GenomeNet

Database: Pfam
Entry: EZH2_WD-Binding
LinkDB: EZH2_WD-Binding
Original site: EZH2_WD-Binding 
#=GF ID   EZH2_WD-Binding
#=GF AC   PF11616.4
#=GF DE   WD repeat binding protein EZH2
#=GF AU   Pollington J
#=GF SE   pdb_2qxv
#=GF GA   25.00 25.00;
#=GF TC   43.50 42.70;
#=GF NC   20.20 17.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   17937919
#=GF RT   Structural basis of EZH2 recognition by EED. 
#=GF RA   Han Z, Xing X, Hu M, Zhang Y, Liu P, Chai J; 
#=GF RL   Structure. 2007;15:1306-1315.
#=GF DR   INTERPRO; IPR021654;
#=GF CC   This family of proteins represents Enhancer of zest homolog 2,
#=GF CC   (EZH2) a 30 residue peptide which binds to a WD-repeat domain of
#=GF CC   EED by residues 39-68. EED is a component of PRC2 complex which
#=GF CC   is involved in gene expression [1]. This interaction is required
#=GF CC   for the HMTase activity of PCR2 [1].
#=GF SQ   199
#=GS F6ZEX1_MACMU/39-68    AC F6ZEX1.1
#=GS F1QQ58_DANRE/39-68    AC F1QQ58.1
#=GS I3L7H6_PIG/39-68      AC I3L7H6.1
#=GS E1BD02_BOVIN/39-68    AC E1BD02.2
#=GS H9Z6A1_MACMU/39-68    AC H9Z6A1.1
#=GS H0X2K5_OTOGA/39-68    AC H0X2K5.1
#=GS R0KAM9_ANAPL/39-68    AC R0KAM9.1
#=GS Q571L5_MOUSE/72-101   AC Q571L5.1
#=GS G3GXG1_CRIGR/39-68    AC G3GXG1.1
#=GS F1LZH3_RAT/39-68      AC F1LZH3.2
#=GS G5B4F8_HETGA/39-68    AC G5B4F8.1
#=GS H3C8R8_TETNG/44-73    AC H3C8R8.1
#=GS H2LHB3_ORYLA/25-54    AC H2LHB3.1
#=GS H3C8Y8_TETNG/39-68    AC H3C8Y8.1
#=GS EZH2_MOUSE/39-68      AC Q61188.2
#=GS EZH2_MOUSE/39-68      DR PDB; 2QXV B; 40-68;
#=GS F6ZGV1_XENTR/40-68    AC F6ZGV1.1
#=GS H2SFW8_TAKRU/39-68    AC H2SFW8.1
#=GS W5N725_LEPOC/39-68    AC W5N725.1
#=GS H2UN45_TAKRU/25-54    AC H2UN45.1
#=GS U3K6U9_FICAL/39-68    AC U3K6U9.1
#=GS L5K0U5_PTEAL/39-68    AC L5K0U5.1
#=GS F6YRI3_MONDO/40-69    AC F6YRI3.1
#=GS E2R6Q2_CANFA/39-68    AC E2R6Q2.1
#=GS K7EIH5_HUMAN/39-68    AC K7EIH5.1
#=GS Q6GNT4_XENLA/39-68    AC Q6GNT4.1
#=GS G1LJS4_AILME/39-68    AC G1LJS4.1
#=GS Q4TEH4_TETNG/1-30     AC Q4TEH4.1
#=GS H2UN46_TAKRU/25-54    AC H2UN46.1
#=GS G1KPU3_ANOCA/44-73    AC G1KPU3.2
#=GS H3DQW4_TETNG/1-30     AC H3DQW4.1
#=GS U3EHI2_CALJA/39-68    AC U3EHI2.1
#=GS G1RM60_NOMLE/10-33    AC G1RM60.2
