GenomeNet

Database: Pfam
Entry: GSK-3_bind
LinkDB: GSK-3_bind
Original site: GSK-3_bind 
#=GF ID   GSK-3_bind
#=GF AC   PF05350.7
#=GF DE   Glycogen synthase kinase-3 binding
#=GF AU   Finn RD
#=GF SE   Pfam-B_18811 (release 7.8)
#=GF GA   25.00 25.00;
#=GF TC   26.70 32.10;
#=GF NC   22.90 24.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11738041
#=GF RT   The structure of phosphorylated GSK-3beta complexed with a
#=GF RT   peptide, FRATtide, that inhibits beta-catenin phosphorylation. 
#=GF RA   Bax B, Carter PS, Lewis C, Guy AR, Bridges A, Tanner R, Pettman
#=GF RA   G, Mannix C, Culbert AA, Brown MJ, Smith DG, Reith AD; 
#=GF RL   Structure (Camb) 2001;9:1143-1152.
#=GF DR   INTERPRO; IPR008014;
#=GF DR   SCOP; 1gng; fa;
#=GF CC   Glycogen synthase kinase-3 (GSK-3) sequentially phosphorylates
#=GF CC   four	serine residues on glycogen synthase (GS), in the sequence
#=GF CC    SxxxSxxxSxxx-SxxxS(p), by recognising and phosphorylating the
#=GF CC   first  serine in the sequence motif SxxxS(P) (where S(p)
#=GF CC   represents a	phosphoserine). Interaction of GSK-3 with a
#=GF CC   peptide derived from GSK-3 binding protein (this family)
#=GF CC   prevents GSK-3 interaction with Axin. This interaction thereby
#=GF CC   inhibits the Axin-dependent phosphorylation of  beta-catenin by
#=GF CC   GSK-3 [1]. 
#=GF SQ   63
#=GS C1BFK2_ONCMY/1-159    AC C1BFK2.1
#=GS H3D2N6_TETNG/1-163    AC H3D2N6.1
#=GS F7H1S2_MACMU/1-197    AC F7H1S2.1
#=GS G3TNU2_LOXAF/1-175    AC G3TNU2.1
#=GS H0XS45_OTOGA/1-208    AC H0XS45.1
#=GS G3T4U3_LOXAF/1-138    AC G3T4U3.1
#=GS F7GHD6_CALJA/1-215    AC F7GHD6.1
#=GS E9IBR3_SOLIN/65-170   AC E9IBR3.1
#=GS H2RXZ5_TAKRU/1-164    AC H2RXZ5.1
#=GS B5THN9_SACKO/46-125   AC B5THN9.1
#=GS FRAT2_MOUSE/1-213     AC Q8K025.1
#=GS G3MI31_9ACAR/21-154   AC G3MI31.1
#=GS G3UMP2_LOXAF/1-193    AC G3UMP2.1
#=GS B7U5G4_HALDI/30-138   AC B7U5G4.1
#=GS B5XAM6_SALSA/1-157    AC B5XAM6.1
#=GS G5C0A7_HETGA/1-44     AC G5C0A7.1
#=GS C1BY60_ESOLU/1-159    AC C1BY60.1
#=GS H2RCJ8_PANTR/1-240    AC H2RCJ8.1
#=GS C3YD04_BRAFL/689-774  AC C3YD04.1
#=GS B7PEY3_IXOSC/64-136   AC B7PEY3.1
#=GS Q53XP8_HUMAN/1-215    AC Q53XP8.1
#=GS FRAT1_HUMAN/1-240     AC Q92837.3
#=GS FRAT1_HUMAN/1-240     DR PDB; 1GNG Y; 198-223;
#=GS FRAT1_HUMAN/1-240     DR PDB; 3ZRM X; 199-221;
#=GS FRAT1_HUMAN/1-240     DR PDB; 3ZRK Y; 201-222;
#=GS FRAT1_HUMAN/1-240     DR PDB; 4AFJ Y; 200-222;
#=GS FRAT1_HUMAN/1-240     DR PDB; 1GNG X; 198-223;
#=GS FRAT1_HUMAN/1-240     DR PDB; 3ZRL Y; 201-223;
#=GS FRAT1_HUMAN/1-240     DR PDB; 4AFJ X; 200-222;
#=GS FRAT1_HUMAN/1-240     DR PDB; 3ZRK X; 199-222;
#=GS FRAT1_HUMAN/1-240     DR PDB; 3ZRM Y; 201-222;
#=GS FRAT1_HUMAN/1-240     DR PDB; 3ZRL X; 199-221;
#=GS E0VMG3_PEDHC/57-149   AC E0VMG3.1
#=GS GBP_XENLA/1-158       AC O93343.1
#=GS G3X1T2_SARHA/104-159  AC G3X1T2.1
#=GS G3N7F8_GASAC/1-160    AC G3N7F8.1
#=GS F7AUX6_MACMU/1-215    AC F7AUX6.1
#=GS Q4S8R4_TETNG/1-84     AC Q4S8R4.1
#=GS C1BIH5_OSMMO/1-157    AC C1BIH5.1
#=GS H0Y0G4_OTOGA/1-238    AC H0Y0G4.1
#=GS G3INT8_CRIGR/1-236    AC G3INT8.1
#=GS B2RU64_MOUSE/1-234    AC B2RU64.1
#=GS H2NB63_PONAB/1-239    AC H2NB63.1
#=GS Q9WVA7_MOUSE/1-233    AC Q9WVA7.1
