GenomeNet

Database: Pfam
Entry: EcoRII-C
LinkDB: EcoRII-C
Original site: EcoRII-C 
#=GF ID   EcoRII-C
#=GF AC   PF09019.10
#=GF DE   EcoRII C terminal
#=GF AU   Mistry J, Sammut SJ
#=GF SE   pdb_1na6
#=GF GA   20.30 20.30;
#=GF TC   20.40 21.00;
#=GF NC   20.20 19.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   R.EcoRII
#=GF RN   [1]
#=GF RM   14659759
#=GF RT   Crystal structure of type IIE restriction endonuclease EcoRII
#=GF RT   reveals an autoinhibition mechanism by a novel effector-binding
#=GF RT   fold. 
#=GF RA   Zhou XE, Wang Y, Reuter M, Mucke M, Kruger DH, Meehan EJ, Chen
#=GF RA   L; 
#=GF RL   J Mol Biol. 2004;335:307-319.
#=GF DR   INTERPRO; IPR015109;
#=GF CC   The C-terminal catalytic domain of the Restriction Endonuclease
#=GF CC   EcoRII has a restriction endonuclease-like fold with a central
#=GF CC   five-stranded mixed beta-sheet surrounded on both sides by
#=GF CC   alpha-helices. It cleaves DNA specifically at single 5' CCWGG
#=GF CC   sites [1].
#=GF SQ   107
#=GS A0A0A0MAM8_9GAMM/288-443  AC A0A0A0MAM8.1
#=GS A0A0B2BWV1_9SPHN/45-212   AC A0A0B2BWV1.1
#=GS A0A100YQX9_9FIRM/217-380  AC A0A100YQX9.1
#=GS A0A0Q5P0E8_9SPHN/280-440  AC A0A0Q5P0E8.1
#=GS A0A095VNF2_9GAMM/272-440  AC A0A095VNF2.1
#=GS H6LJ76_ACEWD/228-392      AC H6LJ76.1
#=GS G4E5I7_9GAMM/236-400      AC G4E5I7.1
#=GS N9VFS3_9MOLU/78-252       AC N9VFS3.1
#=GS A0A0N1BB99_9PROT/168-329  AC A0A0N1BB99.1
#=GS C5BFF1_EDWI9/227-391      AC C5BFF1.2
#=GS A6H1I6_FLAPJ/118-283      AC A6H1I6.1
#=GS D5QBX9_KOMHA/229-397      AC D5QBX9.1
#=GS A0A0P9E0U8_9ARCH/102-261  AC A0A0P9E0U8.1
#=GS Q727L4_DESVH/225-389      AC Q727L4.1
#=GS Q0AK57_MARMM/222-391      AC Q0AK57.1
#=GS F2NVD3_TRES6/217-382      AC F2NVD3.1
#=GS A0A0B2BUC0_9SPHN/45-212   AC A0A0B2BUC0.1
#=GS A0A0P1H4V7_9RHOB/229-398  AC A0A0P1H4V7.1
#=GS R5VI29_9BACT/92-165       AC R5VI29.1
#=GS T1I3N5_RHOPR/237-407      AC T1I3N5.1
#=GS A1WU40_HALHL/231-398      AC A1WU40.1
#=GS A0A0G1YD81_9BACT/229-393  AC A0A0G1YD81.1
#=GS A8AM36_CITK8/227-391      AC A8AM36.1
#=GS W1J442_9GAMM/233-403      AC W1J442.1
#=GS A0A0E9N2R3_9BACT/228-395  AC A0A0E9N2R3.1
#=GS A0A0Q9TJT7_9BACL/95-264   AC A0A0Q9TJT7.1
#=GS A0A0M4D460_9DELT/235-402  AC A0A0M4D460.1
#=GS Y0KJ88_9PROT/255-425      AC Y0KJ88.1
#=GS A0A0C9NG33_SPHPI/231-394  AC A0A0C9NG33.1
#=GS X7E9Y1_9RHOB/281-441      AC X7E9Y1.1
#=GS A0A0A6Q4M8_9BURK/236-406  AC A0A0A6Q4M8.1
#=GS H2CIA7_9LEPT/227-402      AC H2CIA7.1
#=GS A0A0M0IHG7_9VIBR/232-399  AC A0A0M0IHG7.1
#=GS A0A0P9G5M9_9ARCH/16-109   AC A0A0P9G5M9.1
#=GS A0A139BUE2_9PROT/2-153    AC A0A139BUE2.1
#=GS A0A0A0ENR7_9GAMM/262-419  AC A0A0A0ENR7.1
#=GS L0EBE4_THECK/231-399      AC L0EBE4.1
#=GS H2ISN5_RAHAC/232-396      AC H2ISN5.1
#=GS A5FU96_ACICJ/233-400      AC A5FU96.1
#=GS Q8G4B6_BIFLO/235-405      AC Q8G4B6.1
#=GS A0A062TW84_9RHOB/228-395  AC A0A062TW84.1
#=GS A0A142WTD2_9PLAN/239-406  AC A0A142WTD2.1
#=GS V9H9S8_9NEIS/169-325      AC V9H9S8.1
#=GS A0A081MSF1_9RHIZ/229-397  AC A0A081MSF1.1
#=GS E8SGE7_STAPH/83-249       AC E8SGE7.1
#=GS A0A090VVN6_9FLAO/1-131    AC A0A090VVN6.1
#=GS R7B2S4_9CLOT/217-382      AC R7B2S4.1
#=GS A0A0U2ZDI1_9ALTE/237-404  AC A0A0U2ZDI1.1
#=GS A0A0K9GCN6_9BACI/220-383  AC A0A0K9GCN6.1
#=GS J9ZE30_LEPFM/235-402      AC J9ZE30.1
#=GS A0A0N9U408_SPHMC/228-396  AC A0A0N9U408.1
#=GS A8G987_SERP5/232-396      AC A8G987.1
#=GS H3KI73_9BURK/146-317      AC H3KI73.1
#=GS A0A0C1GSX4_9RHOB/45-210   AC A0A0C1GSX4.1
#=GS E7GQT1_CLOSY/217-382      AC E7GQT1.1
#=GS R9GNB6_9SPHI/226-393      AC R9GNB6.1
#=GS A0A011VQI7_9RHIZ/86-239   AC A0A011VQI7.1
#=GS A0A0F7KX15_9SPHN/228-396  AC A0A0F7KX15.1
#=GS A0A0M0G4X2_9BACI/220-383  AC A0A0M0G4X2.1
#=GS G2IUA0_PSEUL/237-408      AC G2IUA0.1
#=GS C4ZAA8_AGARV/216-381      AC C4ZAA8.1
#=GS A0A0G2AS96_9BACT/229-393  AC A0A0G2AS96.1
#=GS G9RPY3_9FIRM/217-382      AC G9RPY3.1
#=GS A9MS72_SALAR/227-391      AC A9MS72.1
#=GS A0A136L9D4_9CHLR/229-392  AC A0A136L9D4.1
#=GS D3VAD7_XENNA/233-403      AC D3VAD7.1
#=GS N9UPS6_9SPHN/229-303      AC N9UPS6.1
#=GS A0A0J9B3I8_9BACT/227-391  AC A0A0J9B3I8.1
#=GS A0A160F554_9BACI/220-383  AC A0A160F554.1
#=GS K0IIH6_NITGG/84-247       AC K0IIH6.1
#=GS W8VCB3_YEREN/4-45         AC W8VCB3.1
#=GS A0A011U286_9RHIZ/237-404  AC A0A011U286.1
#=GS F9N618_9FIRM/89-258       AC F9N618.1
#=GS A0A0B3RPQ2_9RHOB/229-398  AC A0A0B3RPQ2.1
#=GS B3EB39_GEOLS/231-395      AC B3EB39.1
#=GS A0A074TGC8_9RHOB/229-398  AC A0A074TGC8.1
#=GS N9W987_9SPHN/10-178       AC N9W987.1
#=GS A0A0P1I0Y2_9RHOB/234-402  AC A0A0P1I0Y2.1
#=GS A0A085H7C2_9ENTR/242-406  AC A0A085H7C2.1
#=GS A1A2Y0_BIFAA/83-248       AC A1A2Y0.1
#=GS N9VY31_9SPHN/2-101        AC N9VY31.1
#=GS A0A1B1KKL8_SERPL/234-404  AC A0A1B1KKL8.1
#=GS C4K5I7_HAMD5/230-401      AC C4K5I7.1
#=GS U2UYE2_9FIRM/216-381      AC U2UYE2.1
#=GS X6FN62_9RHIZ/230-399      AC X6FN62.1
#=GS B6GA13_9ACTN/228-394      AC B6GA13.1
#=GS R6ETE5_9FIRM/218-383      AC R6ETE5.1
