GenomeNet

Database: Pfam
Entry: EcoRII-C
LinkDB: EcoRII-C
Original site: EcoRII-C 
#=GF ID   EcoRII-C
#=GF AC   PF09019.8
#=GF DE   EcoRII C terminal
#=GF AU   Mistry J, Sammut SJ
#=GF SE   pdb_1na6
#=GF GA   20.30 20.30;
#=GF TC   20.40 22.30;
#=GF NC   20.20 19.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   R.EcoRII
#=GF RN   [1]
#=GF RM   14659759
#=GF RT   Crystal structure of type IIE restriction endonuclease EcoRII
#=GF RT   reveals an autoinhibition mechanism by a novel effector-binding
#=GF RT   fold. 
#=GF RA   Zhou XE, Wang Y, Reuter M, Mucke M, Kruger DH, Meehan EJ, Chen
#=GF RA   L; 
#=GF RL   J Mol Biol. 2004;335:307-319.
#=GF DR   INTERPRO; IPR015109;
#=GF CC   The C-terminal catalytic domain of the Restriction Endonuclease
#=GF CC   EcoRII has a restriction endonuclease-like fold with a central
#=GF CC   five-stranded mixed beta-sheet surrounded on both sides by
#=GF CC   alpha-helices. It cleaves DNA specifically at single 5' CCWGG
#=GF CC   sites [1].
#=GF SQ   34
#=GS J9ZE30_LEPFM/235-402      AC J9ZE30.1
#=GS A8G987_SERP5/232-396      AC A8G987.1
#=GS E7GQT1_CLOSY/217-382      AC E7GQT1.1
#=GS H6LJ76_ACEWD/228-392      AC H6LJ76.1
#=GS C4ZAA8_EUBR3/216-381      AC C4ZAA8.1
#=GS G2IUA0_PSEUL/237-408      AC G2IUA0.1
#=GS C5BFF1_EDWI9/227-391      AC C5BFF1.2
#=GS A6H1I6_FLAPJ/118-283      AC A6H1I6.1
#=GS D5QBX9_KOMHA/229-397      AC D5QBX9.1
#=GS Q727L4_DESVH/225-389      AC Q727L4.1
#=GS Q0AK57_MARMM/222-391      AC Q0AK57.1
#=GS D3VAD7_XENNA/233-403      AC D3VAD7.1
#=GS F2NVD3_TRES6/217-382      AC F2NVD3.1
#=GS K0IIH6_NITGG/84-247       AC K0IIH6.1
#=GS W8VCB3_YEREN/4-45         AC W8VCB3.1
#=GS B3EB39_GEOLS/231-395      AC B3EB39.1
#=GS R5VI29_9PORP/92-165       AC R5VI29.1
#=GS T1I3N5_RHOPR/237-407      AC T1I3N5.1
#=GS A1WU40_HALHL/231-398      AC A1WU40.1
#=GS A0A0A0Z842_9ENTR/227-391  AC A0A0A0Z842.1
#=GS A8AM36_CITK8/227-391      AC A8AM36.1
#=GS A1A2Y0_BIFAA/83-248       AC A1A2Y0.1
#=GS C4K5I7_HAMD5/230-401      AC C4K5I7.1
#=GS R6ETE5_9FIRM/218-383      AC R6ETE5.1
#=GS R5GVJ7_9BACT/218-381      AC R5GVJ7.1
#=GS Q9JZ51_NEIMB/218-386      AC Q9JZ51.1
#=GS A4ABD8_9GAMM/233-401      AC A4ABD8.1
#=GS L0EBE4_THECK/231-399      AC L0EBE4.1
#=GS H2ISN5_RAHAC/232-396      AC H2ISN5.1
#=GS A5FU96_ACICJ/233-400      AC A5FU96.1
#=GS Q8G4B6_BIFLO/235-405      AC Q8G4B6.1
#=GS Q8KAN4_CHLTE/1-74         AC Q8KAN4.1
#=GS E8SGE7_STAPH/83-249       AC E8SGE7.1
#=GS R7B2S4_9CLOT/217-382      AC R7B2S4.1
J9ZE30_LEPFM/235-402                 ...................FQSVEEAIELPVIRRGFS.......-SVSEFVD.RAQTI....LQRRKSRSGKSLELHLKEIFLEDGLsegrDFSCQA........ESEPGKRPDFIFPSEAAYR......DPSFPSEKLRMLAAKTTCKDRWRQILNEADR..I..Q..V..KHLLTLQDG.VSENQFREMSESGVQLVVPKSL.HDSYPPNIRQNLLTLKDFI........................
