GenomeNet

Database: Pfam
Entry: EcoRII-N
LinkDB: EcoRII-N
Original site: EcoRII-N 
#=GF ID   EcoRII-N
#=GF AC   PF09217.8
#=GF DE   Restriction endonuclease EcoRII, N-terminal
#=GF AU   Sammut SJ
#=GF SE   pdb_1na6
#=GF GA   25.00 25.00;
#=GF TC   25.50 26.30;
#=GF NC   21.10 24.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   R.EcoRII
#=GF RN   [1]
#=GF RM   14659759
#=GF RT   Crystal structure of type IIE restriction endonuclease EcoRII
#=GF RT   reveals an autoinhibition mechanism by a novel effector-binding
#=GF RT   fold. 
#=GF RA   Zhou XE, Wang Y, Reuter M, Mucke M, Kruger DH, Meehan EJ, Chen
#=GF RA   L; 
#=GF RL   J Mol Biol. 2004;335:307-319.
#=GF DR   INTERPRO; IPR023372;
#=GF DR   SCOP; 1na6; fa;
#=GF CC   The N-terminal effector-binding domain of the Restriction
#=GF CC   Endonuclease EcoRII has a DNA recognition fold, allowing for
#=GF CC   binding to 5'-CCWGG sequences. It assumes a structure composed
#=GF CC   of an eight-stranded beta-sheet with the strands in the order of
#=GF CC   b2, b5, b4, b3, b7, b6, b1 and b8. They are mostly antiparallel
#=GF CC   to each other except that b3 is parallel to b7. Alternatively,
#=GF CC   it may also be viewed as consisting of two mini beta-sheets of
#=GF CC   four antiparallel beta-strands, sheet I from beta-strands b2,
#=GF CC   b5, b4, b3 and sheet II from strands b7, b6, b1, b8, folded into
#=GF CC   an open mixed beta-barrel with a novel topology. Sheet I has a
#=GF CC   simple Greek key motif while sheet II does not [1].
#=GF SQ   29
#=GS K2D2K9_9BACT/20-177      AC K2D2K9.1
#=GS J9ZE30_LEPFM/14-167      AC J9ZE30.1
#=GS R5UQ53_9PORP/12-135      AC R5UQ53.1
#=GS B3EB37_GEOLS/3-105       AC B3EB37.1
#=GS F2NVD3_TRES6/12-144      AC F2NVD3.1
#=GS C4ZAA8_AGARV/13-138      AC C4ZAA8.1
#=GS A5P8H9_9SPHN/2-118       AC A5P8H9.1
#=GS H2CIA7_9LEPT/22-162      AC H2CIA7.1
#=GS A0A0E9N2X2_9SPHI/12-102  AC A0A0E9N2X2.1
#=GS A0A0F7HPZ5_9STAP/9-142   AC A0A0F7HPZ5.1
#=GS R7B2S4_9CLOT/15-146      AC R7B2S4.1
#=GS G9RPY3_9FIRM/12-137      AC G9RPY3.1
#=GS A0A0G3UZF9_9ACTN/30-126  AC A0A0G3UZF9.1
#=GS J0N5F7_9CLOT/12-136      AC J0N5F7.1
#=GS R5GVJ7_9BACT/12-144      AC R5GVJ7.1
#=GS A3X5U6_9RHOB/2-97        AC A3X5U6.1
#=GS C5BFF1_EDWI9/13-166      AC C5BFF1.2
#=GS A8G987_SERP5/12-169      AC A8G987.1
#=GS Q9JZ51_NEIMB/26-167      AC Q9JZ51.1
#=GS A8AM36_CITK8/13-166      AC A8AM36.1
#=GS H2ISN5_RAHAC/12-169      AC H2ISN5.1
#=GS A5FU96_ACICJ/14-166      AC A5FU96.1
#=GS D5QBY0_KOMHA/6-115       AC D5QBY0.1
#=GS A9MS72_SALAR/13-166      AC A9MS72.1
#=GS R5UXG0_9PORP/13-149      AC R5UXG0.1
#=GS R6ETE5_9FIRM/14-148      AC R6ETE5.1
#=GS E7GQT1_CLOSY/14-144      AC E7GQT1.1
#=GS E2ZD29_9FIRM/15-79       AC E2ZD29.1
#=GS A0A0A0Z842_9ENTR/12-165  AC A0A0A0Z842.1
K2D2K9_9BACT/20-177                 .....dr--HGMVWFIKRLSGNDTGLTGGHQSGLYIPRDFA.E..LV..APEVCRKDRYN..PEVFIKsCYMPNADFTAENVRVVYYNSKHFPernlkKKYDEFRMTRLGGNSSPFHNIENTGSICVFAVSRTGD.....--ELAAVAWVASSLEEENTIESWLGH.eVDPARMVLSQ---ap..............................
