GenomeNet

Database: Pfam
Entry: Fve
LinkDB: Fve
Original site: Fve 
#=GF ID   Fve
#=GF AC   PF09259.9
#=GF DE   Fungal immunomodulatory protein Fve
#=GF AU   Sammut SJ
#=GF SE   pdb_1osy
#=GF GA   25.00 25.00;
#=GF TC   48.90 25.20;
#=GF NC   20.50 18.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   12948495
#=GF RT   A 1.7A structure of Fve, a member of the new fungal
#=GF RT   immunomodulatory protein family. 
#=GF RA   Paaventhan P, Joseph JS, Seow SV, Vaday S, Robinson H, Chua KY,
#=GF RA   Kolatkar PR; 
#=GF RL   J Mol Biol. 2003;332:461-470.
#=GF DR   INTERPRO; IPR015339;
#=GF DR   SCOP; 1osy; fa;
#=GF CC   Fve is a major fruiting body protein from Flammulina velutipes,
#=GF CC   a mushroom possessing immunomodulatory activity. It stimulates
#=GF CC   lymphocyte mitogenesis, suppresses systemic anaphylaxis
#=GF CC   reactions and oedema, enhances transcription of IL-2, IFN-gamma
#=GF CC   and TNF-alpha, and haemagglutinates red blood cells. It appears
#=GF CC   to be a lectin with specificity for complex cell-surface
#=GF CC   carbohydrates. Fve adopts a tertiary structure consisting of an
#=GF CC   immunoglobulin-like beta-sandwich, with seven strands arranged
#=GF CC   in two beta sheets, in a Greek-key topology. It forms a
#=GF CC   non-covalently linked homodimer containing no Cys, His or Met
#=GF CC   residues; dimerisation occurs by 3-D domain swapping of the
#=GF CC   N-terminal helices and is stabilised predominantly by
#=GF CC   hydrophobic interactions [1].
#=GF SQ   8
#=GS A0A067MEZ4_9HOMO/4-111  AC A0A067MEZ4.1
#=GS K5W7W1_PHACS/4-44       AC K5W7W1.1
#=GS C7ZE17_NECH7/5-113      AC C7ZE17.1
#=GS M2QVQ0_CERS8/4-101      AC M2QVQ0.1
#=GS M2R9U0_CERS8/4-78       AC M2R9U0.1
#=GS M2PWI3_CERS8/37-130     AC M2PWI3.1
#=GS A0A084QD05_9HYPO/3-111  AC A0A084QD05.1
#=GS K5W7W1_PHACS/41-71      AC K5W7W1.1
A0A067MEZ4_9HOMO/4-111             ........d-TTAQIFHLVASLPKLSYDYTPNWVKD--RQYINSVTFAKVLADKAYTYRVMAGDKDLGVKPSYAVGSDGSQKINFLEYNGGYGIDgNANTVYVYVVDPETGN--QYKIAQ-s.............
K5W7W1_PHACS/4-44                  ........s-SSAALFYLVQIMSRVCFDYTPDWQRGNPNSYIDMVKLPK----------------------------------------------.-------------------------g.............
C7ZE17_NECH7/5-113                 ........n-DSAVLFYIVASQKKLSFDYTPNWGRGSPNSYIDNLTFPRVLTNKPYKYRVVKAGQDLGVRDSYSVQSDGSQKVNFLEYNAGRGIA.DTQTIQVYVVDPDNGN--QYLVAQW..............
M2QVQ0_CERS8/4-101                 ewvklvrtn--------------------SATWKRGNPKVYFDHVTLPGVPTDKAYQYRVVKGDLDLGTRPTYELNKDGSQTINLLEYNKGYGIH.EETPINVFVVDPEDGM--ETLVAEW..............
M2R9U0_CERS8/4-78                  .....rasp---------------------PVWRRGNPTIYVDYVTIPHAPADKVCQYRVIKSGTDLGVRPTQPLNEDGSQTVKLRQ--------.-------------------------cpalrnqnssfvqk
M2PWI3_CERS8/37-130                ..lnartpt----------------------IWKRGNPTDYVDHVTLPRVPADKIYQCRVMKSNLDLGIQPTHPLNEDGSQTINLTEYNKRYGIH.DTQNIKVYVIDPADNT--EKPVAKW..............
A0A084QD05_9HYPO/3-111             .....apty----LLVPFVTAVGKINVDYTPNWGRGSPSSYIDNVKFPRVLTDRQYKYRVVKGSTDLGVRDAYAIESDGSQKINFLEYNSGRGIE.DSTAIKIYIVEPDTGN--QSLLVQW..............
K5W7W1_PHACS/41-71                 .......lp--------------------------------------------------------------------------------KGYGVE.QGSTIQIYAVDPDDGN--QYLIARW..............
#=GC seq_cons                      ........s....................oPsWtRGsPssYlDpVThP+V.sDK.YpYRVhKushDLGl+soaslppDGSQplNhhEYNtGhGIc.pspsIplYlVDP-sGs..phhlApW..............
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