#=GS G3X1T2_SARHA/1-106    AC G3X1T2.1
#=GS G1KZR6_AILME/2-145    AC G1KZR6.1
#=GS H0WCQ4_CAVPO/2-194    AC H0WCQ4.1
#=GS G1QDF2_MYOLU/1-94     AC G1QDF2.1
#=GS Q9YI01_DANRE/1-148    AC Q9YI01.1
#=GS FRAT2_HUMAN/1-215     AC O75474.3
#=GS B5DGD3_SALSA/1-158    AC B5DGD3.1
#=GS G3IMA4_CRIGR/1-86     AC G3IMA4.1
#=GS G5C0A7_HETGA/42-93    AC G5C0A7.1
#=GS G1SBR4_NOMLE/1-214    AC G1SBR4.1
#=GS G3N174_BOVIN/1-212    AC G3N174.1
#=GS E2ACG4_CAMFO/75-155   AC E2ACG4.1
#=GS G3SG99_GORGO/1-159    AC G3SG99.1
#=GS H2Q2C6_PANTR/1-215    AC H2Q2C6.1
#=GS G1KZR5_AILME/1-107    AC G1KZR5.1
#=GS G3INT0_CRIGR/1-112    AC G3INT0.1
#=GS G1SPD8_RABIT/1-220    AC G1SPD8.1
#=GS G3X1Y7_SARHA/13-175   AC G3X1Y7.1
#=GS G3IHX4_CRIGR/1-108    AC G3IHX4.1
#=GS FRAT1_MOUSE/1-234     AC P70339.2
#=GS H9HVH4_ATTCE/62-164   AC H9HVH4.1
#=GS B5DGG9_SALSA/1-157    AC B5DGG9.1
#=GS E1BNA0_BOVIN/1-235    AC E1BNA0.2
#=GS B5X9A1_SALSA/1-158    AC B5X9A1.1
#=GS D2H5L3_AILME/38-178   AC D2H5L3.1
#=GS D3DR49_HUMAN/1-175    AC D3DR49.1
#=GS D3Z8R0_RAT/1-234      AC D3Z8R0.1
#=GS B5X9J9_SALSA/1-158    AC B5X9J9.1
#=GS F1PSH0_CANFA/1-146    AC F1PSH0.1
C1BFK2_ONCMY/1-159               ...............................................MPCRKE---------.......--...-...----NYILLEQSVTVD-SKEVDALVTKIGEALQLHNNSA.NQK.TMSCLHG--.......---LNGNCSSSNIKQ------...--ANNNNNGVAQQKRTGCCIRLRNRGQRsNRASPY----SFPGSSNQ..EWDNF....................----KPWNR----..-KR...--.----.........---I.SAAVENDDPH..QLLQELILSGNLIKEAVRRLQFS-----------------ttecgdlsdn....................................
H3D2N6_TETNG/1-163               ...............................................MPCRKE---------.......--...-...----NYILLEQSVTVG-SKEVDALVTRIGEALQLHNNGG.GHQ.KTVAVS---.......---VSCLHGRGGGGS--AGVR...QASSSAPASAQRRGGCLMRLRSRPHRWS.SRASPYSVP---GSDGDR..DWDQI....................----RQWKR----..---...--.----.........---K.AMAVEEDDPH..RLLQELILSGNLIKEAVRRLQLSA----------------adcgefpqaa....................................
F7H1S2_MACMU/1-197               ...............................................MPCRREEEEEAGEEA.......EG..eE...EEEDSFLLLQQSVALGSSGEVDRLVAQIGETLQLDAAQD.SPA.SPCAPPGAPl....raPGPLAAAVPADKARPPAVPLL...LPPASAETVGPAPPGVLRCALGDRGRVR.GRAAPYCVAELATGPSAL..L---S....................GPCRRGWLRGAAA..SRR...LQ.QRRG.........SQPE.TRTGD-DDPH..RLLQQLVLSGNLIKEAVRRL--------------------..............................................
G3TNU2_LOXAF/1-175               ..............................................x---------------.......--...-...---------EQSVTLGGSGEVDRLVAQIGEALQLDAAQD.SPA.SPCA-----.......------EVPADKARPPALPLL...LSPAPAS-AEAAGPGALRCTLGDRGRVR.GRAAPYCVAELTAGPSAL..P----....................GPCRRGWLRGAAT..ANR...LQ.QRRW.........PQAG.TRAGN-DGSHddRLLQQLVLSGNLIKEAVRRLQRAVAAAAA-----------vagglsgpdp....................................
H0XS45_OTOGA/1-208               ...............................................MPCGREEEEEAGEEA.......E-...-...EEEDSFLLLEQSVTLGSSGEVDRLVAQIGETLQLDAAQD.SPA.SPCAPPGAP.......-LRPPAAVPADKAWAPAVPLL...WPPASAEVVGPALPGTLRCALGDRGRVR.GRAAPYCVAELAAGPSAL..P----....................GPCRRGWLRGAVA..SRR...LP.QRRW.........TQTG.AHAGD-DDPH..RLLQQLVVSGNLIKEAVRRLQRAVAAVAATGPVGT-PGP-v.............................................
