GenomeNet

Database: Pfam
Entry: GP41
LinkDB: GP41
Original site: GP41 
#=GF ID   GP41
#=GF AC   PF00517.15
#=GF DE   Retroviral envelope protein
#=GF AU   Finn RD, Bateman A
#=GF SE   Pfam-B_44 (release 1.0)
#=GF GA   27.90 27.90;
#=GF TC   28.10 29.80;
#=GF NC   27.20 27.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Gp41
#=GF RN   [1]
#=GF RM   9689046
#=GF RT   Crystal structure of the simian immunodeficiency virus (SIV)
#=GF RT   gp41 core: conserved helical interactions underlie the broad
#=GF RT   inhibitory activity of gp41 peptides. 
#=GF RA   Malashkevich VN, Chan DC, Chutkowski CT, Kim PS; 
#=GF RL   Proc Natl Acad Sci USA 1998;95:9134-9139.
#=GF DR   INTERPRO; IPR000328;
#=GF DR   SCOP; 2siv; fa;
#=GF DR   HOMSTRAD; GP41;
#=GF CC   This family includes envelope protein from a variety of
#=GF CC   retroviruses. It includes the GP41 subunit of the envelope
#=GF CC   protein complex from human and simian immunodeficiency viruses
#=GF CC   (HIV and SIV) which mediate membrane fusion during viral entry.
#=GF CC   The family also includes bovine immunodeficiency virus, feline
#=GF CC   immunodeficiency virus and Equine infectious anaemia (EIAV). The
#=GF CC   family also includes the Gp36 protein from mouse mammary tumour
#=GF CC   virus (MMTV) and human endogenous retroviruses (HERVs).
#=GF SQ   57
#=GS EN113_HUMAN/486-683      AC Q902F9.1
#=GS H0XK29_OTOGA/44-131      AC H0XK29.1
#=GS M3WQG5_FELCA/339-506     AC M3WQG5.1
#=GS ENV_MMTVC/477-670        AC Q85646.1
#=GS H0VX62_CAVPO/396-534     AC H0VX62.1
#=GS A0A091EEM2_FUKDA/56-151  AC A0A091EEM2.1
#=GS ENK13_HUMAN/310-482      AC Q9NX77.2
#=GS K7E540_MONDO/157-335     AC K7E540.1
#=GS M3Z7H6_MUSPF/180-279     AC M3Z7H6.1
#=GS K7E5W9_MONDO/457-565     AC K7E5W9.1
#=GS H0W7P8_CAVPO/396-534     AC H0W7P8.1
#=GS W5NV54_SHEEP/130-266     AC W5NV54.1
#=GS W5Q3H7_SHEEP/211-306     AC W5Q3H7.1
#=GS H0Y1E9_OTOGA/44-239      AC H0Y1E9.1
#=GS J9P2Q7_CANLF/401-572     AC J9P2Q7.1
#=GS ENK9_HUMAN/485-682       AC Q9UKH3.1
#=GS W5PYE6_SHEEP/399-601     AC W5PYE6.1
#=GS ENK24_HUMAN/375-572      AC P61566.1
#=GS K7E0Y0_MONDO/457-582     AC K7E0Y0.1
#=GS K7E362_MONDO/457-641     AC K7E362.1
#=GS A0A091EEJ4_FUKDA/70-239  AC A0A091EEJ4.1
#=GS J9P8P5_CANLF/193-386     AC J9P8P5.1
#=GS ENK8_HUMAN/486-683       AC Q902F8.1
#=GS ENK25_HUMAN/486-660      AC P61570.1
#=GS K7EC13_ORNAN/90-286      AC K7EC13.1
#=GS W5PX43_SHEEP/478-667     AC W5PX43.1
#=GS M3WQW5_FELCA/411-605     AC M3WQW5.1
#=GS K7E3F8_MONDO/464-534     AC K7E3F8.1
#=GS ENK19_HUMAN/486-683      AC O71037.2
#=GS G3IC96_CRIGR/149-334     AC G3IC96.1
#=GS G3HPN4_CRIGR/113-296     AC G3HPN4.1
#=GS H0VWG6_CAVPO/393-531     AC H0VWG6.1
#=GS W5NXJ9_SHEEP/302-489     AC W5NXJ9.1
#=GS ENK18_HUMAN/375-555      AC O42043.2
#=GS W5QFH9_SHEEP/399-601     AC W5QFH9.1
#=GS ENK7_HUMAN/375-572       AC P61567.1
#=GS ENV_HV2BE/528-727        AC P18094.1
#=GS H0W3V5_CAVPO/404-542     AC H0W3V5.1
#=GS W5PHC7_SHEEP/37-232      AC W5PHC7.1
#=GS ENK6_HUMAN/486-683       AC Q69384.1
#=GS ENV_HV1H2/530-723        AC P04578.2
#=GS ENV_HV1H2/530-723        DR PDB; 2MG3 A; 8-26;
