GenomeNet

Database: Pfam
Entry: FYVE
LinkDB: FYVE
Original site: FYVE 
#=GF ID   FYVE
#=GF AC   PF01363.20
#=GF DE   FYVE zinc finger
#=GF AU   Bateman A, Armstrong J
#=GF SE   Pfam-B_655 (release 3.0)
#=GF GA   27.80 27.80;
#=GF TC   27.80 27.80;
#=GF NC   27.70 27.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   FYVE_domain
#=GF RC   Discovery of the FYVE finger
#=GF RN   [1]
#=GF RM   8798641
#=GF RT   Endosomal localization of the autoantigen EEA1 is mediated by a
#=GF RT   zinc-binding FYVE finger. 
#=GF RA   Stenmark H, Aasland R, Toh BH, D'Arrigo A; 
#=GF RL   J Biol Chem 1996;271:24048-24054.
#=GF RN   [2]
#=GF RM   9697764
#=GF RT   FYVE fingers bind PtdIns(3)P. 
#=GF RA   Gaullier JM, Simonsen A, D'Arrigo A, Bremnes B, Stenmark H,
#=GF RA   Aasland R; 
#=GF RL   Nature 1998;394:432-433.
#=GF RN   [3]
#=GF RM   10564636
#=GF RT   FYVE-finger proteins - effectors of an inositol lipid. 
#=GF RA   Stenmark H, Aasland R; 
#=GF RL   J Cell Sci 1999;112:4175-4183.
#=GF DR   INTERPRO; IPR000306;
#=GF DR   SCOP; 1vfy; fa;
#=GF DR   HOMSTRAD; FYVE;
#=GF CC   The FYVE zinc finger is named after four proteins that it has
#=GF CC   been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1. The FYVE
#=GF CC   finger has been shown to bind two Zn++ ions [1]. The FYVE finger
#=GF CC   has eight potential zinc coordinating cysteine positions.  Many
#=GF CC   members of this family also include two histidines in a motif
#=GF CC   R+HHC+XCG, where + represents a charged residue and X any
#=GF CC   residue.  We have included members which do not conserve these
#=GF CC   histidine residues but are clearly related.
#=GF SQ   10654
#=GS C5XYL4_SORBI/218-286        AC C5XYL4.1
#=GS A0A0R4IU58_DANRE/562-626    AC A0A0R4IU58.1
#=GS T1LXP6_TRIUA/3-66           AC T1LXP6.1
#=GS A0A0C9WB75_9HOMO/170-233    AC A0A0C9WB75.1
#=GS A0A158QZV3_NIPBR/340-410    AC A0A158QZV3.1
#=GS B4NNF9_DROWI/187-253        AC B4NNF9.1
#=GS M5WQM8_PRUPE/31-103         AC M5WQM8.1
#=GS A0A067EVB2_CITSI/421-490    AC A0A067EVB2.1
#=GS F6PXN5_MONDO/710-775        AC F6PXN5.1
#=GS H2FLM3_CAEEL/3285-3351      AC H2FLM3.1
#=GS Q23D13_TETTS/22-88          AC Q23D13.2
#=GS A0A0E0N803_ORYRU/420-488    AC A0A0E0N803.1
#=GS W5M8V6_LEPOC/279-354        AC W5M8V6.1
