GenomeNet

Database: Pfam
Entry: EVC2_like
LinkDB: EVC2_like
Original site: EVC2_like 
#=GF ID   EVC2_like
#=GF AC   PF12297.6
#=GF DE   Ellis van Creveld protein 2 like protein
#=GF AU   Assefa S, Gavin OL
#=GF SE   PFAM-B_3668 (release 23.0)
#=GF GA   25.00 25.00;
#=GF TC   25.20 25.80;
#=GF NC   24.30 24.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12468274
#=GF RT   A new gene, EVC2, is mutated in Ellis-van Creveld syndrome.
#=GF RA   Galdzicka M, Patnala S, Hirshman MG, Cai JF, Nitowsky H, Egeland
#=GF RA   JA, Ginns EI;
#=GF RL   Mol Genet Metab. 2002;77:291-295.
#=GF DR   INTERPRO; IPR022076;
#=GF CC   This family of proteins is found in eukaryotes. Proteins in this
#=GF CC   family are typically between 571 and 1310 amino acids in length.
#=GF CC   There are two conserved sequence motifs: LPA and ELH. EVC2 is
#=GF CC   implicated in Ellis van Creveld chondrodysplastic dwarfism in
#=GF CC   humans. Mutations in this protein can give rise to this
#=GF CC   congenital condition. LIMBIN is a protein which shares around
#=GF CC   80% sequence homology with EVC2 and it is implicated in a
#=GF CC   similar condition in bovine chondrodysplastic dwarfism.
#=GF SQ   77
#=GS H2UVR7_TAKRU/110-531      AC H2UVR7.1
#=GS W5MV69_LEPOC/196-622      AC W5MV69.1
#=GS G3RCY4_GORGO/190-613      AC G3RCY4.1
#=GS A7SYD8_NEMVE/92-366       AC A7SYD8.1
#=GS W4YQQ3_STRPU/385-634      AC W4YQQ3.1
#=GS F6Y9V1_HORSE/162-585      AC F6Y9V1.1
#=GS G1TBK9_RABIT/233-658      AC G1TBK9.1
#=GS L5K473_PTEAL/97-493       AC L5K473.1
#=GS K1PHU8_CRAGI/515-659      AC K1PHU8.1
#=GS W4YZ64_STRPU/383-827      AC W4YZ64.1
#=GS G7P586_MACFA/161-584      AC G7P586.1
#=GS L8YDQ5_TUPCH/90-497       AC L8YDQ5.1
#=GS W4YQQ3_STRPU/630-765      AC W4YQQ3.1
#=GS S9WQI5_9CETA/77-232       AC S9WQI5.1
#=GS LBN_BOVIN/137-560         AC Q8MI28.1
#=GS A0A0D9RUG0_CHLSB/237-660  AC A0A0D9RUG0.1
#=GS M7BBC7_CHEMY/89-431       AC M7BBC7.1
#=GS F1PZ45_CANLF/274-697      AC F1PZ45.2
#=GS H3D093_TETNG/239-663      AC H3D093.1
#=GS H2PCV7_PONAB/237-660      AC H2PCV7.1
#=GS G1S1Y1_NOMLE/1-326        AC G1S1Y1.1
#=GS H0WGP0_OTOGA/125-548      AC H0WGP0.1
#=GS G3SZ90_LOXAF/87-510       AC G3SZ90.1
#=GS L5LNW7_MYODS/91-514       AC L5LNW7.1
#=GS C3Y3M0_BRAFL/480-918      AC C3Y3M0.1
#=GS G3P033_GASAC/53-475       AC G3P033.1
#=GS F6T7X1_XENTR/123-549      AC F6T7X1.1
#=GS F6R759_CALJA/231-496      AC F6R759.1
#=GS F6XGD8_MONDO/65-491       AC F6XGD8.2
#=GS M3ZBJ7_NOMLE/157-215      AC M3ZBJ7.1
#=GS A0A0P7UEV3_9TELE/248-355  AC A0A0P7UEV3.1
#=GS G1NJC2_MELGA/158-588      AC G1NJC2.2
#=GS I3L853_PIG/64-480         AC I3L853.1
#=GS U3K4E6_FICAL/169-599      AC U3K4E6.1
#=GS F7HNC8_MACMU/157-580      AC F7HNC8.1
#=GS F6R759_CALJA/504-606      AC F6R759.1
#=GS M3Y955_MUSPF/228-651      AC M3Y955.1
#=GS G3P019_GASAC/136-555      AC G3P019.1
#=GS H2UVR6_TAKRU/110-534      AC H2UVR6.1
#=GS I3MBP0_ICTTR/237-660      AC I3MBP0.1
#=GS H3C639_TETNG/239-663      AC H3C639.1
#=GS A0A096NZD3_PAPAN/237-660  AC A0A096NZD3.1
#=GS LBN_MOUSE/147-570         AC Q8K1G2.1
#=GS W5MV80_LEPOC/212-638      AC W5MV80.1
#=GS V3YXV9_LOTGI/182-290      AC V3YXV9.1
#=GS M4AVJ8_XIPMA/238-662      AC M4AVJ8.1
#=GS A0A091D6A2_FUKDA/157-580  AC A0A091D6A2.1
#=GS W5PAS6_SHEEP/228-651      AC W5PAS6.1
#=GS M3W1I7_FELCA/228-651      AC M3W1I7.1
#=GS G5B315_HETGA/155-578      AC G5B315.1
#=GS LBN_HUMAN/237-660         AC Q86UK5.1
#=GS L7N188_MYOLU/1-96         AC L7N188.1
#=GS H2QP60_PANTR/237-660      AC H2QP60.1
#=GS E1BES3_BOVIN/137-562      AC E1BES3.2
#=GS F1NTF8_CHICK/231-661      AC F1NTF8.2
#=GS H2UVR5_TAKRU/110-534      AC H2UVR5.1
#=GS H2MQ97_ORYLA/136-560      AC H2MQ97.1
#=GS A0A087XL09_POEFO/242-666  AC A0A087XL09.2
#=GS A0A0C4DGE7_HUMAN/157-580  AC A0A0C4DGE7.1
#=GS F7HNC9_MACMU/237-660      AC F7HNC9.1
#=GS G1LXD6_AILME/162-585      AC G1LXD6.1
#=GS K1PHU8_CRAGI/212-475      AC K1PHU8.1
#=GS G3WNX3_SARHA/141-567      AC G3WNX3.1
#=GS G3SIS4_GORGO/191-615      AC G3SIS4.1
#=GS H0ZI81_TAEGU/123-548      AC H0ZI81.1
#=GS H0VEZ5_CAVPO/234-659      AC H0VEZ5.1
#=GS F7HND1_MACMU/157-580      AC F7HND1.1
#=GS D3ZWN3_RAT/147-570        AC D3ZWN3.1
#=GS V3YXV9_LOTGI/367-670      AC V3YXV9.1
#=GS I3NCM7_ICTTR/149-572      AC I3NCM7.1
#=GS S9WQI5_9CETA/292-573      AC S9WQI5.1
#=GS C3Y3M0_BRAFL/1064-1427    AC C3Y3M0.1
#=GS U3I932_ANAPL/129-558      AC U3I932.1
#=GS E9PFT2_HUMAN/157-413      AC E9PFT2.1
#=GS I3KTK1_ORENI/242-666      AC I3KTK1.1
#=GS G3WNX4_SARHA/65-491       AC G3WNX4.1
#=GS G1P3L8_MYOLU/1-91         AC G1P3L8.1
H2UVR7_TAKRU/110-531                 ............................GSQVIVNYTAQIRSH..---KIEV...LDLPAFLTFS........NASQ.NDVSMFGPLTTNLTLR--..----IHPNHSAHFAGFVVGFF..VTIVLLSLGFLAM.NLTGSRTRLNLLQQC.KYpRKREDSDP.DD.ADCNIDETIKEEAA.........FEDKIVDTMVLEEPQNMYQSLEN.LE......MSTLL..RAT..NNMEATRIQIYKDV..MSSLLG.GLLSQGHASMQTQQRLLSVLYGQLLGMEGRLK.EERAARMAALANQCNLESR.EEMEAEHHRETAEKAQAELLYKQ.ADQQELLRCSVLLEKLHKLRQSRLQAKLLVQHEEASAKVQRQIIEW........RRVELHKIFSEELEEATRMGEMERSTAKSLQHEYFDCQ..DHLEEVLDVVLANQRYVLAERHAQRKFLVHSLHSLNSLISDTFSITSNNLDNWFCQIR..RGSTLPVEKVDQLQDEAQKELVMVRQRLDEAL................
W5MV69_LEPOC/196-622                 ............................GSCYTVKYSAQMKGE..---QNDI...LSLPAYLTFS........NASQ.NDINLFGPVVANFTLRVN..STAKVSSNHGIHFVGFLVGFL..VASILMTLAFLLF.SWIGIPQMSCCKRKR.RG.GLSGDTDP.EY.AVCNVSETAKEEAA.........FEDKIVDIMILEDPQNMYQALEN.LD......MSTLL..RAA..ASLESFRVQVYKDL..VAMLLR.NLKMNGGVSALAEKRLNSVLNGQLMGMEGKLK.EEHVARMAALAAECNRETR.EEMEAEHRRVTVEKAQAEHLFQQ.ADQQVVLELSVLLDKLHKLDQSYLQRCLLVRHEEASAKVQRQTVVC........RRLELHKIFFEELEEATRMKELEKNVANQLLHAYFSSQ..DQLEEVLDIFLANQRSILEERHAQRQFLAHSLQSLKTLICEVFTNTSRQMENWFQDLK..NERYVTEEQANLLLDKAKKELLHVKQNLDEGL................
G3RCY4_GORGO/190-613                 ............................GDAFAVSYAATLQAG..DLGNGES...LKLPAQLTFQ........-SSS.RNRTQLK---ALFSITAE..ENITVLPHHSLHAAGFFIAFL..LSLVLTWAALFLM.VRYQCLKGNMLTRHR.VW.--QYESKL.EP.LPFTSADGVNEDLS.........LNDQMIDILSSEDPGSMLQALEE.LE......IATLN..RAD..ADLEACRTQISKDI..IALLLK.NLTSSGHLSLQVERKMSAVFKKQFLLLENEIQ.EEYDRKMVALTAECDLETR.KKMENQYQREMMAMEEAEELLKR.ASERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVF........QRNELRSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHE..RAGYLDEDQMEMLLERAQTEVFSIKQKLDNDL................