#=GS ENV_HV1H2/530-723        DR PDB; 1MZI A; 1-13;
#=GS ENV_HV1H2/530-723        DR PDB; 4YDV P; 596-606;
#=GS ENV_HV1H2/530-723        DR PDB; 1GZL B; 29-45;
#=GS ENV_HV1H2/530-723        DR PDB; 1K33 A; 1-66;
#=GS ENV_HV1H2/530-723        DR PDB; 1GZL A; 29-45;
#=GS ENV_HV1H2/530-723        DR PDB; 1AIK N; 546-581;
#=GS ENV_HV1H2/530-723        DR PDB; 5CN0 A; 3-36;
#=GS ENV_HV1H2/530-723        DR PDB; 5CMU C; 1-50;
#=GS ENV_HV1H2/530-723        DR PDB; 3D0V C; 1-9;
#=GS ENV_HV1H2/530-723        DR PDB; 5CMZ A; 3-45;
#=GS ENV_HV1H2/530-723        DR PDB; 1DLB A; 2-66;
#=GS ENV_HV1H2/530-723        DR PDB; 2ME1 A; 657-683;
#=GS ENV_HV1H2/530-723        DR PDB; 4YDV Q; 596-606;
#=GS ENV_HV1H2/530-723        DR PDB; 2MG1 A; 3-24;
#=GS ENV_HV1H2/530-723        DR PDB; 5CMZ C; 1-45;
#=GS ENV_HV1H2/530-723        DR PDB; 1GZL C; 628-639;
#=GS ENV_HV1H2/530-723        DR PDB; 5CIN P; 671-683;
#=GS ENV_HV1H2/530-723        DR PDB; 2PV6 A; 662-683;
#=GS ENV_HV1H2/530-723        DR PDB; 2XRA A; 543-4580;
#=GS ENV_HV1H2/530-723        DR PDB; 1GZL D; 628-639;
#=GS ENV_HV1H2/530-723        DR PDB; 3VIE E; 35-70;
#=GS ENV_HV1H2/530-723        DR PDB; 5CMU B; 1-50;
#=GS ENV_HV1H2/530-723        DR PDB; 1DF5 A; 1-68;
#=GS ENV_HV1H2/530-723        DR PDB; 1K34 A; 2-66;
#=GS ENV_HV1H2/530-723        DR PDB; 3VIE A; 35-69;
#=GS ENV_HV1H2/530-723        DR PDB; 1AIK C; 628-661;
#=GS ENV_HV1H2/530-723        DR PDB; 3VIE C; 35-70;
#=GS ENV_HV1H2/530-723        DR PDB; 5CIL P; 671-683;
#=GS ENV_HV1H2/530-723        DR PDB; 5CMU A; 1-50;
#=GS ENV_HV1H2/530-723        DR PDB; 2MG2 A; 8-26;
#=GS ENV_HV1H2/530-723        DR PDB; 5C0S A; 145-136;
#=GS ENV_HV1H2/530-723        DR PDB; 5C0R A; 145-136;
#=GS ENV_HV1H2/530-723        DR PDB; 1DF4 A; 3-64;
#=GS H0WC04_CAVPO/347-539     AC H0WC04.1
#=GS K7DYS2_MONDO/457-641     AC K7DYS2.1
#=GS M3X037_FELCA/404-593     AC M3X037.1
#=GS W5Q6Q5_SHEEP/399-601     AC W5Q6Q5.1
#=GS H0VXU3_CAVPO/388-526     AC H0VXU3.1
#=GS W5QF72_SHEEP/399-595     AC W5QF72.1
#=GS W5PBV3_SHEEP/400-602     AC W5PBV3.1
#=GS ENK21_HUMAN/485-682      AC P61565.1
#=GS G1TXI8_RABIT/42-230      AC G1TXI8.1
#=GS W5NUA7_SHEEP/138-319     AC W5NUA7.1
#=GS M3Z4E0_MUSPF/82-251      AC M3Z4E0.1
#=GS K7E601_MONDO/457-641     AC K7E601.1
#=GS POK7_HUMAN/1246-1443     AC P63135.1
#=GS M3Y078_MUSPF/44-147      AC M3Y078.1
#=GS K7E1I1_MONDO/157-361     AC K7E1I1.1
#=GS K7E1W5_MONDO/457-632     AC K7E1W5.1
EN113_HUMAN/486-683                 ....VAGVALHS.SV.......QSVNFVNDW...QNNSTRLWNSQSSI.......DQKLANQINDLRQTVIWMGDRLMSLEHRFQLQ...CDWNTSDFCITPQIY.NESE..hHWD.MVRCHLQG--RED.......NLTLDISKLKEQIFEASKAHLNLV...PGTEAIAGVADGLAN-LNTVT....WVKTI.GST...-TIINLIL-ILVCLFCLLLV.......yRC-TQQLRRDSD.HrE..RAMMTMVVLSKRK-g...................................
H0XK29_OTOGA/44-131                 ..va-AKIAVST.SL.......QTAHTLNNL...SALTAQALDSQQLV.......NTHLKLAILNLNQQTFLLQEQVELLWNLQGVS...CLPPFNSICVTPWKV.K---...---.-------------.......------------------------...---------------------....-----.---...--------------------........------------.-.-..--------------naskvi..............................
