GenomeNet

Database: Pfam
Entry: EcoRII-N
LinkDB: EcoRII-N
Original site: EcoRII-N 
#=GF ID   EcoRII-N
#=GF AC   PF09217.5
#=GF DE   Restriction endonuclease EcoRII, N-terminal
#=GF AU   Sammut SJ
#=GF SE   pdb_1na6
#=GF GA   25.00 25.00;
#=GF TC   34.10 33.60;
#=GF NC   24.40 23.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   R.EcoRII
#=GF RN   [1]
#=GF RM   14659759
#=GF RT   Crystal structure of type IIE restriction endonuclease EcoRII
#=GF RT   reveals an autoinhibition mechanism by a novel effector-binding
#=GF RT   fold. 
#=GF RA   Zhou XE, Wang Y, Reuter M, Mucke M, Kruger DH, Meehan EJ, Chen
#=GF RA   L; 
#=GF RL   J Mol Biol. 2004;335:307-319.
#=GF DR   INTERPRO; IPR023372;
#=GF DR   SCOP; 1na6; fa;
#=GF CC   The N-terminal effector-binding domain of the Restriction
#=GF CC   Endonuclease EcoRII has a DNA recognition fold, allowing for
#=GF CC   binding to 5'-CCWGG sequences. It assumes a structure composed
#=GF CC   of an eight-stranded beta-sheet with the strands in the order of
#=GF CC   b2, b5, b4, b3, b7, b6, b1 and b8. They are mostly antiparallel
#=GF CC   to each other except that b3 is parallel to b7. Alternatively,
#=GF CC   it may also be viewed as consisting of two mini beta-sheets of
#=GF CC   four antiparallel beta-strands, sheet I from beta-strands b2,
#=GF CC   b5, b4, b3 and sheet II from strands b7, b6, b1, b8, folded into
#=GF CC   an open mixed beta-barrel with a novel topology. Sheet I has a
#=GF CC   simple Greek key motif while sheet II does not [1].
#=GF SQ   84
#=GS A9MS72_SALAR/12-167  AC A9MS72.1
#=GS F4SU18_ECOLX/11-165  AC F4SU18.1
#=GS F3HNG7_PSEYM/2-109   AC F3HNG7.1
#=GS A9LZL8_NEIM0/24-168  AC A9LZL8.1
#=GS O69414_ECOLX/10-166  AC O69414.1
#=GS O69414_ECOLX/10-166  DR PDB; 3HQF A; 12-168;
#=GS Q0QC82_KLEPN/12-168  AC Q0QC82.1
#=GS H6U1M1_KLEPN/12-167  AC H6U1M1.1
#=GS F0N7B6_NEIMN/24-168  AC F0N7B6.1
#=GS H2CIA7_9LEPT/21-165  AC H2CIA7.1
#=GS A1IS96_NEIMA/24-168  AC A1IS96.1
#=GS D4VIQ1_9BACE/10-152  AC D4VIQ1.1
#=GS F0AGN7_NEIME/24-168  AC F0AGN7.1
#=GS H9TJU2_SALET/12-168  AC H9TJU2.1
#=GS E9ZZS8_NEIME/24-168  AC E9ZZS8.1
#=GS F4SPZ6_ECOLX/10-166  AC F4SPZ6.1
#=GS C4SM52_YERFR/12-167  AC C4SM52.1
#=GS E2ZD29_9FIRM/14-80   AC E2ZD29.1
#=GS A5FU96_ACICJ/12-167  AC A5FU96.1
#=GS Q0ZKQ2_ECOLX/12-168  AC Q0ZKQ2.1
#=GS G5PWS4_SALET/11-166  AC G5PWS4.1
#=GS B6RFM3_KLEPN/10-166  AC B6RFM3.1
#=GS F1ZEW2_ECOLX/11-165  AC F1ZEW2.1
#=GS A3X5U6_9RHOB/2-99    AC A3X5U6.1
#=GS E7JER8_ECOLX/11-165  AC E7JER8.1
#=GS F4UYJ6_ECOLX/11-165  AC F4UYJ6.1
#=GS F0ASQ4_NEIME/21-165  AC F0ASQ4.1
#=GS G9RPY3_9FIRM/10-153  AC G9RPY3.1
#=GS Q9JZ51_NEIMB/24-168  AC Q9JZ51.1
#=GS B0KIU9_PSEPG/2-114   AC B0KIU9.1
#=GS D2T6Y1_ERWP6/10-165  AC D2T6Y1.1
#=GS B5C825_SALET/11-166  AC B5C825.1
#=GS F0B488_NEIME/21-165  AC F0B488.1
#=GS B3X2L5_SHIDY/12-168  AC B3X2L5.1
#=GS I0LXL9_SALET/10-166  AC I0LXL9.1
#=GS B3EB37_GEOLS/2-117   AC B3EB37.1
#=GS H3LHY2_KLEOX/12-168  AC H3LHY2.1
#=GS E9Y3W8_ECOLX/10-166  AC E9Y3W8.1
#=GS I0MW06_SALET/10-166  AC I0MW06.1
#=GS D0FVV3_ERWPE/10-165  AC D0FVV3.1
#=GS F2NVD3_TRES6/10-152  AC F2NVD3.1
#=GS E6MZ36_NEIMH/21-165  AC E6MZ36.1
#=GS C3QIT8_9BACE/10-152  AC C3QIT8.1
#=GS D7RVG4_ECOLX/10-166  AC D7RVG4.1
#=GS E4MC48_9BACT/14-154  AC E4MC48.1
#=GS E2EAW3_KLEPN/10-166  AC E2EAW3.1
#=GS H2ISN5_RAHAC/10-170  AC H2ISN5.1