G3T4U3_LOXAF/1-138               ..............................................a---------------.......--...-...---------------------------------------.---.---------.......---------------------...---------GPAPPGALYSTFGDCGSVR.DWAEPYLVAEFAPGPTAL..SLLPPqpgfegtpgsgkpgasrqlsGRCRRGWLRGAAA..SRR...LR.QRLG.........PRAK.GRTSD-DDSH..RLLQQLLLSGNLIKEAVRRLRSRRLHLYAKLPQRRLPGPV..............................................
F7GHD6_CALJA/1-215               ...............................................MPCRREEEEEAIEEA.......EG..eE...EEEDSFLLLEQSVTLGSSGEVDRLVAQIGETLQLDAAQD.SPA.SPCAPPRAPl....raPGPLAAAVPADKARPLAVPLL...LPSASAETVGPAPHGALRCALGDRGRVR.GRAAPYCVAELAAGPSTL..P----....................GPCRRGWLRDAVT..SRR...LQ.QRRW.........TQAG.ARAGD-DDPH..RLLQQLVLSGNLIKEAVRRLQRAVAAVAATSPASA-----agpg..........................................
E9IBR3_SOLIN/65-170              .............................arswadpaagcevcglrs---------------.......--...-...---------------------------------------.---.---------.......---------------------...----------------------------.------------SGQQQQ..QQQQQq..................qNPAGHHHHHHHHH..HHH...HH.HHYH.........LKRS.ERSRVDDDPY..EVLQELLREGGLIKEAVKRLQENLDELSSSEADED-----dvvd..........................................
H2RXZ5_TAKRU/1-164               ...............................................MPCRKE---------.......--...-...----NYIFLEQSVTVD-SKEVDALVTRIGEALQLHGGGGgHQK.TVSVSVS--.......--CLHGLTGSSSAGI-----K...QANSSAAASAQRRGGCYMRLRSRPHRWN.RRASPY----NIPGSSGE..Q----....................-----DWDR----..---...IK.Q--W.........-NGK.TMAAEEEDPH..RLLQELILSGNLIKEAVRRLQFSAADCAEFPPA-------pd............................................
B5THN9_SACKO/46-125              ........................................ahraspy---------------.......--...-...---------------------------------------.---.---------.......---------------------...----------------------------.------------------..----H....................SPCKHCRTGQVCH..SKDcsyLR.HTHS.........KRIK.KKTGD-NDAH..KLLEQLLRQGNLIKEAVGRLN-------------------fksepkckyssqw.................................
FRAT2_MOUSE/1-213                ...............................................MPCRREEEEEAGDEA.......EG...E...EDDDSFLLLQQSVTLGGSTDVDRLIVQIGETLQLDTAHD.RPA.SPCAAPGPPp.....aPPRVLAALSADKTGTPARRLL...RPTGSAETGDPAPPGAVRCVLGERGRVR.GRSAPYCVAEIAPGASAL..P----....................GPGRRGWLPGSVA..SHR...IQ.QRRW.........TAGG.ARAAD-DDPH..RLLQQLVLSGNLIKEAVRRLQRAVAAVAATSPASA-PGS-g.............................................
G3MI31_9ACAR/21-154              ..........aqamprngniivvenvlssegssvlgkaaeveedlas---------------.......--...-...---------------------------------------.---.---------.......---------------------...-------------------AIKENLKLK.SHQQPCHVCGQQRHPRYS..PYLVP....................RRSESSGVLSAVA..KDC...-A.RRTC.........AASHqHQQESDKDPY..ELLQELLQQGTLIQEAVRRLQDNV----------------vgkkr.........................................
G3UMP2_LOXAF/1-193               ...........................................epgr----QRRPQSSGCPG.......RG...P...CRADSFLLLEQPARLGGSAEVDRLVAQIGEALQLDPAQD.SPA.SLCAPPWQPl.....qPPLPLAEVPAYRARPPALPLH...LPPSSVEATN---LGALYSTFGDCGSVR.DWAEPYLVAEFAPGPTAL..L---S....................GRCRRGWLRGAAA..SRR...LR.QRLG.........PRAK.GRTSD-DDSH..RLLQQLLLSGNLIKEAVRRLR-------------------..............................................
B7U5G4_HALDI/30-138              ............................................erl---------------.......--...-...---------------------------------------.---.---------.......---------------------...------------------C-LKSREKLHsYRKTPYTPI--GHRASNG..YGRIS...................nLCCEKDSSSNSGNfiHHK...LK.GCCK.........SSAV.LKTED-DSPH..ILLQKLLKEQTLIQEAVRRLQLKT----------------tresenkqtfrps.................................
B5XAM6_SALSA/1-157               ...............................................MPCRKE---------.......--...-...----NYILLEQSVTVD-SKEVDALVTKIGEALQLHNNSA.NQK.TMSCLHG--.......---LTGNCSSSNIKQ------...---ANNNNGVALQKRTGCCIPLRNRGQR.NRASPY----SFPGSSNQ..EWDNF....................----KPWNR----..-KR...--.----.........---I.SAAVENDDPH..QLLQELILSGNLIKEAVRRLQF------------------sttgcgdlsdn...................................
