GenomeNet

Database: Pfam
Entry: EVC2_like
LinkDB: EVC2_like
Original site: EVC2_like 
#=GF ID   EVC2_like
#=GF AC   PF12297.3
#=GF DE   Ellis van Creveld protein 2 like protein
#=GF AU   Assefa S, Gavin OL
#=GF SE   PFAM-B_3668 (release 23.0)
#=GF GA   25.00 25.00;
#=GF TC   50.80 30.80;
#=GF NC   20.60 19.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12468274
#=GF RT   A new gene, EVC2, is mutated in Ellis-van Creveld syndrome.
#=GF RA   Galdzicka M, Patnala S, Hirshman MG, Cai JF, Nitowsky H, Egeland
#=GF RA   JA, Ginns EI;
#=GF RL   Mol Genet Metab. 2002;77:291-295.
#=GF DR   INTERPRO; IPR022076;
#=GF CC   This family of proteins is found in eukaryotes. Proteins in this
#=GF CC   family are typically between 571 and 1310 amino acids in length.
#=GF CC   There are two conserved sequence motifs: LPA and ELH. EVC2 is
#=GF CC   implicated in Ellis van Creveld chondrodysplastic dwarfism in
#=GF CC   humans. Mutations in this protein can give rise to this
#=GF CC   congenital condition. LIMBIN is a protein which shares around
#=GF CC   80% sequence homology with EVC2 and it is implicated in a
#=GF CC   similar condition in bovine chondrodysplastic dwarfism.
#=GF SQ   63
#=GS Q3TNS0_MOUSE/132-556    AC Q3TNS0.1
#=GS H2UVR6_TAKRU/110-535    AC H2UVR6.1
#=GS G3P033_GASAC/53-476     AC G3P033.1
#=GS H3D093_TETNG/239-664    AC H3D093.1
#=GS F1PZ45_CANFA/167-591    AC F1PZ45.1
#=GS D3ZWN3_RAT/147-571      AC D3ZWN3.1
#=GS H3IVA4_STRPU/385-496    AC H3IVA4.1
#=GS G7P586_MACFA/161-585    AC G7P586.1
#=GS F6T7X1_XENTR/123-550    AC F6T7X1.1
#=GS F1S8M6_PIG/1-46         AC F1S8M6.1
#=GS D2HP13_AILME/144-568    AC D2HP13.1
#=GS G3SZ90_LOXAF/87-511     AC G3SZ90.1
#=GS G1LXD6_AILME/162-586    AC G1LXD6.1
#=GS F6Y9V1_HORSE/162-586    AC F6Y9V1.1
#=GS H2UVR7_TAKRU/110-532    AC H2UVR7.1
#=GS Q4W5B1_HUMAN/1-425      AC Q4W5B1.1
#=GS H3IVA4_STRPU/603-740    AC H3IVA4.1
#=GS C3Y3M0_BRAFL/1064-1432  AC C3Y3M0.1
#=GS Q670Z5_TAKRU/236-661    AC Q670Z5.1
#=GS F7HNC9_MACMU/237-661    AC F7HNC9.1
#=GS H2UVR5_TAKRU/110-535    AC H2UVR5.1
#=GS F6R759_CALJA/231-498    AC F6R759.1
#=GS G3P019_GASAC/136-556    AC G3P019.1
#=GS G1P4J3_MYOLU/1-97       AC G1P4J3.1
#=GS G3WNX4_SARHA/65-492     AC G3WNX4.1
#=GS F1NQT5_CHICK/231-662    AC F1NQT5.1
#=GS H0WGP0_OTOGA/125-549    AC H0WGP0.1
#=GS G5B315_HETGA/155-579    AC G5B315.1
#=GS Q3UYX2_MOUSE/147-571    AC Q3UYX2.1
#=GS F6XGD8_MONDO/132-556    AC F6XGD8.1
#=GS F1NTF8_CHICK/134-565    AC F1NTF8.1
#=GS F7HND1_MACMU/157-581    AC F7HND1.1
#=GS H2PCV7_PONAB/237-661    AC H2PCV7.1
#=GS G3SIS4_GORGO/191-616    AC G3SIS4.1
#=GS H2MQ97_ORYLA/136-561    AC H2MQ97.1
#=GS LBN_MOUSE/147-571       AC Q8K1G2.1
#=GS A7SYD8_NEMVE/96-367     AC A7SYD8.1
#=GS H0ZI81_TAEGU/123-549    AC H0ZI81.1
#=GS H3C639_TETNG/239-664    AC H3C639.1
#=GS G3WNX3_SARHA/141-568    AC G3WNX3.1
#=GS F7AIR8_MOUSE/130-554    AC F7AIR8.1
#=GS G1P3L8_MYOLU/1-92       AC G1P3L8.1
#=GS Q4SBX0_TETNG/120-381    AC Q4SBX0.1
#=GS G1S1Y1_NOMLE/1-327      AC G1S1Y1.1
#=GS G1NJC2_MELGA/158-589    AC G1NJC2.2
#=GS F1LVK1_RAT/130-554      AC F1LVK1.1
#=GS H3J3Q0_STRPU/383-828    AC H3J3Q0.1
#=GS E6ZG52_DICLA/142-567    AC E6ZG52.1
#=GS D3ZWT7_RAT/148-572      AC D3ZWT7.1
#=GS Q4SBX0_TETNG/67-123     AC Q4SBX0.1
#=GS G3RCY4_GORGO/190-614    AC G3RCY4.1
#=GS LBN_HUMAN/237-661       AC Q86UK5.1
#=GS E9PFT2_HUMAN/157-413    AC E9PFT2.1
#=GS LBN_BOVIN/137-561       AC Q8MI28.1
#=GS H0VEZ5_CAVPO/234-660    AC H0VEZ5.1
#=GS G1TBK9_RABIT/233-659    AC G1TBK9.1
#=GS H2QP60_PANTR/237-661    AC H2QP60.1
#=GS F7HNC8_MACMU/157-581    AC F7HNC8.1
#=GS F6R759_CALJA/501-607    AC F6R759.1
#=GS G7MSJ3_MACMU/208-632    AC G7MSJ3.1
#=GS C3Y3M0_BRAFL/480-919    AC C3Y3M0.1
#=GS E1BES3_BOVIN/137-563    AC E1BES3.2
#=GS Q5QGM3_CHICK/231-662    AC Q5QGM3.1
Q3TNS0_MOUSE/132-556               ..........GECYSVSYTASLDPTALG.TG.ES...LDLPARLIFQSPSQNRT---...-QL..........KAPFTITVEEKIMVLPNHGLHAAGFIAAFLISLLLTVAALF.FLARGRCLQGGMLS..RCR...IQHPE........NKL..EPSP.FTSANGVSQD..LSLNDQVVAILTSEEPGSMLQALEELE.....IATLNQAD.....ADLEACRNQISKD..IIALLMK.NLVSG.GHLSPQTERKMAAAFKKQFLLLENEIQ.EEYERKMLALTAECDLEMRKK.TENQYQREMVAMEEAEEVLKR.VSERSAAECS.SLLRTLHGLEQEDMQRSLTLDQAEDFAQAHRQLAVF........QRNELHSIVYTQIQSAVSKGELRPEVAKMMLQDYSKTQ..ESVEELMDFFQATKRYHLSKRFGHREYLVQRLQAMETRVQGLLNTAATQLTSLIHKHERAGYLDEDQMETLLERAQTETFSIKQKLDNDLK...................
H2UVR6_TAKRU/110-535               ..........GSQVIVNYTAQIRSHKI-.--.EV...LDLPAFLTFSNASQNDVSMF...GPL..........TTNLTLRVNSTDRIHPNHSAHFAGFVVGFFVTIVLLSLGFL.AMNLTGSRTRLNLL..QQR...RKRED........SDP..DDAD.CNIDETIKEE..AAFEDKIVDTMVLEEPQNMYQSLENLE.....MSTLLRAT.....NNMEATRIQIYKD..VMSSLLG.GLLSQ.GHASMQTQQRLLSVLYGQLLGMEGRLK.EERAARMAALANQCNLESREE.MEAEHHRETAEKAQAELLYKQ.ADQQELLRCS.VLLEKLHKLRQSRLQAKLLVQHEEASAKVQRQIIEW........RRVELHKIFSEELEEATRMGEMERSTAKSLQHEYFDCQ..DHLEEVLDVVLANQRYVLAERHAQRKFLVHSLHSLNSLISDTFSITSNNLDNWFCQIRRGSTLPVEKVDQLQDEAQKELVMVRQRLDEAL-s..................
