#=GF ID FYVE
#=GF AC PF01363.20
#=GF DE FYVE zinc finger
#=GF AU Bateman A, Armstrong J
#=GF SE Pfam-B_655 (release 3.0)
#=GF GA 27.80 27.80;
#=GF TC 27.80 27.80;
#=GF NC 27.70 27.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF WK FYVE_domain
#=GF RC Discovery of the FYVE finger
#=GF RN [1]
#=GF RM 8798641
#=GF RT Endosomal localization of the autoantigen EEA1 is mediated by a
#=GF RT zinc-binding FYVE finger.
#=GF RA Stenmark H, Aasland R, Toh BH, D'Arrigo A;
#=GF RL J Biol Chem 1996;271:24048-24054.
#=GF RN [2]
#=GF RM 9697764
#=GF RT FYVE fingers bind PtdIns(3)P.
#=GF RA Gaullier JM, Simonsen A, D'Arrigo A, Bremnes B, Stenmark H,
#=GF RA Aasland R;
#=GF RL Nature 1998;394:432-433.
#=GF RN [3]
#=GF RM 10564636
#=GF RT FYVE-finger proteins - effectors of an inositol lipid.
#=GF RA Stenmark H, Aasland R;
#=GF RL J Cell Sci 1999;112:4175-4183.
#=GF DR INTERPRO; IPR000306;
#=GF DR SCOP; 1vfy; fa;
#=GF DR HOMSTRAD; FYVE;
#=GF CC The FYVE zinc finger is named after four proteins that it has
#=GF CC been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1. The FYVE
#=GF CC finger has been shown to bind two Zn++ ions [1]. The FYVE finger
#=GF CC has eight potential zinc coordinating cysteine positions. Many
#=GF CC members of this family also include two histidines in a motif
#=GF CC R+HHC+XCG, where + represents a charged residue and X any
#=GF CC residue. We have included members which do not conserve these
#=GF CC histidine residues but are clearly related.
#=GF SQ 10654
#=GS C5XYL4_SORBI/218-286 AC C5XYL4.1
#=GS A0A0R4IU58_DANRE/562-626 AC A0A0R4IU58.1
#=GS T1LXP6_TRIUA/3-66 AC T1LXP6.1
#=GS A0A0C9WB75_9HOMO/170-233 AC A0A0C9WB75.1
#=GS A0A158QZV3_NIPBR/340-410 AC A0A158QZV3.1
#=GS B4NNF9_DROWI/187-253 AC B4NNF9.1
#=GS M5WQM8_PRUPE/31-103 AC M5WQM8.1
#=GS A0A067EVB2_CITSI/421-490 AC A0A067EVB2.1
#=GS F6PXN5_MONDO/710-775 AC F6PXN5.1
#=GS H2FLM3_CAEEL/3285-3351 AC H2FLM3.1
#=GS Q23D13_TETTS/22-88 AC Q23D13.2
#=GS A0A0E0N803_ORYRU/420-488 AC A0A0E0N803.1
#=GS W5M8V6_LEPOC/279-354 AC W5M8V6.1
#=GS S7MSW5_MYOBR/710-775 AC S7MSW5.1