A7SYD8_NEMVE/92-366                  .....................edvemer---------------..-------...----------........----.------------------..---------------------..-------------.---------------.--.--------.--.--------------.........-----------------------.--......-----..---..----------LRKV..MGLLAK.KLRVKRDISTSQEKNFIAKLKSEIAGVSQRLG.ADFKRRSAEVRRKIQRMLK.AAHADMVRRQAKEIKETEAKIKGlVSQRERRDIIDVLRRRHAKEEEDLRKKFKLEEDVEMERLRKKAKFFyptgscsyKRFTMKEAQSKLLQDLIKEAEFNEDQASALVKEHLGNM..AAVDKAMDEEKSRRVVALEMRLAERRALAIQKHDESDFNKRLVQSLEEQHENTMQSLV..SSSKISEAEANAYIERYKKEVDALKEKTEKE-kr..............
W4YQQ3_STRPU/385-634                 ............................GETAVLSYNARLTQS..SVDDNLEt.dIQLESQLTWSslpadeetNTHP.--GTSFGPITDSICITQAitYEESLLYNHGLPALFFFVALI..LALVLVILCCFIY.AKMSAGGIYAIVQPEgTIsKNQHGLII.NP.RVGKTGVDMVEEYSs......vtANESIVVVLMQKDKTRKVLDFEN.LD......IMSTI..TTD..MRLEEQRNSTMIEM..FIMLLG.SWALRDLLPRDFSAKLSKKYQRSAKDAIKKLD.DEYGHKSRELIKHLSNENK.E----------------------.----------------------------------------------........--------------------------------------..----------------------------------------------------------..--------------------------------y...............
F6Y9V1_HORSE/162-585                 ............................GDSFSVNYTASLEAR..DVGSGEI...LMLPARLTFQ........-SSS.PNRTQLK---ALFTIIAE..EKIKILPDHGLHAAGFFTAFI..GSLVLTWVALFFL.VRCECLRGSRLGRRQ.VQ.--HHESRL.EH.SQFISADGVNEDLA.........LNDQMVDILSSEDPGSMLQALEE.LE......IATLN..RAD..SDLEACRTQISKDI..IALLLK.NLTSSGHLSPQAERRMAAVFKKQFLLLEKEIQ.EEYDRKMVALTAECDLETR.KKTENQYQREMAAMEEAEELLKR.VSERSAVECSDLLRALHGLEQEQLRRSLALQQEEDVAKAHRQLAIF........QRNELHSIFFTQIKSAIFKGELKPEAAKMLLQDYSKIQ..ENVEELMDFFQASKRYHLSKRFGHRECLVQNMQSSETRVQGLLSAAAAQLSLLIQKHE..RAGYLEEHQMEVLLERAQTEVFSIKQKLDNDL................
G1TBK9_RABIT/233-658                 ............................GDSYWVSYTASMDAR..ALGTGNS...LTLPAQLTFR........-SWS.LNSSQLK---AHFTITVE..EKVTVLPNHGLHAAAFFGAFV..MSFLLSWAVLFWA.ARCWCLKGGACTRTG.VQ.--RHGSKL.EP.PLFSSASGVSEDLA.........LSDQLVDILASEDPGGMLQALED.LY......VSFIR..RGR..IPVPQCRTGHPSSAmsISLSIS.NLSGSGGHVLPGVAILAAFCPGTLLALGNTIK.RAWDHAFVCLKAHFNLERN.AQLLTTFQISNAALNHAECSFSQ.REDQAAAECAGLLRSLHGLEQEHLQASLALQREEDFAEAHRQLAVL........RRNELHSVFFSQIRSAVCEGDLKPEAAKELLQDYSKVQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSTETRVQGLLSAAAAQLTHLIQKHE..RAGYLEEDQTELLLERAHTEVFAVQQRLDHDL................
L5K473_PTEAL/97-493                  ...................rssseptgl---------------..-------...----------........----.RNRTQLK---ALFTVTAE..EKIKVLPNHGLHVAGFFVAFI..VSLVLAWVTLSIM.GRYQCWKGSVLTGHQ.VQ.--HHESKL.EH.SQCTSADGVNEDLA.........LNDHMVDILFSEDPGGMLQALEE.LE......IATLN..RAD..AELEACRTQISKDV..IALLLS.NLASSGHLSTQVERRMGAVFKKQFLXXXXX-X.XXXXRKMVALTAECDLETR.KKTENQYQREVAATEEAEELLKR.VSERSAAECSASLRALHGLELGHLRRSLALQKEEDFARARRQLAVF........QRSELHNIFFAQIKSAIFKGELKPEAAKMLLQDYCNIQ..EDVEELMDYFQASKRYHLSKRFGHREYLVQNIQSSETRVQGLLSAAAAQLTLLIQKHE..RAGYLDEGQMEVLLERAQTEVFSVKQKLDSDL................
K1PHU8_CRAGI/515-659                 ...................gkqfrsisf---------------..-------...----------........----.------------------..---------------------..-------------.---------------.--.--------.--.--------------.........-----------------------.--......-----..---..--------------..------.--------------------------------.-------------------.-----------------------.----------------------------------------QEFAVR........RRMGMKELQQDQLEEVMTQGHLVGEKADWLLEEHRKVQ..AQMEKMYDEEVARQRILLEEKLEKRKALAKLEEQQEDDGSDVLNTMASHQIELINKAKakKVGGLTPDEASELIAKAKEDMISLKERLDKDR................
W4YZ64_STRPU/383-827                 ............................GETAVLSYNARLTQS..LVDDNLEt.dIQLESQLTWSslpadeetNTHP.--GTSFGPITDSICITQSitYEESLLYNHGLPALFFFVALI..LALVLVILCCFIY.AKMSAGGIYAIVQPEgTIsKNQHGLII.NP.RVGKTGVDMVEEYSs......vtANESIVVVLMQKDKTRKVLDFEN.LD......IMSTI..TTD..MRLEEQRISTMIEM..FIMLLG.SWSLRDLLPRDFSAKLSKKYQRSAKDAIKKLD.DEYGHESRELIKHLSNENK.GKLIMLKKKHDAELRLKAAQARS.LSKEDLKEVMDLLKKQQAAGATSLTQLLRLKQDEEQEKLRKEYATK........KRIAMKAVQQEYMDKAILQGKLDEDQARRLLSEHQQDM..STVERLMDEEMSRQRMSLEEKLARRKLLAKATESQEEHHSALLNTMASQTMTAVSELE..QSEQLGQEEAKAYVEKLMKEVKGIKENYEKER................
G7P586_MACFA/161-584                 ............................GDAFAVSYAATLQAG..DLGNGES...LKLPAQLTFQ........-SSS.QNRTQLK---ALFSITAE..ESITVLPHHGLHAAGFFIAFL..LSLVLTWAALFLM.VHYQCLKGSMLTRHR.VW.--QYDSKL.EP.LPFTSADGVNEDLS.........LNDQMIDILSSEDPGSMLQALEE.LE......IATLN..RAD..ADLEACRTQISKDI..IALLLK.NLTSSGHLSPQVERKMSDVFKKQFMLLENEIQ.EEYDRKMVALTAECDLETR.KKMENQYQREMMAMEEAEELLKR.ASERSAVECNSLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVF........QRNELHRIFFTQIKSAILKGELKPEAAKTLLQNYSKIQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHE..RAGYLDEDQMEMLLERAQTEVFSIKQKLDNDL................
L8YDQ5_TUPCH/90-497                  ............................GDFYLVSYTASLQTRdgDIRNGDS...LMLPAQLTFQ........-S--.-----LS-----------..---LVLPDHGLHAAGFFTAFL..LSLMLTWLVLFFM.VRCQCLQGYMLTRCG.VR.--PHESKL.EP.SPFTSADGVNEDLS.........LNDQMIEILSSEDPGSMLQALEE.LE......IATLN..RAD..ADLEACRMQISKDI..IVLLLK.NLTSNGHLSPQAERRLGSVFKKQFLLLENEIQ.EEYDRKMLALTAECDLETR.KKTENQYQREMVAMEEMEELLKR.VSERSAVECSNLLRTLHGLELEHLRRSLALQREEDFAKAHRQLAVF........QRNELHNIFFTQIRSAIFKGELKPEAAKMVLQNYSEIQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLNAAAAQLTLLIQKHE..RAGYLDEDQMQVLLERAQTEVFSVKQKLDNDL................
W4YQQ3_STRPU/630-765                 ..........................en---------------..-------...----------........----.------------------..---------------------..-------------.---------------.--.--------.--.--------------.........-----------------------.--......-----..---..--------------..------.--------------------------------.-------------------.-----------------------.----------------------------------------KEYATK........KRIAMKAVQQEYMDKAILQGKLDEDQARRLLSEHQQDM..STVERLMDEEMSRQRMSLEEKLARRKLLAKATESQEEHHSALLNTMASQTMTAVSDLE..QSEQLGQEEAKAYVEKLMKEVKGIKENYEKER................
S9WQI5_9CETA/77-232                  ............................GDSFSVSYTALLEVE..DVKGGEV...LMLPARLSFQ........-TSS.PNRIQLE---ALFTITTE..--EKVLPNHGLHAAGFFVAFI..LSLLLTWTALFFM.VRYRCLKGSLLTRHQ.--.GQHHESKL.EH.SQFT-ADGVNEDLA.........LNDQMVDILSSEDPGSMLQALEE.--......-----..---..--------------..------.--------------------------------.-------------------.-----------------------.----------------------------------------------........--------------------------------------..----------------------------------------------------------..--------------------------------flggsssprapng...
LBN_BOVIN/137-560                    ............................GDSFSVSYTASLEAR..DVGSGDI...LLLPAQLSFQ........-SSS.PNRTQLK---APFTITAE..EKITVLPNHGLHAAGFCVAFI..LSLVLTWAVLFFM.VRYQCVKGSSLTRHQ.VQ.--HHENKL.EH.SQFTSADGVNEDLA.........LNDQMIDILSSEDPGSMLQALEE.LE......IATLN..RAD..SDLEACRTQISKDI..IALLLK.NLTSSGQLSPQVERRMGAVFKKQFLLLEKEIQ.EEYDRKMVALTAECDLETR.KKTESQYQREMAAMEEAEEVLKR.VSERSAVECSSLLRTLHGLEQEHLRRSLALQQEEDLAKAHRQLAIF........QRNELHNIFFTQIKSAIFKGELKPEAAKMLLQDYSKIQ..ESVEELMDFFQASKRYHLSKRFGHREYLVQNIQSSETRMQGLLSTASAQLTLLIQKHE..RAGYLDEDQMQVLLERAQTEVFSIKQKLDNDL................
