNPWPIP.KDLPT....DPV...DLARFSLARIAD.DLDAQVTVYQ.VP.HTDVTEKGEHVTLPHIVGI.......................
B4MC61_DROVI/246-472 ..............................fsksrny------ATDEAN..EN...ANTDdaksSK.KNNA..GTSRS...LPAIRNPFTAA--QEKTKNSYLTMVEIFAERD.VHRRNHVEFIYAALKHMPDFGVEHDLEVYKALIDVMP.K.GKFI........PTNLFQAEFM....HYPKQQQCIIDLLEQMEDY...G........VMPDYEMEAMLLNVFGNKGHPLRKYWRMMYWMPKFKN..LSPWPLP.DPVPD....DTL...EIAKLAVERMCTvDLRSKVEVFQ.AS.EVKDSLD-----DTWIVS-g......................
E0VBY4_PEDHC/49-270 .......ntkilsktfkhfksiqitsqlkycdekknk------------..--...----....--.----..-----...-IITFSDFEKW--SVKNKESFLETIRIYEATF.PNRKGHVEFVESALKQMETYGVHKDIEAYKRIIDILP.K.GVFV........VKNKWQATFY....NYPRQQFAAIEMLSKMEHY...G........VLPDAELGSILISIFGKFSQPCLKYFEQLYWCMKFRN..KSPWYLP.KQVPS....DAF...LLAQMAMERITSvDVKTEISVYQ.TD.DLLESID-----KTWIIS-g......................
G3VS11_SARHA/46-271 ..................rgfhnsarrltsdsdpvpm------------..--...----....VR.PPA-..VSTKA...LEPYEDFFEQATGGQRDKTGFSRAVKAFAQRD.VRKRGHVDFIYLALRKMPEYGVERDLAIYNILLDIFP.K.EVFV........PQNVLQQIFN....HYPRQQECGVKVLDQMENY...G........VMPNKETEFLLLQIFGRKSHPMLKYLRLTYWFLRFKN..INPFPVP.KPLPK....DPV...DLARHSLERIAA.DLSAKVTVYQ.MP.GPED--LGADPSQPHIVGI.......................
F6X0J0_CALJA/39-267 ....................................rGLHCSAATHSSE..TA...LVPT....PT.EPQQ..RRTKA...VVPYENMFGQAPNGKRDKASFLQAVQKFGEHS.VRKRGHVDFIYLALRKMREYGVERDLAVYNQLLDIFP.K.EVFR........PRNFIQHIFI....HYPRQQQCGVAVLEQMENH...G........VMPNKETEFLLIQIFGRKSHPMLKFLRLKRWFPRFMN..INPFPVP.RDLSQ....DPV...DLATFALRRIEP.DLSARVTVYQ.VA.SSKDSTDVADPTQPHIIGI.......................
F8W5R4_DANRE/51-139 .............................fhrsavcs------TDRQNR..TD...IEKL....VE.DETH..HKDKT...LVTHDDIFDRAAGDSKTKVEFNRVVDVFKSKD.IRRRGHVEFIYAALKKMPEFGVECDV-----------.-.----........----------....-------------------...-........-------------------------------------..-------.-----....---...------------.----------.--.-------------------.......................
H9IF38_ATTCE/26-243 ................egrslsraihtsqerckkdek------------..--...----....--.----..-DSKP...SGLVLHVFANA--ESRERKAYLDILREYKTNN.EMRRGHVEFIQVALKYMDEFGVNRDLAVYKAVLDVLP.K.GKFV........PRNYFQTIFM....HYPKQQHVAIDLLCKMEHN...C........VIPDLEMQEMLLNIFGMQALVLKKFWRMMYWMPKFAN..LNPWPCP.TPVPK....DPK...VLAKLAMNKISSiDVQTEITEFK.TK.DVEDAID-----DTWIVS-v......................
