GenomeNet

Database: Pfam
Entry: EcoRII-C
LinkDB: EcoRII-C
Original site: EcoRII-C 
#=GF ID   EcoRII-C
#=GF AC   PF09019.9
#=GF DE   EcoRII C terminal
#=GF AU   Mistry J, Sammut SJ
#=GF SE   pdb_1na6
#=GF GA   20.30 20.30;
#=GF TC   20.40 21.00;
#=GF NC   20.20 19.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   R.EcoRII
#=GF RN   [1]
#=GF RM   14659759
#=GF RT   Crystal structure of type IIE restriction endonuclease EcoRII
#=GF RT   reveals an autoinhibition mechanism by a novel effector-binding
#=GF RT   fold. 
#=GF RA   Zhou XE, Wang Y, Reuter M, Mucke M, Kruger DH, Meehan EJ, Chen
#=GF RA   L; 
#=GF RL   J Mol Biol. 2004;335:307-319.
#=GF DR   INTERPRO; IPR015109;
#=GF CC   The C-terminal catalytic domain of the Restriction Endonuclease
#=GF CC   EcoRII has a restriction endonuclease-like fold with a central
#=GF CC   five-stranded mixed beta-sheet surrounded on both sides by
#=GF CC   alpha-helices. It cleaves DNA specifically at single 5' CCWGG
#=GF CC   sites [1].
#=GF SQ   52
#=GS J9ZE30_LEPFM/235-402      AC J9ZE30.1
#=GS A8G987_SERP5/232-396      AC A8G987.1
#=GS H3KI73_9BURK/146-317      AC H3KI73.1
#=GS E7GQT1_CLOSY/217-382      AC E7GQT1.1
#=GS A0A0F7KX15_9SPHN/228-396  AC A0A0F7KX15.1
#=GS H6LJ76_ACEWD/228-392      AC H6LJ76.1
#=GS C4ZAA8_AGARV/216-381      AC C4ZAA8.1
#=GS G2IUA0_PSEUL/237-408      AC G2IUA0.1
#=GS G4E5I7_9GAMM/236-400      AC G4E5I7.1
#=GS A0A0G2AS96_9BACT/229-393  AC A0A0G2AS96.1
#=GS A0A0N1BB99_9PROT/168-329  AC A0A0N1BB99.1
#=GS C5BFF1_EDWI9/227-391      AC C5BFF1.2
#=GS A6H1I6_FLAPJ/118-283      AC A6H1I6.1
#=GS A9MS72_SALAR/227-391      AC A9MS72.1
#=GS G9RPY3_9FIRM/217-382      AC G9RPY3.1
#=GS D5QBX9_KOMHA/229-397      AC D5QBX9.1
#=GS Q727L4_DESVH/225-389      AC Q727L4.1
#=GS Q0AK57_MARMM/222-391      AC Q0AK57.1
#=GS K2D2K9_9BACT/236-399      AC K2D2K9.1
#=GS D3VAD7_XENNA/233-403      AC D3VAD7.1
#=GS J1Q9P8_9ENTR/234-404      AC J1Q9P8.1
#=GS F2NVD3_TRES6/217-382      AC F2NVD3.1
#=GS K0IIH6_NITGG/84-247       AC K0IIH6.1
#=GS W8VCB3_YEREN/4-45         AC W8VCB3.1
#=GS B3EB39_GEOLS/231-395      AC B3EB39.1
#=GS R5VI29_9PORP/92-165       AC R5VI29.1
#=GS T1I3N5_RHOPR/237-407      AC T1I3N5.1
#=GS A1WU40_HALHL/231-398      AC A1WU40.1