#=GS A0A0Q0Z4B5_9RHOB/228-397  AC A0A0Q0Z4B5.1
#=GS R5GVJ7_9BACT/218-381      AC R5GVJ7.1
#=GS A0A0V2F1N1_SALNE/1-74     AC A0A0V2F1N1.1
#=GS A0A074MHJ0_9BACL/88-257   AC A0A074MHJ0.1
#=GS Q9JZ51_NEIMB/218-386      AC Q9JZ51.1
#=GS E2ZD30_9FIRM/107-272      AC E2ZD30.1
#=GS A0A081BFA0_9RHIZ/229-397  AC A0A081BFA0.1
#=GS A4ABD8_9GAMM/233-401      AC A4ABD8.1
#=GS A0A0F7HPZ5_9STAP/208-371  AC A0A0F7HPZ5.1
#=GS S6FF02_AVIPA/112-286      AC S6FF02.1
#=GS A0A0J5L1W0_PLUGE/226-390  AC A0A0J5L1W0.1
#=GS Q8KAN4_CHLTE/1-74         AC Q8KAN4.1
#=GS J0N5F7_9CLOT/217-382      AC J0N5F7.1
#=GS A0A0Q4B9U9_9EURY/174-345  AC A0A0Q4B9U9.1
#=GS A0A060UZV4_9PROT/236-403  AC A0A060UZV4.1
#=GS A0A132BVQ4_9RHOB/235-403  AC A0A132BVQ4.1
#=GS A0A168RC58_9MOLU/82-251   AC A0A168RC58.1
#=GS A0A0S2KHM5_9GAMM/236-403  AC A0A0S2KHM5.1
#=GS A0A0F5EYK8_AVIPA/12-126   AC A0A0F5EYK8.1
#=GS A0A139SV32_9GAMM/238-405  AC A0A139SV32.1
A0A0A0MAM8_9GAMM/288-443             ..........gddlastvvrrypdidav---------------...---.......-----.---.-LLSA....SQQRKTRAGRSFEHHIAAALKAGDV....RFQEQA........VTG-..G........RRPDFVLPDLPTLR............KKTRQ.RSDALVLAAKTTLRERWKQVSSEQL..N..C..-..D..VYLATVDDR.VPPTAIHEMAGLGIRLVVPESL.KT.S.DEAfyK..GQNNVLSFREF-f................................................................
A0A0B2BWV1_9SPHN/45-212              ............................FRSVEQAIELPFIQA...GFA.......-TVDD.FVA.RAQTI....LQRRKARSGRSLELHTRAIFVEERLvegtHFVHQP........ESEP..G........KRPDFLFPSVAAYR............DADFP.AERLRMLAVKTTCKDRWRQILNEAD..R..I..P..A..KHLLTLQEG.VSEPQFREMTNAGVQLVVPAGI.ID.T.FPK..G..VRPHLQTLESFI.................................................................
A0A100YQX9_9FIRM/217-380             ............................FRNIEDKFFGSYIKN...GFP.......-TMQA.FIE.TANSV....LNRRKSRAGKSLEHQLSYLFTRNHL....IFDEQV........RTEQ..N........KKPDFVFPGKEAYH............DLSYD.ASKLIVLGAKTTCKDRWRQVVTEAD..R..V..D..V..KYLCTLQQG.ITVQQLKEMQSERVVLVVPRPY.IR.A.YPP..E..FRDSIFDLKTFM.................................................................
A0A0Q5P0E8_9SPHN/280-440             ..................syvtaagiir---------------...SLI.......DNIGE.VDR.LMLSA....SQQRKSRAGYSFEHQIEAMLAAGAV....PFEKQV........VMDA..K........KRPDFILPSLARFI............TPVPG.AANGLILSAKTTLRERWKQVQREMT..G..-..G..D..LFLATVDES.IAANAIEDMASLGIVLVVPETL.RE.S.RST..E..Y-----------vrhsnvigfagff....................................................
A0A095VNF2_9GAMM/272-440             ............................FRRLEKRIVASRLEQ...GFFsd...geADVDG.FVS.FSLSV....QNRRKSRVGHALENHLQEIFDQFGL....AYARGA........CTEG..R........KKPDFLFPGPEAYA............DPEFP.SSSLRMLGVKSTCKDRWRQVLSEAA..R..I..D..H..KHLLTLEPA.ISTDQTAEMQAAQLQLVLPESL.HS.S.YKP..L..QQHWLMSVSQFI.................................................................
H6LJ76_ACEWD/228-392                 ............................FRTLEKHLIRERLKT...GFE.......DDVDA.FIS.FSLSV....QNRRKSRVGQALENHVECLLQNRGI....QYDRTK........ITEN..K........SKPDFIFPSISDYH............NRDFS.VERLTMLGAKTTCKDRWRQVLPEAE..R..I..K..H..KHLLTLEAA.ISENQTEEMIAHNLQLVVPKRL.HQ.T.YSA..K..QQAWLIDVNEF-f................................................................
G4E5I7_9GAMM/236-400                 ............................FRTLEKQIIGERLAQ...GFD.......GDVDG.FIS.FSLSV....QNRRKSRAGLAFENHLEILFEECGV....RYARTP........VTEQ..K........SKPDFIFPGVKEYY............DKSFD.SLRLTMLGVKSSCKDRWRQVLAEAD..R..I..E..K..KHLLTLETA.ISKSQTDEMQSKKLQLVLPRGL.HN.T.YSA..E..QQSWLMDVSGF-t................................................................
N9VFS3_9MOLU/78-252                  elvddnyirnltpidaitwfveefpehi---------------...---.......-----.-YA.LTLSN....TQSRRSRAGKEFESIIELILIGAGI....PLDSQGnigkqvfvSKGI..G........KLVDLVSPGVLEY-............--ILN.KRNTVLISAKTTLRERWQEVPEEMG..R..TgaR..E..MFLATLDDS.ISSDVLNTLYEANIQVTTTKNI.KE.K.YYT..N..-NGRVLTFEKLV.................................................................
A0A0N1BB99_9PROT/168-329             ................gdsqidskravm---------------...ACI.......ENFDE.LYR.VFLSA....SQARASRAGGSFETVVARTLNAGGI....PFAAQN........MFD-..G........SKPDFVLPNASTYE............NDTLR.GDHALILTLKTTLRERWKQVVSESK..N..C..-..P..IYLGTLDEN.ITSATLDKLSDHSIFLVVPERF.KA.SvYTE.yA..NRESVISYRDF-f................................................................
C5BFF1_EDWI9/227-391                 ............................FLQVEELHVLSVIKT...GFS.......-SVDA.FIS.LANSV....SNRRKSRSGKSLELHLENIFYEYGL...tEFETQA........VTEG..N........KKPDFLFPSAKAYH............DDSWP.PQKLRMLAVKTTCKDRWRQILNEAD..R..I..Q..D..IYLFTLQEG.VSITQFREMQEERVRLVVPEKL.HE.K.YPA..E..IRGNLISLNDFI.................................................................
A6H1I6_FLAPJ/118-283                 .........etvkeicgeyagrvfpyiy---------------...---.......-----.--R.LSLSN....TQSRRSRAGKSFEAIIYKIYENLGY....EYDSQSkvgrktfdTLGL..G........KKVDSILPNIKCYA............ERR--.-NKTIIGTMKTSLRERWQEVAEEIE..RtkI..P..E..IHLLTADES.IPKSKAQEMANHNIIVVTYEWV.AN.S.VAL..K..SMKNIISFEEY-l................................................................