#=GS A8AM36_CITK8/12-167  AC A8AM36.1
#=GS D7RTV8_KLEOX/12-168  AC D7RTV8.1
#=GS C6SCM6_NEIME/24-168  AC C6SCM6.1
#=GS Q6IVW7_ECOLX/12-168  AC Q6IVW7.1
#=GS D5QBY0_GLUHA/3-143   AC D5QBY0.1
#=GS E3D592_NEIM7/24-168  AC E3D592.1
#=GS I0MY78_SALET/10-166  AC I0MY78.1
#=GS B7NSB9_ECO7I/12-168  AC B7NSB9.1
#=GS H6D9B1_9BACT/10-166  AC H6D9B1.1
#=GS F6IBA5_ECOLX/12-168  AC F6IBA5.1
#=GS F8UZ93_VIBFL/10-40   AC F8UZ93.1
#=GS Q64Q06_BACFR/11-156  AC Q64Q06.1
#=GS D0TX25_9BACE/10-152  AC D0TX25.1
#=GS C4RXK1_YERBE/10-165  AC C4RXK1.1
#=GS G9WEH0_SALET/11-166  AC G9WEH0.1
#=GS C5BFF1_EDWI9/26-182  AC C5BFF1.1
#=GS A8G987_SERP5/10-170  AC A8G987.1
#=GS H5P7W0_ECOLX/10-166  AC H5P7W0.1
#=GS B6UZ62_KLEPN/10-166  AC B6UZ62.1
#=GS E0N8K9_NEIME/24-168  AC E0N8K9.1
#=GS G4PYC5_ECOLX/10-166  AC G4PYC5.1
#=GS A5P8H9_9SPHN/2-118   AC A5P8H9.1
#=GS C4ZAA8_EUBR3/11-147  AC C4ZAA8.1
#=GS H5VQW0_SALSE/11-166  AC H5VQW0.1
#=GS G5QNQ7_SALRU/11-166  AC G5QNQ7.1
#=GS C9QJ40_VIBOR/10-166  AC C9QJ40.1
#=GS T2E2_ECOLX/12-168    AC P14633.2
#=GS T2E2_ECOLX/12-168    DR PDB; 1NA6 A; 12-168;
#=GS T2E2_ECOLX/12-168    DR PDB; 1NA6 B; 12-168;
#=GS D0UIZ0_ERWPY/10-165  AC D0UIZ0.1
#=GS F0MRM6_NEIMM/24-168  AC F0MRM6.1
#=GS F0N1F7_NEIMO/24-168  AC F0N1F7.1
#=GS G0F3L4_ECOLX/10-166  AC G0F3L4.1
#=GS E7BHY7_NEIMW/24-168  AC E7BHY7.1
#=GS H9TJE0_SALET/10-166  AC H9TJE0.1
#=GS F0AAS8_NEIME/24-168  AC F0AAS8.1
#=GS B4TTB4_SALSV/11-166  AC B4TTB4.1
#=GS D4WZ95_BACOV/10-152  AC D4WZ95.1
#=GS E7GQT1_CLOSY/11-154  AC E7GQT1.1
#=GS A9N698_SALPB/11-166  AC A9N698.1
A9MS72_SALAR/12-167             .......k-STSDTYM-FIKRLSANDTGATGGHQVGIYIPSGI.VEH..LFPSINH..TRDLN..PSVTLNAHTSSH.SCPD.TEARAVYYNGRFFG...KTRNEKRITRWGGGKNpLQNPENTGALALLAFD..HRQG.....ADSQFVDIWVCHDAEEEDIVESSLGEIVPGS....LVYGPANEI..................................
F4SU18_ECOLX/11-165             ....kvgg----NNY-LYIKRLSANDTGATGGHQVGIYIPSGI.VAE..LFPSIDH..TSEKN..PSVLLRATYSSH.ECVD.SEVRAIYYNNKYFG...QTRNEKRITRWGAGSP.LQDPENTGALSVLAFE..HEPG.....RDSKSVDVWVCVSPEEEDVLESAVGEIIPGT....LMFGTASEI..................................
F3HNG7_PSEYM/2-109              .....sks---------FIKVLSPNDVGATGAHQGGILIPKSE.ADL..LS-ILPRldPSLKN..PDAWIECVDENG.IV--.RKFRFVYYNNKLHDp.nGTRNEYRITYMTGYFKeL---------------..----.....-------------------------------....---------varegehfeitfikk...................
A9LZL8_NEIM0/24-168             ........QTANKSIAVYCRYIRPNDVGTTGSHQSGFYIQKHF.SDD..LF-DVVC..QKGTN..KTISIKINWQDG.SVTN.S--NFKYYGQ----...GTRNEARITGFGKNFE.FLSDKYSGSLLVLC--..-RAC.....YKDLLFHAFVLSSDEDIEIFIAET-NILPGS....LYLPKKQEV..................................
O69414_ECOLX/10-166             ........EIACENYFVYIKRLSANDTGATGGHQVGLYIPSGI.VEK..LFPSINH..TRELN..PSVFLTAHVSSH.DCPD.SEARAIYYNSRHFG...KTRNEKRITRWGRGSP.LQDPENTGALTLLAFK.lDEQG.....GDCKEVNIWVCASTDEEDVIETAIGEVIPGA....LISGPAGQI..................................
#=GR O69414_ECOLX/10-166  SS    ........HHHTSSEEEEEEE--HHHHTTTS-S--EEEE-HHH.HHH..H-GGG--..SSSSS..-EEEEEEEESSS.----.EEEEEEEE-TTTTT...SS--EEEEE---TTSG.GG-GGGTT-EEEEEEE.--TTS.....S---EEEEEE--SHHHHHHHHHHH----TT-....-EEEEHHHH..................................
Q0QC82_KLEPN/12-168             ........EIACENYFVYIKRLSANDTGATGGHQVGLYIPSGI.VEK..LFPSINH..TRELN..PSVFLTAHVSSH.DCPD.SEARAIYYNSRHFG...KTRNEKRITRWGRGSP.LQDPENTGALTLLAFK.lDEQG.....GDCKEVNIWVCASTDEEDVIETAIGEVIPGA....LISGPAGQI..................................