#=GS A0A0A0Z842_9ENTR/227-391  AC A0A0A0Z842.1
#=GS A0A0G1YD81_9BACT/229-393  AC A0A0G1YD81.1
#=GS A8AM36_CITK8/227-391      AC A8AM36.1
#=GS A1A2Y0_BIFAA/83-248       AC A1A2Y0.1
#=GS C4K5I7_HAMD5/230-401      AC C4K5I7.1
#=GS A0A0E9N2R3_9SPHI/228-395  AC A0A0E9N2R3.1
#=GS B6GA13_9ACTN/228-394      AC B6GA13.1
#=GS A0A0C9NG33_SPHPI/231-394  AC A0A0C9NG33.1
#=GS R6ETE5_9FIRM/218-383      AC R6ETE5.1
#=GS R5GVJ7_9BACT/218-381      AC R5GVJ7.1
#=GS H2CIA7_9LEPT/227-402      AC H2CIA7.1
#=GS Q9JZ51_NEIMB/218-386      AC Q9JZ51.1
#=GS E2ZD30_9FIRM/107-272      AC E2ZD30.1
#=GS A4ABD8_9GAMM/233-401      AC A4ABD8.1
#=GS L0EBE4_THECK/231-399      AC L0EBE4.1
#=GS H2ISN5_RAHAC/232-396      AC H2ISN5.1
#=GS A0A0F7HPZ5_9STAP/208-371  AC A0A0F7HPZ5.1
#=GS A5FU96_ACICJ/233-400      AC A5FU96.1
#=GS Q8G4B6_BIFLO/235-405      AC Q8G4B6.1
#=GS Q8KAN4_CHLTE/1-74         AC Q8KAN4.1
#=GS E8SGE7_STAPH/83-249       AC E8SGE7.1
#=GS J0N5F7_9CLOT/217-382      AC J0N5F7.1
#=GS R7B2S4_9CLOT/217-382      AC R7B2S4.1
#=GS A0A0F5EYK8_AVIPA/12-126   AC A0A0F5EYK8.1
J9ZE30_LEPFM/235-402                 .....................FQSVEEAIELPVIRRGFS.......-SVSEFVD.RAQTI....LQRRKSRSGKSLELHLKEIFLEDGLsegrDFSCQA........ESEPGKRPDFIFPSEAAYR............DPSFPSEKLRMLAAKTTCKDRWRQILNEADR..I..Q..V..KHLLTLQDG.VSENQFREMSESGVQLVVPKSL.HDS.YPP.NIRQNLLTLKDFI........................
A8G987_SERP5/232-396                 .....................FRQIEEIHVLDKIKKGFN.......-SVEEFIE.LANSV....SNRRKSRSGKSLEMHLEKIFLANGL...tTFTTQS........ITEGKKKPDFLFPSGIEYH............NPAYPAENLRMLAVKTTCKDRWRQAINEANR..I..N..N..IHLFTLQEG.VSANQFQEMKDAGVTLVVPEPL.HKK.YPE.KIRSELVSLSDFI........................
H3KI73_9BURK/146-317                 leprllrqalrrkfagerslq------------LEKMTA.......RQFDDILE.ATSST....LSSLKTRSGCALHHHVAHILSERGV....SYTERG........DADDAQPAGFILSVADAMS............EADHPAER--FLASKPELKDDWRKVFTDIED..I..R..V..KYLLTLDCS.ISEASLEDMTAAGVRLVVPQPY.RQT.YPA.SLQRRIITFADFI........................
E7GQT1_CLOSY/217-382                 .....................FRELEYARYGDIIKKGFQ.......-SVDEFVK.VANMV....LNRRKSRAGKSLEHHLAAIFDGNKI....EYTAQA........VTEGNKKPDFIFPSQTAYH............DTRFSIDYLVSLAAKTTCKDRWRQVLNEADR..L..R..DksKYLCTLQQG.ISGAQMDEMQAENVVLIVPRPY.IKA.YPA.DRQERIWTLSRFV........................