E4WXP1_OIKDI/2-217 .........................dksyanemeayl------------..--...----....--.----..-----...-----ADAEHSYIQEADKRAFYMAVELWKKEAgPGRQGHKDFVVMAIPTISQLGLSKDTKAYMTLLECWP.D.ANYVfaekspiyKQTTSQSTFFiekfEWTSDANLCKHLLRTMERN...G........CLCTNEIYAKVTDLFGIYSDASVLARQQMLFNKRLME..RNPFPID.--APK....DPT...ELAAATLRQASP.GFDRQYH---.--.-------------------rfpmkqrdgnwvrseksgeffes
Q5DGF8_SCHJA/55-190 ....................................sNQSKESQSIPND..GE...WLNA....VR.DAER..SELLH...LKGSETDITRTELRKWKKRAFLHILEMFIQRSgPTRKGYFSFIQHALTKMLEYETFDDLECYKAIIRLFP.T.GRMT........VTRYFQSEFI....HYPRHQQLLIDLLNQMARY...-........-------------------------------------..-------.-----....---...------------.----------.--.-------------------rk.....................
D2I6N0_AILME/8-238 ..................................rgl--HGSLAARNSD..SW...LVPP....PP.EPRKgpRPTKA...LALHEELFQQAPEGARDKANFVRAVQNFGQHN.VHKRGHVDFIYLALRKMREYGVERDLAVYNLLLDVFP.K.EVFR........PRSIFQSIFI....HYPRQQECGIAVLEQMESH...G........VMPNKETEFLLIQIFGRKSYPMLKFVRMKLWFSRFKN..INPFPVP.RDLPQ....DPV...DLAKLGLRHMEP.NLSATVTIYQ.MP.SSKDSTGAADPAEPHIVGI.......................
H2WIH1_CAEJA/12-221 ............................fyqircfas------------..--...----....--.--AS..HEQTS...LVHVEKQFEAVIPEKRDKDAFMAAIAMFKEK-.-RGRTHVEFINTALKYVKEYGVHKDLDTYKNLLDVFP.K.GKMI........PQTAFQKIFL....HYPQQQNCAVKVLDEMEWH...G........VQPDKEIHDIMVNAFGEWNFATKKVKRMLYWMPKLKH..SNKYLDR.RHVEG....KSLspsELAGIALKMMSR.DPASSISLLK.FS.------DSSDPVSKWLA--ts.....................
G3H694_CRIGR/39-266 ...................................rg-LHCSAVIHKDD..VS...LVPR....PP.EPQR..KPIKV...PVLHEELFTPSATGEKDKASFLRALRSFEEHS.VRKRGHVDFIYLALRKMPEFGVERDLSVYNLLLDVFP.K.EIFR........PRNIIQRIFV....HYPRQQECGISVLEQMERY...G........VMPNTETEFLLTQIFGRTSYPMLKFLRMKLWLTRFKN..INPYPVP.RDLPQ....DPL...DLAKLSLRRMEP.DLSAKVTVYQ.MS.LPSDSTG-TDPIQPHIVGI.......................
F7EV14_ORNAN/1-208 ...................................ra------------..--...----....--.----..-----...LVPFEDFFQRASGGSKDKAGFTRAVDVFNQRS.VRKRGHVDFIYTALRKMKEYGVERDLAVYNLLLDVFP.K.EVFV........PRNFIQRIFN....HYPRQQECGVQVLEQMENHarsG........VLPNKETEFLLLQVFGKKSYPMLKYHRIMYWFPRFKN..INPFPLP.KPLPQ....DPI...DLARLGLQRIAA.DLSARVTVYQ.VT.LQ-----------------mpaaaegpagasalfqphiig..
H9JC15_BOMMO/1-169 .....................................------------..--...----....--.----..-----...--------------------------MFENQD.NRRRGHVEFIYAALARMKEFGVHKDLQAYKALVDVLP.K.GKFI........PSNIFQAEFM....HYPKQQQCAVDLLEQMEDN...K........VMPDSELEQMLLNVFGKRGIPLRKFWRMLYWMPKFKN..LSPWYLP.DELPN....DTL...ELAKMAIHRITSvDPTMKIEIWQ.TE.EIEACID-----KTWIVS-a......................
