GenomeNet

Database: Pfam
Entry: Fve
LinkDB: Fve
Original site: Fve 
#=GF ID   Fve
#=GF AC   PF09259.7
#=GF DE   Fungal immunomodulatory protein Fve
#=GF AU   Sammut SJ
#=GF SE   pdb_1osy
#=GF GA   25.00 25.00;
#=GF TC   28.00 25.20;
#=GF NC   24.50 23.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   12948495
#=GF RT   A 1.7A structure of Fve, a member of the new fungal
#=GF RT   immunomodulatory protein family. 
#=GF RA   Paaventhan P, Joseph JS, Seow SV, Vaday S, Robinson H, Chua KY,
#=GF RA   Kolatkar PR; 
#=GF RL   J Mol Biol. 2003;332:461-470.
#=GF DR   INTERPRO; IPR015339;
#=GF DR   SCOP; 1osy; fa;
#=GF CC   Fve is a major fruiting body protein from Flammulina velutipes,
#=GF CC   a mushroom possessing immunomodulatory activity. It stimulates
#=GF CC   lymphocyte mitogenesis, suppresses systemic anaphylaxis
#=GF CC   reactions and oedema, enhances transcription of IL-2, IFN-gamma
#=GF CC   and TNF-alpha, and haemagglutinates red blood cells. It appears
#=GF CC   to be a lectin with specificity for complex cell-surface
#=GF CC   carbohydrates. Fve adopts a tertiary structure consisting of an
#=GF CC   immunoglobulin-like beta-sandwich, with seven strands arranged
#=GF CC   in two beta sheets, in a Greek-key topology. It forms a
#=GF CC   non-covalently linked homodimer containing no Cys, His or Met
#=GF CC   residues; dimerisation occurs by 3-D domain swapping of the
#=GF CC   N-terminal helices and is stabilised predominantly by
#=GF CC   hydrophobic interactions [1].
#=GF SQ   20
#=GS N1LNI9_9BACI/768-862  AC N1LNI9.1
#=GS N1LHK0_9BACI/767-857  AC N1LHK0.1
#=GS C7ZE17_NECH7/5-113    AC C7ZE17.1
#=GS R8XTM4_BACCE/770-885  AC R8XTM4.1
#=GS M2R9U0_CERS8/4-78     AC M2R9U0.1
#=GS G5CJT8_9APHY/4-112    AC G5CJT8.1
#=GS K5W7W1_PHACS/41-71    AC K5W7W1.1
#=GS Q52PH4_9APHY/2-110    AC Q52PH4.1
#=GS E7FH75_GANMI/2-110    AC E7FH75.1
#=GS E7FH75_GANMI/2-110    DR PDB; 3KCW A; 2-110;
#=GS J8NYG1_BACCE/738-823  AC J8NYG1.1
#=GS K5W7W1_PHACS/4-44     AC K5W7W1.1
#=GS R8TMK4_BACCE/359-450  AC R8TMK4.1
#=GS FVE_FLAVE/1-111       AC P80412.1
#=GS FVE_FLAVE/1-111       DR PDB; 1OSY B; 1-111;
#=GS FVE_FLAVE/1-111       DR PDB; 1OSY A; 1-111;
#=GS M2QVQ0_CERS8/4-101    AC M2QVQ0.1
#=GS J7T287_BACCE/770-885  AC J7T287.1
#=GS B2ZR75_GANLU/2-110    AC B2ZR75.1
#=GS M2PWI3_CERS8/37-130   AC M2PWI3.1
#=GS D2Y6R3_FLAVE/2-112    AC D2Y6R3.1
#=GS J8NAH2_BACCE/685-786  AC J8NAH2.1
#=GS LZ8_GANLU/2-110       AC P14945.2
#=GS LZ8_GANLU/2-110       DR PDB; 3F3H B; 3-110;
#=GS LZ8_GANLU/2-110       DR PDB; 3F3H A; 2-110;
N1LNI9_9BACI/768-862             ....dwaknhvisqwqs---------------------------SKTGYIDGITFSKV...PTTK-VRYQLEIDGKLT..DI.......KPASQVDSQGKRSINFKDFNNGNSIYAGSQI...SVYAVDERNDN---------lkvkvaeh......
N1LHK0_9BACI/767-857             .....kshvvsqwssvq-----------------------------MGYLDGVTFSKV...PN-TKVRYQLEIDGKLT..DI.......KPASQIDSQGKRYINFKDFNNGNSIYAGSQI...SVYAVDEKNDN---------lkvkite.......
C7ZE17_NECH7/5-113               ................n-DSAVLFYIVASQKKLSFDYTPNWGRGSPNSYIDNLTFPRV...LTNKPYKYRVVKAGQDL..GV.......RDSYSVQSDGSQKVNFLEYNAGRGIADTQTI...QVYVVDPDNGN--QYLVAQW..............
R8XTM4_BACCE/770-885             .............lsdl-----------EIQKIYKDTTELWGEDSGSTYLNGVLFKNIepfMGDQVKAYRVVYQGARIpsGIdesfdvtKPAYAYNKDGSVKVNFLEYNKGMGIDFIPTIdsiRIYAVLTD------------nrqvlvyrk.....
M2R9U0_CERS8/4-78                .............rasp---------------------PVWRRGNPTIYVDYVTIPHA...PADKVCQYRVIKSGTDL..GV.......RPTQPLNEDGSQTVKLRQ-------------...--------------------cpalrnqnssfvqk
G5CJT8_9APHY/4-112               ...............tv--TALTFRLAWEVKKISFDYTPNWGRGSPSSYIDNLTFPKV...LTDKAYTYRVVVSGRDL..GV.......RPSYEVASDGSQKINFLEYHNGYGIADTNTI...QVYVVDPSTGD--DFIIAQW..............