#=GS EZH1_PONAB/39-68      AC Q5RDS6.1
#=GS G3P0V9_GASAC/45-74    AC G3P0V9.1
#=GS G3XAL2_HUMAN/39-68    AC G3XAL2.1
#=GS K7EPC0_HUMAN/39-68    AC K7EPC0.1
#=GS Q29RB7_DANRE/45-74    AC Q29RB7.1
#=GS B7Z8K5_HUMAN/39-68    AC B7Z8K5.1
#=GS H2UN48_TAKRU/25-54    AC H2UN48.1
#=GS E1C0W5_CHICK/39-68    AC E1C0W5.2
#=GS H2UN49_TAKRU/49-78    AC H2UN49.1
#=GS H3AXZ3_LATCH/55-84    AC H3AXZ3.1
#=GS I3IY41_ORENI/25-54    AC I3IY41.1
#=GS S4S3R8_HUMAN/39-68    AC S4S3R8.1
#=GS G1MY19_MELGA/39-68    AC G1MY19.2
#=GS H3D2A7_TETNG/41-70    AC H3D2A7.1
#=GS EZH2B_XENLA/39-68     AC Q4V863.1
#=GS Q90WP4_TETNG/39-68    AC Q90WP4.1
#=GS EZH1_MOUSE/39-68      AC P70351.1
#=GS M4ACI0_XIPMA/39-68    AC M4ACI0.1
#=GS M1ELG2_MUSPF/16-45    AC M1ELG2.1
#=GS G1KPH4_ANOCA/42-71    AC G1KPH4.1
#=GS K7EM79_HUMAN/39-68    AC K7EM79.2
#=GS F6X2U8_ORNAN/52-81    AC F6X2U8.2
#=GS D5MRT8_ORYLA/58-87    AC D5MRT8.1
#=GS I3M721_SPETR/39-68    AC I3M721.1
#=GS M3WIA3_FELCA/39-68    AC M3WIA3.1
#=GS V9KET3_CALMI/39-68    AC V9KET3.1
#=GS U3ISV6_ANAPL/72-101   AC U3ISV6.1
#=GS E9PDH6_HUMAN/39-68    AC E9PDH6.1
#=GS K7ESX8_PONAB/39-68    AC K7ESX8.1
#=GS H2QD33_PANTR/42-71    AC H2QD33.1
#=GS W5NZD9_SHEEP/42-71    AC W5NZD9.1
#=GS G1MRP0_MELGA/42-71    AC G1MRP0.2
#=GS K9IZH1_DESRO/39-68    AC K9IZH1.1
#=GS H2PNY7_PONAB/39-68    AC H2PNY7.1
#=GS M7BXG7_CHEMY/100-129  AC M7BXG7.1
#=GS G7P1J2_MACFA/39-68    AC G7P1J2.1
#=GS W5KZK5_ASTMX/48-77    AC W5KZK5.1
#=GS Q8C2I5_MOUSE/39-68    AC Q8C2I5.2
#=GS K7G9J0_PELSI/54-83    AC K7G9J0.1
#=GS L9JZV6_TUPCH/39-68    AC L9JZV6.1
#=GS Q4SVV6_TETNG/1-30     AC Q4SVV6.1
#=GS K7D987_PANTR/39-68    AC K7D987.1
#=GS H3C7G6_TETNG/1-30     AC H3C7G6.1
#=GS F6WSH0_HORSE/39-68    AC F6WSH0.1
#=GS D2HN19_AILME/39-68    AC D2HN19.1
#=GS H0X1I6_OTOGA/39-68    AC H0X1I6.1
#=GS F7EPP0_CALJA/39-68    AC F7EPP0.1
#=GS B5DFE2_RAT/39-68      AC B5DFE2.1
#=GS F6VUP3_CALJA/39-68    AC F6VUP3.1
#=GS H0VLN2_CAVPO/39-68    AC H0VLN2.1
#=GS G5BDP3_HETGA/66-95    AC G5BDP3.1
#=GS I3KMB2_ORENI/39-68    AC I3KMB2.1
#=GS F1PG04_CANFA/42-71    AC F1PG04.2
#=GS L5JTD3_PTEAL/39-68    AC L5JTD3.1
#=GS E9PWK3_MOUSE/39-68    AC E9PWK3.1
#=GS D2HIU6_AILME/39-68    AC D2HIU6.1
#=GS G3NPN1_GASAC/39-68    AC G3NPN1.1
