GenomeNet

Database: Pfam
Entry: Endonuc-PvuII
LinkDB: Endonuc-PvuII
Original site: Endonuc-PvuII 
#=GF ID   Endonuc-PvuII
#=GF AC   PF09225.6
#=GF DE   Restriction endonuclease PvuII
#=GF AU   Sammut SJ
#=GF SE   pdb_3pvi
#=GF GA   25.00 25.00;
#=GF TC   25.70 25.10;
#=GF NC   20.70 20.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   9878366
#=GF RT   Asp34 of PvuII endonuclease is directly involved in DNA minor
#=GF RT   groove recognition and indirectly involved in catalysis. 
#=GF RA   Horton JR, Nastri HG, Riggs PD, Cheng X; 
#=GF RL   J Mol Biol. 1998;284:1491-1504.
#=GF RN   [2]
#=GF RM   22638584
#=GF RT   Sequence, structure and functional diversity of PD-(D/E)XK
#=GF RT   phosphodiesterase superfamily.
#=GF RA   Steczkiewicz K, Muszewska A, Knizewski L, Rychlewski L, Ginalski
#=GF RA   K;
#=GF RL   Nucleic Acids Res. 2012;40:7016-7045.
#=GF DR   INTERPRO; IPR015306;
#=GF DR   SCOP; 3pvi; fa;
#=GF CC   Members of this family are predominantly found in prokaryotic
#=GF CC   restriction endonuclease PvuII. They recognise the
#=GF CC   double-stranded DNA sequence 5'-CAGCTG-3' and cleave after G-3,
#=GF CC   resulting in specific double-stranded fragments with terminal
#=GF CC   5'-phosphates [1].
#=GF SQ   39
#=GS D0KFJ3_PECWW/7-160    AC D0KFJ3.1
#=GS B5W9S1_ARTMA/1-126    AC B5W9S1.1
#=GS S3DRY9_SALPT/7-160    AC S3DRY9.1
#=GS Q8KT01_SALCE/7-160    AC Q8KT01.1
#=GS L9LT15_ACIBA/95-248   AC L9LT15.1
#=GS R8I9X5_BACCE/5-167    AC R8I9X5.1
#=GS K0ZU33_9STRE/10-164   AC K0ZU33.1
#=GS W6SLB7_9CYAN/5-158    AC W6SLB7.1
#=GS J8HU37_BACCE/59-157   AC J8HU37.1
#=GS S1G7U6_ECOLX/7-160    AC S1G7U6.1
#=GS T2P2_PROHU/4-157      AC P23657.1
#=GS T2P2_PROHU/4-157      DR PDB; 1H56 B; 4-157;
#=GS T2P2_PROHU/4-157      DR PDB; 1EYU A; 4-157;
#=GS T2P2_PROHU/4-157      DR PDB; 3KSK B; 164-317;
#=GS T2P2_PROHU/4-157      DR PDB; 1H56 A; 4-157;
#=GS T2P2_PROHU/4-157      DR PDB; 1F0O A; 4-157;
#=GS T2P2_PROHU/4-157      DR PDB; 3KSK A; 164-317;
#=GS T2P2_PROHU/4-157      DR PDB; 1F0O B; 4-157;
#=GS T2P2_PROHU/4-157      DR PDB; 1PVI B; 4-157;
#=GS T2P2_PROHU/4-157      DR PDB; 1PVU B; 4-157;
#=GS T2P2_PROHU/4-157      DR PDB; 3PVI A; 4-157;
#=GS T2P2_PROHU/4-157      DR PDB; 1NI0 A; 4-157;