H6U1M1_KLEPN/12-167             ..kiirgf--------ISVKRLSANDTGATRSHQSGLYMPGAV.IDE..LFPSLRD..TQLRN..PEALFSVHVSSHpDCPDlDDVRAIYYNNKFFG...GTRDEKRLTGFGRQNP.LQNPENTGALALLAFD..HVPG.....TSSSYCDVWVCKDLTEEDILEPIIGEVIPGA....TIFGPGDK-i.................................
F0N7B6_NEIMN/24-168             ........QTANKSIAVYCRYIRPNDVGTTGSHQSGFYIQKHF.SDD..LF-DVVC..QKGTN..KTISIKINWQDG.SVTN.S--NFKYYGQ----...GTRNEARITGFGKNFE.FLSDKYSGSLLVLC--..-RAC.....YKDLLFHAFVLSSDEDIEIFIAET-NILPGS....LYLPKKQEV..................................
H2CIA7_9LEPT/21-165             ...agssd--------AYLKFLSPNDLGLTGSHQAGIYLSRES.APL..FLEGKTV..EKGEN..VEREVRIRFRGG.NVA-.--ARFVWYGK----...-AKSECRLTRILPLFR.PDPARLEGSLFILAAV..PDDRpdslfENDSLFQCWIIESEDEIRAVLDFL-GITPA-....---------etnqrl............................
A1IS96_NEIMA/24-168             ........QTANKSIAVYCRYIRPNDVGTTGSHQSGFYIQKHF.SDD..LF-DVVC..QKGTN..KTISIKINWQDG.SVTN.S--NFKYYGQ----...GTRNEARITGFGKNFE.FLSDKYSGFLLVLC--..-RAC.....YKDLLFHAFVLSSDEDIEIFIAET-NILPGS....LYLPKKQEV..................................
D4VIQ1_9BACE/10-152             ....qsvq----QSKAAWCRFITGNDTGATGSHQAGFYIPKCA.SSL..LF-DEPG..KKGEN..KEKTVQIKWQDD.FTTE.S--CMKYYGQ----...GTRNEYRITRFGRGFP.FFQDDNVGDLLIIA--..---K.....YTEEDYLGYVLSADEDIDGFFAYF-NLAPDE....T--------nqlidvag..........................
F0AGN7_NEIME/24-168             ........QTANKSIAVYCRYIRPNDVGTTGSHQSGFYIQKHF.SDD..LF-DVVC..QKGTN..KTISIKINWQDG.SVTN.S--NFKYYGQ----...GTRNEARITGFGKNFE.FLSDKYSGSLLVLC--..-RAC.....YKDLLFHAFVLSSDEDIEIFIAET-NILPGS....LYLPKKQEV..................................
H9TJU2_SALET/12-168             ........EIACENYFVYIKRLSANDTGATGGHQVGLYIPSGI.VEK..LFPSINH..TRELN..PSVFLTAHVSSH.DCPD.SEARAIYYNSRHFG...KTRNEKRITRWGRGSP.LQNPENTGALTLLAFK.lDEQG.....GDCKEVNIWVCASTDEEDVIETAIGEVIPGA....LISGPAGQI..................................
E9ZZS8_NEIME/24-168             ........QTANKSIAVYCRYIRSNDVGTTGSHQSGFYIQKHF.SDD..LF-DVVC..QKGTN..KTISIKINWQDG.SVTN.S--NFKYYGQ----...GTRNEARITGFGKNFE.FLSDKYSGSLLVLC--..-RAC.....YKDLLFHAFVLSSDEDIEIFIAET-NILPGS....LYLPKKQEV..................................
F4SPZ6_ECOLX/10-166             .......d-IASGNYFIYIKRLSANDTGATGGHQVGLYIPSNI.VEK..LFPSINH..TRELN..PSVFLTAHVSSH.DCPD.TQARAIYYNNRYFG...KTRNEKRITRWGRGSP.LQNPENTGALTILAFR.lNEQN.....TDCSEVDIWVCVNPDEEDIIESAIGEIIPGT....LISGPAGQI..................................
C4SM52_YERFR/12-167             ......dk--SSGEWHIYIKRLSGNDTGATGGHQAGVYIPTEV.IEK..QFSSIVR..TDVKN..PDILLPARISSH.GNIE.SIVRAIYYNNRHFD...GTRNEKRITRWGKGSP.LLNKENTGALTVFAFH..SQPN.....SICDFIDVWLCNSLVEEELLESMTGEIIPDF....SVSGPSNQV..................................
E2ZD29_9FIRM/14-80              ..lsggps---------YCKFLSANDSGETGGHQSGILISKSA.KAM..LWTDDEM..RENHI..LKKYGRIRWQED.YVTD.C-------------...----------------.----------------..----.....-------------------------------....---------tft...............................
A5FU96_ACICJ/12-167             .......e-YGVPGAVWFAKRLAANDTLATGAHGAGPYIPKEF.LFS..VFPDLNH..PEEEN..PDCWFDLYIDSH.-ADR.RRIRAIWYNNRLRG...GTRNEARLTNFGGGRSaLLDPDSTGALAVFAFL..PHGP.....GRQMECHVWVCDQGAEADLLEERIGPVEPKA....PVVWQPGEI..................................
Q0ZKQ2_ECOLX/12-168             ........EIACENYFVYIKRLSANDTGATGGHQVGLYIPSGI.VEK..LFPSINH..TRELN..PSVFLTAHVSSH.DCPD.SEARAIYYNSRHFG...KTRNEKRITRWGRGSP.LQNPENTGALTLLAFK.lDEQG.....GDCKEVNIWVCASTDEEDVIETAIGEVIPGA....LISGPAGQI..................................
G5PWS4_SALET/11-166             .......k-STSDTYM-FIKRLSANDTGATGGHQVGIYIPSGI.VEH..LFPSINH..TRDLN..PSVTLNAHTSSH.SCPD.SEARAVYYNGRFFG...KIRNEKRITRWGGGKNpLQNSENTGALALLAFD..HRQR.....ADSQCVDIWVCHDAEEEDIVESSLGEIVPGS....LVYGPANEI..................................