J9ZE30_LEPFM/14-167                 ......s-RRETLWFAKRLSANDTLANNAHQAGPYIPKNIL.F..TL..FPSLDRPEDKN..PEVRFR.LQIDSHQGERREIRAVWYNNRRRG.....KTRDEARITGFGGRSSPFLDPENTGALMLLVVPPGDN.....TQTSICRAWVCRNPSEEDLLEDLIGP..VEPGKGFLWAP--ev..............................
R5UQ53_9PORP/12-135                 ..vdkvq-----AAFCKFIYANDVGATGAHQDGIYIPKNCW.S..LI..FDNPSE-KGVN..KDHFVK.IRWKNNFETD--NRFIYYGK----.....GTRNEYRLTRFGKRFPFFQE-DNVGDLIIICRTE---.....--------------------------..-------------ldyyfgfvlsadedidnffg............
B3EB37_GEOLS/3-105                  ..ysaqi--------TKILSANDVGETGGHQAGILVPKDLEiL..SF..FPSLNS-KEKN..PRVTLV.FREGDG-ITRWDFNFIYYNNRFFG.....GTRNEYRLTCM--------------------------.....--------------------------..-------------tqylrarnakvgdhvvls..............
F2NVD3_TRES6/12-144                 ....tan---SERIFCKFLSANDTGETGGHQSGIYIPKNSV.P..LI..FDTPG-VKGEN..KEEFNK.IKWQDDFETDAHFK--YYGQ----.....GTRNEYRITGFGRNF-PFLKPAFTGSLVIILKQKDSS.....-----YKGYVL---------------..-------------etedeieyfldyfgitpnet............
C4ZAA8_AGARV/13-138                 ...tvas----ELAFCKFLSANDTGATGGHQGGVLVSVSAS.R..ML..FVEILP-DNDI..LKRDVK.ITWQGDLVTESTFT--YYSS----.....--KKELRITKFGRDFDII-NPDRTGSLFVLTKQSWDD.....-----YSVFIMD--------------..-------------tedeieeflstfgi..................
A5P8H9_9SPHN/2-118                  ....gsq------TYEKPLTANDTGETGGHQAGIHIPKSQT.DliAL..LPFLDP-AQKN..PDAWLE.MTDDAG--VTWRFRYIYYNNRLHDe...gGTRDEYRITHMTKFFRAVGA-----------------.....--------------------------..-------------tegdvlvltgspgsltysvsv...........
H2CIA7_9LEPT/22-162                 ...gssd------AYLKFLSPNDLGLTGSHQAGIYLSRESA.P..LF..LEGKTVEKGEN..VEREVR.IRFRGGNV---AARFVWYGK----.....-AKSECRLTRILPLFRPDPA-RLEGSLFILAAVPDDRpdslfENDSLFQCWIIESEDE----------..-------------iravldflgitpaetn................
A0A0E9N2X2_9SPHI/12-102             ....vka---NKISFFKFVSANDAGTTGGHQLGIYIPKKSF.P..LL..FDQPGK-KGQN..MERFVE.INWFDGTVSNACFK--YYGS----.....GTRNEYRITRIGINF----------------------.....--------------------------..-------------tenel...........................
A0A0F7HPZ5_9STAP/9-142              ..rgigc------FFCKFLSANDTGANGSHQTGVYLNMSSW.D..IF..FEGPIP-NNEI..KSRKVK.INFNDE--TEFESRLVYYSS----.....--KKEFRITRFWTN-IFIPHTEMVGALILFIPMHIDE.....-----YKVYIFNTEE--EI-E-----..-------------efietfslslaenhmty...............