A0A0F7KX15_9SPHN/228-396             .....................FRRLERRIVTARIGDGFRap...dgADVDGFLS.FSLSV....QNRRKARAGQALENHLEAVFGAQGI....CYVRGA........ETENRNKPDFLFPGQEEYR............DPDFPAARLTMLGAKSTLKDRWRQVLSEAVR..I..E..E..KHLLTLEPG.ISENQTDEMQAKRLQLVVPQRL.HNT.YRL.TQQAWLMDVTSFL........................
H6LJ76_ACEWD/228-392                 .....................FRTLEKHLIRERLKTGFE.......DDVDAFIS.FSLSV....QNRRKSRVGQALENHVECLLQNRGI....QYDRTK........ITENKSKPDFIFPSISDYH............NRDFSVERLTMLGAKTTCKDRWRQVLPEAER..I..K..H..KHLLTLEAA.ISENQTEEMIAHNLQLVVPKRL.HQT.YSA.KQQAWLIDVNEF-f.......................
C4ZAA8_AGARV/216-381                 .....................FRALEEYRYGDIVRCGFP.......-SVEEFVS.VANSV....LNRRKSRAGKSLEHHLEAIFVANEI....IYDAQP........VTEGKKKPDFLFPSAVAYR............DLTYPVSKLATLAAKTTCKDRWRQILNEANR..L..KdeN..KFLCTLQQG.VSPMQMDEMEAEKVILVVPKPY.ISC.YPR.DRQDRIWTISRFV........................
G2IUA0_PSEUL/237-408                 .....................FRIYERHLVQDRLRAGFGd....hgDDVDEFIS.FSLSV....QNRRKSRVGHAFEGHLDHLFRLHKL....KFQQGRgk....ghVTENNAKPDFLFPSFTDYN............NPDFPTDNLIMLGAKTTCKDRWRQVLSEAAR..I..P..S..KHLVTLEAA.ISEAQTDEMASHNLKLVIPATV.HAT.YSE.KQKHWLLDLQEFI........................
G4E5I7_9GAMM/236-400                 .....................FRTLEKQIIGERLAQGFD.......GDVDGFIS.FSLSV....QNRRKSRAGLAFENHLEILFEECGV....RYARTP........VTEQKSKPDFIFPGVKEYY............DKSFDSLRLTMLGVKSSCKDRWRQVLAEADR..I..E..K..KHLLTLETA.ISKSQTDEMQSKKLQLVLPRGL.HNT.YSA.EQQSWLMDVSGF-t.......................
A0A0G2AS96_9BACT/229-393             .....................FRALERHIVRDRISKGFG.......ADVDSFIS.FSLSV....QNRRKARMGQSLENHLAHLFTESGI....RYSKNK........NTEGKKKPDFLFPGVEQYH............DPKFPAESLTMLGAKSSCKERWRQVLSEAGR..I..T..E..KHLITLEPG.ISVDQTKEMQESSLQLVVPDSI.HKT.YSD.RQRDWLMSVKEFI........................
A0A0N1BB99_9PROT/168-329             .........gdsqidskravm---------------ACI.......ENFDELYR.VFLSA....SQARASRAGGSFETVVARTLNAGGI....PFAAQN........MFD-GSKPDFVLPNASTYE............NDTLRGDHALILTLKTTLRERWKQVVSESKN..C..-..P..IYLGTLDEN.ITSATLDKLSDHSIFLVVPERF.KASvYTEyANRESVISYRDF-f.......................
C5BFF1_EDWI9/227-391                 .....................FLQVEELHVLSVIKTGFS.......-SVDAFIS.LANSV....SNRRKSRSGKSLELHLENIFYEYGL...tEFETQA........VTEGNKKPDFLFPSAKAYH............DDSWPPQKLRMLAVKTTCKDRWRQILNEADR..I..Q..D..IYLFTLQEG.VSITQFREMQEERVRLVVPEKL.HEK.YPA.EIRGNLISLNDFI........................