ECSIT_DANRE/52-280 ..............................hrsavcs------TDRQNR..TD...IEKL....VE.DETH..HKDKT...LVTHDDIFDRAAGDSKTKVEFNRVVDVFKSKD.IRRRGHVEFIYAALKKMPEFGVECDVTVYNKLLDVFP.K.EVFV........PQNFIQRMFN....HYPRQQECGVQVLEQMENY...G........VMPNIETKVLLVQIFGEKSHPIRKFQRIMYWFPKFKH..TNPYPVP.HVLPS....DPV...DLAQFSLTRIAA.DLDAKITIYQ.YP.STDITETGEEITRPHIVGI.......................
G7PZF5_MACFA/39-267 ....................................rGLHCSAAPHSSE..QS...LVSS....PP.EPRQ..RPTKA...LVPYEDLFGQAPSGERDKASFLQAVQKFGEHS.VRKRGHIDFIYLALRKMREYGVERDLAVYNKLLDIFP.K.EVFR........PRNVIQRIFV....HYPRQQECGIAVLEQMESH...G........VMPNKETEFLLIQIFGRKSYPMLKLLRLKMWFPRFMN..INPFPVP.RDLSQ....DPV...ELATFGLRHMEP.DLSARVTIYQ.VP.LPKDSTGAADPPQPHIVGI.......................
ECSIT_MOUSE/39-267 ....................................rGLHCSAATHKDE..PW...LVPR....PP.EPQR..KPIKV...PAMHEDLFKPSGNRERDKASFLNAVRSFGAHN.VRKRGHVDFIYLALRKMPEFGVERDLSVYNLLLDVFP.K.EVFR........PRNVIQRIFV....HYPRQQECGVAVLEQMERH...G........VMPSAETEFLLIQIFGRKSYPMLKFLRMKLWFTRFKN..INPYPVP.RDLPQ....DPL...DLAKLGLRHMEP.DLSAKVTVYQ.MS.LPSDSTGMEDPTQPHIVGI.......................
H3IDE3_STRPU/46-261 ....................arclrdsdipagsgisr------------..--...----....--.----..VERNS...MVLSKTLFEEATHDSPNKGAFKEVVTTFTEMD.KRRRGHVQFIETALRYMKAFGVEKDVEAYNMLLDVFP.K.GKYV........AKNAYQSMFN....HFPEQQVCGIKVLQQMEDN...A........VLPNNNTKEILLAIFGRNAHPIKKYQRLMYWFPKFRN..INPFPLP.KEMPS....DPI...KLSEIGLKRISE.Y-EAEFTVYS.VD.RSSETSVM-----------vqdqdys................
F4W6S6_ACREC/27-244 .........................grslsrvihtsq------------..--...--ER....YK.KDDK..KDSKS...SALVLHAFANA--DSKEREAYLDILREYKTNN.EMRRGHVEFIQVALKYMDEFGVNRDLAVYKAVLDVLP.K.GKFV........PRNYFQTIFT....HYPKQQHVAIDLLCKMEHN...S........VIPDLEMQEMLLNIFGMQALVLKKFWRMMYWMPKFAN..LNPWPCP.KPVPK....DPK...VLAKLAMNKISSaDVQTEVTEFK.TK.DVEDAID-----DTWIIS-v......................
H9KQE4_APIME/12-232 iikkhknirltivnnlhikqvlcnknesaseitpynf------------..--...----....--.----..-----...-----------NVKKKEKETFLEIIHVYKKED.RIRKGQLQFILTALKYMDEFGVNKDLEIYKQLLDIFP.K.NKYI........PKNKFQNMFF....SYAKHQNVAISILKKMEKN...F........VIPDFEMQELIIQIFGDKNLVIKKCWNIFYWFPKFSQ..LNPWPIP.RPIPT....DPK...ELAKFAIAKMSCiDVQANTIVYK.TK.DIPDAID-----DTWIVSS.......................
E2BJP5_HARSA/31-254 ......................sartvnaihtsecrr------------..-N...DNDK....DK.DKKK..KKSKS...SALILHSFESV--EHKEKEAFLDVLREYKKEN.EIRRGHVEFIQVALKYMDEFGVNRDLAVYKALLDVLP.K.GKFV........PINYLQTLFM....HYPKQQYVGIDLLCKMEDN...S........VIPDVEMQQMLLNIYGVQSIVLKKFWRMMYWMPKFSN..LNPWPCS.RPAPK....DPR...VLARIAVNKLSSiDVTSIVTEYR.TK.DVEDSTE-----DTWILS-s......................