#=GS S7MSW5_MYOBR/710-775        AC S7MSW5.1
#=GS J9BIQ0_WUCBA/253-317        AC J9BIQ0.1
#=GS T0QNY9_9STRA/138-206        AC T0QNY9.1
#=GS A0A0V1LQF6_9BILA/823-888    AC A0A0V1LQF6.1
#=GS A4HYB5_LEIIN/385-553        AC A4HYB5.1
#=GS H3GD75_PHYRM/113-177        AC H3GD75.1
#=GS A0A074YNV1_9PEZI/8-106      AC A0A074YNV1.1
#=GS A0A024GKT8_9STRA/368-437    AC A0A024GKT8.1
#=GS A0A077Z329_TRITR/498-562    AC A0A077Z329.1
#=GS K1QRH8_CRAGI/101-167        AC K1QRH8.1
#=GS A0A024U8Y6_9STRA/791-855    AC A0A024U8Y6.1
#=GS W2YDQ0_PHYPR/295-363        AC W2YDQ0.1
#=GS A0A0M3K378_ANISI/334-398    AC A0A0M3K378.1
#=GS A3GH95_PICST/538-694        AC A3GH95.2
#=GS E9EQL1_METRA/166-229        AC E9EQL1.2
#=GS A0A0K0D5T7_ANGCA/277-347    AC A0A0K0D5T7.1
#=GS A0A0V0W761_9BILA/2573-2639  AC A0A0V0W761.1
#=GS A0A166VAI8_9HOMO/568-683    AC A0A166VAI8.1
#=GS M0VWG0_HORVD/5-68           AC M0VWG0.1
#=GS A0A0D9ZT74_9ORYZ/495-563    AC A0A0D9ZT74.1
#=GS A0A091JFT6_9AVES/1-59       AC A0A091JFT6.1
#=GS A0A087Y7J9_POEFO/279-354    AC A0A087Y7J9.2
#=GS A0A0N4V9L6_ENTVE/636-703    AC A0A0N4V9L6.1
#=GS A0A0A1NGM5_9FUNG/95-158     AC A0A0A1NGM5.1
#=GS R9AV38_WALI9/759-825        AC R9AV38.1
#=GS W2ZVC1_PHYPR/392-457        AC W2ZVC1.1
#=GS U4UGJ3_DENPD/402-504        AC U4UGJ3.1
#=GS A0A024GJM2_9STRA/446-511    AC A0A024GJM2.1
#=GS A0A0D3BH17_BRAOL/132-200    AC A0A0D3BH17.1
#=GS V8NRW5_OPHHA/20-86          AC V8NRW5.1
#=GS H3BHJ6_LATCH/469-535        AC H3BHJ6.1
#=GS B4QG36_DROSI/528-593        AC B4QG36.1
#=GS C5G1C8_ARTOC/138-210        AC C5G1C8.1
#=GS K3WUK0_PYTUL/29-101         AC K3WUK0.1
#=GS A0A059BSW2_EUCGR/624-692    AC A0A059BSW2.1
#=GS A0A0A1P624_9FUNG/484-552    AC A0A0A1P624.1
#=GS A0A091WJ50_OPIHO/234-308    AC A0A091WJ50.1
#=GS A0A135UYJ3_9PEZI/155-229    AC A0A135UYJ3.1
#=GS S3CC23_OPHP1/360-457        AC S3CC23.1
#=GS A0A183SIG3_SCHSO/308-382    AC A0A183SIG3.1
#=GS T0S0S4_9STRA/267-333        AC T0S0S4.1
#=GS A0A093PPW0_9PASS/838-902    AC A0A093PPW0.1
#=GS D0P4C3_PHYIT/141-209        AC D0P4C3.1
#=GS L1IW37_GUITH/116-186        AC L1IW37.1
#=GS A0A132A792_SARSC/365-431    AC A0A132A792.1
#=GS W2Z3P2_PHYPR/610-671        AC W2Z3P2.1
#=GS I3K227_ORENI/719-784        AC I3K227.1
#=GS W6QP20_PENRF/182-305        AC W6QP20.1