A6H1I6_FLAPJ/118-283                 ..etvkeicgeyagrvfpyiy------------------.......-------R.LSLSN....TQSRRSRAGKSFEAIIYKIYENLGY....EYDSQSkvgrktfdTLGLGKKVDSILPNIKCYA............ERR---NKTIIGTMKTSLRERWQEVAEEIERtkI..P..E..IHLLTADES.IPKSKAQEMANHNIIVVTYEWV.ANS.VAL.KSMKNIISFEEY-l.......................
A9MS72_SALAR/227-391                 .....................FLLVEEMHVLGMVQSGFD.......-SVNEFIA.LANSV....SNRRKSRAGKSLELHLEQLFNEHGL...tTFETQA........VTEGNKKPDFLFPSAQAYH............DETFPEQKLRMLAVKTTCKDRWRQILNEADR..I..Q..D..IYLFTLQEG.VSVAQFQEMQQERVRLVVPNSL.HDK.YPK.TIREYLISLETFI........................
G9RPY3_9FIRM/217-382                 .....................FRALEYARYGAMITGGFA.......-TVEDFIT.TANQV....LNRRKSRAGKSLEHHLSALFSGNGL....QFEEQA........VTEGNKKPDFLFPSQEAYH............TATFPTEKLISLAAKTTCKDRWRQVINEADR..L..RgrP..KYLCTLQQG.ISTAQLDEMAAEQIILVVPKPY.IAS.YPR.DRQDRVWTLRHFV........................
D5QBX9_KOMHA/229-397                 .....................FRRLERRVVAEKINGGFQca...egADVDGFLA.FSLSV....QNRRKARAGSALENHLEAVFQANGI....RYARGA........ETENRNKPDFLFPGKAAYA............DPIFSADRLTMLGSKSTLKDRWRQVLSEAVR..I..R..K..KHLLTLEPG.ISENQTDEMRVKELQLILPQKL.HAT.FRP.SQQAWLMNVREFI........................
Q727L4_DESVH/225-389                 .....................FRMFERHLVAQRLREGFG.......EDVDAFTG.YALSV....LNRRKARAGKALENHVEQVLKDWGV....PYTREC........RTENNSKPDFIFPGCSEYH............QTNFPQDQLRMLAVKSTCKDRWRQVLAEAAR..V..S..R..KHLLTLEPG.ISVQQTTEMVDHAVQLVIPRGI.QSS.FQD.AQREELISLGEFV........................
Q0AK57_MARMM/222-391                 .....................FRALERGIVGDRLMLGFLds..rgePDVDAFLK.FSLSV....QNRRKSRAGHALMNHFSKILRAFEI....PFTPEA........TTEKKGAADFLFPSEAAYA............DPGFPSANLRMVAAKTSCKDRWRQVLAEADR..I..K..P..KHLLTLQPK.ISLAQTTEMTDQGIILTLPSPI.HSS.FQD.DQRASLLTVADL-l.......................
K2D2K9_9BACT/236-399                 .....................FELIEQAEVLPVIKSGFT.......-SVEEFIK.YSHSV....SNRRKSRTGTSLELNLEVLFNDEKL....QFETQV........RTENRKTADFLFPSGKAYK............DLSFPEHHLQMLAAKTCCKDRWRQVISEADR..I..K..T..KHLFTLQEG.ISGNQLQEMKDNNVQLIIPGSY.KNM.FPS.VWRDSLLSLQDFV........................
D3VAD7_XENNA/233-403                 .....................FKVYERHEVAKKLSQGFGe....ngNDVDEFIH.FSLSI....QNRRKSRAGFAFENHLNQLFLLHNL....QFQQGSa.....knITENKSKPDFLFPCFSAYH............DKFFPQENLRLLGAKTTCKDRWRQVLAEGDR..V..V..R..KHLITMQPG.ISEQQLAEMKNKSLQLVVPESV.QSL.YPV.SYANDLQNVMEFI........................