D5QBX9_KOMHA/229-397                 ............................FRRLERRVVAEKING...GFQca...egADVDG.FLA.FSLSV....QNRRKARAGSALENHLEAVFQANGI....RYARGA........ETEN..R........NKPDFLFPGKAAYA............DPIFS.ADRLTMLGSKSTLKDRWRQVLSEAV..R..I..R..K..KHLLTLEPG.ISENQTDEMRVKELQLILPQKL.HA.T.FRP..S..QQAWLMNVREFI.................................................................
A0A0P9E0U8_9ARCH/102-261             ......ecedyleftkkicepicpflga---------------...---.......-----.---.LHTKA....SQMRKSRGGKSFERIIRILLNHINV....SCEKPK........GREP..Rk.....vlKRIDGVVPNQETAL............--STP.-DKAFFLLCKRTLRERWKQTIPERK..P..A..W..R..VFLLTIDDE.LSEDKAQEIDQLGIIAYVKDEL.KD.Q.SHL..R..SKDWI-------rrlsdl...........................................................
Q727L4_DESVH/225-389                 ............................FRMFERHLVAQRLRE...GFG.......EDVDA.FTG.YALSV....LNRRKARAGKALENHVEQVLKDWGV....PYTREC........RTEN..N........SKPDFIFPGCSEYH............QTNFP.QDQLRMLAVKSTCKDRWRQVLAEAA..R..V..S..R..KHLLTLEPG.ISVQQTTEMVDHAVQLVIPRGI.QS.S.FQD..A..QREELISLGEFV.................................................................
Q0AK57_MARMM/222-391                 ............................FRALERGIVGDRLML...GFLds..rgePDVDA.FLK.FSLSV....QNRRKSRAGHALMNHFSKILRAFEI....PFTPEA........TTEK..K........GAADFLFPSEAAYA............DPGFP.SANLRMVAAKTSCKDRWRQVLAEAD..R..I..K..P..KHLLTLQPK.ISLAQTTEMTDQGIILTLPSPI.HS.S.FQD..D..QRASLLTVADL-l................................................................
F2NVD3_TRES6/217-382                 ............................FRAIEHDRYGSLIKN...GFS.......-DVEK.FIE.LANQV....LNRRKSRAGKSLEHHLSSLFKGNSI....TFTPQA........ITEG..N........KKPDFIFPSIEAYH............DTSFS.VVKLASLAAKTTCKDRWRQVLNEAD..R..L..RsqN..KFLCTLQQG.ISSAQLEEMKSEKVVLVVPERY.IK.T.YPE..K..YQQDIWTVKKFI.................................................................
A0A0B2BUC0_9SPHN/45-212              ............................FRSVEQAIELPFIQA...GFG.......-TVDD.FIA.RAQTI....LQRRKARSGRSLELHTRAIFMEERLvegtHFAHQP........ESEA..G........KRPDFLFPSVTAYR............DANFP.ADRLRMLAVKTTCKDRWRQILNEAD..R..I..P..A..KHLLTLQEG.VSEPQFREMTNAGVQLVVPAGI.VD.T.FPK..G..VRPHLQTLESFI.................................................................
A0A0P1H4V7_9RHOB/229-398             ............................FRRLERKVVSSRIEA...GFVdd...sgTDVDG.FIS.FSLSV....QNRRKSRMGHSLENHLAAVLRAHDI....RHVRGA........VTEH..K........HKPDFLFPDLETYL............AASTEgDARLTMLGAKSTCKDRWRQVLAEAE..K..I..S..R..KHLLTLEPG.ISEPQTDQMEASSLQLVVPAPV.HG.S.YTD..T..QRGWLWSVGDFI.................................................................
R5VI29_9BACT/92-165                  ............................FKALEIKIYGDKLKS...SFN.......-DMDD.LIG.FSNTM....LNRRKSGAGKSLEHHLAQIFTNAGL....RFETQE........MTEG..K........KKPDFLFP------............-----.-------------------------..-..-..-..-..---------.----------------------.--.-.---..-..------------.................................................................
T1I3N5_RHOPR/237-407                 ............................FRTLERYLIADKLSK...GFSpkg.ngiVDTDG.FLQ.FSLSV....QNRRKSRVGLALENHLEIIFKENGI....RYSRGV........VTEN..R........CKPDFLFPSIVEYR............DPDFA.HFNLTMLGVKSTCKDRWRQILSEAS..R..I..P..A..KHLLTLQPS.ISENQTKEMATENVQLVVPALL.HS.T.YSS..E..QQKWLKDLNTFI.................................................................
A1WU40_HALHL/231-398                 ............................FRAYEREIVQERLER...GFA.......GDVDE.FIR.FSLSV....HNRRKSRVGHAFENHLTELFERHGL....RFEKGGv.....nrVTEN..K........SKPDFLFPGFTEYH............DPQFP.NSRLFLLGAKTTCKERWRQVLAEGE..R..L..K..R..KHLATLEPG.ISRTHTDEMSAHGLQLVVPLPI.HA.T.YSE..T..QRMKIMGIQDFI.................................................................
A0A0G1YD81_9BACT/229-393             ............................FRALERHIVRDRISK...GFG.......ADVDS.FIS.FSLSV....QNRRKARMGQSLENHLAHLFTESGI....RYSKNK........NTEG..K........KKPDFLFPGVEQYH............DPKFP.AESLTMLGAKSSCKERWRQVLSEAG..R..I..T..E..KHLITLEPG.ISVDQTKEMQESSLQLVVPDSI.HK.T.YSD..R..QRDWLMSVKEFI.................................................................
A8AM36_CITK8/227-391                 ............................FLLVEEMHVLGIVQS...GFG.......-SVNE.FIA.LANSV....SNRRKSRAGKSLELHLEQLFNEHGL...kTFETQA........VTEG..N........KKPDFLFPSAQAYH............DEAFP.EQKLRMLAVKTTCKDRWRQILNEAD..R..I..Q..D..IYLFTLQEG.VSVAQFQEMQQERVRLVVPSSL.HD.K.YPK..A..IREYLISLETFI.................................................................
W1J442_9GAMM/233-403                 ............................FKTYERYEVAKKLSQ...GFGe....ngNDVDE.FIH.FSLSV....QNRRKSRAGFAFENHLDHLFSLHNL....QFQQGSa.....knITEN..K........SKPDFLFPCFSAYH............DKSFP.QEKLRLLGAKTTCKDRWRQVLAEGD..R..V..A..R..KHLITMQPG.ISEQQLAEMKSKSLQLVVPESV.KS.L.YPI..S..YANDLQNVMEFI.................................................................
A0A0E9N2R3_9BACT/228-395             ............................FKALEAKIVSAKLKN...GFGl....vsSEVEE.FIS.FSLSV....QNRRKSRAGHAFENNLAKIFEVNNI....YFAKGA........TTER..S........NKPDFLFPGLSEYQ............NLTFP.ADMLTMLGVKTTAKDRWRQILMEAD..R..V..S..L..KHLITLEPS.ISKNQTDEMIAQKIQLILPEPL.LS.T.YTQ..S..QQQTLITLSQFL.................................................................
A0A0Q9TJT7_9BACL/95-264              ..................slddkqklvn------------IVT...GFS.......SNYEEhLFE.LNKSN....TNSRRSRAGKEFEGLLKKILIKSNI....SFDDQG........AVGT..KkfsegglsKIVDYVVPGVLEYG............---IE.KTHCALISMKTSLRERWQEVPEELS..R..T..G..AhfMYLFTLDRD.ISNEVITSLSEHKIYLVVLDVH.KN.D.YYS..S..------------dnriyglsell......................................................
A0A0M4D460_9DELT/235-402             ............................FRSIEEAIELPNVLR...GFL.......-TIDE.FLA.RAQTI....LQRRKARSGRSLELHALEIFLEEGLveneNFTHQP........ESEH..G........KRPDFLFPSAALYK............TTTFP.ASQLRMLAVKTTCKDRWRQIINEAD..R..I..K..E..KHLLTLQEG.VSVGQFHEMTEAGVRLVVPEAL.KS.N.YNK..K..IQPYLQSLESFI.................................................................