#=GS T2P2_PROHU/4-157      DR PDB; 1K0Z B; 4-157;
#=GS T2P2_PROHU/4-157      DR PDB; 3PVI B; 4-157;
#=GS T2P2_PROHU/4-157      DR PDB; 1PVI A; 4-157;
#=GS T2P2_PROHU/4-157      DR PDB; 1EYU B; 4-157;
#=GS T2P2_PROHU/4-157      DR PDB; 2PVI A; 4-157;
#=GS T2P2_PROHU/4-157      DR PDB; 1NI0 B; 4-157;
#=GS T2P2_PROHU/4-157      DR PDB; 2PVI B; 4-157;
#=GS T2P2_PROHU/4-157      DR PDB; 1PVU A; 4-157;
#=GS T2P2_PROHU/4-157      DR PDB; 1NI0 C; 4-157;
#=GS T2P2_PROHU/4-157      DR PDB; 1K0Z A; 5-157;
#=GS S3DP88_SALPT/7-160    AC S3DP88.1
#=GS R8C293_BACCE/5-167    AC R8C293.1
#=GS V2MYN3_SALET/7-160    AC V2MYN3.1
#=GS L2VH62_ECOLX/7-160    AC L2VH62.1
#=GS E2NFK2_9BACE/1-133    AC E2NFK2.1
#=GS K9XGE0_9CHRO/113-266  AC K9XGE0.1
#=GS S1BVZ9_ECOLX/7-160    AC S1BVZ9.1
#=GS K0ZHZ1_9STRE/10-164   AC K0ZHZ1.1
#=GS S3DS77_SALPT/7-160    AC S3DS77.1
#=GS K9VCS8_9CYAN/109-263  AC K9VCS8.1
#=GS B5BKT8_SALPK/7-160    AC B5BKT8.1
#=GS W6SLC0_9CYAN/5-143    AC W6SLC0.1
#=GS D3PMZ8_MEIRD/75-228   AC D3PMZ8.1
#=GS V2CPW5_SALET/7-160    AC V2CPW5.1
#=GS K1W5A2_ARTPT/5-158    AC K1W5A2.1
#=GS H1WFG5_9CYAN/5-143    AC H1WFG5.1
#=GS A1WNN0_VEREI/11-164   AC A1WNN0.1
#=GS S3ESW7_SALPT/7-160    AC S3ESW7.1
#=GS K0ZUR8_9STRE/10-164   AC K0ZUR8.1
#=GS S3EN15_SALPT/7-160    AC S3EN15.1
#=GS W0F4T8_9SPHI/1-129    AC W0F4T8.1
#=GS K1B1U2_9STRE/10-164   AC K1B1U2.1
#=GS F7JJR5_9FIRM/10-162   AC F7JJR5.1
#=GS K7VYC2_9NOST/113-266  AC K7VYC2.1
#=GS S5GK26_SALET/7-160    AC S5GK26.1
#=GS Q9EZ26_SALPT/7-160    AC Q9EZ26.1
#=GS H9L4U0_SALPA/7-160    AC H9L4U0.1
#=GS H0SKH6_9BRAD/1-72     AC H0SKH6.1
D0KFJ3_PECWW/7-160               ......SDWQKLIDLWPQVEEYQRLANKHGVYDIFQDNGGKLLQVLLLLSLK.VLPGREGNDAQDIT..GTEFELKSVNVELTKS.......FSTHHHMNPSIISKYRKVP.WIFAIY.SNITIRSVYLLMPIELEFFYEKWEGQWHE.RGGRDINNPKIPVKYVMEHGCLLW..........
B5W9S1_ARTMA/1-126               ......----------------------------FQDNGGKLLQVILVTGLQ.IIPGREGNDAKDAD..GNEFELKSVNIALTKS.......FSTHHHINPRIIDKYRQVD.WIFAVY.RGINLLYIYKLTSSDLEYFYRKWEEQWYS.KGGKDINNPKIPLKYVIEHGQLLY..........
S3DRY9_SALPT/7-160               .....q-DWSNLIALWPQVEEHQRLANKHGINDIFQDNGGKLLQVLLLLSLK.VLPGREGNDAVDVT..GTEFELKSVNVELTKS.......FSTHHHMNPTIIAKYRQVP.WVFAIY.SNITIRSVYLLMPDDLEVFYDKWERQWYE.RDGKDINNPKIPVKYVIEYGKLLW..........
