GenomeNet

Database: Pfam
Entry: Gemini_AL1
LinkDB: Gemini_AL1
Original site: Gemini_AL1 
#=GF ID   Gemini_AL1
#=GF AC   PF00799.19
#=GF DE   Geminivirus Rep catalytic domain
#=GF PI   Geminivirus_AL1;
#=GF AU   Bateman A
#=GF SE   Pfam-B_286 (release 2.1)
#=GF GA   21.10 21.10;
#=GF TC   21.10 21.20;
#=GF NC   21.00 20.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   12130667
#=GF RT   The structure of a replication initiator unites diverse aspects
#=GF RT   of nucleic acid metabolism. 
#=GF RA   Campos-Olivas R, Louis JM, Clerot D, Gronenborn B, Gronenborn
#=GF RA   AM; 
#=GF RL   Proc Natl Acad Sci U S A 2002;99:10310-10315.
#=GF DR   INTERPRO; IPR022690;
#=GF DR   SCOP; 1l2m; fa;
#=GF CC   The AL1 proteins encodes the replication initiator protein (Rep)
#=GF CC   of geminiviruses, which is a replicon-specific initiator enzyme
#=GF CC   and is an essential component of the replisome [1]. For
#=GF CC   geminivirus Rep protein, this N-terminal region is crucial for
#=GF CC   origin recognition and DNA cleavage and nucleotidyl transfer
#=GF CC   [1].
#=GF SQ   35
#=GS REPA_MSVS/10-117         AC P14990.1
#=GS A2QYZ7_ASPNC/35-149      AC A2QYZ7.1
#=GS A0A0C3MVJ8_PISTI/31-112  AC A0A0C3MVJ8.1
#=GS F8PXP0_SERL3/56-159      AC F8PXP0.1
#=GS U9TNC2_RHIID/1-84        AC U9TNC2.1
#=GS REP_BCTVC/7-119          AC P14991.2
#=GS A0A0F7ZR17_9HYPO/72-161  AC A0A0F7ZR17.1
#=GS A0A139JQ57_9MOLU/39-160  AC A0A139JQ57.1
#=GS A0A0C9YD25_9AGAR/71-177  AC A0A0C9YD25.1
#=GS REP_TPCTV/8-120          AC Q88888.1
#=GS B1P3D8_BCTIV/18-133      AC B1P3D8.1
#=GS U9TRZ4_RHIID/23-135      AC U9TRZ4.1
#=GS A0A139JQ75_9MOLU/26-155  AC A0A139JQ75.1
#=GS REPE_ONYPE/11-144        AC P60470.1
#=GS F8Q706_SERL3/97-200      AC F8Q706.1
#=GS C3UV60_ECSVG/8-116       AC C3UV60.1
#=GS A0A0A2I3L7_PENEN/41-109  AC A0A0A2I3L7.1
#=GS REP_BGYMJ/7-119          AC P0CK40.1
#=GS A0A0F7ZQL9_9HYPO/36-165  AC A0A0F7ZQL9.1
#=GS L7FL16_ENTIV/92-138      AC L7FL16.1
#=GS X6MQ48_RETFI/202-306     AC X6MQ48.1
#=GS A0A0F7ZIQ0_9HYPO/36-169  AC A0A0F7ZIQ0.1
#=GS U2CM30_9FIRM/1-42        AC U2CM30.1
#=GS A0A139JPY3_9MOLU/35-160  AC A0A139JPY3.1
#=GS L7FL16_ENTIV/41-97       AC L7FL16.1
#=GS A0A0M9E761_9DELT/4-111   AC A0A0M9E761.1
#=GS REP_TYLCI/5-117          AC P27259.1
#=GS A0A0D1YMS2_9EURO/45-153  AC A0A0D1YMS2.1
#=GS L7FKJ3_ENTIV/30-142      AC L7FKJ3.1
#=GS A0A100I8I6_ASPNG/37-127  AC A0A100I8I6.1
#=GS A0A0F7ZVZ6_9HYPO/16-143  AC A0A0F7ZVZ6.1
#=GS REP_MSVS/10-117          AC P14989.2
#=GS D8WZ30_TCTVB/8-120       AC D8WZ30.1
#=GS A0A0F8A0B9_9HYPO/36-165  AC A0A0F8A0B9.1
#=GS L7FMK9_ENTIV/38-151      AC L7FMK9.1
REPA_MSVS/10-117                    ..............FSHRNANTFLTYPKC.P.E.N.PEI.ACQMI.....-WELV.....V....R........W..IP..K...YIL.....CAREAHK......D.GSLHLHALLQTEK..PVRIS.D.SR..FFD.ING-----.............-FHPNIQ.......SA.KSVNR.V...RDYILKE.PLA.VfERGTFI--pr.....................................................