E1FZ24_LOALO/15-237 ......................slyckpvqslayrfa------------..--...----....-S.ESNE..KFGKE...LLPSEKRFDEVAIELRTKQTFLNVIDNFCKKQ.MHARGHVEFINSALKYMKEYGLQKDLDIYKSLLNIFP.K.GPMI........PTNVFQRRFL....YFPQQQICCVKLLDEMEWF...G........VQPDKEIHDLVVNAFGEWNYATKKVKRMLYWMPKLKH..SNTYLDR.RKIEG....KKLsavDLGYLALKMISR.DPGTRITLVG.IN.DTELSES------------drwllsaq...............
ECSIT_MACFA/39-267 ....................................rGLHCSAAPHSSE..QS...LVSS....PP.EPRQ..RPTKA...LVPYEDLFGQAPSGERDKASFLQAVQKFGEHS.VRKRGHIDFIYLALRKMREYGVERDLAVYNQLLDIFP.K.EVFR........PRNVIQRIFV....HYPRQQECGIAVLEQMESH...G........VMPNKETEFLLIQIFGRKSYPMLKLLRLKMWFPRFMN..INPFPVP.RDLSQ....DPV...ELATFGLRHMEP.DLSARVTIYQ.VP.LPKDSTGAADPPQPHIVGI.......................
G4VSP0_SCHMA/55-283 ....................................sSQSKDSRSVPND..SE...WIDA....VQ.NVEK..SELLH...LKGSDTNMTRTEIRKWKKRTFLHILEMFIQRSgPSRKGFTSFIQNALIKMPEYEVTDDLDCYKAVIRLFP.T.GRMT........VKRFLQADFG....HFPKQQQVMIDILNQMSRY...H........VLPDDEVGQMIIDVFGWRNHAMQTYRRLMYWMPKLYY..SNPWTLP.LRIADdldlDPI...KLGCLIAERICP.DRMTEFTVVQ.MP.SSNS-----DRLDSLI---saq....................
I0FSC2_MACMU/39-267 ....................................qGLHCSAAPHSSE..QS...LVSS....PP.EPWQ..RPTKA...LVPYEDLFGQAPSGERDKASFLQAVQKFGEHS.VRKRGHIDFIYLALRKMREYGVERDLAVYNQLLDIFP.K.EVFR........PRNVIQRIFV....HYPRQQECGIAVLEQMESH...G........VMPNKETEFLLIQIFGRKSYPMLKLLRLKLWFPRFMN..INPFPVP.RDLSQ....DPV...ELATFGLRHMEP.DLSARVTIYQ.VP.LPKDSTGAADPPQPHIVGI.......................
B6IDJ7_DROME/20-243 ...................................vs-RFRNYATDEGN..PK...QNPN....PN.PRAQ..KPGTK..nLPALRNPFAAA--QDRTKNSYLTMVEIFQERD.VHRRNHVEFIYAALKNMADFGVERDLEVYKALINVMP.K.GKFI........PTNMFQAEFM....HYPKQQQCIIDLLEQMEDC...G........VMPDHEMEAMLLNVFGRQGHPLRKYWRMMYWMPKFKN..LSPWPLP.DPVPD....DTL...EMAKLALERMCTvDLRSKITVFE.TS.ELKDAID-----DTWIVS-g......................
F7BSY7_MACMU/39-267 ....................................qGLHCSAAPHSSE..QS...LVSS....PP.EPRQ..RPTKA...LVPYEDLFGQAPSGERDKASFLQAVQKFGEHS.VRKRGHVDFIYLALRKMREYGVERDLAVYNQLLDIFP.K.EVFR........PRNVIQRIFV....HYPRQQECGIAVLEQMESH...G........VMPNKETEFLLIQIFGRKSYPMLKLLRLKLWFPRFMN..INPFPVP.RDLSQ....DPV...ELATFGLRHMEP.DLSARVTIYQ.VP.LPKDSTGAADPPQPHIVGI.......................