Q8KT01_SALCE/7-160               .....q-DWSNLIALWPQVEEYQRLANKHGINDIFQDNGGKLLQVLLLLSLK.VLPGREGNDAVDVT..GTEFELKSVNVELTKS.......FSTHHHMNPTIIAKYRQVP.WVFAIY.SNITIRSVYLLMPDDLEVFYDKWERQWYE.RDGKDINNPKIPVKYVIEYGKLLW..........
L9LT15_ACIBA/95-248              ......SDKETLEAIWPFIRKYQELATKNGINDIFQDNGGKLLQVLLNLDLK.VLEGREGNDAVDES..GQEYELKSLNIELVKG.......FSTHHHMNPVIIAKYRQVP.WIFAIY.KNIELQAIYRLEPEDLEEMYVKWEEKWHR.DGGKDINNPKIPLKYVMEKGKLM-s.........
R8I9X5_BACCE/5-167               ..iked-----VKYLLDLADALQKEATKENIISVFDDGGFRELLLTKIFGLK.KMAGRHGDDGLDEE.tGNQYELKTVNLIDTKGelrfrpgITTCHHVNDEIIKRYRAVSgFLVGIF.YINDPVRIYEVPTKALEPYFTMWENRLKTeKRLEHINNPKISFVDIINNGIL--hy........
K0ZU33_9STRE/10-164              .....k-EIERIEGLWAKLEELRDFAKQYGIDDIFQDNGAKVVQQLIYLYLN.ALPGREGNDATSRRnpTIEWEMKSINLDTTAS......gFSTNHHLNTEILQKYRRVP.WSFAIY.HGITLEAIYVMNARDLEPYFQKWEEKLR-.-TQKDINNPKINVNFVRENGTMIY..........
W6SLB7_9CYAN/5-158               .....p-DKAILDELFPYIQQYQALATKHGINDIFQDNGGKLLQVILVTGLQ.IIPGREGNDAKDAD..GNEFELKSVNIALTKS.......FSTHHHINPRIIDKYRQVD.WIFAVY.RGINLLYIYKLTSSDLEYFYRKWEEKWYS.KGGKDINNPKIPLKYVIEHGQLLY..........
J8HU37_BACCE/59-157              pklqat----------------------------------------------.-PPGTQSIDAISIK..GDRYAIKTVTSKTTSA.......FYGLNEPNSAIEEKQIFEY.VIIVVFnKDITIKAIYEMNWENFL-KHKHWHSRVRA.------------------------wnlsvskavl
S1G7U6_ECOLX/7-160               .....q-DWSNLIALWPQVEEYQRLANKHGINDIFQDNGGKLLQVLLLLSLK.VLPGREGNDAVDVT..GTEFELKSVNVELTKS.......FSTHHHMNPTIIAKYRQVP.WVFAIY.SNITIRSVYLLMPGDLEVFYDKWERQWHE.RDGKDINNPKIPVKYVIENGKLLW..........
T2P2_PROHU/4-157                 .....p-DLNKLLELWPHIQEYQDLALKHGINDIFQDNGGKLLQVLLITGLT.VLPGREGNDAVDNA..GQEYELKSINIDLTKG.......FSTHHHMNPVIIAKYRQVP.WIFAIY.RGIAIEAIYRLEPKDLEFYYDKWERKWYS.DGHKDINNPKIPVKYVMEHGTKIY..........
#=GR T2P2_PROHU/4-157      SS    .....T-THHHHHHHHHHHHHHHHHHHHTT-S-TTSTTHHHHHHHHHHHT-E.E-TTTSSSCEE-TT..S-EEEEEEEETTT-SE.......EE--TTB-HHHHHHHTTS-.EEEEEE.ETTEEEEEEEE-HHHHHHHHHHHHHHHHH.TTS--BSS-EEEHHHHHHHSEEEE..........
S3DP88_SALPT/7-160               .....q-DWSNLIALWPQVEEHQRLANKHGINDIFQDNGGKLLQVLLLLSLK.VLPGREGNDAVDVT..GTEFELKSVNVELTKS.......FSTHHHMNPTIIAKYRQVP.WVFAIY.SNITIRSVYLLMPDDLEVFYDKWERQWYE.RDGKDINNPKIPVKYVIEYGKLLW..........