A8G987_SERP5/232-396                 ...................FRQIEEIHVLDKIKKGFN.......-SVEEFIE.LANSV....SNRRKSRSGKSLEMHLEKIFLANGL...tTFTTQS........ITEGKKKPDFLFPSGIEYH......NPAYPAENLRMLAVKTTCKDRWRQAINEANR..I..N..N..IHLFTLQEG.VSANQFQEMKDAGVTLVVPEPL.HKKYPEKIRSELVSLSDFI........................
E7GQT1_CLOSY/217-382                 ...................FRELEYARYGDIIKKGFQ.......-SVDEFVK.VANMV....LNRRKSRAGKSLEHHLAAIFDGNKI....EYTAQA........VTEGNKKPDFIFPSQTAYH......DTRFSIDYLVSLAAKTTCKDRWRQVLNEADR..L..R..DksKYLCTLQQG.ISGAQMDEMQAENVVLIVPRPY.IKAYPADRQERIWTLSRFV........................
H6LJ76_ACEWD/228-392                 ...................FRTLEKHLIRERLKTGFE.......DDVDAFIS.FSLSV....QNRRKSRVGQALENHVECLLQNRGI....QYDRTK........ITENKSKPDFIFPSISDYH......NRDFSVERLTMLGAKTTCKDRWRQVLPEAER..I..K..H..KHLLTLEAA.ISENQTEEMIAHNLQLVVPKRL.HQTYSAKQQAWLIDVNEF-f.......................
C4ZAA8_EUBR3/216-381                 ...................FRALEEYRYGDIVRCGFP.......-SVEEFVS.VANSV....LNRRKSRAGKSLEHHLEAIFVANEI....IYDAQP........VTEGKKKPDFLFPSAVAYR......DLTYPVSKLATLAAKTTCKDRWRQILNEANR..L..KdeN..KFLCTLQQG.VSPMQMDEMEAEKVILVVPKPY.ISCYPRDRQDRIWTISRFV........................
G2IUA0_PSEUL/237-408                 ...................FRIYERHLVQDRLRAGFGd....hgDDVDEFIS.FSLSV....QNRRKSRVGHAFEGHLDHLFRLHKL....KFQQGRgk....ghVTENNAKPDFLFPSFTDYN......NPDFPTDNLIMLGAKTTCKDRWRQVLSEAAR..I..P..S..KHLVTLEAA.ISEAQTDEMASHNLKLVIPATV.HATYSEKQKHWLLDLQEFI........................
C5BFF1_EDWI9/227-391                 ...................FLQVEELHVLSVIKTGFS.......-SVDAFIS.LANSV....SNRRKSRSGKSLELHLENIFYEYGL...tEFETQA........VTEGNKKPDFLFPSAKAYH......DDSWPPQKLRMLAVKTTCKDRWRQILNEADR..I..Q..D..IYLFTLQEG.VSITQFREMQEERVRLVVPEKL.HEKYPAEIRGNLISLNDFI........................
A6H1I6_FLAPJ/118-283                 etvkeicgeyagrvfpyiy------------------.......-------R.LSLSN....TQSRRSRAGKSFEAIIYKIYENLGY....EYDSQSkvgrktfdTLGLGKKVDSILPNIKCYA......ERR---NKTIIGTMKTSLRERWQEVAEEIERtkI..P..E..IHLLTADES.IPKSKAQEMANHNIIVVTYEWV.ANSVALKSMKNIISFEEY-l.......................
