GenomeNet

Database: Pfam
Entry: GSK-3_bind
LinkDB: GSK-3_bind
Original site: GSK-3_bind 
#=GF ID   GSK-3_bind
#=GF AC   PF05350.11
#=GF DE   Glycogen synthase kinase-3 binding
#=GF AU   Finn RD
#=GF SE   Pfam-B_18811 (release 7.8)
#=GF GA   25.00 25.00;
#=GF TC   26.70 25.30;
#=GF NC   23.70 24.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11738041
#=GF RT   The structure of phosphorylated GSK-3beta complexed with a
#=GF RT   peptide, FRATtide, that inhibits beta-catenin phosphorylation. 
#=GF RA   Bax B, Carter PS, Lewis C, Guy AR, Bridges A, Tanner R, Pettman
#=GF RA   G, Mannix C, Culbert AA, Brown MJ, Smith DG, Reith AD; 
#=GF RL   Structure (Camb) 2001;9:1143-1152.
#=GF DR   INTERPRO; IPR008014;
#=GF DR   SCOP; 1gng; fa;
#=GF CC   Glycogen synthase kinase-3 (GSK-3) sequentially phosphorylates
#=GF CC   four  serine residues on glycogen synthase (GS), in the sequence
#=GF CC    SxxxSxxxSxxx-SxxxS(p), by recognising and phosphorylating the
#=GF CC   first  serine in the sequence motif SxxxS(P) (where S(p)
#=GF CC   represents a  phosphoserine). Interaction of GSK-3 with a
#=GF CC   peptide derived from GSK-3 binding protein (this family)
#=GF CC   prevents GSK-3 interaction with Axin. This interaction thereby
#=GF CC   inhibits the Axin-dependent phosphorylation of  beta-catenin by
#=GF CC   GSK-3 [1]. 
#=GF SQ   93
#=GS E9IBR3_SOLIN/111-165      AC E9IBR3.1
#=GS G3IMA4_CRIGR/1-85         AC G3IMA4.1
#=GS G3T4U3_LOXAF/1-137        AC G3T4U3.1
#=GS FRAT2_HUMAN/1-214         AC O75474.3
#=GS G3X1T2_SARHA/1-98         AC G3X1T2.1
#=GS F7AUX6_MACMU/1-214        AC F7AUX6.1
#=GS A0A0P7W5K8_9TELE/3-53     AC A0A0P7W5K8.1
#=GS X1WLK6_ACYPI/68-126       AC X1WLK6.1
#=GS H0WCQ4_CAVPO/82-120       AC H0WCQ4.1
#=GS W5NP72_LEPOC/3-107        AC W5NP72.1
#=GS W5PZV0_SHEEP/135-206      AC W5PZV0.1
#=GS G3N174_BOVIN/134-210      AC G3N174.1
#=GS W5LUT2_ASTMX/3-114        AC W5LUT2.1
#=GS H2NB63_PONAB/1-238        AC H2NB63.1
#=GS Q9YI01_DANRE/89-142       AC Q9YI01.1
#=GS G1SBR4_NOMLE/1-213        AC G1SBR4.1
#=GS A0A0P7W5K8_9TELE/75-149   AC A0A0P7W5K8.1
#=GS A0A096P5Y0_PAPAN/143-218  AC A0A096P5Y0.1
#=GS G3N7F8_GASAC/104-153      AC G3N7F8.1
#=GS G3UMP2_LOXAF/3-137        AC G3UMP2.1
#=GS G1SPD8_RABIT/5-219        AC G1SPD8.1
#=GS A0A096P5X9_PAPAN/1-239    AC A0A096P5X9.1
#=GS G5C0A7_HETGA/1-43         AC G5C0A7.1
#=GS G3SG99_GORGO/35-104       AC G3SG99.1
#=GS H0XS45_OTOGA/1-135        AC H0XS45.1
#=GS G3N174_BOVIN/1-137        AC G3N174.1
#=GS H2Q2C6_PANTR/1-214        AC H2Q2C6.1
#=GS A0A088A2C0_APIME/85-149   AC A0A088A2C0.1
#=GS G1KZR6_AILME/3-145        AC G1KZR6.1
#=GS A0A096P5Y0_PAPAN/1-146    AC A0A096P5Y0.1
#=GS E1BNA0_BOVIN/1-234        AC E1BNA0.2
#=GS H2RXZ5_TAKRU/94-160       AC H2RXZ5.1
#=GS M3Z030_MUSPF/1-74         AC M3Z030.1
#=GS Q9YI01_DANRE/3-59         AC Q9YI01.1
#=GS H0WCQ4_CAVPO/115-193      AC H0WCQ4.1
#=GS G1KZR5_AILME/1-108        AC G1KZR5.1
#=GS G3X1T2_SARHA/104-156      AC G3X1T2.1
#=GS G3SG99_GORGO/101-159      AC G3SG99.1
#=GS A0A087YPY6_POEFO/86-138   AC A0A087YPY6.1
#=GS A0A0Q3TKB2_AMAAE/53-178   AC A0A0Q3TKB2.1
#=GS G3TNU2_LOXAF/97-173       AC G3TNU2.1
#=GS W5NP72_LEPOC/113-167      AC W5NP72.1
#=GS E2ACG4_CAMFO/90-148       AC E2ACG4.1
#=GS B7PEY3_IXOSC/74-132       AC B7PEY3.1
#=GS A0A0J7KWF6_LASNI/93-155   AC A0A0J7KWF6.1
#=GS A0A0L7R000_9HYME/94-151   AC A0A0L7R000.1
#=GS M0R5Z2_RAT/137-210        AC M0R5Z2.1
#=GS H0XS45_OTOGA/132-207      AC H0XS45.1
#=GS I3MDQ9_ICTTR/1-236        AC I3MDQ9.1