J1Q9P8_9ENTR/234-404                 .....................FRTYERYLVSNRLRHGFGd....dgSDVDTFID.FSLSV....HNRRKSRMGFSFENHLGHLFNLHGL....KFEKGSs.....kkTTENKSKPDFLFPSFDAYH............DKNYDAEKLILLGAKTTCKDRWRQVLAEGDR..L..K..T..KYLVTIQPG.ISKAQLTEMRDKHLNLIVPFPL.WET.YPH.DVHQELMSVKEFI........................
F2NVD3_TRES6/217-382                 .....................FRAIEHDRYGSLIKNGFS.......-DVEKFIE.LANQV....LNRRKSRAGKSLEHHLSSLFKGNSI....TFTPQA........ITEGNKKPDFIFPSIEAYH............DTSFSVVKLASLAAKTTCKDRWRQVLNEADR..L..RsqN..KFLCTLQQG.ISSAQLEEMKSEKVVLVVPERY.IKT.YPE.KYQQDIWTVKKFI........................
K0IIH6_NITGG/84-247                  ....peieantknqkefvsel------------------.......--LDIFMP.VAVSFefrtSQMRKSRAGTTFEHITVFLLQKCGI....KCERTAk......sVRKKMNRMDIVIPNQEVAL............K---KPDQAKFLSCKHTLRERWKQALPEKNR..N..W..V..MYLITMDDD.IPDQKAKEINDHNLIVYVKDQV.KAK.SYL.AKKDW--------irklsdl.................
W8VCB3_YEREN/4-45                    .................sflt------------------.......--------.-----....-------------------------....------........-------------------............-------------------------------..-..-..-..---------.---IQTDEMASKCLQFVLPRGL.HQT.YTP.AQQTWLMDVATF-t.......................
B3EB39_GEOLS/231-395                 .....................FRTLERHIIGDRLQVGFV.......DDVDGFVT.YSLSV....QNRRKSRAGSSLENHLEVIFNAQGI....QYTRTP........VTENNEKPDFIFPDIIHYR............DPDFDVSKLTMLGVKSTCKDRWRQILSEADR..I..K..S..KHLLTLEPG.ISENQTNQMKRSNLQLVVPSAL.QRT.YKT.EQQTWLLTFDDFI........................
R5VI29_9PORP/92-165                  .....................FKALEIKIYGDKLKSSFN.......-DMDDLIG.FSNTM....LNRRKSGAGKSLEHHLAQIFTNAGL....RFETQE........MTEGKKKPDFLFP------............-------------------------------..-..-..-..---------.----------------------.---.---.-------------........................
T1I3N5_RHOPR/237-407                 .....................FRTLERYLIADKLSKGFSpkg.ngiVDTDGFLQ.FSLSV....QNRRKSRVGLALENHLEIIFKENGI....RYSRGV........VTENRCKPDFLFPSIVEYR............DPDFAHFNLTMLGVKSTCKDRWRQILSEASR..I..P..A..KHLLTLQPS.ISENQTKEMATENVQLVVPALL.HST.YSS.EQQKWLKDLNTFI........................
A1WU40_HALHL/231-398                 .....................FRAYEREIVQERLERGFA.......GDVDEFIR.FSLSV....HNRRKSRVGHAFENHLTELFERHGL....RFEKGGv.....nrVTENKSKPDFLFPGFTEYH............DPQFPNSRLFLLGAKTTCKERWRQVLAEGER..L..K..R..KHLATLEPG.ISRTHTDEMSAHGLQLVVPLPI.HAT.YSE.TQRMKIMGIQDFI........................
A0A0A0Z842_9ENTR/227-391             .....................FLLVEELHVLDIIRKGFG.......-SVDEFIA.LANSV....SNRRKSRAGKSLELHLEHLFIEHGL...rHFATQA........ITEGNKKPDFLFPSAGAYH............DTEFPVENLRMLAVKTTCKDRWRQILNEADK..I..H..Q..VHLFTLQEG.VSLAQYREMRESGVRLVVPSSL.HKK.YPE.AVRAELMTLGAFI........................
