GenomeNet

Database: Pfam
Entry: GSK-3_bind
LinkDB: GSK-3_bind
Original site: GSK-3_bind 
#=GF ID   GSK-3_bind
#=GF AC   PF05350.8
#=GF DE   Glycogen synthase kinase-3 binding
#=GF AU   Finn RD
#=GF SE   Pfam-B_18811 (release 7.8)
#=GF GA   25.00 25.00;
#=GF TC   25.60 25.40;
#=GF NC   21.80 24.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11738041
#=GF RT   The structure of phosphorylated GSK-3beta complexed with a
#=GF RT   peptide, FRATtide, that inhibits beta-catenin phosphorylation. 
#=GF RA   Bax B, Carter PS, Lewis C, Guy AR, Bridges A, Tanner R, Pettman
#=GF RA   G, Mannix C, Culbert AA, Brown MJ, Smith DG, Reith AD; 
#=GF RL   Structure (Camb) 2001;9:1143-1152.
#=GF DR   INTERPRO; IPR008014;
#=GF DR   SCOP; 1gng; fa;
#=GF CC   Glycogen synthase kinase-3 (GSK-3) sequentially phosphorylates
#=GF CC   four  serine residues on glycogen synthase (GS), in the sequence
#=GF CC    SxxxSxxxSxxx-SxxxS(p), by recognising and phosphorylating the
#=GF CC   first  serine in the sequence motif SxxxS(P) (where S(p)
#=GF CC   represents a  phosphoserine). Interaction of GSK-3 with a
#=GF CC   peptide derived from GSK-3 binding protein (this family)
#=GF CC   prevents GSK-3 interaction with Axin. This interaction thereby
#=GF CC   inhibits the Axin-dependent phosphorylation of  beta-catenin by
#=GF CC   GSK-3 [1]. 
#=GF SQ   126
#=GS B5DGD3_SALSA/3-79        AC B5DGD3.1
#=GS Q53XP8_HUMAN/1-214       AC Q53XP8.1
#=GS E9IBR3_SOLIN/111-165     AC E9IBR3.1
#=GS M0RAH7_RAT/1-97          AC M0RAH7.1
#=GS G3IMA4_CRIGR/1-85        AC G3IMA4.1
#=GS G3T4U3_LOXAF/1-137       AC G3T4U3.1
#=GS FRAT2_HUMAN/1-214        AC O75474.3
#=GS G3X1T2_SARHA/1-98        AC G3X1T2.1
#=GS F7AUX6_MACMU/1-214       AC F7AUX6.1
#=GS W4WLF8_ATTCE/105-160     AC W4WLF8.1
#=GS L8IA94_9CETA/1-91        AC L8IA94.1
#=GS C1BIH5_OSMMO/39-156      AC C1BIH5.1
#=GS X1WLK6_ACYPI/68-126      AC X1WLK6.1
#=GS H0WCQ4_CAVPO/82-120      AC H0WCQ4.1
#=GS W5NP72_LEPOC/3-107       AC W5NP72.1
#=GS B5DGD3_SALSA/105-154     AC B5DGD3.1
#=GS W5PZV0_SHEEP/135-206     AC W5PZV0.1
#=GS G3N174_BOVIN/134-210     AC G3N174.1
#=GS W5LUT2_ASTMX/3-114       AC W5LUT2.1
#=GS H2NB63_PONAB/1-238       AC H2NB63.1
#=GS Q9YI01_DANRE/89-142      AC Q9YI01.1
#=GS G1SBR4_NOMLE/1-213       AC G1SBR4.1
#=GS U3E856_CALJA/1-142       AC U3E856.1
#=GS G3N7F8_GASAC/104-153     AC G3N7F8.1
#=GS C1BFK2_ONCMY/3-102       AC C1BFK2.1
#=GS B5X9J9_SALSA/108-153     AC B5X9J9.1
#=GS G3UMP2_LOXAF/3-137       AC G3UMP2.1
#=GS M1ER58_MUSPF/1-71        AC M1ER58.1
#=GS G1SPD8_RABIT/5-219       AC G1SPD8.1
#=GS G5C0A7_HETGA/1-43        AC G5C0A7.1
#=GS G3SG99_GORGO/35-104      AC G3SG99.1
#=GS Q4S8R4_TETNG/21-76       AC Q4S8R4.1
#=GS H0XS45_OTOGA/1-135       AC H0XS45.1
#=GS G3N174_BOVIN/1-137       AC G3N174.1
#=GS H2Q2C6_PANTR/1-214       AC H2Q2C6.1
#=GS G1KZR6_AILME/3-145       AC G1KZR6.1
#=GS E1BNA0_BOVIN/1-234       AC E1BNA0.2
#=GS B5XAM6_SALSA/106-151     AC B5XAM6.1
#=GS B2RU64_MOUSE/1-233       AC B2RU64.1
#=GS H2RXZ5_TAKRU/94-160      AC H2RXZ5.1
#=GS U3E856_CALJA/137-214     AC U3E856.1
#=GS M3Z030_MUSPF/1-74        AC M3Z030.1
#=GS Q9YI01_DANRE/3-59        AC Q9YI01.1
#=GS C1BY60_ESOLU/3-97        AC C1BY60.1
#=GS B5THN9_SACKO/52-120      AC B5THN9.1
#=GS H0WCQ4_CAVPO/115-193     AC H0WCQ4.1
#=GS G1KZR5_AILME/1-108       AC G1KZR5.1
#=GS G3X1T2_SARHA/104-156     AC G3X1T2.1
#=GS G3SG99_GORGO/101-159     AC G3SG99.1
#=GS G3TNU2_LOXAF/97-173      AC G3TNU2.1
#=GS W5NP72_LEPOC/113-167     AC W5NP72.1
#=GS E2ACG4_CAMFO/90-148      AC E2ACG4.1
#=GS U3C8J1_CALJA/1-142       AC U3C8J1.1
#=GS C1BIH5_OSMMO/3-71        AC C1BIH5.1
#=GS B7PEY3_IXOSC/74-132      AC B7PEY3.1
#=GS M0R5Z2_RAT/137-210       AC M0R5Z2.1
#=GS U3D5A2_CALJA/1-239       AC U3D5A2.1
#=GS FRAT2_MOUSE/1-140        AC Q8K025.1
#=GS I3MDQ9_SPETR/1-236       AC I3MDQ9.1
#=GS H0XS45_OTOGA/132-207     AC H0XS45.1
#=GS U3FSZ5_CALJA/1-239       AC U3FSZ5.1
#=GS C1BY60_ESOLU/110-155     AC C1BY60.1
#=GS H0WCQ4_CAVPO/1-87        AC H0WCQ4.1
#=GS M0R5Z2_RAT/1-140         AC M0R5Z2.1
#=GS U3DSE3_CALJA/1-142       AC U3DSE3.1
#=GS W5LUT2_ASTMX/120-170     AC W5LUT2.1
#=GS FRAT1_MOUSE/1-233        AC P70339.2
#=GS D3DR49_HUMAN/1-165       AC D3DR49.1
#=GS G3INT0_CRIGR/1-111       AC G3INT0.1
#=GS M3Z030_MUSPF/98-172      AC M3Z030.1
#=GS GBP_XENLA/3-88           AC O93343.1
#=GS U3DSE3_CALJA/137-214     AC U3DSE3.1
#=GS A0A023G792_9ACAR/94-159  AC A0A023G792.1
#=GS G5C0A7_HETGA/42-92       AC G5C0A7.1
#=GS A0A023FRF6_9ACAR/76-139  AC A0A023FRF6.1
#=GS FRAT2_MOUSE/138-211      AC Q8K025.1
#=GS U3CL53_CALJA/1-142       AC U3CL53.1
#=GS U3CL53_CALJA/137-214     AC U3CL53.1