#=GS Q4D2Q1_TRYCC/9-75           AC Q4D2Q1.1
#=GS J3M6Q1_ORYBR/654-722        AC J3M6Q1.1
#=GS A0A058Z247_9EUKA/25-90      AC A0A058Z247.1
#=GS E3M6Q1_CAERE/155-217        AC E3M6Q1.1
#=GS A0A067CBC9_SAPPC/467-531    AC A0A067CBC9.1
#=GS A0A091FZL1_9AVES/1095-1157  AC A0A091FZL1.1
#=GS M4BW56_HYAAE/294-372        AC M4BW56.1
#=GS V9E7J6_PHYPR/179-245        AC V9E7J6.1
#=GS A0A0L6WVH9_9AGAR/170-233    AC A0A0L6WVH9.1
#=GS V7CAY8_PHAVU/6-69           AC V7CAY8.1
#=GS V9EJP2_PHYPR/146-214        AC V9EJP2.1
#=GS G0VH05_NAUCC/228-313        AC G0VH05.1
#=GS H0X4J7_OTOGA/866-930        AC H0X4J7.1
#=GS H2TA55_TAKRU/17-83          AC H2TA55.1
#=GS B2WKU5_PYRTR/188-269        AC B2WKU5.1
#=GS U5D4V2_AMBTC/622-690        AC U5D4V2.1
#=GS A0A183BQD3_GLOPA/310-377    AC A0A183BQD3.1
#=GS W6PVV0_PENRF/370-454        AC W6PVV0.1
#=GS E9G458_DAPPU/552-616        AC E9G458.1
#=GS A0A024TUR4_9STRA/293-356    AC A0A024TUR4.1
#=GS T0QLD8_9STRA/115-178        AC T0QLD8.1
#=GS W2YBP1_PHYPR/376-440        AC W2YBP1.1
#=GS A0A091U5Q3_PHORB/1222-1287  AC A0A091U5Q3.1
#=GS K1RIB5_CRAGI/33-100         AC K1RIB5.1
#=GS A0A084G6G8_9PEZI/162-234    AC A0A084G6G8.1
#=GS H0WXA2_OTOGA/527-587        AC H0WXA2.1
#=GS EEA1_HUMAN/1347-1411        AC Q15075.2
#=GS EEA1_HUMAN/1347-1411        DR PDB; 1HYI A; 1-65;
#=GS EEA1_HUMAN/1347-1411        DR PDB; 1JOC B; 1347-1411;
#=GS EEA1_HUMAN/1347-1411        DR PDB; 1HYJ A; 1-65;
#=GS EEA1_HUMAN/1347-1411        DR PDB; 1JOC A; 1347-1411;
#=GS F7A4J2_HORSE/279-353        AC F7A4J2.1
#=GS H3BXK3_TETNG/467-526        AC H3BXK3.1
#=GS A0A0G4J3D8_PLABS/83-149     AC A0A0G4J3D8.1
#=GS M4DGT2_BRARP/613-681        AC M4DGT2.1
#=GS M4DYE9_BRARP/43-115         AC M4DYE9.1
#=GS A0A0V1PJV4_9BILA/2568-2634  AC A0A0V1PJV4.1
#=GS C1N8V0_MICPC/103-180        AC C1N8V0.1
#=GS F7HXA1_CALJA/157-220        AC F7HXA1.1
#=GS L5JZP4_PTEAL/164-230        AC L5JZP4.1
#=GS G1R7Q5_NOMLE/170-236        AC G1R7Q5.2
#=GS S7ZIY6_PENO1/502-567        AC S7ZIY6.1
#=GS K1X937_MARBU/334-417        AC K1X937.1
#=GS H2QE29_PANTR/116-179        AC H2QE29.1
#=GS Q7SEY1_NEUCR/457-522        AC Q7SEY1.1
#=GS M1CRF7_SOLTU/377-445        AC M1CRF7.1
#=GS F1Q5L9_DANRE/900-964        AC F1Q5L9.1
#=GS W2YBK8_PHYPR/108-171        AC W2YBK8.1
#=GS A0A0B0ME14_GOSAR/29-101     AC A0A0B0ME14.1