R7B2S4_9CLOT/15-146                 .nsekgl--------CKFLSANDTGATGGHQSGILISKSAV.E..MM..FSKQELEQAGI..PKRTVK.VRWQDDFETESCFT--YYES----.....--KNELRITRFGRGF-PFLKPEQTGALFVFTQQTDFD.....----YCGYF-----------------..-------------letdeeieefldtfgisptetns.........
G9RPY3_9FIRM/12-137                 ....alq---GTKVFCKFLSANDTGLTGGHQAGIYISKPSI.P..IL..FDV-PGTKGQN..MEKWVK.IRWMDGNETDS--RFIYYGQ----.....GTRNEYRITNFGRGFPYLR-PDFTGALFVFVQNSSED.....-----YQAFVLNTED-----------..-------------einqfldaf.......................
A0A0G3UZF9_9ACTN/30-126             gqvkris---------KILSRNDLGLTGSHQAGITVPRNPE.F.lVI..FPKLDP-LIKN..PEAKVW.VIAEEIE-YAGHLRFIYYNGKLLG....eGTRNEYRLTGV--------------------------.....--------------------------..-------------tqllrglqam......................
J0N5F7_9CLOT/12-136                 ...alqg----QKVFCKFLSANDTGVTGAHQAGIYISKPSI.P..IL..FDEPGQ-KGQN..KEKWVK.VRWQSDF--ETETRFIYYGQ----.....GTRNEYRITNFGRGFPYL-KPEYTGALFVLVMDNEEY.....--------------------------..-------------yqgfvlntedeinqflds..............
R5GVJ7_9BACT/12-144                 ..vrsar-----LSFCRFITANDTGDTGAHQAGFYIPKCAA.R..LL..FETPGQ-KGEN..KSRTVH.ICWQNDFTTESR--FIYYGR----.....GTRNEYRITRFGRNFPFFQE-SATGDLLIVAQESEDD.....-----YAAFVL--SSDQDI-EDFLA-..-------------hfnldigsl.......................
A3X5U6_9RHOB/2-97                   ...ssek-------FRKRLSANDVGTTGGHQGGVLIPKGEK.E..LLamLPALDP-EVKN..PDAWIE.CTDE--TGHTLKFRFVYYNNRLHDp...gGTRNEYRITHM--------------------------.....--------------------------..-------------tswfrdvga.......................
C5BFF1_EDWI9/13-166                 .....tg---NAYVYIKRLSANDTGATGAHQVGTYMQHSAA.E..YL..FPSINKTDECN..PSLMIT.ARTSSHSYPENQVRVIYYNNKFFG.....KTRNERRITRWGGG-SPLQDTENTGALALLVFDSSLGg...kSDCQSVDVWVCRDADEEDIVEASIGE..ILPGDLIFGLADE................................
A8G987_SERP5/12-169                 ......s-SDNWYIHIKRLSANDTGASGGHQSGVYLPNNSA.N..FL..FPSINRIDEEN..PSVGLT.AKIISHEVNDSQVRAVYYNSKLRNl..npKGRNETRITCWGGQKSPVQNQNNTGAIAIFAFYTPEN....lKDCGLVEAWVCCTVEEEDLLEAIIGE..VLPGTARSGPSA-q...............................
Q9JZ51_NEIMB/26-167                 .......ANKSIAVYCRYIRPNDVGTTGSHQSGFYIQKHFS.D..DL..FDVVCQ-KGTN..KTISIK.INWQDGSVTNSNFK--YYGQ----.....GTRNEARITGFGKNFEFLSD-KYSGSLLVLCRACYKD.....---LLFHAFVL--SSDEDI-EIFIAEtnILPGSLYLPKKQE................................
A8AM36_CITK8/13-166                 ......s-TSDTYMFIKRLSANDTGATGGHQVGIYIPSGIV.E..HL..FPSINHTRDLN..PSVMLN.AHTSSHNCPDSEARAIYYNGRFFG.....KTRNEKRITRWGGGKNPLQDPENTGALALLAFDHHQG.....SDSQFVDIWVCHNAEEEDIVESSLGE..IVPGSLVYGPANE................................
