#=GF ID Fve
#=GF AC PF09259.6
#=GF DE Fungal immunomodulatory protein Fve
#=GF AU Sammut SJ
#=GF SE pdb_1osy
#=GF GA 25.00 25.00;
#=GF TC 169.00 168.80;
#=GF NC 24.50 22.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 12948495
#=GF RT A 1.7A structure of Fve, a member of the new fungal
#=GF RT immunomodulatory protein family.
#=GF RA Paaventhan P, Joseph JS, Seow SV, Vaday S, Robinson H, Chua KY,
#=GF RA Kolatkar PR;
#=GF RL J Mol Biol. 2003;332:461-470.
#=GF DR INTERPRO; IPR015339;
#=GF DR SCOP; 1osy; fa;
#=GF CC Fve is a major fruiting body protein from Flammulina velutipes,
#=GF CC a mushroom possessing immunomodulatory activity. It stimulates
#=GF CC lymphocyte mitogenesis, suppresses systemic anaphylaxis
#=GF CC reactions and oedema, enhances transcription of IL-2, IFN-gamma
#=GF CC and TNF-alpha, and haemagglutinates red blood cells. It appears
#=GF CC to be a lectin with specificity for complex cell-surface
#=GF CC carbohydrates. Fve adopts a tertiary structure consisting of an
#=GF CC immunoglobulin-like beta-sandwich, with seven strands arranged
#=GF CC in two beta sheets, in a Greek-key topology. It forms a
#=GF CC non-covalently linked homodimer containing no Cys, His or Met
#=GF CC residues; dimerisation occurs by 3-D domain swapping of the
#=GF CC N-terminal helices and is stabilised predominantly by
#=GF CC hydrophobic interactions [1].
#=GF SQ 8
#=GS Q52PH4_9APHY/2-110 AC Q52PH4.1
#=GS E7FH75_GANMI/2-110 AC E7FH75.1
#=GS E7FH75_GANMI/2-110 DR PDB; 3KCW A; 2-110;
#=GS B2ZR75_GANLU/2-110 AC B2ZR75.1
#=GS G5CJT8_9APHY/4-112 AC G5CJT8.1
#=GS C7ZE17_NECH7/5-113 AC C7ZE17.1
#=GS FVE_FLAVE/1-111 AC P80412.1
#=GS FVE_FLAVE/1-111 DR PDB; 1OSY B; 1-111;
#=GS FVE_FLAVE/1-111 DR PDB; 1OSY A; 1-111;
#=GS D2Y6R3_FLAVE/2-112 AC D2Y6R3.1
#=GS LZ8_GANLU/2-110 AC P14945.2
#=GS LZ8_GANLU/2-110 DR PDB; 3F3H B; 3-110;
#=GS LZ8_GANLU/2-110 DR PDB; 3F3H A; 2-110;
Q52PH4_9APHY/2-110 ..SDTALIFRLAWDVKKLSFDYTPTWGRGNPSRFVDNVTFPQVLADKAYTYRVVVSGRDLGVRPSYAVGSDGSQKVNFLEYNQGYGIADTNTIQVFVIDPDTDA--DFIIAQW
E7FH75_GANMI/2-110 ..SDTALIFTLAWNVKQLAFDYTPNWGRGRPSSFIDTVTFPTVLTDKAYTYRVVVSGKDLGVRPSYAVESDGSQKINFLEYNSGYGIADTNTIQVYVIDPDTGN--NFIVAQW
#=GR E7FH75_GANMI/2-110 SS ..--HHHHHHHHHHHS----B---EEEE-SSTTEEEEEEESB---SS--EEEEEETTEEEEEE------TTS-EEEEGGGTTTT--EETTS-EEEEEE-TTT----EEEEEEE
B2ZR75_GANLU/2-110 ..SDTALIFRLAWDVKKLSFDYTPNWGRGNPNNFIDTVIFPKVLTDKAYTYRVAVSGRNLGVKPSYAVESDGSQKVNFLEYNSGYGIADTNTIQVFVVDPDTNN--DFIIAQW
G5CJT8_9APHY/4-112 tv--TALTFRLAWEVKKISFDYTPNWGRGSPSSYIDNLTFPKVLTDKAYTYRVVVSGRDLGVRPSYEVASDGSQKINFLEYHNGYGIADTNTIQVYVVDPSTGD--DFIIAQW
C7ZE17_NECH7/5-113 .n-DSAVLFYIVASQKKLSFDYTPNWGRGSPNSYIDNLTFPRVLTNKPYKYRVVKAGQDLGVRDSYSVQSDGSQKVNFLEYNAGRGIADTQTIQVYVVDPDNGN--QYLVAQW
FVE_FLAVE/1-111 ..SATSLTFQLAYLVKKIDFDYTPNWGRGTPSSYIDNLTFPKVLTDKKYSYRVVVNGSDLGVESNFAVTPSGGQTINFLQYNKGYGVADTKTIQVFVVIPDTGNSEEYIIAEW
#=GR FVE_FLAVE/1-111 SS ..-HHHHHHHHHHHH-EEEEE---EEEE-SSTTEEEEEEESB---SS--EEEEEETTEEEEEE----B-TTS-EEEEGGGTTTT--EETTS-EEEEEE-TTSTT--EEEEEEE
D2Y6R3_FLAVE/2-112 ..SATSLTFQLAYLVKKIDFDYTPNWGRGTPSSYIDNLTFPKVLTDKKYSYRVVVNGSDLGVESNFAVTPSGGQTINFLQYNKGYGVADTKTIQVFVVIPDTGNSEEYIIAEW
LZ8_GANLU/2-110 ..SDTALIFRLAWDVKKLSFDYTPNWGRGNPNNFIDTVTFPKVLTDKAYTYRVAVSGRNLGVKPSYAVESDGSQKVNFLEYNSGYGIADTNTIQVFVVDPDTNN--DFIIAQW
#=GR LZ8_GANLU/2-110 SS ..-HHHHHHHHHHHHSEEEEE---EEEE-SSTTEEEEEEESB---SS--EEEEEETTEEEEEE--S---TTS-EEEEHHHHTTT--EETTS-EEEEEE-TTT----EEEEEEE
#=GC SS_cons ..-HHHHHHHHHHHHSEEEEE---EEEE-SSTTEEEEEEESB---SS--EEEEEETTEEEEEE--S-B-TTS-EEEEGGGTTTT--EETTS-EEEEEE-TTTTT--EEEEEEE
#=GC seq_cons ..SDTALlFpLAWsVKKLSFDYTPNWGRGsPSSaIDNlTFPKVLTDKAYTYRVVVSG+DLGV+PSYAVpSDGSQKlNFLEYNsGYGIADTNTIQVFVVDPDTGN..-FIIAQW
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