#=GS J9BIQ0_WUCBA/253-317 AC J9BIQ0.1
#=GS T0QNY9_9STRA/138-206 AC T0QNY9.1
#=GS A0A0V1LQF6_9BILA/823-888 AC A0A0V1LQF6.1
#=GS A4HYB5_LEIIN/385-553 AC A4HYB5.1
#=GS H3GD75_PHYRM/113-177 AC H3GD75.1
#=GS A0A074YNV1_9PEZI/8-106 AC A0A074YNV1.1
#=GS A0A024GKT8_9STRA/368-437 AC A0A024GKT8.1
#=GS A0A077Z329_TRITR/498-562 AC A0A077Z329.1
#=GS K1QRH8_CRAGI/101-167 AC K1QRH8.1
#=GS A0A024U8Y6_9STRA/791-855 AC A0A024U8Y6.1
#=GS W2YDQ0_PHYPR/295-363 AC W2YDQ0.1
#=GS A0A0M3K378_ANISI/334-398 AC A0A0M3K378.1
#=GS A3GH95_PICST/538-694 AC A3GH95.2
#=GS E9EQL1_METRA/166-229 AC E9EQL1.2
#=GS A0A0K0D5T7_ANGCA/277-347 AC A0A0K0D5T7.1
#=GS A0A0V0W761_9BILA/2573-2639 AC A0A0V0W761.1
#=GS A0A166VAI8_9HOMO/568-683 AC A0A166VAI8.1
#=GS M0VWG0_HORVD/5-68 AC M0VWG0.1
#=GS A0A0D9ZT74_9ORYZ/495-563 AC A0A0D9ZT74.1
#=GS A0A091JFT6_9AVES/1-59 AC A0A091JFT6.1
#=GS A0A087Y7J9_POEFO/279-354 AC A0A087Y7J9.2
#=GS A0A0N4V9L6_ENTVE/636-703 AC A0A0N4V9L6.1
#=GS A0A0A1NGM5_9FUNG/95-158 AC A0A0A1NGM5.1
#=GS R9AV38_WALI9/759-825 AC R9AV38.1
#=GS W2ZVC1_PHYPR/392-457 AC W2ZVC1.1
#=GS U4UGJ3_DENPD/402-504 AC U4UGJ3.1
#=GS A0A024GJM2_9STRA/446-511 AC A0A024GJM2.1
#=GS A0A0D3BH17_BRAOL/132-200 AC A0A0D3BH17.1
#=GS V8NRW5_OPHHA/20-86 AC V8NRW5.1
#=GS H3BHJ6_LATCH/469-535 AC H3BHJ6.1
#=GS B4QG36_DROSI/528-593 AC B4QG36.1
#=GS C5G1C8_ARTOC/138-210 AC C5G1C8.1
#=GS K3WUK0_PYTUL/29-101 AC K3WUK0.1
#=GS A0A059BSW2_EUCGR/624-692 AC A0A059BSW2.1
#=GS A0A0A1P624_9FUNG/484-552 AC A0A0A1P624.1
#=GS A0A091WJ50_OPIHO/234-308 AC A0A091WJ50.1
#=GS A0A135UYJ3_9PEZI/155-229 AC A0A135UYJ3.1
#=GS S3CC23_OPHP1/360-457 AC S3CC23.1
#=GS A0A183SIG3_SCHSO/308-382 AC A0A183SIG3.1
#=GS T0S0S4_9STRA/267-333 AC T0S0S4.1
#=GS A0A093PPW0_9PASS/838-902 AC A0A093PPW0.1
#=GS D0P4C3_PHYIT/141-209 AC D0P4C3.1
#=GS L1IW37_GUITH/116-186 AC L1IW37.1
#=GS A0A132A792_SARSC/365-431 AC A0A132A792.1
#=GS W2Z3P2_PHYPR/610-671 AC W2Z3P2.1
#=GS I3K227_ORENI/719-784 AC I3K227.1
#=GS W6QP20_PENRF/182-305 AC W6QP20.1
#=GS Q4D2Q1_TRYCC/9-75 AC Q4D2Q1.1
#=GS J3M6Q1_ORYBR/654-722 AC J3M6Q1.1
#=GS A0A058Z247_9EUKA/25-90 AC A0A058Z247.1