G3P033_GASAC/53-476                ..........GSQVVVNYTAHIRNHKS-.--.EV...MDLPAFVTFSNASQVFK--R...CTF..........LVFMSYTFDLMRSIHPNHGVHLAGVVAGFFGTLMLLSLGFL.AVNLIGLRTRLNLF..QQK...RNRGD........SEP..EYAE.CNMSEAVKDE..AAFEDKMVDTMVLEDPQNMYQALENLQ.....MSTLLHAT.....NNLEATRIQIYRD..VMSSLLG.SLRSR.GQASAQAQQRLLSVLHGQMLGMEGRLK.EERGARMAALAGRCNQETREE.MEAEHRTEAAQKAQAELLCQH.ANQQELLHCS.VLLEKLHKLSQSRLQRILLVRHEEASGKVQRQIVEW........RRVELHKIFSEELEEATRMGELEKSAAKSLQHDYFASQ..DQLEEVLDVVLANQRYVLAERHAQRKFLVHSLHSLNNLISDSFSSTSSNLDSWFTHIRRGGSVPSEQLDQLQDKAQKELVMVRQRLEEAL-s..................
H3D093_TETNG/239-664               ..........GSQVIVNYTAHIRSHKI-.--.DL...LDLPAFLTFSNASQNDVSMF...GPL..........TANLTLRVNSTDRIQPNHDAHFAGFVVGFFVTIVLLSLGFL.AINLTDSRTRLNIL..QQN...KKRRD........SDI..NNAD.CDLDESFKEE..AAFEDKIVDIMVLKRGFHCMNNSTSLE.....MSTLLRAT.....NNLEVTRIQIYKD..VMSLLLG.DLPSR.GHTSVQTQQRLLSVLDGQLLGMEGRLK.EERGARMTALANRCNLESREE.MEAEHHREAAEKAQAKLLCKQ.ADQQELLHCS.VLMEKLHKLKQSQLQDKLLVQHEEASAKVQRQIIEW........RRVELHKIFSEELEESTRMGEMERKTAESLQHEYFDCQ..DYLEEVLDMILANQRYVLAERHAQRKFLVHSLHSLNGLISDTFSITSDSLDNWFSQIKRGSTLPAEQVDQLQDKAQKELVMVRQRLDETM-s..................
F1PZ45_CANFA/167-591               ..........GDSFSVSYTASIKAGEVG.SG.EV...LLLPAQLTFQSSAQNKT---...-QL..........KALFTITAEEKIKVVPNHGLHAAGFFTASVISFVLTWVTLF.FMARYQCLKGGPFA..RHQ...VQHHE........SKL..EHSQ.FTSADGVNED..LALNDQMIDILSSEDPGSMLQALEELE.....IATLNRAD.....SDLEACRTQISRD..IIALLLK.NLSSS.GHLSPQVERKMSAVFKKQFLLLEKEIQ.EEYDRKMVALTAECDLEMRKK.TESQYQREMAAMEVSEELLKR.GGTKSAVECS.GLLRTLHGLEQVHLRRSLALQQEEDFAKAHRQLAIF........QRNELHNIFFTQIKSAVCQGELKPEAAKMLLQDYSDVQ..EKLEELMDFFQASKRYHLSKRFGHREYLVQNMQSSEIRVQGLLSAADAQLTLFIQKHERAGYLDEEQMEALLERARMEVFSIKQKLDNDLK...................
D3ZWN3_RAT/147-571                 ..........GECYSVSYMASLDPTALG.PG.ES...LDLPAQLIFQRPSQNRT---...-QL..........RARFTITVEEKIMVLPNHGLHTAGFIAAFLISFLLTLAALF.FLARGRCLQGSMLL..RCR...VQHPE........NKL..EPSP.FTSANGVSQD..LSLNDQLVAILTSEEPGSMLQALEELE.....IATLNQAD.....ADLEACRNQISKD..IIALLMK.NLISG.GHLSLQTERKMAAAFKKQFLLLENEIQ.EEYERKMLALTAECDLEVRKK.TENQYQREMVAMEEAEEVLKR.VSERSAAECS.SLLRTLHGLEQEDLQRSLTLQQAEDFAQAHRQLAVF........QRNELHSIVYTQIQSAVAKGELRPEVAKMLLQDYSKTQ..ESIEELMDFFQATKRYHLSKRFGHREYLVQRLQAMETRVQGLLSTAATQLTSLIHKHERAGYLDEDQMEMLLERAQTETFSIKQKLDNDLK...................
H3IVA4_STRPU/385-496               ..........GETAVLSYNARLTQSSVD.DNlET..dIQLESQLTWSSLPADEETNThpgTSFgp.....itdSICITQAITYEESLLYNHGLPALFFFVALILALVLVILCCF.IYAKM---------..---...-----........---..----.----------..---------------------------.....--------.....-------------..-------.-----.---------------------------.---------------------.---------------------.----------.------------------------------------........--------------------------------------..-------------------------------------------------------------------------------------------saggiyaivqp........
G7P586_MACFA/161-585               ..........GDAFAVSYAATLQAGDLG.NG.ES...LKLPAQLTFQSSSQNRT---...-QL..........KALFSITAEESITVLPHHGLHAAGFFIAFLLSLVLTWAALF.LMVHYQCLKGSMLT..RHR...VWQYD........SKL..EPLP.FTSADGVNED..LSLNDQMIDILSSEDPGSMLQALEELE.....IATLNRAD.....ADLEACRTQISKD..IIALLLK.NLTSS.GHLSPQVERKMSDVFKKQFMLLENEIQ.EEYDRKMVALTAECDLETRKK.MENQYQREMMAMEEAEELLKR.ASERSAVECN.SLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVF........QRNELHRIFFTQIKSAILKGELKPEAAKTLLQNYSKIQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLK...................
F6T7X1_XENTR/123-550               ..........GEYLLIKYNASLSSGLAT.DG.LQ...LSLPAQLSFQNSSAVAG-TS...LRL..........MAAFTVTAKENIKVLPNHGLHALGFVIGFLVSFLLTCAVLL.VLRYTKRLNCRCLG..NLH...GTNCE........PKL..GKSQ.SNSPDNVNED..FNMPDKMIDILAFEEPENMLQALDDSE.....IVNLTHAD.....AYLEACRIHVCKD..IIGISLK.NMAAT.VHLPHYEVKRLTAAMSEQWINLEKQIQ.EEHQRKIVALTAECHLDTRKQ.VDMQERKQKAVYEEAEEKFRH.AGEKSLTEYR.LLLDKLHDMERAEMMKLLMYKQEEDFAKARRELSVC........HRTELLGIFSEQLHDSVAKGNITADAGTAVIENHFKIQ..EEAEDLLDFIQADKKCRMNRTLAARKNIIYIMQLCDSRSRCLLNTAAAQIASLINKTERAGHMNENQAELLMCRAQAEVSRVKQKMDNVLK...................
F1S8M6_PIG/1-46                    ..........------------------.--.--...--------------------...---..........-------------VLPNHGLHAMGFFVALILSLLLTWAVLF.FMVRYQCLKGSLLS..RHR...-----........---..----.----------..---------------------------.....--------.....-------------..-------.-----.---------------------------.---------------------.---------------------.----------.------------------------------------........--------------------------------------..-------------------------------------------------------------------------------------------v..................
D2HP13_AILME/144-568               ..........GDSFSVSYTASIKAGEVG.SG.EV...LMLPAQLTFQSSAQNRT---...-QL..........KALFTITAEEKIKVVPNHGLHVAGFFIASIVSFVLTWVTLF.FLARYQCLKGGLPT..RHQ...VQHHE........SKL..EHSQ.FTSADGVNED..LALNDQMIDILSSEDPGSMLQALEELE.....IATLNRAD.....SDLEACRTQISRD..IIALLLK.NLASS.GHLSPQVERRMGAAFKKQFLWLEKEIQ.EEYDRKMVALTAECDLETRKK.TESQYQREMAAMEEAEGLLKR.VSERSAMECS.SLLRTLHGLEQVHLRRSLALQQEEDFAKAHRQLAIF........QRHELHNIFFTQIKSAIFQGELKAEAAKMLLQDYADIQ..EKLEELMDFFQASKRYHLSKRFGHREYLVQNMQSSETRVQGLLSTADTQLTLFIQKHERAGYLDEEQMETLLERVQTEVFSIKQKLDNDLK...................