A0A0D9RUG0_CHLSB/237-660             ............................GDAFAVSYAATLQAG..DLGNRES...LKLPAQLTFQ........-SSS.QNRTQLK---ALFSITAE..ESITVLPHHGLHAAGFFIAFL..LSLVLTWAALFLM.VHYQCLKGSVLTRQR.VW.--QYDSKL.EP.LPFTSADGVNEDLS.........LNDQMIDILSSEDPGSMLQALEE.LE......IATLN..QAD..ADLEACRTQISKDI..IALLLK.NLTSSGHLSPQVERKMSDVFKKQFMLLENEIQ.EEYDRKMVALTAECDLETR.KKMENQYQREMMAMEEAEELLKR.ASERSAVECNSLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVF........QRNELHRIFFTQIKSAILKGELKPEAAKTLLQNYSKIQ..ENIEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHE..RAGYLDEDQMEMLLERAQTEVFSIKQKLDNDL................
M7BBC7_CHEMY/89-431                  .........ltasftitgeektkeiryd---------------..-------...----------........----.------------------..---------------------..-------------.---------------.--.-PTLDRKL.EY.SQLNSGDPFNEDII.........MNDQIIEILAFEDSGNMLQALED.LE......VANLT..RAD..ADLEAYRMQMCKEA..IAMLMK.NMVFRHNVSPNVEKRMGSIFKKQFFAMENEVQ.EEYTRKMVALTAECNLETR.KEMEVQHQRERAANDEAEELIKR.LNEKSAIEYRCLLEKIHKLEQSHMKRFLLVRQEEYFAKAYRQLAIF........QRTELHNIFFTQIKNAIFKGELKLEAAKALVQDYSKIQ..VDIEELMDFLQANKKYHLSKRFAYRECLINNIHLWDSQASSLLNTAASQITSLINKME..RAGHLSENHLGPLLDQAQAEVHSVKQKLDHNL................
F1PZ45_CANLF/274-697                 ............................GDSFSVSYTASIKAG..EVGSGEV...LLLPAQLTFQ........-SSA.QNKTQLK---ALFTITAE..EKIKVVPNHGLHAAGFFTASV..ISFVLTWVTLFFM.ARYQCLKGGPFARHQ.VQ.--HHESKL.EH.SQFTSADGVNEDLA.........LNDQMIDILSSEDPGSMLQALEE.LE......IATLN..RAD..SDLEACRTQISRDI..IALLLK.NLSSSGHLSPQVERKMSAVFKKQFLLLEKEIQ.EEYDRKMVALTAECDLEMR.KKTESQYQREMAAMEEAEELLKR.VSERSAVECSGLLRTLHGLEQVHLRRSLALQQEEDFAKAHRQLAIF........QRNELHNIFFTQIKSAVCQGELKPEAAKMLLQDYSDVQ..EKLEELMDFFQASKRYHLSKRFGHREYLVQNMQSSEIRVQGLLSAADAQLTLFIQKHE..RAGYLDEEQMEALLERARMEVFSIKQKLDNDL................
H3D093_TETNG/239-663                 ............................GSQVIVNYTAHIRSH..---KIDL...LDLPAFLTFS........NASQ.NDVSMFGPLTANLTLRVN..STDRIQPNHDAHFAGFVVGFF..VTIVLLSLGFLAI.NLTDSRTRLNILQQN.--.KKRRDSDI.NN.ADCDLDESFKEEAA.........FEDKIVDIMVLKRGFHCMNNSTS.LE......MSTLL..RAT..NNLEVTRIQIYKDV..MSLLLG.DLPSRGHTSVQTQQRLLSVLDGQLLGMEGRLK.EERGARMTALANRCNLESR.EEMEAEHHREAAEKAQAKLLCKQ.ADQQELLHCSVLMEKLHKLKQSQLQDKLLVQHEEASAKVQRQIIEW........RRVELHKIFSEELEESTRMGEMERKTAESLQHEYFDCQ..DYLEEVLDMILANQRYVLAERHAQRKFLVHSLHSLNGLISDTFSITSDSLDNWFSQIK..RGSTLPAEQVDQLQDKAQKELVMVRQRLDET-m...............
H2PCV7_PONAB/237-660                 ............................GDAFVVSYAATLQAG..DLGNGES...LKLPAQLTFQ........-SSS.RNRTQLK---ALFSITAE..ENITVLPHHGLHAAGFFIAFL..LSLVLTWAALFLM.VHYQCLKGNMFTRHR.VW.--QYESKL.EP.LPFTSADGVNEDLS.........LNDQMIDILSSEDPGSTLQALEE.LE......IATLN..RAD..ADLEACRTQISKDI..IALLLK.NLTSSGHLSPQVERKMSAVFKKQFLLLENEIQ.EEYDRKMVALTAECDLETR.KKMENQYQREMMAMEEAEELLKR.ASERSAVECNNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVF........QRNELHSIFFTQIKSAIFKGELKPEAAKTLLQNYSKIQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHE..RAGYLDEDQMEMLLERAQTEVFSIKQKLDNDL................
G1S1Y1_NOMLE/1-326                   .........................kvw---------------..-------...----------........----.------------------..---------------------..-------------.---------------.--.--QYESKL.EP.LPFTSADGVNEDLS.........LNDQMIDILSSEDPGSMLQALEE.LE......IATLN..RAD..ADLEVCRTQISKDV..IALLLK.NLTSSGHLSPQVERKMSAVFKKQFLLLENEIQ.EEYDRKMVALTAECDLETR.KKMENQYQREMMAMEEAEELLKR.ASERSAVECNNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVF........QRNELHSIFFTQIKSAIFKGELKPEAAKTLLQNYSKIQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHE..RAGYLDEDQMEMLLERAQTEVFSIKQKLDNDL................
H0WGP0_OTOGA/125-548                 ............................GDSFEVSYTASLQPE..GLRPGES...LKLPAHLTFQ........-STS.LNRTQLK---ALFTITAE..EKITVLPHHGLHAAGFFAAFL..LSLVLTWVGLFFM.VRYQCLQGNVFTRHR.VG.--HHESKL.EP.LLFTLEDGVNEDLS.........LNEQLIDILSSEDSGSTLQALKE.LE......IATLN..RAD..ADLEVCRTQISKDI..IALLLK.NLTSNGHLSPQVERRMGTIFKRQFLLLENEIQ.EEYDRKMVALTAECDLETR.KKTENQYQREMAAMEEAEELLKR.ASERSATECNNLLRTLHCLEQEHVRKSLALQQEEDFAAARRQLAVC........QRGELHGIFFTQVKSAVLKGDLKPEVAKMLLQNYSKIQ..ENVEELMDFFQATKRYHLSKRFGHREYLVQNLQSSETRAQGLLSTAAAQLTHLIQKHE..RAGYLDEDQMEMLLERAQTEIFSVKQKLDYDL................
G3SZ90_LOXAF/87-510                  ............................GDAFAVSYIALLVAR..HVRDGET...LLLPAQLTFH........-SSS.QNRTQLK---ALFAITAE..EKVTVLPNHGLHAAGFFVAFM..VSLALTWITLFFM.VRYQCLKGNMLNRHR.VQ.--HQGSKL.EH.SQFTSADGVNEDLA.........LNDQMVDILSSEDPGSMLQALED.LE......IATLN..QAD..SNLEACRTQISKDI..IALLLK.NLTSRGHLSPQVERRMGAVFKKEFLLLENEIQ.EEYDRKMVALTAECDLESR.KKTESQYQREMVAMEEVEELLKR.VSERSAAECSNLLRTLHGLEQERLRRALALQQEDDFAKAHRQLAIF........QRHELQRTFFTQIQSALVKGELKPEGAEMLLQDYSEMQ..GNVEELMDFFQATKRYHLSKRFGHREYLVQNMQSSEIRARGLLSAAAAQLTHLIQKHE..RAGYLDEEQMEMLLERAQTEVFSIKQKLDNDL................
L5LNW7_MYODS/91-514                  ............................GDSFSVSYTASLEAG..DRGRGEV...LVLPALLTFR........-SAS.ANRTQLK---ALLTITAE..ETVTVLPNHGLHAAGFFVAFI..VSLVLTWVTLFFM.VRYQCFKRSMFTRYQ.A-.-RHQESRL.EH.SQFTAAGGVNEDLA.........LNDQMIGILSSEDPGSMLQALEE.LE......IATLN..RAD..SDLEACRTQISKDV..IALLLR.DLSSGGHLAPQAERRMGAAFKKQFLMLEKEIQ.EEYDRKMVALAAECDLETR.KKMENQFQREAATMEEAEELLKH.VSERSAGECSSLLRTLHGLEQEQLRRSLALQQEEDFAKAHRQLAVF........QRSELHSIFFAQIKSAIFKGDLQPEAAKMLLQDYSRIQ..EEVEELMDFFQASKRCHLSKRFGHREYLVQTMQSAETRVQGLLSAAAAQLTLLIQKHE..RAGYLDEEQTEELMERAQTEVFSIKQKLDNDL................
C3Y3M0_BRAFL/480-918                 ............................GEELLLSFQAEMECK..ERECAESspnLTIPANVTYRsvavqqaaNSTQ.FQGIDYGPLMDSICLGFDlvELTSLFRNYGYIGLALVVFLL..VGIVVGLLCCFLL.GRTRGMQVRPL----.--.----RGRS.KK.KKGGLFSGLKNRLKglg...swfGELNFASILTFRDISKMFRWLDN.LD......IKSSI..DLD..IKLQGHRLQLMINS..INIQLQ.KLRHKGEISRPILDRVQDKFNKAWRALCRRLG.EEYQKALSRLHKRLAAKNK.DNVDSLHKKHEEERKQLIDRTTN.TPEKERRELVKLLDQQHQVETEELSYRLQLEQAEEEEKIRKEFELK........KRVGLKELQHNLLKDLAEQAELSEEEAARIMREHKENQ..ATINRLMDEEMSRQRMLLEEKLAQRRAMAKAKEHQEDHNKKVLNTLATQQAGIVQEMR..EDGKLSAEQEQMFKERIRREMLAARERHDKSR................