M3WQG5_FELCA/339-506                ....VSVISLRE.SA.......QTASHVNEL...AHHVSKVFATQERI.......DRKLEAQLEALQEALMYLGDQFAVLRTRLSLI...CHDAYKHICVTPLEY.-TNV...TWG.QV-RHLQGVWYDA.......NTSLDLLQLQEEINAVASSSLSFP...D-PGDLSETTLHQLNGFNPFN....ILQHSfWIF...IGIVSVISVILV---LL---........------------.-.-..--------------cyf.................................
ENV_MMTVC/477-670                   ....VATTALVK.EM.......QTATFVNNL...HRNVTLALSEQRII.......DLKLEARLNALEEVVLDLGQDVANLKTRMSTR...CHANYDFICVTPLPY.NASE...SWE.RTKAHLLGIWNDN.......EISYNIQELTNLIGDMSKQHIDTV...D----LSGLAQSFANGVKALNp.ldWTQY-.---...--FIFIGVGALLLVIVLMIF........PIVFQCLAKSLD.Q.V..QSDLNVLLLKKKKG....................................
H0VX62_CAVPO/396-534                ....VSGIALQT.SL.......QEKHVVEHW...HENSHELWLTQWQI.......NAKLQQQIDLLKQTVGWMERKLLALQHQVFLK...CDWNSTIFCITQRPY.SQTK..rEWE.VIKMYLNG---NT.......SAQEEIESLHNQIDKDFAKHYDDE...S----LAQFAQLLAH------....-----.---...--------------------........------------.-.-..--------------slegld..............................
A0A091EEM2_FUKDA/56-151             ....TSAVALTG.TL.......QNSANINDL...QNTTTTALRTQQRI.......NPHIGTGLAILQQQMDLFNEEVEGLWLHTRLD...CDPRFQQLCLTPFPVkNHSE...EVR.R------------.......------------------------...---------------------....-----.---...--------------------........------------.-.-..--------------lssllrg.............................
ENK13_HUMAN/310-482                 ...t-AGVAIRS.SV.......QTAHYVEAC...QKNSSRLWNSQAQI.......DQKLANQINDLRQSVTWLGDRVMNLQHRMQLQ...CDWNTSDYCITPYAY.NQDQ..hSWE.NVSRHLK-AWDD-.......NLTLDISQLKEQIFEASQAHLSTV...PGSHIFEGITKQLPD-FNPFK....WLKPV.RGS...LLLLALLI--LVCLCCLLL-........------------.-.-..--------------vcrcl...............................
K7E540_MONDO/157-335                ....VSSVSLAQ.SVanvrtleHDAEYLHRL...AQNVTQVLHLQQDI.......NTRVFYALQQISKDVLLLTNQVEILAIKGKLR...CDYRYSAFCLLPVKA.NRSD...VFE.EIRNDLQGLWLKG.......NISEDIQQLNHIIDEMDNSLAEDL...R----PEHIADSLYSWIKSGQ...sWLS--.PLA...QMSITILTFILFIVILVILL........PCLF--------.-.-..--------------....................................
M3Z7H6_MUSPF/180-279                ...a-AAVSLAA.TI.......PTAEAVNTL...AEGTVAALQTQTQI.......TAHLQAGILIVNQRVDLVQEQVDILGALLGLG...CIAPFLAICVTPIAY.TNMS...DLQ.NVSQQLSQ-----.......------------------------...---------------------....-----.---...--------------------........------------.-.-..--------------ylwgn...............................
K7E5W9_MONDO/457-565                ....TATLALTS.SI.......QNHEFIQEV...VSNSSKLWHTQQSI.......DLAYRDELDSLKDAVFWLGKEVEALHTRITYP...CHYNQTGYCITPLPY.DNVS..yEWQ.LVVQHIKGAWE--.......------------------------...---------------------....-----.---...--------------------........------------.-.-..--------------vitapwtlls..........................
H0W7P8_CAVPO/396-534                ....VSGIALQT.SL.......QEKHVVEHW...HENSHELWLTQWQI.......NTKLQQQIDLLKQTVEWMERKLLALQHQVFLK...CDWSSTIFCITQRPY.SQTK..rEWE.VIKMYLNG---NT.......SAQEEIESLHNQIDKDFAKHYDDE...S----LAQFAQLLAH------....-----.---...--------------------........------------.-.-..--------------slegld..............................
W5NV54_SHEEP/130-266                ....TASVSLAQ.SI.......QAAHTVDSL...SYNVTKVMGTQEDI.......DKKIEDRLSALYDVVRVLGEQVQSINFRMKIQ...CHANYKWICVTKKPY.NTSD..fPWD.KVKKHLQGIWFNT.......NVSLDLLQLHNEILDIENSPKATL...NIADTVG--------------....-----.---...--------------------........------------.-.-..--------------atlac...............................
W5Q3H7_SHEEP/211-306                ....TASVSLAQ.SI.......QAAHTVDSL...SYNVTKVMGTQEDI.......DKKIEDRLSALYDVVRVLGEQVQSINFRMKIQ...CHANYKWICVTKKPY.NTSD..fPWD.-------------.......------------------------...---------------------....-----.---...--------------------........------------.-.-..--------------iedrlsyy............................