#=GS D0P252_PHYIT/176-242        AC D0P252.1
#=GS A4HEZ7_LEIBR/1153-1274      AC A4HEZ7.2
#=GS B0W4C2_CULQU/696-751        AC B0W4C2.1
#=GS F7E9C0_CALJA/206-280        AC F7E9C0.1
#=GS A0A0E0PZ18_ORYRU/229-296    AC A0A0E0PZ18.1
#=GS A0A178DV05_9PLEO/350-431    AC A0A178DV05.1
#=GS A0A0A0AMQ1_CHAVO/719-783    AC A0A0A0AMQ1.1
#=GS A0A0V0UEJ8_9BILA/1969-2032  AC A0A0V0UEJ8.1
#=GS A0A0A1MYC9_9FUNG/15-81      AC A0A0A1MYC9.1
#=GS A0A072URJ9_MEDTR/8-71       AC A0A072URJ9.1
#=GS A0A0A1N1E6_9FUNG/20-70      AC A0A0A1N1E6.1
#=GS G8ZWR7_TORDC/484-558        AC G8ZWR7.1
#=GS G1LMY2_AILME/1118-1186      AC G1LMY2.1
#=GS G3JGK7_CORMM/330-415        AC G3JGK7.1
#=GS E4ZJ06_LEPMJ/194-294        AC E4ZJ06.1
#=GS E4X398_OIKDI/160-223        AC E4X398.1
#=GS A0A101MIH2_9EURO/163-226    AC A0A101MIH2.1
#=GS K3WM22_PYTUL/268-330        AC K3WM22.1
#=GS G1NFM7_MELGA/1348-1412      AC G1NFM7.2
#=GS A0A091PHW4_LEPDC/1223-1288  AC A0A091PHW4.1
#=GS A0A0L7LG16_9NEOP/1413-1496  AC A0A0L7LG16.1
#=GS A0A0K9QAS9_SPIOL/16-78      AC A0A0K9QAS9.1
#=GS A0A0E0LNE9_ORYPU/7-70       AC A0A0E0LNE9.1
#=GS A0A066WGM5_9HOMO/390-489    AC A0A066WGM5.1
#=GS W2PNM4_PHYPN/284-349        AC W2PNM4.1
#=GS A0A067CF86_SAPPC/26-92      AC A0A067CF86.1
#=GS G3W6B0_SARHA/216-282        AC G3W6B0.1
#=GS H3GPT0_PHYRM/298-364        AC H3GPT0.1
#=GS W4HBE5_9STRA/502-568        AC W4HBE5.1
#=GS I3KMD9_ORENI/338-409        AC I3KMD9.1
#=GS G5BL44_HETGA/147-213        AC G5BL44.1
#=GS A0A158Q321_DRAME/737-804    AC A0A158Q321.1
#=GS A0A0W8BLQ4_PHYNI/68-133     AC A0A0W8BLQ4.1
#=GS G3N025_BOVIN/593-660        AC G3N025.1
#=GS Q4WYP4_ASPFU/335-419        AC Q4WYP4.1
#=GS G1NT98_MYOLU/593-659        AC G1NT98.1
#=GS F7E858_CALJA/1168-1232      AC F7E858.1
#=GS A0A078AVX8_STYLE/405-470    AC A0A078AVX8.1
#=GS A0A0W8DH59_PHYNI/361-427    AC A0A0W8DH59.1
#=GS W5LJ85_ASTMX/44-109         AC W5LJ85.1
#=GS F6TD27_HORSE/339-411        AC F6TD27.1
#=GS A0A0R3TLG8_HYMNN/3508-3574  AC A0A0R3TLG8.3
#=GS Q6EUF2_ORYSJ/218-286        AC Q6EUF2.1
#=GS A0A077Z3X9_TRITR/58-124     AC A0A077Z3X9.1
#=GS F6ZKX0_HORSE/534-598        AC F6ZKX0.1
#=GS G3QD14_GORGO/570-634        AC G3QD14.1
#=GS A0E0C6_PARTE/18-83          AC A0E0C6.1
#=GS W2PNF8_PHYPN/259-332        AC W2PNF8.1