D5QBX9_KOMHA/229-397                 ...................FRRLERRVVAEKINGGFQca...egADVDGFLA.FSLSV....QNRRKARAGSALENHLEAVFQANGI....RYARGA........ETENRNKPDFLFPGKAAYA......DPIFSADRLTMLGSKSTLKDRWRQVLSEAVR..I..R..K..KHLLTLEPG.ISENQTDEMRVKELQLILPQKL.HATFRPSQQAWLMNVREFI........................
Q727L4_DESVH/225-389                 ...................FRMFERHLVAQRLREGFG.......EDVDAFTG.YALSV....LNRRKARAGKALENHVEQVLKDWGV....PYTREC........RTENNSKPDFIFPGCSEYH......QTNFPQDQLRMLAVKSTCKDRWRQVLAEAAR..V..S..R..KHLLTLEPG.ISVQQTTEMVDHAVQLVIPRGI.QSSFQDAQREELISLGEFV........................
Q0AK57_MARMM/222-391                 ...................FRALERGIVGDRLMLGFLds..rgePDVDAFLK.FSLSV....QNRRKSRAGHALMNHFSKILRAFEI....PFTPEA........TTEKKGAADFLFPSEAAYA......DPGFPSANLRMVAAKTSCKDRWRQVLAEADR..I..K..P..KHLLTLQPK.ISLAQTTEMTDQGIILTLPSPI.HSSFQDDQRASLLTVADL-l.......................
D3VAD7_XENNA/233-403                 ...................FKVYERHEVAKKLSQGFGe....ngNDVDEFIH.FSLSI....QNRRKSRAGFAFENHLNQLFLLHNL....QFQQGSa.....knITENKSKPDFLFPCFSAYH......DKFFPQENLRLLGAKTTCKDRWRQVLAEGDR..V..V..R..KHLITMQPG.ISEQQLAEMKNKSLQLVVPESV.QSLYPVSYANDLQNVMEFI........................
F2NVD3_TRES6/217-382                 ...................FRAIEHDRYGSLIKNGFS.......-DVEKFIE.LANQV....LNRRKSRAGKSLEHHLSSLFKGNSI....TFTPQA........ITEGNKKPDFIFPSIEAYH......DTSFSVVKLASLAAKTTCKDRWRQVLNEADR..L..RsqN..KFLCTLQQG.ISSAQLEEMKSEKVVLVVPERY.IKTYPEKYQQDIWTVKKFI........................
K0IIH6_NITGG/84-247                  ..peieantknqkefvsel------------------.......--LDIFMP.VAVSFefrtSQMRKSRAGTTFEHITVFLLQKCGI....KCERTAk......sVRKKMNRMDIVIPNQEVAL......K---KPDQAKFLSCKHTLRERWKQALPEKNR..N..W..V..MYLITMDDD.IPDQKAKEINDHNLIVYVKDQV.KAKSYLAKKDW--------irklsdl.................
W8VCB3_YEREN/4-45                    ...............sflt------------------.......--------.-----....-------------------------....------........-------------------......-------------------------------..-..-..-..---------.---IQTDEMASKCLQFVLPRGL.HQTYTPAQQTWLMDVATF-t.......................
B3EB39_GEOLS/231-395                 ...................FRTLERHIIGDRLQVGFV.......DDVDGFVT.YSLSV....QNRRKSRAGSSLENHLEVIFNAQGI....QYTRTP........VTENNEKPDFIFPDIIHYR......DPDFDVSKLTMLGVKSTCKDRWRQILSEADR..I..K..S..KHLLTLEPG.ISENQTNQMKRSNLQLVVPSAL.QRTYKTEQQTWLLTFDDFI........................
R5VI29_9PORP/92-165                  ...................FKALEIKIYGDKLKSSFN.......-DMDDLIG.FSNTM....LNRRKSGAGKSLEHHLAQIFTNAGL....RFETQE........MTEGKKKPDFLFP------......-------------------------------..-..-..-..---------.----------------------.-------------------........................
T1I3N5_RHOPR/237-407                 ...................FRTLERYLIADKLSKGFSpkg.ngiVDTDGFLQ.FSLSV....QNRRKSRVGLALENHLEIIFKENGI....RYSRGV........VTENRCKPDFLFPSIVEYR......DPDFAHFNLTMLGVKSTCKDRWRQILSEASR..I..P..A..KHLLTLQPS.ISENQTKEMATENVQLVVPALL.HSTYSSEQQKWLKDLNTFI........................