Y0KJ88_9PROT/255-425                 ............................FRIYERNIVQERLRA...GFGn....ngEDVDA.FID.FSLSV....QNRRKSRVGHAFEGHIGCLFDQNGL....QYEQGRgk....gkVTEN..N........AKPDFIFPSFEAYH............AAE-P.NTGIYMLGAKTTCKDRWRQILPEAN..K..I..S..T..KHLITLEAA.ISEQQTFEMQHHQVQLVIPAAI.HA.T.YKS..S..QVDYLWTVADFI.................................................................
A0A0C9NG33_SPHPI/231-394             ............................FRTLERHLIGDRLQA...GFG.......-EIDD.FLQ.FSLSV....QNRRKSRAGSALENHLEHMFATLGI....VGDRTP........VTEG..K........AKPDFLFPGTKAYQ............DENFP.PELLTMLGVKSTCKDRWRQVLAEAD..K..I..P..D..KHLLTLEPS.ISANQTDEMQQRRLQLIVPSGL.HH.T.YTA..A..QQRWLMSVGNLI.................................................................
X7E9Y1_9RHOB/281-441                 ........klvetagvirrlveelprvd---------------...---.......-----.--A.LMLSA....AQQRKSRAGYSYEHHIEAMLQGGRI....PFEKQV........VIEA..R........KRPDFILPSLAFVN............GGSQH.AGTGLILSAKTTLRERWKQVEREK-..G..T..R..R..LYLTTVDEN.IAGNAIEDMASIGVHLVIPESL.KK.A.KET..E..------------ydghanvqtfqelc...................................................
A0A0A6Q4M8_9BURK/236-406             ............................FRTLERYLIADRLSA...GFAada.ekkVDVDG.FLA.FSLSV....QNRRKSRVGLALENHLEVLFAANDI....RYARTA........ATEN..K........SKPDFLFPGSKEYH............DAAFD.PVRLTMLGVKSTCKDRWRQVLAEAD..R..I..P..D..KHLLTLETA.ISLTQTNEMRAKHLQLVLPTKL.HE.S.YTQ..E..QRGWLKSVAEFM.................................................................
H2CIA7_9LEPT/227-402                 ............................FRYFERKHYQPLIEE...GFQ.......-RIDD.FLS.LSLEI....HNRRKSRAGNSLEIHLKYVFDRSRI....ACAHGV........ITSD..Q........RRPDFLFPSLDAYEsyrvrhreaennVSSSD.AEGVFFLAAKTTCKDRWRQILTEAP..G..V..N..R..RYLFTLQQA.ISKAQLDEMSDEGVTVVMPESY.RR.K.FDA..Q..NRGRIMSLAEFI.................................................................
A0A0M0IHG7_9VIBR/232-399             ............................FRQLEKHIVKEKLKC...GFGe....ngDDVDE.FVS.FSLSV....QNRRKSRSGHAFENHIEHILLENQI....VFQRGA........VTEG..K........QKPDFLFPSSKCYQ............DLTFP.AESLRILGAKTTCKDRWRQVLAEGK..R..V..N..K..KHLITLEHA.ISEAQTSQMQSHNLQLVVPQAL.HS.T.YTE..Q..QAGWLMSFGNFI.................................................................
A0A0P9G5M9_9ARCH/16-109              ...........kridgvvpnqetalstp---------------...---.......-----.---.-----....-------------------------....------........----..-........--------------............-----.-DKAFFLLCKRTLRERWKQTIPERK..P..A..W..R..VFLLTIDDE.LSEDKAQEIDQLGIIAYVKDEL.KD.Q.SHL..R..SKDWI-------rrlsdl...........................................................
A0A139BUE2_9PROT/2-153               ...................issvvrgfp---------------...---.......----D.FDA.TFLSA....SQHRKSRAGRSFEQHISRLLRDGRI....VFEEQA........VTAG..-........RRPDFVLPSLVVLV............AKKRK.FEEAMVLSAKTTLRERWKQVAMEKF..N..C..-..A..LFLATVDDR.VSAAAIDDMSNQGIHLVVPESL.KK.S.KETcyN..GKTNVITFREFL.................................................................
A0A0A0ENR7_9GAMM/262-419             .........adssdlttavvrrfpeidr---------------...---.......-----.---.VFLSA....SQQRKNRAGRSFEHHIAASLKAGHI....RFTEQA........VTG-..G........RRPDFVMPDLSALR............SKKRT.YAEALVLAAKTTLRERWKQVSSE--..R..L..N.cD..VFLATVDDR.VAASSIREMANADIRLVVPEAL.KS.S.DEA..HykGQPNVLSFREF-f................................................................
L0EBE4_THECK/231-399                 ............................FKRLERHIISKKLEH...GFRdn...dsIDVDG.FLQ.FSLSV....HNRRKSRVGYALENHLEEIFKIHEI....TYSRTA........ITEN..K........SRPDFLFPGADHYH............DPAFP.SERLTMLGVKSTCKDRWRQVLAEAD..R..I..K..S..KHLLTLEPG.ISENQTDEMQASNLQLVLPQPL.HE.T.YKP..R..QRCWLINLSDFI.................................................................
H2ISN5_RAHAC/232-396                 ............................FLHIEEFHVLHKIKD...GFN.......-SVNE.FIA.LANSV....SNRRKSRAGKSLELHLEVIFKDNNL...lDFSTQC........VTEG..N........KKPDFIFPSGQAYH............DFNYP.EEKLRMLAVKTTCKDRWRQAINEAD..K..I..K..K..VHLFTLQEG.VSVNQFNEMKEAGIILVVPKPL.HE.K.YPK..D..IRMELVTLEDFI.................................................................
A5FU96_ACICJ/233-400                 ............................FLSVEEAVYLPRIRQ...GFS.......-AIGD.FLS.LAQTI....LQSRKTRSGTSLELHVREIMTEEGLladtSFTYRP........VIEN..G........KRPDFLFPSKAAYD............NPAFP.AERLRMLAAKTTCKDRWRQVLNEAD..R..I..A..T..KHLLTLQEG.VSEGQFREMSEAGVRLVVPAEL.HR.S.YPA..S..VRPHLVTFENFI.................................................................
Q8G4B6_BIFLO/235-405                 ............................FKLYERAVIQHDYDA...APFvs..dgvIDVDS.FTS.FYTSV....RNRRMSRAGKVLEIHIAHILDARGI....EYEAQA........KTEN..G........KKPDFLFPSQAAYE............DPAFP.EEQLRMLASKTSIKDRFRQVADEAN..R..I..R..D..KHLFTLTPGdVTHPKLAQLDELHIHLVMPKVV.KE.S.YDD..L..IQGETMTFSRFI.................................................................
A0A062TW84_9RHOB/228-395             ............................FRSVERAFFTPRLQR...GFS.......-DLEA.FLA.MAQTI....LQSRKSRSGKSLEYHAKSIFDEVGLregvDYEYNP........KIEG..N........KKPDFLFPTSAQYR............DLSYP.SEGLTVLAAKTTCKDRWRQILNEAD..R..V..S..T..KYLLTLQEG.VSLNQFSEMSSSGVKLVVPKKL.HS.K.YPE..S..IQREILSLEGFL.................................................................
A0A142WTD2_9PLAN/239-406             ............................FQSLEEATELPIIRN...GFD.......-NIED.FLA.RAQHI....LQRRKSRAGLSLELQTREIFLEENLlqgtDFDHQP........ESEP..G........KHPDFLFPSKSHYS............DPAFP.ASRLRMLAAKTTCKDRWSQVLTEAQ..R..I..P..E..KHLLTLQEG.MSVRQFTNMTEAGIRLVVPTPI.IG.K.FPS..Q..VRPHLQSLESFI.................................................................
V9H9S8_9NEIS/169-325                 ...............fihklvqeaqtll-------------EQ...GIE.......PNQIF.MLV.FNESL....NQSITSNSGSDYESRIKSVLLRLGL....PASNI-........----..Q........KKHD-LADSSTEFD............FFFEY.NGKTFGISAKRTLRERYKQFIKTAQmsQ..I..D..V..MIEITLGTD.LSKDKVKAIRQHNVYLFVADEI.Y-.-.---..-..------------csqtylqsingvys...................................................
