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Database: Pfam
Entry: Exonuc_VIII
LinkDB: Exonuc_VIII
Original site: Exonuc_VIII 
#=GF ID   Exonuc_VIII
#=GF AC   PF06630.10
#=GF DE   Enterobacterial exodeoxyribonuclease VIII
#=GF AU   Moxon SJ
#=GF SE   Pfam-B_11449 (release 9.0)
#=GF GA   25.00 25.00;
#=GF TC   34.00 25.70;
#=GF NC   22.50 21.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   2199308
#=GF RT   Physical analysis of spontaneous and mutagen-induced mutants of
#=GF RT   Escherichia coli K-12 expressing DNA exonuclease VIII activity. 
#=GF RA   Mahajan SK, Chu CC, Willis DK, Templin A, Clark AJ; 
#=GF RL   Genetics 1990;125:261-273.
#=GF DR   INTERPRO; IPR010584;
#=GF CC   This family consists of several Enterobacterial
#=GF CC   exodeoxyribonuclease VIII proteins.
#=GF SQ   24
#=GS A0A085I9M3_9ENTR/2-182   AC A0A085I9M3.1
#=GS W1ECU1_KLEPN/2-194       AC W1ECU1.1
#=GS A0A090V4Q6_ESCVU/2-115   AC A0A090V4Q6.1
#=GS A0A0J5M0Q2_PLUGE/3-127   AC A0A0J5M0Q2.1
#=GS W1HPS0_KLEPN/3-178       AC W1HPS0.1
#=GS I2B9H5_SHIBC/6-107       AC I2B9H5.1
#=GS W1H1L2_KLEPN/2-194       AC W1H1L2.1
#=GS G7LMX3_9GAMM/4-131       AC G7LMX3.1
#=GS W1FZP2_ECOLX/4-173       AC W1FZP2.1
#=GS J2DMA8_KLEPN/3-178       AC J2DMA8.1
#=GS A0A181D366_9ENTR/1-125   AC A0A181D366.1
#=GS A6T894_KLEP7/2-194       AC A6T894.1
#=GS A0A0T7RV20_SALET/14-187  AC A0A0T7RV20.1
#=GS V3TNQ5_SERS3/2-185       AC V3TNQ5.1
#=GS C5BBP6_EDWI9/2-105       AC C5BBP6.1
#=GS RECE_ECOLI/2-178         AC P15032.3
#=GS Q8XF26_SALTY/3-194       AC Q8XF26.1
#=GS A0A090V851_ESCVU/2-102   AC A0A090V851.1
#=GS D4E7I2_SEROD/4-149       AC D4E7I2.1
#=GS W1FZP2_ECOLX/227-304     AC W1FZP2.1
#=GS A0A0T7RUI5_SALET/1-194   AC A0A0T7RUI5.1
#=GS W1HZF9_KLEPN/2-194       AC W1HZF9.1
#=GS A8AHT0_CITK8/3-205       AC A8AHT0.1
#=GS A4WB56_ENT38/2-172       AC A4WB56.1
A0A085I9M3_9ENTR/2-182              ...........................................ef-----FNVVKATQKSGKKDAVI.WRS..AKSEArA.....N.....L.....QLDVD...L....E.DAGIetgRGKDYQKPIRTDFPVFNDLPEEGVVDFTWCERYE.LA.EDQRTWQLKPG-----..-....-..A..APQDTFHQED.V..A..D.NDlTTELMA...E--.ENG-D..RKV--EYSDDEN..........AE-FQLVTMPFRIQLLAQLCAETGHVYHI..SIPRRKELSA.........LEMDMDNTYVQNL....................................................................
W1ECU1_KLEPN/2-194                  ...........................................ey-----FYLIKATQKSGKADAVI.WRT..NKSEArA.....L.....L.....QLDVD...L....E.DAGIetgRGKDYQKPIRTDFPVFNDLPAEGVLDYSWCERYQ.LG.DDGRTWALKPGQ-SPA..DhhidD..A..GVPAEPVSGE.P..V..DaNT.TGDATQ..gETV.ETFGS..D-----EYQNDS..........SALFNVAELPFRTQLLAQYMAEEHHVYHI..SMPHRQELSV.........LEMDTDNAAVQDL....................................................................
