GenomeNet

Database: Pfam
Entry: EGL-1
LinkDB: EGL-1
Original site: EGL-1 
#=GF ID   EGL-1
#=GF AC   PF11430.4
#=GF DE   Programmed cell death activator EGL-1
#=GF AU   Pollington J
#=GF SE   pdb_1ty4
#=GF GA   20.50 20.50;
#=GF TC   22.10 41.60;
#=GF NC   19.80 17.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   15383288
#=GF RT   Structural, biochemical, and functional analyses of CED-9
#=GF RT   recognition by the proapoptotic proteins EGL-1 and CED-4. 
#=GF RA   Yan N, Gu L, Kokel D, Chai J, Li W, Han A, Chen L, Xue D, Shi Y; 
#=GF RL   Mol Cell. 2004;15:999-1006.
#=GF DR   INTERPRO; IPR021543;
#=GF CC   Initiation of programmed cell death in C.elegans occurs by the
#=GF CC   binding of EGL-1 to CED-9 which disrupts a complex involving
#=GF CC   CED-4/CED-9 and allows CED-4 to activate CED-3, a caspase. It is
#=GF CC   the C terminal domain of EGL-1 which is involved in the
#=GF CC   formation of the complex with CED-9. The formation of the
#=GF CC   complex induces structural rearrangements in CED-9 and EGL-1
#=GF CC   adopts an extended alpha-helical conformation [1].
#=GF SQ   14
#=GS E3MP30_CAERE/60-78    AC E3MP30.1
#=GS E3M1A5_CAERE/71-89    AC E3M1A5.1
#=GS H2W6A1_CAEJA/69-87    AC H2W6A1.1
#=GS G0MQX1_CAEBE/298-317  AC G0MQX1.1
#=GS G0NM76_CAEBE/79-98    AC G0NM76.1
#=GS K7ICB7_CAEJA/12-30    AC K7ICB7.1
#=GS A8WY25_CAEBR/70-89    AC A8WY25.1
#=GS Q9TY06_CAEEL/53-72    AC Q9TY06.1
#=GS B6IM60_CAEBR/51-70    AC B6IM60.1
#=GS EGL1_CAEEL/67-86      AC O61667.2
#=GS EGL1_CAEEL/67-86      DR PDB; 1TY4 D; 52-71;
#=GS EGL1_CAEEL/67-86      DR PDB; 1TY4 C; 52-71;
#=GS G0MQX1_CAEBE/238-256  AC G0MQX1.1
#=GS G0MQX1_CAEBE/124-143  AC G0MQX1.1
#=GS G0MQX1_CAEBE/181-200  AC G0MQX1.1
#=GS E3LTJ5_CAERE/75-94    AC E3LTJ5.1
E3MP30_CAERE/60-78               -EIGTKLTTMCDGFDAKMMS.
E3M1A5_CAERE/71-89               -EIGTKLAAMCDDFDAKMMS.
H2W6A1_CAEJA/69-87               -EIGARIATMCDEFDAELMS.
G0MQX1_CAEBE/298-317             YDIGTKVANMCDDFDAKLMS.
G0NM76_CAEBE/79-98               YKIGTQLAAMCDDFDAEMMS.
K7ICB7_CAEJA/12-30               -EIGARIATMCDEFDAELMS.
A8WY25_CAEBR/70-89               HDIGTKLAAMCDAFDAEMMS.
Q9TY06_CAEEL/53-72               YNIGRKLTVMCDEFDSELMS.
B6IM60_CAEBR/51-70               HTIGKQLSKLCDDFDKEMM-a
EGL1_CAEEL/67-86                 YEIGSKLAAMCDDFDAQMMS.
#=GR EGL1_CAEEL/67-86      SS    HHHHHHHHHHHHHHHHHHHC.
G0MQX1_CAEBE/238-256             HNIGVKQAVMCDNFDKEMM-.
G0MQX1_CAEBE/124-143             HDIGTKLAAMCDDFDDKIMS.
G0MQX1_CAEBE/181-200             HNIGMKLAKMCDDFDDEMM-a
E3LTJ5_CAERE/75-94               YEIGTKLVAMCDDFDAQMMS.
#=GC SS_cons                     HHHHHHHHHHHHHHHHHHHC.
#=GC seq_cons                    a-IGsKLAsMCD-FDAcMMS.
//
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