GenomeNet

Database: Pfam
Entry: FimH_man-bind
LinkDB: FimH_man-bind
Original site: FimH_man-bind 
#=GF ID   FimH_man-bind
#=GF AC   PF09160.8
#=GF DE   FimH, mannose binding
#=GF AU   Sammut SJ
#=GF SE   pdb_1klf
#=GF GA   25.00 25.00;
#=GF TC   26.10 25.20;
#=GF NC   23.20 21.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   12010488
#=GF RT   Structural basis of tropism of Escherichia coli to the bladder
#=GF RT   during urinary tract infection. 
#=GF RA   Hung CS, Bouckaert J, Hung D, Pinkner J, Widberg C, DeFusco A,
#=GF RA   Auguste CG, Strouse R, Langermann S, Waksman G, Hultgren SJ; 
#=GF RL   Mol Microbiol. 2002;44:903-915.
#=GF DR   INTERPRO; IPR015243;
#=GF DR   SCOP; 1klf; fa;
#=GF CC   Members of this family adopt a secondary structure consisting of
#=GF CC   a beta sandwich, with nine strands arranged in two sheets in a
#=GF CC   Greek key topology. They are predominantly found in bacterial
#=GF CC   mannose-specific adhesins, since they are capable of binding to
#=GF CC   D-mannose [1].
#=GF SQ   26
#=GS I0DVK2_PROSM/41-190      AC I0DVK2.1
#=GS K8WEF5_9ENTR/1-95        AC K8WEF5.1
#=GS W0LFI5_9ENTR/30-173      AC W0LFI5.1
#=GS A8AMS7_CITK8/25-168      AC A8AMS7.1
#=GS D2TJL9_CITRI/25-170      AC D2TJL9.1
#=GS C3K852_PSEFS/25-182      AC C3K852.1
#=GS FIMH_ECOLI/24-168        AC P08191.2
#=GS FIMH_ECOLI/24-168        DR PDB; 3ZL1 B; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4X50 B; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1KIU L; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 3RFZ D; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4AVK B; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4XO8 B; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4AUY A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4AVJ A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 3RFZ A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4J3O H; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4AVJ B; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1KIU D; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1UWF A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1QUN D; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4CSS A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4XOB G; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1QUN J; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4AVK A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1KLF H; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1KLF N; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4AUY B; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4XOB A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1KLF D; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1KLF P; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4ATT A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4XOA G; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4X50 A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1QUN L; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4AV5 D; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4AVI B; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4AV5 B; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4AUU B; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4AV4 A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4AUJ A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 3ZL2 A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4AVH A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4XO8 A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4AVI A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1TR7 A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1QUN B; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4AUU A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 2VCO A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1QUN H; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4XOB C; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4X5R C; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4CST A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4AVH B; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1KLF J; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4XOA A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4AV0 A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4XOA E; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4AV5 C; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1TR7 B; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4XO9 A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1KLF L; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1QUN F; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1KIU J; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4X5Q A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 3ZL1 A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1QUN P; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1KLF B; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1KIU H; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 2VCO B; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1KIU N; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4XOA C; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4XOB E; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4AV5 A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1KIU F; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1KIU P; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1QUN N; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4X5P A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4X5R A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1KLF F; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4AV0 B; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4LOV A; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 1KIU B; 3-147;
#=GS FIMH_ECOLI/24-168        DR PDB; 4X5R B; 3-147;
#=GS A0A089PQ89_PLUGE/24-170  AC A0A089PQ89.1
#=GS A0A0A2VY98_BEABA/20-162  AC A0A0A2VY98.1
#=GS YDEQ_ECOLI/27-171        AC P77588.1
#=GS A0A068Z4M1_9ENTR/36-185  AC A0A068Z4M1.1
#=GS K8W5I6_9ENTR/1-98        AC K8W5I6.1
#=GS B2VGL4_ERWT9/32-181      AC B2VGL4.1
#=GS W0L8D6_9ENTR/29-179      AC W0L8D6.1
#=GS I6F9J0_SHIFL/24-168      AC I6F9J0.1
#=GS B2VEY7_ERWT9/28-172      AC B2VEY7.1
#=GS A0A068Z4I0_9ENTR/36-185  AC A0A068Z4I0.1
#=GS D4C224_PRORE/29-183      AC D4C224.1
#=GS B4F2K7_PROMH/28-177      AC B4F2K7.1
#=GS K8WLZ7_9ENTR/22-176      AC K8WLZ7.1
#=GS A6TDM0_KLEP7/25-169      AC A6TDM0.1
#=GS Q32FX7_SHIDS/2-92        AC Q32FX7.1
#=GS L0MB12_SERMA/25-174      AC L0MB12.1
#=GS K8WKU3_PRORE/22-176      AC K8WKU3.1
#=GS B4ETK5_PROMH/25-171      AC B4ETK5.1
#=GS A0A089UIZ7_9ENTR/25-167  AC A0A089UIZ7.1
I0DVK2_PROSM/41-190                 ........ds--TGNVLDSlSG.TAT...ANV.Y.VNLQPSVQAGQNLV...VD...LSRSIFCRND..SPLTR....RDLVSMRR..GSAY..GGVLSN...FNG...SLRYYTSSYPFPLVSP.THQQNF...PSGNYTPWNTQLYLTPI..SAAGGVVINKGTRFATLVMYQVGSalVGGGN..vET..aTFTWN........