G3SZ90_LOXAF/87-511                ..........GDAFAVSYIALLVARHVR.DG.ET...LLLPAQLTFHSSSQNRT---...-QL..........KALFAITAEEKVTVLPNHGLHAAGFFVAFMVSLALTWITLF.FMVRYQCLKGNMLN..RHR...VQHQG........SKL..EHSQ.FTSADGVNED..LALNDQMVDILSSEDPGSMLQALEDLE.....IATLNQAD.....SNLEACRTQISKD..IIALLLK.NLTSR.GHLSPQVERRMGAVFKKEFLLLENEIQ.EEYDRKMVALTAECDLESRKK.TESQYQREMVAMEEVEELLKR.VSERSAAECS.NLLRTLHGLEQERLRRALALQQEDDFAKAHRQLAIF........QRHELQRTFFTQIQSALVKGELKPEGAEMLLQDYSEMQ..GNVEELMDFFQATKRYHLSKRFGHREYLVQNMQSSEIRARGLLSAAAAQLTHLIQKHERAGYLDEEQMEMLLERAQTEVFSIKQKLDNDLK...................
G1LXD6_AILME/162-586               ..........GDSFSVSYTASIKAGEVG.SG.EV...LMLPAQLTFQSSAQNRT---...-QL..........KALFTITAEEKIKVVPNHGLHVAGFFIASIVSFVLTWVTLF.FLARYQCLKGGLPT..RHQ...VQHHE........SKL..EHSQ.FTSADGVNED..LALNDQMIDILSSEDPGSMLQALEELE.....IATLNRAD.....SDLEACRTQISRD..IIALLLK.NLASS.GHLSPQVERRMGAAFKKQFLWLEKEIQ.EEYDRKMVALTAECDLETRKK.TESQYQREMAAMEEAEGLLKR.VSERSAMECS.SLLRTLHGLEQVHLRRSLALQQEEDFAKAHRQLAIF........QRHELHNIFFTQIKSAIFQGELKAEAAKMLLQDYADIQ..EKLEELMDFFQASKRYHLSKRFGHREYLVQNMQSSETRVQGLLSTADTQLTLFIQKHERAGYLDEEQMETLLERVQTEVFSIKQKLDNDLK...................
F6Y9V1_HORSE/162-586               ..........GDSFSVNYTASLEARDVG.SG.EI...LMLPARLTFQSSSPNRT---...-QL..........KALFTIIAEEKIKILPDHGLHAAGFFTAFIGSLVLTWVALF.FLVRCECLRGSRLG..RRQ...VQHHE........SRL..EHSQ.FISADGVNED..LALNDQMVDILSSEDPGSMLQALEELE.....IATLNRAD.....SDLEACRTQISKD..IIALLLK.NLTSS.GHLSPQAERRMAAVFKKQFLLLEKEIQ.EEYDRKMVALTAECDLETRKK.TENQYQREMAAMEEAEELLKR.VSERSAVECS.DLLRALHGLEQEQLRRSLALQQEEDVAKAHRQLAIF........QRNELHSIFFTQIKSAIFKGELKPEAAKMLLQDYSKIQ..ENVEELMDFFQASKRYHLSKRFGHRECLVQNMQSSETRVQGLLSAAAAQLSLLIQKHERAGYLEEHQMEVLLERAQTEVFSIKQKLDNDLK...................
H2UVR7_TAKRU/110-532               ..........GSQVIVNYTAQIRSHKI-.--.EV...LDLPAFLTFSNASQNDVSMF...GPL..........TTNLTLR------IHPNHSAHFAGFVVGFFVTIVLLSLGFL.AMNLTGSRTRLNLL..QQCkypRKRED........SDP..DDAD.CNIDETIKEE..AAFEDKIVDTMVLEEPQNMYQSLENLE.....MSTLLRAT.....NNMEATRIQIYKD..VMSSLLG.GLLSQ.GHASMQTQQRLLSVLYGQLLGMEGRLK.EERAARMAALANQCNLESREE.MEAEHHRETAEKAQAELLYKQ.ADQQELLRCS.VLLEKLHKLRQSRLQAKLLVQHEEASAKVQRQIIEW........RRVELHKIFSEELEEATRMGEMERSTAKSLQHEYFDCQ..DHLEEVLDVVLANQRYVLAERHAQRKFLVHSLHSLNSLISDTFSITSNNLDNWFCQIRRGSTLPVEKVDQLQDEAQKELVMVRQRLDEAL-s..................
Q4W5B1_HUMAN/1-425                 ..........GDAFAVSYAATLQAGDLG.NG.ES...LKLPAQLTFQSSSRNRT---...-QL..........KVLFSITAEENVTVLPHHGLHAAGFFIAFLLSLVLTWAALF.LMVRYQCLKGNMLT..RHR...VWQYE........SKL..EPLP.FTSADGVNED..LSLNDQMIDILSSEDPGSMLQALEELE.....IATLNRAD.....ADLEACRTQISKD..IIALLLK.NLTSS.GHLSPQVERKMSAVFKKQFLLLENEIQ.EEYDRKMVALTAECDLETRKK.MENQYQREMMAMEEAEELLKR.AGERSAVECS.NLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVF........QRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLK...................
H3IVA4_STRPU/603-740               ........ne------------------.--.--...--------------------...---..........-----------------------------------------.--------------..---...-----........---..----.----------..---------------------------.....--------.....-------------..-------.-----.---------------------------.---------------------.---------------------.----------.-----------------------------NKEYATK........KRIAMKAVQQEYMDKAILQGKLDEDQARRLLSEHQQDM..STVERLMDEEMSRQRMSLEEKLARRKLLAKATESQEEHHSALLNTMASQTMTAVSDLEQSEQLGQEEAKAYVEKLMKEVKGIKENYEKER-r..................
C3Y3M0_BRAFL/1064-1432             ..........GEELLLSFQAEMECKERE.CA.ESspnLTIPANVTYRSVAVQQTANS...---..........-----------TQLFRNYGYIGLALIVFLLVGIVVGLLCCF.LLGRTRGMQVRPLK..RQR...YRGSDsegelddvSLL..KQQL.QERISLLSEEsqARMDDD-IETIRVEMLQERAQALKDQEerlggLLSSLQMErarelATIEEQREALNKL..T-TNLVD.ELSDK.GVLTDPECKKVIEQHKKDVDKLEKKLH.HQRQRQEEELKKKLTEKMMQR.EKSMLQLHEE---RLREIHSQ.EASKTAARFKmAAMKNKYMMESEKQRQKMERGVEQNLEDYRRQWDMK........RKQALQEQELKFISGLVKTGRFEREELFSVLTLLFPHN..TDISQIL------------------------------------------------------------------------------------ekiyteeshssdesdggrr
Q670Z5_TAKRU/236-661               ..........GSQVIVNYTAQIRSHKI-.--.EV...LDLPAFLTFSNASQNDVSMF...GPL..........TTNLTLRVNSTDRIHPNHSAHFAGFVVGFFVTIVLLSLGFL.AMNLTGSRTRLNLL..QQR...RKRED........SDP..DDAD.CNIDETIKEE..AAFEDKIVDTMVLEEPQNMYQSLENLE.....MSTLLRAT.....NNMEATRIQIYKD..VMSSLLG.GLLSQ.GHASMQTQQRLLSVLYGQLLGMEGRLK.EERAARMAALANQCNLESREE.MEAEHHRETAEKAQAELLYKQ.ADQQELLRCS.VLLEKLHKLRQSRLQAKLLVQHEEASAKVQRQIIEW........RRVELHKIFSEELEEATRMGEMERSTAKSLQHEYFDCQ..DHLEEVLDVVLANQRYVLAERHAQRKFLVHSLHSLNSLISDTFSITSNNLDNWFCQIRRGSTLPVEKVDQLQDEAQKELVMVRQRLDEAL-s..................
F7HNC9_MACMU/237-661               ..........GDAFAVSYAATLQAGDLG.NG.ES...LKLPAQLTFQSSSQNRT---...-QL..........KALFSITAEESITVLPHHGLHAAGFFIAFLLSLVLTWAALF.LMVHYQCLKGSMLT..RHR...VWQYD........SKL..EPLP.FTSADGVNED..LSLNDQMIDILSSEDPGSMLQALEELE.....IATLNRAD.....ADLEACRTQISKD..IIALLLK.NLTSS.GHLSPQVERKMSDVFKKQFMLLENEIQ.EEYDRKMVALTAECDLETRKK.MENQYQREMMAMEEAEELLKR.ASERSAVECN.SLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVF........QRNELHRIFFTQIKSAILKGELKPEAAKTLLQNYSKIQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLK...................