B6RFM3_KLEPN/10-166             ........EIACENYFVYIKRLSANDTGATGGHQVGLYIPSGI.VEK..LFPSINH..TRELN..PSVFLTAHVSSH.DCPD.SEARAIYYNSRHFG...KTRNEKRITRWGRGSP.LQDPENTGALTLLAFK.lDEQG.....GDCKEVNIWVCASTDEEDVIETAIGEVIPGA....LISGPAGQI..................................
F1ZEW2_ECOLX/11-165             ....kvgg----NNY-LYIKRLSANDTGATGGHQVGVYIPSGI.VGE..LFPSIDH..TSEKN..PSVLLRATYSSH.ECVD.SEVRAIYYNNKYFG...QTRNEKRITRWGAGSP.LQDPENTGALSVLAFE..HEPG.....RDSKSVDVWVCVSPEEEDVLESAVGEIIPGT....LMFGPASEI..................................
A3X5U6_9RHOB/2-99               ....ssek---------FRKRLSANDVGTTGGHQGGVLIPKGE.KEL..LA-MLPAldPEVKN..PDAWIECTDETG.--HT.LKFRFVYYNNRLHDp.gGTRNEYRITHMT----.----------------..----.....-------------------------------....---------swfrdvgare........................
E7JER8_ECOLX/11-165             ....kvgg----NNY-LYIKRLSANDTGATGGHQVGIYIPSGI.VAE..LFPSIDH..TSEKN..PSVLLRATYSSH.ECVD.SEVRAIYYNNKYFG...QTRNEKRITRWGAGSP.LQDPENTGALSVLAFE..HELG.....RDSKSVDVWVCVSPEEEDVLESAVGEIIPGT....LMFGTASEI..................................
F4UYJ6_ECOLX/11-165             ....kvgg----NNY-LYIKRLSANDTGATGGHQVGVYIPSGI.VAE..LFPSIDH..MSEKN..PSVLLRATYSSH.ECVD.SEVRAIYYNNKYFG...QTRNEKRITRWGAGSP.LQDPENTGALSVLAFE..HEPG.....RDSKSVDVWVCVSPEEEDVLESAIGEIIPGA....LMFGPASEI..................................
F0ASQ4_NEIME/21-165             ........QTANKSIAVYCRYIRPNDVGTTGSHQSGFYIQKHF.SDD..LF-DVVC..QKGTN..KTISIKINWQDG.SVTN.S--NFKYYGQ----...GTRNEARITGFGKNFE.FLSDKYSGSLLVLC--..-RAC.....YKDLLFHAFVLSSDEDIEIFIAET-NILPGS....LYLPKKQEV..................................
G9RPY3_9FIRM/10-153             ....qaal----QGTKVFCKFLSANDTGLTGGHQAGIYISKPS.IPI..LF-DVPG..TKGQN..MEKWVKIRWMDG.NETD.S--RFIYYGQ----...GTRNEYRITNFGRGFP.YLRPDFTGALFVFV--..---Q.....NSSEDYQAFVLNTEDEINQFLDAFG------....---------lsatetnrlidvhev...................
Q9JZ51_NEIMB/24-168             ........QTANKSIAVYCRYIRPNDVGTTGSHQSGFYIQKHF.SDD..LF-DVVC..QKGTN..KTISIKINWQDG.SVTN.S--NFKYYGQ----...GTRNEARITGFGKNFE.FLSDKYSGSLLVLC--..-RAC.....YKDLLFHAFVLSSDEDIEIFIAET-NILPGS....LYLPKKQEV..................................
B0KIU9_PSEPG/2-114              ...veqqv----------VKILSANDTGETGGHQAGILVPKEPgLLS..FFPKLDA..-SQYN..PRVHLNFLDDGG.--KF.WEFAFIYYNNALFD...GTRNEYRLTRMTKY--.----------------..----.....-------------------------------....---------irqaglvvgdelilsrnsdrycvsfs........
D2T6Y1_ERWP6/10-165             .......e-KATDEHFLFIKRLSANDTGATGAHQVGLYIPADI.VEM..LFPSINH..CKSAN..PDTFLTARISSH.SCVD.REVRAIYYNNKFFG...KTRNEKRITRWGGDSP.LQDPENTGALSILAFR..KDDA.....ADAQYVDVWVCATAGDEDIVESVTGEVIPGV....FYAGSGN--ki................................
B5C825_SALET/11-166             .......k-STSDTYM-FIKRLSANDTGATGGHQVGIYIPSGI.VEH..LFPSINH..TRDLN..PSVTLNAHTSSH.SCPD.SEARAVYYNGRFFG...KTRNEKRITRWGGGKNpLQISENTGALALLAFD..HRQG.....ADSQCVDIWVCHDAEEEDIVESSLGEIVPGS....LVYGPANEI..................................
F0B488_NEIME/21-165             ........QTANKSIAVYCRYIRPNDVGTTGSHQSGFYIQKHF.SDD..LF-DVVC..QKGTN..KTISIKINWQDG.SVTN.S--NFKYYGQ----...GTRNEARITGFGKNFE.FLSDKYSGSLLVLC--..-RAC.....YKDLLFHAFVLSSDEDIEIFIAET-NILPGS....LYLPKKQEV..................................
B3X2L5_SHIDY/12-168             ........EIACENYFVYIKRLSANDTGATGGHQVGLYIPSGI.VEK..LFPSINH..TRELN..PSVFLTAHVSSH.DCPD.SEARAIYYNSRHFG...KTRNEKRITRWGRGSP.LQNPENTGALTLLAFK.lDEQG.....GDCKEVNIWVCASTDEEDVIETAIGEVIPGA....LISGPAGQI..................................