A1WU40_HALHL/231-398                 ...................FRAYEREIVQERLERGFA.......GDVDEFIR.FSLSV....HNRRKSRVGHAFENHLTELFERHGL....RFEKGGv.....nrVTENKSKPDFLFPGFTEYH......DPQFPNSRLFLLGAKTTCKERWRQVLAEGER..L..K..R..KHLATLEPG.ISRTHTDEMSAHGLQLVVPLPI.HATYSETQRMKIMGIQDFI........................
A0A0A0Z842_9ENTR/227-391             ...................FLLVEELHVLDIIRKGFG.......-SVDEFIA.LANSV....SNRRKSRAGKSLELHLEHLFIEHGL...rHFATQA........ITEGNKKPDFLFPSAGAYH......DTEFPVENLRMLAVKTTCKDRWRQILNEADK..I..H..Q..VHLFTLQEG.VSLAQYREMRESGVRLVVPSSL.HKKYPEAVRAELMTLGAFI........................
A8AM36_CITK8/227-391                 ...................FLLVEEMHVLGIVQSGFG.......-SVNEFIA.LANSV....SNRRKSRAGKSLELHLEQLFNEHGL...kTFETQA........VTEGNKKPDFLFPSAQAYH......DEAFPEQKLRMLAVKTTCKDRWRQILNEADR..I..Q..D..IYLFTLQEG.VSVAQFQEMQQERVRLVVPSSL.HDKYPKAIREYLISLETFI........................
A1A2Y0_BIFAA/83-248                  .fkgmeavdaikkfvsdyp------------------.......---QHIYE.LTLSN....TQSRRSRAGKEFEAIIEMMLIGASI....PTDSQGnvgkqffaQHHLGKLVDFVTPGAIQYS......---IDKQRTVLISAKTTLRERWQEVPEEVTR..TgaP..R..MYLATLDSD.ITENTLNVLYESNITIVTTKEN.RSHYTN---PRVMTFEEMI........................
C4K5I7_HAMD5/230-401                 ...................FRTLESYLIADRLSQGFSgkasvaaVDVDGFLS.FSLSV....QNRRKSRVGLALENHLEVLFSENGL....RYTRTA........VTENKAKPDFLFPGVTEYH......NPAFDPLKLTMPGVKSTCKDRWRQVLAEADR..I..D..N..KHLLTLETE.ISTHQTDEMAAKRLQLVLPRSL.YQTYTPSQQTWLIDVASF-t.......................
R6ETE5_9FIRM/218-383                 ...................FRAIEHARYGETISRGFD.......-SVDSFIT.MANMV....LNRRKSRAGKSLEHHLSAIFDGNSI....AYSAQA........VTEGNKKPDFIFPSQEAYH......NATFPTDRLISLAAKTTCKDRWRQVINEADR..L..R..DrpKYLCTLQQG.ISPAQMDEMQSENVILVVPKPY.ISSYPADRQNRIWTLSQFV........................
R5GVJ7_9BACT/218-381                 ...................FRNFEDKFYRDAYQRPFS.......-CCQDLID.FANSI....LNRRKSRAGKSLEHHLATIFSANRL....HYEQQI........VTEGNKRPDFIFPSGKAYH......DIVFPTKDLVFLGAKTTCKDRWRQILNEANR..I..K..D..KYLFTLQQG.ISKNQLSEMKSEHVTLVVPEAY.RQSFPEEFRANIKSLSSFI........................
Q9JZ51_NEIMB/218-386                 ...................FSIFEKREF-EIIKSKIT.......-DLDSFIN.FAHSF....TNRRKARAGKSLELHLSRIFDEFSL....KFETQA........KTEGKKKPDFLFPGSEEYHamdesgNFIFQTEKLTMLGSKTTCKDRWRQVLNEADR..I..P..H..KHLFTLQEG.ISDTQIQEMSDENLTLVVPKES.VKTFGTFGKTHVLTLENFI........................