A0A0G1YD81_9BACT/229-393             .....................FRALERHIVRDRISKGFG.......ADVDSFIS.FSLSV....QNRRKARMGQSLENHLAHLFTESGI....RYSKNK........NTEGKKKPDFLFPGVEQYH............DPKFPAESLTMLGAKSSCKERWRQVLSEAGR..I..T..E..KHLITLEPG.ISVDQTKEMQESSLQLVVPDSI.HKT.YSD.RQRDWLMSVKEFI........................
A8AM36_CITK8/227-391                 .....................FLLVEEMHVLGIVQSGFG.......-SVNEFIA.LANSV....SNRRKSRAGKSLELHLEQLFNEHGL...kTFETQA........VTEGNKKPDFLFPSAQAYH............DEAFPEQKLRMLAVKTTCKDRWRQILNEADR..I..Q..D..IYLFTLQEG.VSVAQFQEMQQERVRLVVPSSL.HDK.YPK.AIREYLISLETFI........................
A1A2Y0_BIFAA/83-248                  ...fkgmeavdaikkfvsdyp------------------.......---QHIYE.LTLSN....TQSRRSRAGKEFEAIIEMMLIGASI....PTDSQGnvgkqffaQHHLGKLVDFVTPGAIQYS............---IDKQRTVLISAKTTLRERWQEVPEEVTR..TgaP..R..MYLATLDSD.ITENTLNVLYESNITIVTTKEN.RSH.YTN.---PRVMTFEEMI........................
C4K5I7_HAMD5/230-401                 .....................FRTLESYLIADRLSQGFSgkasvaaVDVDGFLS.FSLSV....QNRRKSRVGLALENHLEVLFSENGL....RYTRTA........VTENKAKPDFLFPGVTEYH............NPAFDPLKLTMPGVKSTCKDRWRQVLAEADR..I..D..N..KHLLTLETE.ISTHQTDEMAAKRLQLVLPRSL.YQT.YTP.SQQTWLIDVASF-t.......................
A0A0E9N2R3_9SPHI/228-395             .....................FKALEAKIVSAKLKNGFGl....vsSEVEEFIS.FSLSV....QNRRKSRAGHAFENNLAKIFEVNNI....YFAKGA........TTERSNKPDFLFPGLSEYQ............NLTFPADMLTMLGVKTTAKDRWRQILMEADR..V..S..L..KHLITLEPS.ISKNQTDEMIAQKIQLILPEPL.LST.YTQ.SQQQTLITLSQFL........................
B6GA13_9ACTN/228-394                 .....................FKVFERHLLERDLAPYLNg.....vLDVDGILK.TTMST....FQRRKSRAGTAFEHQLEFLFKGRGI....RYSSQP........YTEGKSKPDFIFPSIECYR............DDAFPPDCLTMLGAKTTIKERWRQVLEEANR..I..A..H..KHLITLEPA.VSVDYTNAMRASSLQLVVPHEL.FAT.YTT.SQQEWLMDVASF-c.......................
A0A0C9NG33_SPHPI/231-394             .....................FRTLERHLIGDRLQAGFG.......-EIDDFLQ.FSLSV....QNRRKSRAGSALENHLEHMFATLGI....VGDRTP........VTEGKAKPDFLFPGTKAYQ............DENFPPELLTMLGVKSTCKDRWRQVLAEADK..I..P..D..KHLLTLEPS.ISANQTDEMQQRRLQLIVPSGL.HHT.YTA.AQQRWLMSVGNLI........................
R6ETE5_9FIRM/218-383                 .....................FRAIEHARYGETISRGFD.......-SVDSFIT.MANMV....LNRRKSRAGKSLEHHLSAIFDGNSI....AYSAQA........VTEGNKKPDFIFPSQEAYH............NATFPTDRLISLAAKTTCKDRWRQVINEADR..L..R..DrpKYLCTLQQG.ISPAQMDEMQSENVILVVPKPY.ISS.YPA.DRQNRIWTLSQFV........................