I0LXL9_SALET/10-166             ........EIACENYFVYIKRLSANDTGATGGHQVGLYIPSGI.VEK..LFPSINH..TRELN..PSVFLTAHVSSH.DCPD.SEARAIYYNSRHFG...KTRNEKRITRWGRGSP.LQNPENTGALTLLAFK.lDEQG.....GDCKEVNIWVCASTDEEDVIETAIGEVIPGA....LISGPAGQI..................................
B3EB37_GEOLS/2-117              ..tysaqi----------TKILSANDVGETGGHQAGILVPKDLeILS..FFPSLNS..-KEKN..PRVTLVFREGDG.-ITR.WDFNFIYYNNRFFG...GTRNEYRLTCMTQYLR.ARNA-KVGDHVVL---..----.....-------------------------------....---------skclegrltvevk.....................
H3LHY2_KLEOX/12-168             ........EIACENYFVYIKRLSANDTGATGGHQVGLYIPSGI.VEK..LFPSINH..TRELN..PSVFLTAHVSSH.DCPD.SEARAIYYNSRHFG...KTRNEKRITRWGRGSP.LQDPENTGALTLLAFK.lDEQG.....GDCKEVNIWVCASTDEEDVIETAIGEVIPGA....LISGPAGQI..................................
E9Y3W8_ECOLX/10-166             .......d-IASGNYFIYIKRLSANDTGATGGHQVGLYIPSNI.VEK..LFPSINH..TRELN..PSVFLTAHVSSH.DCPD.TQARAIYYNNRYFG...KTRNEKRITRWGRGSP.LQNPENTGALTILAFR.lNEQN.....TDCSEVDIWVCVNPDEEDIIESAIGEIIPGT....LISGPAGQI..................................
I0MW06_SALET/10-166             ........EIACENYFVYIKRLSANDTGATGGHQVGLYIPSGI.VEK..LFPSINH..TRELN..PSVFLTAHVSSH.DCPD.SEARAIYYNSRHFG...KTRNEKRITRWGRGSP.LQNPENTGALTLLAFK.lDEQG.....GDCKEVNIWVCASTDEEDVIETAIGEVIPGA....LISGPAGQI..................................
D0FVV3_ERWPE/10-165             .......e-KATDEHFLFIKRLSANDTGATGAHQVGLYIPADI.VEM..LFPSINH..CKSAN..PDTFLTARISSH.SCVD.REVRAIYYNNKFFG...KTRNEKRITRWGGDSP.LQDPENTGALSILAFR..KDDA.....ADAQYVDVWVCATAGDEDIVESVTGEVIPGV....FYAGSGN--ki................................
F2NVD3_TRES6/10-152             ....edta----NSERIFCKFLSANDTGETGGHQSGIYIPKNS.VPL..IF-DTPG..VKGEN..KEEFNKIKWQDD.FETD.A--HFKYYGQ----...GTRNEYRITGFGRNFP.FLKPAFTGSLVIIL--..---K.....QKDSSYKGYVLETEDEIEYFLDYF-GITPNE....---------tnrlidtel.........................
E6MZ36_NEIMH/21-165             ........QTANKSIAVYCRYIRPNDVGTTGSHQSGFYIQKHF.SDD..LF-DVVC..QKGTN..KTISIKINWQDG.SVTN.S--NFKYYGQ----...GTRNEARITGFGKNFE.FLSDKYSGSLLVLC--..-RAC.....YKDLLFHAFVLSSDEDIEIFIAET-NILPGS....LYLPKKQEV..................................
C3QIT8_9BACE/10-152             ....qsvq----QSKAAWCRFITGNDTGATGSHQAGFYIPKCA.SSL..LF-DEPG..KKGEN..KEKTVQIKWQDD.FTTE.S--CMKYYGQ----...GTRNEYRITRFGRGFP.FFQDDNVGDLLIIA--..---K.....YTEEDYLGYVLSADEDIDGFFAYF-NLAPDE....T--------nqlidvag..........................
D7RVG4_ECOLX/10-166             ........EIACENYFVYIKRLSANDTGATGGHQVGLYIPSGI.VEK..LFPSINH..TRELN..PSVFLTAHVSSH.DCPD.SEARAIYYNSRHFG...KTRNEKRITRWGRGSP.LQNPENTGALTLLAFK.lDEQG.....GDCKEVNIWVCASTDEEDVIETAIGEVIPGA....LISGPAGQI..................................
E4MC48_9BACT/14-154             ..vgradk--------AFCKFTAANDAGSTGAHQAGYYMPKSA.WSL..MF-DQPG..VRGEN..KDRTVKIKWQKD.FETE.S--RFIYYGK----...GTRNEYRLTRFGRNFP.YLTEDNVGDLFILC--..---H.....IEGDFYEGYILSADEDIEEFLDTFG-LSPTE....---------tnalinrni.........................
E2EAW3_KLEPN/10-166             ........EIACENYFVYIKRLSANDTGATGGHQVGLYIPSGI.VEK..LFPSINH..TRELN..PSVFLTAHVSSH.DCPD.SEARAIYYNSRHFG...KTRNEKRITRWGRGSP.LQDPENTGALTLLAFK.lDGQG.....GDCKEVNIWVCASTDEEDVIETAIGEVIPGA....LISGPAGQI..................................
H2ISN5_RAHAC/10-170             .......e-KGNPEWVIYMKRLSANDTGATGGHQVGIYIPKIT.RDT..LFPSINR..VDCDN..PSIPLSAKIVSH.DIEE.QTVNAIYYNSKLAKqqkKGRNESRITSWGGKKSpIQDPENTGSLLILAFK.kQTEL.....ADCMYLEAWICRSIEEEDLLETITGEILPGI....SV-------fnsgdsv...........................