#=GS A0A093JCU2_FULGA/147-213    AC A0A093JCU2.1
#=GS G3PF96_GASAC/1791-1858      AC G3PF96.1
#=GS E3RQL4_PYRTT/166-229        AC E3RQL4.1
#=GS W2YDI2_PHYPR/340-452        AC W2YDI2.1
#=GS H2UUQ0_TAKRU/1073-1139      AC H2UUQ0.1
#=GS W4H6L0_9STRA/372-430        AC W4H6L0.1
#=GS A0A0C3J4P0_PISTI/200-313    AC A0A0C3J4P0.1
#=GS A0A135SQ99_9PEZI/178-250    AC A0A135SQ99.1
#=GS A0A0A0M3A5_CUCSA/31-103     AC A0A0A0M3A5.1
#=GS A0A0E9NJG5_9ASCO/244-316    AC A0A0E9NJG5.1
#=GS A0A096LZ06_POEFO/92-157     AC A0A096LZ06.1
#=GS A0A0B2SGT5_GLYSO/407-473    AC A0A0B2SGT5.1
#=GS W5LRY2_ASTMX/149-214        AC W5LRY2.1
#=GS A0A183KFT6_9TREM/450-515    AC A0A183KFT6.1
#=GS A0A0L0DUN7_THETB/510-576    AC A0A0L0DUN7.1
#=GS A0A095AGY5_SCHHA/440-505    AC A0A095AGY5.1
#=GS A5DBI8_PICGU/250-341        AC A5DBI8.2
#=GS H2TWH5_TAKRU/148-264        AC H2TWH5.1
#=GS B4LKS5_DROVI/187-253        AC B4LKS5.1
#=GS H0VR83_CAVPO/147-213        AC H0VR83.1
#=GS A0A087XMT2_POEFO/331-403    AC A0A087XMT2.2
#=GS I3KS77_ORENI/695-760        AC I3KS77.1
#=GS G1NYT4_MYOLU/740-804        AC G1NYT4.1
#=GS A0A087YIS3_POEFO/1809-1874  AC A0A087YIS3.2
#=GS A0A087XY87_POEFO/1824-1890  AC A0A087XY87.2
#=GS R7VNG4_COLLI/1212-1277      AC R7VNG4.1
#=GS L5M0Z5_MYODS/1224-1286      AC L5M0Z5.1
#=GS L5MDU3_MYODS/1141-1207      AC L5MDU3.1
#=GS K3XUR4_SETIT/31-102         AC K3XUR4.1
#=GS H0YD93_HUMAN/549-613        AC H0YD93.1
#=GS G4VTD8_SCHMA/157-220        AC G4VTD8.1
#=GS A0A091MY04_9PASS/146-209    AC A0A091MY04.1
#=GS A0A096NWB3_PAPAN/813-877    AC A0A096NWB3.1
#=GS V4T3F2_9ROSI/627-695        AC V4T3F2.1
#=GS A0A061GUS0_THECC/654-722    AC A0A061GUS0.1
#=GS A0A151N553_ALLMI/131-194    AC A0A151N553.1
#=GS G4ZCS8_PHYSP/11-61          AC G4ZCS8.1
#=GS B4NIW9_DROWI/1060-1126      AC B4NIW9.2
#=GS A0A0C3HE73_9PEZI/335-416    AC A0A0C3HE73.1
#=GS A0A081CHN0_PSEA2/173-234    AC A0A081CHN0.1
#=GS A0A093JAG5_PICPB/147-213    AC A0A093JAG5.1
#=GS A0A0V0RZU3_9BILA/128-193    AC A0A0V0RZU3.1
#=GS A0A0R3QFW2_9BILA/160-212    AC A0A0R3QFW2.1
#=GS W7AIB5_PLAVN/30-96          AC W7AIB5.1
#=GS M2MS67_BAUCO/168-231        AC M2MS67.1
#=GS A0A091N4J0_9PASS/1349-1413  AC A0A091N4J0.1
#=GS A0A0H5S7P9_BRUMA/971-1035   AC A0A0H5S7P9.1
#=GS A0A0F8B598_LARCR/375-458    AC A0A0F8B598.1
#=GS L8FS27_PSED2/142-214        AC L8FS27.1