K8WEF5_9ENTR/1-95                   .........m---------.--.---...---.-.--------------...--...----------..-----....------LS..GSAY..SGVLAN...FRG...SLRYYGSSYPFPLTSP.THQHSF...PSGNYTPWNTQLYLTPI..SSAGGVVLNKGARFATLVMYQVGSdiIGGGN..vHT..vTFTW-h.......
W0LFI5_9ENTR/30-173                 ..........CQTAAGATIpIG.GGN...ADV.Y.VTLSPQIGVGQNLI...VD...LSTQISCRND..FPQTI....KDFVSLQA..GSAY..GGVLAN...FRG...SFVYGGISYPFPTTNE.THSIEF...KTTTMTPWPAVLYLTPI..SSAGGVAITSGSLIAMLNMHQTND..KGESH...P-...-YIWR........
A8AMS7_CITK8/25-168                 ..........CKVNDTGQT.MT.SGS...ANV.Y.VNLTPSVGVGQNLV...VD...LSSSVSCKND.sSGGSI....IDYINLTS..GSAF..GGALAA...FTG...SVYWAGNTYPLPMNGN.SSVYTI...THTDYLGLPLRMYLTAT..GAAGGVVINSGELIAQLNMHKVAS..--DGN...PN...NFIWN........
D2TJL9_CITRI/25-170                 ........ct---TTGGDIgIG.GGD...AHI.Y.VDLTPQVNVGQNLL...ID...LSTQIFCHND..YPDSM....TDFVTLTV..QSVY..DGVLKS...FTG...TLRYDGTTYPFPLQNE.TREIRY...TSKKPTPWPVALYLTPV..STAGGVVISAGTQIATLDLRQTNN..VNSDN...FT...-----fkfyih..
C3K852_PSEFS/25-182                 ..........CRVNGGPWIfVGaGGT...LNL.Q.VPVTVQLGADRTRI...ML...EGVRLECRFS.gFGGSQp.wyTDYWATSArvGPAWvpGPKFAN...QGT...GLRINGSYYNNPVPNG.IRMTTM..pNNLIGVPVDVTPYILVR.nDPANPIDVRIGDVLGRLNLDQTNN..YNSGS...S-...-----alavtyt.
FIMH_ECOLI/24-168                   ..........CKTANGTAIpIG.GGS...ANV.Y.VNLAPVVNVGQNLV...VD...LSTQIFCHND..YPETI....TDYVTLQR..GSAY..GGVLSN...FSG...TVKYSGSSYPFPTTSE.TPRVVY...NSRTDKPWPVALYLTPV..SSAGGVAIKAGSLIAVLILRQTNN..YNSDD...F-...QFVWN........
#=GR FIMH_ECOLI/24-168        SS    ..........EEETTSEEE-TT.SEE...EEE.E.E---SBEETTSEEE...EE...GGGTEEEE-S..STTT-....-EEEEEEE..EEEE..HHHHHH...EEE...EEEETTEEEEES-SS-.---EEE...-SSS-EE--EEEEEEES..TTSSEEEE-TTSEEEEEEEEEEES..SSS-E...E-...EEEEE........
A0A089PQ89_PLUGE/24-170             ..........CKILSTGQM.VQ.TGS...ANL.Y.VNLTPQIGIGQNLI...VD...LTQEIKCKNDsaPPDID....VDHLKLLS..GSAY..QGALDN...FSG...AVYWVGKYYPIPLTAN.TPYYSI...SNTSYAPLPLKLYLTPL..GAAGGKLIRSGELIAVLSVYKIAT..FDGGY...PT...TFTWN........