E2RB15_CANFA/39-267 ...................................rg-LHRSAIACNSD..SW...LVPP....SP.EPPK..GPPKA...LAPHEELFTQALGGTRDKANFVRAVQNFGQHN.VYKRGHVDFIYLALRKMREYGVERDLAVYNLLLDVFP.K.EVFR........PRSIFQTMFI....HYPRQQECGIAVLEQMESH...G........VMPNKETEFLLLQIFGRKSYPMLKFIRMKLWFSRFKN..INPFPVP.RDLPQ....DPV...DLAKLGLRHMEP.NLNATVTIYQ.MP.SSKDSTGAADPTEPHIVGI.......................
G3UEA5_LOXAF/8-238 ...................................rg-LHCSAATHSSDsdSS...VVPR....PP.EPSR..WPMKG...LAPHQELFGQAPSGERDKASFVQAVQNFKQHS.VRRRGHVDFIYLALRQMRQYGVERDLAVYNLLLDIFP.K.EVFR........PRSIIQYIFV....HYPRQQECGLAILEQMENH...G........VMPNKETEFLLIQIFGHKSYPMLKFLRMKLWFSRFKN..INPFPVP.QDLPQ....DPV...DLAKLGLRHMEP.DLSARVTIYQ.MP.LSKDSTGAADPTQPHIVGI.......................
F6TG92_XENTR/23-261 ........................gqalgtgnnaqkq------------..-VtccLHTS....PP.PGPP..QATSSagsVTPYEDVFQR---EQRNKASFVEVLDLYCNRD.VRRRGHVEIIEAALRWMTEFGVEKDLEVYNKLLDVFP.K.EVFV........PQNYIQRMFN....HYPRQQECAIRVLEQMENY...GkepttyysITPNKQTCFLLLQIFGARSHPIRKYQRMMYWFPRFKH..TNPFPVP.AELPA....DPV...ELSRMCLHRIAN.DLDSRVAVYQ.MP.YTEKCDDGKEREHLHVVGI.......................
B3RPX5_TRIAD/55-258 ..........................apiivkrfksn------------..--...----....--.----..DKIKN...LITVGAILEEA-LQTKQKDSFHQAIDKFNARD.RQRRGHVDFIYSALSLIDKFELEQDIETYNKLLDVFP.K.DRFV........NRSWLDVVWP....KPHPQIDCALDVLTKMEEE...G........ILPNEDTYRILYDVFGRKSFPLQKAQRIEYWFTRFKD..INPYKLP.SPVPT....DPI...ELGSIALQRIAGsD--GVITIYE.HD.K------------------kngedkfll..............
G1RPX7_NOMLE/39-267 ....................................rGLHCSAAAYSSE..QS...LVPS....PP.EPRQ..RPTKA...LVPFEDLFGQAPSGERDKASFLQAVQKFGEHS.VRKRGHVDFIYLALRKMREYGVERDLAVYNQLLNIFP.K.EVFR........PRSIIQRIFV....HYPRQQECGIAVLEQMENH...G........VMPNKETEFLLIEIFGRKSYPMLKLVRLKLWFPRFMN..INPFPVP.RDLPQ....DPV...ELAMFGLRHMEP.DLSARVTIYQ.VP.LPKDSTGAADPPQPHIVGI.......................
E5SIB9_TRISP/40-166 ......................dspkfhaiaflrkve------------..--...----....--.----..-----...--------------------------------.-------------------------------------.-.----........--------GM....HYPKQQQCCIDVLDEMEWW...R........VYPDKEIYLIVKNAFGEWTHAMRKMKRQMYWMPKFKN..ADPYPLP.RPVPN....SDI...EIAQAAMRRICR.DPANNVEVFY.TS.TVSDSTI-----NTWIVS-g......................
B4I491_DROSE/21-244 ...................................vs-RLRCYATDEGN..PK...QNPN....PN.PRAQ..KPGTK..nLPALRNPFTAA--QDRTKNSYLTMVEIFQERD.VHRRNHVEFIYAALKNMADFGVERDLEVYKALINVMP.K.GKFI........PTNMFQAEFM....HYPKQQQCIIDLLEQMEDC...G........VMPDHEMEAMLLNVFGRQGHPLRKYWRMMYWMPKFKN..LSPWPLP.DPVPD....DTL...EMAKLALERMCTvDLRSKITVFE.TS.ELKDAID-----DTWIVS-g......................