#=GS G1QDF2_MYOLU/86-140      AC G1QDF2.1
#=GS C1BFK2_ONCMY/109-153     AC C1BFK2.1
#=GS U3C8J1_CALJA/137-214     AC U3C8J1.1
#=GS G1QDF2_MYOLU/1-93        AC G1QDF2.1
#=GS M1EMW5_MUSPF/1-35        AC M1EMW5.1
#=GS G3X1Y7_SARHA/47-175      AC G3X1Y7.1
#=GS M3VZ07_FELCA/1-171       AC M3VZ07.1
#=GS B5DGG9_SALSA/3-74        AC B5DGG9.1
#=GS F7GHD6_CALJA/137-214     AC F7GHD6.1
#=GS D3Z8R0_RAT/1-233         AC D3Z8R0.1
#=GS W5PZV0_SHEEP/1-138       AC W5PZV0.1
#=GS L5JPM8_PTEAL/1-75        AC L5JPM8.1
#=GS Q9WVA7_MOUSE/1-232       AC Q9WVA7.1
#=GS B5X9A1_SALSA/3-75        AC B5X9A1.1
#=GS D2H5L3_AILME/37-178      AC D2H5L3.1
#=GS G3IHX4_CRIGR/1-104       AC G3IHX4.1
#=GS F7GHD6_CALJA/1-142       AC F7GHD6.1
#=GS H2RCJ8_PANTR/1-239       AC H2RCJ8.1
#=GS L9JG72_TUPCH/1-92        AC L9JG72.1
#=GS B5XAM6_SALSA/3-74        AC B5XAM6.1
#=GS U3D3I4_CALJA/1-239       AC U3D3I4.1
#=GS GBP_XENLA/60-151         AC O93343.1
#=GS C3YD04_BRAFL/712-771     AC C3YD04.1
#=GS H3D2N6_TETNG/3-103       AC H3D2N6.1
#=GS B5X9J9_SALSA/3-101       AC B5X9J9.1
#=GS W5J9T1_ANODA/29-106      AC W5J9T1.1
#=GS B5X9A1_SALSA/106-154     AC B5X9A1.1
#=GS F7H1S2_MACMU/140-197     AC F7H1S2.1
#=GS G3MI31_9ACAR/97-156      AC G3MI31.1
#=GS A0A023EHW1_AEDAL/66-148  AC A0A023EHW1.1
#=GS U3AXA0_CALJA/1-239       AC U3AXA0.1
#=GS G3UMP2_LOXAF/135-193     AC G3UMP2.1
#=GS U3CTE2_CALJA/1-239       AC U3CTE2.1
#=GS FRAT1_HUMAN/1-239        AC Q92837.3
#=GS FRAT1_HUMAN/1-239        DR PDB; 1GNG Y; 198-223;
#=GS FRAT1_HUMAN/1-239        DR PDB; 3ZRM X; 199-221;
#=GS FRAT1_HUMAN/1-239        DR PDB; 3ZRK Y; 201-222;
#=GS FRAT1_HUMAN/1-239        DR PDB; 4AFJ Y; 200-222;
#=GS FRAT1_HUMAN/1-239        DR PDB; 1GNG X; 198-223;
#=GS FRAT1_HUMAN/1-239        DR PDB; 3ZRL Y; 201-223;
#=GS FRAT1_HUMAN/1-239        DR PDB; 3ZRM Y; 201-222;
#=GS FRAT1_HUMAN/1-239        DR PDB; 3ZRK X; 199-222;
#=GS FRAT1_HUMAN/1-239        DR PDB; 4AFJ X; 200-222;
#=GS FRAT1_HUMAN/1-239        DR PDB; 3ZRL X; 199-221;
#=GS L5JPM8_PTEAL/71-173      AC L5JPM8.1
#=GS H3D2N6_TETNG/106-156     AC H3D2N6.1
#=GS G3TNU2_LOXAF/1-99        AC G3TNU2.1
#=GS B5DGG9_SALSA/106-152     AC B5DGG9.1
#=GS G3SG99_GORGO/1-40        AC G3SG99.1
#=GS B7U5G4_HALDI/67-136      AC B7U5G4.1
#=GS F7H1S2_MACMU/1-142       AC F7H1S2.1
#=GS H0Y0G4_OTOGA/1-237       AC H0Y0G4.1
#=GS V4ACG1_LOTGI/20-125      AC V4ACG1.1
#=GS U3BF68_CALJA/1-239       AC U3BF68.1
#=GS E0VMG3_PEDHC/85-147      AC E0VMG3.1
#=GS G3INT8_CRIGR/1-235       AC G3INT8.1
#=GS M3Z030_MUSPF/72-99       AC M3Z030.1
#=GS G3IMA4_CRIGR/83-116      AC G3IMA4.1
B5DGD3_SALSA/3-79                   .........................................cr--------.--.......--------..-..-.-KE..NYILLEQSVTVD......S-KEVDALVTKIGEALQLHNN....ST.NQKTMCL-----------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------hgltsncsssnitkqannnngvalqkrtgcci..............................
Q53XP8_HUMAN/1-214                  ...........................................MPCRREEE.EE.......AGEEAEGE..E..E.EDD..SFLLLQQSVTLG......SSGEVDRLVAQIGETLQLDAA....QD.SPASPCAPPGVPLRAPGP.L...AAaVPTDKARP.PAVPLLLPPASAETV..GPAPSGALRCALGDRGR.VRGRAAPYCV.AEVAAGPSALP------------------------GPCRRGWLRD..AVTS..RRL.........QQ.........RRWTQAGARAG.D....DDPH..RLLQQL.VLSGNLIKEAVRRLQRAVAAVAATGPASA----pgp...........................................................
E9IBR3_SOLIN/111-165                .................................hhhhhyhlkr--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----SERSRV.D....DDPY..EVLQEL.LREGGLIKEAVKRLQENLDE-------------lssseade......................................................
M0RAH7_RAT/1-97                     ...........................................--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.------------LPXQPGFDGPPGTGKLNTPQPLSGPCRRGWLRN..AAAS..RRL.........PQ.........RRGSQPETRTG.D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLHAKLPAHPFLGP..............................................................
G3IMA4_CRIGR/1-85                   ...........................................MPSQRAEK.-E.......AGFEAEGE..D..K.-DD..SFLLLQQSVTLS......NLTDVDQLIAKIGETLKLDTA....HD.GPASPSAAPGPP--PLRV.L...AA.ISVEQNRS.P--------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------l.............................................................
G3T4U3_LOXAF/1-137                  ..........................................a--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..GPAPPGALYSTFGDCGS.VRDWAEPYLV.AEFAPGPTALSLLPPQPGFEGTPGSGKPGASRQLSGRCRRGWLRG..AAAS..RRL.........RQ.........RLGPRAKGRTS.D....DDSH..RLLQQL.LLSGNLIKEAVRRLRSRRLHLYAKLPQRRLPGP..............................................................