H0Y1E9_OTOGA/44-239                 vatg---IAIST.SV.......QTDNILNNL...NALTAQALDTQQQI.......NAHLRLAILNLNQQTFLLQEQVDLLWNLQGVS...CLPPFNSICVTPWKVkNASE...AVK.TLNNYIKEGWSPA.......-FDNYTRNLLHTIRVINETKVPTI...T----GDTFLQSLTSFWSLIR...sWGGTV.AMF...LLISLISLA-----------........------------.-.-..--------------flrvlwkrvvttrkhqillaqalhnptnkvwvslih
J9P2Q7_CANLF/401-572                ...a-ASVALSQ.GI.......QTAQYVNNL...AKNVSYALSTQERI.......DQKILSCLDGLEEEVKFLGNQLSQLKTQMSLV...CHGGFQHICVTPMKA.-T-N..vTWG.QVKKHLQGIWFHS.......NMSLDLLELQKEISSISHSQRGMT...NPAEIMAHILDGL-HGFNPGN....LLKHS.FWM...FIIIFTIVMI----------........------------.-.-..--------------lffawprivkl.........................
ENK9_HUMAN/485-682                  ....VAGVALHS.SV.......QSVNFVNDG...QKNSTRLWNSQSSI.......DQKLANQINDLRQTVIWMGDRLMSLEHRFQLQ...CDWNTSDFCITPQIY.NESE..hHWD.MVRRHLQG--RED.......NLTLDISKLKEQIFEASKAHLNLV...PGTEAIAGVADGLANLNPV-T....WVKTI.GST...-TIINLI-LILVCLFCLLLV........CRCTQQLRRDSD.H.R.eRAMMTMAVLSKRK-g...................................
W5PYE6_SHEEP/399-601                ....TASVSLAQ.SI.......QAAHTVDSL...SYNVTKVMGTQEDI.......DKKIEDRLSALYDVVRVLGEQVQSINFRMKIQ...CHANYKWICVTKKPY.NTSD..fPWD.KVKKHLQGIWFNT.......NVSLDLLQLHNEILDIENSPKATL...NIADTVDNFLQNLFSNFPSLHs..lWRS--.---...--IIAMGAVLTVVLIIICLA........PCLIRSIVKEFL.H.M..RVLIHKNMLQHQ--hlmellkn............................
ENK24_HUMAN/375-572                 ....VAGVALHS.SV.......QSVNFVNDW...QKNSTRLWNSQSSI.......DQKLANQINDLRQTVIWMGDRLMSLEHRFQLQ...CDWNTSDFCITPQIY.NESE..hHWD.MVRHHLQG--RED.......NLTLDISKLKEQIFEASKAHLNLV...PGTEAIAGVADGLANLNPV-T....WVKTI.GST...-TIINLI-LILVCLFCLLLV........CRCTQQLRRDSD.H.R.eRAMMTMAVLSKRK-g...................................
K7E0Y0_MONDO/457-582                ....TATLALTS.SI.......QNHEFIQEV...VSNSSKLWHTQQSI.......DLAYRDELDSLKDAVFWLGKEVEALHTRITYP...CHYNQTGYCITPLPY.DNVS..yEWQ.LIVQHIKGAWGSH.......NSTLDIIKLQQQINRLDQ------...---------------------....-----.---...--------------------........------------.-.-..--------------ivyenea.............................
K7E362_MONDO/457-641                ....TATLALTS.SI.......QNHEFIQEV...VSNSSKLWHTQQSI.......DLAYRDELDSLKDAVFWLGKEVEALHTRITYP...CHYNQTGYCITPLPY.DNVS..yEWQ.LVVQHIKGAWGSH.......NSTLDIIKLQQQINKLDQIVYENE...A-ANIAANWE-ATLSSLDPQN....WFGRA.NLT..sIGTIILFILLAIGLIILC--........------------.-.-..--------------srscknrayirgil......................
A0A091EEJ4_FUKDA/70-239             ....TSAVALTG.TL.......QNTATINDL...QNTTTMALRTQQRI.......NPHIGTGLAILQQQMDLLNEEVEGLWLHTRLD...CDPRFQQLCLTPFPVkNHSE...EVR.RLSSLLRGSWNRT.......FLNA-TNQLSLDIDILSGVHANSI...R--LNLD-FATEVWENLKKMFs.psWIV--.-IW...LIVIAVMIGLCILGY-----........------------.-.-..--------------csyrc...............................
J9P8P5_CANLF/193-386                ...a-ASVALSQ.GI.......QTAQYVNHL...AKNISYALSTQERV.......DQKVLSRLDGLEEAVEFPGNQLSLFKTQMSLV...CHGGFQHICVTPIKA.-T-N..vTWG.QVKKHLPGIWFHS.......NISLNLLKLQKKISIISHSQIGVT...NPAKMVAHILDGL-HGFNPGN....LLRYS.FWM...FI-----IVFTIMII-SFFA........WCVVQAKARQHRfS.M..DAQLHFLNLKTKKG....................................