#=GS F7AIG6_MONDO/39-68    AC F7AIG6.1
#=GS H2UN47_TAKRU/25-54    AC H2UN47.1
#=GS H0YU73_TAEGU/42-71    AC H0YU73.1
#=GS F6QA88_CALJA/39-68    AC F6QA88.1
#=GS H2QVK6_PANTR/39-68    AC H2QVK6.1
#=GS Q4RDS8_TETNG/1-28     AC Q4RDS8.1
#=GS F6Q6T3_CALJA/39-68    AC F6Q6T3.1
#=GS W5N3Q8_LEPOC/177-205  AC W5N3Q8.1
#=GS F1NBM3_CHICK/39-68    AC F1NBM3.2
#=GS Q4T531_TETNG/36-65    AC Q4T531.1
#=GS H3CF02_TETNG/39-68    AC H3CF02.1
#=GS F7HE52_MACMU/79-108   AC F7HE52.1
#=GS Q4S976_TETNG/33-62    AC Q4S976.1
#=GS F6WCU8_CALJA/39-67    AC F6WCU8.1
#=GS H3AXZ4_LATCH/39-68    AC H3AXZ4.1
#=GS G3S979_GORGO/39-68    AC G3S979.1
#=GS G1NY06_MYOLU/42-71    AC G1NY06.1
#=GS G1L7Y5_AILME/39-68    AC G1L7Y5.1
#=GS F7F310_CALJA/39-68    AC F7F310.1
#=GS U6DRQ8_NEOVI/39-68    AC U6DRQ8.1
#=GS J9P0Q3_CANFA/39-68    AC J9P0Q3.1
#=GS U6DAG3_NEOVI/39-68    AC U6DAG3.1
#=GS F7EPM9_CALJA/39-68    AC F7EPM9.1
#=GS G8F640_MACFA/1-29     AC G8F640.1
#=GS G3RFW0_GORGO/42-71    AC G3RFW0.1
#=GS H0ZUE4_TAEGU/41-70    AC H0ZUE4.1
#=GS EZH2_DANRE/39-68      AC Q08BS4.1
#=GS H9Z6A2_MACMU/39-68    AC H9Z6A2.1
#=GS F7B7S5_MACMU/39-68    AC F7B7S5.1
#=GS F7BXB4_MONDO/59-88    AC F7BXB4.2
#=GS U3DM49_CALJA/39-68    AC U3DM49.1
#=GS R4GB81_ANOCA/39-68    AC R4GB81.1
#=GS Q4TFJ6_TETNG/41-70    AC Q4TFJ6.1
#=GS U3JD86_FICAL/44-73    AC U3JD86.1
#=GS S4RI70_PETMA/40-69    AC S4RI70.1
#=GS S7MMW0_MYOBR/39-68    AC S7MMW0.1
#=GS H3CEU8_TETNG/39-68    AC H3CEU8.1
#=GS G1SQ77_RABIT/44-73    AC G1SQ77.2
#=GS L9LD52_TUPCH/75-103   AC L9LD52.1
#=GS Q3U575_MOUSE/39-68    AC Q3U575.1
#=GS L8IFI9_9CETA/42-71    AC L8IFI9.1
#=GS F6WSU9_HORSE/41-70    AC F6WSU9.1
#=GS F7ANW1_ORNAN/94-123   AC F7ANW1.2
#=GS G3WZR9_SARHA/39-68    AC G3WZR9.1
#=GS Q3TZH6_MOUSE/39-68    AC Q3TZH6.1
#=GS W5QC07_SHEEP/39-68    AC W5QC07.1
#=GS G1SFW6_RABIT/39-68    AC G1SFW6.2
#=GS H3ANA1_LATCH/42-71    AC H3ANA1.1
#=GS F1S1G9_PIG/39-68      AC F1S1G9.2
#=GS M1EQM8_MUSPF/41-70    AC M1EQM8.1
#=GS H9EPI3_MACMU/39-68    AC H9EPI3.1
#=GS F8W619_DANRE/45-74    AC F8W619.1
#=GS G3HLY5_CRIGR/39-68    AC G3HLY5.1
#=GS G3SNT7_LOXAF/39-68    AC G3SNT7.1
#=GS F6YRR3_CALJA/42-71    AC F6YRR3.1
#=GS F2YMM1_HUMAN/39-68    AC F2YMM1.1
#=GS I3IY40_ORENI/57-86    AC I3IY40.1