R8C293_BACCE/5-167               ..iked-----VKYLLDLADALQKEATKENIISVFDDGGFRELLLTKIFGLK.KMAGRHGDDGLDEE.tGNQYELKTVNLIDTKGelrfrpgITTCHHVNDEIIKRYRAVSgFLVGIF.YINDPVRIYEVPTKALEPYFTMWENRLKTeKRLEHINNPKISFVDIINNGIL--hy........
V2MYN3_SALET/7-160               .....q-DWSNLIALWPQVEEYQRLANKHGINDIFQDNGGKLLQVLLLLSLK.VLPGREGNDAVDVT..GTEFELKSVNVELTKS.......FSTHHHMNPTIIAKYRQVP.WVFAIY.SNITIRSVYLLMPDDLEVFYDKWERQWYE.RDGKDINNPKIPVKYVIEYGKLLW..........
L2VH62_ECOLX/7-160               .....q-DWSNLIALWPQVEEYQRLANKHGINDIFQDNGGKLLQVLLLLSLK.VLPGREGNDAVDVT..GTEFELKSVNVELTKS.......FSTHHHMNPTIIAKYRQVP.WVFAIY.SNITIRSVYLLMPGDLEVFYDKWERQWHE.RDGKDINNPKIPVKYVIENGKLLW..........
E2NFK2_9BACE/1-133               .....m----------------------YSINDVFQDNGGKLLQVLMITGLQnLDGSREGNDAVDSE..GNEYELKSVNINLTQS.......FSTNHHLNQHIIDKYRKVD.WIFAVY.KDIELVEIYKMTPEMIEPYYTKWETQYK-.TTGKDINNPKIPLKFVRENGIEIY..........
K9XGE0_9CHRO/113-266             ......SDLERLQTALEAIQELQTLANEYGINDVFQDNGGKVLQVLILLGLR.ISPGCEGNDAIDAE..GHKYELKTINKLLSRS.......VTTHHHLNLDILAKYRAVKaWYIAVY.EGIVLKAIYRVAPTSLESKFSYWESRIF-.EGMKSINNPKIPLALIEKEGKLVY..........
S1BVZ9_ECOLX/7-160               .....q-DWSNLIALWPQVEEYQRLANKHGINDIFQDNGGKLLQVLLLLSLK.VLPGREGNDAVDVT..GTEFELKSVNVELTKS.......FSTHHHMNPTIIAKYRQVP.WVFAIY.SNITIRSVYLLMPGDLEVFYDKWERQWHE.RDGKDINNPKIPVKYVIENGKLLW..........
K0ZHZ1_9STRE/10-164              .....k-EIERIEGLWAKLEELRDFAKQYGIDDIFQDNGAKVVQQLIYLYLN.ALPGREGNDATSRRnpTIEWEMKSINLDTTAS......gFSTNHHLNTEILQKYRRVP.WSFAIY.HGITLEAIYVMNARDLEPYFQKWEEKLR-.-TQKDINNPKINVNFVRENGTMIY..........
S3DS77_SALPT/7-160               .....q-DWSNLIALWPQVEEHQRLANKHGINDIFQDNGGKLLQVLLLLSLK.VLPGREGNDAVDVT..GTEFELKSVNVELTKS.......FSTHHHMNPTIIAKYRQVP.WVFAIY.SNITIRSVYLLMPDDLEVFYDKWERQWYE.RDGKDINNPKIPVKYVIEYGKLLW..........
K9VCS8_9CYAN/109-263             ......SDAKRLENAMKSIQELQNLASEYGIADIFQDNGGKTLQLLILLGLR.ISPGREGNDAIDAE..GKEYELKTINIALNRSg.....gVTTHHHLNEIILEKYRRVEaWYIGLY.EGITLKEIYKLTPEMLEPKFKEWEEKVR-.LRNEPLNNPKIPLKLVKK-GQLVY..........
B5BKT8_SALPK/7-160               .....q-DWSNLIALWPQVEEHQRLANKHGINDIFQDNGGKLLQVLLLLSLK.VLPGREGNDAVDVT..GTEFELKSVNVELTKS.......FSTHHHMNPTIIAKYRQVP.WVFAIY.SNITIRSVYLLMPDDLEVFYDKWERQWYE.RDGKDINNPKIPVKYVIEYGKLLW..........