H2UVR5_TAKRU/110-535               ..........GSQVIVNYTAQIRSHKI-.--.EV...LDLPAFLTFSNASQNDVSMF...GPL..........TTNLTLRVNSTDRIHPNHSAHFAGFVVGFFVTIVLLSLGFL.AMNLTGSRTRLNLL..QQR...RKRED........SDP..DDAD.CNIDETIKEE..AAFEDKIVDTMVLEEPQNMYQSLENLE.....MSTLLRAT.....NNMEATRIQIYKD..VMSSLLG.GLLSQ.GHASMQTQQRLLSVLYGQLLGMEGRLK.EERAARMAALANQCNLESREE.MEAEHHRETAEKAQAELLYKQ.ADQQELLRCS.VLLEKLHKLRQSRLQAKLLVQHEEASAKVQRQIIEW........RRVELHKIFSEELEEATRMGEMERSTAKSLQHEYFDCQ..DHLEEVLDVVLANQRYVLAERHAQRKFLVHSLHSLNSLISDTFSITSNNLDMFCASATRGSTLPVEKVDQLQDEAQKELVMVRQRLDEAL-s..................
F6R759_CALJA/231-498               ..........GDAFAVSYTATLQAGDIW.NG.ES...LKLPAQLTFQSLSRNRT---...-QL..........KALFTITAEENIRVLPNHGLHAAGFFSAFLVSLVLTWAALF.LMVRYQCLKGNLLT..RRR...VWRHE........SKL..EPLP.FTSADGVNED..LSLNDQMIDILSSEDPGSMLQALEELE.....IATLNRAD.....ADLEACRTQISKD..VLALLLK.NLTNN.GHLSPQVERKMSAVFKKQFLLLDNEIQ.EEYDRKMVALTAECDLETRKK.MENQYQREMMAMEEAEELLKR.ASERVRQ---.------------------------------------........--------------------------------------..-------------------------------------------------------------------------------------------sslnkihtkyc........
G3P019_GASAC/136-556               ..........GSQVVVNYTAHIRNHKS-.--.EV...MDLPAFVTFSNASQNDVSMF...GPL..........TANLTLR------IHPNHGVHLAGVVAGFFGTVFSQLFYLFfIYFRYASRQCACIF..LQQ...RNRGD........SEP..EYAE.CNMSEAVKDE..AAFEDKMVDTMVLEDPQNMYQALENLQ.....MSTLLHAT.....NNLEATRIQIYRD..VMSSLLG.SLRSR.GQASAQAQQRLLSVLHGQMLGMEGRLK.EERGARMAALAGRCNQETREE.MEAEHRTEAAQKAQAELLCQH.ANQQELLHCS.VLLEKLHKLSQSRLQRILLVRHEEASGKVQRQIVEW........RRVELHKIFSEELEEATRMGELEKSAAKSLQHDYFASQ..DQLEEVLDVVLANQRYVLAERHAQRKFLVHSLHSLNNLISDSFSSTSSNLDSWFTHIRRGGSVPSEQLDQLQDKAQKELVMVRQRLEEAL-s..................
G1P4J3_MYOLU/1-97                  ......dflf------------------.--.--...--------------------...---..........-----------------------------------------.--------------..---...-----........---..----.----------..---------------------------.....--------.....-------------..-------.-----.---------------------------.---------------------.---------------------.----------.------------------------------------........------------------------------------EQ..EEVEELMDFFQASKRYHLSKRFGHREYLVQNMQSAETRVQGLLSAAAAQLTLLIQKHERAGYLDEEQTEELMERAQTEVFSIKQKLDNDLK...................
G3WNX4_SARHA/65-492                ..........GDVYTVSYRARLTAKEAG.DG.KI...LSLPAQLTFQSPSLNKT---...-QL..........KALLTVRGQEKAKVSPNHGAHAAGFFIAFLVSLALTCIIFL.FMSQSRCFRWILCN..KNR...VEQSPh.....qeSKL..EYSQ.FTFVDGVSEE..FAISDQIIDILSAEEPGSMVQALEDME.....IATLTRAD.....ADLQACRMQISKD..IIGMLLK.NLTLS.GNLSPHMEKRMSSVFKKQFLMMETEVQ.EEYDRKMVALTAECTLEMRKK.TEAQCQREMAAMEEAEELLKH.VSERSALEYR.NLLHNLHRREQDHLRKSLLLKREEDFAKAYRELAIF........QRNELHNIFFTQIKSAVLKGDLKLETAKMLLQDYSKIQ..ENIEELMDFLQANKKYHLSKRFGYTQYLIQSIQSLGTRDQSLLNTATAQIMSLIHKNERAGYLDEDQMETLLARAQAEVLSVQQKLENDLK...................
F1NQT5_CHICK/231-662               ..........GEYFAINYTALLDAKKTW.KG.RV...LTLPAQLTFRSSSQNQTDLV...-SL..........TTLFTITEEEKTEVSYSHAIHASGFFIAFFVSLVLTCAVFF.ILYRTQLLRWSFYS..ENQ...EIQHEls....qnHKL..EHSQ.FSSGDLFSED..VIMNDQIIDILTFEESGNMLQALEDLE.....VASLTRAD.....ADLEAYRMQICKE..VIAIMMK.NMVLS.HSLIPHVEKRMSSIFKKQFLTMEREFQ.EEYERKVVALTAECNLETRKK.MEAQRQKERAANEEAEELIRK.VNEMPAVEYK.SLLDRLHSLEQDHLKRFLLVKQEEYFAKAYRQLAVS........RRKELHNIFFTQITNATFKGELKLEIAKSLVEDYSKIQ..GDIEELMDFLQASKKYHLNRRFAYREYLIKKIQLRDSQASALINAAATQILNLINKMERAGHLHESHLGMLLDRAEAEINSVKQKFNHDLK...................
H0WGP0_OTOGA/125-549               ..........GDSFEVSYTASLQPEGLR.PG.ES...LKLPAHLTFQSTSLNRT---...-QL..........KALFTITAEEKITVLPHHGLHAAGFFAAFLLSLVLTWVGLF.FMVRYQCLQGNVFT..RHR...VGHHE........SKL..EPLL.FTLEDGVNED..LSLNEQLIDILSSEDSGSTLQALKELE.....IATLNRAD.....ADLEVCRTQISKD..IIALLLK.NLTSN.GHLSPQVERRMGTIFKRQFLLLENEIQ.EEYDRKMVALTAECDLETRKK.TENQYQREMAAMEEAEELLKR.ASERSATECN.NLLRTLHCLEQEHVRKSLALQQEEDFAAARRQLAVC........QRGELHGIFFTQVKSAVLKGDLKPEVAKMLLQNYSKIQ..ENVEELMDFFQATKRYHLSKRFGHREYLVQNLQSSETRAQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEIFSVKQKLDYDLK...................
G5B315_HETGA/155-579               ..........GDSYLVSYSASLERGAVV.TG.ER...LSLPAQLTFQSSSRNRT---...-QL..........QALFTITVAERITVLPHHGLHAAGFFIAFLISLVLSWVALF.FLARYWCLPGSLLA..GHQ...TQHPE........SKL..EPLP.FASADGISED..LSLNDQMIDILTSEDPGSMLQALEELE.....IATLNRAD.....ADLEACRTQISKD..IIGLLLR.SLTSG.GHLSPQVERRIGSVLKKQFLLLENEVQ.EEYDRKMLALTAECDLEMRKK.TENQYQKEMVAMEEAEELLKC.VSERSAAEYS.SLLRTLHGLEQEHLWRSLALHQEEDFAQAHRQLAVF........QRNELHSIFFAQMKNAIFKGELKPEAAKMLLQDYSKLQ..ENIEESMDFLQATKRYHLSKRFGHREYLVQNLRSTETRVQGLLSAAAAQLTQLIQKHERAGYLDEDQMEMLLERVQMEVFSIKQKLDNDLK...................