ENK8_HUMAN/486-683                  ....VAGVALHS.SV.......QSVNFVNDG...QKNSTRLWNSQSSI.......DQKLANQINDLRQTVIWMGDRLMSLEHRFQLQ...CDWNTSDFCITPQIY.NDSE..hHWD.MVRRHLQG--RED.......NLTLDISKLKEQIFEASKAHLNLV...PGTEAIAGVADGLANLNPV-T....WVKTI.GST...-TIINLI-LILVCLFCLLLV........CRCTQQLRRDSD.H.R.eRAMMTMAVLSKRK-g...................................
ENK25_HUMAN/486-660                 ....VAGVALHS.SV.......QSVNFVNDW...QKNSTRLWNSQSSI.......DQKLANQINDLRQTVIWMGDRLMSLEHRFQLQ...CDWNTSDFCITPQIY.NESE..hHWD.MVRRHLQG--RED.......NLTLDISKLKEQIFKASKAHLNLV...PGTEAIAGVADGLANLNPV-T....WVKTI.GST...T-IINLI-LILVCLFCLLLV........------------.-.-..--------------crctqq..............................
K7EC13_ORNAN/90-286                 ....VSTLSLQT.EI.......HTAGYVNEL...AHNVNLAFQAQERI.......DRDLLYKINLLEQSVLYLGTEIETLKEKLSLQ...CDCRYLYVWVTPVKY.NASDenlSWD.KIKNRMLGAWHQS.......KITLAMDQLRKITEEIENSPHLNE...H----PEVIARIVLDSLKQLNp.fnWVSI-.G--...---LQTLPYIFVFIMVLQMF........PLITRFLATTLK.I.L..LTQLYELRLVNKKG....................................
W5PX43_SHEEP/478-667                ....VAAISLTQ.QV.......HTAQYVDTM...SKNVSLTLATQEVI.......DRKLEMKVDALEEAITHIGTELQALKVKLTLS...CRADYRWIWVTPLKV.NETD..yNWE.KIRNHVSRVWNSS.......SISLDLGKLHNQITTMEHSRLDFT...A-AGAANDFFHTFSNFISGKN....ILS--.---...AVFSYVAVGALILLLI-IIL........PCIVRIIRQSIQ.K.L..ATELHLAVL-----....................................
M3WQW5_FELCA/411-605                ....VSTIALAQ.EV.......HTAHFTNEL...SKNVTTALTTQEII.......DRKLDDKVNVLEEAVMAIGQEILTLKIQLSLR...CHSDYKWICVTPLRV.NESE..hNWE.RVQSHILGVWNHS.......DLGIDLSKLHKQISDINHASEEFS...P-----EGIAQSLYDNFSS--....WVSGS.SLT...TLLINVGVALLVLLICLLLI........PVFFKVLARSLQ.K.L..TAEVQLLALKNKKG....................................
K7E3F8_MONDO/464-534                ....TATLALTS.SI.......QNHEFIQEV...VSNSSKLWHTQQSI.......DLAYRDELDSLKDAVFWLGKEVEALHTRITYP...CHYN-----------.----...---.-------------.......------------------------...---------------------....-----.---...--------------------........------------.-.-..--------------qt..................................
ENK19_HUMAN/486-683                 ....VAGVALHS.SV.......QSVNFVNDW...QKNSTRLWNSQSSI.......DQKLANQINDLRQTVIWMGDRLMSLEHRFQLQ...CDWNTSDFSITPQIY.NESE..hHWD.MVRRHLQG--RED.......NLTLDISKLKEQIFEASKAHLNLV...PGTEAIAGVADGLANLNPV-T....WVKTI.GST...-TIINLI-LILVCLFCLLLV........CRCTQQLRRDSD.H.R.eRAMMTMAVLSKRK-g...................................
G3IC96_CRIGR/149-334                ....VSAVTLSG.TV.......QTDSALNNL...SANVAHALGLQTSL.......NSQIKGGLMIVNQRIDLVQEQLDTLWQLAQLG...CEWKMPGLCVTSVQY.TNYM...RAA.ELARSLSAYLFQNw....slEFEDTLKVLRLAVVNVNSTQVDLS...L-ATGLSSWLNSAMDHLKE--....WAGL-.---...----GVLTGLLILVSLICL-........------------.-.-..--------------wyiykirvtqkqdaamiaqafv..............
G3HPN4_CRIGR/113-296                ....VSAVSLSG.TV.......QTASALNNL...SANVSHALDLQTSL.......NSQIKGGLMIVNQRIDLVQEQLDTLWQLAQLG...CEWKMPGLCVTSVQY.TNYT..rAAE.L-VRSLSAYLFQNr....slEFEDTLKELRLAVVNVNSTRVDLS...L-ATGLSSWLDSAMDHLKE--....WAGLG.ALT...GLLILV--------SLI---........------------.-.-..--------------clwciykirvtqkrdaamiaqa..............
H0VWG6_CAVPO/393-531                ...v-SEIALQT.SL.......QEKHVVKLW...HENSHELWLTQWQI.......NAKLQQQIDLLKQTVEWMGRKILALQHQVFLK...CDWNSTTFCITQRPY.NQTE..yEWE.VIRMYLNG---NT.......SAQEEIESLHNQIDKDFTKQNDDE...S----LAQFAQLLAQSL----....-----.---...--------------------........------------.-.-..--------------kgld................................