A8AM36_CITK8/12-167             .......k-STSDTYM-FIKRLSANDTGATGGHQVGIYIPSGI.VEH..LFPSINH..TRDLN..PSVMLNAHTSSH.NCPD.SEARAIYYNGRFFG...KTRNEKRITRWGGGKNpLQDPENTGALALLAFD..HHQG.....SDSQFVDIWVCHNAEEEDIVESSLGEIVPGS....LVYGPANEI..................................
D7RTV8_KLEOX/12-168             ........EIACENYFVYIKRLSANDTGATGGHQVGLYIPSGI.VEK..LFPSINH..TRELN..PSVFLTAHVSSH.DCPD.SEARAIYYNSRHFG...KTRNEKRITRWGRGSP.LQDPENTGALTLLAFK.lDEQG.....GDCKEVNIWVCASTDEEDVIETAIGEVIPGA....LISGPAGQI..................................
C6SCM6_NEIME/24-168             ........QTANKSIAVYCRYIRPNDVGTTGSHQSGFYIQKHF.SDD..LF-DVVC..QKGTN..KTISIKINWQDG.SVTN.S--NFKYYGQ----...GTRNEARITGFGKNFE.FLSDKYSGSLLVLC--..-RAC.....YKDLLFHAFVLSSDEDIEIFIAET-NILPGS....LYLPKKQEV..................................
Q6IVW7_ECOLX/12-168             ........EIACENYFVYIKRLSANDTGATGGHQVGLYIPSGI.VEK..LFPSINH..TRELN..PSVFLTAHVSSH.DCPD.SEARAIYYNSRHFG...KTRNEKRITRWGRGSP.LQDPENTGALTLLAFK.lDEQG.....GDCKEVNIWVCASTDEEDVIETAIGEVIPGA....LISGPAGQI..................................
D5QBY0_GLUHA/3-143              rtyfssai----------FKILSKNDSGMGAGHQAGFLIPTEL.-RS..FFPPLPE..ATIENpaPSILIDAILISD.QTQP.VRVITRWQAQTWYN...QRSPETRLT--GELEI.IRKYSCEGDLLLIE--..----.....-------------------------------....---------kseediyfqppvyrmtllsrgtqifdeflggign
E3D592_NEIM7/24-168             ........QTANKSIAVYCRYIRSNDVGTTGSHQSGFYIQKHF.SDD..LF-DVVC..QKGTN..KTISIKINWQDG.SVTN.S--NFKYYGQ----...GTRNEARITGFGKNFE.FLSDKYSGSLLVLC--..-RAC.....YKDLLFHAFVLSSDEDIEIFIAET-NILPGS....LYLPKKQEV..................................
I0MY78_SALET/10-166             ........EIACENYFVYIKRLSANDTGATGGHQVGLYIPSGI.VEK..LFPSINH..TRELN..PSVFLTAHVSSH.DCPD.SEARAIYYNSRHFG...KTRNEKRITRWGRGSP.LQNPENTGALTLLAFK.lDEQG.....GDCKEVNIWVCASTDEEDVIETAIGEVIPGA....LISGPAGQI..................................
B7NSB9_ECO7I/12-168             .......d-IASGNYFIYIKRLSANDTGATGGHQVGLYIPSNI.VEK..LFPSINH..TRELN..PSVFLTAHVSSH.DCPD.TQARAIYYNNRYFG...KTRNEKRITRWGRGSP.LQNPENTGALTILAFR.lNEQN.....TDCSEVDIWVCVNPDEEDIIESAIGEIIPGT....LISGPAGQI..................................
H6D9B1_9BACT/10-166             ........EIACENYFVYIKRLSANDTGATGGHQVGLYIPSGI.VEK..LFPSINH..TRELN..PSVFLTAHVSSH.DCPD.SEARAIYYNSRHFG...KTRNEKRITRWGRGSP.LQNPENTGALTLLAFK.lDEQG.....GDCKEVNIWVCASTDEEDVIETAIGEVIPGA....LISGPAGQI..................................
F6IBA5_ECOLX/12-168             ........EIACENYFVYIKRLSANDTGATGGHQVGLYIPSGI.VEK..LFPSINH..TRELN..PSVFLTAHVSSH.DCPD.SEARAIYYNSRHFG...KTRNEKRITRWGRGSP.LQDPENTGALTLLAFK.lDEQG.....GDCKEVNIWVCASTDEEDVIETAIGEVIPGA....LISGPAGQI..................................
F8UZ93_VIBFL/10-40              ........EIACENYFVYIKRLSANDTGATGGHQVGLYI----.---..-------..-----..------------.----.--------------...----------------.----------------..----.....-------------------------------....---------..................................
Q64Q06_BACFR/11-156             ........KIQNAKYA-FCRFITANDTGKNGSHQAGFYIPKCA.AAL..LF-DTPG..VKGEN..KDKMVKVKWQDD.FTTD.S--RFIYYGQ----...GTRNEYRITRFGKGFP.FFEEDNVGDLLIIA--..---Q.....QSEDYYYGFVLQTDQDIDDFFAYF-NLSPEKtnqlIDVTQA---stp...............................
D0TX25_9BACE/10-152             ....qsvq----QSKAAWCRFITGNDTGATGSHQAGFYIPKCA.SSL..LF-DEPG..KKGEN..KEKTVQIKWQDD.FTTE.S--CMKYYGQ----...GTRNEYRITRFGRGFP.FFQDDNVGDLLIIA--..---K.....YTEEDYLGYVLSADEDIDGFFAYF-NLAPDE....T--------nqlidvag..........................
C4RXK1_YERBE/10-165             .......e-KSSGDWHIYIKRLSGNDTGATGAHQAGVYIPAEV.IEK..QFSSIVR..TDIRN..PDIHLPARISSH.GNIE.SIVRAIYYNNRHFD...GTRNEKRITCWGKGSP.LLNKENTGALTIFAFH..SVPN.....NTCDFIDVWLCNSLVEEELLESMTGEVIPGF....SVSGPSNQV..................................