A4ABD8_9GAMM/233-401                 ...................FRRLEKRVVAERITAGFVqd...gdIDVDGFIS.FSLGV....QNRRKSRMGHSFENHLKAVFTAHEI....RYDSQV........VTEKGKKPDFVFPGSSQYF......DDRFQAELLTMLAAKSTCKDRWPQILPEAER..I..E..R..KHLITLEPG.ISRSQTDTMRASNVQLIIPQGL.HSSYANDQRSWLWNVENFL........................
L0EBE4_THECK/231-399                 ...................FKRLERHIISKKLEHGFRdn...dsIDVDGFLQ.FSLSV....HNRRKSRVGYALENHLEEIFKIHEI....TYSRTA........ITENKSRPDFLFPGADHYH......DPAFPSERLTMLGVKSTCKDRWRQVLAEADR..I..K..S..KHLLTLEPG.ISENQTDEMQASNLQLVLPQPL.HETYKPRQRCWLINLSDFI........................
H2ISN5_RAHAC/232-396                 ...................FLHIEEFHVLHKIKDGFN.......-SVNEFIA.LANSV....SNRRKSRAGKSLELHLEVIFKDNNL...lDFSTQC........VTEGNKKPDFIFPSGQAYH......DFNYPEEKLRMLAVKTTCKDRWRQAINEADK..I..K..K..VHLFTLQEG.VSVNQFNEMKEAGIILVVPKPL.HEKYPKDIRMELVTLEDFI........................
A5FU96_ACICJ/233-400                 ...................FLSVEEAVYLPRIRQGFS.......-AIGDFLS.LAQTI....LQSRKTRSGTSLELHVREIMTEEGLladtSFTYRP........VIENGKRPDFLFPSKAAYD......NPAFPAERLRMLAAKTTCKDRWRQVLNEADR..I..A..T..KHLLTLQEG.VSEGQFREMSEAGVRLVVPAEL.HRSYPASVRPHLVTFENFI........................
Q8G4B6_BIFLO/235-405                 ...................FKLYERAVIQHDYDAAPFvs..dgvIDVDSFTS.FYTSV....RNRRMSRAGKVLEIHIAHILDARGI....EYEAQA........KTENGKKPDFLFPSQAAYE......DPAFPEEQLRMLASKTSIKDRFRQVADEANR..I..R..D..KHLFTLTPGdVTHPKLAQLDELHIHLVMPKVV.KESYDDLIQGETMTFSRFI........................
Q8KAN4_CHLTE/1-74                    ...................------------------.......--------.-----....-------------------------....------........-------------------......----------MLAVKTTCKDRWRQVLNEANR..I..G..K..KHLLTVQQG.ISLNQFREMRAHDVQLVVPADI.IKLYHKDIRSEIMTLEGFL........................
E8SGE7_STAPH/83-249                  ..lgldniesikwfvenfp------------------.......---DHIYR.LSLSN....TQSRRSRAGKEFEIIIELILMGANI....PFDTQGsigsgvfeSSELAKLVDCVSPGALEYK......---LDKRNTSLISAKTTLRERWQEVGDEMAR..T..KarE..MYLVTLDEN.ITSQTMKLISANNIVIVTTNSIlNDNYKKM------------hgiisveeml..............
R7B2S4_9CLOT/217-382                 ...................FRALEYARYGDIITKGFQ.......-SVDEFVR.VANVV....LNRRKSRAGKSLEHHLSAIFDGNGI....EYSSQA........VTEGNKKPDFLFPSQEAYH......DYDFSTDYIISLAAKTTCKDRWRQVLNEADR..L..R..DkpKYLCTLQQG.ISGAQMDEMQAENVILVVPKPY.IATYPKDRRDRIWTLARFV........................
#=GC seq_cons                        ...................F+tlEchhhhchlppGFs........sVDtFlp.hu.SV....pNRRKSRAG+uLEtHLptlFptpul....pasppu........lTEspcKPDFlFPutttY+......c.tFssppLphLusKTTCKDRWRQlLsEAsR..I..p..p..KHLhTLptG.IStsQhcEMpscslpLVVPpsl.ppoYstp.psplholppFl........................
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