G3P033_GASAC/53-475                  ............................GSQVVVNYTAHIRNH..---KSEV...MDLPAFVTFS........NASQvFKRCTFL---VFMSYTFD..LMRSIHPNHGVHLAGVVAGFF..GTLMLLSLGFLAV.NLIGLRTRLNLFQQK.--.RNRGDSEP.EY.AECNMSEAVKDEAA.........FEDKMVDTMVLEDPQNMYQALEN.LQ......MSTLL..HAT..NNLEATRIQIYRDV..MSSLLG.SLRSRGQASAQAQQRLLSVLHGQMLGMEGRLK.EERGARMAALAGRCNQETR.EEMEAEHRTEAAQKAQAELLCQH.ANQQELLHCSVLLEKLHKLSQSRLQRILLVRHEEASGKVQRQIVEW........RRVELHKIFSEELEEATRMGELEKSAAKSLQHDYFASQ..DQLEEVLDVVLANQRYVLAERHAQRKFLVHSLHSLNNLISDSFSSTSSNLDSWFTHIR..RGGSVPSEQLDQLQDKAQKELVMVRQRLEEAL................
F6T7X1_XENTR/123-549                 ............................GEYLLIKYNASLSSG..LATDGLQ...LSLPAQLSFQ........NSSA.VAGTSLR-LMAAFTVTAK..ENIKVLPNHGLHALGFVIGFL..VSFLLTCAVLLVL.RYTKRLNCRCLGNLH.--.GTNCEPKL.GK.SQSNSPDNVNEDFN.........MPDKMIDILAFEEPENMLQALDD.SE......IVNLT..HAD..AYLEACRIHVCKDI..IGISLK.NMAATVHLPHYEVKRLTAAMSEQWINLEKQIQ.EEHQRKIVALTAECHLDTR.KQVDMQERKQKAVYEEAEEKFRH.AGEKSLTEYRLLLDKLHDMERAEMMKLLMYKQEEDFAKARRELSVC........HRTELLGIFSEQLHDSVAKGNITADAGTAVIENHFKIQ..EEAEDLLDFIQADKKCRMNRTLAARKNIIYIMQLCDSRSRCLLNTAAAQIASLINKTE..RAGHMNENQAELLMCRAQAEVSRVKQKMDNVL................
F6R759_CALJA/231-496                 ............................GDAFAVSYTATLQAG..DIWNGES...LKLPAQLTFQ........-SLS.RNRTQLK---ALFTITAE..ENIRVLPNHGLHAAGFFSAFL..VSLVLTWAALFLM.VRYQCLKGNLLTRRR.VW.--RHESKL.EP.LPFTSADGVNEDLS.........LNDQMIDILSSEDPGSMLQALEE.LE......IATLN..RAD..ADLEACRTQISKDV..LALLLK.NLTNNGHLSPQVERKMSAVFKKQFLLLDNEIQ.EEYDRKMVALTAECDLETR.KKMENQYQREMMAMEEAEELLKR.ASERVR----------------------------------------........--------------------------------------..----------------------------------------------------------..--------------------------------qsslnkihtk......
F6XGD8_MONDO/65-491                  ............................GDFYSVSYSALLKAK..EARNSKI...LSLPAHLTFQ........-SLS.LNKTELK---ALLTIRRQ..EKTKVSPNHGAHTAGFFIAFL..VSLVLTFVIFLFM.SQSQCFKWNICNKNR.VQqSPHQESKL.EY.SQFTSVDGVSEEFA.........IGDQIIDILLSEEPASMVQALED.ME......IATLT..RAD..VDLQACRMQISKDI..IGMLLK.NLILSGNLSPHMEKRMSSVFKKQFLKMETEVQ.EEYDRKMVALNAECNLEMR.KKTEAQCQREMVAMEEAEELLKR.VSERSALEYRNLLHNLHRREQDHLRKSLLLKREEDFAKAYRELAIF........QRNELHNIFFTQIKSAVLKGDLKLETTKMLLQDYSKIQ..ENIEELMDFLQANKKYHLSKRFGYREYLIQSIQSLETWNQSLLNTATAQITSLIHKNE..RAGYLDEDQMETLLARAQAEVLSVQHKLENDL................
M3ZBJ7_NOMLE/157-215                 ............................GDAFAVSYAATLQAG..DLGIGES...LKLPAQLTFQ........-SSS.RNRTQLK---ALFSITAE..ENITV----------------..-------------.---------------.--.--------.--.--------------.........-----------------------.--......-----..---..--------------..------.--------------------------------.-------------------.-----------------------.----------------------------------------------........--------------------------------------..----------------------------------------------------------..--------------------------------rdmt............
A0A0P7UEV3_9TELE/248-355             ............................GSLYAVKYTAIVQGR..---GDAT...LELPAYLTFT........NASQ.NDVNLFGPLVSSLTLKIN..STEKIYPNHGVHFAGFMAAFV..PVLSLGLL---LF.RKMGTADGRN-----.--.--------.--.--------------.........-----------------------.--......-----..---..--------------..------.--------------------------------.-------------------.-----------------------.----------------------------------------------........--------------------------------------..----------------------------------------------------------..--------------------------------plqqrwlqagldpvst
G1NJC2_MELGA/158-588                 ............................GEYFAINYSALLDAK..KTWNGRV...LTLPAQLTFR........-SLS.QNQTDLVSLTTLFTITEE..EKTEVSYSHAIHASGFFIAFF..VSLVLTCAVFFVL.YRTQLLRWSFYSKNQeIQhELSQNHKL.EH.SHFNSGDLFSEDVI.........MNDQIIDILTFEESGNMLQALED.LE......VASLT..RAD..ADLEAYRMQICKEV..IVMMMK.NMVLSHSLIPHVEKRMSSVFKKQFLTMEREFQ.EEYERKVVALTAECNLETR.KKMEAQRQKERAANEEAEELMKK.VSEMPAVEYRSLLDRLHSLEQDHLKRFLLVKQEEYFAKAYRQLTVS........QRKELHNIFFTEITNATFKGELKLEIAKSLVEDYSKIQ..GDIEELMDFLQASKKYHLNRRFAYREYLIRKIQLRDSQASALINAAATQILNLINKME..RAGHLHESHLEMLLDRAEAEINSVKQKFDHDL................
I3L853_PIG/64-480                    ............................GDSFSVQYTAWLEAG..GVGSGEV...LMLPALLSFQ........-TSS.PNRTQLK---ALLTITTD..EKITVLPNHGLHAMG------..XSLLLTWAVLFFM.VRYQCLKGSLLSRHR.LS.--NHHAKS.DR.LKITTLSERTEEKD.........RNGSGVPIMALTLAGKMLQKPERwLE......IATLN..RAD..SDLEACRTQISKDI..IALLLK.NLTSSGHLSPQGARRMDAIFQKQFLWLEKEIQ.EEYDRKMVALTAECDLDTR.KKTESQYQREMAAMEEAEEVLKR.GSERSAAECSSLLRTLHGLEQEHLRRSLALQQEEDFAKAHRQLAIF........QRSELHSIFFTQIQSAIFKGELKPEAAKMLLQDYSKIQ..VNASKVLSIYKSQEFYHIPGQHSHSGNSVT--LSSGSRMHLLLSLCSGQRSLSIQKHE..RAGYLDEDQMEVLLERVQTEVFSIKQKLDNDL................
U3K4E6_FICAL/169-599                 ............................GEYFAINYSALLDAE..EMWHGRV...LTLPAKLTFR........-SSS.QNKTHLVSLTASFTITEE..EKTKILYSHAISASGFFIAFF..ISLVLTCAVFFII.YRTQILKWSFCSTNQeIQpDLSQSHKL.EH.SQFNSGDLFSEDTI.........VNDQIIDILSFEEPGNMRQALED.LE......VASLT..RAD..ADLEASRTQICKEV..IAMMLK.NMVLNHSLFPHVEKKISSVFKKRFLAMEKEIQ.EEYERKMVALTAECNLETR.KTMEAQCQKVRAANEEAEELMKK.INEKPAVEYRSLLDKLHRLEQDCLKRFLFVKQEEYFAKAYRELAVT........QRKELHSIFFTQITNATSKGELKLEAVKTLVEGYSKIQ..GDIEELIDFLQASKKYHLNKRFSYREYLISTIQSRDSHVSALINAAAAQISSLINKTE..RAGHLPESHLGILLDRAETEINFVKQKFDHDL................
F7HNC8_MACMU/157-580                 ............................GDAFAVSYAATLQAG..DLGNGES...LKLPAQLTFQ........-SSS.QNRTQLK---ALFSITAE..ESITVLPHHGLHAAGFFIAFL..LSLVLTWAALFLM.VHYQCLKGSMLTRHR.VW.--QYDSKL.EP.LPFTSADGVNEDLS.........LNDQMIDILSSEDPGSMLQALEE.LE......IATLN..RAD..ADLEACRTQISKDI..IALLLK.NLTSSGHLSPQVERKMSDVFKKQFMLLENEIQ.EEYDRKMVALTAECDLETR.KKMENQYQREMMAMEEAEELLKR.ASERSAVECNSLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVF........QRNELHRIFFTQIKSAILKGELKPEAAKTLLQNYSKIQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHE..RAGYLDEDQMEMLLERAQTEVFSIKQKLDNDL................
F6R759_CALJA/504-606                 ........................fkrv---------------..-------...----------........----.------------------..---------------------..-------------.---------------.--.--------.--.--------------.........-----------------------.--......-----..---..--------------..------.--------------------------------.-------------------.-----------------------.----------------------------------------------........-----------------------------LLILYWRLK..ENVEELMDFFQANKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHE..RAGYLDEDQMEVLLERAQTEVFSIKQKLDNDL................