G9WEH0_SALET/11-166             .......k-STSDTYM-FIKRLSANDTGATGGHQVGIYIPSGI.VEH..LFPSINH..TRNLN..PSVTLNAHTSSH.SCPD.TEARAVYYNGRFFG...KTRNEKRITRWGGGRNpLQDPENTGALALLAFD..HRQG.....ADSQCVDIWVCHDAEEEDIVESSLGEIAPGS....LVYGPANEI..................................
C5BFF1_EDWI9/26-182             ....kltg-----NAYVYIKRLSANDTGATGAHQVGTYMQHSA.AEY..LFPSINK..TDECN..PSLMITARTSSH.SYPE.NQVRVIYYNNKFFG...KTRNERRITRWGGGSP.LQDTENTGALALLVFDssLGGK.....SDCQSVDVWVCRDADEEDIVEASIGEILPGD....LIFGLADE-v.................................
A8G987_SERP5/10-170             ........EKSSDNWYIHIKRLSANDTGASGGHQSGVYLPNNS.ANF..LFPSINR..IDEEN..PSVGLTAKIISH.EVND.SQVRAVYYNSKLRNlnpKGRNETRITCWGGQKSpVQNQNNTGAIAIFAFY.tPENL.....KDCGLVEAWVCCTVEEEDLLEAIIGEVLPGT....ARSGPSAQI..................................
H5P7W0_ECOLX/10-166             .......d-IASGNYFIYIKRLSANDTGATGGHQVGLYIPSNI.VEK..LFPSINH..TRELN..PSVFLTAHVSSH.DCPD.TQARAIYYNNRYFG...KTRNEKRITRWGRGSP.LQNPENTGALTILAFR.lNEQN.....TDCSEVDIWVCVNPDEEDIIESAIGEIIPGT....LISGPAGQI..................................
B6UZ62_KLEPN/10-166             ........EIACENYFVYIKRLSANDTGATGGHQVGLYIPSGI.VEK..LFPSINH..TRELN..PSVFLTAHVSSH.DCPD.SEARAIYYNSRHFG...KTRNEKRITRWGRGSP.LQNPENTGALTLLAFK.lDEQG.....GDCKEVNIWVCASTDEEDVIETAIGEVIPGA....LISGPAGQI..................................
E0N8K9_NEIME/24-168             ........QTANKSIAVYCRYIRPNDVGTTGSHQSGFYIQKHF.SDD..LF-DVVC..QKGTN..KTISIKINWQDG.SVTN.S--NFKYYGQ----...GTRNEARITGFGKNFE.FLSDKYSGSLLVLC--..-RAC.....YKDLLFHAFVLSSDEDIEIFIAET-NILPGS....LYLPKKQEV..................................
G4PYC5_ECOLX/10-166             .......d-IASGNYFIYIKRLSANDTGATGGHQVGLYIPSNI.VEK..LFPSINH..TRELN..PSVFLTAHVSSH.DCPD.TQARAIYYNNRYFG...KTRNEKRITRWGRGSP.LQNPENTGALTILAFR.lNEQN.....TDCSEVDIWVCVNPDEEDIIESAIGEIIPGT....LISGPAGQI..................................
A5P8H9_9SPHN/2-118              .....gsq--------TYEKPLTANDTGETGGHQAGIHIPKSQ.TDLiaLLPF-LD..PAQKN..PDAWLEMTDDAG.-VTW.R-FRYIYYNNRLHDe.gGTRDEYRITHMTKFFR.AVG-ATEGDVLVLT--..----.....-------------------------------....---------gspgsltysvsv......................
C4ZAA8_EUBR3/11-147             ......es--TVASELAFCKFLSANDTGATGGHQGGVLVSVSA.SRM..LFVEILP..DNDIL..K-RDVKITWQGD.LVTE.S--TFTYYSS----...--KKELRITKFGRDFD.IINPDRTGSLFVLT--..---K.....QSWDDYSVFIMDTEDEIEEFLSTFG------....---------isatetnclf........................
H5VQW0_SALSE/11-166             .......k-STSDTYM-FIKRLSANDTGATGGHQVGIYIPSGI.VEH..LFPSINH..TRDLN..PSVTLNAHTSSH.SCPD.REVRAVYYNGRFFG...KTRNEKRITRWGGGKNpLQNSENTGALALLAFD..HRQG.....ADSQFIDIWVCHDAEEEDIVESSLGEIVPGS....LVYGPANEI..................................
G5QNQ7_SALRU/11-166             .......k-STSDTYM-FIKRLSANDTGATGGHQVGIYIPSGI.VEH..LFPSINH..TRDLN..PSVTLNAHTSSH.SCPD.SEARAVYYNGRFFG...KTRNEKRITRWGGGKNpLQISENTGALALLAFD..HRQG.....VDSQCVDIWVCHDAEEEDIVESSLGEIVPGS....LVYGPANEI..................................
C9QJ40_VIBOR/10-166             ......sk--DTDSWTFYIKRLSANDTGASGGHQAGIYIPKDN.MVE..LFPSINH..TREKN..PDHHLTAITSSH.NFPT.KQVRAIYYNNKFFD...GTRNEMRVTQWGGRLSpLQDHENTGALCVLAFH..KSQT.....GYCDLVDVWVCRSIDEEDELEELTGEVLPGQ....SIFSPAKQI..................................
T2E2_ECOLX/12-168               ........EIACENYFVYIKRLSANDTGATGGHQVGLYIPSGI.VEK..LFPSINH..TRELN..PSVFLTAHVSSH.DCPD.SEARAIYYNSRHFG...KTRNEKRITRWVEAAH.FRILKITGALTLLAFK.lDEQG.....GDCKEVNIWVCASTDEEDVIETAIGEVIPGA....LISGPAGQI..................................
#=GR T2E2_ECOLX/12-168    SS    ........HHHCSSEEEEEEE--CCCCTTTSSS---EEE-HHH.HHH..H-GGG-S..SSSSS..-EEEEEEEETTT.T---.EEEEEEEE-GGGTT...S---EEEEE---TTSG.GG-GGGTT-EEEEEEE.--TTS.....S---EEEEEE--SHHHHHHHHHHH----TT-....-EEEEHHHH..................................