FRAT2_HUMAN/1-214                   ...........................................MPCRREEE.EE.......AGEEAEGE..E..E.EDD..SFLLLQQSVTLG......SSGEVDRLVAQIGETLQLDAA....QD.SPASPCAPPGVPLRAPGP.L...AAaVPADKARP.PAVPLLLPPASAETV..GPAPSGALRCALGDRGR.VRGRAAPYCV.AEVAAGPSALP------------------------GPCRRGWLRD..AVTS..RRL.........QQ.........RRWTQAGARAG.D....DDPH..RLLQQL.VLSGNLIKEAVRRLQRAVAAVAATGPASA----pgp...........................................................
G3X1T2_SARHA/1-98                   ...........................................MPCRREEE.DEddetaasGEDDDEGE..G..E.EEE..SFLVLQQSVTVG......GSGDVDRLVAQIGELLRLDAA....HV.SPAAAGGPVQAHLASRR-.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------rplppsaapapppppp..............................................
F7AUX6_MACMU/1-214                  ...........................................MPCRREEE.EE.......AGEEAEGE..E..E.EED..SFLLLQQSVTLG......SSGEVDRLVAQIGETLQLDAA....QD.SPASPCAPPGAPLRAPGS.L...AAaVPADKARP.PAVPLLLPPASAETV..GPAPPGALRCALGDRGR.VRGRAAPYCV.AELAAGPSALP------------------------GPCRRGWLRD..AVTS..RRL.........QQ.........RRWTQAGARSG.D....DDPH..RLLQQL.VLSGNLIKEAVRRLQRAVAAVAATGPASA----pgp...........................................................
W4WLF8_ATTCE/105-160                ................................hhhhyhnhlkr--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........------SERRV.D....DDPY..EVLQEL.LREGGLIKEAVKRLQENLDEL------------sssevden......................................................
L8IA94_9CETA/1-91                   ...........................................--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.------------------LDGPLGADKRGSPQPLSGPCRRGWLRG..AVTS..RRL.........PQ.........RRWPPAGARAN.D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLHAKLPQRQLLGP..............................................................
C1BIH5_OSMMO/39-156                 ................................sanqktmsclh--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.-----------GLNGSSNVKQPNNNNGAPILQKRTGCCMRLRKRG..QRSS..RASpynipgssdQEwd.....hfKPWNRKRVNVE.E....DDPH..QLLQEL.ILSGNLIKEAVRRLQF-----------------sttecgdhskmte.................................................
X1WLK6_ACYPI/68-126                 ........................trpaacescaarrpcrcdd--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........----DDDDDQA.N....DDPY..EMLQAL.LREGSLIKEAVRRLQ------------------iglspkq.......................................................
H0WCQ4_CAVPO/82-120                 .......................................rlpr--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..----VSAVRCALGDRGR.VRGRTAPYGV.AELAADPGVLP----------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------r.............................................................
W5NP72_LEPOC/3-107                  .........................................cr--------.--.......--------..-..-.-KE..NYILLEQSVTVD......S-KEVDALVTKIGEALQLHSS....AG.ANSQKTLSSC-----LHH.S...HS.SSGDKHTC.TSTKHSYSASHTRTS..SNTKHG---CCIRLRNRgLRSRASPYSI.---------------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------pgd...........................................................
B5DGD3_SALSA/105-154                ................................dnfkrwdrkgi--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........------NAAVE.K....DDPH..QLLQEL.ILSGNLIKEAVRRLQF-----------------sttecvd.......................................................
W5PZV0_SHEEP/135-206                ..........................................t--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------LPGPCRRGWLRG..AVTS..RRL.........QQ.........RRWPPAGARAN.D....DDPH..RLLQQL.VLSGNLIKEAVRRLQRA----------------vpagagtgpra...................................................
G3N174_BOVIN/134-210                .........................................st--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------LPGPCRRGWLRG..AVTS..RRL.........PQ.........RRWPPAGARAN.D....DDPH..RLLQQL.VLSGNLIKEAVRRLQRAVAAVAATGPAG-----pagp..........................................................
W5LUT2_ASTMX/3-114                  .........................................cr--------.--.......--------..-..-.-KE..NYIFLEQSVTVD......S-KEVDALVTKIGEALQLHNN....SA.GQTMSCL-HGLGSSSSGG.G...GS.SSSSSSSS.GGGGHGSRQSTGTAG..NPRRGG---CCIRLRSRnLRSRASPYNI.---------------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------pgssdq........................................................
H2NB63_PONAB/1-238                  ...........................................MPCRREEE.EE.......AGEEAEGE..E..E.EED..SFLLLQQSVPLG......SSGEVDRLVAQIGETLQLDAA....QH.SPASPCGPPGAPLRAPGP.L...AA.AVXXXXWTrRSTARPRVRALAETV..GPAPPG-LRCALGDRGR.VRGRAAPYCV.AELATGPSALSPLPPQADLDGPPGAGKQGIPQPLSGPCRRGWLRG..AAAS..RRL.........QQ.........RRGSQPETRTG.D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLGP..............................................................
Q9YI01_DANRE/89-142                 ..............................gssdqewdhfkss--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........----WNRKKID.E....DDPH..QLLQEL.ILSGNLIKEAVRRLQ------------------fssepsdh......................................................
G1SBR4_NOMLE/1-213                  ...........................................MPCRREEE.EE.......AGEEAEGE..E..E.-ED..SFLLLQQSVTLG......SSGEVDRLVAQIGETLQLDAA....QD.SPASPCAPPGAPLRAPGP.L...AAaVQADKARP.PAVPLLLPPASAETV..GPAPSGALRCALGDRGR.VRGRAAPYCV.AEFAAGPSALP------------------------GPCRRGWLRD..AVTS..RRL.........QQ.........RRWTPAGARAG.D....DDPH..RLLQQL.VLSGNLIKEAVRRLQRAVAAVAATGPASA----pgp...........................................................
U3E856_CALJA/1-142                  ...........................................MPCRREEE.EE.......AGEEAEGE..E..E.EED..SFLLLEQSVALG......GSGEVDRLVAQIGETLQLDPA....QD.SPASPCAPPRAPLRAPGP.L...AAaVPADKARP.LAVPLLLPSASAETV..GPAPHGALRCALGDRGR.VRGRAAPYCV.AELAAGPSTLP----------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------g.............................................................
G3N7F8_GASAC/104-153                ......................................drdwd--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........QI.........KPWHKKRIEAE.E....DDPH..RLLQEL.ILSGNLIKEAVRRLQF-----------------saaec.........................................................
C1BFK2_ONCMY/3-102                  .........................................cr--------.--.......--------..-..-.-KE..NYILLEQSVTVD......S-KEVDALVTKIGEALQLHNN....SA.NQKTMS------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------clhglngncsssnikqannnnngvaqqkrtgccirlrnrgqrsnraspysfpgssn......
B5X9J9_SALSA/108-153                ..................................kpwnrkris--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-------AAVE.N....DDPH..QLLKEL.ILSGNLIKEAVRRLQF-----------------sttecg........................................................
G3UMP2_LOXAF/3-137                  ..........................grqrrpqssgcpgrgpc--------.--.......--------..-..-.RAD..SFLLLEQPARLG......GSAEVDRLVAQIGEALQLDPA....QD.SPASLCAPPWQPLQPPLP.L...AE.VPAYRARP.PALPLHLPPSSVEAT..N---LGALYSTFGDCGS.VRDWAEPYLV.AEFAPGPTAL-----------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------ls............................................................