M3Y955_MUSPF/228-651                 ............................GDSFLVSYTASIKAG..EVGSGEV...LMLPAQLTFQ........-SSA.QNRTQLK---ALFTITVE..EKIKVVPNHGLHAAGFFAASI..VSFVLTWVTLFFT.ARYQCLKGSLLTRHG.VQ.--HPESKL.EH.SQFTSPDDVNEDLA.........LNDQMIDILSSEDPGSMLQALEE.LE......IATLN..RAD..SDLEACRTQISRDI..IALLLK.NLTSSGHLSPQVERRMGAVFKKQFLLLEKEIQ.EEYDRKMVALTAECDLEMR.KKTESQYQREMAAMEEAEELLKR.VSERSAVECNGLLRTLHSLEQVHLRRSLALQQEEDFAKAHRQLAVF........QRNELHNIFFTQIKSAIFQGELKPEAARMLLQDYANIQ..EKLEELMDFLQASKRYHLSKRFGHREYLVQNMQSSETRVQGLLSAADAQLNLFIQKHE..RAGYLDEEQTEALLGRTQTEVFSIRQKLDNDL................
G3P019_GASAC/136-555                 ............................GSQVVVNYTAHIRNH..---KSEV...MDLPAFVTFS........NASQ.NDVSMFGPLTANLTLR--..----IHPNHGVHLAGVVAGFFgtVFSQLFYLFF-IY.FRYASRQCACIFLQQ.--.RNRGDSEP.EY.AECNMSEAVKDEAA.........FEDKMVDTMVLEDPQNMYQALEN.LQ......MSTLL..HAT..NNLEATRIQIYRDV..MSSLLG.SLRSRGQASAQAQQRLLSVLHGQMLGMEGRLK.EERGARMAALAGRCNQETR.EEMEAEHRTEAAQKAQAELLCQH.ANQQELLHCSVLLEKLHKLSQSRLQRILLVRHEEASGKVQRQIVEW........RRVELHKIFSEELEEATRMGELEKSAAKSLQHDYFASQ..DQLEEVLDVVLANQRYVLAERHAQRKFLVHSLHSLNNLISDSFSSTSSNLDSWFTHIR..RGGSVPSEQLDQLQDKAQKELVMVRQRLEEAL................
H2UVR6_TAKRU/110-534                 ............................GSQVIVNYTAQIRSH..---KIEV...LDLPAFLTFS........NASQ.NDVSMFGPLTTNLTLRVN..STDRIHPNHSAHFAGFVVGFF..VTIVLLSLGFLAM.NLTGSRTRLNLLQQR.--.RKREDSDP.DD.ADCNIDETIKEEAA.........FEDKIVDTMVLEEPQNMYQSLEN.LE......MSTLL..RAT..NNMEATRIQIYKDV..MSSLLG.GLLSQGHASMQTQQRLLSVLYGQLLGMEGRLK.EERAARMAALANQCNLESR.EEMEAEHHRETAEKAQAELLYKQ.ADQQELLRCSVLLEKLHKLRQSRLQAKLLVQHEEASAKVQRQIIEW........RRVELHKIFSEELEEATRMGEMERSTAKSLQHEYFDCQ..DHLEEVLDVVLANQRYVLAERHAQRKFLVHSLHSLNSLISDTFSITSNNLDNWFCQIR..RGSTLPVEKVDQLQDEAQKELVMVRQRLDEAL................
I3MBP0_ICTTR/237-660                 ............................GDSYWVTYTAWLDSE..AVGTGER...LTLPAQLTFQ........-SSS.PNRTQLK---ALLTITAE..EKVTVLPNHGLHAAAFFTAFL..VSLALSWTVLFFF.ARYQCLQGGVLARRR.VQ.--RAESKL.EP.SPFTSAGGVNEDLS.........LNDQMVDILTSEDPGSMLQALEE.LE......IATLN..QAD..ADLEACRTQISKDI..IALLLR.SLTSGGHLSPQAERRMALVFRKQFLLLEKEVQ.EEYDRKMLALTAECDLETK.KKTENQYQREMLATEEVEELLKR.VSERSAAECRGLLRTLHGLEQEHLRSALALHQEEDLAQAHRQLAIF........QRNELHSIFFAQIKSAILKGDLKPEAAKMLLQDYSKLQ..ENVEELMDFFQATKRYHLSKRFGHREYLVQNLQCTETRVQGLLSTAAAQLTQLIQKLG..RAGYLDEDQMEVLLERAQTEVFSIKQKLENDL................
H3C639_TETNG/239-663                 ............................GSQVIVNYTAHIRSH..---KIDL...LDLPAFLTFS........NASQ.NDVSMFGPLTANLTLRVN..STDRIQPNHDAHFAGFVVGFF..VTIVLLSLGFLAI.NLTDSRTRLNILQQN.--.KKRRDSDI.NN.ADCDLDESFKEEAA.........FEDKIVDIMVLKRGFHCMNNSTS.LE......MSTLL..RAT..NNLEVTRIQIYKDV..MSLLLG.DLPSRGHTSVQTQQRLLSVLDGQLLGMEGRLK.EERGARMTALANRCNLESR.EEMEAEHHREAAEKAQAKLLCKQ.ADQQELLHCSVLMEKLHKLKQSQLQDKLLVQHEEASAKVQRQIIEW........RRVELHKIFSEELEESTRMGEMERKTAESLQHEYFDCQ..DYLEEVLDMILANQRYVLAERHAQRKFLVHSLHSLNGLISDTFSITSDSLDNWFSQIK..RGSTLPAEQVDQLQDKAQKELVMVRQRLDET-m...............
A0A096NZD3_PAPAN/237-660             ............................GDAFAVSYAATLQAG..DLGNGES...LKLPAQLTFQ........-SSS.QNRTQLK---ALFSITAE..ESITVLPHHGLHAAGFFIAFL..LSLVLTWAALFLM.VHYQCLKGSMLTRHR.VW.--QYDSKL.EP.LPFTSADGMNEDLS.........LNDQMVDILSSEDPGSMLQALEE.LE......IATLN..RAD..ADLEACRTQISKDI..IALLLK.NLTSSGHLSPQVERKMSDIFKKQFMLLENEIQ.EEYDRKMVALTAECDLETR.KKMENQYQREMMAMEEAEELLKR.ASERSAVECNSLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVF........QRNELHRIFFTQIKSAILKGELKPEAAKTLLQNYSKIQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHE..RAGYLDEDQMEMLLERAQTEVFSIKQKLDNDL................
LBN_MOUSE/147-570                    ............................GECYSVSYTASLDPT..ALGTGES...LDLPARLIFQ........-SPS.QNRTQLK---APFTITVE..EKIMVLPNHGLHAAGFIAAFL..ISLLLTVAALFFL.ARGRCLQGGMLSRCR.IQ.--HPENKL.EP.SPFTSANGVSQDLS.........LNDQVVAILTSEEPGSMLQALEE.LE......IATLN..QAD..ADLEACRNQISKDI..IALLMK.NLVSGGHLSPQTERKMAAAFKKQFLLLENEIQ.EEYERKMLALTAECDLEMR.KKTENQYQREMVAMEEAEEVLKR.VSERSAAECSSLLRTLHGLEQEDMQRSLTLDQAEDFAQAHRQLAVF........QRNELHSIVYTQIQSAVSKGELRPEVAKMMLQDYSKTQ..ESVEELMDFFQATKRYHLSKRFGHREYLVQRLQAMETRVQGLLNTAATQLTSLIHKHE..RAGYLDEDQMETLLERAQTETFSIKQKLDNDL................
W5MV80_LEPOC/212-638                 ............................GSCYTVKYSAQMKGE..---QNDI...LSLPAYLTFS........NASQ.NDINLFGPVVANFTLRVN..STAKVSSNHGIHFVGFLVGFL..VASILMTLAFLLF.SWIGIPQMSCCKRKR.RG.GLSGDTDP.EY.AVCNVSETAKEEAA.........FEDKIVDIMILEDPQNMYQALEN.LD......MSTLL..RAA..ASLESFRVQVYKDL..VAMLLR.NLKMNGGVSALAEKRLNSVLNGQLMGMEGKLK.EEHVARMAALAAECNRETR.EEMEAEHRRVTVEKAQAEHLFQQ.ADQQVVLELSVLLDKLHKLDQSYLQRCLLVRHEEASAKVQRQTVVC........RRLELHKIFFEELEEATRMKELEKNVANQLLHAYFSSQ..DQLEEVLDIFLANQRSILEERHAQRQFLAHSLQSLKTLICEVFTNTSRQMENWFQDLK..NERYVTEEQANLLLDKAKKELLHVKQNLDEGL................
V3YXV9_LOTGI/182-290                 ........................syas---------------..-------...-----FVQFS........DSAS.VIYSTVK---PTVCVTRTtvLQKSLFYQHGFTALSFFMAFI..LGILLVILIVFCI.VTIMKKKGLMA--TS.IS.----PSKL.DV.SSSNSSRTIV----.........-----------------------.--......-----..---..--------------..------.--------------------------------.-------------------.-----------------------.----------------------------------------------........--------------------------------------..----------------------------------------------------------..--------------------------------geqrklketgkkiv..
M4AVJ8_XIPMA/238-662                 ............................GSHVVVNYTAHVRSH..---NNEL...LDLPAFLTFS........NASQ.NDVSMFGPLRANLTLRVN..STDRIYPNHGVHFAGFVAGFF..ITLVLLLLGVLAI.KFTSSRERFCLFQRK.--.RNRCHLDP.EY.ADSSMSETIKDEAA.........FEDKMVDVMVLEDPQNMYQALDN.LE......TSSLL..QAS..SNLEATRIQIYKDL..MSCLLG.GLLSRGQISAQAQQRLLSVVHGQLLGMEGRLK.EERGARMAALAGQCNLETH.EEMEAEHQEQAAEKAEAERLRQH.ADQQEFLQCSRLLEKLHKQRQSHLRRVLLVQREDASAKVQREIIEW........RRVELHKIFSEELEEATRMGELEKSTAKRLQHEYFTCQ..DQLEEVLDVVVANQRYVLTERSAQRKFLVHSLHSLEDLISETFSSASSNLDSWFSHIK..SGSAVPSEQLDQLQEKAQKDLVMVRQRLDETL................