D0UIZ0_ERWPY/10-165             .......e-KATDEHFLFIKRLSANDTGATGAHQVGLYIPADI.VEM..LFPSINH..CKSAN..PDTFLTARISSH.SCVD.REVRAIYYNNKFFG...KTRNEKRITRWGGDSP.LQDPENTGALSILAFR..KDDA.....ADAQYVDVWVCATAGDEDIVESVTGEVIPGV....FYAGSGN--ki................................
F0MRM6_NEIMM/24-168             ........QTANKSIAVYCRYIRPNDVGTTGSHQSGFYIQKHF.SDD..LF-DVVC..QKGTN..KTISIKINWQDG.SVTN.S--NFKYYGQ----...GTRNEARITGFGKNFE.FLSDKYSGSLLVLC--..-RAC.....YKDLLFHAFVLSSDEDIEIFIAET-NILPGS....LYLPKKQEV..................................
F0N1F7_NEIMO/24-168             ........QTANKSIAVYCRYIRPNDVGTTGSHQSGFYIQKHF.SDD..LF-DVVC..QKGTN..KTISIKINWQDG.SVTN.S--NFKYYGQ----...GTRNEARITGFGKNFE.FLSDKYSGSLLVLC--..-RAC.....YKDLLFHAFVLSSDEDIEIFIAET-NILPGS....LYLPKKQEV..................................
G0F3L4_ECOLX/10-166             .......d-IASGNYFIYIKRLSANDTGATGGHQVGLYIPSNI.VEK..LFPSINH..TRELN..PSVFLTAHVSSH.DCPD.TQARAIYYNNRYFG...KTRNEKRITRWGRGSP.LQNPENTGALTILAFR.lNEQN.....TDCSEVDIWVCVNPDEEDIIESAIGEIIPGT....LISGPAGQI..................................
E7BHY7_NEIMW/24-168             ........QTANKSIAVYCRYIRPNDVGTTGSHQSGFYIQKHF.SDD..LF-DVVC..QKGTN..KTISIKINWQDG.SVTN.S--NFKYYGQ----...GTRNEARITGFGKNFE.FLSDKYSGFLLVLC--..-RAC.....YKDLLFHAFVLSSDEDIEIFIAET-NILPGS....LYLPKKQEV..................................
H9TJE0_SALET/10-166             ........EIACENYFVYIKRLSANDTGATGGHQVGLYIPSGI.VEK..LFPSINH..TRELN..PSVFLTAHVSSH.DCPD.SEARAIYYNSRHFG...KTRNEKRITRWGRGSP.LQNPENTGALTLLAFK.lDEQG.....GDCKEVNIWVCASTDEEDVIETAIGEVIPGA....LISGPAGQI..................................
F0AAS8_NEIME/24-168             ........QTANKSIAVYCRYIRPNDVGTTGSHQSGFYIQKHF.SDD..LF-DVVC..QKGTN..KTISIKINWQDG.SVTN.S--NFKYYGQ----...GTRNEARITGFGKNFE.FLSDKYSGSLLVLC--..-RAC.....YKDLLFHAFVLSSDEDIEIFIAET-NILPGS....LYLPKKQEV..................................
B4TTB4_SALSV/11-166             .......k-STSDTYM-FIKRLSANDTGATGGHQVGIYIPSGI.VEH..LFPSINH..TRDLN..PSVTLNAHTSSH.SCPD.SEARAVYYNGRFFG...KTRNEKRITRWGGGKNpLQISENTGALALLAFD..HRQG.....ADSQCVDIWVCHDAEEEDIVESSLGEIVPGS....LVYGPANEI..................................
D4WZ95_BACOV/10-152             ....qsvq----QSKAAWCRFITGNDTGATGSHQAGFYIPKCA.SSL..LF-DEPG..KKGEN..KEKTVQIKWQDD.FTTE.S--CMKYYGQ----...GTRNEYRITRFGRGFP.FFQDDNVGDLLIIA--..---K.....YTEEDYLGYVLSADEDIDGFFAYF-NLAPDE....T--------nqlidvag..........................
E7GQT1_CLOSY/11-154             ...qsvln-----SIQGFCKFLSANDTGATGGHQSGILISKSA.VEM..LFTKQQL..DQEGI..PKRTVKIEWQDD.LVTE.S--RFTYYES----...--KNELRVTRFGRGFP.FLHPDQTGALFVFT--..---K.....QSEDDYSGYFLETEEEIEEFLNAF-GISPTE....T--------nmlidtgkvq........................
A9N698_SALPB/11-166             .......k-STSDTYM-FIKRLSANDTGATGGHQVGIYIPSGI.VEH..LFPSINH..TRDLN..PSVTLNAHTSSH.SCPD.SEARAVYYNGRFFG...KTRNEKRITRWGGGKNpLQNSENTGALALLAFD..HRQR.....ADSQCVDIWVCHDAEEEDIVESSLGEIVPGS....LVYGPANEI..................................
#=GC SS_cons                    ........HHHCSSEEEEEEE--CCCCTTTSSS--EEEE-HHH.HHH..H-GGG-S..SSSSS..-EEEEEEEETTT.T---.EEEEEEEE-CCCTT...SS--EEEEE---TTSG.GG-GGGTT-EEEEEEE.--TTS.....S---EEEEEE--SHHHHHHHHHHH----TT-....-EEEEHHHH..................................
#=GC seq_cons                   ..........sspshhlYlKRLSANDTGATGGHQsGlYIPpsh.s-c..LFPslsc..s+phN..Polhlps+hsoc.sss-.SphRhlYYNs+has...tTRNEtRITRaG+s.s.l.ss-NTGuLhlLA.....cts.....tcsp.hphaVhsos-E.Dlh.sthGpllPGs....Lh.s.ttpl..................................
//
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