A0A0A2VY98_BEABA/20-162             ......cqsl-----GTTI.SG.SGT...VTV.R.VNLVPSISAGQNLV...VD...LSQSIQCKND..APSVY....LDPVRIRS..GSAY..QGVLSA...FRG...TLGYFGVQYPFPTTTE.TAWVNH...TWGDYRGWQAVLYLTPI..STASGVVVKANTMIAQLILEKEDS..LNGNR...Q-...IINWN........
YDEQ_ECOLI/27-171                   ..........CNVDGGS-S.IG.AGT...TSV.Y.VNLDPVIQPGQNLV...VD...LSQHISCWND..YGGWY...dTDHINLVQ..GSAF..AGSLQS...YKG...SLYWNNVTYPFPLTTN.TNVLDI...GDKTPMPLPLKLYITPV..GAAGGVVIKAGEVIARIHMYKIAT..LGSGN...PR...NFTWN........
A0A068Z4M1_9ENTR/36-185             ..........CHNKQTGKT.II.EGD...SSV.T.VPISRTVTPGEQVV...ID...VGKYYECKNT..DPREY....SDYMDTQD..NASS..TNLPPE...FET...GAYINGGKYSFPL-PK.VNVLTLpkgGDSNYHIVPIQVFYTMK.eDPGQMVKISKGETLAILKLHKYAT..TTGGP..rDL..hDFTWN........
K8W5I6_9ENTR/1-98                   .........m---------.--.---...---.-.--------------...--...----------..-----....---VNMVN..GSAF..SGLLAK...FNG...SIRYYGASYPFPLNSP.THQKSF...PLGNYTAWSAQIYLTPI..STAGGVVINKGTHFATLVMYQAGTniNGGGD..mST..aTFTWK........
B2VGL4_ERWT9/32-181                 ..........CRNKQTGQS.LK.GGN...SSV.T.VPISRTLTFGEQVV...FD...IGQYYECKND..NPGTY....SDYMETQA..NASS..TTLPTA...FDT...GALINGGKYDFPL-PQ.VNVFTLpkgGDSNYHNVPIQVYYSMK.dTPGQLVKISKGQTLATLQLHKYAT..TTGGP..qDP..qDFTWN........
W0L8D6_9ENTR/29-179                 ........ds--TGNTLNSaSG.TAT...ATV.Y.VNLQPSITASQNLV...VD...LSNSIFCKND..NPTVR....NDHVSLLN..GSAY..GGVLSN...FNG...TVEYYGSSYPFPLRSA.TSSKNF...TSGTYTKWDAKLYLTPL.sSAASGVVVKKNSQFASLVMFQRGSniVGGGN..vHT..aTFTWN........
I6F9J0_SHIFL/24-168                 ..........CKTANGTAIpIG.GGS...ANV.Y.VNLAPVVNVGQNLV...VD...LSTQIFCHND..YPETI....TDYVTLQR..GSAY..GGVLSN...FSG...TVKYSGSSYPFPTTSE.TPRVVY...NSRTDKPWPVALYLTPV..SSAGGVAIKAGSLIAVLILRQTNN..YNSDD...F-...QFVWN........
B2VEY7_ERWT9/28-172                 ..........CRTAGGVEIpIG.GGS...ANV.Y.VNLTPSVGIGQNLV...VD...LATQIACRND..YPSTH....TDYVSLLQ..GSAY..GGALKN...FKG...SIIYSDSTYPFPTTSE.TKILTY...KSKTETPWPTKLYLTAI.gSAADGVAIKAGTLVAILNMHQTNN..YNESN...S-...-YVWN........
A0A068Z4I0_9ENTR/36-185             ..........CHNKQTGKI.LK.GGD...SSV.T.VPISRTVTPGEQVI...ID...IGKYYECKND..LPRYY....NDYMYTQD..NASS..TTLPPE...FET...GAYINGGKYSFPL-PE.VNVLTLpkgGDGNYHIVPIQVFYTMK.eDPGKMVKISKGETLAILKLHKYAT..TTGGPi.dPQ...YFTWN........
D4C224_PRORE/29-183                 ..........CKTNGGQE-.VG.GGT...QSI.YdVPLDNDIFAVPNRInefAD...VSDFMTCRNE..APSAY....VDYLNVT-..GADL..GPTFKNnpeLKA...GVVVRGAYYLAPFSGKeIQVFRL...-TTASEPLQIKLYLQVN.vKPTPSVLVRKGDLLMTLDLHKYAT..FVNSNqhiDH..aYFKWN........