#=GS W5LQ79_ASTMX/39-68    AC W5LQ79.1
#=GS Q5TKR5_ORYLA/38-67    AC Q5TKR5.1
#=GS F6SP16_MONDO/39-68    AC F6SP16.1
#=GS EZH2_HUMAN/39-68      AC Q15910.2
#=GS S7N8Q1_MYOBR/43-72    AC S7N8Q1.1
#=GS K7B7P7_PANTR/39-68    AC K7B7P7.1
#=GS EZH2A_XENLA/39-68     AC Q98SM3.1
#=GS M7BVS3_CHEMY/39-68    AC M7BVS3.1
#=GS Q4TF58_TETNG/1-30     AC Q4TF58.1
#=GS D3Z774_MOUSE/39-68    AC D3Z774.1
#=GS G1P1J7_MYOLU/39-68    AC G1P1J7.1
#=GS E7FFB7_DANRE/45-74    AC E7FFB7.1
#=GS V8NTZ9_OPHHA/61-90    AC V8NTZ9.1
#=GS K7GH72_PELSI/39-68    AC K7GH72.1
#=GS S9XJ27_9CETA/49-78    AC S9XJ27.1
#=GS EZH2_MACFA/39-68      AC Q4R381.1
#=GS Q6AXH7_MOUSE/39-68    AC Q6AXH7.1
#=GS K7ENP2_HUMAN/39-68    AC K7ENP2.1
#=GS M3W9W8_FELCA/2-31     AC M3W9W8.1
#=GS G3WZR8_SARHA/41-70    AC G3WZR8.1
#=GS Q4TEU5_TETNG/41-70    AC Q4TEU5.1
#=GS Q504B3_DANRE/39-68    AC Q504B3.1
#=GS G5CA03_HETGA/124-153  AC G5CA03.1
#=GS F6ZEW3_MACMU/39-68    AC F6ZEW3.1
#=GS H2UN44_TAKRU/25-54    AC H2UN44.1
#=GS X1WHS1_DANRE/39-68    AC X1WHS1.1
#=GS EZH1_BOVIN/39-68      AC A7E2Z2.2
#=GS G1QTY8_NOMLE/39-68    AC G1QTY8.2
#=GS G3T5L6_LOXAF/39-68    AC G3T5L6.1
#=GS G3PG18_GASAC/39-68    AC G3PG18.1
#=GS H0V1I5_CAVPO/42-71    AC H0V1I5.1
#=GS Q59H64_HUMAN/81-110   AC Q59H64.1
#=GS Q4T9K7_TETNG/36-65    AC Q4T9K7.1
#=GS G3QLH0_GORGO/42-71    AC G3QLH0.1
#=GS Q4TJE3_TETNG/1-30     AC Q4TJE3.1
#=GS F6SQP1_XENTR/42-71    AC F6SQP1.1
#=GS K7DDW8_PANTR/39-68    AC K7DDW8.1
#=GS M3YFG0_MUSPF/39-68    AC M3YFG0.1
#=GS G3WJT8_SARHA/39-68    AC G3WJT8.1
#=GS U3DXH6_CALJA/39-68    AC U3DXH6.1
#=GS Q4T5B4_TETNG/36-65    AC Q4T5B4.1
#=GS EZH1_HUMAN/39-68      AC Q92800.2
#=GS K9ITU8_DESRO/43-72    AC K9ITU8.1
#=GS Q6R125_HUMAN/39-68    AC Q6R125.1
#=GS G3TVT8_LOXAF/39-68    AC G3TVT8.1
#=GS EZH2_XENTR/39-68      AC Q28D84.1
#=GS I3M2Z1_SPETR/40-69    AC I3M2Z1.1
#=GS H2LD32_ORYLA/43-72    AC H2LD32.1
#=GS K7EJU6_HUMAN/39-68    AC K7EJU6.1
#=GS K7EK66_HUMAN/39-68    AC K7EK66.1
#=GS M4A3W8_XIPMA/61-90    AC M4A3W8.1
#=GS V8NEQ4_OPHHA/48-77    AC V8NEQ4.1
#=GS Q4TFL9_TETNG/1-30     AC Q4TFL9.1
F6ZEX1_MACMU/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
F1QQ58_DANRE/39-68               ..KSMFSSNRQKILERTDILNQEWKLRRIQPV.