A0A091D6A2_FUKDA/157-580             ............................GNSYLVSYSASLDPG..AISTRER...LILPAQLTFQ........-SSS.LNRTQLQ---ALFTITVA..ERVTVLSHHGLHAAGFFIAFL..VSLVLSWVALFFL.ARCRCLPGSLLAGHQ.MQ.--DPESKL.EP.SPFTSANGISEDLT.........LNDQMIDILTSEDPGRMLQALEE.LE......IATLN..QAD..ADLEACRTHISKDI..IGLLLR.SLTSGGHLSPQVERRIGSVLKEQFLLLENEVQ.EECDRKMLAWTAECDLETR.KKTENQYQKEREAMEEAEELLKR.VSERSAAEYSSLLRTLHGLEQEHLWRSLALHQEEDFAQAHRQLAIF........QRNELHSVFFAQIKNAIFKGELKPEAAKMLLQDYSKLQ..ENIEESMDFLQATKRYHLSKRFGHREYLVQNLQSTETHVQGLLSAAAAQLTHLIQKHE..RAGYLDEDQMEMLLERVQMEVFSIKQKLDNDL................
W5PAS6_SHEEP/228-651                 ............................GDSFSVSYTASLEAR..DVRSGDI...LLLPAHLSFQ........-SSS.PNRTQLR---APFAITAE..EKITVLPNHGLHAAGFCVAFI..LSLVLTWAVLFFM.VRYQCVKGSSLSRHQ.VQ.--HHENKL.EH.SQFTSADGVNEDLA.........LNDQMIDILSSEDPGSMLQALEE.LE......IATLN..RAD..SDLEACRTQISKDI..IALLLK.NLTSSGQLSPQVERRMGAVFKKQFLLLEKEIQ.EEYDRKMVALTAECDLETR.KKTESQYQREMAALEEAEEVLKR.VSERSAVECSSLLRTLHGLEQEHLRRSLALQQEEDFAKAHRQLAIF........QRNELHNIFFTQIKSAISKGELKPEAAKMLLQDYSKIQ..ESVEELMDFFQASKRYHLSKRFGHREYLVQNIQSSETRVQGLLSTASAQLTLLIQKHE..RAGYLDEDQMQVLLERAQTEVFSIKQKLDNDL................
M3W1I7_FELCA/228-651                 ............................GDSFSVSYTASIQAG..EIGSGDV...LMLPAWLTFQ........-SSA.PNRTQLK---ALLTITAE..EKIKVVPNHGLHAAGFFIASI..ASFVLTWATLFFT.ARYQCLKGSLITRHQ.VQ.--HHESKL.EY.SQFTSANGINEDLA.........LNDQMIDILSSEDPGSMLQALEE.LE......IATLN..RAD..SALEACRTQISRDI..IALLLK.HLTSAGHLSPQVERRMGSVFKTQFLLLEKEIR.EEYDRKMVALTAECDLETR.KKTENQYQREMAAMEEAEELLKR.VSEKWAVECNGLLRTLHGLEQEHLRRSLALQQEEDFAKAHRQLAIF........QRNELHNIFFTQIQSAVFQGELKPEAAKTLLQDYSGIQ..EKLEELMDFFQASKRYHLSKRFGHREYLVQNMQSSETRVQGLLSAADTQLTVFIQKHE..RAGYLDEDQMEALLQRTQTEVFSIKQKLDNDL................
G5B315_HETGA/155-578                 ............................GDSYLVSYSASLERG..AVVTGER...LSLPAQLTFQ........-SSS.RNRTQLQ---ALFTITVA..ERITVLPHHGLHAAGFFIAFL..ISLVLSWVALFFL.ARYWCLPGSLLAGHQ.TQ.--HPESKL.EP.LPFASADGISEDLS.........LNDQMIDILTSEDPGSMLQALEE.LE......IATLN..RAD..ADLEACRTQISKDI..IGLLLR.SLTSGGHLSPQVERRIGSVLKKQFLLLENEVQ.EEYDRKMLALTAECDLEMR.KKTENQYQKEMVAMEEAEELLKC.VSERSAAEYSSLLRTLHGLEQEHLWRSLALHQEEDFAQAHRQLAVF........QRNELHSIFFAQMKNAIFKGELKPEAAKMLLQDYSKLQ..ENIEESMDFLQATKRYHLSKRFGHREYLVQNLRSTETRVQGLLSAAAAQLTQLIQKHE..RAGYLDEDQMEMLLERVQMEVFSIKQKLDNDL................
LBN_HUMAN/237-660                    ............................GDAFAVSYAATLQAG..DLGNGES...LKLPAQLTFQ........-SSS.RNRTQLK---VLFSITAE..ENVTVLPHHGLHAAGFFIAFL..LSLVLTWAALFLM.VRYQCLKGNMLTRHR.VW.--QYESKL.EP.LPFTSADGVNEDLS.........LNDQMIDILSSEDPGSMLQALEE.LE......IATLN..RAD..ADLEACRTQISKDI..IALLLK.NLTSSGHLSPQVERKMSAVFKKQFLLLENEIQ.EEYDRKMVALTAECDLETR.KKMENQYQREMMAMEEAEELLKR.AGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVF........QRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHE..RAGYLDEDQMEMLLERAQTEVFSIKQKLDNDL................
L7N188_MYOLU/1-96                    ........................dflf---------------..-------...----------........----.------------------..---------------------..-------------.---------------.--.--------.--.--------------.........-----------------------.--......-----..---..--------------..------.--------------------------------.-------------------.-----------------------.----------------------------------------------........------------------------------------EQ..EEVEELMDFFQASKRYHLSKRFGHREYLVQNMQSAETRVQGLLSAAAAQLTLLIQKHE..RAGYLDEEQTEELMERAQTEVFSIKQKLDNDL................
H2QP60_PANTR/237-660                 ............................GDAFAVSYAATLQAG..DLGNGES...LKLPAQLTFQ........-SSS.RNRTQLK---ALFSITAE..ENITVLPHHGLHAAGFFIAFL..LSLVLTWAALFLM.VRYQCLKGNMLTRHR.VW.--QYESKL.EP.LPFTSADGVNEDLS.........LNDQMIDILSSEDPGSMLQALEE.LE......IATLN..RAD..ADLEACRTQISKDI..IALLLK.SLTSSGHLSPQVERKMSAVFKKQFLLLESEIQ.EEYDRKMVALTAECDLETR.KKMENQYQREMMAMEEAEELLKR.ASERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVF........QRNELHSIFFTQIKSAIFKGELKPEAAKTLLQNYSKIQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHE..RAGYLDEDQMEVLLERAQTEVFSIKQKLDNDL................
E1BES3_BOVIN/137-562                 ............................GDSFSVSYTASLEAR..DVGSGDI...LLLPAQLSFQ........-SSS.PSRTLHA---YPLVVTCL..ERCEVLPNHGLHAAGFCVAFI..LSLVLTWAVLFFM.VRYQCVKGSSLTRHQ.VQ.--HHENKL.EH.SQFTSADGVNEDLA.........LNDQMIDILSSEDPGSMLQALEE.LE......IATLN..RAD..SDLEACRTQISKDI..IALLLK.NLTSSGQLSPQVERRMGAVFKKQFLLLEKEIQ.EEYDRKMVALTAECDLETR.KKTESQYQREMAAMEEAEEVLKR.VSERSAVECSSLLRTLHGLEQEHLRRSLALQQEEDLAKAHRQLAIF........QRNELHNIFFTQIKSAIFKGELKPEAAKMLLQDYSKIQkqESVEELMDFFQASKRYHLSKRFGHREYLVQNIQSSETRMQGLLSTASAQLTLLIQKHE..RAGYLDEDQMQVLLERAQTEVFSIKQKLDNDL................
F1NTF8_CHICK/231-661                 ............................GEYFAINYTALLDAK..KTWKGRV...LTLPAQLTFR........-SSS.QNQTDLVSLTTLFTITEE..EKTEVSYSHAIHASGFFIAFF..VSLVLTCAVFFIL.YRTQLLRWSFYSENQeIQhELSQNHKL.EH.SQFSSGDLFSEDVI.........MNDQIIDILTFEESGNMLQALED.LE......VASLT..RAD..ADLEAYRMQICKEV..IAIMMK.NMVLSHSLIPHVEKRMSSIFKKQFLTMEREFQ.EEYERKVVALTAECNLETR.KKMEAQRQKERAANEEAEELIRK.VNEMPAVEYKSLLDRLHSLEQDHLKRFLLVKQEEYFAKAYRQLAVS........RRKELHNIFFTQITNATFKGELKLEIAKSLVEDYSKIQ..GDIEELMDFLQASKKYHLNRRFAYREYLIKKIQLRDSQASALINAAATQILNLINKME..RAGHLHESHLGMLLDRAEAEINSVKQKFNHDL................
H2UVR5_TAKRU/110-534                 ............................GSQVIVNYTAQIRSH..---KIEV...LDLPAFLTFS........NASQ.NDVSMFGPLTTNLTLRVN..STDRIHPNHSAHFAGFVVGFF..VTIVLLSLGFLAM.NLTGSRTRLNLLQQR.--.RKREDSDP.DD.ADCNIDETIKEEAA.........FEDKIVDTMVLEEPQNMYQSLEN.LE......MSTLL..RAT..NNMEATRIQIYKDV..MSSLLG.GLLSQGHASMQTQQRLLSVLYGQLLGMEGRLK.EERAARMAALANQCNLESR.EEMEAEHHRETAEKAQAELLYKQ.ADQQELLRCSVLLEKLHKLRQSRLQAKLLVQHEEASAKVQRQIIEW........RRVELHKIFSEELEEATRMGEMERSTAKSLQHEYFDCQ..DHLEEVLDVVLANQRYVLAERHAQRKFLVHSLHSLNSLISDTFSITSNNLDMFCASAT..RGSTLPVEKVDQLQDEAQKELVMVRQRLDEAL................
H2MQ97_ORYLA/136-560                 ............................GSYVAVNYTAFVRSH..---KSEI...LQLPAFLTFS........NASQ.NDVCMFGPLQANLTLRVN..STDAISPNHRVHFAGFAAGFL..VASALLSVGFLAM.NLAGPNAGLRLLQQR.--.RNRGDSDP.EY.ADCSMREAIKDEAT.........FEDNMVDVMVLEEPQNMYQALEN.VE......MSTLL..RAS..SNLELIRIQIYKDV..MSCLLG.GLQSERRTSIRAQERLLSVLHGQLLAMEGRLK.EDRGARMAALAGHCNLETR.EEMEAEHRREAAEKARAERLCQH.ADQQELLRCSVLLEKLHKLNQSRLQRTLLVRHEEASAKVQRQIVER........RRVELHKIFSEELEEAVRMDELEKSAAKSLLHKYFTCQ..DELEEVLDVVVANQRYVLSERSAQRRFLVHSLHSLNGLISDSFSTSSRTLDSWFAHVR..RGSLIPAEHIEPLQEKAQKELVMVRQRLDETL................