#=GS FRAT2_MOUSE/1-140         AC Q8K025.1
#=GS H0WCQ4_CAVPO/1-87         AC H0WCQ4.1
#=GS M0R5Z2_RAT/1-140          AC M0R5Z2.1
#=GS A0A0D9SAV0_CHLSB/1-239    AC A0A0D9SAV0.1
#=GS W5LUT2_ASTMX/120-170      AC W5LUT2.1
#=GS FRAT1_MOUSE/1-233         AC P70339.2
#=GS G3INT0_CRIGR/1-111        AC G3INT0.1
#=GS M3Z030_MUSPF/98-172       AC M3Z030.1
#=GS G5C0A7_HETGA/42-92        AC G5C0A7.1
#=GS FRAT2_MOUSE/138-211       AC Q8K025.1
#=GS G1QDF2_MYOLU/86-140       AC G1QDF2.1
#=GS A0A0Q3TKB2_AMAAE/4-59     AC A0A0Q3TKB2.1
#=GS G1QDF2_MYOLU/1-93         AC G1QDF2.1
#=GS A0A0F8AYS3_LARCR/74-166   AC A0A0F8AYS3.1
#=GS G3X1Y7_SARHA/47-175       AC G3X1Y7.1
#=GS M3VZ07_FELCA/1-171        AC M3VZ07.1
#=GS F7GHD6_CALJA/137-214      AC F7GHD6.1
#=GS W5PZV0_SHEEP/1-138        AC W5PZV0.1
#=GS D3Z8R0_RAT/1-233          AC D3Z8R0.1
#=GS L5JPM8_PTEAL/1-75         AC L5JPM8.1
#=GS Q9WVA7_MOUSE/1-232        AC Q9WVA7.1
#=GS G3IHX4_CRIGR/1-104        AC G3IHX4.1
#=GS H2RCJ8_PANTR/1-239        AC H2RCJ8.1
#=GS F7GHD6_CALJA/1-142        AC F7GHD6.1
#=GS L9JG72_TUPCH/1-92         AC L9JG72.1
#=GS H3D2N6_TETNG/3-103        AC H3D2N6.1
#=GS C3YD04_BRAFL/712-771      AC C3YD04.1
#=GS W5J9T1_ANODA/29-106       AC W5J9T1.1
#=GS F7H1S2_MACMU/140-197      AC F7H1S2.1
#=GS G3UMP2_LOXAF/135-193      AC G3UMP2.1
#=GS FRAT1_HUMAN/1-239         AC Q92837.3
#=GS FRAT1_HUMAN/1-239         DR PDB; 1GNG Y; 198-223;
#=GS FRAT1_HUMAN/1-239         DR PDB; 3ZRM X; 199-221;
#=GS FRAT1_HUMAN/1-239         DR PDB; 3ZRK Y; 201-222;
#=GS FRAT1_HUMAN/1-239         DR PDB; 4AFJ Y; 200-222;
#=GS FRAT1_HUMAN/1-239         DR PDB; 1GNG X; 198-223;
#=GS FRAT1_HUMAN/1-239         DR PDB; 3ZRL Y; 201-223;
#=GS FRAT1_HUMAN/1-239         DR PDB; 4AFJ X; 200-222;
#=GS FRAT1_HUMAN/1-239         DR PDB; 3ZRM Y; 201-222;
#=GS FRAT1_HUMAN/1-239         DR PDB; 3ZRK X; 199-222;
#=GS FRAT1_HUMAN/1-239         DR PDB; 3ZRL X; 199-221;
#=GS L5JPM8_PTEAL/71-173       AC L5JPM8.1
#=GS G3TNU2_LOXAF/1-99         AC G3TNU2.1
#=GS H3D2N6_TETNG/106-156      AC H3D2N6.1
#=GS G3SG99_GORGO/1-40         AC G3SG99.1
#=GS H0Y0G4_OTOGA/1-237        AC H0Y0G4.1
#=GS F7H1S2_MACMU/1-142        AC F7H1S2.1
#=GS V4ACG1_LOTGI/20-125       AC V4ACG1.1
#=GS E0VMG3_PEDHC/85-147       AC E0VMG3.1
#=GS G3INT8_CRIGR/1-235        AC G3INT8.1
#=GS A0A084VZQ7_ANOSI/24-110   AC A0A084VZQ7.1
#=GS A0A158NBP1_ATTCE/105-160  AC A0A158NBP1.1
#=GS G3IMA4_CRIGR/83-116       AC G3IMA4.1
#=GS M3Z030_MUSPF/72-99        AC M3Z030.1
E9IBR3_SOLIN/111-165                 ..................................hhhhhyhlkr--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........-----SERSRV..D....DDPY..EVLQEL.LREGGLIKEAVKRLQENLDE-------------lssseade......................................................
G3IMA4_CRIGR/1-85                    ............................................MPSQRAEK.-E.......AGFEAEGE..D..K.-DD..SFLLLQQSVTLSNLT..DVDQLIAKIGETLKLDTA....HD.GPASPSAAP....GPP--PLRV.L...AA.ISVEQNRS.P--------------..-----------------.---------------------...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------l.............................................................
G3T4U3_LOXAF/1-137                   ...........................................a--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..GPAPPGALYSTFGDCGS.VRDWAEPYLVAEFAPGPTALS...LLPPQPGFE..GTPGSGKPGASRQLSGRCRRGWLRG..AAASR..RLRQ.........RLGPRAKGRTS..D....DDSH..RLLQQL.LLSGNLIKEAVRRLRSRRLHLYAKLPQRRLPGP..............................................................