B4F2K7_PROMH/28-177                 ..........CKVASTGQI.VG.DGA...ANI.R.VNLTPRVEVNQNLV...VD...LSQQILCKND.sYGGPRdpidVDHVNLVS..GTTF..GGALNN...FDG...SLLWYNSYYPIPLYYD.TKVINI...KDRNFIPLNLRLYLKSI..GAAGGKQINKGDLIAKIEMYKIAD..WDGGH...PR...FFTWN........
K8WLZ7_9ENTR/22-176                 ..........CKTNAGQE-.VS.SGT...QSInN.IPIDNDIFAVPNRI...NEfanVNDYMTCRNE..LPSAY....VDYLNLQS..M-TL..GPVLQSnpdLKA...GVSVRGVRYLAPFSGR.DIQIFR...LTQSSESLQIKLYIQVN.hKPTPSVLIKKGDLLMTLGLQKYAT.rVRSNN...PIdflNFTW-k.......
A6TDM0_KLEP7/25-169                 ..........CKTATGATIpIG.GGS...ANV.Y.VNLTPAVNVGQNLV...VD...LSTQIFCHND..YPETI....TDYVTLQR..GSAY..GGVLSS...FSG...TVKYNGTSYPFPTTTE.TARVIY...DSRTDKPWPAVLYLTPV..STAGGVAITAGSLIAVLILHQTNN..YNSDS...F-...QFIWN........
Q32FX7_SHIDS/2-92                   kntcstnwkh---------.--.---...---.-.--------------...--...----------..-----....--------..----..---HQS...YKG...SLYWNNVTYPFPLTTN.TNVLDI...GDKTPMPLPLKLYITPV..GAAGGVVIKAGEVIARIHMYKIAT..LGSGN...PR...NFTWN........
L0MB12_SERMA/25-174                 ..........CQTSDGDHI.PP.GGSiapVDV.R.VRIGPQLSYGKNEI...VN...VSQ-VTCKND..TASWI....-DYLNTDI..-SAL..TMNNAI...FGGigsGTTINGTDYNSPVPAG.ISVMTL...TNLNQQTVNIRVYIVLS.hFPTPDIKINKGDVIGQINFRQTND..RPACP...--...-----kcgpyhwr
K8WKU3_PRORE/22-176                 ..........CKTNGGQE-.VG.GGT...QSI.YdVPLDNDIFAVPNRInefAD...VSDFMTCRNE..APSAY....VDYLNVT-..GADL..GPTFKNnpeLKA...GVVVRGAYYLAPFSGKeIQVFRL...-TTASEPLQIKLYLQVN.vKPTPSVLVRKGDLLMTLDLHKYAT..FVNSNqhiDH..aYFKWN........
B4ETK5_PROMH/25-171                 ..........CSVDNGYD-.IE.SGN...YNI.Y.VQLEAEVQPYQNLI...VD...LSRHLKCWNS..YGGWQ...dVDHINLEP..GTGL..SGPLFN...FSG...SVYWYGNTYSLPLNSA.TKVLHI...GDLTPMPMPMMLYLTPInnSPAGGVLIRSGETIATINMYKIAD..WDGGN...PK...YFTW-e.......
A0A089UIZ7_9ENTR/25-167             ......cqsl-----GTSI.SG.SGT...VNV.K.VNLVPSISAGQNLV...VD...LSQSIQCKND..APAQY....TDPVRIKS..GSAY..QGVLSA...FRG...SLGYYGVQYPFPTTTE.TAWVNH...TWGDYRGWQAVLYLTPI..STASGVVVKANTMIAQLILEKEDS..INGNR...Q-...IINWN........
#=GC SS_cons                        ..........EEETTSEEE-TT.SEE...EEE.E.E---SBEETTSEEE...EE...GGGTEEEE-S..STTT-....-EEEEEEE..EEEE..HHHHHH...EEE...EEEETTEEEEES-SS-.---EEE...-SSS-EE--EEEEEEES..TTSSEEEE-TTSEEEEEEEEEEES..SSS-E...E-...EEEEE........
#=GC seq_cons                       ..........Cpsssssp..lu.uGo...ssl.h.VsLssslssGpNll...lD...lSppltC+ND..hPssh....sDalslps..GSAa..uGsLss...FpG...olhatGspYPFPhssp.Tphhsh...ssps.pPhslpLYLTsl..usAuGVsIppGshlApLphaphuo..hsuus...s.....FsWN........
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