H2XTD8_CIOIN/1-188 .....................................------------..--...----....--.----..-----...-----------------KRTFYKLVDIWISEAgLARRGHREFIQAAMHAMPKFNVESDIRAYVRLLDCFP.D.GKHTg.....ihRSHWFYSAFQ....DKIADHSIAENLVSQISQH...G........AIPNDKLFNKALEIFGKFSPAMLAVRQCLFWYPRIIA..FQKHPISvSDFKE...lSPT...EIAFHGLRQMSP.GLDAKFRNFEvLQ.SE-----------------cdeilntdqldsvvsi.......
F1QSV0_DANRE/52-280 ..............................hrsavcs------TDRQNR..TD...IEKL....VE.DETH..HKDKT...LVTHDDIFDRAAGDSKTKVEFNRVVDVFKSKD.IRRRGHVEFIYAALKKMPEFGVECDVTVYNKLLDVFP.K.EVFV........PQNFIQRMFN....HYPRQQECGVQVLEQMENY...G........VMPNIETKVLLVQIFGEKSHPIRKFQRIMYWFPKFKH..TNPYPVP.HVLPS....DPV...DLAQFSLTRIAA.DLDAKITIYQ.YP.STDITETGEEITRPHIVGI.......................
E3M651_CAERE/8-220 ...................khfnlissrslstvnqdf------------..--...----....--.----..----G...LVHVEKQFEAIEPKKRDKDAFMAAIGTFKEK-.-RGRTHVEFINTALKYVKDYGVHKDLETYKSLLDVFP.K.GKMI........PQTVFQKVFL....HYPQQQNCAVKVLDEMEWH...G........VQPDKEIHDIVVNAFGEWNFATKKVKRMLYWMPKLKH..SNKYLDR.RSVEG....LSLtpsELAGIALKMMNR.DPATSISLLK.FS.------DSSDPKDKWMA--ta.....................
H0WVJ4_OTOGA/39-267 ....................................rGLHRSAAAHNSE..LS...LVPG....PP.EPQR..RPIRA...LAPHEDLFRQAPGGERDKASFVRAVQSFGQRN.VRKRGHVDFIYLALRKMREYGVERDVAVYNLLLDVFP.K.EVFR........PRNVIQRIFV....HYPRQQECGIAVLEQMENN...G........VMPNKETEFLLIQIFGRKSYPMLKYLRMKLWFPRFKN..INPFPIP.RDLPQ....DPV...DLAQLGLRHMEP.DLGAKVTIYQ.MP.VSNDWTGASDPTEPHIVGI.......................
ECSIT_XENTR/23-253 .........................gqalgtgnnaqk------------..QVtccLHTS....PP.PGPP..QATSSagsVTPYEDVFQR---EQRNKASFVEVLDLYCNRD.VRRRGHVEIIEAALRWMTEFGVEKDLEVYNKLLDVFP.K.EVFV........PQNYIQRMFN....HYPRQQECAIRVLEQMENY...G........ITPNKQTCFLLLQIFGARSHPIRKYQRMMYWFPRFKH..TNPFPVP.AELPA....DPV...ELSRMCLHRIAN.DLDSRVAVYQ.MP.YTEKCDDGKEREHLHVVGI.......................
H3BCG7_LATCH/51-280 .................................rsfy---TSPQAASSE..PA...PSAE....SK.DQER..GPRDK..sLVTYDDLFKKAAGDSRTKATFNRVVDTFCNKN.VRRRGHVEFIYAALKKMPEFGVERDINIYNRILDVFP.K.EVFV........PQNFIQRMFN....HYPRQQECGVQVLEQMENY...G........IMPNKETKFLLVQIFGEKSHPVRKYQRIMYWFPKFKH..ANPYPVP.AVLPQ....DPL...DLAKFSLQRIAA.DLDAKTTVFQ.MP.ATDISEDGAEVKQPYVVGI.......................