K5W7W1_PHACS/41-71               ...............lp-----------------------------------------...-----------------..--.......--------------------KGYGVEQGSTI...QIYAVDPDDGN--QYLIARW..............
Q52PH4_9APHY/2-110               .................SDTALIFRLAWDVKKLSFDYTPTWGRGNPSRFVDNVTFPQV...LADKAYTYRVVVSGRDL..GV.......RPSYAVGSDGSQKVNFLEYNQGYGIADTNTI...QVFVIDPDTDA--DFIIAQW..............
E7FH75_GANMI/2-110               .................SDTALIFTLAWNVKQLAFDYTPNWGRGRPSSFIDTVTFPTV...LTDKAYTYRVVVSGKDL..GV.......RPSYAVESDGSQKINFLEYNSGYGIADTNTI...QVYVIDPDTGN--NFIVAQW..............
#=GR E7FH75_GANMI/2-110    SS    .................--HHHHHHHHHHHS----B---EEEE-SSTTEEEEEEESB-...--SS--EEEEEETTEEE..EE.......E------TTS-EEEEGGGTTTT--EETTS-E...EEEEE-TTT----EEEEEEE..............
J8NYG1_BACCE/738-823             .......gkckysasip-------------------------------LIDGITFPRI...PSTK-VRYQLEIDGKMT..DI.......RSDAVIDASGTRYVNFHKFNNGNGIDMYKRI...IVFAVDEKNDN---------lkakln........
K5W7W1_PHACS/4-44                ................s-SSAALFYLVQIMSRVCFDYTPDWQRGNPNSYIDMVKLPK-...-----------------..--.......-------------------------------...--------------------g.............
R8TMK4_BACCE/359-450             ..laydhgyqswnqvgs-------------------------------YMNGIFFK--...APDSKVRYQIAIDNQPT..VI.......LPGYPLNPQGVRYINFLEFNAGMGIPLNKQI...RVFVVDEKNDNLREQI----afr...........
FVE_FLAVE/1-111                  .................SATSLTFQLAYLVKKIDFDYTPNWGRGTPSSYIDNLTFPKV...LTDKKYSYRVVVNGSDL..GV.......ESNFAVTPSGGQTINFLQYNKGYGVADTKTI...QVFVVIPDTGNSEEYIIAEW..............
#=GR FVE_FLAVE/1-111       SS    .................-HHHHHHHHHHHH-EEEEE---EEEE-SSTTEEEEEEESB-...--SS--EEEEEETTEEE..EE.......E----B-TTS-EEEEGGGTTTT--EETTS-E...EEEEE-TTSTT--EEEEEEE..............
M2QVQ0_CERS8/4-101               ........ewvklvrtn--------------------SATWKRGNPKVYFDHVTLPGV...PTDKAYQYRVVKGDLDL..GT.......RPTYELNKDGSQTINLLEYNKGYGIHEETPI...NVFVVDPEDGM--ETLVAEW..............
J7T287_BACCE/770-885             .............lsdl-----------EIQKIYKDTTELWGEDSGSTYLNGVLFKNIepfMGDQVKAYRVVYQGARIpsGIdesfdvtKPAYAYNKDGSVKVNFLEYNKGMGIDFIPTIdsiRIYAVLTD------------nrqvlvyrk.....
B2ZR75_GANLU/2-110               .................SDTALIFRLAWDVKKLSFDYTPNWGRGNPNNFIDTVIFPKV...LTDKAYTYRVAVSGRNL..GV.......KPSYAVESDGSQKVNFLEYNSGYGIADTNTI...QVFVVDPDTNN--DFIIAQW..............
M2PWI3_CERS8/37-130              ..........lnartpt----------------------IWKRGNPTDYVDHVTLPRV...PADKIYQCRVMKSNLDL..GI.......QPTHPLNEDGSQTINLTEYNKRYGIHDTQNI...KVYVIDPADNT--EKPVAKW..............
D2Y6R3_FLAVE/2-112               .................SATSLTFQLAYLVKKIDFDYTPNWGRGTPSSYIDNLTFPKV...LTDKKYSYRVVVNGSDL..GV.......ESNFAVTPSGGQTINFLQYNKGYGVADTKTI...QVFVVIPDTGNSEEYIIAEW..............
J8NAH2_BACCE/685-786             kgrtvatfkgldyynef---------------------KNWYT-PRSQYVDGVNFSKM...PATK-VRYQLEIDGKLT..EI.......RSDAVSDANGNRLVNFLKFNAGHGISYTKNI...KVYVVDEKNDN---------fkikaa........
LZ8_GANLU/2-110                  .................SDTALIFRLAWDVKKLSFDYTPNWGRGNPNNFIDTVTFPKV...LTDKAYTYRVAVSGRNL..GV.......KPSYAVESDGSQKVNFLEYNSGYGIADTNTI...QVFVVDPDTNN--DFIIAQW..............
#=GR LZ8_GANLU/2-110       SS    .................-HHHHHHHHHHHHSEEEEE---EEEE-SSTTEEEEEEESB-...--SS--EEEEEETTEEE..EE.......E--S---TTS-EEEEHHHHTTT--EETTS-E...EEEEE-TTT----EEEEEEE..............
#=GC SS_cons                     .................-HHHHHHHHHHHHSEEEEE---EEEE-SSTTEEEEEEESB-...--SS--EEEEEETTEEE..EE.......E--S-B-TTS-EEEEGGGTTTT--EETTS-E...EEEEE-TTTTT--EEEEEEE..............
#=GC seq_cons                    .....................................o.sWtRGsPssYlDsVTFP+V....sDKhhpYRVslsGpsl..Gl.......+PsaslsssGopplNFL-YNpGhGIstspsI...pVaVVDscssN..p....................
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