A0A081MSF1_9RHIZ/229-397             ............................FRRLERRIVAERISS...GFQvt...dgADVDG.FLH.FSLSV....QNRRKSRAGSALENHLEAVFADHGI....AFVRGA........ETEN..R........NKPDFLFPGQSEYR............DLAFP.SERLTMLGSKSTLKDRWRQVLSEAE..R..I..P..N..KHLLTLEPG.ISENQTDEMRTKHLQLVIPRSI.QT.S.FRP..A..QRDWLISVRDFL.................................................................
E8SGE7_STAPH/83-249                  ...........lgldniesikwfvenfp---------------...---.......---DH.IYR.LSLSN....TQSRRSRAGKEFEIIIELILMGANI....PFDTQGsigsgvfeSSEL..A........KLVDCVSPGALEYK............---LD.KRNTSLISAKTTLRERWQEVGDEMA..R..T..KarE..MYLVTLDEN.ITSQTMKLISANNIVIVTTNSIlND.N.YKK..M..------------hgiisveeml.......................................................
A0A090VVN6_9FLAO/1-131               ...........................m---------------...---.......-----.---.-----....-------------HHISFLLGKHGFelekDYQREF........VLKE..G........CKLDFFFPDLENYK............NE---.PKNCCSVACQTTSNDRFRLTFA---..-..-..-..-..---------.----------------------.--.-.---..-..------------qmpadtrnractaignsnfgdklgpdslsnnkldeakkngvkfvifehaidnrliasqtvmsynd
R7B2S4_9CLOT/217-382                 ............................FRALEYARYGDIITK...GFQ.......-SVDE.FVR.VANVV....LNRRKSRAGKSLEHHLSAIFDGNGI....EYSSQA........VTEG..N........KKPDFLFPSQEAYH............DYDFS.TDYIISLAAKTTCKDRWRQVLNEAD..R..L..R..DkpKYLCTLQQG.ISGAQMDEMQAENVILVVPKPY.IA.T.YPK..D..RRDRIWTLARFV.................................................................
A0A0U2ZDI1_9ALTE/237-404             ............................FRIQERHIVSERLKS...GFGk....sgHDVDE.FIK.FSLSV....QNRRKSRVGHAFENHITEILERNKM....KFECGV........YTEG..K........HKPDFLFPSQDAYL............DASFN.RDKLFSLAAKTTCKDRWRQVLTEAQ..R..I..S..T..KHLITLEPS.ISKEQTEQMKSLNVKLIIPTKI.QY.T.YTE..E..QRVDIWSLKNFI.................................................................
A0A0K9GCN6_9BACI/220-383             ............................FKVLERHLYQEYLTK...PFG.......-EVEP.LVA.VANTI....LNRRKSRAGKSLEHHVDFLFRSFSL....PFAHPG........RSEG..N........KKPDFLLPSNAAYA............DMNYQ.ASDLIFLGCKTTCKDRWRQILNEAN..R..I..P..E..KHLLTLQQG.ISSNQLDEMADENVTLVVPKPY.HS.M.YPV..E..YRDRIWTVEKFI.................................................................
J9ZE30_LEPFM/235-402                 ............................FQSVEEAIELPVIRR...GFS.......-SVSE.FVD.RAQTI....LQRRKSRSGKSLELHLKEIFLEDGLsegrDFSCQA........ESEP..G........KRPDFIFPSEAAYR............DPSFP.SEKLRMLAAKTTCKDRWRQILNEAD..R..I..Q..V..KHLLTLQDG.VSENQFREMSESGVQLVVPKSL.HD.S.YPP..N..IRQNLLTLKDFI.................................................................
A0A0N9U408_SPHMC/228-396             ............................FRRLERRIVAARIGD...GFRaa...dgADVDG.FLS.FSLSV....QNRRKARAGQALENHLEAVFQAQGI....RYLRGA........ETEN..R........NKPDFLFPGQAEYR............DPAFP.AERLTMLGAKSTLKDRWRQVLSEAV..R..I..E..E..KHLLTLEPG.ISENQTDEMQAKKLQLVVPQRL.HA.T.YRP..A..QRAWLMRLGDFV.................................................................
A8G987_SERP5/232-396                 ............................FRQIEEIHVLDKIKK...GFN.......-SVEE.FIE.LANSV....SNRRKSRSGKSLEMHLEKIFLANGL...tTFTTQS........ITEG..K........KKPDFLFPSGIEYH............NPAYP.AENLRMLAVKTTCKDRWRQAINEAN..R..I..N..N..IHLFTLQEG.VSANQFQEMKDAGVTLVVPEPL.HK.K.YPE..K..IRSELVSLSDFI.................................................................
H3KI73_9BURK/146-317                 .......leprllrqalrrkfagerslq------------LEK...MTA.......RQFDD.ILE.ATSST....LSSLKTRSGCALHHHVAHILSERGV....SYTERG........DADD..A........QPAGFILSVADAMS............EADHP.AER--FLASKPELKDDWRKVFTDIE..D..I..R..V..KYLLTLDCS.ISEASLEDMTAAGVRLVVPQPY.RQ.T.YPA..S..LQRRIITFADFI.................................................................
A0A0C1GSX4_9RHOB/45-210              ............................FQSLEEAVELPRAQA...GFA.......-TIAE.FLA.AAQTV....LQRRKARSGKSLELHMREILIEEAFqegkDFTYQP........KSGN..-........-NPDFIFPNEAAYL............DATCP.RERVHMLAVKTTFKDRWRQVTEECS..D..L..P..T..RHLLTLQEG.VSEAQFKLITDAGIRLVVPEKR.IE.R.YAK..D..IRPHILTVEAFM.................................................................
E7GQT1_CLOSY/217-382                 ............................FRELEYARYGDIIKK...GFQ.......-SVDE.FVK.VANMV....LNRRKSRAGKSLEHHLAAIFDGNKI....EYTAQA........VTEG..N........KKPDFIFPSQTAYH............DTRFS.IDYLVSLAAKTTCKDRWRQVLNEAD..R..L..R..DksKYLCTLQQG.ISGAQMDEMQAENVVLIVPRPY.IK.A.YPA..D..RQERIWTLSRFV.................................................................
R9GNB6_9SPHI/226-393                 ............................FRTLEGVIVKEQLKK...GFGi....dgTDVDE.FIK.LSLSV....QNRRKSRAGHSFEHNLAILFSINKI....RYSHGA........VTER..N........NKPDFLFPGISEYN............NDGFD.INLLTMLGVKTSAKDRWRQVLSEAK..K..I..D..H..KHLITLEPS.ISNNQIEEMKANNLQLVIPAPL.FS.T.YTK..S..QQKELFSVKDFM.................................................................
A0A011VQI7_9RHIZ/86-239              ........sgataddvfsflenrfhaid---------------...---.......-----.--R.LCLSL....SQSRRTRAGSTFETIVTTLFRKLGY....PHTPQP........QI-N..G........SRPDYVLPSLAHYL............--AYS.SD-CIIFTCKRTLRERWRQAITEGV..-..T..G..Q..FFLATVDDQ.LSVQQIDAMKEKNVVLVVPAGL.KN.T.A-Y..K..DRMNVVSFETF-f................................................................
A0A0F7KX15_9SPHN/228-396             ............................FRRLERRIVTARIGD...GFRap...dgADVDG.FLS.FSLSV....QNRRKARAGQALENHLEAVFGAQGI....CYVRGA........ETEN..R........NKPDFLFPGQEEYR............DPDFP.AARLTMLGAKSTLKDRWRQVLSEAV..R..I..E..E..KHLLTLEPG.ISENQTDEMQAKRLQLVVPQRL.HN.T.YRL..T..QQAWLMDVTSFL.................................................................
A0A0M0G4X2_9BACI/220-383             ............................FRTLEKKLYQEYLTK...PFL.......-EVEP.LIT.VANSI....LNRRKSRAGQSLEHHVDFLLNSFQL....PFAHPG........KSEG..N........KKPDFLLPSNNAYS............DSNYP.TSSLIFLGAKTTCKDRWRQILNEAN..R..I..S..E..KHLLTLQQG.ISANQLDEMAEEKVTLVVPEPY.HK.M.YPA..E..YRDRLWTVEKFI.................................................................