Q3UYX2_MOUSE/147-571               ..........GECYSVSYTASLDPTALG.TG.ES...LDLPARLIFQSPSQNRT---...-QL..........KAPFTITVEEKIMVLPNHGLHAAGFIAAFLISLLLTVAALF.FLARGRCLQGGMLS..RCR...IQHPE........NKL..EPSP.FTSANGVSQD..LSLNDQVVAILTSEEPGSMLQALEELE.....IATLNQAD.....ADLEACRNQISKD..IIALLMK.NLVSG.GHLSPQTERKMAAAFKKQFLLLENEIQ.EEYERKMLALTAECDLEMRKK.TENQYQREMVAMEEAEEVLKR.VSERSAAECS.SLLRTLHGLEQEDMQRSLTLDQAEDFAQAHRQLAVF........QRNELHSIVYTQIQSAVSKGELRPEVAKMMLQDYSKTQ..ESVEELMDFFQATKRYHLSKRFGHREYLVQRLQAMETRVQGLLNTAATQLTSLIHKHERAGYLDEDQMETLLERAQTETFSIKQKLDNDLK...................
F6XGD8_MONDO/132-556               ..........GDFYSVSYSALLKAKEAR.NS.KI...LSLPAHLTFQSLSLERA---...-EL..........KALLTIRRQEKTKVSPNHGAHTAGFFIAFLVSLVLTFVIFL.FMSQSQCFKWNICN..KNR...SPHQE........SKL..EYSQ.FTSVDGVSEE..FAIGDQIIDILLSEEPASMVQALEDME.....IATLTRAD.....VDLQACRMQISKD..IIGMLLK.NLILS.GNLSPHMEKRMSSVFKKQFLKMETEVQ.EEYDRKMVALNAECNLEMRKK.TEAQCQREMVAMEEAEELLKR.VSERSALEYR.NLLHNLHRREQDHLRKSLLLKREEDFAKAYRELAIF........QRNELHNIFFTQIKSAVLKGDLKLETTKMLLQDYSKIQ..ENIEELMDFLQANKKYHLSKRFGYREYLIQSIQSLETWNQSLLNTATAQITSLIHKNERAGYLDEDQMETLLARAQAEVLSVQHKLENDLK...................
F1NTF8_CHICK/134-565               ..........GEYFAINYTALLDAKKTW.KG.RV...LTLPAQLTFRSSSQNQTDLV...-SL..........TTLFTITEEEKTEVSYSHAIHASGFFIAFFVSLVLTCAVFF.ILYRTQLLRWSFYS..ENQ...EIQHEls....qnHKL..EHSQ.FSSGDLFSED..VIMNDQIIDILTFEESGNMLQALEDLE.....VASLTRAD.....ADLEAYRMQICKE..VIAIMMK.NMVLS.HSLIPHVEKRMSSIFKKQFLTMEREFQ.EEYERKVVALTAECNLETRKK.MEAQRQKERAANEEAEELIRK.VNEMPAVEYK.SLLDRLHSLEQDHLKRFLLVKQEEYFAKAYRQLAVS........RRKELHNIFFTQITNATFKGELKLEIAKSLVEDYSKIQ..GDIEELMDFLQASKKYHLNRRFAYREYLIKKIQLRDSQASALINAAATQILNLINKMERAGHLHESHLGMLLDRAEAEINSVKQKFNHDLK...................
F7HND1_MACMU/157-581               ..........GDAFAVSYAATLQAGDLG.NG.ES...LKLPAQLTFQSSSQNRT---...-QL..........KALFSITAEESITVLPHHGLHAAGFFIAFLLSLVLTWAALF.LMVHYQCLKGSMLT..RHR...VWQYD........SKL..EPLP.FTSADGVNED..LSLNDQMIDILSSEDPGSMLQALEELE.....IATLNRAD.....ADLEACRTQISKD..IIALLLK.NLTSS.GHLSPQVERKMSDVFKKQFMLLENEIQ.EEYDRKMVALTAECDLETRKK.MENQYQREMMAMEEAEELLKR.ASERSAVECN.SLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVF........QRNELHRIFFTQIKSAILKGELKPEAAKTLLQNYSKIQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLK...................
H2PCV7_PONAB/237-661               ..........GDAFVVSYAATLQAGDLG.NG.ES...LKLPAQLTFQSSSRNRT---...-QL..........KALFSITAEENITVLPHHGLHAAGFFIAFLLSLVLTWAALF.LMVHYQCLKGNMFT..RHR...VWQYE........SKL..EPLP.FTSADGVNED..LSLNDQMIDILSSEDPGSTLQALEELE.....IATLNRAD.....ADLEACRTQISKD..IIALLLK.NLTSS.GHLSPQVERKMSAVFKKQFLLLENEIQ.EEYDRKMVALTAECDLETRKK.MENQYQREMMAMEEAEELLKR.ASERSAVECN.NLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVF........QRNELHSIFFTQIKSAIFKGELKPEAAKTLLQNYSKIQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLK...................
G3SIS4_GORGO/191-616               ..........GDAFAVSYAATLQAGDLG.NG.ES...LKLPAQLTFQSSSRNRT---...-QL..........KALFSITAEENITVLPHHSLHAAGFFIAFLLSLVLTWAALF.LMVRYQCLKGNMLT..RHR...VWQYE........SKL..EPLP.FTSADGVNED..LSLNDQMIDILSSEDPGSMLQALEDIS.....IIINGRSL.....VCVEICDTLLTKN..SIFLCLTlGLTTA.THLSLKVKRKMSAVFKKQFLLLENEIQ.EEYDRKMVALTAECDLETRKK.MENQYQREMMAMEEAEELLKR.ASERSAVECS.NLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVF........QRNELRSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLK...................
H2MQ97_ORYLA/136-561               ..........GSYVAVNYTAFVRSHKS-.--.EI...LQLPAFLTFSNASQNDVCMF...GPL..........QANLTLRVNSTDAISPNHRVHFAGFAAGFLVASALLSVGFL.AMNLAGPNAGLRLL..QQR...RNRGD........SDP..EYAD.CSMREAIKDE..ATFEDNMVDVMVLEEPQNMYQALENVE.....MSTLLRAS.....SNLELIRIQIYKD..VMSCLLG.GLQSE.RRTSIRAQERLLSVLHGQLLAMEGRLK.EDRGARMAALAGHCNLETREE.MEAEHRREAAEKARAERLCQH.ADQQELLRCS.VLLEKLHKLNQSRLQRTLLVRHEEASAKVQRQIVER........RRVELHKIFSEELEEAVRMDELEKSAAKSLLHKYFTCQ..DELEEVLDVVVANQRYVLSERSAQRRFLVHSLHSLNGLISDSFSTSSRTLDSWFAHVRRGSLIPAEHIEPLQEKAQKELVMVRQRLDETL-n..................
LBN_MOUSE/147-571                  ..........GECYSVSYTASLDPTALG.TG.ES...LDLPARLIFQSPSQNRT---...-QL..........KAPFTITVEEKIMVLPNHGLHAAGFIAAFLISLLLTVAALF.FLARGRCLQGGMLS..RCR...IQHPE........NKL..EPSP.FTSANGVSQD..LSLNDQVVAILTSEEPGSMLQALEELE.....IATLNQAD.....ADLEACRNQISKD..IIALLMK.NLVSG.GHLSPQTERKMAAAFKKQFLLLENEIQ.EEYERKMLALTAECDLEMRKK.TENQYQREMVAMEEAEEVLKR.VSERSAAECS.SLLRTLHGLEQEDMQRSLTLDQAEDFAQAHRQLAVF........QRNELHSIVYTQIQSAVSKGELRPEVAKMMLQDYSKTQ..ESVEELMDFFQATKRYHLSKRFGHREYLVQRLQAMETRVQGLLNTAATQLTSLIHKHERAGYLDEDQMETLLERAQTETFSIKQKLDNDLK...................
A7SYD8_NEMVE/96-367                ......merl------------------.--.--...--------------------...---..........-----------------------------------------.--------------..---...-----........---..----.----------..---------------------------.....--------.....-----------RK..VMGLLAK.KLRVK.RDISTSQEKNFIAKLKSEIAGVSQRLG.ADFKRRSAEVRRKIQRMLKAA.HADMVRRQAKEIKETEAKIKGlVSQRERRDII.DVLRRRHAKEEEDLRKKFKLEEDVEMERLRKKAKFFyptgscsyKRFTMKEAQSKLLQDLIKEAEFNEDQASALVKEHLGNM..AAVDKAMDEEKSRRVVALEMRLAERRALAIQKHDESDFNKRLVQSLEEQHENTMQSLVSSSKISEAEANAYIERYKKEVDALKEKTEKE--krk................