#=GS A0A162NQW7_MUCCL/140-212    AC A0A162NQW7.1
#=GS A0A091HAI6_BUCRH/679-744    AC A0A091HAI6.1
#=GS M4E4N7_BRARP/589-657        AC M4E4N7.1
#=GS I3ME90_ICTTR/2821-2887      AC I3ME90.1
#=GS B4K5Z8_DROMO/669-737        AC B4K5Z8.2
#=GS E2RRY0_CANLF/741-804        AC E2RRY0.2
#=GS X6NR80_RETFI/182-229        AC X6NR80.1
#=GS G6DB47_DANPL/131-197        AC G6DB47.1
#=GS M7YMG6_TRIUA/625-693        AC M7YMG6.1
#=GS T0QLL1_9STRA/123-187        AC T0QLL1.1
#=GS A0A183JH71_9TREM/39-113     AC A0A183JH71.1
#=GS K3X630_PYTUL/1346-1410      AC K3X630.1
#=GS H3AHZ4_LATCH/193-258        AC H3AHZ4.1
#=GS C3YPL0_BRAFL/153-265        AC C3YPL0.1
#=GS A0A093J411_FULGA/715-758    AC A0A093J411.1
#=GS W2YP21_PHYPR/318-397        AC W2YP21.1
#=GS I3K3H3_ORENI/41-107         AC I3K3H3.1
#=GS A0A0J8QTQ6_COCIT/334-418    AC A0A0J8QTQ6.1
#=GS B4I8L8_DROSE/621-686        AC B4I8L8.1
#=GS A0A151XF79_9HYME/498-563    AC A0A151XF79.1
#=GS G3VL22_SARHA/1102-1164      AC G3VL22.1
#=GS A0A0G2K2S8_RAT/554-618      AC A0A0G2K2S8.1
#=GS M0XDD8_HORVD/436-518        AC M0XDD8.1
#=GS A0A024WHR7_PLAFA/31-97      AC A0A024WHR7.1
#=GS Q23VE6_TETTS/45-109         AC Q23VE6.3
#=GS M7CEU6_CHEMY/147-213        AC M7CEU6.1
#=GS A0A0P1ARW5_9STRA/187-251    AC A0A0P1ARW5.1
#=GS W2QXJ1_PHYPN/25-93          AC W2QXJ1.1
#=GS W4G0I3_9STRA/24-89          AC W4G0I3.1
#=GS A0A0V0U1Y5_9BILA/128-193    AC A0A0V0U1Y5.1
#=GS H2UMZ0_TAKRU/603-670        AC H2UMZ0.1
#=GS W6L408_9TRYP/179-348        AC W6L408.1
#=GS W6UHZ9_ECHGR/162-287        AC W6UHZ9.1
#=GS A0A0N7L459_9STRA/284-349    AC A0A0N7L459.1
#=GS A0A0S7DED8_9EURO/490-555    AC A0A0S7DED8.1
#=GS F1MD79_BOVIN/1112-1174      AC F1MD79.2
#=GS HRS_DROME/156-219           AC Q960X8.1
#=GS HRS_DROME/156-219           DR PDB; 1DVP A; 156-219;
#=GS A0A091SAC8_NESNO/186-260    AC A0A091SAC8.1
#=GS H2WD53_CAEJA/793-862        AC H2WD53.2
#=GS A0A091WJH5_NIPNI/147-213    AC A0A091WJH5.1
#=GS W5LDG8_ASTMX/157-220        AC W5LDG8.1
#=GS B6JXN3_SCHJY/14-105         AC B6JXN3.1
#=GS M4DSL8_BRARP/644-710        AC M4DSL8.1
#=GS A0A0N4XF34_NIPBR/3-59       AC A0A0N4XF34.1
#=GS A0A078C1J0_BRANA/37-112     AC A0A078C1J0.1
#=GS A0A093PR42_9PASS/352-417    AC A0A093PR42.1
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