M1ER58_MUSPF/1-71                   ...........................................---RREEE.EE.......AGEEAEGEaeE..E.EED..SFLLLEQSVTLGgwvtrgGSGEVDLLVAQIGETLQLDAA....QD.SPASPCAP----------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------..............................................................
G1SPD8_RABIT/5-219                  ..........................................r-PQKRKRC.EQ.......ARGRAE--..-..-.RRT..SFLLLEQSVTLG......GSGEVDRLVAQIGETLQLDAA....QD.SPASPCAPPGRHSSSPRG.L...GA.VRADKAWS.PGVPLLRRLSLAEAV..DGSP-GAVRCALGDRAP.LLRRSAPYCL.VRAGRG------------------FGKQGIPQPLSGPCRRGWLRG..AASS..RRL.........QQ.........RRGSQPETRTS.D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLRPKLPPCQLPGP..............................................................
G5C0A7_HETGA/1-43                   ...........................................MPCRREEE.EE.......AGEEAEGE..E..E.-EG..SFLLLEQSVTLG......GSGEVDRL-------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------p.............................................................
G3SG99_GORGO/35-104                 ........................................qhl--------.--.......--------..-..-.---..------------......---------------------....--.------------------.A...AA.VPADKARS.PAVPLLLPPASAETV..GPAPPGVLRCALGDRGR.LRGRAAPYCV.AELATGPSALSPLS-------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------..............................................................
Q4S8R4_TETNG/21-76                  ..................................gsdgdrdwd--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........QI.........RQWKRKAMAVE.E....DDPH..RLLQEL.ILSGNLIKEAVRRLQL-----------------saadcge.......................................................
H0XS45_OTOGA/1-135                  ...........................................MPCGREEE.EE.......AGEEAE-E..E..-.-ED..SFLLLEQSVTLG......SSGEVDRLVAQIGETLQLDAA....QD.SPASPCAPPGAPLRPP--.-...AA.VPADKAWA.PAVPLLWPPASAEVV..GPALPGTLRCALGDRGR.VRGRAAPYCV.AELAAGPSALP----------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------g.............................................................
G3N174_BOVIN/1-137                  ...........................................MPCRREEE.EE.......AGEEEE--..-..E.EED..SILLLEQSVTVG......GSVEVDRLVAQIGETLQLDAA....QD.RPASACAPPGPPLQPPRP.P...AA.VRADKARA.PAQPLLLPAVSVEAG..GPAPSGALRCALGDRGR.VRGRAAPYFV.AELATGASTLP----------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------..............................................................
H2Q2C6_PANTR/1-214                  ...........................................MPCRREEE.EE.......AGEEAEGE..E..E.EED..SFLLLQQSVTLG......SSGEVDRLVAQIGETLQLDAA....QH.SPASPCAPPGVPLRAPGP.L...AAaVPADKARP.PAVPLLLPPASAETV..GPAPSGALRCALGDRGR.VRGRAAPYCV.AEVAAGPSALP------------------------GPCRRGWLRD..AVTS..RRL.........QQ.........RRWTQAGARAG.D....DDPH..RLLQQL.VLSGNLIKEAVRRLQRAVAAVAATGPASA----pgp...........................................................
G1KZR6_AILME/3-145                  .......................................lftn------QP.EE.......AGEEAEGEaeE..E.EED..SFLLLEQSVTLG......GSGEVDLLVAQIGETLQLDAA....QD.SPASPCAPPGPPAAGRRR.LpppAT.APRAPARI.PHRRRRPAPAPAAAGalGEPHQGGRAEASFETAA.VTRKASPTPA.LRASVGPSA------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------..............................................................
E1BNA0_BOVIN/1-234                  ...........................................MPCRREEE.EE.......AGEEEE--..-..-.EED..SFLLLEQSVTVG......GSVEVDRLVAQIGETLQLDAA....QD.RPASACAPPGPPLQPPRS.P...AA.VRADKARA.PAQPLLLPAASIEAG..GPAPLGALRCALGDRGR.VRGRAAPYFV.AELAAGPTALSPLPPQPSLDGPLGADKRGSPQPLSGPCRRGWLRD..AAAS..RRL.........QH.........RRGLQPPARNG.D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLHAKLPQRQLLGP..............................................................
B5XAM6_SALSA/106-151                .................................fkpwnrkris--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-------AAVE.N....DDPH..QLLQEL.ILSGNLIKEAVRRLQ------------------fsttgc........................................................
B2RU64_MOUSE/1-233                  ...........................................MPCRREEE.EE.......AGDEAEGE..E..D.-DD..SFLLLQQSVTLG......GSTDVDQLIVQIGETLQLDAA....HD.RPASPCAAPGPP--PPQV.L...AA.LPADKTGT.PARRLLRPTGSAETG..NPAPPGAVRCVLGERGR.VRGRSAPYCV.AEISPGASAL---PQQPGLDGPPGTGKLSTPQPLSGPCRRGWLRN..AAAS..RRL.........QQ.........RRGSQPETRTGdD....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRQLQLHAKLPAHPFLGP..............................................................
H2RXZ5_TAKRU/94-160                 ..................rraspynipgssgeqdwdrikqwng--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----KTMAAE.E....EDPH..RLLQEL.ILSGNLIKEAVRRLQF-----------------saadcaefp.....................................................
U3E856_CALJA/137-214                ...........................................--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.------------------------------PSTLPGPCRRGWLRD..AVTS..RRL.........QQ.........RRWTQAGARAG.D....DDPH..RLLQQL.VLSGNLIKEAVRRLQRAVAAVAATSPASA----agp...........................................................
M3Z030_MUSPF/1-74                   ...........................................MPCRREEE.EE.......AGEEAEGEaeE..E.EED..SFLLLEQSVTLG......GSGEVDLLVAQIGETLQLDAA....QD.SPASPCAPPGPPL-----.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------g.............................................................
Q9YI01_DANRE/3-59                   .........................................cr--------.--.......--------..-..-.-KE..NYIFLEQSVTVD......S-KEVDALVSKIGEALQLHNN....SS.SQKA--------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------msrlhgftgskpngg...............................................
C1BY60_ESOLU/3-97                   .........................................cr--------.--.......--------..-..-.-KE..NYILLEQSVTVD......S-KEVDALVTKIGEALQLHNN....NS.A-----------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------nqktmsclhgltsngsssnvkqathnngvalqkrtgccmrlrnmgqrsnraspysf......
B5THN9_SACKO/52-120                 ....................................yhspckh--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.-------------------------------------CRTGQVCH..SKDC..SYL.........RH.........THSKRIKKKTG.D....NDAH..KLLEQL.LRQGNLIKEAVGRLNF-----------------ksepkck.......................................................
H0WCQ4_CAVPO/115-193                ........................................pgv--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------LPRPCRREWLQG..SVAS..RRL.........QQ.........RRWTHAAARAGsD....DDPH..RLLQQL.VLSGNLIKEAVRRLQRAVAAVAATSP-------vgtpgp........................................................
G1KZR5_AILME/1-108                  ...........................................--------.-E.......AGEEAEGEaeE..E.EED..SFLLLEQSVTLG......GSGEVDLLVAQIGETLQLDAA....QD.SPASPCAPPGPPAAAPGHtK...SA.SKMLYGKP.QLARMDLPPSSATTR..-----------------.----------.---------------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------lffpgglcsign..................................................