H2ISN5_RAHAC/12-169                 .......GNPEWVIYMKRLSANDTGATGGHQVGIYIPKITR.D..TL..FPSINRVDCDN..PSIPLS.AKIVSHDIEEQTVNAIYYNSKLAKq..qkKGRNESRITSWGGKKSPIQDPENTGSLLILAFKKQTE....lADCMYLEAWICRSIEEEDLLETITGE..ILPGISVFN----sgds............................
A5FU96_ACICJ/14-166                 .....gv--PGAVWFAKRLAANDTLATGAHGAGPYIPKEFL.F..SV..FPDLNHPEEEN..PDCWFD.LYIDSHA-DRRRIRAIWYNNRLRG.....GTRNEARLTNFGGGRSALLDPDSTGALAVFAFLPHGP.....GRQMECHVWVCDQGAEADLLEERIGP..VEPKAPVVWQPG-e...............................
D5QBY0_KOMHA/6-115                  ..fssai--------FKILSKNDSGMGAGHQAGFLIPTELR.-..SF..FPPLPEATIENpaPSILID.AILISDQTQPVRVITRWQAQTWYN.....QRSPETRLTG---------------------------.....--------------------------..-------------eleiirkyscegdllliekseedi........
A9MS72_SALAR/13-166                 ......s-TSDTYMFIKRLSANDTGATGGHQVGIYIPSGIV.E..HL..FPSINHTRDLN..PSVTLN.AHTSSHSCPDTEARAVYYNGRFFG.....KTRNEKRITRWGGGKNPLQNPENTGALALLAFDHRQG.....ADSQFVDIWVCHDAEEEDIVESSLGE..IVPGSLVYGPANE................................
R5UXG0_9PORP/13-149                 ....kra----KIIFLKLITANDTGATGAHQAGFHLPKNSW.R..LF..FDSPG-IKGYN..KDKYIT.IRWGSFS---TESRAIYYGK----.....GTRNEYRLTRFGLHFPYLQE-QNIGDILIIIRNFDDT.....--------------------------..-------------yegfiifkenilsfwmesglsennlntitina
R6ETE5_9FIRM/14-148                 ...lnsr-----KAYCKFLSANDTGLTGGHQAGIYIAKPSV.P..IL..FDEPG-IKGEN..KEKWVK.VKWQDDI--ETDTRFIYYGQ----.....GTRNEYRITNFGRGFPF-LRPEYTGALFVFAKCS-DE.....----YYQAYILN--SEDDI-------..-------------dqfldafgigptetnrl...............
E7GQT1_CLOSY/14-144                 ....lns----IQGFCKFLSANDTGATGGHQSGILISKSAV.E..ML..FTKQQLDQEGI..PKRTVK.IEWQDDLVTESRFT--YYES----.....--KNELRVTRFGRGF-PFLHPDQTGALFVFTKQSEDD.....Y-------------------------..-------------sgyfleteeeieeflnafgisptet.......
E2ZD29_9FIRM/15-79                  ..sggps-------YCKFLSANDSGETGGHQSGILISKSAK.A..ML..WTD--------..------.------------------------.....-------------------------------------.....--------------------------..-------------demrenhilkkygrirwqedyvtdctf.....
A0A0A0Z842_9ENTR/12-165             .....ac--ENYFVYIKRLSANDTGATGGHQVGLYIPSGIV.E..KL..FPSINHTRELN..PSVFLT.AHVSSHDCPDSEARAIYYNSRHFG.....KTRNEKRITRWGRG-SPLQDPENTGALTLLAFKLDEQ....gGDCKEVNIWVCASTDEEDVIETAIGE..VIPGALISGPA--gq..............................
#=GC seq_cons                       .....tp.....hhahKhLSANDTGsTGGHQuGlYIPKssh.t..hL..Fss.s..cspN...chhlc.hphpsp..scsphRhlYYss.........tTRNEhRITpaGtth..h.p.c.oGuLhlhsh...tt..........h.ha................................p...............................
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