FRAT2_HUMAN/1-214                    ............................................MPCRREEE.EE.......AGEEAEGE..E..E.EDD..SFLLLQQSVTLGSSG..EVDRLVAQIGETLQLDAA....QD.SPASPCAPP....GVPLRAPGP.L...AAaVPADKARP.PAVPLLLPPASAETV..GPAPSGALRCALGDRGR.VRGRAAPYCVAEVAAGPSALP...---------..---------------GPCRRGWLRD..AVTSR..RLQQ.........RRWTQAGARAG..D....DDPH..RLLQQL.VLSGNLIKEAVRRLQRAVAAVAATGPASA----pgp...........................................................
G3X1T2_SARHA/1-98                    ............................................MPCRREEE.DEddetaasGEDDDEGE..G..E.EEE..SFLVLQQSVTVGGSG..DVDRLVAQIGELLRLDAA....HV.SPAAAGGPV....QAHLASRR-.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------rplppsaapapppppp..............................................
F7AUX6_MACMU/1-214                   ............................................MPCRREEE.EE.......AGEEAEGE..E..E.EED..SFLLLQQSVTLGSSG..EVDRLVAQIGETLQLDAA....QD.SPASPCAPP....GAPLRAPGS.L...AAaVPADKARP.PAVPLLLPPASAETV..GPAPPGALRCALGDRGR.VRGRAAPYCVAELAAGPSALP...---------..---------------GPCRRGWLRD..AVTSR..RLQQ.........RRWTQAGARSG..D....DDPH..RLLQQL.VLSGNLIKEAVRRLQRAVAAVAATGPASA----pgp...........................................................
A0A0P7W5K8_9TELE/3-53                .........................................acr--------.--.......--------..-..-.-KE..KYILVEQSVTVDS-K..DVDALVAKIGEALQLH--....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------gggvhggggaqpnsnn..............................................
X1WLK6_ACYPI/68-126                  .........................trpaacescaarrpcrcdd--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........----DDDDDQA..N....DDPY..EMLQAL.LREGSLIKEAVRRLQ------------------iglspkq.......................................................
H0WCQ4_CAVPO/82-120                  ........................................rlpr--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..----VSAVRCALGDRGR.VRGRTAPYGVAELAADPGVLP...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------r.............................................................
W5NP72_LEPOC/3-107                   ..........................................cr--------.--.......--------..-..-.-KE..NYILLEQSVTVDS-K..EVDALVTKIGEALQLHSS....AG.ANSQKTLSS....C-----LHH.S...HS.SSGDKHTC.TSTKHSYSASHTRTS..SNTKHG---CCIRLRNRgLRSRASPYSI-----------...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------pgd...........................................................
W5PZV0_SHEEP/135-206                 ...........................................t--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------LPGPCRRGWLRG..AVTSR..RLQQ.........RRWPPAGARAN..D....DDPH..RLLQQL.VLSGNLIKEAVRRLQRA----------------vpagagtgpra...................................................
G3N174_BOVIN/134-210                 ..........................................st--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------LPGPCRRGWLRG..AVTSR..RLPQ.........RRWPPAGARAN..D....DDPH..RLLQQL.VLSGNLIKEAVRRLQRAVAAVAATGPAG-----pagp..........................................................
W5LUT2_ASTMX/3-114                   ..........................................cr--------.--.......--------..-..-.-KE..NYIFLEQSVTVDS-K..EVDALVTKIGEALQLHNN....SA.GQTMSCL-H....GLGSSSSGG.G...GS.SSSSSSSS.GGGGHGSRQSTGTAG..NPRRGG---CCIRLRSRnLRSRASPYNI-----------...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------pgssdq........................................................
H2NB63_PONAB/1-238                   ............................................MPCRREEE.EE.......AGEEAEGE..E..E.EED..SFLLLQQSVPLGSSG..EVDRLVAQIGETLQLDAA....QH.SPASPCGPP....GAPLRAPGP.L...AA.AVXXXXWTrRSTARPRVRALAETV..GPAPPG-LRCALGDRGR.VRGRAAPYCVAELATGPSALS...PLPPQADLD..GPPGAGKQGIPQPLSGPCRRGWLRG..AAASR..RLQQ.........RRGSQPETRTG..D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLGP..............................................................
Q9YI01_DANRE/89-142                  ...............................gssdqewdhfkss--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........----WNRKKID..E....DDPH..QLLQEL.ILSGNLIKEAVRRLQ------------------fssepsdh......................................................
G1SBR4_NOMLE/1-213                   ............................................MPCRREEE.EE.......AGEEAEGE..E..E.-ED..SFLLLQQSVTLGSSG..EVDRLVAQIGETLQLDAA....QD.SPASPCAPP....GAPLRAPGP.L...AAaVQADKARP.PAVPLLLPPASAETV..GPAPSGALRCALGDRGR.VRGRAAPYCVAEFAAGPSALP...---------..---------------GPCRRGWLRD..AVTSR..RLQQ.........RRWTPAGARAG..D....DDPH..RLLQQL.VLSGNLIKEAVRRLQRAVAAVAATGPASA----pgp...........................................................
A0A0P7W5K8_9TELE/75-149              .....................................ralrsra--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..---------SPYSVPGSSEQDWERV..RTWSR..KGVE.........MSGSGE----E..G....DDPH..RLLQEL.ILSGNLIKEAVRRLQF-----------------saaergeha.....................................................
A0A096P5Y0_PAPAN/143-218             ...........................................a--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------LPGPCRRGWLRD..AVTSR..RLQQ.........RRWTQAGARAG..D....DDPH..RLLQQL.VLSGNLIKEAVRRLQRAVAAVAATGPASAL---gp............................................................