G3X1T2_SARHA/104-156                .......................................aphr--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........---GQPGLRAG.G....NDSH..RLLQQL.LLSGDLIKEAVRRLQRAVAAVT-----------gagssatp......................................................
G3SG99_GORGO/101-159                ..........................................s--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.--------------------------------PLSGPCRRGWLRG..AAAS..RRL.........QQ.........RRGSQPETRTG.D....DDPH..RLLQQL.VLSGNLIKEAVRRL-------------------..............................................................
G3TNU2_LOXAF/97-173                 ..........................................a--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------LPGPCRRGWLRG..AATA..NRL.........QQ.........RRWPQAGTRAG.N....DGSHddRLLQQL.VLSGNLIKEAVRRLQRAVAAA------------aavagglsgp....................................................
W5NP72_LEPOC/113-167                .................................wdslrawnrk--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........----KIDVSSQ.E....DDPH..QLLQEL.ILSGNLIKEAVRRLQLS----------------tadradlckp....................................................
E2ACG4_CAMFO/90-148                 ..........................qnhvtaghhhhyhshlk--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........----RTERNRV.D....DDPY..EVLQEL.LREGGLIKEAVKRLQAN----------------ldefsss.......................................................
U3C8J1_CALJA/1-142                  ...........................................MPCRREEE.EE.......AIEEAEGE..E..E.EED..SFLLLEQSVTLG......SSGEVDRLVAQIGETLQLDPA....QD.SPASPCAPPRAPLRAPGP.L...AAaVPADKARP.LAVPLLLPSASAETV..GPAPHGALRCALGDRGR.VRGRAAPYCV.AELAAGPSTLP----------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------g.............................................................
C1BIH5_OSMMO/3-71                   .........................................cr--------.--.......--------..-..-.-KE..NYILLEQSVTVD......S-KEVDALVTKIGEALQLHNN....SA.N-----------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------qktmsclhglngssnvkqpnnnngapilqk................................
B7PEY3_IXOSC/74-132                 ..................................vsavpkdvv--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........RRTCANHHQDA.D....KDPY..EMLQDL.LRQGTLIQEAVRRLQENVV--------------gktkaphsl.....................................................
M0R5Z2_RAT/137-210                  .........................................lp--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.-----------------------------------RPGRRGWLPG..ALAS..RRI.........QQ.........RRCTASGSRAA.D....DDPH..RLLQQL.VLSGNLIKEAVRRLQRAVAAVAATSPAS-----apg...........................................................
U3D5A2_CALJA/1-239                  ...........................................MPCRREEE.EE.......AIEEAEGE..E..E.EED..SFLLLEQSVTLG......SSGEVDRLVAQIGETLQLDAA....QD.SPASPCAPPRAPLRAPGP.L...AAaVPADKARP.LAVPLLLPSASAETV..GPAPHGALRCALGDRGR.VRGRAAPYCV.AELAAGPSALSPLPPQADLDGPPGAGKQGVPQPLSGPCRRGWLRG..AAAS..RRL.........QQ.........RRGSQPETRTG.D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLGP..............................................................
FRAT2_MOUSE/1-140                   ...........................................MPCRREEE.EE.......AGDEAEGE..E..D.-DD..SFLLLQQSVTLG......GSTDVDRLIVQIGETLQLDTA....HD.RPASPCAAPGPPPAPPRV.L...AA.LSADKTGT.PARRLLRPTGSAETG..DPAPPGAVRCVLGERGR.VRGRSAPYCV.AEIAPGASALP----------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------g.............................................................
I3MDQ9_SPETR/1-236                  ...........................................MPCRREEE.EE.......AGEEAEGE..E..EdDDD..SFLLLKQSVTLE......GSGEVDRLVAQIGQTLQLDAA....HD.SPASRCVPPGPPLQPP--.-...VA.LPADKARS.PAVPLLLRPVSAEAG..GLAPPGALRCALGDRGR.VRGRAAPYCV.AELSSGPSALSPLSSQPGLDGPPGAGKQGIPQPLTGPCRRGWLRS..AAAS..RRL.........QQ.........RRGSQPDTCTG.D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLHAKLPQHRLLGP..............................................................
H0XS45_OTOGA/132-207                ..........................................a--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------LPGPCRRGWLRG..AVAS..RRL.........PQ.........RRWTQTGAHAG.D....DDPH..RLLQQL.VVSGNLIKEAVRRLQRAVAAVAATGPV------gtpgp.........................................................
U3FSZ5_CALJA/1-239                  ...........................................MPCRREEE.EE.......AGEEAEGE..E..E.EED..SFLLLEQSVALG......GSGEVDRLVAQIGETLQLDPA....QD.SPASPCAPPGAPLRAPGP.L...AAaVRADKARP.PAVPLLLPPVSMETV..GPAPLGALRSTLGDRGR.VRGRAAPYCV.AELAAGPSALSPLPPQADLDGPPGAGKQGVPQPLSGPCRRGWLRG..AAAS..RRL.........QQ.........RRGSQPETRTG.D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLGP..............................................................
C1BY60_ESOLU/110-155                ...................................pwnrkiin--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-------AAVE.N....DDPH..QLLQEL.ILSGNLIKEAVRRSQ------------------fstaecge......................................................
H0WCQ4_CAVPO/1-87                   ..........................................q----RAGK.EE.......EDREVQGW..SrvE.EDQ..SFLLLEQTVTLG......GSGEVDRLG----GPDRQDAAvwtrHPtARPSPGAPPGPPLQPPRP.P...AA.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------slrlprvs......................................................
M0R5Z2_RAT/1-140                    ...........................................MPCRREEEeEE.......AGDEAEGE..E..D.-DD..SFLLLQQSVTLG......GSTDVDRLIAQIGETLQLDAA....HD.SPASPCAAPGPPP-APPV.L...AA.LPADKVGG.PAR-LLRPAASAEAG..DPAPPGAVRCVLGERGR.VRGRAAPYCV.AEIAPGASALP----------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------rp............................................................
U3DSE3_CALJA/1-142                  ...........................................MPCRREEE.EE.......AIEEAEGE..E..E.EED..SFLLLEQSVTLG......GSGEVDRLVAQIGETLQLDAA....QD.SPASPCAPPRAPLRAPGP.L...AAaVPADKARP.LAVPLLLPSASAETV..GPAPHGALRCALGDRGR.VRGRAAPYCV.AELAAGPSTLP----------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------g.............................................................
W5LUT2_ASTMX/120-170                .......................................ktwn--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-RGKGLDVTGS.E....DDPH..QLLQEL.ILSGNLIKEAVRRLQY-----------------sadsehdlak....................................................
FRAT1_MOUSE/1-233                   ...........................................MPCRREEE.EE.......AGDEAEGE..E..D.-DD..SFLLLQQSVTLG......GSTDVDQLIVQIGETLQLDAA....HD.RPASPCAAPGPP--PPQV.L...AA.LPADKTGT.PARRLLRPTGSAETG..NPAPPGAVRCVLGERGR.VRGRSAPYCV.AEISPGASAL---PQQPGLDGPPGTGKLSTPQPLSGPCRRGWLRN..AAAS..RRL.........QQ.........RRGSQPETRTGdD....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRQLQLHAKLPAHPFLGP..............................................................