I3L7H6_PIG/39-68                 ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
E1BD02_BOVIN/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
H9Z6A1_MACMU/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
H0X2K5_OTOGA/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
R0KAM9_ANAPL/39-68               ..KSMFNSNRQKILERTEILNQEWKQRRIQPV.
Q571L5_MOUSE/72-101              ..KTMFSSNRQKILERTETLNQEWKQRRIQPV.
G3GXG1_CRIGR/39-68               ..KTMFSSNRQKILERTETLNQEWKQRRIQPV.
F1LZH3_RAT/39-68                 ..KALYVANFAKVQEKTQLLNEEWKKLRVQPV.
G5B4F8_HETGA/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRVQPV.
H3C8R8_TETNG/44-73               ..KSMFSTDRQKIMERTDIWNQEWKTRRIQPV.
H2LHB3_ORYLA/25-54               ..KTLFSSNREKIEQQTTVLNSEWSTLKIQSI.
H3C8Y8_TETNG/39-68               ..KSMFSTDRQKIMERTDIWNQEWKTRRIQPV.
EZH2_MOUSE/39-68                 ..KTMFSSNRQKILERTETLNQEWKQRRIQPV.
#=GR EZH2_MOUSE/39-68      SS    ..X-HHHHHHHHHHHHHHHHHHHHHH------.
F6ZGV1_XENTR/40-68               mf---YVENLTKAQERAHLLNEDWKKLRVQPI.
H2SFW8_TAKRU/39-68               ..KSMFSTNRQKIVERTDILNQEWKTRRIQPV.
W5N725_LEPOC/39-68               ..KSMFNSNRQKILERTDILNQEWKLRRIQPV.
H2UN45_TAKRU/25-54               ..KALFMSNRRKIEQQTNVLNAEWSALRIQSI.
U3K6U9_FICAL/39-68               ..KSMFNSNRQKILERTEILNQEWKQRRIQPV.
L5K0U5_PTEAL/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
F6YRI3_MONDO/40-69               ..KSMFNSNRQKILERTEILNQEWKQRRIQPV.
E2R6Q2_CANFA/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
K7EIH5_HUMAN/39-68               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
Q6GNT4_XENLA/39-68               ..KSMFNTNRQKIMERTEILNQEWKQRRIQPV.
G1LJS4_AILME/39-68               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
Q4TEH4_TETNG/1-30                .r-SMFSTDRQKIMERTDIWNQEWKTRRIQPV.
H2UN46_TAKRU/25-54               ..KALFMSNRRKIEQQTNVLNAEWSALRIQSI.
G1KPU3_ANOCA/44-73               ..KALFASNYAKVQEKLDILNDDWKNLRVQPI.
H3DQW4_TETNG/1-30                .r-SMFSTDRQKIMERTDIWNQEWKTRRIQPV.
U3EHI2_CALJA/39-68               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
G1RM60_NOMLE/10-33               .k-------FAKVQEKTQILNEEWKKLRVQPV.
EZH1_PONAB/39-68                 ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
G3P0V9_GASAC/45-74               ..KTLFMSNRKKIEQQTNLLNAEWSRLRIQSI.
G3XAL2_HUMAN/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
K7EPC0_HUMAN/39-68               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
Q29RB7_DANRE/45-74               ..KALFQSNRRKIEVGTELLNEEWSKLRIQSI.
B7Z8K5_HUMAN/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
H2UN48_TAKRU/25-54               ..KALFMSNRRKIEQQTNVLNAEWSALRIQSI.
E1C0W5_CHICK/39-68               ..KSMFNSNRQKILERTEILNQEWKQRRIQPV.
H2UN49_TAKRU/49-78               ..KALFMSNRRKIEQQTNVLNAEWSALRIQSI.
H3AXZ3_LATCH/55-84               ..KSLFTANRNKVKERTEVLNEDWKKLRVQP-t
I3IY41_ORENI/25-54               ..KTLFMSNRQKIEQQTNILNTEWSKLRIQSI.
S4S3R8_HUMAN/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
G1MY19_MELGA/39-68               ..KALFVANFAKVHEKTQILNEDWKKLRVQPV.
H3D2A7_TETNG/41-70               ..KALFMSNRQKIEQQTNLLNAEWSALRIQSI.
EZH2B_XENLA/39-68                ..KSMFNTNRQKIMERTEILNQEWKQRRIQPV.