G3N7F8_GASAC/104-153                 .......................................drdwd--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..--QI.........KPWHKKRIEAE..E....DDPH..RLLQEL.ILSGNLIKEAVRRLQF-----------------saaec.........................................................
G3UMP2_LOXAF/3-137                   ...........................grqrrpqssgcpgrgpc--------.--.......--------..-..-.RAD..SFLLLEQPARLGGSA..EVDRLVAQIGEALQLDPA....QD.SPASLCAPP....WQPLQPPLP.L...AE.VPAYRARP.PALPLHLPPSSVEAT..N---LGALYSTFGDCGS.VRDWAEPYLVAEFAPGPTAL-...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------ls............................................................
G1SPD8_RABIT/5-219                   ...........................................r-PQKRKRC.EQ.......ARGRAE--..-..-.RRT..SFLLLEQSVTLGGSG..EVDRLVAQIGETLQLDAA....QD.SPASPCAPP....GRHSSSPRG.L...GA.VRADKAWS.PGVPLLRRLSLAEAV..DGSP-GAVRCALGDRAP.LLRRSAPYCLVRAGRG-----...---------..----FGKQGIPQPLSGPCRRGWLRG..AASSR..RLQQ.........RRGSQPETRTS..D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLRPKLPPCQLPGP..............................................................
A0A096P5X9_PAPAN/1-239               ...........................................r-PCRQHPE.RR.......SSEGSPAS..P..R.PPD..SFLLLQQSVALGSSG..EVDRLVAQIGETLQLDAA....QD.SPASPCAPP....GAPLRAPGP.L...AAaVPADKARP.PAVPLLLPPASAETV..GPAPPGVLRCALGDRGR.VRGRAAPYCVAELATGPSALT...PLPPQADFD..GPPGAGKQGVPQPLSGPCRRGWLRG..AAASR..RLHQ.........RRGSQPETRTG..D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLGP..............................................................
G5C0A7_HETGA/1-43                    ............................................MPCRREEE.EE.......AGEEAEGE..E..E.-EG..SFLLLEQSVTLGGSG..EVDRL-------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------p.............................................................
G3SG99_GORGO/35-104                  .........................................qhl--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.A...AA.VPADKARS.PAVPLLLPPASAETV..GPAPPGVLRCALGDRGR.LRGRAAPYCVAELATGPSALS...PLS------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------..............................................................
H0XS45_OTOGA/1-135                   ............................................MPCGREEE.EE.......AGEEAE-E..E..-.-ED..SFLLLEQSVTLGSSG..EVDRLVAQIGETLQLDAA....QD.SPASPCAPP....GAPLRPP--.-...AA.VPADKAWA.PAVPLLWPPASAEVV..GPALPGTLRCALGDRGR.VRGRAAPYCVAELAAGPSALP...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------g.............................................................
G3N174_BOVIN/1-137                   ............................................MPCRREEE.EE.......AGEEEE--..-..E.EED..SILLLEQSVTVGGSV..EVDRLVAQIGETLQLDAA....QD.RPASACAPP....GPPLQPPRP.P...AA.VRADKARA.PAQPLLLPAVSVEAG..GPAPSGALRCALGDRGR.VRGRAAPYFVAELATGASTLP...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------..............................................................
H2Q2C6_PANTR/1-214                   ............................................MPCRREEE.EE.......AGEEAEGE..E..E.EED..SFLLLQQSVTLGSSG..EVDRLVAQIGETLQLDAA....QH.SPASPCAPP....GVPLRAPGP.L...AAaVPADKARP.PAVPLLLPPASAETV..GPAPSGALRCALGDRGR.VRGRAAPYCVAEVAAGPSALP...---------..---------------GPCRRGWLRD..AVTSR..RLQQ.........RRWTQAGARAG..D....DDPH..RLLQQL.VLSGNLIKEAVRRLQRAVAAVAATGPASA----pgp...........................................................
A0A088A2C0_APIME/85-149              ..............................hhlnhhhhhhhhhh--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........-----KRSTTR..D....DDPY..ELLQEL.LREGGLIKEAVKRLQANLVDLDN----------seeeeddeqss...................................................
G1KZR6_AILME/3-145                   ........................................lftn------QP.EE.......AGEEAEGEaeE..E.EED..SFLLLEQSVTLGGSG..EVDLLVAQIGETLQLDAA....QD.SPASPCAPP....GPPAAGRRR.LpppAT.APRAPARI.PHRRRRPAPAPAAAGalGEPHQGGRAEASFETAA.VTRKASPTPALRASVGPSA--...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------..............................................................
A0A096P5Y0_PAPAN/1-146               ............................................MPCRREEE.EE.......AGEEAEGE..E..E.EED..SFFLLQQSVTLGSSG..EVDRLVAQIGETLQLDAA....QD.SPASPCAPPgappGAPLRAPGP.L...AAaVPADKARP.PAVPLLLPPATAETV..GPAPPGALRCALGDRGR.VRGRAAPYCVAELAAGPSALP...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------g.............................................................
E1BNA0_BOVIN/1-234                   ............................................MPCRREEE.EE.......AGEEEE--..-..-.EED..SFLLLEQSVTVGGSV..EVDRLVAQIGETLQLDAA....QD.RPASACAPP....GPPLQPPRS.P...AA.VRADKARA.PAQPLLLPAASIEAG..GPAPLGALRCALGDRGR.VRGRAAPYFVAELAAGPTALS...PLPPQPSLD..GPLGADKRGSPQPLSGPCRRGWLRD..AAASR..RLQH.........RRGLQPPARNG..D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLHAKLPQRQLLGP..............................................................
H2RXZ5_TAKRU/94-160                  ...................rraspynipgssgeqdwdrikqwng--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........-----KTMAAE..E....EDPH..RLLQEL.ILSGNLIKEAVRRLQF-----------------saadcaefp.....................................................
M3Z030_MUSPF/1-74                    ............................................MPCRREEE.EE.......AGEEAEGEaeE..E.EED..SFLLLEQSVTLGGSG..EVDLLVAQIGETLQLDAA....QD.SPASPCAPP....GPPL-----.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------g.............................................................
Q9YI01_DANRE/3-59                    ..........................................cr--------.--.......--------..-..-.-KE..NYIFLEQSVTVDS-K..EVDALVSKIGEALQLHNN....SS.SQKA-----....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------msrlhgftgskpngg...............................................
H0WCQ4_CAVPO/115-193                 .........................................pgv--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------LPRPCRREWLQG..SVASR..RLQQ.........RRWTHAAARAG.sD....DDPH..RLLQQL.VLSGNLIKEAVRRLQRAVAAVAATSP-------vgtpgp........................................................
G1KZR5_AILME/1-108                   ............................................--------.-E.......AGEEAEGEaeE..E.EED..SFLLLEQSVTLGGSG..EVDLLVAQIGETLQLDAA....QD.SPASPCAPP....GPPAAAPGHtK...SA.SKMLYGKP.QLARMDLPPSSATTR..-----------------.---------------------...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------lffpgglcsign..................................................
G3X1T2_SARHA/104-156                 ........................................aphr--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........---GQPGLRAG..G....NDSH..RLLQQL.LLSGDLIKEAVRRLQRAVAAVT-----------gagssatp......................................................
G3SG99_GORGO/101-159                 ...........................................s--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..------------PLSGPCRRGWLRG..AAASR..RLQQ.........RRGSQPETRTG..D....DDPH..RLLQQL.VLSGNLIKEAVRRL-------------------..............................................................
A0A087YPY6_POEFO/86-138              .............................aepdwdqirpwnrkr--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........-----VPVRVQ..E....EDPH..RLLQEL.ILSGNLIKEAVRRLQ------------------fspdcr........................................................
A0A0Q3TKB2_AMAAE/53-178              .......................................hlgpg--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..----------------S.ARDRAAPYSP-RCSGGGGLLAprgPLPPQAHQQpaEPPRPDRSGHQRVTKQLCGRGWLRS..AAR-R..RKQP.........LPGP-GDGPAD..E....EDPH..RLLQQL.ILSGNLIKEAVRRLQLAAVAAAA----------aasttssgs.....................................................
G3TNU2_LOXAF/97-173                  ...........................................a--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------LPGPCRRGWLRG..AATAN..RLQQ.........RRWPQAGTRAG..N....DGSHddRLLQQL.VLSGNLIKEAVRRLQRAVAAA------------aavagglsgp....................................................
W5NP72_LEPOC/113-167                 ..................................wdslrawnrk--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........----KIDVSSQ..E....DDPH..QLLQEL.ILSGNLIKEAVRRLQLS----------------tadradlckp....................................................
E2ACG4_CAMFO/90-148                  ...........................qnhvtaghhhhyhshlk--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........----RTERNRV..D....DDPY..EVLQEL.LREGGLIKEAVKRLQAN----------------ldefsss.......................................................
B7PEY3_IXOSC/74-132                  ...................................vsavpkdvv--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........RRTCANHHQDA..D....KDPY..EMLQDL.LRQGTLIQEAVRRLQENVV--------------gktkaphsl.....................................................
A0A0J7KWF6_LASNI/93-155              ............................nqvtaghhhhyhshlk--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........----RTERNRV..D....DDPY..EMLQEL.LREGGLIKEAVKRLQANLDEL------------sssevded......................................................
A0A0L7R000_9HYME/94-151              ..................................hhhlhhhlhh--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........---SHKRNANR..D....DDPY..ELLQEL.LREGGLIKEAVKRLQAN----------------ldvldnseeedd..................................................
M0R5Z2_RAT/137-210                   ..........................................lp--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..---------------RPGRRGWLPG..ALASR..RIQQ.........RRCTASGSRAA..D....DDPH..RLLQQL.VLSGNLIKEAVRRLQRAVAAVAATSPAS-----apg...........................................................
H0XS45_OTOGA/132-207                 ...........................................a--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------LPGPCRRGWLRG..AVASR..RLPQ.........RRWTQTGAHAG..D....DDPH..RLLQQL.VVSGNLIKEAVRRLQRAVAAVAATGPV------gtpgp.........................................................
I3MDQ9_ICTTR/1-236                   ............................................MPCRREEE.EE.......AGEEAEGE..E..EdDDD..SFLLLKQSVTLEGSG..EVDRLVAQIGQTLQLDAA....HD.SPASRCVPP....GPPLQPP--.-...VA.LPADKARS.PAVPLLLRPVSAEAG..GLAPPGALRCALGDRGR.VRGRAAPYCVAELSSGPSALS...PLSSQPGLD..GPPGAGKQGIPQPLTGPCRRGWLRS..AAASR..RLQQ.........RRGSQPDTCTG..D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLHAKLPQHRLLGP..............................................................
FRAT2_MOUSE/1-140                    ............................................MPCRREEE.EE.......AGDEAEGE..E..D.-DD..SFLLLQQSVTLGGST..DVDRLIVQIGETLQLDTA....HD.RPASPCAAP....GPPPAPPRV.L...AA.LSADKTGT.PARRLLRPTGSAETG..DPAPPGAVRCVLGERGR.VRGRSAPYCVAEIAPGASALP...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------g.............................................................