D3DR49_HUMAN/1-165                  ...........................................MPCRREEE.EE.......AGEEAEGE..E..E.EED..SFLLLQQSVALG......SSGEVDRLVAQIGETLQLDAA....QH.SPASPCGPPGAPLRAPGP.L...AAaVPADKARS.PAVPLLLPPALAETV..GPAPPGVLPCALGDRGR.VRGRAAPYWRwPRLQQAPGRCPHCPLRPTLMG------------------------..----..---.........--.........-----------.-....----..------.---------------------------------lrelasrasrsrc.................................................
G3INT0_CRIGR/1-111                  ...........................................--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..----------MLWEPRR.LQSRAAPYCM.VELTPDASALCPVSQQPGLEGPPVTGKPSTLQPLSGPCWRGWPQS..TAMS..RLL.........QQ.........RCGSQPDTHTS.D....EDPH..QLLQQL.LLSGNLIKEAVQ---------------------apivlv........................................................
M3Z030_MUSPF/98-172                 ...........................................--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------LPGPCRRGWLRG..AASS..RRL.........QQ.........RRWPPAGTRAR.D....DDPH..RLLQQL.VLSGNLIKEAVRRLQRAVAAVAATSPA------gasgp.........................................................
GBP_XENLA/3-88                      .........................................cr--------.--.......--------..-..-.-KE..SFLLLEQSVTVG......-SGEVDTLVARIGEALQLN-A....QR.TPTSCSMAYGALKPVSRA.G...PS.CSCVRG--.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------rstpypvctprgaarhaqhhhh........................................
U3DSE3_CALJA/137-214                ...........................................--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.------------------------------PSTLPGPCRRGWLRD..AVTS..RRL.........QQ.........RRWTQAGARAG.D....DDPH..RLLQQL.VLSGNLIKEAVRRLQRAVAAVAATSPASA----agp...........................................................
A0A023G792_9ACAR/94-159             .........................ssgvlsavakdcarrtca--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........--ASHQHQQDS.D....KDPY..ELLQEL.LQQGTLIQEAVRRLQDNVV--------------gkkktphsl.....................................................
G5C0A7_HETGA/42-92                  ..........................................l--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----PEPRAG.D....DDPH..RLLQQL.VLSGNLIKEAVRRLHARRLQLQAKLPQGPLLGP..............................................................
A0A023FRF6_9ACAR/76-139             ...........................gvlsavakdcarrtca--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........--ASHQHQQDS.D....KDPY..ELLQEL.LQQGTLIQEAVRRLQDNVV--------------gkkktphsl.....................................................
FRAT2_MOUSE/138-211                 ...........................................--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------LPGPGRRGWLPG..SVAS..HRI.........QQ.........RRWTAGGARAA.D....DDPH..RLLQQL.VLSGNLIKEAVRRLQRAVAAVAATSPAS-----apg...........................................................
U3CL53_CALJA/1-142                  ...........................................MPCRREEE.EE.......AIEEAEGE..E..E.EED..SFLLLEQSVTLG......SSGEVDRLVAQIGETLQLDPA....QD.SPASPCAPPGAPLRAPGP.L...AAaVRADKARP.PAVPLLLPPVSMETV..GPAPLGALRSTLGDRGR.VRGRAAPYCV.AELAAGPSTLP----------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------g.............................................................
U3CL53_CALJA/137-214                ...........................................--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.------------------------------PSTLPGPCRRGWLRD..AVTS..RRL.........QQ.........RRWTQAGARAG.D....DDPH..RLLQQL.VLSGNLIKEAVRRLQRAVAAVAATSPASA----agp...........................................................
G1QDF2_MYOLU/86-140                 .......................................karp--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----PDXRTG.D....DDPH..RLLQQLgALPGTSSRKACGGFHSRRLQLHAKLPQRPLLRP..............................................................
C1BFK2_ONCMY/109-153                ..................................kpwnrkris--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-------AAVE.N....DDPH..QLLQEL.ILSGNLIKEAVRRLQF-----------------sttec.........................................................
U3C8J1_CALJA/137-214                ...........................................--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.------------------------------PSTLPGPCRRGWLRD..AVTS..RRL.........QQ.........RRWTQAGARAG.D....DDPH..RLLQQL.VLSGNLIKEAVRRLQRAVAAVAATSPASA----agp...........................................................
G1QDF2_MYOLU/1-93                   .......................................vpgg----KEEK.GK.......PGRKRRGE..E..R.REDqgNFLLLERSVTLG......GSGEVDRLVAQIGETLQLDAG....QD.SPASLCAPPGPPLQPPRP.P...AA.VLADKARP.PD-------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------xr............................................................
M1EMW5_MUSPF/1-35                   ...........................................--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----------.-....----..----QL.VLSGNLIKEAVRRLHSRRMQLHAKLPQRPLTGP..............................................................
G3X1Y7_SARHA/47-175                 ................vgavaplpsrvqsspcvpggapgrsst--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.--------------------SAPHICKRGLPQPLAGPCRRTWLRG..AAAS..RRL.........QQqhhhqhpqyRYRGQPGLRAG.E....DDPH..QLLQQL.VLSGNLIKEAVRRLHSRRPRL------------ylgaraplpqepsppp..............................................
M3VZ07_FELCA/1-171                  ..........................................g--------.--.......--------..-..-.---..------------......---------------------....--.----------PAATSPIV.Y...KS.TRAGRIPA.PAAAGALPPAPAEAV..GPAPPGALRCALGDRGR.VRGRAAPYFV.AELAAGPSALSPLAPHPGFDGPSGANKRGAPQPLSGPCRRGWLRG..AAAS..RRL.........QQ.........RRGTQLESRTG.D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLHAKLPQRPLTGP..............................................................
B5DGG9_SALSA/3-74                   .........................................cr--------.--.......--------..-..-.-KE..NYILLEQSVTVD......S-KEVDALVTKIGEALQLHNN....SA.N-----------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------qktmsclhgltgncsssnikqannnngvalqkr.............................
F7GHD6_CALJA/137-214                ...........................................--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.------------------------------PSTLPGPCRRGWLRD..AVTS..RRL.........QQ.........RRWTQAGARAG.D....DDPH..RLLQQL.VLSGNLIKEAVRRLQRAVAAVAATSPASA----agp...........................................................
D3Z8R0_RAT/1-233                    ...........................................MPCLREE-.EE.......ASDQADGE..E..D.-ND..SFLLLQQSVTLG......GSADVDQLIARIGETLQLDTA....HD.SPASQCAAPGPPPAPPRV.L...AA.LPADKARA.PTRRLLRLAASPETW..DPAPPGAMRCVLGERGR.VRDRAAPYSV.AEIAPGPSVL---PQQQGLEGPQGTGKLSIPQPLSGPCRRGWLRN..TAAS..RRL.........QQ.........RRGSHLETRTG.E....DDPP..RLLQQL.LLSGNLIKEAVRRLHSRRLQLQAKLPAHPFLEP..............................................................
W5PZV0_SHEEP/1-138                  ...........................................MPCRREEE.EE.......AGEEEE--..-..E.EED..SFLLLEQSVTVG......GSVEVDRLVAQIGETLQLDAA....QD.RPASACAPPGPPLQPPRP.P...AA.VRADKARA.PAQPLLLPAASVEAG..GPAPPGALRCALGDRGR.VRGRAAPYFV.AELAAGASTLP----------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------g.............................................................
L5JPM8_PTEAL/1-75                   ...........................................MPCRREEE.EE.......AGEEAEGE..E..E.EED..SFFLLEQSVTLG......SSGEVDRLVAQISETLQLDGA....QD.SPASPCAPSGPPLHAL--.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------s.............................................................