G5C0A7_HETGA/1-44                ...............................................MPCRREEEEEAGEEA.......EG...E...EEEGSFLLLEQSVTLGGSGEVDRL---------------.---.---------.......---------------------...----------------------------.------------------..-----....................-------------..---...--.----.........----.----------..----------------------------------------pe............................................
C1BY60_ESOLU/1-159               ...............................................MPCRKE---------.......--...-...----NYILLEQSVTVD-SKEVDALVTKIGEALQLHNNNSaNQK.TMSCLHG--.......---LTSNGSSSNVKQ------...---ATHNNGVALQKRTGCCMRLRNMGQRsNRASPY----SFPGSSNQ..EWDHF....................----KPWNRKIIN..---...--.----.........----.-AAVENDDPH..QLLQELILSGNLIKEAVRRSQFST----------------aecgehsgn.....................................
H2RCJ8_PANTR/1-240               ...............................................MPCRREEEEEAGEEA.......EG..eE...EEEDSFLLLQQSVALGSSGEVDRLVAQIGETLQLDAAQH.SPA.SPCGPPGALl....raPGPLAAAVPADKARSPAVPLL...LPPASAETVGPAPPGVLRCALGDRGRVR.GRAAPYCVAELATGPGAL..SPLPPqadldgppgagkqgipqplsGPCRRGWLRGAAA..SRR...LQ.QRRG.........SQPE.TRTGD-DDPH..RLLQQLVLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLGP-l.............................................
C3YD04_BRAFL/689-774             .......................................kqrvgreq---------------.......--...-...---------------------------------------.---.---------.......---------------------...-----------------------RMAAT.QRASPYALP--------L..ANKSG....................AVCKKSPPR---N..ARR...LL.QRR-.........----.---CDSEDPY..AMLQELLRSGNLIKEAVKRLGSR-----------------getgrtrear....................................
B7PEY3_IXOSC/64-136              ............................ipkrteaggvvsavpkdvv---------------.......--...-...---------------------------------------.---.---------.......---------------------...----------------------------.------------------..-----....................-------------..---...--.-RRT.........C-AN.HHQDADKDPY..EMLQDLLRQGTLIQEAVRRLQENVV---------------gktkaphsldsss.................................
Q53XP8_HUMAN/1-215               ...............................................MPCRREEEEEAGEEA.......EG..eE...EEDDSFLLLQQSVTLGSSGEVDRLVAQIGETLQLDAAQD.SPA.SPCAPPGVPl....raPGPLAAAVPTDKARPPAVPLL...LPPASAETVGPAPSGALRCALGDRGRVR.GRAAPYCVAEVAAGPSAL..P----....................GPCRRGWLRDAVT..SRR...LQ.QRRW.........TQAG.ARAGD-DDPH..RLLQQLVLSGNLIKEAVRRLQRAVAAVAATGPASA-PGP-g.............................................
FRAT1_HUMAN/1-240                ...............................................MPCRREEEEEAGEEA.......EG..eE...EEEDSFLLLQQSVALGSSGEVDRLVAQIGETLQLDAAQH.SPA.SPCGPPGAPl....raPGPLAAAVPADKARSPAVPLL...LPPALAETVGPAPPGVLRCALGDRGRVR.GRAAPYCVAELATGPSAL..SPLPPqadldgppgagkqgipqplsGPCRRGWLRGAAA..SRR...LQ.QRRG.........SQPE.TRTGD-DDPH..RLLQQLVLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLGP-l.............................................
#=GR FRAT1_HUMAN/1-240     SS    ...............................................XXXXXXXXXXXXXXX.......XX..XX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXX.XXXXXXXXXX....XXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXX...XX.XXXX.........XXXX.XXXXX-XXHH..HHHHHHHHTT-HHHHHHHHHHXXXXXXXXXXXXXXXXXX-X.............................................
E0VMG3_PEDHC/57-149              .........................................aahnra---------------.......--...-...---------------------------------------.---.---------.......---------------------...----------------------------.SRPSPYRIPSRSRSWGE-..--GAC....................EDCLKATTRHCGG..HSC...LTiNNKT.........LKTK.SNVTSADDPY..EMLQELLRDGSLIKEAVRRLE-------------------mglspkqry.....................................
GBP_XENLA/1-158                  ...............................................MPCRKE---------.......--...-...----SFLLLEQSVTVG-SGEVDTLVARIGEALQLN-AQR.TPT.SCSMAYG--.......-----ALKPVSRAGP------...---------------SCSC-------VR.GRSTPYPVC-TPRGAARH..AQHHHhhsprq.......qgtggnkRLCGRGWGR--CN..CRK...--.----.........---H.AGTEEEDDPH..ELLQELLLSGNLIKEAVRRLH-----MAGESPDP--PG--sr............................................
G3X1T2_SARHA/104-159             ...........................................aphr---------------.......--...-...---------------------------------------.---.---------.......---------------------...----------------------------.------------------..-----....................-------------..---...--.----.........GQPG.LRAGG-NDSH..RLLQQLLLSGDLIKEAVRRLQRAVAAVTGAGSSA------tpdts.........................................