R5GVJ7_9BACT/218-381                 .....................FRNFEDKFYRDAYQRPFS.......-CCQDLID.FANSI....LNRRKSRAGKSLEHHLATIFSANRL....HYEQQI........VTEGNKRPDFIFPSGKAYH............DIVFPTKDLVFLGAKTTCKDRWRQILNEANR..I..K..D..KYLFTLQQG.ISKNQLSEMKSEHVTLVVPEAY.RQS.FPE.EFRANIKSLSSFI........................
H2CIA7_9LEPT/227-402                 .....................FRYFERKHYQPLIEEGFQ.......-RIDDFLS.LSLEI....HNRRKSRAGNSLEIHLKYVFDRSRI....ACAHGV........ITSDQRRPDFLFPSLDAYEsyrvrhreaennVSSSDAEGVFFLAAKTTCKDRWRQILTEAPG..V..N..R..RYLFTLQQA.ISKAQLDEMSDEGVTVVMPESY.RRK.FDA.QNRGRIMSLAEFI........................
Q9JZ51_NEIMB/218-386                 .....................FSIFEKREF-EIIKSKIT.......-DLDSFIN.FAHSF....TNRRKARAGKSLELHLSRIFDEFSL....KFETQA........KTEGKKKPDFLFPGSEEYHamd......esgNFIFQTEKLTMLGSKTTCKDRWRQVLNEADR..I..P..H..KHLFTLQEG.ISDTQIQEMSDENLTLVVPKES.VKT.FGT.FGKTHVLTLENFI........................
E2ZD30_9FIRM/107-272                 .....................FRAIEHARYGDVVAGGFA.......-SVDDFVI.MANRV....LNRRKSRAGKSLEHHLSAIFDENRI....QYAAQA........VTEGNKKPDFLFPSEEAYH............DMTFEIEKLCTLAAKTTCKDRWRQILNEADR..L..R..DesKYLCTMQQG.ISAAQMDEMQAEKVILVVPKAY.HSA.YPK.EKRDRIWTLGRFV........................
A4ABD8_9GAMM/233-401                 .....................FRRLEKRVVAERITAGFVqd...gdIDVDGFIS.FSLGV....QNRRKSRMGHSFENHLKAVFTAHEI....RYDSQV........VTEKGKKPDFVFPGSSQYF............DDRFQAELLTMLAAKSTCKDRWPQILPEAER..I..E..R..KHLITLEPG.ISRSQTDTMRASNVQLIIPQGL.HSS.YAN.DQRSWLWNVENFL........................
L0EBE4_THECK/231-399                 .....................FKRLERHIISKKLEHGFRdn...dsIDVDGFLQ.FSLSV....HNRRKSRVGYALENHLEEIFKIHEI....TYSRTA........ITENKSRPDFLFPGADHYH............DPAFPSERLTMLGVKSTCKDRWRQVLAEADR..I..K..S..KHLLTLEPG.ISENQTDEMQASNLQLVLPQPL.HET.YKP.RQRCWLINLSDFI........................
H2ISN5_RAHAC/232-396                 .....................FLHIEEFHVLHKIKDGFN.......-SVNEFIA.LANSV....SNRRKSRAGKSLELHLEVIFKDNNL...lDFSTQC........VTEGNKKPDFIFPSGQAYH............DFNYPEEKLRMLAVKTTCKDRWRQAINEADK..I..K..K..VHLFTLQEG.VSVNQFNEMKEAGIILVVPKPL.HEK.YPK.DIRMELVTLEDFI........................