W5NXJ9_SHEEP/302-489                ....VAAISLTQ.QV.......HTAQYVDTI...SKNVLLVLATQEAI.......DRKLEMRVDTLEEATMRIGTELRTLKVKMTFS...CHADYWWICVMPLKV.NETD..yDWE.KL-KHISGVWNSS.......DTGLDLGKFHNHIKTMENSCAKGV...P-----NDIFYTFFNFISGKN....MLS--.---...-TIFSYAAVAAVILLLIIIL........PCIVRILQESIQ.K.V..TTELHLAVLRNK--....................................
ENK18_HUMAN/375-555                 ....VAGVALHS.SV.......QSVNFVNYW...QKNSTRLWNSQSSI.......DQKLASQINDLRQTVIWMGDRLMTLEHHFQLQ...CDWNTSDFCITPQIY.NESE..hHWD.MVRRHLQG--RED.......NLTLDISKLKEQIFEASKAHLNLV...PGTEAIAGVADGLANLNPV-T....WIKTI.RST...-MIINLIL-IVVCLFCLLLV........------------.-.-..--------------crctqqlrrdsd........................
W5QFH9_SHEEP/399-601                ....TASVSLAQ.SI.......QAAHTVDSL...SYNVTKVMGTQENI.......DKKIEDRLSALYDVVRVLGEQVQSINFRMKIQ...CHANYKWICVTKKPY.NTSD..fPWD.KVKKHLQGIWFNT.......TVSLDLLQLHNEILDIENSPKATL...NIADTVDNFLQNLFSNFPSLHs..lWRS--.---...--IIAMGAVLTVVLIIICLA........PCLIRSIVKEFL.H.M..RVLIHKNMLQHQ--hlmellkn............................
ENK7_HUMAN/375-572                  ....VAGVALHS.SV.......QSVNFVNDW...QKNSTRLWNSQSSI.......DQKLANQINDLRQTVIWMGDRLMSLEHRFQLQ...CDWNTSDFCITPQIY.NESE..hHWD.MVRRHLQG--RED.......NLTLDISKLKEQIFEASKAHLNLV...PGTEAIAGVADGLANLNPV-T....WVKTI.GST...-TIINLI-LILVCLFCLLLV........CRCTQQLRRDSD.H.R.eRAMMTMAVLSKRK-g...................................
ENV_HV2BE/528-727                   ....MGARSLTL.SA.......QSRTLLAGIvqqQQQLLDVVKRQQEMlrltvwgTKNLQARVTAIEKY----------LKHQAQLNswgC--AFRQVCHTTVPW.----...---.-VNDSLSPDWKNMtwqewekQVRYLEANISQSLEEAQIQQEKNM...YELQKLNSWD-ILGNWFDLTS....WVKYI.QYG...VHIVVGIIALRIAIYVVQLLsrfrkgyrPV-FSSPPGYLQ.Q.I..H--I-----HK---drg.................................
H0W3V5_CAVPO/404-542                ....VSGIALQT.SL.......QEKHVVELW...HENSHELWLTQWQI.......NAKLQQQIDLLKQTVEWMGRKILALQHQVFLK...CDWNSTTFCITQRPY.NQTE..hEWE.VIKMYLNG---NT.......SAQEEIESLHNQIDKDFAKQNDDE...S----LAQFAQLLAQSL----....-----.---...--------------------........------------.-.-..--------------kgld................................
W5PHC7_SHEEP/37-232                 ....VAGLALHQ.GI.......QTADFVREW...HKDAHLLWQQQHDL.......DAQLATDVLNLQHTVSWLGDQVTVLATKSVLK...CDWNSSHLCVTPVPL.NMSE...GWK.KVKRSLVG---HQ.......NLTAEIMELEQTILSTFS---KTL...PDILGS-DILKSLQEGLDNLNp.lgHVS-T.LLT...TSFVNTLLIVALCFIAFIV-........------------.-.-..--------------yrrwrkgkqlkeealhiqaliqhlqekkg.......
ENK6_HUMAN/486-683                  ....VAGVALHS.SV.......QSVNFVNDW...QKNSTRLWNSQSSI.......DQKLANQINDLRQTVIWMGDRLMSLEHRFQLQ...CDWNTSDFCITPQIY.NESE..hHWD.MVRRHLQG--RED.......NLTLDISKLKEQIFEASKAHLNLV...PGTEAIAGVADGLANLNPV-T....WVKTI.GST...-TIINLI-LILVCLFCLLLV........CRCTQQLRRDSD.H.R.eRAMMTMAVLSKRK-g...................................
ENV_HV1H2/530-723                   ....MGAASMTL.TV.......QARQLLSGIvqqQNNLLRAIEAQQHLlqltvwgIKQLQARILAVERY----------LKDQQLLGiwgC--SGKLICTTAVPW.NA--...SW-.-SNKSLEQIWNHTtwmewdrEINNYTSLIHSLIEESQNQQEKNE...QELLELDKWA-SLWNWFNITN....WLWYI.KLF...IMIVGGLVGLRIVFAVLSIVnrvrqgysPLSFQT------.-.-..--------------hlpt................................