H0ZI81_TAEGU/123-549               ..........GEHFAINYSALLDAEEMW.HG.RV...LTLPVKLTFKSSSQVFYSLF...--Y..........SALHKFCKKPVSRILYNHAISASAFFIAFFISLVLTCAVFF.IIYRTQVLKWSFCS..KNQ...VSDQN........HKL..EHSQ.FNSGELFSED..IIMNDQIIDILSFEEPGSMRQALEDLE.....VASLTRAD.....ADLEANRTQICKE..VIAMMFK.NMVLN.HNLFPHVEKKISSVFRKQFLAMEEEIQ.EEYERKMVALTAECNLETRKT.MEAQCQKARAVNEEAEELMKK.INEKPAIEYR.SLLDKLHRLEQDCLKRFLFVKQEEYFAKAYRELAVT........QRKELHTIFFTQIINATSRGELKVEAAKTLVEGYSKIQ..GDIEDLMDFLQACKKYHLGKRFSYREYLISKIQSRDSHVSALINAAATQITSLINKTERAGHLPESHLGILLDRAEAEINFVKQKFDHDLK...................
H3C639_TETNG/239-664               ..........GSQVIVNYTAHIRSHKI-.--.DL...LDLPAFLTFSNASQNDVSMF...GPL..........TANLTLRVNSTDRIQPNHDAHFAGFVVGFFVTIVLLSLGFL.AINLTDSRTRLNIL..QQN...KKRRD........SDI..NNAD.CDLDESFKEE..AAFEDKIVDIMVLKRGFHCMNNSTSLE.....MSTLLRAT.....NNLEVTRIQIYKD..VMSLLLG.DLPSR.GHTSVQTQQRLLSVLDGQLLGMEGRLK.EERGARMTALANRCNLESREE.MEAEHHREAAEKAQAKLLCKQ.ADQQELLHCS.VLMEKLHKLKQSQLQDKLLVQHEEASAKVQRQIIEW........RRVELHKIFSEELEESTRMGEMERKTAESLQHEYFDCQ..DYLEEVLDMILANQRYVLAERHAQRKFLVHSLHSLNGLISDTFSITSDSLDNWFSQIKRGSTLPAEQVDQLQDKAQKELVMVRQRLDETM-s..................
G3WNX3_SARHA/141-568               ..........GDVYTVSYRARLTAKEAG.DG.KI...LSLPAQLTFQSPSLNKT---...-QL..........KALLTVRGQEKAKVSPNHGAHAAGFFIAFLVSLALTCIIFL.FMSQSRCFRWILCN..KNR...VEQSPh.....qeSKL..EYSQ.FTFVDGVSEE..FAISDQIIDILSAEEPGSMVQALEDME.....IATLTRAD.....ADLQACRMQISKD..IIGMLLK.NLTLS.GNLSPHMEKRMSSVFKKQFLMMETEVQ.EEYDRKMVALTAECTLEMRKK.TEAQCQREMAAMEEAEELLKH.VSERSALEYR.NLLHNLHRREQDHLRKSLLLKREEDFAKAYRELAIF........QRNELHNIFFTQIKSAVLKGDLKLETAKMLLQDYSKIQ..ENIEELMDFLQANKKYHLSKRFGYTQYLIQSIQSLGTRDQSLLNTATAQIMSLIHKNERAGYLDEDQMETLLARAQAEVLSVQQKLENDLK...................
F7AIR8_MOUSE/130-554               ..........GECYSVSYTASLDPTALG.TG.ES...LDLPARLIFQSPSQNRT---...-QL..........KAPFTITVEEKIMVLPNHGLHAAGFIAAFLISLLLTVAALF.FLARGRCLQGGMLS..RCR...IQHPE........NKL..EPSP.FTSANGVSQD..LSLNDQVVAILTSEEPGSMLQALEELE.....IATLNQAD.....ADLEACRNQISKD..IIALLMK.NLVSG.GHLSPQTERKMAAAFKKQFLLLENEIQ.EEYERKMLALTAECDLEMRKK.TENQYQREMVAMEEAEEVLKR.VSERSAAECS.SLLRTLHGLEQEDMQRSLTLDQAEDFAQAHRQLAVF........QRNELHSIVYTQIQSAVSKGELRPEVAKMMLQDYSKTQ..ESVEELMDFFQATKRYHLSKRFGHREYLVQRLQAMETRVQGLLNTAATQLTSLIHKHERAGYLDEDQMETLLERAQTETFSIKQKLDNDLK...................
G1P3L8_MYOLU/1-92                  ..........------------------.--.--...--------------------...---..........-----------------------------------------.--------------..---...-----........---..----.----------..---------------------------.....--------.....-------------..-------.-----.---------------------------.---------------------.---------------------.----------.------------------------------------........-------------------------------------Q..EEVEELMDFFQASKRYHLSKRFGHREYLVQNMQSAETRVQGLLSAAAAQLTLLIQKHERAGYLDEEQTEELMERAQTEVFSIKQKLDNDLK...................
Q4SBX0_TETNG/120-381               ........dr------------------.--.--...--------------------...---..........-----------------------------------------.--------------..---...-----........---..----.----------..---------------------------.....--------.....---------IYKD..VMSLLLG.DLPSR.GHTSVQTQQRLLSVLDGQLLGMEGRLK.EERGARMTALANRCNLESREE.MEAEHHREAAEKAQAKLLCKQ.ADQQELLHCS.VLMEKLHKLKQSQLQDKLLVQHEEASAKVQRQIIEW........RRVELHKIFSEELEESTRMGEMERKTAESLQHEYFDCQ..DYLEEVLDMILANQRYVLAERHAQRKFLVHSLHSLNGLISDTFSITSDSLDNWFSQIKRGSTLPAEQVDQLQDKAQKELVMVRQRLDETM-s..................
G1S1Y1_NOMLE/1-327                 .........k------------------.--.--...--------------------...---..........-----------------------------------------.--------------..---...VWQYE........SKL..EPLP.FTSADGVNED..LSLNDQMIDILSSEDPGSMLQALEELE.....IATLNRAD.....ADLEVCRTQISKD..VIALLLK.NLTSS.GHLSPQVERKMSAVFKKQFLLLENEIQ.EEYDRKMVALTAECDLETRKK.MENQYQREMMAMEEAEELLKR.ASERSAVECN.NLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVF........QRNELHSIFFTQIKSAIFKGELKPEAAKTLLQNYSKIQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLK...................
G1NJC2_MELGA/158-589               ..........GEYFAINYSALLDAKKTW.NG.RV...LTLPAQLTFRSLSQNQTDLV...-SL..........TTLFTITEEEKTEVSYSHAIHASGFFIAFFVSLVLTCAVFF.VLYRTQLLRWSFYS..KNQ...EIQHEls....qnHKL..EHSH.FNSGDLFSED..VIMNDQIIDILTFEESGNMLQALEDLE.....VASLTRAD.....ADLEAYRMQICKE..VIVMMMK.NMVLS.HSLIPHVEKRMSSVFKKQFLTMEREFQ.EEYERKVVALTAECNLETRKK.MEAQRQKERAANEEAEELMKK.VSEMPAVEYR.SLLDRLHSLEQDHLKRFLLVKQEEYFAKAYRQLTVS........QRKELHNIFFTEITNATFKGELKLEIAKSLVEDYSKIQ..GDIEELMDFLQASKKYHLNRRFAYREYLIRKIQLRDSQASALINAAATQILNLINKMERAGHLHESHLEMLLDRAEAEINSVKQKFDHDLK...................
F1LVK1_RAT/130-554                 ..........GECYSVSYMASLDPTALG.PG.ES...LDLPAQLIFQRPSQNRT---...-QL..........RARFTITVEEKIMVLPNHGLHTAGFIAAFLISFLLTLAALF.FLARGRCLQGSMLL..RCR...VQHPE........NKL..EPSP.FTSANGVSQD..LSLNDQLVAILTSEEPGSMLQALEELE.....IATLNQAD.....ADLEACRNQISKD..IIALLMK.NLISG.GHLSLQTERKMAAAFKKQFLLLENEIQ.EEYERKMLALTAECDLEVRKK.TENQYQREMVAMEEAEEVLKR.VSERSAAECS.SLLRTLHGLEQEDLQRSLTLQQAEDFAQAHRQLAVF........QRNELHSIVYTQIQSAVAKGELRPEVAKMLLQDYSKTQ..ESIEELMDFFQATKRYHLSKRFGHREYLVQRLQAMETRVQGLLSTAATQLTSLIHKHERAGYLDEDQMEMLLERAQTETFSIKQKLDNDLK...................