W6SLC0_9CYAN/5-143               .....p-DKAILDELFPYIQQYQALATKHGINDIFQDNGGKLLQVILVTGLQ.IIPGREGNDAKDAD..GNEFELKSVNIALTKS.......FSTHHHINPRIIDKYRQVD.WIFAVY.RGINLLYIYKLTSSDLEYFYRKWEEKWYS.KGGKDINNP---------------..........
D3PMZ8_MEIRD/75-228              ......TDIAILEALFPYIRRYQILASRYGIADIFQDNGGKLLEILIRTGLK.IVPGREGNDAVDEQ..GQEYEIKSVNVELTRS.......FSTHHHLNPSILDKYRRVR.WIFAVY.RNIELQEIYCLEPQQLERFFSDWERKWRA.QGGKDINNPKIPLRYVQREGRLIY..........
V2CPW5_SALET/7-160               .....q-DWSNLIALWPQVEEYQRLANKHGINDIFQDNGGKLLQVLLLLSLK.VLPGREGNDAVDVT..GTEFELKSVNVELTKS.......FSTHHHMNPTIIAKYRQVP.WVFAIY.SNITIRSVYLLMPDDLEVFYDKWERQWYE.RDGKDINNPKIPVKYVIEYGKLLW..........
K1W5A2_ARTPT/5-158               .....p-DKAILDELFPYIQQYQALATKHGINDIFQDNGGKLLQVILVTGLQ.IIPGREGNDAKDAD..GNEFELKSVNIALTKS.......FSTHHHINPRIIDKYRQVD.WIFAVY.RGINLLYIYKLTSSDLEYFYRKWEEQWYS.KGGKDINNPKIPLKYVIEHGQLLY..........
H1WFG5_9CYAN/5-143               .....p-DKAILDELFPYIQQYQALATKHGINDIFQDNGGKLLQVILVTGLQ.IIPGREGNDAKDAD..GNEFELKSVNIALTKS.......FSTHHHINPRIIDKYRQVD.WIFAVY.RGINLLYIYKLTSSDLEYFYRKWEEKWYS.KGGKDINNP---------------..........
A1WNN0_VEREI/11-164              ......TDKQKFERLFPCIREYQVLASKYKINDIFQDNGGKYLQLLMILGLT.TDGTREGNDAVDSF..GNEYEIKTVNLELQHQ.......FTTHHHMNPAIIAKYRKVD.WYFAAF.KNIELQVIYRLKPDHMESFYARWEKKWHD.DGGKDINNPKIPLAHVMEYGEIIW..........
S3ESW7_SALPT/7-160               .....q-DWSNLIALWPQVEEHQRLANKHGINDIFQDNGGKLLQVLLLLSLK.VLPGREGNDAVDVT..GTEFELKSVNVELTKS.......FSTHHHMNPTIIAKYRQVP.WVFAIY.SNITIRSVYLLMPDDLEVFYDKWERQWYE.RDGKDINNPKIPVKYVIEYGKLLW..........
K0ZUR8_9STRE/10-164              .....k-EIERIEGLWAKLEELRDFAKQYGIDDIFQDNGAKVVQQLIYLYLN.ALPGREGNDATSRRnpTIEWEMKSINLDTTAS......gFSTNHHLNTEILQKYRRVP.WSFAIY.HGITLEAIYVMNARDLEPYFQKWEEKLR-.-TQKDINNPKINVNFVRENGTMIY..........
S3EN15_SALPT/7-160               .....q-DWSNLIALWPQVEEHQRLANKHGINDIFQDNGGKLLQVLLLLSLK.VLPGREGNDAVDVT..GTEFELKSVNVELTKS.......FSTHHHMNPTIIAKYRQVP.WVFAIY.SNITIRSVYLLMPDDLEVFYDKWERQWYE.RDGKDINNPKIPVKYVIEYGKLLW..........