#=GR ENV_HV1H2/530-723        SS    ....XXXXXXXX.XX.......XXXXHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSCHH----------HHHHHHHHHHEE--CCSHHHCXXXXX.XX--...XX-.-HHHHHHHHHHXHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH...HHHTCHHHHH-HHHHHGCHHH....HHHHH.HHH...HHHHHHHCHHHHHHHHHHHXXXXXXXXXXXXXXX------.-.-..--------------XXXX................................
H0WC04_CAVPO/347-539                ....VSGIALQT.SL.......QEKHVVELW...HENSHELWLTQWQI.......NARLQQQIDLLKQTVEWMGKKILALQHQVFLK...CDWNSTTFCITQRPY.NQTE..hEWE.MIRMYLNG---NT.......SAQEEIESLHNQIDKDFAKQNDDE...S----LAQFAQLLAQSLKGLDskgiWQS--.---...ITHTFSGMGLSLIIVLIAIV........LVYFYCIRRNTI.N.N..L-ILWKLLLKNKK-e...................................
K7DYS2_MONDO/457-641                ....TATLALTS.SI.......QNHEFIQEV...VSNSSKLWHTQQSI.......DLAYRDELDSLKDAVFWLGKEVEALHTRITYP...CHYNQTGYCITPLPY.DNVS..yEWQ.LVVQHIKGAWGSH.......NSTLDIIKLQQQINKLDQIVYENE...A-ANIAANWE-ATLSSLDPQN....WFGRA.NLT..sIGTIILFILLAIGLIILC--........------------.-.-..--------------srscknrayirgil......................
M3X037_FELCA/404-593                ....VSVISLHE.SA.......QTASHVNEL...AHNVSKVFATQERI.......DRKLEAQLEALQEALISLGDQFAVLHTRLSLI...CHDAYKHICVTPLEY.-TNM...TWG.HVRRHLQGIWHDA.......NTSLDLLQLQEEINAIASSSLSFP...D-PGSLAGTILHQLNGFNPFN....ILQH-.---...SFWIFIGIVSVIS-VILVLL........CCFWRWGLTAFT.T.Y..QARIHMLQ------lq..................................
W5Q6Q5_SHEEP/399-601                ....TASVSLAQ.SI.......QAAHTVDSL...SYNVTKVMGTQENI.......DKKIEDRLSALYDVVRVLGEQVQSINFRMKIQ...CHANYKWICVTKKPY.NTSD..fPWD.KVKKHLQGIWFNT.......TVSLDLLQLHNEILDIENSPKATL...NIADTVDNFLQNLFSNFPSLHs..lWRS--.---...--IIAMGAVLTVVLIIICLA........PCLIRSIVKEFL.H.M..RVLIHKNMLQHQ--hlmellkn............................
H0VXU3_CAVPO/388-526                ....VSGIALQT.SL.......QEKHVVELW...HKNSHELWLTQWQI.......NAKLQQQIDLLKQTVEWMGRKILALQHQVFLK...CDWNSTTFYITQRPY.NQTK..hKWE.VIKIYLNG---NT.......SAQEEIESLHNQIDKDFAKQNDDE...S----LAQFAQLLAQSL----....-----.---...--------------------........------------.-.-..--------------kgld................................
W5QF72_SHEEP/399-595                ....TASVSLAQ.SI.......QAAHTVDSL...SYNVTKVMGTQEDI.......DKKIEDRLSALYDVVRVLGEQVQSINFRMKIQ...CHANYKWICVTKKPY.NTSD..fPWD.KVKKHLQGIWFNT.......TVSLDLLQLHNEILDIENSPKATL...NIADTVDNFLQNLFSNFPSLHs..lWRS--.---...--IIAMGAVLTVVLIIICLA........PCLIRSIVKEFL.H.M..RVLIHKNMLQ----prhl................................
W5PBV3_SHEEP/400-602                ....TASVSLAQ.SI.......QAAHTVDSL...SYNVTKVMGTQENI.......DKKIEDRLSALYDVVRVLGEQVQSINFRMKIQ...CHANYKWICVTKKPY.NTSD..fPWD.KVKKHLQGIWFNT.......TVSLDLLQLHNEILDIENSPKATL...NIADTVDNFLQNLFSNFPSLHs..lWRS--.---...--IIAMGAVLTVVLIIICLA........PCLIRSIVKEFL.H.M..RVLIHKNMLQHQ--hlmellkn............................
ENK21_HUMAN/485-682                 ....VAGVALHS.FV.......QSVNFVNDW...QKNSTRLWNSQSSI.......DQKLANQINDLRQTVIWMGDRLMSLEHRFQLQ...CDWNTSDFCITPQIY.NESE..hHWD.MVRRHLQG--RED.......NLTLDISKLKEQIFEASKAHLNLV...PGTEAIAGVADGLANLNPV-T....WVKTI.GST...-TIINLI-LILVCLFCLLLV........CRCTQQLRRDSD.H.R.eRAMMTMVVLSKRK-g...................................