Q17B53_AEDAE/23-248 ...................................ct-KDTKGGPHHRP..EE...AEGD....TE.NDHH..QRKSSetrVALRTPLFEHV--STKDKKTYIEMVRVFEGRS.VHRRNHVEFIYAALKHMEEFGVHKDLEVYKSLINVMP.K.GKFI........PTNIFQAEFM....HYPRQQQVIIDLLEQMEDN...G........VIPDYEMESMLVNVFGKKGHPVRKYWRMMYWMPKFKN..LSPWPLP.NPVPD....DSL...DLAKMAVERMCSvDLLSQITLFD.TE.NVPDAID-----HTWIVS-g......................
E9C9V9_CAPO3/104-320 ..ehgalasaslsssssspsssssapaisaghlmrhm------------..--...----....--.----..-----...------------GAASNLAQIEAVVDAFREL-.KSVRGSVEFIEAAITRLDALDLDIPKRTYDKLLDVFP.K.NHTV........TRSWLDVMWP....RENAAVETALKLLQRMEDA...S........ICPDLETFKPVFYAFGKKSVPVRKCESMYYWMTLFGMnpKSKSYQI.KALPE....DLT...LVTQLALNRLVG.VSDAQI----.--.-------------------hqhgvfqrdgngavdvghv....
H2M860_ORYLA/49-274 ...................fhcspvfakdprlpgrlv------------..--...----....-G.EDDN..KRQTS...LVAHDDLFEQIAMGAKSKATFAKVIDVFK-RD.IRRRGHVEFIYAALRKMPEFGVERDLGVYNRLLDVFP.K.EVFV........PTNFIQRMFN....HYPRQQECGVQLLEQMENY...G........ITPNVETKVLLVQIFGEKSHPMRKYQRLMYWFPKFKH..LNPFPIP.QQLPE....DPV...DLARFSLTRIAN.DLDAKVTVHQ.LP.CSDVTESGEEIHRPYILG-i......................
ECSIT_RAT/38-266 ....................................rGLHCSAVTHKDD..VW...LVPR....PS.EPQK..KPIKV...PAMHEDLFRPSGNGEQDKASFLNAVRSFGEHN.VRKRGHVDFIYLALRKMPEFGVERDLSVYNLLLDVFP.K.EVFR........PRNAIQRIFV....HYPRQQECGVAVLEQMERH...G........VMPNTETEFLLIQVFGHKSYPMLKFLRMKLWFTRFKN..INPYPVP.RDLPQ....DPL...DLAKLGLRHMEP.DLSAKVTVYQ.MS.LPSESTGIEDPTQPHIVGI.......................
B4K710_DROMO/10-232 ..............................lnyatde------ANANHK..ND...SSNT....KR.GGAA..GSSKN...LPSIRNPFAAA--HEKTKNSYLTMVEIFEERD.VHRRNHVEFIYAALKHMPDFGVEHDLEVYKALINVMP.K.GKFI........PTNLFQAEFM....HYPKQQQCIIDLLEQMEDY...G........VMPDYEMEAMLLNVFGNKGHPLRKYWRMMYWMPKFKN..LSPWPLP.DPVPD....DTL...EIAKLAVERMCTvDLRSKIDVFE.TS.EIKDSLD-----DTWIVS-g......................
B4PVJ6_DROYA/20-243 ...................................vn-RLRCYSTDEGY..PK...QNPN....PN.PRAQ..KPGTK..nLPAVRNPFAAA--QDRTKNSYLTMVEIFQERD.VHRRNHVEFIYAALKNMADFGVERDLEVYKALINVMP.K.GKFI........PTNLFQAEFM....HYPKQQQCIIDLLEQMEDC...G........VMPDHEMEAMLLNVFGRQGHPLRKYWRMMYWMPKFKN..LSPWPLP.DPVPD....DTL...EMAKLALERMCTvDLRSKITVFE.TS.ELKDAID-----DTWIVS-g......................
F1L975_ASCSU/1-66 .....................................------------..--...----....--.----..-----...--------------------------------.-------------------------------------.-.----........----------....-------------------...-........---------------------------MLYWMPKLKH..SNKYLDR.RSIEGr.evGDV...ELAFIALKMMAR.DPGTAFSYVT.VK.DCELP--------------eserwmvsa..............