#=GS E3M6Q1_CAERE/155-217 AC E3M6Q1.1
#=GS A0A067CBC9_SAPPC/467-531 AC A0A067CBC9.1
#=GS A0A091FZL1_9AVES/1095-1157 AC A0A091FZL1.1
#=GS M4BW56_HYAAE/294-372 AC M4BW56.1
#=GS V9E7J6_PHYPR/179-245 AC V9E7J6.1
#=GS A0A0L6WVH9_9AGAR/170-233 AC A0A0L6WVH9.1
#=GS V7CAY8_PHAVU/6-69 AC V7CAY8.1
#=GS V9EJP2_PHYPR/146-214 AC V9EJP2.1
#=GS G0VH05_NAUCC/228-313 AC G0VH05.1
#=GS H0X4J7_OTOGA/866-930 AC H0X4J7.1
#=GS H2TA55_TAKRU/17-83 AC H2TA55.1
#=GS B2WKU5_PYRTR/188-269 AC B2WKU5.1
#=GS U5D4V2_AMBTC/622-690 AC U5D4V2.1
#=GS A0A183BQD3_GLOPA/310-377 AC A0A183BQD3.1
#=GS W6PVV0_PENRF/370-454 AC W6PVV0.1
#=GS E9G458_DAPPU/552-616 AC E9G458.1
#=GS A0A024TUR4_9STRA/293-356 AC A0A024TUR4.1
#=GS T0QLD8_9STRA/115-178 AC T0QLD8.1
#=GS W2YBP1_PHYPR/376-440 AC W2YBP1.1
#=GS A0A091U5Q3_PHORB/1222-1287 AC A0A091U5Q3.1
#=GS K1RIB5_CRAGI/33-100 AC K1RIB5.1
#=GS A0A084G6G8_9PEZI/162-234 AC A0A084G6G8.1
#=GS H0WXA2_OTOGA/527-587 AC H0WXA2.1
#=GS EEA1_HUMAN/1347-1411 AC Q15075.2
#=GS EEA1_HUMAN/1347-1411 DR PDB; 1HYI A; 1-65;
#=GS EEA1_HUMAN/1347-1411 DR PDB; 1JOC B; 1347-1411;
#=GS EEA1_HUMAN/1347-1411 DR PDB; 1HYJ A; 1-65;
#=GS EEA1_HUMAN/1347-1411 DR PDB; 1JOC A; 1347-1411;
#=GS F7A4J2_HORSE/279-353 AC F7A4J2.1
#=GS H3BXK3_TETNG/467-526 AC H3BXK3.1
#=GS A0A0G4J3D8_PLABS/83-149 AC A0A0G4J3D8.1
#=GS M4DGT2_BRARP/613-681 AC M4DGT2.1
#=GS M4DYE9_BRARP/43-115 AC M4DYE9.1
#=GS A0A0V1PJV4_9BILA/2568-2634 AC A0A0V1PJV4.1
#=GS C1N8V0_MICPC/103-180 AC C1N8V0.1
#=GS F7HXA1_CALJA/157-220 AC F7HXA1.1
#=GS L5JZP4_PTEAL/164-230 AC L5JZP4.1
#=GS G1R7Q5_NOMLE/170-236 AC G1R7Q5.2
#=GS S7ZIY6_PENO1/502-567 AC S7ZIY6.1
#=GS K1X937_MARBU/334-417 AC K1X937.1
#=GS H2QE29_PANTR/116-179 AC H2QE29.1
#=GS Q7SEY1_NEUCR/457-522 AC Q7SEY1.1
#=GS M1CRF7_SOLTU/377-445 AC M1CRF7.1
#=GS F1Q5L9_DANRE/900-964 AC F1Q5L9.1
#=GS W2YBK8_PHYPR/108-171 AC W2YBK8.1
#=GS A0A0B0ME14_GOSAR/29-101 AC A0A0B0ME14.1
#=GS D0P252_PHYIT/176-242 AC D0P252.1
#=GS A4HEZ7_LEIBR/1153-1274 AC A4HEZ7.2
#=GS B0W4C2_CULQU/696-751 AC B0W4C2.1
#=GS F7E9C0_CALJA/206-280 AC F7E9C0.1
#=GS A0A0E0PZ18_ORYRU/229-296 AC A0A0E0PZ18.1
#=GS A0A178DV05_9PLEO/350-431 AC A0A178DV05.1