A0A0F7HPZ5_9STAP/208-371             .....................FKMLEKQIYKEYITEPFN.......-ELQPLLD.FANSA....LNRRKSRAGRSLEHHVNYIFKKYKL....PFDNPG........KTEGRKKPDFLLPSTEDYQ............NSEFPAENLILVGAKTTCKDRWRQVLSEGER..V..E..R..KHLITLQQG.ISENQLEEMEAANLQLVVPKPY.HKQ.YPK.SFKDKIWTVQQFI........................
A5FU96_ACICJ/233-400                 .....................FLSVEEAVYLPRIRQGFS.......-AIGDFLS.LAQTI....LQSRKTRSGTSLELHVREIMTEEGLladtSFTYRP........VIENGKRPDFLFPSKAAYD............NPAFPAERLRMLAAKTTCKDRWRQVLNEADR..I..A..T..KHLLTLQEG.VSEGQFREMSEAGVRLVVPAEL.HRS.YPA.SVRPHLVTFENFI........................
Q8G4B6_BIFLO/235-405                 .....................FKLYERAVIQHDYDAAPFvs..dgvIDVDSFTS.FYTSV....RNRRMSRAGKVLEIHIAHILDARGI....EYEAQA........KTENGKKPDFLFPSQAAYE............DPAFPEEQLRMLASKTSIKDRFRQVADEANR..I..R..D..KHLFTLTPGdVTHPKLAQLDELHIHLVMPKVV.KES.YDD.LIQGETMTFSRFI........................
Q8KAN4_CHLTE/1-74                    .....................------------------.......--------.-----....-------------------------....------........-------------------............----------MLAVKTTCKDRWRQVLNEANR..I..G..K..KHLLTVQQG.ISLNQFREMRAHDVQLVVPADI.IKL.YHK.DIRSEIMTLEGFL........................
E8SGE7_STAPH/83-249                  ....lgldniesikwfvenfp------------------.......---DHIYR.LSLSN....TQSRRSRAGKEFEIIIELILMGANI....PFDTQGsigsgvfeSSELAKLVDCVSPGALEYK............---LDKRNTSLISAKTTLRERWQEVGDEMAR..T..KarE..MYLVTLDEN.ITSQTMKLISANNIVIVTTNSIlNDN.YKK.M------------hgiisveeml..............
J0N5F7_9CLOT/217-382                 .....................FREIEHVRYGEVITQGFA.......-SVEDFIS.MANQV....LNRRKSRAGKSLEHHLAAIFNGNDI....SYKAQA........VTEGNKRPDFIFPSEEAYR............DFDFSNDRLISLAAKTTCKDRWRQVINEADR..LrgK..A..KYLCTLQQG.ISAAQMDEMQAEQVILVVPKPY.IST.FPK.DRQNRIWTVRKFV........................
R7B2S4_9CLOT/217-382                 .....................FRALEYARYGDIITKGFQ.......-SVDEFVR.VANVV....LNRRKSRAGKSLEHHLSAIFDGNGI....EYSSQA........VTEGNKKPDFLFPSQEAYH............DYDFSTDYIISLAAKTTCKDRWRQVLNEADR..L..R..DkpKYLCTLQQG.ISGAQMDEMQAENVILVVPKPY.IAT.YPK.DRRDRIWTLARFV........................
A0A0F5EYK8_AVIPA/12-126              .fdsqtkvgkkcfsslglgkv------------------.......--------.-----....-------------------------....------........-------VDSILPSVEAFN............ER---RDKTIIGSMKTTLRERWQEVVEEVSRsnI..P..N..IYLLTVDDD.ISESKAIQMGTHNIVLVVLDYV.KKQ.SHL.KDKRSIIDFETY-f.......................
#=GC seq_cons                        .....................F+hlEcthhtphlppGFs........sVDpFlp.hu.SV....pNRRKSRAGpuLEpHLptlFptpul....paspps........hTEsppKPDFlFPutpsY+............-.sFss-pLthLusKTTCKDRWRQVLsEAcR..l..p..p..KaLhTLptG.IStsQhcEMpscslpLVVPcsl.+po.Ysp.ptpsplholppFl........................
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