A0A087XL09_POEFO/242-666             ............................GSHVVVNYTAHIRSH..---KNEL...LDLPAFLTFS........NASQ.NDVSMFGPQRANLTLTVN..STDRIYPNHGVHFAGFVAGVF..ITLVLLLLGVLAI.KFTSSRERFCLFQQK.--.RIRCHLDP.EY.AESGMSDSIKDEAA.........FEDKMVDVMVLEDPQNMYQALDN.LE......TSSLL..QAS..SNLEATRIQMYKDL..MSCLLG.GLRSRAQISAQAQQRLLSVVHGQLLGMEGRLK.EERGARMAALAGRCNLETH.EEMEAEHQEQEAEKAQAERLRQH.ADQQEFLQCSRLLEKLHKQSQSHLRRVLLVRHEDGSAKVQREIIEW........RRVELHKIFSEELEEATRMGELEKSTAKRLQHEYFACQ..DQLEEVLDVVVANQRYVLAERSAQRKFLVHSLHSLEDLISETFSSASSNLDSWFSHIK..RGSAVPSEQLDQLQEKAQKDVVMVRQRLDETL................
A0A0C4DGE7_HUMAN/157-580             ............................GDAFAVSYAATLQAG..DLGNGES...LKLPAQLTFQ........-SSS.RNRTQLK---VLFSITAE..ENVTVLPHHGLHAAGFFIAFL..LSLVLTWAALFLM.VRYQCLKGNMLTRHR.VW.--QYESKL.EP.LPFTSADGVNEDLS.........LNDQMIDILSSEDPGSMLQALEE.LE......IATLN..RAD..ADLEACRTQISKDI..IALLLK.NLTSSGHLSPQVERKMSAVFKKQFLLLENEIQ.EEYDRKMVALTAECDLETR.KKMENQYQREMMAMEEAEELLKR.AGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVF........QRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHE..RAGYLDEDQMEMLLERAQTEVFSIKQKLDNDL................
F7HNC9_MACMU/237-660                 ............................GDAFAVSYAATLQAG..DLGNGES...LKLPAQLTFQ........-SSS.QNRTQLK---ALFSITAE..ESITVLPHHGLHAAGFFIAFL..LSLVLTWAALFLM.VHYQCLKGSMLTRHR.VW.--QYDSKL.EP.LPFTSADGVNEDLS.........LNDQMIDILSSEDPGSMLQALEE.LE......IATLN..RAD..ADLEACRTQISKDI..IALLLK.NLTSSGHLSPQVERKMSDVFKKQFMLLENEIQ.EEYDRKMVALTAECDLETR.KKMENQYQREMMAMEEAEELLKR.ASERSAVECNSLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVF........QRNELHRIFFTQIKSAILKGELKPEAAKTLLQNYSKIQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHE..RAGYLDEDQMEMLLERAQTEVFSIKQKLDNDL................
G1LXD6_AILME/162-585                 ............................GDSFSVSYTASIKAG..EVGSGEV...LMLPAQLTFQ........-SSA.QNRTQLK---ALFTITAE..EKIKVVPNHGLHVAGFFIASI..VSFVLTWVTLFFL.ARYQCLKGGLPTRHQ.VQ.--HHESKL.EH.SQFTSADGVNEDLA.........LNDQMIDILSSEDPGSMLQALEE.LE......IATLN..RAD..SDLEACRTQISRDI..IALLLK.NLASSGHLSPQVERRMGAAFKKQFLWLEKEIQ.EEYDRKMVALTAECDLETR.KKTESQYQREMAAMEEAEGLLKR.VSERSAMECSSLLRTLHGLEQVHLRRSLALQQEEDFAKAHRQLAIF........QRHELHNIFFTQIKSAIFQGELKAEAAKMLLQDYADIQ..EKLEELMDFFQASKRYHLSKRFGHREYLVQNMQSSETRVQGLLSTADTQLTLFIQKHE..RAGYLDEEQMETLLERVQTEVFSIKQKLDNDL................
K1PHU8_CRAGI/212-475                 tsqlyfastvltsvagpidldmcvygir---------------..-------...----------........----.-----------------N..VQKSIFYEQGFTALMFFIAFAlgIGLVIGAVCLFLMiKRKRAVQSKSFTQTN.LRiSTRGKTILmDDgDVNKTGHTITDFSNi.......rEDDSIVEVLVVKDKLKRFRELDN.LD......IVCTV..STD..TDIETQRADASLKA..TAMLIR.GLIFNRDISPQVYDAADKNMKQRRLLLDGNLD.TEFQRQNKKLRKKLAAKNK.AKLSRTLQRQREEKKKLVSEIAD.LGDNERKQLLDMMDQEHQTEL-------------------------........--------------------------------------..----------------------------------------------------------..--------------------------------neee............
G3WNX3_SARHA/141-567                 ............................GDVYTVSYRARLTAK..EAGDGKI...LSLPAQLTFQ........-SPS.LNKTQLK---ALLTVRGQ..EKAKVSPNHGAHAAGFFIAFL..VSLALTCIIFLFM.SQSRCFRWILCNKNR.VEqSPHQESKL.EY.SQFTFVDGVSEEFA.........ISDQIIDILSAEEPGSMVQALED.ME......IATLT..RAD..ADLQACRMQISKDI..IGMLLK.NLTLSGNLSPHMEKRMSSVFKKQFLMMETEVQ.EEYDRKMVALTAECTLEMR.KKTEAQCQREMAAMEEAEELLKH.VSERSALEYRNLLHNLHRREQDHLRKSLLLKREEDFAKAYRELAIF........QRNELHNIFFTQIKSAVLKGDLKLETAKMLLQDYSKIQ..ENIEELMDFLQANKKYHLSKRFGYTQYLIQSIQSLGTRDQSLLNTATAQIMSLIHKNE..RAGYLDEDQMETLLARAQAEVLSVQQKLENDL................
G3SIS4_GORGO/191-615                 ............................GDAFAVSYAATLQAG..DLGNGES...LKLPAQLTFQ........-SSS.RNRTQLK---ALFSITAE..ENITVLPHHSLHAAGFFIAFL..LSLVLTWAALFLM.VRYQCLKGNMLTRHR.VW.--QYESKL.EP.LPFTSADGVNEDLS.........LNDQMIDILSSEDPGSMLQALED.IS......IIING..RSL..VCVEICDTLLTKNS..IFLCLTlGLTTATHLSLKVKRKMSAVFKKQFLLLENEIQ.EEYDRKMVALTAECDLETR.KKMENQYQREMMAMEEAEELLKR.ASERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVF........QRNELRSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHE..RAGYLDEDQMEMLLERAQTEVFSIKQKLDNDL................
H0ZI81_TAEGU/123-548                 ............................GEHFAINYSALLDAE..EMWHGRV...LTLPVKLTFK........-SSS.QVFYSLF-YSALHKFCKK..PVSRILYNHAISASAFFIAFF..ISLVLTCAVFFII.YRTQVLKWSFCSKNQ.VS.--DQNHKL.EH.SQFNSGELFSEDII.........MNDQIIDILSFEEPGSMRQALED.LE......VASLT..RAD..ADLEANRTQICKEV..IAMMFK.NMVLNHNLFPHVEKKISSVFRKQFLAMEEEIQ.EEYERKMVALTAECNLETR.KTMEAQCQKARAVNEEAEELMKK.INEKPAIEYRSLLDKLHRLEQDCLKRFLFVKQEEYFAKAYRELAVT........QRKELHTIFFTQIINATSRGELKVEAAKTLVEGYSKIQ..GDIEDLMDFLQACKKYHLGKRFSYREYLISKIQSRDSHVSALINAAATQITSLINKTE..RAGHLPESHLGILLDRAEAEINFVKQKFDHDL................
H0VEZ5_CAVPO/234-659                 ............................GDSYLVSYTASLDPG..AISTLES...LSLPAQLTFQ........-SSM.LNRTQLQ---AVLTITVA..EKITVLPHHGLHAAGFFIGFL..LSLVLSWVALFLL.VHYRCLPGGLLAGHS.--.ALYAENKL.EP.SPFASADGISEDLS.........LNDQMIDILTSEDPRSMLQALEE.LE......IATLN..RAD..ADLEACRTQISKDI..IGFLLR.SLTCGGHLSPQVERRDRFCFEKSSFLLAGKMEvQTFDRQLFTLACGWAVENRvKGQKSEYKNKKLKMAEKDDMASW.GAEQSAAECSSLLRTLHGLEQEHVWKSLALHQEEDFAQAHRQLAVF........QRTELHGIFFAQIKNAIFKGELKPEAAKTLLQDYSKLQ..EHMEELMDFFQATKRYHLSKRFGHREYLVQNLQSTETRVQGILNTAATQLTHLIQKHE..RAGYLDEDQMEMLLERVQMEVFSVKQKLDNDL................
F7HND1_MACMU/157-580                 ............................GDAFAVSYAATLQAG..DLGNGES...LKLPAQLTFQ........-SSS.QNRTQLK---ALFSITAE..ESITVLPHHGLHAAGFFIAFL..LSLVLTWAALFLM.VHYQCLKGSMLTRHR.VW.--QYDSKL.EP.LPFTSADGVNEDLS.........LNDQMIDILSSEDPGSMLQALEE.LE......IATLN..RAD..ADLEACRTQISKDI..IALLLK.NLTSSGHLSPQVERKMSDVFKKQFMLLENEIQ.EEYDRKMVALTAECDLETR.KKMENQYQREMMAMEEAEELLKR.ASERSAVECNSLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVF........QRNELHRIFFTQIKSAILKGELKPEAAKTLLQNYSKIQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHE..RAGYLDEDQMEMLLERAQTEVFSIKQKLDNDL................