#=GS A0A0A0AMQ1_CHAVO/719-783 AC A0A0A0AMQ1.1
#=GS A0A0V0UEJ8_9BILA/1969-2032 AC A0A0V0UEJ8.1
#=GS A0A0A1MYC9_9FUNG/15-81 AC A0A0A1MYC9.1
#=GS A0A072URJ9_MEDTR/8-71 AC A0A072URJ9.1
#=GS A0A0A1N1E6_9FUNG/20-70 AC A0A0A1N1E6.1
#=GS G8ZWR7_TORDC/484-558 AC G8ZWR7.1
#=GS G1LMY2_AILME/1118-1186 AC G1LMY2.1
#=GS G3JGK7_CORMM/330-415 AC G3JGK7.1
#=GS E4ZJ06_LEPMJ/194-294 AC E4ZJ06.1
#=GS E4X398_OIKDI/160-223 AC E4X398.1
#=GS A0A101MIH2_9EURO/163-226 AC A0A101MIH2.1
#=GS K3WM22_PYTUL/268-330 AC K3WM22.1
#=GS G1NFM7_MELGA/1348-1412 AC G1NFM7.2
#=GS A0A091PHW4_LEPDC/1223-1288 AC A0A091PHW4.1
#=GS A0A0L7LG16_9NEOP/1413-1496 AC A0A0L7LG16.1
#=GS A0A0K9QAS9_SPIOL/16-78 AC A0A0K9QAS9.1
#=GS A0A0E0LNE9_ORYPU/7-70 AC A0A0E0LNE9.1
#=GS A0A066WGM5_9HOMO/390-489 AC A0A066WGM5.1
#=GS W2PNM4_PHYPN/284-349 AC W2PNM4.1
#=GS A0A067CF86_SAPPC/26-92 AC A0A067CF86.1
#=GS G3W6B0_SARHA/216-282 AC G3W6B0.1
#=GS H3GPT0_PHYRM/298-364 AC H3GPT0.1
#=GS W4HBE5_9STRA/502-568 AC W4HBE5.1
#=GS I3KMD9_ORENI/338-409 AC I3KMD9.1
#=GS G5BL44_HETGA/147-213 AC G5BL44.1
#=GS A0A158Q321_DRAME/737-804 AC A0A158Q321.1
#=GS A0A0W8BLQ4_PHYNI/68-133 AC A0A0W8BLQ4.1
#=GS G3N025_BOVIN/593-660 AC G3N025.1
#=GS Q4WYP4_ASPFU/335-419 AC Q4WYP4.1
#=GS G1NT98_MYOLU/593-659 AC G1NT98.1
#=GS F7E858_CALJA/1168-1232 AC F7E858.1
#=GS A0A078AVX8_STYLE/405-470 AC A0A078AVX8.1
#=GS A0A0W8DH59_PHYNI/361-427 AC A0A0W8DH59.1
#=GS W5LJ85_ASTMX/44-109 AC W5LJ85.1
#=GS F6TD27_HORSE/339-411 AC F6TD27.1
#=GS A0A0R3TLG8_HYMNN/3508-3574 AC A0A0R3TLG8.3
#=GS Q6EUF2_ORYSJ/218-286 AC Q6EUF2.1
#=GS A0A077Z3X9_TRITR/58-124 AC A0A077Z3X9.1
#=GS F6ZKX0_HORSE/534-598 AC F6ZKX0.1
#=GS G3QD14_GORGO/570-634 AC G3QD14.1
#=GS A0E0C6_PARTE/18-83 AC A0E0C6.1
#=GS W2PNF8_PHYPN/259-332 AC W2PNF8.1
#=GS A0A093JCU2_FULGA/147-213 AC A0A093JCU2.1
#=GS G3PF96_GASAC/1791-1858 AC G3PF96.1
#=GS E3RQL4_PYRTT/166-229 AC E3RQL4.1
#=GS W2YDI2_PHYPR/340-452 AC W2YDI2.1
#=GS H2UUQ0_TAKRU/1073-1139 AC H2UUQ0.1
#=GS W4H6L0_9STRA/372-430 AC W4H6L0.1
#=GS A0A0C3J4P0_PISTI/200-313 AC A0A0C3J4P0.1
#=GS A0A135SQ99_9PEZI/178-250 AC A0A135SQ99.1