H0WCQ4_CAVPO/1-87                    ...........................................q----RAGK.EE.......EDREVQGW..SrvE.EDQ..SFLLLEQTVTLGGSG..EVDRLG----GPDRQDAAvwtrHPtARPSPGAPP....GPPLQPPRP.P...AA.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------slrlprvs......................................................
M0R5Z2_RAT/1-140                     ............................................MPCRREEEeEE.......AGDEAEGE..E..D.-DD..SFLLLQQSVTLGGST..DVDRLIAQIGETLQLDAA....HD.SPASPCAAP....GPPP-APPV.L...AA.LPADKVGG.PAR-LLRPAASAEAG..DPAPPGAVRCVLGERGR.VRGRAAPYCVAEIAPGASALP...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------rp............................................................
A0A0D9SAV0_CHLSB/1-239               ............................................MPCRREEE.EE.......AGEEAEGE..E..E.EED..SFLLLQQSVALGSSG..EVDRLVAQIAETLQLDAA....QD.SPASPCAPP....GAPLRVPGP.L...AAaVPADKARP.PAVPLLLPPASAETV..GPAPPGVLRCALGDRGR.VRGRAAPYCVAELATGPSALS...PLPPQADFD..GPPGAGKQGVPQPLSGPCRRGWLRG..AAASR..RLQQ.........RRGSQPETRTG..D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLRAKLPQRPLQGP..............................................................
W5LUT2_ASTMX/120-170                 ........................................ktwn--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........-RGKGLDVTGS..E....DDPH..QLLQEL.ILSGNLIKEAVRRLQY-----------------sadsehdlak....................................................
FRAT1_MOUSE/1-233                    ............................................MPCRREEE.EE.......AGDEAEGE..E..D.-DD..SFLLLQQSVTLGGST..DVDQLIVQIGETLQLDAA....HD.RPASPCAAP....GPP--PPQV.L...AA.LPADKTGT.PARRLLRPTGSAETG..NPAPPGAVRCVLGERGR.VRGRSAPYCVAEISPGASAL-...--PQQPGLD..GPPGTGKLSTPQPLSGPCRRGWLRN..AAASR..RLQQ.........RRGSQPETRTG.dD....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRQLQLHAKLPAHPFLGP..............................................................
G3INT0_CRIGR/1-111                   ............................................--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..----------MLWEPRR.LQSRAAPYCMVELTPDASALC...PVSQQPGLE..GPPVTGKPSTLQPLSGPCWRGWPQS..TAMSR..LLQQ.........RCGSQPDTHTS..D....EDPH..QLLQQL.LLSGNLIKEAVQ---------------------apivlv........................................................
M3Z030_MUSPF/98-172                  ............................................--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------LPGPCRRGWLRG..AASSR..RLQQ.........RRWPPAGTRAR..D....DDPH..RLLQQL.VLSGNLIKEAVRRLQRAVAAVAATSPA------gasgp.........................................................
G5C0A7_HETGA/42-92                   ...........................................l--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........-----PEPRAG..D....DDPH..RLLQQL.VLSGNLIKEAVRRLHARRLQLQAKLPQGPLLGP..............................................................
FRAT2_MOUSE/138-211                  ............................................--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------LPGPGRRGWLPG..SVASH..RIQQ.........RRWTAGGARAA..D....DDPH..RLLQQL.VLSGNLIKEAVRRLQRAVAAVAATSPAS-----apg...........................................................
G1QDF2_MYOLU/86-140                  ........................................karp--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........-----PDXRTG..D....DDPH..RLLQQLgALPGTSSRKACGGFHSRRLQLHAKLPQRPLLRP..............................................................
A0A0Q3TKB2_AMAAE/4-59                .........................................rpg--------.--.......--------..-..-.--E..RFLLLERSVAVGQAGpkEVDALVAKLGEVLQLSAQ....RA.PP-------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------pprnpkhlgpgsa.................................................
G1QDF2_MYOLU/1-93                    ........................................vpgg----KEEK.GK.......PGRKRRGE..E..R.REDqgNFLLLERSVTLGGSG..EVDRLVAQIGETLQLDAG....QD.SPASLCAPP....GPPLQPPRP.P...AA.VLADKARP.PD-------------..-----------------.---------------------...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------xr............................................................
A0A0F8AYS3_LARCR/74-166              ggcaaapaqkrngccmrlrsrghrgssraspynipgsngdqdwd--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..--QI.........KPWNKKRVDVE..E....DDPH..RLLQDL.ILSGNLIKEAVRRLQF-----------------saadcadfp.....................................................
G3X1Y7_SARHA/47-175                  .................vgavaplpsrvqsspcvpggapgrsst--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..SAPHICKRGLPQPLAGPCRRTWLRG..AAASR..RLQQqhhhqhpqyRYRGQPGLRAG..E....DDPH..QLLQQL.VLSGNLIKEAVRRLHSRRPRL------------ylgaraplpqepsppp..............................................
M3VZ07_FELCA/1-171                   ...........................................g--------.--.......--------..-..-.---..---------------..------------------....--.---------....-PAATSPIV.Y...KS.TRAGRIPA.PAAAGALPPAPAEAV..GPAPPGALRCALGDRGR.VRGRAAPYFVAELAAGPSALS...PLAPHPGFD..GPSGANKRGAPQPLSGPCRRGWLRG..AAASR..RLQQ.........RRGTQLESRTG..D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLHAKLPQRPLTGP..............................................................
F7GHD6_CALJA/137-214                 ............................................--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..----------PSTLPGPCRRGWLRD..AVTSR..RLQQ.........RRWTQAGARAG..D....DDPH..RLLQQL.VLSGNLIKEAVRRLQRAVAAVAATSPASA----agp...........................................................