A0A090V4Q6_ESCVU/2-115              ...........................................ef-----FYLIKATQKSGKPDGVI.WFS..AKTEA.R.....A.....A....lTLDVE...L....E.EAGIetgRGKDYGKPIRTDFPVVNDLPEESTVDFTWCDRYT.LD.DDGRTWSPVPG---EA..G....A..A..AAP-------.-..-..-.--.------...---.-----..------------..........-----------------------------..----------.........-------------vvnvetqptqpaat......................................................
A0A0J5M0Q2_PLUGE/3-127              .....................................tyaylika----------KAKAASAKSFFC.WFSakSDSRA.D.....R.....Q.....ILDILedaE....I.ETGR...G-ADHQLPIRTNWFVVDDLPEEGVLDDTWCDRYT.LA.DDGASWQKIVA--EPA..-....-..-..----------.-..-..-.--.------...---.-----..------------..........-----------------------------..----------.........-------------pkpapeqeqeqeqpipstplstsdenlty.......................................
W1HPS0_KLEPN/3-178                  ...nypylikakakaneakslfcwfsaksdsraerkildiledae----------------------.---..-----.-.....-.....-.....-----...-....I.NVGR...GAS-HQLPIRTNWLIVDDLPEEGVLDDTWCDRYE.LGgEDGLTWQKIVA---P-..-....-..-..AAAEPQPSSK.P..-..E.ND.I-SPAN...SDE.EDYSN..N----------E..........EALFNLAEMSFRTQLLAQYMADERHVYHI..SIPHRNRLSA.........MEMDTDNHGVQNL....................................................................
I2B9H5_SHIBC/6-107                  ..yyikakaksdakslfcwfsaksdsraereianiledadiatgr----------------------.---..-----.-.....-.....-.....-----...-....-.----...-GTDYQLPQRTGWHAVDDLPREGILDETWCERYT.LSaDDNMTWESIIT-----..-....-..-..----------.-..-..-.--.------...---.-----..------------..........-----------------------------..----------.........-------------dlppatgtdtvn........................................................
W1H1L2_KLEPN/2-194                  ...........................................ey-----FYLIKATQKSGKADAVI.WRT..NKSEArA.....L.....L.....QLDVD...L....E.DAGIetgRGKDYQKPIRTDFPVFNDLPAEGVLDYSWCERYQ.LG.DDGRTWALKPG-QVPA..D....-..-..-----HHIDDaG..VtsE.AV.TGEQVDantTID.AAQGEtvETFGSDEYLDDS..........SALFNVAELPFRAQLLAQYMAEERHVYHI..SMPHRQELSV.........LEMDTDNAAVQDL....................................................................
G7LMX3_9GAMM/4-131                  ........................................fayli---------KAKAKADAKSLFC.WFS..AKSES.R.....G.....NreilnILEDA...E....I.ETGR...-GADYQLPVRTNLPVFDDLPEEGVLDDTWCDRYE.LA.DDGRTWQKIAA-GAPN..S....V..N..IQD-------.-..-..-.--.------...---.-----..------------..........-----------------------------..----------.........-------------dhastagtqptaapgdavggtitidqt.........................................
W1FZP2_ECOLX/4-173                  yaylikakakateaknlfcwfsaksdsraereilniledndiavg----------------------.---..-----.-.....-.....-.....-----...-....-.----...RGADYQLPVRTNWFVVDDLPEESTLDDTWCDRYE.LV.EDQQTWQLKQK---PD..N....E..N..QEASSQQ---.-..-..-.--.------...--K.PET--..SSASVPTSDAPA..........-FLRPISRLRLSQRLIAHLLNDGEE-KEI..SEARHVEIGQ.........MELDDNNLYIQNL....................................................................
J2DMA8_KLEPN/3-178                  ...nypylikakakaneakslfcwfsaksdsraerkildiledae----------------------.---..-----.-.....-.....-.....-----...-....I.NVGR...GAS-HQLPIRTNWLIVDDLPEEGVLDDTWCDRYE.LGgEDGLTWQKIVA---P-..-....-..-..AAAEPQPSSK.P..-..E.ND.I-SPAN...SDE.EDYSN..N----------E..........EALFNLAEMSFRTQLLAQYMADERHVYHI..SIPHRNRLSA.........MEMDTDNHGVQNL....................................................................