#=GS A0A0A0M3A5_CUCSA/31-103 AC A0A0A0M3A5.1
#=GS A0A0E9NJG5_9ASCO/244-316 AC A0A0E9NJG5.1
#=GS A0A096LZ06_POEFO/92-157 AC A0A096LZ06.1
#=GS A0A0B2SGT5_GLYSO/407-473 AC A0A0B2SGT5.1
#=GS W5LRY2_ASTMX/149-214 AC W5LRY2.1
#=GS A0A183KFT6_9TREM/450-515 AC A0A183KFT6.1
#=GS A0A0L0DUN7_THETB/510-576 AC A0A0L0DUN7.1
#=GS A0A095AGY5_SCHHA/440-505 AC A0A095AGY5.1
#=GS A5DBI8_PICGU/250-341 AC A5DBI8.2
#=GS H2TWH5_TAKRU/148-264 AC H2TWH5.1
#=GS B4LKS5_DROVI/187-253 AC B4LKS5.1
#=GS H0VR83_CAVPO/147-213 AC H0VR83.1
#=GS A0A087XMT2_POEFO/331-403 AC A0A087XMT2.2
#=GS I3KS77_ORENI/695-760 AC I3KS77.1
#=GS G1NYT4_MYOLU/740-804 AC G1NYT4.1
#=GS A0A087YIS3_POEFO/1809-1874 AC A0A087YIS3.2
#=GS A0A087XY87_POEFO/1824-1890 AC A0A087XY87.2
#=GS R7VNG4_COLLI/1212-1277 AC R7VNG4.1
#=GS L5M0Z5_MYODS/1224-1286 AC L5M0Z5.1
#=GS L5MDU3_MYODS/1141-1207 AC L5MDU3.1
#=GS K3XUR4_SETIT/31-102 AC K3XUR4.1
#=GS H0YD93_HUMAN/549-613 AC H0YD93.1
#=GS G4VTD8_SCHMA/157-220 AC G4VTD8.1
#=GS A0A091MY04_9PASS/146-209 AC A0A091MY04.1
#=GS A0A096NWB3_PAPAN/813-877 AC A0A096NWB3.1
#=GS V4T3F2_9ROSI/627-695 AC V4T3F2.1
#=GS A0A061GUS0_THECC/654-722 AC A0A061GUS0.1
#=GS A0A151N553_ALLMI/131-194 AC A0A151N553.1
#=GS G4ZCS8_PHYSP/11-61 AC G4ZCS8.1
#=GS B4NIW9_DROWI/1060-1126 AC B4NIW9.2
#=GS A0A0C3HE73_9PEZI/335-416 AC A0A0C3HE73.1
#=GS A0A081CHN0_PSEA2/173-234 AC A0A081CHN0.1
#=GS A0A093JAG5_PICPB/147-213 AC A0A093JAG5.1
#=GS A0A0V0RZU3_9BILA/128-193 AC A0A0V0RZU3.1
#=GS A0A0R3QFW2_9BILA/160-212 AC A0A0R3QFW2.1
#=GS W7AIB5_PLAVN/30-96 AC W7AIB5.1
#=GS M2MS67_BAUCO/168-231 AC M2MS67.1
#=GS A0A091N4J0_9PASS/1349-1413 AC A0A091N4J0.1
#=GS A0A0H5S7P9_BRUMA/971-1035 AC A0A0H5S7P9.1
#=GS A0A0F8B598_LARCR/375-458 AC A0A0F8B598.1
#=GS L8FS27_PSED2/142-214 AC L8FS27.1
#=GS A0A162NQW7_MUCCL/140-212 AC A0A162NQW7.1
#=GS A0A091HAI6_BUCRH/679-744 AC A0A091HAI6.1
#=GS M4E4N7_BRARP/589-657 AC M4E4N7.1
#=GS I3ME90_ICTTR/2821-2887 AC I3ME90.1
#=GS B4K5Z8_DROMO/669-737 AC B4K5Z8.2
#=GS E2RRY0_CANLF/741-804 AC E2RRY0.2
#=GS X6NR80_RETFI/182-229 AC X6NR80.1
#=GS G6DB47_DANPL/131-197 AC G6DB47.1