G1TXI8_RABIT/42-230                 gaaa---IGMAVsQA.......STLSTLDNI...TKNTAAVLEHQQEM.......DLHLYTGLRMLNQCVDVMQEELDLLGALAGMP...CLLQSMSTCVTPFKA.AECS...HLA.NDSKALGKMINTTw....nrNFTLLLNKLRRDILWLRETSPSGTtiwSSFATLGSWFGKSWNTVKE--....WVVIG.ALF...IMVLLFGSGLLCLLISI---........------------.-.-..--------------ihrhrqtqlvvkq.......................
W5NUA7_SHEEP/138-319                ....VAGLALHQ.GI.......QTADFVREW...HKDAHLLWQQQHDL.......DAQLATDVLNLQHTVSWLGDQVTVLATKSVLK...CDWNSSHLCVTPVPL.NMSE...GWK.KVKRSLVG---HQ.......NLTAEIMELEQTILSTFS---KTL...PDILGS-DILKSLQEGLDNLNp.lgHVS-T.LLT...TSFVNTLLIVALCFI-----........------------.-.-..--------------afivyrrwrkgkqlkeeir.................
M3Z4E0_MUSPF/82-251                 ...a-AAVALTT.LV.......QTAATFNNV...TGMVAEALAMQEQI.......NGHLHAGILIVNQRVDLVQERLDILESIVSIG...CIHNMAGLCITPIAH.NNLSlaaNLSrQLGNMLNGTWTR-.......QFQNLTRQLRAQIISINATKVPIA...S----VSEWLKMVQQSVSFLK...qWAGLG.SLA...ILLVLANV------------........------------.-.-..--------------lmvrwicsl...........................
K7E601_MONDO/457-641                ....TATLALTS.SI.......QNHEFIQEV...VSNSSKLWHTQQSI.......DLAYRDELDSLKDAVFWLGKEVEALHTRITYP...CHYNQTGYCITPLPY.DNVS..yEWQ.LVVQHIKGAWGSH.......NSTLDIIKLQQQINKLDQIVYENE...A-ANIAANWE-ATLSSLDPQN....WFGRA.NLT..sIGTIILFILLAIGLIILC--........------------.-.-..--------------srscknrayirgil......................
POK7_HUMAN/1246-1443                ....VAGVALHS.SV.......QSVNFVNDW...QKNSTRLWNSQSSI.......DQKLANQINDLRQTVIWMGDRLMSLEHRFQLQ...CDWNTSDFCITPQIY.NESE..hHWD.MVRRHLQG--RED.......NLTLDISKLKEQIFEASKAHLNLV...PGTEAIAGVADGLANLNPV-T....WVKTI.GST...-TIINLI-LILVCLFCLLLV........CRCTQQLRRDSD.H.R.eRAMMTMAVLSKRK-g...................................
M3Y078_MUSPF/44-147                 ...a-AAEALAT.VV.......PTAEALNTL...AEGTAAALQTQLQL.......NAHLKAGLLILNQRVDLLQEQVDILEDIMSVD...CLVPYPTLCVTPVKF.SQFN...KAR.NS-----------.......------------------------...---------------------....-----.---...--------------------........------------.-.-..--------------sqqlsqylqgaclti.....................
K7E1I1_MONDO/157-361                ....VSSVSLAQ.SVanvrtleHDAEYLHGL...AQNVTQVLHLQQDI.......NTRVFYALQQISKDVLLLTNQVEILAIKGKLR...CDYRYSAFCLLPVKA.NRSD...AFE.EIRNDLQGLWLKS.......NISEDIQQLNHITDEMDNSLAEDL...R----PEHIADSLYSWIKSGQ...sWLS--.PLA...QMSITILTFILFIVILVILL........PCLFQILLTSLG.K.IgwTLTLHRLLLQNKKG....................................
K7E1W5_MONDO/457-632                ....TATLALTS.SI.......QNHEFIQEV...VSNSSKLWHTQQSI.......DLAYRDELDSLKDAVFWLGKEVEALHTRITYP...CHYNQAGYCITPLPY.DNVS..yEWQ.LVVQHIKGAWGSH.......NSTLDIIKLQQQINKIDQIVYENE...A-ANIAANWE-ATLSSLDPQN....WFGRA.NLTsigTIILFILLAMGLI--IL---........------------.-.-..--------------csrsck..............................
#=GC SS_cons                        ....XXXXXXXX.XX.......XXXXHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSCHH----------HHHHHHHHHHEE--CCSHHHCXXXXX.XX--...XX-.-HHHHHHHHHHXHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH...HHHTCHHHHH-HHHHHGCHHH....HHHHH.HHH...HHHHHHHCHHHHHHHHHHHXXXXXXXXXXXXXXX------.-.-..--------------XXXX................................
#=GC seq_cons                       ....sAulALps.Sl.......QssphVssl...ppNsoclhpoQppI.......Dp+LpsplssLppsVhhlGcpltsLpp+hpLp...CchNhsthClTPh.Y.Npoc..hpWc.hlppaLpG...ps.......shoh-l.pLcppI.chppt.hs.....s....hsthhptlhs.h...p....Wht...........hl.hh.hhhlhhhhl...........................................t...................................
//
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