H3J3Q0_STRPU/383-828               ..........GETAVLSYNARLTQSLVDdNL.ET..dIQLESQLTWSSLPADEETNThpgTSFgp.....itdSICITQSITYEESLLYNHGLPALFFFVALILALVLVILCCF.IYAKMSAGGIYAIVqpEGT...ISKNQ........HGLiiNPRVgKTGVDMVEEYssVTANESIVVVLMQKDKTRKVLDFENLD.....IMSTITTD.....MRLEEQRISTMIE..MFIMLLG.SWSLR.DLLPRDFSAKLSKKYQRSAKDAIKKLD.DEYGHESRELIKHLSNENKGK.LIMLKKKHDAELRLKAAQARS.LSKEDLKEVM.DLLKKQQAAGATSLTQLLRLKQDEEQEKLRKEYATK........KRIAMKAVQQEYMDKAILQGKLDEDQARRLLSEHQQDM..STVERLMDEEMSRQRMSLEEKLARRKLLAKATESQEEHHSALLNTMASQTMTAVSELEQSEQLGQEEAKAYVEKLMKEVKGIKENYEKER-r..................
E6ZG52_DICLA/142-567               ..........GSQVIVNYTAHIRSHKN-.--.EV...LDLPAFLTFSNASQNDVSMF...GPL..........TANLTLRVNSTDRIYPNHGVHFAGFVVGFFVTLVLLSLGFL.AMNLIGPRTRLNLL..QQR...RNRGD........SDP..EYTD.CNMTETVKDE..ATFEDKMVDTMVLEDPQNMYQALENLE.....MSTLLHAT.....NNLEATRIQIYKD..VMSSLLS.GLRSR.GQASAQAQQRLLSVLHGQLLGMEGRLK.EERGARMAALAGRCNLETREE.MEAEHCREAAEKTQAELLCQH.ADQQELLHCS.VLLEKLHKLSQSQLQRMLLVRHEEASAKVQRQIIEW........RRVELHKIFSEELEEATRMGELEKSTAKSLQHYYFACQ..DQLEEVLDVVVANQRYVIAERHAQRKFLVHSLHSLNSLISDTFSSTSSNLDSWFTHIRRGSIVPEEQIDQLQEKAQKELVMVRQRLDEAL-s..................
D3ZWT7_RAT/148-572                 ..........GECYSVSYMASLDPTALG.PG.ES...LDLPAQLIFQRPSQNRT---...-QL..........RARFTITVEEKIMVLPNHGLHTAGFIAAFLISFLLTLAALF.FLARGRCLQGSMLL..RCR...VQHPE........NKL..EPSP.FTSANGVSQD..LSLNDQLVAILTSEEPGSMLQALEELE.....IATLNQAD.....ADLEACRNQISKD..IIALLMK.NLISG.GHLSLQTERKMAAAFKKQFLLLENEIQ.EEYERKMLALTAECDLEVRKK.TENQYQREMVAMEEAEEVLKR.VSERSAAECS.SLLRTLHGLEQEDLQRSLTLQQAEDFAQAHRQLAVF........QRNELHSIVYTQIQSAVAKGELRPEVAKMLLQDYSKTQ..ESIEELMDFFQATKRYHLSKRFGHREYLVQRLQAMETRVQGLLSTAATQLTSLIHKHERAGYLDEDQMEMLLERAQTETFSIKQKLDNDLK...................
Q4SBX0_TETNG/67-123                ..........GSQVIVNYTAHIRSHKI-.--.DL...LDLPAFLTFSNASQNDVSMF...GPL..........TANLTLRVNSTDRI---------------------------.--------------..---...-----........---..----.----------..---------------------------.....--------.....-------------..-------.-----.---------------------------.---------------------.---------------------.----------.------------------------------------........--------------------------------------..-------------------------------------------------------------------------------------------y..................
G3RCY4_GORGO/190-614               ..........GDAFAVSYAATLQAGDLG.NG.ES...LKLPAQLTFQSSSRNRT---...-QL..........KALFSITAEENITVLPHHSLHAAGFFIAFLLSLVLTWAALF.LMVRYQCLKGNMLT..RHR...VWQYE........SKL..EPLP.FTSADGVNED..LSLNDQMIDILSSEDPGSMLQALEELE.....IATLNRAD.....ADLEACRTQISKD..IIALLLK.NLTSS.GHLSLQVERKMSAVFKKQFLLLENEIQ.EEYDRKMVALTAECDLETRKK.MENQYQREMMAMEEAEELLKR.ASERSAVECS.NLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVF........QRNELRSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLK...................
LBN_HUMAN/237-661                  ..........GDAFAVSYAATLQAGDLG.NG.ES...LKLPAQLTFQSSSRNRT---...-QL..........KVLFSITAEENVTVLPHHGLHAAGFFIAFLLSLVLTWAALF.LMVRYQCLKGNMLT..RHR...VWQYE........SKL..EPLP.FTSADGVNED..LSLNDQMIDILSSEDPGSMLQALEELE.....IATLNRAD.....ADLEACRTQISKD..IIALLLK.NLTSS.GHLSPQVERKMSAVFKKQFLLLENEIQ.EEYDRKMVALTAECDLETRKK.MENQYQREMMAMEEAEELLKR.AGERSAVECS.NLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVF........QRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLK...................
E9PFT2_HUMAN/157-413               ..........GDAFAVSYAATLQAGDLG.NG.ES...LKLPAQLTFQSSSRNRT---...-QL..........KVLFSITAEENVTVLPHHGLHAAGFFIAFLLSLVLTWAALF.LMVRYQCLKGNMLT..RHR...VWQYE........SKL..EPLP.FTSADGVNED..LSLNDQMIDILSSEDPGSMLQALEELE.....IATLNRAD.....ADLEACRTQISKD..IIALLLK.NLTSS.GHLSPQVERKMSAVFKKQFLLLENEIQ.EEYDRKMVALTAECDLETRKK.MENQYQREMMAMEEAEELLKR.A---------.------------------------------------........--------------------------------------..-------------------------------------------------------------------------------------------vccrvq.............
LBN_BOVIN/137-561                  ..........GDSFSVSYTASLEARDVG.SG.DI...LLLPAQLSFQSSSPNRT---...-QL..........KAPFTITAEEKITVLPNHGLHAAGFCVAFILSLVLTWAVLF.FMVRYQCVKGSSLT..RHQ...VQHHE........NKL..EHSQ.FTSADGVNED..LALNDQMIDILSSEDPGSMLQALEELE.....IATLNRAD.....SDLEACRTQISKD..IIALLLK.NLTSS.GQLSPQVERRMGAVFKKQFLLLEKEIQ.EEYDRKMVALTAECDLETRKK.TESQYQREMAAMEEAEEVLKR.VSERSAVECS.SLLRTLHGLEQEHLRRSLALQQEEDLAKAHRQLAIF........QRNELHNIFFTQIKSAIFKGELKPEAAKMLLQDYSKIQ..ESVEELMDFFQASKRYHLSKRFGHREYLVQNIQSSETRMQGLLSTASAQLTLLIQKHERAGYLDEDQMQVLLERAQTEVFSIKQKLDNDLK...................
H0VEZ5_CAVPO/234-660               ..........GDSYLVSYTASLDPGAIS.TL.ES...LSLPAQLTFQSSMLNRT---...-QL..........QAVLTITVAEKITVLPHHGLHAAGFFIGFLLSLVLSWVALF.LLVHYRCLPGGLLA..GHS...ALYAE........NKL..EPSP.FASADGISED..LSLNDQMIDILTSEDPRSMLQALEELE.....IATLNRAD.....ADLEACRTQISKD..IIGFLLR.SLTCG.GHLSPQVERRDRFCFEKSSFLLAGKMEvQTFDRQLFTLACGWAVENRVKgQKSEYKNKKLKMAEKDDMASW.GAEQSAAECS.SLLRTLHGLEQEHVWKSLALHQEEDFAQAHRQLAVF........QRTELHGIFFAQIKNAIFKGELKPEAAKTLLQDYSKLQ..EHMEELMDFFQATKRYHLSKRFGHREYLVQNLQSTETRVQGILNTAATQLTHLIQKHERAGYLDEDQMEMLLERVQMEVFSVKQKLDNDLK...................