G2IUA0_PSEUL/237-408                 ............................FRIYERHLVQDRLRA...GFGd....hgDDVDE.FIS.FSLSV....QNRRKSRVGHAFEGHLDHLFRLHKL....KFQQGRgk....ghVTEN..N........AKPDFLFPSFTDYN............NPDFP.TDNLIMLGAKTTCKDRWRQVLSEAA..R..I..P..S..KHLVTLEAA.ISEAQTDEMASHNLKLVIPATV.HA.T.YSE..K..QKHWLLDLQEFI.................................................................
C4ZAA8_AGARV/216-381                 ............................FRALEEYRYGDIVRC...GFP.......-SVEE.FVS.VANSV....LNRRKSRAGKSLEHHLEAIFVANEI....IYDAQP........VTEG..K........KKPDFLFPSAVAYR............DLTYP.VSKLATLAAKTTCKDRWRQILNEAN..R..L..KdeN..KFLCTLQQG.VSPMQMDEMEAEKVILVVPKPY.IS.C.YPR..D..RQDRIWTISRFV.................................................................
A0A0G2AS96_9BACT/229-393             ............................FRALERHIVRDRISK...GFG.......ADVDS.FIS.FSLSV....QNRRKARMGQSLENHLAHLFTESGI....RYSKNK........NTEG..K........KKPDFLFPGVEQYH............DPKFP.AESLTMLGAKSSCKERWRQVLSEAG..R..I..T..E..KHLITLEPG.ISVDQTKEMQESSLQLVVPDSI.HK.T.YSD..R..QRDWLMSVKEFI.................................................................
G9RPY3_9FIRM/217-382                 ............................FRALEYARYGAMITG...GFA.......-TVED.FIT.TANQV....LNRRKSRAGKSLEHHLSALFSGNGL....QFEEQA........VTEG..N........KKPDFLFPSQEAYH............TATFP.TEKLISLAAKTTCKDRWRQVINEAD..R..L..RgrP..KYLCTLQQG.ISTAQLDEMAAEQIILVVPKPY.IA.S.YPR..D..RQDRVWTLRHFV.................................................................
A9MS72_SALAR/227-391                 ............................FLLVEEMHVLGMVQS...GFD.......-SVNE.FIA.LANSV....SNRRKSRAGKSLELHLEQLFNEHGL...tTFETQA........VTEG..N........KKPDFLFPSAQAYH............DETFP.EQKLRMLAVKTTCKDRWRQILNEAD..R..I..Q..D..IYLFTLQEG.VSVAQFQEMQQERVRLVVPNSL.HD.K.YPK..T..IREYLISLETFI.................................................................
A0A136L9D4_9CHLR/229-392             ............................FRAMEDVIVSNKLRE...GFA.......-DVDD.FIK.YSLSV....QNRRKSRMGHALMHHLAAVFDAYDL....KYEREV........VTER..K........NRPDFLFPGKSKYD............DPGFP.ATQLVMLGAKSTLKDRWRQILTEAD..R..I..P..S..KHLCTLEPG.ISRDQTDEMLMQRLTLVIPSGL.HQ.T.YLP..E..QRDSLLTLQQFI.................................................................
D3VAD7_XENNA/233-403                 ............................FKVYERHEVAKKLSQ...GFGe....ngNDVDE.FIH.FSLSI....QNRRKSRAGFAFENHLNQLFLLHNL....QFQQGSa.....knITEN..K........SKPDFLFPCFSAYH............DKFFP.QENLRLLGAKTTCKDRWRQVLAEGD..R..V..V..R..KHLITMQPG.ISEQQLAEMKNKSLQLVVPESV.QS.L.YPV..S..YANDLQNVMEFI.................................................................
N9UPS6_9SPHN/229-303                 ............................FRRLERKIVAERLRA...GFKtk...ngEDVDG.FIS.FSLSV....QNRRKSRAGLALESHIEALLNAFEI....NYSRGA........ITEN..G........NKPD----------............-----.-------------------------..-..-..-..-..---------.----------------------.--.-.---..-..------------.................................................................
A0A0J9B3I8_9BACT/227-391             ............................FLLVEELHVLEIIKQ...GFG.......-SVDA.FIS.LANSV....SNRRKSRAGKSLELHLERVFMEHGL...tTFSSQA........VTEG..N........KKPDFLFPSEEDYH............DKSFP.DQHLRMLAVKTTCKDRWRQALNEAD..R..V..E..T..IHLFTLQEG.VSVTQYAEMQQEGVQLVVPAAL.HS.K.FPK..S..VQETLMTLGEFI.................................................................
A0A160F554_9BACI/220-383             ............................FRAIEKNVYKDYLTI...PFN.......-DLET.LIT.VANSV....LNRRKSRAGKSLEHHVDFLLTSFNI....PFSHPG........KSEG..N........KKPDFLFPSNEAYA............NFSFP.EKDLIFLGVKTTCKDRWRQILNEAD..R..I..K..E..KHLLTLQQG.ISPNQLEEMETEKVTLVVPKPY.HS.F.YPA..T..YQHKLWTIEKFI.................................................................
K0IIH6_NITGG/84-247                  ...........peieantknqkefvsel---------------...---.......--LDI.FMP.VAVSFefrtSQMRKSRAGTTFEHITVFLLQKCGI....KCERTAk......sVRKK..M........NRMDIVIPNQEVAL............K---K.PDQAKFLSCKHTLRERWKQALPEKN..R..N..W..V..MYLITMDDD.IPDQKAKEINDHNLIVYVKDQV.KA.K.SYL..A..KKDW--------irklsdl..........................................................
W8VCB3_YEREN/4-45                    ........................sflt---------------...---.......-----.---.-----....-------------------------....------........----..-........--------------............-----.-------------------------..-..-..-..-..---------.---IQTDEMASKCLQFVLPRGL.HQ.T.YTP..A..QQTWLMDVATF-t................................................................
A0A011U286_9RHIZ/237-404             ............................FRSVEEAVELPGIRA...GFT.......-AIDD.FIS.RAQSI....LQRRKSRSGRSLELHAREIFIEERLredlDFAHGP........ESDP..G........RRPDFLFPSQTAYR............NPAFP.SAQLRMLAVKTTCKDRWRQILNEAD..R..I..P..V..KHLLTLQEG.VSEGQFREMTEAGVQLVVPVPL.VS.S.FPK..S..VQPHLQSFESFI.................................................................
F9N618_9FIRM/89-258                  ....kdidtmgskeainwftsefpshiy---------------...---.......-----.--S.LNLSN....TQSRRSRAGKEFEAIIELILMGANI....PLDSQGsvg..tryFTEK..Gl......gKLVDIVSPGSTEYT............V---N.KRDTVLISAKTTLRERWQEVPEEMA..R..TgaR..E..MFLVTLDES.ISQDVIETLNDNNIQLVTTKSI.KE.I.YYP..N..N-HSVITLEKL-l................................................................
A0A0B3RPQ2_9RHOB/229-398             ............................FRRLERRVVSSRIEA...GFTsa...dgTDVDG.FIS.FSLSV....QNRRKSRMGHSLENHMAAVLRAHDI....RHVRGA........VTEH..K........HKPDFLFPDLETYH...........aAPAGG.DARLTMLGAKSTCKDRWRQVLAEAE..K..I..S..R..KHLLTLEPG.ISEPQTDQMEASSLQLVVPSPV.QD.S.YTA..A..QRGWLWSVGDFI.................................................................
B3EB39_GEOLS/231-395                 ............................FRTLERHIIGDRLQV...GFV.......DDVDG.FVT.YSLSV....QNRRKSRAGSSLENHLEVIFNAQGI....QYTRTP........VTEN..N........EKPDFIFPDIIHYR............DPDFD.VSKLTMLGVKSTCKDRWRQILSEAD..R..I..K..S..KHLLTLEPG.ISENQTNQMKRSNLQLVVPSAL.QR.T.YKT..E..QQTWLLTFDDFI.................................................................
A0A074TGC8_9RHOB/229-398             ............................FRRLERKVVSSRIEA...GFVdd...sgTDVDG.FIS.FSLSV....QNRRKSRMGHSLENHLAAVLGAHDI....RHVRGA........VTEH..N........HKPDFLFPDLETYQ...........aAPAGG.DPRLTMLGAKSTCKDRWRQVLAEAE..K..I..S..R..KHLLTLEPG.ISGPQTDQMEASGLQLVVPSPV.HG.S.YTD..A..QRGWLWSVGDFI.................................................................