A0A181D366_9ENTR/1-125              ...........................................me----FFYVVKATQKSGKEDAVI.WFT..AKSEArA.....N.....L.....QLDVE...L....E.DAGIetgRGKDYAKPVRTDFPVYNDLPEESIVDYTWCKRYE.LQ.DDGRTWLPKAGAESTGvvD....K..T..AAPE------.-..-..-.--.------...---.-----..------------..........-----------------------------..----------.........-------------ptvkvettvesvplenrt..................................................
A6T894_KLEP7/2-194                  ...........................................ey-----FYLIKATQKSGKADAVI.WRT..NKSEArA.....L.....L.....QLDVD...L....E.DAGIetgRGKDYQKPIRTDFPVFNDLPAEGLLDYSWCERYQ.LG.DDGRTWALKPG-QAPA..D....HhiD..NAGVSAEPVS.GelV.dA.NT.TGDAAQ..gETV.ETFGS..D-----EYQDDS..........SALFNVAELPFRAQLLAQYMAEERHVYHI..SMPHRQELSV.........LEMDTDNAAVQDL....................................................................
A0A0T7RV20_SALET/14-187             ........................................vknes----------ARKRLGFKAGFF.WCT..AKKQS.L.....A.....L.....SRGEL...A....MdAAGF...DEADFARPVRVHFPVENDIPPEGVFDTKFCENREpGG.EDGKTLTLIPG----A..A....S..A..VKSDETERAD.G..A..G.TP.AGENG-...-IQ.ESH--..--NPPA-----N..........PQLTVVATLPFRHRVLAQYIGDGEYLYHV..DTGQKKEIAC.........LEMDTQNTTVQNL....................................................................
V3TNQ5_SERS3/2-185                  ........................................nnyaf-------VIKAKAKSDKKSLFC.WFS..AKSDS.RaereiA.....N.....ILEDA...E....I.ETGR...-GTDYLLPVRTNWHVVDDLPDEGVIDDTWCDRYE.LS.EDSLTWKRIPA--PPP..S....V..N..IHDDHATVAA.A..Q..V.EH.SGAQLA...QDT.EQTGT..QSE-PQQDSAVT..........FEQA-------------------------..----------.........-------------tftqrvlgawlyskftalgpqglrdiatlqhdmdaaypqnl...........................
C5BBP6_EDWI9/2-105                  ........................................setfa------FLTKAKKKSGKPDMMF.WCS..ATNERiA.....R.....S.....KLSIA...L....D.AAGL...DEADYFNPQRTHLPVVDDLPPEDVLSSDFCRHYQ.ME.DNNWVRRQEPL---P-..-....-..-..----------.-..-..-.--.------...---.-----..------------..........-----------------------------..----------.........-------------paktappsgepq........................................................
RECE_ECOLI/2-178                    .............................................STKPLFLLRKAKKSSGEPDVVL.WAS..NDFES.T.....C.....A.....TLDYL...I....V.KSGK...KLSSYFKAVATNFPVVNDLPAEGEIDFTWSERYQ.LS.KDSMTWELKPG-----..-....-..-..AAPDNAH-YQ.G..N..T.NV.NGEDMT...EIE.ENM--..------------..........--LLPISGQELPIRWLAQH-GSEKPVTHVsrDGLQALHIARaeelpavtaLAVSHKTSLLDPL....................................................................
Q8XF26_SALTY/3-194                  .............................................GTNPVFLVRKAKKSSGQKDAVL.WCS..DDFEA.A.....N.....A.....TLDYL...L....I.KSGA...KLKDYFKAVATNFPVVNELPPEGELSLTFCDYYQ.LA.KDNMTWTQIPGVTLPS..S....E..A..AAAARQHIVD.G..V..D.TE.TGEVLE...DHT.ENFGN..ESNSPAQATAPA..........PELTVVATMPLRHRVLAQYIGEGEYLYHV..DASQKKEILR.........LEMDTDNSYVQNL....................................................................