W5PZV0_SHEEP/1-138                   ............................................MPCRREEE.EE.......AGEEEE--..-..E.EED..SFLLLEQSVTVGGSV..EVDRLVAQIGETLQLDAA....QD.RPASACAPP....GPPLQPPRP.P...AA.VRADKARA.PAQPLLLPAASVEAG..GPAPPGALRCALGDRGR.VRGRAAPYFVAELAAGASTLP...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------g.............................................................
D3Z8R0_RAT/1-233                     ............................................MPCLREE-.EE.......ASDQADGE..E..D.-ND..SFLLLQQSVTLGGSA..DVDQLIARIGETLQLDTA....HD.SPASQCAAP....GPPPAPPRV.L...AA.LPADKARA.PTRRLLRLAASPETW..DPAPPGAMRCVLGERGR.VRDRAAPYSVAEIAPGPSVL-...--PQQQGLE..GPQGTGKLSIPQPLSGPCRRGWLRN..TAASR..RLQQ.........RRGSHLETRTG..E....DDPP..RLLQQL.LLSGNLIKEAVRRLHSRRLQLQAKLPAHPFLEP..............................................................
L5JPM8_PTEAL/1-75                    ............................................MPCRREEE.EE.......AGEEAEGE..E..E.EED..SFFLLEQSVTLGSSG..EVDRLVAQISETLQLDGA....QD.SPASPCAPS....GPPLHAL--.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------s.............................................................
Q9WVA7_MOUSE/1-232                   ............................................MPCRRE--.EE.......AGDEAEGE..E..D.-DN..SFLLLQQSVTLGGSA..DVDRLIAQIGETLQLDAR....HD.GPASPCAAP....GPPPAPPRV.L...AA.LPADKAGA.PARRLLRRAASAEAG..DPAPPGAVRCVLGERGR.LRGRAAPYCVAEIAPGASAL-...--PQQLGLE..VSPGMGKVSIPQPLSGRCRRGWLRN..AAASR..RQQQ.........RRGSQSETRTS..D....GDPP..RLLQQL.LLSGNLIKEAVRRLHSRGLQLQAKLPAHSFLGP..............................................................
G3IHX4_CRIGR/1-104                   ............................................MPCQSAEK.-E.......AGFETEGE..D..K.-DD..SFLLLQQSVTLGSLT..DVDQLIAKIGETLKQIFC....VC.RDRGPSSPW....SHSLH----.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------avrtgacgagqlptvwqssprapasyplcpcsla............................
H2RCJ8_PANTR/1-239                   ............................................MPCRREEE.EE.......AGEEAEGE..E..E.EED..SFLLLQQSVALGSSG..EVDRLVAQIGETLQLDAA....QH.SPASPCGPP....GALLRAPGP.L...AAaVPADKARS.PAVPLLLPPASAETV..GPAPPGVLRCALGDRGR.VRGRAAPYCVAELATGPGALS...PLPPQADLD..GPPGAGKQGIPQPLSGPCRRGWLRG..AAASR..RLQQ.........RRGSQPETRTG..D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLGP..............................................................
F7GHD6_CALJA/1-142                   ............................................MPCRREEE.EE.......AIEEAEGE..E..E.EED..SFLLLEQSVTLGSSG..EVDRLVAQIGETLQLDAA....QD.SPASPCAPP....RAPLRAPGP.L...AAaVPADKARP.LAVPLLLPSASAETV..GPAPHGALRCALGDRGR.VRGRAAPYCVAELAAGPSTLP...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------g.............................................................
L9JG72_TUPCH/1-92                    ............................................MPCRREEEeEE.......AGEEAEGE..E..EvEED..SFLLLEQAVTLGGSG..EVDRL-ALIT--------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------qchpadslmekeemslglaeagcgcprkavsrlqrlrvhldaw...................
H3D2N6_TETNG/3-103                   ..........................................cr--------.--.......--------..-..-.-KE..NYILLEQSVTVGS-K..EVDALVTRIGEALQLHNN....GG.G--------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------hqktvavsvsclhgrggggsagvrqasssapasaqrrggclmrlrsrphrwssraspysvpg
C3YD04_BRAFL/712-771                 ...........................anksgavckkspprnar--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........-RLLQ--RRCD..S....EDPY..AMLQEL.LRSGNLIKEAVKRLGSR----------------getgrtr.......................................................
W5J9T1_ANODA/29-106                  .....................................pshqptr--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------SSRPSPYHIPCR-SWSEP..VCGGV..GVGA.........EKKIVGKAKTK..DeqtiDDPY..EFLQTL.LKNNNLVKEAVRRLQ------------------hgls..........................................................
F7H1S2_MACMU/140-197                 ...........................................l--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------LSGPCRRGWLRG..AAASR..RLQQ.........RRGSQPETRTG..D....DDPH..RLLQQL.VLSGNLIKEAVRRL-------------------..............................................................
G3UMP2_LOXAF/135-193                 ...........................................l--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------LSGRCRRGWLRG..AAASR..RLRQ.........RLGPRAKGRTS..D....DDSH..RLLQQL.LLSGNLIKEAVRRLR------------------..............................................................
FRAT1_HUMAN/1-239                    ............................................MPCRREEE.EE.......AGEEAEGE..E..E.EED..SFLLLQQSVALGSSG..EVDRLVAQIGETLQLDAA....QH.SPASPCGPP....GAPLRAPGP.L...AAaVPADKARS.PAVPLLLPPALAETV..GPAPPGVLRCALGDRGR.VRGRAAPYCVAELATGPSALS...PLPPQADLD..GPPGAGKQGIPQPLSGPCRRGWLRG..AAASR..RLQQ.........RRGSQPETRTG..D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLGP..............................................................