W0F4T8_9SPHI/1-129               ......------------------------MNDIFQDNGGKLLQVLLHTGLK.ILPGREGNDAVDDA..GNEYELKSVNIRLTKS.......FSTHHHMNPTIIKKYRKVD.WIFAVY.EGIELLEIYKLKPAHLEPYYVAWEKKWSA.DGDKDINNPKIPLKYVRLHG----irl.......
K1B1U2_9STRE/10-164              .....k-EIERIEGLWAKLEELRDFAKQYGIDDIFQDNGAKVVQQLIYLYLN.ALPGREGNDATSRRnpTIEWEMKSINLDTTAS......gFSTNHHLNTEILQKYRRVP.WSFAIY.HGITLEAIYVMNARDLEPYFQKWEEKLR-.-TQKDINNPKINVNFVRENGTMIY..........
F7JJR5_9FIRM/10-162              .....a-EIAKIEQLWRNLNELDQMAHAYGISDIFQDNGAKVLQQLIYLNMS.ILPGREGNDCISTS..GTEWEMKSINLETSAS......gFSTNHHTTHDIIAKYRQVP.WTFAIY.YGINLAEMYVMTPEMLEPLYQHWEAKLQ-.-TMTHLNNPKIPVKYVREHGIK--vf........
K7VYC2_9NOST/113-266             ......SDLERLQTALGAIQELQSLANEYGINDVFQDNGGKVLQVLILLGLR.ISPGREGNDAIDAE..KNEYELKTINKLLSKS.......VTTNHHLNLDILAKYRAVKaWYIAVY.EGILLKAIYRVDPTSLETKFSYWESRIR-.GGMESINNPKIPLSLIEKEGELVY..........
S5GK26_SALET/7-160               .....q-DWSNLIALWPQVEEYQRLANKHGINDIFQDNGGKLLQVLLLLSLK.VLPGREGNDAVDVT..GTEFELKSVNVELTKS.......FSTHHHMNPTIIAKYRQVP.WVFAIY.SNITIRSVYLLMPDDLEVFYDKWERQWYE.RDGKDINNPKIPVKYVIEYGKLLW..........
Q9EZ26_SALPT/7-160               .....q-DWSNLIALWPQVEEHQRLANKHGINDIFQDNGGKLLQVLLLLSLK.VLPGREGNDAVDVT..GTEFELKSVNVELTKS.......FSTHHHMNPTIIAKYRQVP.WVFAIY.SNITIRSVYLLMPDDLEVFYDKWERQWYE.RDGKDINNPKIPVKYVIEYGKLLW..........
H9L4U0_SALPA/7-160               .....q-DWSNLIALWPQVEEHQRLANKHGINDIFQDNGGKLLQVLLLLSLK.VLPGREGNDAVDVT..GTEFELKSVNVELTKS.......FSTHHHMNPTIIAKYRQVP.WVFAIY.SNITIRSVYLLMPDDLEVFYDKWERQWYE.RDGKDINNPKIPVKYVIEYGKLLW..........
H0SKH6_9BRAD/1-72                ......----------------------------------------------.--------------..----------------.......------MNPTIIAKYRQVD.WIFAIY.RNIELQRVYKLSPKDLEPYFSKWEEKWRS.DGGKDINNPKIPIKFVKEVGTLVY..........
#=GC SS_cons                     .....T-THHHHHHHHHHHHHHHHHHHHTT-S-TTSTTHHHHHHHHHHHT-E.E-TTTSSSCEE-TT..S-EEEEEEEETTT-SE.......EE--TTB-HHHHHHHTTS-.EEEEEE.ETTEEEEEEEE-HHHHHHHHHHHHHHHHH.TTS--BSS-EEEHHHHHHHSEEEE..........
#=GC seq_cons                    .......DhppL.sLaPplcEaQcLAsKaGINDIFQDNGGKLLQVLLlLuL+.lLPGREGNDAlDss..GsEaELKSVNl-LTKS.......FSTHHHhNPsIIsKYRQVs.WlFAIY.psIslculYhLhPcDLEsaYcKWEcpWap.csGKDINNPKIPlKYVhE.GpLla..........
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