G3N7F8_GASAC/1-160               ...............................................MPCRKE---------.......--...-...----NYIFLEQSVTVD-SKEVDALVTKIGEALQLHNNNS.-GG.GIQKTVS--.......-VSVSCLHGLTGGGNPA----...----AVIAGAPAQRRHGCCMRLRNHRGSsSRASPYSVP---GSNGDR..DWDQI....................----KPWHK----..-KR...--.----.........----.-IEAEEDDPH..RLLQELILSGNLIKEAVRRLQFSA----------------aecgdfpkav....................................
F7AUX6_MACMU/1-215               ...............................................MPCRREEEEEAGEEA.......EG..eE...EEEDSFLLLQQSVTLGSSGEVDRLVAQIGETLQLDAAQD.SPA.SPCAPPGAPl....raPGSLAAAVPADKARPPAVPLL...LPPASAETVGPAPPGALRCALGDRGRVR.GRAAPYCVAELAAGPSAL..P----....................GPCRRGWLRDAVT..SRR...LQ.QRRW.........TQAG.ARSGD-DDPH..RLLQQLVLSGNLIKEAVRRLQRAVAAVAATGPASA-PGP-g.............................................
Q4S8R4_TETNG/1-84                .....................mrlrsrphrwssraspysvpgsdgdr---------------.......--...-...---------------------------------------.---.---------.......---------------------...----------------------------.------------------..-----....................-------------..--D...WD.QIRQ.........WKRK.AMAVEEDDPH..RLLQELILSGNLIKEAVRRLQLSAA---------------dcgefpqaadsv..................................
C1BIH5_OSMMO/1-157               ...............................................MPCRKE---------.......--...-...----NYILLEQSVTVD-SKEVDALVTKIGEALQLHNNSA.NQK.TMSCLHG-L.......NGSSNVKQPNNNNGAPI---L...QK----------RTG--CCMRLRKRGQRsSRASPY----NIPGSSDQ..EWDHF....................----KPWNR----..-KR...--.----.........----.-VNVEEDDPH..QLLQELILSGNLIKEAVRRLQFST----------------tecgdhskmtet..................................
H0Y0G4_OTOGA/1-238               ...............................................MPCRREEEEEAGEEA.......EG...E...EEKDSFLLLEQSVTLGSSGEVDKLVAQIGETLQLDAAQD.SPA.SPCASLGAPl.....rAPRPQAAVRADEGPAAAVQLL...LPPSSSEGVGPAPPGALRCALGDRGRVR.GRAAPYCVAELVAGPSAL..PTLPLqpgqdgplgagkrgvsqqlsGPCRRGWLRGAAA..SRR...LQ.QRRG.........SQPE.TRTND-DDPH..RLLQQLVLSGNLIKEAVRRLHSRRLQLHTKLPQRPLLGP-l.............................................
G3INT8_CRIGR/1-236               ...............................................MQCQRAEKEEGGFEA.......EG...E...DKDDSFLLLQQSVTLGSLTDVDQLIALIGETLKLDTAHD.GPA.SPSAAPGPP.......PLRVLAAISVEQNRSPSRQML...RSSVPAETGAPAHPRAISCMLWERWRLR.SQAAPYCVAELTAVTSAL..CPVSRqpglegppvtgkpstpqplsGPCRRGWPQSTAM..SLP...LQ.QRPG.........SQPE.THTSD-DDPH..QLPQQLLLSGNLIKEAVQRLHSLQLQLQANLYSHRFLK--rl............................................
B2RU64_MOUSE/1-234               ...............................................MPCRREEEEEAGDEA.......EG...E...EDDDSFLLLQQSVTLGGSTDVDQLIVQIGETLQLDAAHD.RPA.SPCAAPGPP.......PPQVLAALPADKTGTPARRLL...RPTGSAETGNPAPPGAVRCVLGERGRVR.GRSAPYCVAEISPGASAL..PQQPGldgppgtg...klstpqplsGPCRRGWLRNAAA..SRR...LQ.QRRG.........SQPE.TRTGDDDDPH..RLLQQLVLSGNLIKEAVRRLHSRQLQLHAKLPAHPFLGP-l.............................................
H2NB63_PONAB/1-239               ...............................................MPCRREEEEEAGEEA.......EG..eE...EEEDSFLLLQQSVPLGSSGEVDRLVAQIGETLQLDAAQH.SPA.SPCGPPGAPl....raPGPLAAAVXXXXWTRRSTARP...RVRALAETVGPAPPG-LRCALGDRGRVR.GRAAPYCVAELATGPSAL..SPLPPqadldgppgagkqgipqplsGPCRRGWLRGAAA..SRR...LQ.QRRG.........SQPE.TRTGD-DDPH..RLLQQLVLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLGP-l.............................................
Q9WVA7_MOUSE/1-233               ...............................................MPCRRE--EEAGDEA.......EG...E...EDDNSFLLLQQSVTLGGSADVDRLIAQIGETLQLDARHD.GPA.SPCAAPGPPp.....aPPRVLAALPADKAGAPARRLL...RRAASAEAGDPAPPGAVRCVLGERGRLR.GRAAPYCVAEIAPGASAL..PQQLGlevspgmg...kvsipqplsGRCRRGWLRNAAA..SRR...QQ.QRRG.........SQSE.TRTSD-GDPP..RLLQQLLLSGNLIKEAVRRLHSRGLQLQAKLPAHSFLGP-l.............................................