Q90WP4_TETNG/39-68               ..KSMFSTNRQKIMERTDILNQEWKTRRIQPV.
EZH1_MOUSE/39-68                 ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
M4ACI0_XIPMA/39-68               ..KSMFNSNRQKIVERTDTLNQEWKTRRIQPV.
M1ELG2_MUSPF/16-45               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
G1KPH4_ANOCA/42-71               ..KSMFNSNRQKIQERTEILNQEWKQRRIQPV.
K7EM79_HUMAN/39-68               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
F6X2U8_ORNAN/52-81               ..KSMFNSNRQKILERTEILNQEWKQRRIQPV.
D5MRT8_ORYLA/58-87               ..KTLFSSNREKIEQQTTVLNSEWSTLKIQSI.
I3M721_SPETR/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
M3WIA3_FELCA/39-68               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
V9KET3_CALMI/39-68               ..KSRFSANRQKIKEKTEILNQDWKQHRIQPV.
U3ISV6_ANAPL/72-101              ..KSMFNSNRQKILERTEILNQEWKQRRIQPV.
E9PDH6_HUMAN/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
K7ESX8_PONAB/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
H2QD33_PANTR/42-71               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
W5NZD9_SHEEP/42-71               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
G1MRP0_MELGA/42-71               ..KSMFNSNRQKILERTEILNQEWKQRRIQPV.
K9IZH1_DESRO/39-68               ..KSMFSSNRQKIVERTEILNQEWKQRRIQPV.
H2PNY7_PONAB/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
M7BXG7_CHEMY/100-129             ..KALFVANFAKVQEKTQILNEDWKKLRVQPV.
G7P1J2_MACFA/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
W5KZK5_ASTMX/48-77               ..KALFISNRQKIELRTDLLNEEWSKLRIQSI.
Q8C2I5_MOUSE/39-68               ..KTMFSSNRQKILERTETLNQEWKQRRIQPV.
K7G9J0_PELSI/54-83               ..KSMFNSNRQKILERTEILNQEWKLRRIQPV.
L9JZV6_TUPCH/39-68               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
Q4SVV6_TETNG/1-30                .r-SMFSTDRQKIMERTDIWNQEWKTRRIQPV.
K7D987_PANTR/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
H3C7G6_TETNG/1-30                .r-SMFSTDRQKIMERTDIWNQEWKTRRIQPV.
F6WSH0_HORSE/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
D2HN19_AILME/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
H0X1I6_OTOGA/39-68               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
F7EPP0_CALJA/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
B5DFE2_RAT/39-68                 ..KTMFSSNRQKILERTETLNQEWKQRRIQPV.
F6VUP3_CALJA/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
H0VLN2_CAVPO/39-68               ..KALYVANFAKVQEKTQILNEEWKKRRVQPV.
G5BDP3_HETGA/66-95               ..KALYVANFAKVQEKTQILSEEWKQRRVQPV.
I3KMB2_ORENI/39-68               ..KSMFNSNRQKIMERTDILNQEWKTRRIQPV.
F1PG04_CANFA/42-71               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
L5JTD3_PTEAL/39-68               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
E9PWK3_MOUSE/39-68               ..KTMFSSNRQKILERTETLNQEWKQRRIQPV.
D2HIU6_AILME/39-68               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
G3NPN1_GASAC/39-68               ..KSMFNTNRQKIVDRTDILNQEWKTRRIQPV.
F7AIG6_MONDO/39-68               ..KSMFNSNRQKILERTEILNQEWKQRRIQPV.
H2UN47_TAKRU/25-54               ..KALFMSNRRKIEQQTNVLNAEWSALRIQSI.
H0YU73_TAEGU/42-71               ..KSMFNSNRQKILERTEILNQEWKQRRIQPV.
F6QA88_CALJA/39-68               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
H2QVK6_PANTR/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
Q4RDS8_TETNG/1-28                ..--MFSTDRQKIMERTDIWNQEWKTRRIQPV.
F6Q6T3_CALJA/39-68               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
W5N3Q8_LEPOC/177-205             sq---FMANRSKIKEKTELLNDEWSNLRIQPI.
F1NBM3_CHICK/39-68               ..KALFVANFAKVHEKTRILNEDWKKLRVQPV.