Q9WVA7_MOUSE/1-232                  ...........................................MPCRRE--.EE.......AGDEAEGE..E..D.-DN..SFLLLQQSVTLG......GSADVDRLIAQIGETLQLDAR....HD.GPASPCAAPGPPPAPPRV.L...AA.LPADKAGA.PARRLLRRAASAEAG..DPAPPGAVRCVLGERGR.LRGRAAPYCV.AEIAPGASAL---PQQLGLEVSPGMGKVSIPQPLSGRCRRGWLRN..AAAS..RRQ.........QQ.........RRGSQSETRTS.D....GDPP..RLLQQL.LLSGNLIKEAVRRLHSRGLQLQAKLPAHSFLGP..............................................................
B5X9A1_SALSA/3-75                   .........................................cr--------.--.......--------..-..-.-KE..NYILLEQSVTVD......S-KEVDALVTKIGEALQLHNN....ST.NQKTMC------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------lhgltsncsssnitkqannnngvalqkrt.................................
D2H5L3_AILME/37-178                 .....................................snkgtg--------.-R.......AGEEAEGEaeE..E.EED..SFLLLEQSVTLG......GSGEVDLLVAQIGETLQLDAA....QD.SPASPCAPPGPPAAGRRR.LpppAT.APRAPARI.PHRRRRPAPAPAAAGalGEPHQGGRAEASFETAA.VTRKASPTPA.LRASVGPSA------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------..............................................................
G3IHX4_CRIGR/1-104                  ...........................................MPCQSAEK.-E.......AGFETEGE..D..K.-DD..SFLLLQQSVTLG......SLTDVDQLIAKIGETLKQIFC....VC.RDRGPSSPWSHSLH----.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------avrtgacgagqlptvwqssprapasyplcpcsla............................
F7GHD6_CALJA/1-142                  ...........................................MPCRREEE.EE.......AIEEAEGE..E..E.EED..SFLLLEQSVTLG......SSGEVDRLVAQIGETLQLDAA....QD.SPASPCAPPRAPLRAPGP.L...AAaVPADKARP.LAVPLLLPSASAETV..GPAPHGALRCALGDRGR.VRGRAAPYCV.AELAAGPSTLP----------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------g.............................................................
H2RCJ8_PANTR/1-239                  ...........................................MPCRREEE.EE.......AGEEAEGE..E..E.EED..SFLLLQQSVALG......SSGEVDRLVAQIGETLQLDAA....QH.SPASPCGPPGALLRAPGP.L...AAaVPADKARS.PAVPLLLPPASAETV..GPAPPGVLRCALGDRGR.VRGRAAPYCV.AELATGPGALSPLPPQADLDGPPGAGKQGIPQPLSGPCRRGWLRG..AAAS..RRL.........QQ.........RRGSQPETRTG.D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLGP..............................................................
L9JG72_TUPCH/1-92                   ...........................................MPCRREEEeEE.......AGEEAEGE..E..EvEED..SFLLLEQAVTLG......GSGEVDRL-ALIT--------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------qchpadslmekeemslglaeagcgcprkavsrlqrlrvhldaw...................
B5XAM6_SALSA/3-74                   .........................................cr--------.--.......--------..-..-.-KE..NYILLEQSVTVD......S-KEVDALVTKIGEALQLHNN....SA.N-----------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------qktmsclhgltgncsssnikqannnngvalqkr.............................
U3D3I4_CALJA/1-239                  ...........................................MPCRREEE.EE.......AIEEAEGE..E..E.EED..SFLLLEQSVTLG......SSGEVDRLVAQIGETLQLDPA....QD.SPASPCAPPGAPLRAPGP.L...AAaVRADKARP.PAVPLLLPPVSMETV..GPAPLGALRSTLGDRGR.VRGRAAPYCV.AELAAGPSALSPLPPQADLDGPPGAGKQGVPQPLSGPCRRGWLRG..AAAS..RRL.........QQ.........RRGSQPETRTG.D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLGP..............................................................
GBP_XENLA/60-151                    scscvrgrstpypvctprgaarhaqhhhhhsprqqgtggnkrl--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.-------------------------------------CGRGWGRC..NC--..---.........--.........RKH---AGTEE.E....DDPH..ELLQEL.LLSGNLIKEAVRRLHM-----------------ages..........................................................
C3YD04_BRAFL/712-771                ..........................anksgavckkspprnar--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-RLLQ--RRCD.S....EDPY..AMLQEL.LRSGNLIKEAVKRLGSR----------------getgrtr.......................................................
H3D2N6_TETNG/3-103                  .........................................cr--------.--.......--------..-..-.-KE..NYILLEQSVTVG......S-KEVDALVTRIGEALQLHNN....GG.G-----------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------hqktvavsvsclhgrggggsagvrqasssapasaqrrggclmrlrsrphrwssraspysvpg
B5X9J9_SALSA/3-101                  .........................................cr--------.--.......--------..-..-.-KE..NYILLEQSVTVD......S-KEVDALVTKIGEALQLHNN....SA.NQ----------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------ktmsclhgltgncsssnikqannnngvalqkrtgcciplrnrgqrsnraspysfpgssn...
W5J9T1_ANODA/29-106                 ....................................pshqptr--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------SSRPSPYHIPCR-SWSEP..VCGG..VGV.........GA.........EKKIVGKAKTK.DeqtiDDPY..EFLQTL.LKNNNLVKEAVRRLQ------------------hgls..........................................................
B5X9A1_SALSA/106-154                .................................nfkrwdrkgi--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........------NAAVE.K....DDPH..QLLQEL.ILSGNLIKEAVRRLQF-----------------sttecvd.......................................................
F7H1S2_MACMU/140-197                ..........................................l--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------LSGPCRRGWLRG..AAAS..RRL.........QQ.........RRGSQPETRTG.D....DDPH..RLLQQL.VLSGNLIKEAVRRL-------------------..............................................................
G3MI31_9ACAR/97-156                 ............................vlsavakdcarrtca--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........--ASHQHQQES.D....KDPY..ELLQEL.LQQGTLIQEAVRRLQDNV---------------vgkkrll.......................................................
A0A023EHW1_AEDAL/66-148             .................................lkakpahqps--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.--------------------------RSSRPSPYHIPCR-SWSEP..ACGNgeKRP.........IK.........SCKKQPEEETI.-....EDPY..EFLQTL.LKNNNLVKEAVRRLQH-----------------glspkqr.......................................................
U3AXA0_CALJA/1-239                  ...........................................MPCRREEE.EE.......AGEEAEGE..E..E.EED..SFLLLEQSVALG......GSGEVDRLVAQIGETLQLDAA....QD.SPASPCAPPRAPLRAPGP.L...AAaVPADKARP.LAVPLLLPSASAETV..GPAPHGALRCALGDRGR.VRGRAAPYCV.AELAAGPSALSPLPPQADLDGPPGAGKQGVPQPLSGPCRRGWLRG..AAAS..RRL.........QQ.........RRGSQPETRTG.D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLGP..............................................................
G3UMP2_LOXAF/135-193                ..........................................l--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------LSGRCRRGWLRG..AAAS..RRL.........RQ.........RLGPRAKGRTS.D....DDSH..RLLQQL.LLSGNLIKEAVRRLR------------------..............................................................