G3X1T2_SARHA/1-106               ...............................................MPCRREEEDEDDETAasgedddEG..eG...EEEESFLVLQQSVTVGGSGDVDRLVAQIGELLRLDAAHV.SPA.AAGGP----.......---------------------...----------------------------.------------------..-----....................-------------..---...--.----.........----.----------..----------------------------------------vqahlasrrrplppsaapapppppppppapaph.............
G1KZR6_AILME/2-145               ..........................................plftn------QPEEAGEEA.......EGeaeE...EEEDSFLLLEQSVTLGGSGEVDLLVAQIGETLQLDAAQD.SPA.SPCAPPGPPaagrrrlPPP--ATAPRAPARIPHRRRRpapAPAAAGALGEP-HQGGRAEASFETAAVT.RKASPTPALRASVGPSA-..-----....................-------------..---...--.----.........----.----------..----------------------------------------..............................................
H0WCQ4_CAVPO/2-194               ............................................rag----KEEEDREVQGW.......SR...V...EEDQSFLLLEQTVTLGGSGEVDRL----GGPDRQDAAVW.TRHpTARPSPGAP.......PGP-----PLQPPRPPAASLR...LPRVS----------AVRCALGDRGRVR.GRTAPYGVAELAADPGVL..P----....................RPCRREWLQGSVA..SRR...LQ.QRRW.........THAA.ARAGSDDDPH..RLLQQLVLSGNLIKEAVRRLQRAVAAVAATSPVGT-PG--pd............................................
G1QDF2_MYOLU/1-94                ..............................................v-PGGKEEKGKPGRKR.......RG...EerrEDQGNFLLLERSVTLGGSGEVDRLVAQIGETLQLDAGQD.SPA.SLCAPPGPPl.....qPPRPPAAVLADKARPPDX---...----------------------------.------------------..-----....................-------------..---...--.----.........----.----------..----------------------------------------rt............................................
Q9YI01_DANRE/1-148               ...............................................MPCRKE---------.......--...-...----NYIFLEQSVTVD-SKEVDALVSKIGEALQLHNNSS.SQK.AMSRLHG--.......---FTGSKPNGGGGS------...------------STGGQRCIRLRSRSLRtSRASPY----NPPGSSDQ..EWDHF....................---KSSWNR----..---...--.----.........----.-KKIDEDDPH..QLLQELILSGNLIKEAVRRLQ-----FSSEPSDHDIPKS-v.............................................
FRAT2_HUMAN/1-215                ...............................................MPCRREEEEEAGEEA.......EG..eE...EEDDSFLLLQQSVTLGSSGEVDRLVAQIGETLQLDAAQD.SPA.SPCAPPGVPl....raPGPLAAAVPADKARPPAVPLL...LPPASAETVGPAPSGALRCALGDRGRVR.GRAAPYCVAEVAAGPSAL..P----....................GPCRRGWLRDAVT..SRR...LQ.QRRW.........TQAG.ARAGD-DDPH..RLLQQLVLSGNLIKEAVRRLQRAVAAVAATGPASA-PGP-g.............................................
B5DGD3_SALSA/1-158               ...............................................MPCRKE---------.......--...-...----NYILLEQSVTVD-SKEVDALVTKIGEALQLHNNST.NQK.TMC-LHG--.......---LTSNCSSSNITK------...--QANNNNGVALQKRTGCCIRLRNRRQRsNRTSPY----SFPGSSNQ..EWDNF....................----KRWDRKGIN..---...--.----.........----.-AAVEKDDPH..QLLQELILSGNLIKEAVRRLQFS-----------------ttecvdisdn....................................
G3IMA4_CRIGR/1-86                ...............................................MPSQRA-EKEAGFEA.......EG...E...DKDDSFLLLQQSVTLSNLTDVDQLIAKIGETLKLDTAHD.GPA.SPSAAPGPP.......PLRVLAAISVEQNRSP-----...----------------------------.------------------..-----....................-------------..---...--.----.........----.----------..----------------------------------------li............................................
G5C0A7_HETGA/42-93               .............................................lp---------------.......--...-...---------------------------------------.---.---------.......---------------------...----------------------------.------------------..-----....................-------------..---...--.----.........---E.PRAGD-DDPH..RLLQQLVLSGNLIKEAVRRLHARRLQLQAKLPQGPLLGP-l.............................................
G1SBR4_NOMLE/1-214               ...............................................MPCRREEEEEAGEEA.......EG...E...EEEDSFLLLQQSVTLGSSGEVDRLVAQIGETLQLDAAQD.SPA.SPCAPPGAPl....raPGPLAAAVQADKARPPAVPLL...LPPASAETVGPAPSGALRCALGDRGRVR.GRAAPYCVAEFAAGPSAL..P----....................GPCRRGWLRDAVT..SRR...LQ.QRRW.........TPAG.ARAGD-DDPH..RLLQQLVLSGNLIKEAVRRLQRAVAAVAATGPASA-PGP-g.............................................
G3N174_BOVIN/1-212               ...............................................MPCRREEEEEAGEEE.......--...E...EEEDSILLLEQSVTVGGSVEVDRLVAQIGETLQLDAAQD.RPA.SACAPPGPPl.....qPPRPPAAVRADKARAPAQPLL...LPAVSVEAGGPAPSGALRCALGDRGRVR.GRAAPYFVAELATGASTL..P----....................GPCRRGWLRGAVT..SRR...LP.QRRW.........PPAG.ARAND-DDPH..RLLQQLVLSGNLIKEAVRRLQRAVAAVAATGPAGP-----agpga.........................................