Q4T531_TETNG/36-65               ..KSMFSTDRQKIMERTDIWNQEWKTRRIQPV.
H3CF02_TETNG/39-68               ..KSMFSTNRQKIMERTDILNQEWKTRRIQPV.
F7HE52_MACMU/79-108              ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
Q4S976_TETNG/33-62               ..KALFMSNRQKIEQQTNLLNAEWSALRIQSI.
F6WCU8_CALJA/39-67               ..-SMFSSNRQKILERTEILNQEWKQRRIQPV.
H3AXZ4_LATCH/39-68               ..KSLFTANRNKVKERTEVLNEDWKKLRVQP-t
G3S979_GORGO/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
G1NY06_MYOLU/42-71               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
G1L7Y5_AILME/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
F7F310_CALJA/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
U6DRQ8_NEOVI/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
J9P0Q3_CANFA/39-68               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
U6DAG3_NEOVI/39-68               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
F7EPM9_CALJA/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
G8F640_MACFA/1-29                ..-ALYVANFAKVQEKTQILNEEWKKLRVQPV.
G3RFW0_GORGO/42-71               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
H0ZUE4_TAEGU/41-70               ..KALFVANFAKVHEKTQILNEDWKKLRVQPV.
EZH2_DANRE/39-68                 ..KSMFSSNRQKILERTDILNQEWKLRRIQPV.
H9Z6A2_MACMU/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
F7B7S5_MACMU/39-68               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
F7BXB4_MONDO/59-88               ..KALFVANFAKVQEKTQILNEDWKRLRIQPV.
U3DM49_CALJA/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
R4GB81_ANOCA/39-68               ..KSMFNSNRQKIQERTEILNQEWKQRRIQPV.
Q4TFJ6_TETNG/41-70               ..KSMFSTNRQKIMERTDILNQEWKTRRIQPV.
U3JD86_FICAL/44-73               ..KALFVANFAKVHEKTQILNEDWKKLRVQPV.
S4RI70_PETMA/40-69               ..KSAFLANRHKIKDRTDVLNEEWKQRRVQPI.
S7MMW0_MYOBR/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
H3CEU8_TETNG/39-68               ..KSMFSTDRQKIMERTDIWNQEWKTRRIQPV.
G1SQ77_RABIT/44-73               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
L9LD52_TUPCH/75-103              .r--MFSSNRQKILERTEILNQEWKQRRIQPV.
Q3U575_MOUSE/39-68               ..KTMFSSNRQKILERTETLNQEWKQRRIQPV.
L8IFI9_9CETA/42-71               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
F6WSU9_HORSE/41-70               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
F7ANW1_ORNAN/94-123              ..KALFVANLAKVQEKTQLLNEAWKELRVQPV.
G3WZR9_SARHA/39-68               ..KSMFNSNRQKILERTEILNQEWKQRRIQPV.
Q3TZH6_MOUSE/39-68               ..KTMFSSNRQKILERTETLNQEWKQRRIQH-v
W5QC07_SHEEP/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
G1SFW6_RABIT/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
H3ANA1_LATCH/42-71               ..KSMFNSNRQKIQEKTEILNQEWKQRRIQPV.
F1S1G9_PIG/39-68                 ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
M1EQM8_MUSPF/41-70               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
H9EPI3_MACMU/39-68               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
F8W619_DANRE/45-74               ..KALFQSNRRKIEVGTELLNEEWSKLRIQSI.
G3HLY5_CRIGR/39-68               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
G3SNT7_LOXAF/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
F6YRR3_CALJA/42-71               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
F2YMM1_HUMAN/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
I3IY40_ORENI/57-86               ..KTLFMSNRQKIEQQTNILNTEWSKLRIQSI.
W5LQ79_ASTMX/39-68               ..KSMFNSNRQKILERTDILNQEWKLRRIQPV.
Q5TKR5_ORYLA/38-67               ..KGMFNSNRQKIMERTDILNQEWKTRRIQPI.
F6SP16_MONDO/39-68               ..KSMFNSNRQKILERTEILNQEWKQRRIQPV.
EZH2_HUMAN/39-68                 ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
S7N8Q1_MYOBR/43-72               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
K7B7P7_PANTR/39-68               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
EZH2A_XENLA/39-68                ..KSMFNTNRQKIMERTEILNQEWKQRRIQPV.
