GenomeNet

Database: Pfam
Entry: Flu_PB1
LinkDB: Flu_PB1
Original site: Flu_PB1 
#=GF ID   Flu_PB1
#=GF AC   PF00602.15
#=GF DE   Influenza RNA-dependent RNA polymerase subunit PB1
#=GF AU   Bateman A
#=GF SE   Bateman A
#=GF GA   25.10 25.10;
#=GF TC   143.20 141.60;
#=GF NC   20.70 20.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   9348094
#=GF RT   Identification of two nucleotide-binding domains on the PB1
#=GF RT   subunit of influenza virus RNA polymerase. 
#=GF RA   Asano Y, Ishihama A; 
#=GF RL   J Biochem (Tokyo) 1997;122:627-634.
#=GF RN   [2]
#=GF RM   8948635
#=GF RT   Identification of two separate domains in the influenza virus
#=GF RT   PB1 protein involved in the interaction with the PB2 and PA
#=GF RT   subunits: a model for the viral RNA polymerase structure. 
#=GF RA   Gonzalez S, Zurcher T, Ortin J; 
#=GF RL   Nucleic Acids Res 1996;24:4456-4463.
#=GF DR   INTERPRO; IPR001407;
#=GF CC   Two GTP binding sites exist in this protein [1].
#=GF SQ   6
#=GS RDRP_THOGV/3-705   AC O41353.1
#=GS RDRP_I34A1/1-742   AC P03431.2
#=GS RDRP_I34A1/1-742   DR PDB; 2ZTT A; 685-742;
#=GS RDRP_I34A1/1-742   DR PDB; 3A1G C; 685-742;
#=GS RDRP_I34A1/1-742   DR PDB; 2ZNL B; 1-15;
#=GS RDRP_I34A1/1-742   DR PDB; 2ZTT C; 684-742;
#=GS RDRP_I34A1/1-742   DR PDB; 3A1G A; 685-742;
#=GS RDRP_INCAA/1-738   AC Q6I7C3.1
#=GS RDRP_ISAV8/14-568  AC Q8V3T6.1
#=GS RDRP_INBLE/1-741   AC P07832.1
#=GS RDRP_I96A0/1-742   AC Q9Q0V0.1
#=GS RDRP_I96A0/1-742   DR PDB; 3J9B B; 1-24;
#=GS RDRP_I96A0/1-742   DR PDB; 3J9B I; 1-24;
RDRP_THOGV/3-705              lftprseinp------------------TTTqellYAYTGPAPVAYGTRTRAVLENIIRPYQyfYKE.PNVQRALDIK-------TGCKEPEDiNVEGPSSGFHTASVLKLADNFFRKYRPAM-EKLKYWILVKLPKLKYAELSKGRQTYSFIHKRNLPAPIALEETVEFLEQN.LRRKIGPTLLSYCQAIADVMELDETTYEGARdprpwDIQLEEIDSDEEDPLFRQVGREETYTIKfsREELWDQMRTLNTMCKHLERGRLNRRTIATPSMLIRGFVKIVEDAAKEILENV.PTSGVPVGGEEKLAKLAS------KQTFHTAVTGELSGDQEKFNECLDPDAMRLMWTVFLRKlgCPDWIMELFNIPFMVFKSKLADMGEGLVYTKGKLTDRKplgEMPSE.....----FDDLVRNV.VGN-.---...----SISCRLGMFMGMYNLTSTLLALISI..EREELTGSH-----VESSDDFIHFFNCKTHEEMFKQAETLRLTLKLVGINMSPSKCiLISPAGIGEFNSKFHHRDFVGNVATELPALV.PNGTNPMTDLAMGLNVIKHSVNTGQMNLCTGALAMRIFNHAYKYAYM-----ALGVTRRTRFMEE-----NAITPLLTNQGASPVHSFSTMHLDEVALRrhLGLLDEETLRRILNPNNPVTQKG.....DPSMFFRIENKMpQIMEDYSVPSCFKYTLSRNRTIQDKPHKALLNKEERYQRVTSIINKLFPEVLIQEASAPGTVRESLKRRLElvvERSDLDEE-----------rkkri...............
RDRP_I34A1/1-742              ..........MDVNPTLLFLKVPAQNAISTT....FPYTGDPPYSHGTGTGYTMDTVNRTHQ..YSE.KGRWTTNTETGAPQLNPIDGPLPED.--NEPSGYAQTDCVLEAMAFLEESH-PGIFENSCIETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNgLTANESGRLIDFLKDVMESMKKEEMGITTHF.....QRKRRVRDNMTKKMITQRTIGKKKQRLN..KRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKL.EQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYMTRN..QPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRT...QIPAEmlasiDLKYFNDSTRKK.IEKI.RPL...LIEGTASLSPGMMMGMFNMLSTVLGVSILnlGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLLGINMSKKKS.YINRTGTFEFTSFFYRYGFVANFSMELPSFG.VSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFEIKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLK..WELMDEDYQGRLCNPLNPFVSHKeiesmNNAVMMPAHGPA.KNMEYDAVATTHSWIPKRNRSILNTSQRGVLEDEQMYQRCCNLFEKFFPSSSYRRPVGISSMVEAMVSRAR...IDARIDFESGRIKKEEFT-e...................