N9W987_9SPHN/10-178                  ............................FRHMERLVVADRVKD...GFFeg...dkADVDG.FLS.FSLSV....QNRRKSRAGYAFAHHVEALLVACDV....RYKREA........TTEK..R........NAADFLFPGEAEYA............DLAFA.PEKLRMLAVKTTCKDRWRQVLAEAD..R..I..P..L..KHLLTLEPS.ISRAQTDEMKSQLLQLVVPAGI.HE.S.YHA..E..QREWLMAVRDFV.................................................................
A0A0P1I0Y2_9RHOB/234-402             ............................FRHLEREIVSDRLKA...GFMeq...gsADVDG.FLS.FSLSV....QNRRKSRAGYAFGHHVEAILHAHGV....SYTREA........TTEK..R........NAADFLFPGEDEYA............DRRYP.DDQLAMLAVKTSCKDRWRQVLAEAD..R..I..R..T..KHLLTLEPA.ISKIQTAEMQGQGLQLVLPASL.HS.T.YQA..D..QRAWLIGVGDFL.................................................................
A0A085H7C2_9ENTR/242-406             ............................FLLVEELHVLDIIQG...GFE.......-SVDE.FIA.LANSV....SNRRKSRAGKSLELHLEHLFIEHGL...rHFATQA........VTEG..N........KKPDFLFPSAEAYH............NVEFP.RENLRMLAVKTTCKDRWRQILNEAD..K..I..H..Q..VHLFTLQEG.VSQAQYREMREAGVRLVVPSSL.HK.K.YPE..A..VREELMTFGAFI.................................................................
A1A2Y0_BIFAA/83-248                  ..........fkgmeavdaikkfvsdyp---------------...---.......---QH.IYE.LTLSN....TQSRRSRAGKEFEAIIEMMLIGASI....PTDSQGnvgkqffaQHHL..G........KLVDFVTPGAIQYS............---ID.KQRTVLISAKTTLRERWQEVPEEVT..R..TgaP..R..MYLATLDSD.ITENTLNVLYESNITIVTTKEN.RS.H.YTN..-..--PRVMTFEEMI.................................................................
N9VY31_9SPHN/2-101                   ..........................rg---------------...---.......-----.---.-----....-------------------------....------........----..-........ARHDFLFPGAAHYA............DSAFP.ADRLTMLGAKSTLKERWRQVLSEAE..R..I..E..T..KHLLTLEPG.ISLKQTAEMQAKQLQLVLPRDL.HA.T.YKP..E..QQAWLMNISDFI.................................................................
A0A1B1KKL8_SERPL/234-404             ............................FRTYERHLVRARLLQ...GFGd....dgGDVDA.FVD.FSLSV....QNRRKSRVGFAFENHLDHLFKLYGL....QFEKGSs.....knTTEN..R........SKPDFLFPSFKAYH............DDKFP.TDKLFLLGAKTTCKDRWRQVLAEGD..R..L..E..T..KYLVTIQAG.ISNSQLSEMKSKKLQLIVPKTI.WG.T.YPD..E..AHQQLASVREFI.................................................................
C4K5I7_HAMD5/230-401                 ............................FRTLESYLIADRLSQ...GFSgkasvaaVDVDG.FLS.FSLSV....QNRRKSRVGLALENHLEVLFSENGL....RYTRTA........VTEN..K........AKPDFLFPGVTEYH............NPAFD.PLKLTMPGVKSTCKDRWRQVLAEAD..R..I..D..N..KHLLTLETE.ISTHQTDEMAAKRLQLVLPRSL.YQ.T.YTP..S..QQTWLIDVASF-t................................................................
U2UYE2_9FIRM/216-381                 ............................FRTIEHDRYGGIVTA...GFS.......-TVDD.FLT.LANKI....LNRRKSRAGKSLEHHLAALFDAYSI....VYTAQG........ITEG..K........KKPDFLFPSAEKYH............DISFP.TEKLCTLAAKTTCKDRWRQVLNEAN..R..L..R..SkpKYLCTLQQG.ISSAQMDEMQEECVVLVVPKPY.IK.T.FPR..T..RQNRIWTIHKFV.................................................................
X6FN62_9RHIZ/230-399                 ............................FRRLERHIVAGRLSN...GFVgg..dgiADVDG.FLA.FSLSV....QNRRKSRAGQSLEHHLEALFQARSI....RFSRGA........ETEN..R........NRPDFLFPGHAEYN............DPDFS.PDLLTMLASKSTLKDRWRQVLPEAA..R..I..P..S..KHLLTLEPA.ISENQTDQMKAERLQLVLPAKL.HE.T.YRE..S..QRPWLMTLLDFV.................................................................
B6GA13_9ACTN/228-394                 ............................FKVFERHLLERDLAP...YLNg.....vLDVDG.ILK.TTMST....FQRRKSRAGTAFEHQLEFLFKGRGI....RYSSQP........YTEG..K........SKPDFIFPSIECYR............DDAFP.PDCLTMLGAKTTIKERWRQVLEEAN..R..I..A..H..KHLITLEPA.VSVDYTNAMRASSLQLVVPHEL.FA.T.YTT..S..QQEWLMDVASF-c................................................................
R6ETE5_9FIRM/218-383                 ............................FRAIEHARYGETISR...GFD.......-SVDS.FIT.MANMV....LNRRKSRAGKSLEHHLSAIFDGNSI....AYSAQA........VTEG..N........KKPDFIFPSQEAYH............NATFP.TDRLISLAAKTTCKDRWRQVINEAD..R..L..R..DrpKYLCTLQQG.ISPAQMDEMQSENVILVVPKPY.IS.S.YPA..D..RQNRIWTLSQFV.................................................................
A0A0Q0Z4B5_9RHOB/228-397             ............................FRRLERKVVSSRIEA...GFVdd...tgTDVDG.FIS.FSLSV....QNRRKSRMGHSLENHLAAVLRAHDI....RHVRGA........VTEH..K........HKPDFLFPDLETYQ...........aAPAEG.DARLTMLGAKSTCKDRWRQVLAEAE..K..I..S..R..KHLLTLEPG.ISEPQTDQMEASSLQLVVPSPV.HS.S.YTD..A..QRGWLWSVGDFI.................................................................
R5GVJ7_9BACT/218-381                 ............................FRNFEDKFYRDAYQR...PFS.......-CCQD.LID.FANSI....LNRRKSRAGKSLEHHLATIFSANRL....HYEQQI........VTEG..N........KRPDFIFPSGKAYH............DIVFP.TKDLVFLGAKTTCKDRWRQILNEAN..R..I..K..D..KYLFTLQQG.ISKNQLSEMKSEHVTLVVPEAY.RQ.S.FPE..E..FRANIKSLSSFI.................................................................
A0A0V2F1N1_SALNE/1-74                ............................---------------...---.......-----.---.-----....-------------------------....------........----..-........--------------............-----.-----MLAVKTTCKDRWRQILNEAD..R..I..Q..D..IYLFTLQEG.VSVAQFQEMQQERVRLVVPSSL.HD.K.YPK..T..IREYLISLETFI.................................................................
A0A074MHJ0_9BACL/88-257              .....................dirdkdt--------FLEKVSV...LLS.......EYDEH.IIE.LGKSN....TNSRRSRAGKEFEHTVHKLFLMSGI....RFDPQGyi...gqkKFEE..Qg.....lsKIVDSVVPGVLEYH............L---E.KHKCALISMKTSLRERWQEVPEERS..R..TgaH..M..MYLITLDEQ.ISNEIIDSLYEHNVRIVVRDWI.KE.TkYKQ..N..Q--RVLGLRNL-i................................................................
Q9JZ51_NEIMB/218-386                 ............................FSIFEKREF-EIIKS...KIT.......-DLDS.FIN.FAHSF....TNRRKARAGKSLELHLSRIFDEFSL....KFETQA........KTEG..K........KKPDFLFPGSEEYHamd......esgNFIFQ.TEKLTMLGSKTTCKDRWRQVLNEAD..R..I..P..H..KHLFTLQEG.ISDTQIQEMSDENLTLVVPKES.VK.T.FGT..F..GKTHVLTLENFI.................................................................