G1PUE5_MYOLU/39-268 ....................................rGLHCSVATHSSD..SS...LVPR....PP.EPLR..QPAKP...LSPHEELFRPAPDGARNKASFVRAVQNFGQHN.VHKRGHVDFIYLALRKMRDYGVEKDLAVYNLLLDVFP.K.EVFR........PRNVFQKIFV....HYPRQQECGLAVLEQMENH...G........VMPNKETEFLLVQIFGRKSYPMLKFVRMKLWFSRFKN..INPFPVP.RDLPK....DPV...DLAMLGLRHIEP.DLSARVTVYQqMA.SSKDSTGTADPTEQHIVGI.......................
B0W9N2_CULQU/19-242 ......................irscssstkqppppt------------..-P...EEDE....AE.GRKR..KPETK...LMLRTELFEHV--SQKDKRTYIDMVKVFEGRS.VHRRNHVEFIYAALKHMEEFGVQRDLEVYKALINVMP.K.GKFI........PTNIFQAEFM....HYPRQQQVIIDLLEQMEDN...G........VMPDYEMESMLINVFGKKGHPVRKYWRMMYWMPKFKN..LSPWPLP.NPVPD....ESL...DLAKLAIERMCSiDLLSQISLFD.TK.DVADALD-----QTWIVS-g......................
E2APA7_CAMFO/27-244 ....................drtsyirdfhtsrfrsk------------..--...----....--.-DNK..EDDKS...SALVLHAFANA--ERKEKEAYLDIIREYKNNN.ELRRGHVEFIQVALKYMDDFGVNRDLAVYKVLLDVLP.K.GKFV........PTNAFQTLFM....HYPKQQYVAIDLLCKMEKN...C........VIPDVEMQDMLLNIFGKHGAPLKKFWRMMYWMPKFAN..LNPWPCA.RPAPK....DPR...ILARLAISKISSvDVQTKIVEFE.TK.DIEDAIE-----DTWIVS-a......................
G1KTD3_ANOCA/1-211 ....................................n------------..--...----....PD.NSKE..STNRS...LVTVEELFERTSVDAKNRASFQQAVNIFSQRD.IRRRGHVEFIYAALKKMPEFGVEKDIDVYNKILDVFP.K.EVFV........PHNFIQRMFN....HYPRQQECAIEVLEQMENY...G........VMPNKETKLLLLQIFGNKSHPMRKYQRLMYWFPKFKH..INPYPVP.DLLPR....DPV...DLARLSLQRIAA.DLDARVTVYQ.LS.HVEITDSGKSIDHPHIVGI.......................
A8WQY1_CAEBR/4-221 ....................aqlskriitaqirsltn------------..--...----....--.---T..SQEAG...LVHVEKQFEAVVPEKRDKDAFMAAIATFKEK-.-RGRTHVEFINTALKYVKDYRVHKDLDTYKSLLDVFP.K.GKMI........PQTAFQKVFL....HYPQQQNCAVKVLDEMEWH...G........VQPDKEIHDIVVNAFGEWNFATKKVKRMLYWMPKLKH..SNKYLDR.RHLEG....KSLspsELAGIALKMMSR.DPATSISLLK.LS.DNSDPV------D------kwfatsq................
E4YSP2_OIKDI/2-209 ..............................eaylada------------..--...----....--.----..-----...--------EHSYIQEADKRAFYMAVELWKKEAgPGRQGHKDFVVMAIPTISQLGLSKDTKAYMTLLECWP.D.ANYVfaekspiyKQTTSQSTFFiekfEWTSDANLCKHLLRTMERN...G........CLCTNEIYAKVTDLFGIYSDASVLARQQMLFNKRLME..RNPFPID.--APK....DPT...ELAAATLRQASP.GFDRQYH---.--.-------------------rfpmkqrdgnwvrseksgeffes
#=GC seq_cons ....................................p................................tp..p.tps...Ls.hcphFpps..tp+sKssFlpslchFtp+s.l++RGHV-FIYsAL++MtEaGVE+DLtVYptLLDVFP.K.thFh........PpNhhQphFh....HYP+QQpCulslLEQMEsa...G........VhPspEhchlLlplFGc+uaPhpKahRhhYWhP+FKN..lNPaPlP.cslPp....Dsl...-LAphuLc+hss.Dlpuclolap.hs.tsc-shs.....psaIVu........................
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