A0A090V851_ESCVU/2-102              .........................................ntya------FVIKAKAKSEKKNLFC.WLS..AKSDS.R.....AereilN.....ILDDA...D....I.AIGR...-GADYQLPQRTNWHVADDLPEEGILDDTWCDRYT.LG.EDGRSWCPVLG-----..-....-..-..----------.-..-..-.--.------...---.-----..------------..........-----------------------------..----------.........-------------eaggtatp............................................................
D4E7I2_SEROD/4-149                  ......................................vaaylyr----------SKQKSGKSHLFThFEA..KSDDH.A.....E.....T.....KRDYL...F....M.EAGY...SKADYFAPVRIDFPVVDELPAEGEFSETFWLTWA.LE.----------------..-....-..-..----------.-..-..-.--.------...---.-----..------------..........-----------------------------..----------.........-------------saasktcvprdtldpsvafpklypymvkaagdagaeengrstakpqvvqeqqkpageylatnldkhtv
W1FZP2_ECOLX/227-304                ....................rtqtvqewindkkarivgdeptvpp----------------------.---..-----.-.....-.....-.....-----...-....-.----...----------------------------------.--.----------------..-....-..-..----------.-..-..-.--.------...---.-----..----------VT..........PELITVATLPLRQRLLAQFI-SDKYAYHI..DTEQKKTIQE.........LELDVDNSYVQNL....................................................................
A0A0T7RUI5_SALET/1-194              ...........................................me----FFYVVKATQKSGKQDATV.WFT..AKSEArA.....N.....L.....MLDVV...LedaeI.ETG-...RGKDYARPIRTNFPVVNELPPEGEISFTFTNYYR.LG.EDGMTWEQIPGVTLPS..S....E..A..AAAARQHIVD.G..V..D.TE.TGEVLE...DHT.ENFGN..ESNSPAQATAPA..........PELTVVATMPLRHRVLAQYIGEGEYLYHV..DASQKKEILR.........LEMDTDNSYVQNL....................................................................
W1HZF9_KLEPN/2-194                  ...........................................ey-----FYLIKATQKSGKADAVI.WRT..NKSEArA.....L.....L.....QLDVD...L....E.DAGIetgRGKDYQKPIRTDFPVFNDLPAEGVLDYSWCERYQ.LS.DDGRTWALKPG-QVPA..D....H..HidDAGVSAEPVS.GelV.dA.NN.TGDVAQ...DETvETFGS..DEY-----QDDS..........SALFNVAELPFRAQLLAQYMAEERHVYHI..SMSHRQELSV.........LEMDTDNAAVQDL....................................................................
A8AHT0_CITK8/3-205                  .............................................GTNPVFLVRKAKKSSGQKDAVL.WCS..DDLEA.A.....N.....A.....TLDYL...L....I.KSGA...KLKDYFKAVATNFPVVNELPPEGELSLTFCDFYQ.LG.SDNMTWAQIPGVTLPS..S....D..A..AAEARQHIVN.G..V..D.TE.TGEVLE...DHT.EEVVD.tETGEITQHEQPStedngdrpehPQLTVVATMPFRHRVLAQHIGDGEYLYHV..DEEQKKAILA.........LEMDTDNSYVQNL....................................................................
A4WB56_ENT38/2-172                  ...........................................ef-----FNLIKATQKSGKPDGII.WFS..AKTDS.R.....A.....S....lLLDVA...L....E.DAGIetgRGNDYNKPVRTDFPVFNDLPEEGVLDFGWCTRYE.LG.EDARTWYPKAK-----..-....-..-..IANDKAE---.-..-..-.NE.NSVTSA...ATD.TNI--..EPPAPAVDT---..........--TVPVENRNQGVRF-AIHLMNDKYQTHI..SKDQQVAASE.........LVLEEGNTYLHN-l...................................................................
#=GC seq_cons                       ............................................h.......lhKApp+SGptshhh.Who..scs-u.t.....t............LDh....h......csGh...cupDYttPlRTsaPVhsDLPtEGlLD.TWC-RYp.Lu.-DuhTWp.hsu...s...............ts.................................t..............................h.l.t.....ph.A.h..ptt..hcl..s..pt.th...........h.hp.ts.hlps.....................................................................
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