D3ZWN3_RAT/147-570                   ............................GECYSVSYMASLDPT..ALGPGES...LDLPAQLIFQ........-RPS.QNRTQLR---ARFTITVE..EKIMVLPNHGLHTAGFIAAFL..ISFLLTLAALFFL.ARGRCLQGSMLLRCR.VQ.--HPENKL.EP.SPFTSANGVSQDLS.........LNDQLVAILTSEEPGSMLQALEE.LE......IATLN..QAD..ADLEACRNQISKDI..IALLMK.NLISGGHLSLQTERKMAAAFKKQFLLLENEIQ.EEYERKMLALTAECDLEVR.KKTENQYQREMVAMEEAEEVLKR.VSERSAAECSSLLRTLHGLEQEDLQRSLTLQQAEDFAQAHRQLAVF........QRNELHSIVYTQIQSAVAKGELRPEVAKMLLQDYSKTQ..ESIEELMDFFQATKRYHLSKRFGHREYLVQRLQAMETRVQGLLSTAATQLTSLIHKHE..RAGYLDEDQMEMLLERAQTETFSIKQKLDNDL................
V3YXV9_LOTGI/367-670                 ........................ligp---------------..-------...----------........----.------------------..---------------------..-------------.---------------.--.--------.--.--------------.........-DDSIVHILGLKDKLQMFREIDN.LD......IVTTI..HVD..TDIEKEQNEAATQT..GLMLIH.NMTLNNDINKQTEDDVVNRFNNNLKTLDKKLD.DDYRKEMEIILIRLCARNK.EKVGEMLHRHNMEKEEVEENAAD.LTEKEKQDFLDILDKQQQTEQNELTYVLALEQNEEAEKLRKEFGIR........KRMGIREIQQIMINDVTEKGKLTQEQADWLIKEHKKQQ..DALQLLFDDEISRQRMTLEEKLARRRALAQASELQEDDQTDLLNTMAGHQVGVINKLK..KQNKLTDEEAEDMIEEVKKDMLNAKEKMDKE-k...............
I3NCM7_ICTTR/149-572                 ............................GDSYWVTYTAWLDSE..AVGTGER...LTLPAQLTFQ........-SSS.PNRTQLK---ALLTITAE..EKVTVLPNHGLHAAAFFTAFL..VSLALSWTVLFFF.ARYQCLQGGVLARRR.VQ.--RAESKL.EP.SPFTSAGGVNEDLS.........LNDQMVDILTSEDPGSMLQALEE.LE......IATLN..QAD..ADLEACRTQISKDI..IALLLR.SLTSGGHLSPQAERRMALVFRKQFLLLEKEVQ.EEYDRKMLALTAECDLETK.KKTENQYQREMLATEEVEELLKR.VSERSAAECRGLLRTLHGLEQEHLRSALALHQEEDLAQAHRQLAIF........QRNELHSIFFAQIKSAILKGDLKPEAAKMLLQDYSKLQ..ENVEELMDFFQATKRYHLSKRFGHREYLVQNLQCTETRVQGLLSTAAAQLTQLIQKLG..RAGYLDEDQMEVLLERAQTEVFSIKQKLENDL................
S9WQI5_9CETA/292-573                 .........................fsa---------------..-------...----------........----.------------------..---------------------..-------------.---------------.--.--------.--.--------------.........----------------------R.LE......IATLN..RAD..ADLEAYRTQISKDI..IALLLK.NLTSRGHLSPQVERRMGAVFKKQFLLLEKEIQ.EEYDRKMVALTAECDLEMR.KKTESQYQREMAAMEEAEEVLKR.VSERSAAECSGLLRSLHGLEQEHLRTSLALQQEEDLAKAHRQLATF........QRNGLHSIFFTQMKSAIFKGELKPEAAKLLLQDYSKAQ..ENVEELMDFFQASKRYHLSKRFGHREYLVQNIQSSETRVQGLLSTASAQLSLLIQKHE..RAGYLDEDQMEVLLERVQTEVFSIKQKLDNDL................
C3Y3M0_BRAFL/1064-1427               ............................GEELLLSFQAEMECK..ERECAESspnLTIPANVTYR........-SVA.VQQTA-------------..NSTQLFRNYGYIGLALIVFLL..VGIVVGLLCCFLL.GRTRGMQVRPLKRQR.YR.GSDSEGEL.DD.V-SLLKQQLQERISllseesqarMDD-DIETIRVEMLQERAQALKD.QEerlgglLSSLQmeRARelATIEEQREALNK-L..TTNLVD.ELSDKGVLTDPECKKVIEQHKKDVDKLEKKLH.HQRQRQEEELKKKLTEKMM.QREKSMLQLHEERLREI--HSQE.ASKTAARFKMAAMKNKYMMESEKQRQKMERGVEQNLEDYRRQWDMK........RKQALQEQELKFISGLVKTGRFEREELFSVLTLLFPHN..TDISQIL---------------------------------------------------..--------------------------------ekiyteeshssdes..
U3I932_ANAPL/129-558                 ............................GEYFAINYTALLDAK..ETWNGRV...LTLPAKLTFR........-SSS.QNKTHLVSLMASFTITEE..EKTKISYSHAIHASGFFIAFF..ISFVLTCAVFFIL.YQTKVLKWNFHSKNQ.IQhELSQNHKL.EH.SQFSSGDLFSEDVI.........MNDQVIDILTFEESKNMLQALED.LE......VASLT..RAD..ADLEAYRMQICKEV..IAIMMK.NMVLSHSLFPHVEKRMSSIFKKQFLAMEKEIQ.EEYERKVVAFTAECNLETR.KKMEAQRQKERAANEEAEELIKK.VNEKPAVEYRTLLDRLHRLEQDHLKRFLLVKQEEYFAKAYRQLAIS........QRKELHNIFFTQITNAALKGELKLEAAKTLVQDYSKIQ..GDIEELMDFLQASKKYHLNRRFAYREYLISKVQLMDSQASTLINAAATQISALINKME..RAGHLPESHLGLLLDRAETEINSVKQKFDHDL................
E9PFT2_HUMAN/157-413                 ............................GDAFAVSYAATLQAG..DLGNGES...LKLPAQLTFQ........-SSS.RNRTQLK---VLFSITAE..ENVTVLPHHGLHAAGFFIAFL..LSLVLTWAALFLM.VRYQCLKGNMLTRHR.VW.--QYESKL.EP.LPFTSADGVNEDLS.........LNDQMIDILSSEDPGSMLQALEE.LE......IATLN..RAD..ADLEACRTQISKDI..IALLLK.NLTSSGHLSPQVERKMSAVFKKQFLLLENEIQ.EEYDRKMVALTAECDLETR.KKMENQYQREMMAMEEAEELLKR.A---------------------------------------------........--------------------------------------..----------------------------------------------------------..--------------------------------vccrvq..........
I3KTK1_ORENI/242-666                 ............................GSQAVLNYTAHVRSQ..---KSEV...LDLPAFLTFS........NASQ.NDVSMFGPLTANLTLRMN..STDRIYPNHGVHFAGFVAGFF..VTMVLMLLGFLAI.NVIGLRTRLNLLQKR.--.RNRSDSDP.EF.ADSNLSETVKDEAT.........FEDKIVDTMVLEDPQNMYRALEN.LE......VSSLL..HAT..NNLEAVRIQIYKDV..MSSLLA.RLQSQGQASAQAQERLLSVLHGQLLGMEGRLK.EERGARMVALAGQCNLETR.EEMEAEHCREAAEKAQAELLCQH.ADQQELLQCSVLLEKLHKLSQGQLQRILLVRHEEASAKLQRQIIEW........RRVELHKIFSEELEEATRMGELEKSTAKNLQHEYFTCQ..DQLEEVLDVVLANLRYVLAERSAQRKFLVHSLHSLNSLISDTFSSTSSNLDSWFTYIR..GGSKLPAEQIDQLQEKAQKELVMLRQRLDEAL................
G3WNX4_SARHA/65-491                  ............................GDVYTVSYRARLTAK..EAGDGKI...LSLPAQLTFQ........-SPS.LNKTQLK---ALLTVRGQ..EKAKVSPNHGAHAAGFFIAFL..VSLALTCIIFLFM.SQSRCFRWILCNKNR.VEqSPHQESKL.EY.SQFTFVDGVSEEFA.........ISDQIIDILSAEEPGSMVQALED.ME......IATLT..RAD..ADLQACRMQISKDI..IGMLLK.NLTLSGNLSPHMEKRMSSVFKKQFLMMETEVQ.EEYDRKMVALTAECTLEMR.KKTEAQCQREMAAMEEAEELLKH.VSERSALEYRNLLHNLHRREQDHLRKSLLLKREEDFAKAYRELAIF........QRNELHNIFFTQIKSAVLKGDLKLETAKMLLQDYSKIQ..ENIEELMDFLQANKKYHLSKRFGYTQYLIQSIQSLGTRDQSLLNTATAQIMSLIHKNE..RAGYLDEDQMETLLARAQAEVLSVQQKLENDL................
G1P3L8_MYOLU/1-91                    ............................---------------..-------...----------........----.------------------..---------------------..-------------.---------------.--.--------.--.--------------.........-----------------------.--......-----..---..--------------..------.--------------------------------.-------------------.-----------------------.----------------------------------------------........-------------------------------------Q..EEVEELMDFFQASKRYHLSKRFGHREYLVQNMQSAETRVQGLLSAAAAQLTLLIQKHE..RAGYLDEEQTEELMERAQTEVFSIKQKLDNDL................
#=GC seq_cons                        ............................G-tasVsYsAplput..th.su-....LpLPApLTFp.........oSs..stoplt...A.holssp..pphplhPsHGlHuAGFhhAFl..lolVLshhshFhh.s+hpshptthlsppp.h....p.-oKL.E..t.hsou-slsE-hu.........hsDphlDILs.EDPssMlQALE-.LE......luTLs..RAD..ucLEAsRhQIsKDl..IuhLL+.sLsusGpLSsQsE++huuVa++QaLhhEpclp.EEYcRKMlALsAECsLEoR.KchEspaQREhhsh-EAE-LhK+.ssEcsshEhssLLcpLHtLEQp+Lp+pLhlppEEshAKspRQlAla........pRsELHpIFasplcsAhhpGELc.EsAKhLLpsYpchQ..-plEELMDFhQAsKRYHLu+RFuaRcaLVpslQSt-o+lpuLLSsAuuQLsplIpKhE..RAGaLsE-Qh-hLL-RAQpElhulKQKLDpDL................
//
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