#=GR RDRP_I34A1/1-742   SS    ..........XEEXGGGGGGTSXXXXXXXXX....XXXXXXXXXXXXXXXXXXXXXXXXXXX..XXX.XXXXXXXXXXXXXXXXXXXXXXXXX.--XXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXXXXXXXXXXXXXXXX.XXXX.XXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-HHHHHHHHHHHHHHS-TT-SS---TTSBHHHHHHHHHH...HHHHHHHHTTSS-HHHHH-H...................
RDRP_INCAA/1-738              ..........MEINPYLMFLNNDVTSLISTT....YPYTGPPPMSHGSSTKYTLETIKRTYD..YSR.TSVEKTSKVFNIPRRKFCNCLEDKD.ELVKPTGNVDISSLLGLAEMMEKRMGEGFFKHCVMEAETEILKMHFSRLTEGRQTYDWTSERNMPAATALQLTVDAIKET.EGPFKGTTMLEYCNKMIEMLDWKEVKFRKVK.....TMVRREKDKRSGKEIKTKVPVMGIDSIK..HDEFLIRALTINTMAKDGERGKLQRRAIATPGMIVRPFSKIVETVAQKICEKL.KESGLPVGGNEKKAKLKTTVTSLNARMNSDQFAVNITGDNSKWNECQQPEAYLALLAYITKD..SSDLMKDLCSVAPVLFCNKFVKLGQGIRLSNKRKTKEV...IIKAE.....KMGKYKNLMREE.YKNLfEPLekyIQKDVCFLPGGMLMGMFNMLSTVLGVSTLcyMDEELKAKGCFWTGLQSSDDFVLFAVASNWSNIHWTIRRFNAVCKLIGINMSLEKS.YGSLPELFEFTSMFFDGEFVSNLAMELPAFT.TAGVNEGVDFTAAMSIIKTNMINNSLSPSTALMALRICLQEFRATYRVHPWDSRVKGGRMKIINEFIKTIENKDGLLIADGGKLMNNISTLHIPEEVLK..FEKMDEQYRNRVFNPKNPFTNFD.....KTIDIFRAHGPI.RVEENEAVVSTHSFRTRANRTLLNTDMRAMMAEEKRYQMVCDMFKSVFESADINPPIGAMSIGEAIEEKLL...ERAKMKRDIGAIEDSEYEE....................
RDRP_ISAV8/14-568             .....slism--------------SNDVSCL....YVYDGPMRVFSQNALMPTLQSVKRSDQ..FSKgKTKRFIIDLFGMKRMWDIGNKQLEDeNLDETVGVADLGLVKYLINNKYDEAEKTSLRKSMEEAFEKSMNEEFVVLNKGKSANDIISDTNAMCKFCVKNWIVA----.-TGFRGRTMSDLIEHHFRCM-------QGKQ.....EVKGYIWKHKYNERLKRKQLSKEEVKFD..REEYTSRSFRLLSFLKNSERTKLEPRAVFTAGVPWRAFIFVLEQTM-LVVNKLdPNSVIWMGSDAKINTTNSRIKEIG-MKNQGQTLVTLTGDNSKYNESMCPEVMMVFLRELGIK..GP--MLEVLDYALWQFSQKSVKPVA--PIKKRTGKSTV...VIKAD.....SVKECRDAFNEKeLELI.QGVe.wMDDGFVRVRRGMLMGMANNAFTTAS--TI.aSSFSFTPEA--VYTLQSSDDFVTGSCGRDVQHARQRLEMALKVSKAAGLNVSQKKS.FYVEGTTFEFNSMFVRDGKVMANGGNFENMTvPGGLGPSTDLFVVGKQARNSMLRGNLSFSQAMEMCKIGITNVEKVYYGNR-------------------------------------------------..-----------------------.....------------.-----------------------------------------------------------------------...-------------------kyqelkneirekcgeetmsi
RDRP_INBLE/1-741              ..........MNINPYFLFIDVPIQAAISTT....FPYTGVPPYSHGTGTGYTIDTVIRTHE..YSN.KGKQYISDVTGCVMVDPTNGPLPED.--NEPSAYAQLDCVLEALDRMDEEH-PGLFQAGSQNAMEALMVTTVDKLTQGRQTFDWTVCRNQPAATALNTTITSFRLNdLNGADKGGLVPFCQDIIDSLDKPEMIFFTVK.....NIKKKLPAKNRKGFLIKRIPMKVKDRIT..RVEYIKRALSLNTMTKDAERGKLKRRAIATAGIQIRGFVLVVENLAKNICENL.EQSGLPVGGNEKKAKLSNAVAKMLSNCPPGGISMTVTGDNTKWNECLNPRIFLAMTERITRD..SPIWFRDFCSIAPVLFSNKIARLGKGFMITSKTKRLKA...QIPCPdlfniPLERYNEETRAK.LKKL.KPF..fNEEGTASLSPGMMMGMFNMLSTVLGVAAL..GIKNIGNKEYLWDGLQSSDDFALFVNAKDEETCMEGINDFYRTCKLLGINMSKKKS.YCNETGMFEFTSMFYRDGFVSNFAMELPSFG.VAGVNESADMAIGMTIIKNNMINNGMGPATAQTAIQLFIADYRYTYKCHRGDSKVEGKRMKIIKELWENTKGRDGLLVADGGPNLYNLRNLHIPEIILK..YNIMDPEYKGRLLHPQNPFVGHLsiegiKEADITPAHGPI.KKMDYDAVSGTHSWRTKRNRSILNTDQRNMILEEQCYAKCCNLFEACFNSASYRKPVGQHSMLEAMAHRLR...MDARLDYESGRMSKEDFEK....................