#=GR FRAT1_HUMAN/1-239         SS    ............................................XXXXXXXX.XX.......XXXXXXXX..X..X.XXX..XXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXX....XX.XXXXXXXXX....XXXXXXXXX.X...XXXXXXXXXXX.XXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXX...XXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXX..XXXXX..XXXX.........XXXXXXXXXXX..X....XXHH..HHHHHH.HHTT-HHHHHHHHHHXXXXXXXXXXXXXXXXXX..............................................................
L5JPM8_PTEAL/71-173                  ..........................................lh--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.------------------ALS...PLPPQPGLD..GAPEAFKRGAPQSLSGPCRRGWLRG..AAGSR..RLQQ.........RRGPQPEVRTG..D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLHAKLPQRPLLRP..............................................................
G3TNU2_LOXAF/1-99                    ...........................................x--------.--.......--------..-..-.---..-----EQSVTLGGSG..EVDRLVAQIGEALQLDAA....QD.SPASPCAE-....---------.-...--.VPADKARP.PALPLLLSPAPASAE..A-AGPGALRCTLGDRGR.VRGRAAPYCVAELTAGPSALP...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------..............................................................
H3D2N6_TETNG/106-156                 ......................................gdrdwd--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..--QI.........RQWKRKAMAVE..E....DDPH..RLLQEL.ILSGNLIKEAVRRLQL-----------------saadc.........................................................
G3SG99_GORGO/1-40                    ............................................--------.--.......--------..-..-.--D..SFLLLQQSVALGSSG..EVDRLVAQIGETLQLDAA....QH.LAA------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------a.............................................................
H0Y0G4_OTOGA/1-237                   ............................................MPCRREEE.EE.......AGEEAEGE..E..E.-KD..SFLLLEQSVTLGSSG..EVDKLVAQIGETLQLDAA....QD.SPASPCASL....GAPLRAPRP.Q...AA.VRADEGPA.AAVQLLLPPSSSEGV..GPAPPGALRCALGDRGR.VRGRAAPYCVAELVAGPSALP...TLPLQPGQD..GPLGAGKRGVSQQLSGPCRRGWLRG..AAASR..RLQQ.........RRGSQPETRTN..D....DDPH..RLLQQL.VLSGNLIKEAVRRLHSRRLQLHTKLPQRPLLGP..............................................................
F7H1S2_MACMU/1-142                   ............................................MPCRREEE.EE.......AGEEAEGE..E..E.EED..SFLLLQQSVALGSSG..EVDRLVAQIGETLQLDAA....QD.SPASPCAPP....GAPLRAPGP.L...AAaVPADKARP.PAVPLLLPPASAETV..GPAPPGVLRCALGDRGR.VRGRAAPYCVAELATGPSAL-...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------ls............................................................
V4ACG1_LOTGI/20-125                  .............idnlvkgirdrlclksqeklskyrstpysii--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..--------------RSPCRENGGSGlcQKCSC..KRNN.........WRSCCCKVKEE..D....ESPH..KLLEKL.LHEQTLIQEAVRRLTSRM---------------esansamsvpmts.................................................
E0VMG3_PEDHC/85-147                  .....................clkattrhcgghscltinnktlk--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........----TKSNVTS..A....DDPY..EMLQEL.LRDGSLIKEAVRRLE------------------mglspkq.......................................................
G3INT8_CRIGR/1-235                   ............................................MQCQRAEK.EE.......GGFEAEGE..D..K.-DD..SFLLLQQSVTLGSLT..DVDQLIALIGETLKLDTA....HD.GPASPSAAP....GPP--PLRV.L...AA.ISVEQNRS.PSRQMLRSSVPAETG..APAHPRAISCMLWERWR.LRSQAAPYCVAELTAVTSALC...PVSRQPGLE..GPPVTGKPSTPQPLSGPCRRGWPQS..TAMSL..PLQQ.........RPGSQPETHTS..D....DDPH..QLPQQL.LLSGNLIKEAVQRLHSLQLQLQANLYSHRFLK-r.............................................................
A0A084VZQ7_ANOSI/24-110              ..................................rlkakpshqs--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-----SRSSRPSPYHIPCR-SWSEP..LCGNGtdKGKL.........SSGCKAKTKGDetI....DDPY..EFLQTL.LKNNNLVKEAVRRLQH-----------------glspkqr.......................................................
A0A158NBP1_ATTCE/105-160             .................................hhhhyhnhlkr--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........------SERRV..D....DDPY..EVLQEL.LREGGLIKEAVKRLQENLDEL------------sssevden......................................................
G3IMA4_CRIGR/83-116                  ..........................................sp--------.--.......--------..-..-.---..---------------..----LIAKIGETLKLDTA....HD.GPASQSAAQ....---------.-...--.--------.---------------..-----------------.---------------------...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------vtgigae.......................................................
M3Z030_MUSPF/72-99                   ...........................................p--------.--.......--------..-..-.---..---------------..------------------....--.---------....---------.-...--.--------.---------------..-----------LGDRGR.VRGRAAPYFVAELAAGPSALP...---------..-------------------------..-----..----.........-----------..-....----..------.---------------------------------..............................................................
#=GC SS_cons                         ............................................XXXXXXXX.XX.......XXXXXXXX..X..X.XXX..XXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXX....XX.XXXXXXXXX....XXXXXXXXX.X...XXXXXXXXXXX.XXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXX...XXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXX..XXXXX..XXXX.........XXXXXXXXXXX..X....XXHH..HHHHHH.HHTT-HHHHHHHHHHXXXXXXXXXXXXXXXXXX..............................................................
#=GC seq_cons                        ..............................................................................................................................................................................................................................................................................................t.ttt..p....-DPa..phLQpL.lhpGsLIKEAV+RLp................................................................................
//
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