#=GS M7YMG6_TRIUA/625-693 AC M7YMG6.1
#=GS T0QLL1_9STRA/123-187 AC T0QLL1.1
#=GS A0A183JH71_9TREM/39-113 AC A0A183JH71.1
#=GS K3X630_PYTUL/1346-1410 AC K3X630.1
#=GS H3AHZ4_LATCH/193-258 AC H3AHZ4.1
#=GS C3YPL0_BRAFL/153-265 AC C3YPL0.1
#=GS A0A093J411_FULGA/715-758 AC A0A093J411.1
#=GS W2YP21_PHYPR/318-397 AC W2YP21.1
#=GS I3K3H3_ORENI/41-107 AC I3K3H3.1
#=GS A0A0J8QTQ6_COCIT/334-418 AC A0A0J8QTQ6.1
#=GS B4I8L8_DROSE/621-686 AC B4I8L8.1
#=GS A0A151XF79_9HYME/498-563 AC A0A151XF79.1
#=GS G3VL22_SARHA/1102-1164 AC G3VL22.1
#=GS A0A0G2K2S8_RAT/554-618 AC A0A0G2K2S8.1
#=GS M0XDD8_HORVD/436-518 AC M0XDD8.1
#=GS A0A024WHR7_PLAFA/31-97 AC A0A024WHR7.1
#=GS Q23VE6_TETTS/45-109 AC Q23VE6.3
#=GS M7CEU6_CHEMY/147-213 AC M7CEU6.1
#=GS A0A0P1ARW5_9STRA/187-251 AC A0A0P1ARW5.1
#=GS W2QXJ1_PHYPN/25-93 AC W2QXJ1.1
#=GS W4G0I3_9STRA/24-89 AC W4G0I3.1
#=GS A0A0V0U1Y5_9BILA/128-193 AC A0A0V0U1Y5.1
#=GS H2UMZ0_TAKRU/603-670 AC H2UMZ0.1
#=GS W6L408_9TRYP/179-348 AC W6L408.1
#=GS W6UHZ9_ECHGR/162-287 AC W6UHZ9.1
#=GS A0A0N7L459_9STRA/284-349 AC A0A0N7L459.1
#=GS A0A0S7DED8_9EURO/490-555 AC A0A0S7DED8.1
#=GS F1MD79_BOVIN/1112-1174 AC F1MD79.2
#=GS HRS_DROME/156-219 AC Q960X8.1
#=GS HRS_DROME/156-219 DR PDB; 1DVP A; 156-219;
#=GS A0A091SAC8_NESNO/186-260 AC A0A091SAC8.1
#=GS H2WD53_CAEJA/793-862 AC H2WD53.2
#=GS A0A091WJH5_NIPNI/147-213 AC A0A091WJH5.1
#=GS W5LDG8_ASTMX/157-220 AC W5LDG8.1
#=GS B6JXN3_SCHJY/14-105 AC B6JXN3.1
#=GS M4DSL8_BRARP/644-710 AC M4DSL8.1
#=GS A0A0N4XF34_NIPBR/3-59 AC A0A0N4XF34.1
#=GS A0A078C1J0_BRANA/37-112 AC A0A078C1J0.1
#=GS A0A093PR42_9PASS/352-417 AC A0A093PR42.1
#=GS A0A091S5R6_NESNO/1218-1283 AC A0A091S5R6.1
#=GS A0A091SCU6_NESNO/1339-1403 AC A0A091SCU6.1
#=GS A0A178AI31_9PLEO/166-229 AC A0A178AI31.1
#=GS A0A058Z8D6_9EUKA/985-1050 AC A0A058Z8D6.1
#=GS A0A0N4Y5G6_NIPBR/716-782 AC A0A0N4Y5G6.2
#=GS D0NNV9_PHYIT/427-491 AC D0NNV9.1
#=GS A0A0D3EZ20_9ORYZ/420-488 AC A0A0D3EZ20.1
#=GS A0A0D2WI88_CAPO3/475-541 AC A0A0D2WI88.1
#=GS M7NSE3_PNEMU/2477-2536 AC M7NSE3.1
#=GS Q8IEL2_PLAF7/50-120 AC Q8IEL2.1
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