RDRP_I96A0/1-742              ..........MDVNPTLLFLKVPAQNAISTT....FPYTGDPPYSHGTGTGYTMDTVNRTHQ..YSE.KGKWTTNTETGAPQLNPIDGPLPED.--NEPSGYAQTDCVLEAMAFLEESH-PGIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLKRNQPAATALANTIEVFRSNgLTANESGRLIDFLKDVMESMDKGEMEIITHF.....QRKRRVRDNMTKKMVTQRTIGKKKQRLN..KRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKL.EQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITRN..QPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRT...QIPAEmlasiDLKYFNESTRKK.IEKI.RPL...LIDGTASLSPGMMMGMFNMLSTVLGVSILnlGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIEAGVDRFYRTCKLVGINMTKKKS.YINRTGTCEFTSFFYRYGFVANFSMELPSFG.VSGINESADMSIGVTVIKNNMMDNDLGPATAQMALQLFIKDYRYPYRCHRGDTQIQTRRSFELKKLWEQTRSKAGLLVSDGGPNPYNIRNLHIPEAGLK..WELMDEDYQGRLCNPLNPFVSHKeiesvNNAVVMPAHGPA.KSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRAR...IDARIDFESGRIKKEEFA-e...................
#=GR RDRP_I96A0/1-742   SS    ..........----TTHHHHHS-HHHHGGGG....S--XXXXXXXXXXXXXXXXXXXXXXXX..XXX.XXXXXXXXXXXXXXXXXXXXXXXXX.--XXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXXXXXXXXXXXXXXXX.XXXX.XXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXXXXXXXXXXXX-X...................
#=GC SS_cons                  ..........-EE-CCHHHHCS-HHHHGGGG....S--XXXXXXXXXXXXXXXXXXXXXXXX..XXX.XXXXXXXXXXXXXXXXXXXXXXXXX.--XXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXXXXXXXXXXXXXXXX.XXXX.XXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXHHHHHHHHHHHHHHSXTTXSSXXXTTSBHHHHHHHHHH...HHHHHHHHTTSSXHHHHH-H...................
#=GC seq_cons                 ..........MplNPhhhFlpsshpssISTT....aPYTGsPPhSHGTuTtYTl-TVpRTaQ..YSc.Ku+ppssclpGhsphpshss..PED...sEPSGhAphssVLchhshh--ca.PGhFcpushEshEtl.pp+hs+LTpGRQTYDWThcRNtPAATALpsTI-sh+pN.LsutcussLl-ahpclh-sM-htEhthpstp.....phK++lhDpppcchlpp+shsKccp+ls..+cEYlhRALTLNTMsKDuERGKLcRRAIATPGM.IRGFVhlVEslA+pICEKL.cpSGLPVGGNEKKAKLussVpchhspspssplohTlTGDNoKWNEs.sPchaLAMlshlTRc..sP-Wh+-lhSIAPlhFSNKhA+LGcGhhhpsKoh+h+s...pIPAE.....slchas-tsRcK.lcpl.cPl...h.-GosSLssGMhMGMFNMLSTVLGVusL.hupcchTspshhWsGLQSSDDFsLhsNApsaEshptsl-cFh+TCKLlGINMSpKKS.YhscsGhFEFTShFaRtGFVuNhuMELPuFs.suGlNESsDhulGholIKNNMlsNsLuPuTAthAlplFIp-YRYsY+sHRhDoplps+R.h.lcchhcphcu+sGLLluDGGsshaNlpsLHIPEhsLK..aplMDE-YpsRlhNP.NPFss+t.....psushh.AHGPh.+.ME.-AVsoTHSahs+RNRoILNTspRuhlt-EphYQ+sCslFcphFsSushpcPlG.tShhEAhhpRhc....cA+lDhE.Gthpcp-at.c...................
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