E2ACG4_CAMFO/75-155              ..............cevcglrsssqshqqqnhvtaghhhhyhshlkr---------------.......--...-...---------------------------------------.---.---------.......---------------------...----------------------------.------------------..-----....................-------------..---...--.----.........---T.ERNRVDDDPY..EVLQELLREGGLIKEAVKRLQANLDEFSSSEVDE------dee...........................................
G3SG99_GORGO/1-159               ...............................................---------------.......--...-...---DSFLLLQQSVALGSSGEVDRLVAQIGETLQLDAAQH.---.---------.......---LAAAVPADKARSPAVPLL...LPPASAETVGPAPPGVLRCALGDRGRLR.GRAAPYCVAELATGPSAL..S-PLS....................GPCRRGWLRGAAA..SRR...LQ.QRRG.........SQPE.TRTGD-DDPH..RLLQQLVLSGNLIKEAVRRL--------------------..............................................
H2Q2C6_PANTR/1-215               ...............................................MPCRREEEEEAGEEA.......EG..eE...EEEDSFLLLQQSVTLGSSGEVDRLVAQIGETLQLDAAQH.SPA.SPCAPPGVPl....raPGPLAAAVPADKARPPAVPLL...LPPASAETVGPAPSGALRCALGDRGRVR.GRAAPYCVAEVAAGPSAL..P----....................GPCRRGWLRDAVT..SRR...LQ.QRRW.........TQAG.ARAGD-DDPH..RLLQQLVLSGNLIKEAVRRLQRAVAAVAATGPASA-PGP-g.............................................
G1KZR5_AILME/1-107               ...............................................---------EAGEEA.......EGeaeE...EEEDSFLLLEQSVTLGGSGEVDLLVAQIGETLQLDAAQD.SPA.SPCAPPGPPa....aaPGHTKSASKMLYGKPQLARMD...LPPSSATTRLFFPGG-------------.------------------..-----....................-------------..---...--.----.........----.----------..----------------------------------------lcsig.........................................
G3INT0_CRIGR/1-112               ............................................mlw---------------.......--...-...---------------------------------------.---.---------.......---------------------...----------------------EPRRLQ.SRAAPYCMVELTPDASAL..CPVSQqpglegppvtgkpstlqplsGPCWRGWPQSTAM..SRL...LQ.QRCG.........SQPD.THTSD-EDPH..QLLQQLLLSGNLIKEAVQ----------------------apivlvm.......................................
G1SPD8_RABIT/1-220               ........................................tpaprpq-------KRKRCEQA.......RG..rA...ERRTSFLLLEQSVTLGGSGEVDRLVAQIGETLQLDAAQD.SPA.SPCAPPGRHs.....sSPRGLGAVRADKAWSPGVPLL...RRLSLAEAVDG-SPGAVRCALGDRAPLL.RRSAPYCLVRAGRGFGKQgiPQPLS....................GPCRRGWLRGAAS..SRR...LQ.QRRG.........SQPE.TRTSD-DDPH..RLLQQLVLSGNLIKEAVRRLHSRRLQLRPKLPPCQLPGP-l.............................................
G3X1Y7_SARHA/13-175              ....xxxxxxpapaslqpsgplqcpgngagaalswandvgavaplps---------------.......--...-...---------------------------------------.---.---------.......---------------------...---------------------------R.VQSSP-CVPGGAPGRSST..SAPHIckrgl..........pqplaGPCRRTWLRGAAA..SRR...LQ.QQHHhqhpqyryrGQPG.LRAGE-DDPH..QLLQQLVLSGNLIKEAVRRLHSRRPRL-------------ylgaraplpqepsppp..............................
G3IHX4_CRIGR/1-108               ...............................................MPCQSA-EKEAGFET.......EG...E...DKDDSFLLLQQSVTLGSLTDVDQLIAKIGETLKQI----.--F.CVCRDRG-P.......SSPWSHSLHAVRTGA------...----------------------------.------------------..-----....................-------------..---...--.----.........----.----------..----------------------------------------cgagqlptvwqssprapasyplcpcslalrdl..............
FRAT1_MOUSE/1-234                ...............................................MPCRREEEEEAGDEA.......EG...E...EDDDSFLLLQQSVTLGGSTDVDQLIVQIGETLQLDAAHD.RPA.SPCAAPGPP.......PPQVLAALPADKTGTPARRLL...RPTGSAETGNPAPPGAVRCVLGERGRVR.GRSAPYCVAEISPGASAL..PQQPGldgppgtg...klstpqplsGPCRRGWLRNAAA..SRR...LQ.QRRG.........SQPE.TRTGDDDDPH..RLLQQLVLSGNLIKEAVRRLHSRQLQLHAKLPAHPFLGP-l.............................................
H9HVH4_ATTCE/62-164              rvparswadpaagcevcglrsngqqqqqsqqhhvtaahhhhhhhhhh---------------.......--...-...---------------------------------------.---.---------.......---------------------...----------------------------.------------------..-----....................-------------..---...--.YHNH.........LKRS.ERRV-DDDPY..EVLQELLREGGLIKEAVKRLQENLDELSSSEVDE------ndvvn.........................................