E2ZD30_9FIRM/107-272                 ............................FRAIEHARYGDVVAG...GFA.......-SVDD.FVI.MANRV....LNRRKSRAGKSLEHHLSAIFDENRI....QYAAQA........VTEG..N........KKPDFLFPSEEAYH............DMTFE.IEKLCTLAAKTTCKDRWRQILNEAD..R..L..R..DesKYLCTMQQG.ISAAQMDEMQAEKVILVVPKAY.HS.A.YPK..E..KRDRIWTLGRFV.................................................................
A0A081BFA0_9RHIZ/229-397             ............................FRRLERRIVAERIRN...GFLqa...deVDVDG.FLS.FSLSV....QNRRKSRAGSALENHLEAIFQGFGI....RYSRGA........ETEN..R........NRPDFLFPGQEEYR............DSSFP.TEHLTMLGSKSTLKDRWRQVLSEAE..R..I..D..Q..KHLLTLEPG.ISEHQTNEMKAKKLQLIVPLNL.QS.T.YRP..S..QRDWLFSVCDFL.................................................................
A4ABD8_9GAMM/233-401                 ............................FRRLEKRVVAERITA...GFVqd...gdIDVDG.FIS.FSLGV....QNRRKSRMGHSFENHLKAVFTAHEI....RYDSQV........VTEK..G........KKPDFVFPGSSQYF............DDRFQ.AELLTMLAAKSTCKDRWPQILPEAE..R..I..E..R..KHLITLEPG.ISRSQTDTMRASNVQLIIPQGL.HS.S.YAN..D..QRSWLWNVENFL.................................................................
A0A0F7HPZ5_9STAP/208-371             ............................FKMLEKQIYKEYITE...PFN.......-ELQP.LLD.FANSA....LNRRKSRAGRSLEHHVNYIFKKYKL....PFDNPG........KTEG..R........KKPDFLLPSTEDYQ............NSEFP.AENLILVGAKTTCKDRWRQVLSEGE..R..V..E..R..KHLITLQQG.ISENQLEEMEAANLQLVVPKPY.HK.Q.YPK..S..FKDKIWTVQQFI.................................................................
S6FF02_AVIPA/112-286                 niqdseeirkrlvnlvgdyathispyiy---------------...---.......-----.--Q.LCLSN....TQSRRSRAGKTFEGIIYYLYEYFNY....SFDSQT........KVGK..KcfsslglgKVVDSILPSVEAFN............ER---.RDKTIIGSMKTTLRERWQEVVEEVS..RsnI..P..N..IYLLTVDDD.ISESKAIQMGTHNIVLVVLDYV.KK.Q.SHL..K..DKRSIIDFETY-f................................................................
A0A0J5L1W0_PLUGE/226-390             ............................FLLVEEMHVLDIIKK...GFN.......-SVDD.FIA.LANSV....SNRRKSRAGKSLELHLEQLFLEHGL...tQFATQS........VTEG..N........KKPDFLFPSSDAYH............DKAFP.DEKLHMLAVKTTCKDRWRQVLNEAD..R..I..Q..N..IHLFTLQEG.VSLAQFKEMQQERVTLVVPSSL.HK.K.YPE..A..VRPELMTLGHFI.................................................................
Q8KAN4_CHLTE/1-74                    ............................---------------...---.......-----.---.-----....-------------------------....------........----..-........--------------............-----.-----MLAVKTTCKDRWRQVLNEAN..R..I..G..K..KHLLTVQQG.ISLNQFREMRAHDVQLVVPADI.IK.L.YHK..D..IRSEIMTLEGFL.................................................................
J0N5F7_9CLOT/217-382                 ............................FREIEHVRYGEVITQ...GFA.......-SVED.FIS.MANQV....LNRRKSRAGKSLEHHLAAIFNGNDI....SYKAQA........VTEG..N........KRPDFIFPSEEAYR............DFDFS.NDRLISLAAKTTCKDRWRQVINEAD..R..LrgK..A..KYLCTLQQG.ISAAQMDEMQAEQVILVVPKPY.IS.T.FPK..D..RQNRIWTVRKFV.................................................................
A0A0Q4B9U9_9EURY/174-345             ...........................y-RAMEHHLIQEDLHK...LSEeiaknnpNAADL.YIS.GAMHY....IQVRKSRAGSSFENHIEALLKSHKI....RYSAQK........PTEN..K........KVPDFIMPSIDLYW............DNSFP.VEGLTMLAAKRSCKERWAQILEEAL..R..M..E..E..RHLITMEPA.ITSNTIAAMCSQKIQLVIPESI.RN.T.YND..T..DMRHIWNVATF-l................................................................
A0A060UZV4_9PROT/236-403             ............................FRTLEKHLLGEKLRS...LTQa....gvEDTEP.FIK.LVQSA....LQRRKSRAGSALENHLEQIFTEHGI....TYTRTG........VTEN..N........LKPDFIFPGIGHYH............DSTFP.ETRLTMLASKSTCKDRWRQILNEAA..R..I..P..D..KHLLTLEPS.ISENQTNEMKAEQVQLVLPRGL.HP.T.YTS..A..QQAWLMGVNTF-t................................................................
A0A132BVQ4_9RHOB/235-403             ............................FRHMEKEVLAERLRA...GFAsg...neVDVDG.FLK.FSLGV....QNRRKSRVGYAFGHHIEAVLQANSV....RYKREA........TTEK..R........NAADFLFPGEEEYT............DLAFP.TARLTMLAAKTTCKDRWRQVLAEAD..R..I..N..E..KHLLTLEPA.ISRTQTDEMRKQSLRLVLPQAI.HQ.S.YHE..D..QQGWLLSVENFL.................................................................
A0A168RC58_9MOLU/82-251              ..........................dk---FEKLNSIDSITS...FCQ.......EFVEH.IYA.LFLSN....TQSRRSRAGKEFETIIQLILTGAGI....AADNQGsvg..kdeFTKRglA........KLVDFVSPSVVEYV............---IN.KRNTLLISAKTTLRERWQEVPEEMN..R..TgaQ..E..IFLITLDEN.ISKEVLFNLYESNVHVVTTKKI.KElK.YSD..N..--PRILSLEELI.................................................................
A0A0S2KHM5_9GAMM/236-403             ............................FRLLERHIVQERLTT...GFGe....ngDDIDE.FIR.FSLSV....QNRRKSRVGHAFENHIEELLRHNGI....RFQRGV........HTEG..S........QKPDFLFPGKNEYH............SPSFP.AERLRMLAAKTTCKERWRQILSEAS..R..I..P..R..KHLITLEPS.ISNEQTAQMIEHNVQLVVPWPV.RA.T.YAS..G..QIEHINTFKDFI.................................................................
A0A0F5EYK8_AVIPA/12-126              ........fdsqtkvgkkcfsslglgkv---------------...---.......-----.---.-----....-------------------------....------........----..-........--VDSILPSVEAFN............ER---.RDKTIIGSMKTTLRERWQEVVEEVS..RsnI..P..N..IYLLTVDDD.ISESKAIQMGTHNIVLVVLDYV.KK.Q.SHL..K..DKRSIIDFETY-f................................................................
A0A139SV32_9GAMM/238-405             ............................YRTFENHLLCEQLQKigqANT.......KDANP.VIK.IVQST....LQRRRSRAGLALENHMEHIFREHDI....TYTRGG........ITEG..R........LKPDFIFPGITHYH............DMAFP.ENSLTMLAAKTTCKDRWRQIRNEAG..R..I..T..V..KHLLTLEPG.ISEHQTREMQTENVQLVLPRNL.HE.F.FMP..A..QQAWLLDVSDFI.................................................................
#=GC seq_cons                        ............................F+.hEchhh.thlpt...GFt........sl-t.Fls.hu.Sl....pNRRKSRAGpuhEpHlptlhptpsl....paspps........hTEs..p........p+PDFlFPuhptYp............s.sas.sppLthLusKTTCKDRWRQVLsEAs..R..l..p..p..KaLlTLptu.ISpsQhcEMpspslpLVVPpsl.+p.o.Yst..p..tpshlholppFl.................................................................
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