M7BVS3_CHEMY/39-68               ..KSMFNSNRQKILERTEILNQEWKQRRIQPV.
Q4TF58_TETNG/1-30                .r-SMFSTNRQKIMERTDILNQEWKTRRIQPV.
D3Z774_MOUSE/39-68               ..KTMFSSNRQKILERTETLNQEWKQRRIQPV.
G1P1J7_MYOLU/39-68               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
E7FFB7_DANRE/45-74               ..KALFQSNRRKIEVGTELLNEEWSKLRIQSI.
V8NTZ9_OPHHA/61-90               ..KNLFVSNFTKIQEKINILNDDWKKLRVQPI.
K7GH72_PELSI/39-68               ..KALFVTNFAKVQEKTQILNEEWKNLRVQPV.
S9XJ27_9CETA/49-78               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
EZH2_MACFA/39-68                 ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
Q6AXH7_MOUSE/39-68               ..KTMFSSNRQKILERTETLNQEWKQRRIQPV.
K7ENP2_HUMAN/39-68               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
M3W9W8_FELCA/2-31                ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
G3WZR8_SARHA/41-70               ..KSMFNSNRQKILERTEILNQEWKQRRIQPV.
Q4TEU5_TETNG/41-70               ..KSMFSTDRQKIMERTDIWNQEWKTRRIQPV.
Q504B3_DANRE/39-68               ..KSMFSSNRQKILERTDILNQEWKLRRIQPV.
G5CA03_HETGA/124-153             ..KALYVANFAKVQEKTQILNEEWKQRRVQPV.
F6ZEW3_MACMU/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
H2UN44_TAKRU/25-54               ..KALFMSNRRKIEQQTNVLNAEWSALRIQSI.
X1WHS1_DANRE/39-68               ..KSMFSSNRQKILERTDILNQEWKLRRIQPV.
EZH1_BOVIN/39-68                 ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
G1QTY8_NOMLE/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
G3T5L6_LOXAF/39-68               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
G3PG18_GASAC/39-68               ..KSMFNTNRQKIVDRTDILNQEWKTRRIQPV.
H0V1I5_CAVPO/42-71               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
Q59H64_HUMAN/81-110              ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
Q4T9K7_TETNG/36-65               ..KSMFSTNRQKIMERTDILNQEWKTRRIQPV.
G3QLH0_GORGO/42-71               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
Q4TJE3_TETNG/1-30                .q-SMLSTDRQKIMERTDIWNQEWKTRRIQPV.
F6SQP1_XENTR/42-71               ..KSMFNTNRQKIMERTEILNQEWKQRRIQPV.
K7DDW8_PANTR/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
M3YFG0_MUSPF/39-68               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
G3WJT8_SARHA/39-68               ..KALFVANFAKVQEKTQILNEDWKKLRIQPV.
U3DXH6_CALJA/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
Q4T5B4_TETNG/36-65               ..KSMFSTDRQKIMERTDIWNQEWKTRRIQPV.
EZH1_HUMAN/39-68                 ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
K9ITU8_DESRO/43-72               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
Q6R125_HUMAN/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
G3TVT8_LOXAF/39-68               ..KSMFSSNRQKILERTEILNQEWKQRRIQPV.
EZH2_XENTR/39-68                 ..KSMFNTNRQKIMERTEILNQEWKQRRIQPV.
I3M2Z1_SPETR/40-69               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
H2LD32_ORYLA/43-72               ..KGMFNSNRQKIMERTDILNQEWKTRRIQPI.
K7EJU6_HUMAN/39-68               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
K7EK66_HUMAN/39-68               ..KALYVANFAKVQEKTQILNEEWKKLRVQPV.
M4A3W8_XIPMA/61-90               ..KSLFMSNRQKIELQTNLLNTEWSKLRIQAI.
V8NEQ4_OPHHA/48-77               ..KSMFNYNRQKIQERTEILNQEWKQRRIQPV.
Q4TFL9_TETNG/1-30                .r-SMFSTDRQKIMERTDIWNQEWKTRRSQPV.
#=GC SS_cons                     ..X-HHHHHHHHHHHHHHHHHHHHHH------.
#=GC seq_cons                    ..KohFsoNRQKIhERT-ILNpEWKpRRIQPV.
//
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