B5DGG9_SALSA/1-157               ...............................................MPCRKE---------.......--...-...----NYILLEQSVTVD-SKEVDALVTKIGEALQLHNNSA.NQK.TMSCLHG--.......---LTGNCSSSNIKQ------...---ANNNNGVALQKRTGCCIPLRNRGQR.NRASPY----SFPGSSNQ..EWDNF....................----KPWNR----..-KR...--.----.........---I.SAAVENDDPH..QLLQELILSGNLIKEAVRRLQFS-----------------ttecgdlsdn....................................
E1BNA0_BOVIN/1-235               ...............................................MPCRREEEEEAGEE-.......--...E...EEEDSFLLLEQSVTVGGSVEVDRLVAQIGETLQLDAAQD.RPA.SACAPPGPPl.....qPPRSPAAVRADKARAPAQPLL...LPAASIEAGGPAPLGALRCALGDRGRVR.GRAAPYFVAELAAGPTAL..SPLPPqpsldgplgadkrgspqplsGPCRRGWLRDAAA..SRR...LQ.HRRG.........LQPP.ARNGD-DDPH..RLLQQLVLSGNLIKEAVRRLHSRRLQLHAKLPQRQLLGP-l.............................................
B5X9A1_SALSA/1-158               ...............................................MPCRKE---------.......--...-...----NYILLEQSVTVD-SKEVDALVTKIGEALQLHNNST.NQK.TMC-LHG--.......---LTSNCSSSNIT-------...-KQANNNNGVALQKRTRCCIRLRNRRQRsNRTSPY----SFPGSSNQ..EWDNF....................----KRWDRKGIN..---...--.----.........----.-AAVEKDDPH..QLLQELILSGNLIKEAVRRLQFS-----------------ttecvdisdn....................................
D2H5L3_AILME/38-178              ..........................................nkgtg---------RAGEEA.......EGeaeE...EEEDSFLLLEQSVTLGGSGEVDLLVAQIGETLQLDAAQD.SPA.SPCAPPGPPaagrrrlPPP--ATAPRAPARIPHRRRRpapAPAAAGALGEP-HQGGRAEASFETAAVT.RKASPTPALRASVGPSA-..-----....................-------------..---...--.----.........----.----------..----------------------------------------..............................................
D3DR49_HUMAN/1-175               ...............................................MPCRREEEEEAGEEA.......EG..eE...EEEDSFLLLQQSVALGSSGEVDRLVAQIGETLQLDAAQH.SPA.SPCGPPGAPl....raPGPLAAAVPADKARSPAVPLL...LPPALAETVGPAPPGVLPCALGDRGRVR.GRAAPYW-----------..-----....................-------------..---...--.----.........----.----------..----------------------------------------rwprlqqapgrcphcplrptlmglrelasrasrsrcrvragedgsg
D3Z8R0_RAT/1-234                 ...............................................MPCLRE-EEEASDQA.......DG...E...EDNDSFLLLQQSVTLGGSADVDQLIARIGETLQLDTAHD.SPA.SQCAAPGPPp.....aPPRVLAALPADKARAPTRRLL...RLAASPETWDPAPPGAMRCVLGERGRVR.DRAAPYSVAEIAPGPSVL..PQQQGlegpqgtg...klsipqplsGPCRRGWLRNTAA..SRR...LQ.QRRG.........SHLE.TRTGE-DDPP..RLLQQLLLSGNLIKEAVRRLHSRRLQLQAKLPAHPFLEP-l.............................................
B5X9J9_SALSA/1-158               ...............................................MPCRKE---------.......--...-...----NYILLEQSVTVD-SKEVDALVTKIGEALQLHNNSA.NQK.TMSCLHG--.......---LTGNCSSSNIKQ------...---ANNNNGVALQKRTGCCIPLRNRGQRsNRASPY----SFPGSSNQ..EWDNF....................----KPWNR----..-KR...--.----.........---I.SAAVENDDPH..QLLKELILSGNLIKEAVRRLQFS-----------------ttecgdlsdn....................................
F1PSH0_CANFA/1-146               ...............................................---------------.......--...-...---DSFLLLEQSVTLSGSSEVDLLVAQIGETLQLDAAQD.SPA.SQPQRPP--.......-----VAVRADKARPPALPLL...TL----RPRGPRPRAGSGCALK-R--GR.ARRGPQ--RAVRKGPSAR..LTG--....................-------PR----..ERT...LQ.QRRG.........PQPE.SRTGD-DDPH..RLLQQLVLSGNLIKEAVRRL--------------------..............................................
#=GC SS_cons                     ...............................................XXXXXXXXXXXXXXX.......XX..XX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXX.XXXXXXXXXX....XXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXX...XX.XXXX.........XXXX.XXXXX-XXHH..HHHHHHHHTT-HHHHHHHHHHXXXXXXXXXXXXXXXXXX-X.............................................
#=GC seq_cons                    ...............................................MPst+c.............................salLLpQSVTls.StEVDtLVspIGEsLQLcssps.s.t.o.ss..G..............ush.sspst.............s..........tshtChhhcptthR.sRuuPY......sGsos................................+sW.R.......+c......................t.s+ss-.DDPH..cLLQpLlLSGNLIKEAVRRLp.t.................h.............................................
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