U3CTE2_CALJA/1-239                  ...........................................MPCRREEE.EE.......AIEEAEGE..E..E.EED..SFLLLEQSVTLG......SSGEVDRLVAQIGETLQLDPA....QD.SPASPCAPPRAPLRAPGP.L...AAaVPADKARP.LAVPLLLPSASAETV..GPAPHGALRCALGDRGR.VRGRAAPYCV.AELAAGPSALSPLPPQADLDGPPGAGKQGVPQPLSGPCRRGWLRG..AAAS..RRL.........QQ.........RRGSQPETRTG.D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLGP..............................................................
FRAT1_HUMAN/1-239                   ...........................................MPCRREEE.EE.......AGEEAEGE..E..E.EED..SFLLLQQSVALG......SSGEVDRLVAQIGETLQLDAA....QH.SPASPCGPPGAPLRAPGP.L...AAaVPADKARS.PAVPLLLPPALAETV..GPAPPGVLRCALGDRGR.VRGRAAPYCV.AELATGPSALSPLPPQADLDGPPGAGKQGIPQPLSGPCRRGWLRG..AAAS..RRL.........QQ.........RRGSQPETRTG.D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLGP..............................................................
#=GR FRAT1_HUMAN/1-239        SS    ...........................................XXXXXXXX.XX.......XXXXXXXX..X..X.XXX..XXXXXXXXXXXX......XXXXXXXXXXXXXXXXXXXXX....XX.XXXXXXXXXXXXXXXXXX.X...XXXXXXXXXXX.XXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXX.XXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXX..XXX.........XX.........XXXXXXXXXXX.X....XXHH..HHHHHH.HHTT-HHHHHHHHHHXXXXXXXXXXXXXXXXXX..............................................................
L5JPM8_PTEAL/71-173                 .........................................lh--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.--------ALSPLPPQPGLDGAPEAFKRGAPQSLSGPCRRGWLRG..AAGS..RRL.........QQ.........RRGPQPEVRTG.D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLHAKLPQRPLLRP..............................................................
H3D2N6_TETNG/106-156                .....................................gdrdwd--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........QI.........RQWKRKAMAVE.E....DDPH..RLLQEL.ILSGNLIKEAVRRLQL-----------------saadc.........................................................
G3TNU2_LOXAF/1-99                   ..........................................x--------.--.......--------..-..-.---..-----EQSVTLG......GSGEVDRLVAQIGEALQLDAA....QD.SPASPCAE----------.-...--.VPADKARP.PALPLLLSPAPASAE..A-AGPGALRCTLGDRGR.VRGRAAPYCV.AELTAGPSALP----------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------..............................................................
B5DGG9_SALSA/106-152                .................................fkpwnrkris--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-------AAVE.N....DDPH..QLLQEL.ILSGNLIKEAVRRLQF-----------------sttecg........................................................
G3SG99_GORGO/1-40                   ...........................................--------.--.......--------..-..-.--D..SFLLLQQSVALG......SSGEVDRLVAQIGETLQLDAA....QH.LAA---------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------a.............................................................
B7U5G4_HALDI/67-136                 .......................cekdsssnsgnfihhklkgc--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-CKSSAVLKTE.D....DSPH..ILLQKL.LKEQTLIQEAVRRLQLKT---------------tresenkqtfr...................................................
F7H1S2_MACMU/1-142                  ...........................................MPCRREEE.EE.......AGEEAEGE..E..E.EED..SFLLLQQSVALG......SSGEVDRLVAQIGETLQLDAA....QD.SPASPCAPPGAPLRAPGP.L...AAaVPADKARP.PAVPLLLPPASAETV..GPAPPGVLRCALGDRGR.VRGRAAPYCV.AELATGPSAL-----------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------ls............................................................
H0Y0G4_OTOGA/1-237                  ...........................................MPCRREEE.EE.......AGEEAEGE..E..E.-KD..SFLLLEQSVTLG......SSGEVDKLVAQIGETLQLDAA....QD.SPASPCASLGAPLRAPRP.Q...AA.VRADEGPA.AAVQLLLPPSSSEGV..GPAPPGALRCALGDRGR.VRGRAAPYCV.AELVAGPSALPTLPLQPGQDGPLGAGKRGVSQQLSGPCRRGWLRG..AAAS..RRL.........QQ.........RRGSQPETRTN.D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLHTKLPQRPLLGP..............................................................
V4ACG1_LOTGI/20-125                 ............idnlvkgirdrlclksqeklskyrstpysii--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.----------------------------------RSPCRENGGSGlcQKCS..CKR.........NN.........WRSCCCKVKEE.D....ESPH..KLLEKL.LHEQTLIQEAVRRLTSRM---------------esansamsvpmts.................................................
U3BF68_CALJA/1-239                  ...........................................MPCRREEE.EE.......AIEEAEGE..E..E.EED..SFLLLEQSVTLG......SSGEVDRLVAQIGETLQLDAA....QD.SPASPCAPPGAPLRAPGP.L...AAaVRADKARP.PAVPLLLPPVSMETV..GPAPLGALRSTLGDRGR.VRGRAAPYCV.AELAAGPSALSPLPPQADLDGPPGAGKQGVPQPLSGPCRRGWLRG..AAAS..RRL.........QQ.........RRGSQPETRTG.D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLGP..............................................................
E0VMG3_PEDHC/85-147                 ....................clkattrhcgghscltinnktlk--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........----TKSNVTS.A....DDPY..EMLQEL.LRDGSLIKEAVRRLE------------------mglspkq.......................................................
G3INT8_CRIGR/1-235                  ...........................................MQCQRAEK.EE.......GGFEAEGE..D..K.-DD..SFLLLQQSVTLG......SLTDVDQLIALIGETLKLDTA....HD.GPASPSAAPGPP--PLRV.L...AA.ISVEQNRS.PSRQMLRSSVPAETG..APAHPRAISCMLWERWR.LRSQAAPYCV.AELTAVTSALCPVSRQPGLEGPPVTGKPSTPQPLSGPCRRGWPQS..TAMS..LPL.........QQ.........RPGSQPETHTS.D....DDPH..QLPQQL.LLSGNLIKEAVQRLHSLQLQLQANLYSHRFLK-r.............................................................
M3Z030_MUSPF/72-99                  ..........................................p--------.--.......--------..-..-.---..------------......---------------------....--.------------------.-...--.--------.---------------..-----------LGDRGR.VRGRAAPYFV.AELAAGPSALP----------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------..............................................................
G3IMA4_CRIGR/83-116                 .........................................sp--------.--.......--------..-..-.---..------------......-------LIAKIGETLKLDTA....HD.GPASQSAAQ---------.-...--.--------.---------------..-----------------.----------.---------------------------------------------..----..---.........--.........-----------.-....----..------.---------------------------------vtgigae.......................................................
#=GC SS_cons                        ...........................................XXXXXXXX.XX.......XXXXXXXX..X..X.XXX..XXXXXXXXXXXX......XXXXXXXXXXXXXXXXXXXXX....XX.XXXXXXXXXXXXXXXXXX.X...XXXXXXXXXXX.XXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXX.XXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXX..XXX.........XX.........XXXXXXXXXXX.X....XXHH..HHHHHH.HHTT-HHHHHHHHHHXXXXXXXXXXXXXXXXXX..............................................................
#=GC seq_cons                       ....................................................................................................................................................................................................................................................................................................t.t.p....cDsa..phLQpL.lhpGsLIpEAV+RLp................................................................................
//
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