G1TBK9_RABIT/233-659               ..........GDSYWVSYTASMDARALG.TG.NS...LTLPAQLTFRSWSLNSS---...-QL..........KAHFTITVEEKVTVLPNHGLHAAAFFGAFVMSFLLSWAVLF.WAARCWCLKGGACT..RTG...VQRHG........SKL..EPPL.FSSASGVSED..LALSDQLVDILASEDPGGMLQALEDLY.....VSFIRRGR.....IPVPQCRTGHPSSamSISLSIS.NLSGSgGHVLPGV-AILAAFCPGTLLALGNTIK.RAWDHAFVCLKAHFNLERNAQ.LLTTFQISNAALNHAECSFSQ.REDQAAAECA.GLLRSLHGLEQEHLQASLALQREEDFAEAHRQLAVL........RRNELHSVFFSQIRSAVCEGDLKPEAAKELLQDYSKVQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSTETRVQGLLSAAAAQLTHLIQKHERAGYLEEDQTELLLERAHTEVFAVQQRLDHDLK...................
H2QP60_PANTR/237-661               ..........GDAFAVSYAATLQAGDLG.NG.ES...LKLPAQLTFQSSSRNRT---...-QL..........KALFSITAEENITVLPHHGLHAAGFFIAFLLSLVLTWAALF.LMVRYQCLKGNMLT..RHR...VWQYE........SKL..EPLP.FTSADGVNED..LSLNDQMIDILSSEDPGSMLQALEELE.....IATLNRAD.....ADLEACRTQISKD..IIALLLK.SLTSS.GHLSPQVERKMSAVFKKQFLLLESEIQ.EEYDRKMVALTAECDLETRKK.MENQYQREMMAMEEAEELLKR.ASERSAVECS.NLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVF........QRNELHSIFFTQIKSAIFKGELKPEAAKTLLQNYSKIQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEVLLERAQTEVFSIKQKLDNDLK...................
F7HNC8_MACMU/157-581               ..........GDAFAVSYAATLQAGDLG.NG.ES...LKLPAQLTFQSSSQNRT---...-QL..........KALFSITAEESITVLPHHGLHAAGFFIAFLLSLVLTWAALF.LMVHYQCLKGSMLT..RHR...VWQYD........SKL..EPLP.FTSADGVNED..LSLNDQMIDILSSEDPGSMLQALEELE.....IATLNRAD.....ADLEACRTQISKD..IIALLLK.NLTSS.GHLSPQVERKMSDVFKKQFMLLENEIQ.EEYDRKMVALTAECDLETRKK.MENQYQREMMAMEEAEELLKR.ASERSAVECN.SLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVF........QRNELHRIFFTQIKSAILKGELKPEAAKTLLQNYSKIQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLK...................
F6R759_CALJA/501-607               spmfkrvlli------------------.--.--...--------------------...---..........-----------------------------------------.--------------..---...-----........---..----.----------..---------------------------.....--------.....-------------..-------.-----.---------------------------.---------------------.---------------------.----------.------------------------------------........--------------------------------LYWRLK..ENVEELMDFFQANKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEVLLERAQTEVFSIKQKLDNDLK...................
G7MSJ3_MACMU/208-632               ..........GDAFAVSYAATLQAGDLG.NG.ES...LKLPAQLTFQSSSQNRT---...-QL..........KALFSITAEESITVLPHHGLHAAGFFIAFLLSLVLTWAALF.LMVHYQCLKGSMLT..RHQ...VWQYD........SKL..EPLP.FTSADGVNED..LSLNDQMIDILSSEDPGSMLQALEELE.....IATLNRAD.....ADLEACRTQISKD..IIALLLK.NLTSS.GHLSPQVERKMSDVFKKQFMLLENEIQ.EEYDRKMVALTAECDLETRKK.MENQYQREMMALEEAEELLKR.ASERSAVECN.SLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVF........QRNELHRIFFTQIKSAILKGELKPEAAKTLLQNYSKIQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLK...................
C3Y3M0_BRAFL/480-919               ..........GEELLLSFQAEMECKERE.CA.ESspnLTIPANVTYRSVAVQQAANS...TQFqgidygplmdSICLGFDLVELTSLFRNYGYIGLALVVFLLVGIVVGLLCCF.LLGRTRGMQVRPL-..RGR...SKKKKgg....lfSGL..KNRL.KGLGSWFGEL..-----NFASILTFRDISKMFRWLDNLD.....IKSSIDLD.....IKLQGHRLQLMIN..SINIQLQ.KLRHK.GEISRPILDRVQDKFNKAWRALCRRLG.EEYQKALSRLHKRLAAKNKDN.VDSLHKKHEEERKQLIDRTTN.TPEKERRELV.KLLDQQHQVETEELSYRLQLEQAEEEEKIRKEFELK........KRVGLKELQHNLLKDLAEQAELSEEEAARIMREHKENQ..ATINRLMDEEMSRQRMLLEEKLAQRRAMAKAKEHQEDHNKKVLNTLATQQAGIVQEMREDGKLSAEQEQMFKERIRREMLAARERHDKSRE...................
E1BES3_BOVIN/137-563               ..........GDSFSVSYTASLEARDVG.SG.DI...LLLPAQLSFQSSSPSRT---...-LH..........AYPLVVTCLERCEVLPNHGLHAAGFCVAFILSLVLTWAVLF.FMVRYQCVKGSSLT..RHQ...VQHHE........NKL..EHSQ.FTSADGVNED..LALNDQMIDILSSEDPGSMLQALEELE.....IATLNRAD.....SDLEACRTQISKD..IIALLLK.NLTSS.GQLSPQVERRMGAVFKKQFLLLEKEIQ.EEYDRKMVALTAECDLETRKK.TESQYQREMAAMEEAEEVLKR.VSERSAVECS.SLLRTLHGLEQEHLRRSLALQQEEDLAKAHRQLAIF........QRNELHNIFFTQIKSAIFKGELKPEAAKMLLQDYSKIQkqESVEELMDFFQASKRYHLSKRFGHREYLVQNIQSSETRMQGLLSTASAQLTLLIQKHERAGYLDEDQMQVLLERAQTEVFSIKQKLDNDLK...................
Q5QGM3_CHICK/231-662               ..........GEYFAINYTALLDAKKTW.KG.RV...LTLPAQLTFRSSSQNQTDLV...-SL..........TTLFTITEEEKTEVSYSHAIHASGFFIAFFVSLVLTCAVFF.ILYRTQLLRWSFYS..ENQ...EIQHEls....qnHKL..EHSQ.FSSGDLFSED..VIMNDQIIDILTFEESGNMLQALEDLE.....VASLTRAD.....ADLEAYRMQICKE..VIAIMMK.NMVLS.HSLIPHVEKRMSSIFKKQFLTMEREFQ.EEYERKVVALTAECNLETRKK.MEAQRQKERAANEEAEELIRK.VNEMPAVEYK.SLLDRLHSLEQDHLKRFLLVKQEEYFAKAYRQLAVS........QRKELHNIFFTQITNATFKGELKLEIAKSLVEDYSKIQ..GDIEELMDFLQASKKYHLNRRFAYREYLIKKIQLRDSQASALINAAATQILNLINKMERAGHLHESHLGMLLDRAEAEINSVKQKFNHDLK...................
#=GC seq_cons                      ..........G-tasVsYsApLputclh.sG.Es...LpLPApLTFpSsSpNco.......pL..........pAhholsspEphpVhPsHGlHuAGFhlAFllSlVLThsshF.hhs+hpslptshls..cpp...h.p.-........sKL..E....FsSu-uVsED..luhsDQhlDILo.E-PGsMlQALE-LE.....lATLsRAD.....ucLEAsRhQIsKD..lIulLLK.sLsSs.GHLSsQsE++huulFKKQFLhhEsElQ.EEY-RKMlALTAECsLEoRKK.hEsQaQREhsAhEEAEELhK+.suEcsAhECs.sLLcpLHtLEQ-cLp+pLhlppEEshAKApRQLAla........pRsELHpIFasQlcsAlhpGEL+.EsAKhLlpcYuchQ..-slEELMDFhQAsKRYHLu+RFuaREYLVpslQS.-o+lpuLLSoAusQLspLIpKpERAGaLcE-Qh-hLLERAQsElhSlKQKLDpDLK...................
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