A2QYZ7_ASPNC/35-149                 ............kk--IHRRWIFLTYTEC.P.L.E.HEVdFVEGL.....RAMLK.....Q....N........SlaSD..R...FYG.....CCQEY-T......Q.KGIVYHVLLHLGK..QVNWK.A.--..---.--------.............-------.......--.-----.-...-------.---.-.--------sharrvllvsnsphesiniltprpgqvgnfieshvkycekvandnc.........
A0A0C3MVJ8_PISTI/31-112             frwsakryfltpst---------------.-.-.-.---.-----.....-----.....-....-........-..--..-...-WK.....AAVESHQ......D.GGKHWHVIVQFDQ..AIRSR.R.AD..LFD.IDG-----.............-LHPNVV.......TL.KSHRD.LltrWEYIHKE.---.-.--------egaevfg................................................
F8PXP0_SERL3/56-159                 ..............FRWSARNMLLTYSQI.G.D.R.PNQ.ALSDV.....IAQLS.....L....Q........L..AE..-...-WA.....AIREHHQ......D.GGSHWHVIVKFDV..PIRSR.N.PA..FFD.VDG-----.............-IHPNVKt....laSA.KSVCN.A...WTYLQKE.E--.-.--------gadhfg.................................................
U9TNC2_RHIID/1-84                   ...........mpg---------------.-.-.-.--R.IIELL.....RFKLD.....N....R........R..NA..I...VISg..fsAGREAHQ......E.GGFHTHILMKFEK..KINVN.D.AN..FMD.VEDED---.............-------.......--.-----.-...-------.---.-.--------wsiipilrrykilklceervs..................................
REP_BCTVC/7-119                     ..............FRIQAKNIFLTYPQC.S.L.S.KEE.ALEQI.....-QGIQ.....L....S........S..NK..K...YIK.....IARELHE......D.GQPHLHVLLQLEG..KVQIT.N.IR..LFD.LVSPTRSA.............HFHPNIQ.......GA.KSSSD.V...KSYVDKD.GDT.I.EWGEFQID.......................................................
A0A0F7ZR17_9HYPO/72-161             .......giveifg---------------.-.-.-.---.-----.....-----.....-....-........-..--..-...---.....-SLERHE......D.GTPHYHVVMKFEP..RVHWR.N.ARekFFV.YRDVDGQRevdt....esvhiRKKPNKE.......RAeKFLAD.V...QAYVQKD.GVV.F.--------gkwisa.................................................
A0A139JQ57_9MOLU/39-160             ..............FFVQGKNIGFTYDYC.P.L.K.HFE.IVSQI.....KDKIA.....Ly..aK........Q..IK..K...LIViksilFSNETHQ......D.GSLHSHGFLQLNR..KLRIR.K.GR.aFFR.LQD-NHNH.............FYNPSLT......tTF.PDTTDnW...YNYILKK.DDI.Y.SEGK----ycp....................................................
A0A0C9YD25_9AGAR/71-177             ..............FRLRAKKFLLTYSQVgD.L.D.VSE.AQMML.....-ASLP.....H....P........-..-P..V...QWA.....GVVEKHV......D.DHFHWHIICIFDKipNVRFRsA.SR..VFD.IHH-----.............-LHPNIRl....lpGE.RDIKR.A...WDYIHKD.PL-.-.--------sdrfg..................................................
REP_TPCTV/8-120                     ..............FQIAAKNYFLTYPNC.S.L.S.KEE.ALDQL.....-QRLQ.....T....P........T..NK..K...YIK.....VARELHE......N.GEPHLHVLIQFEG..KFNCK.N.QR..FFD.LVSPTRST.............HFHPNIQ.......GA.KSSSD.V...NSYVDKD.GDT.I.EWGEFQID.......................................................
B1P3D8_BCTIV/18-133                 .............l-RFQKKNAFLTYSQI.GgD.F.KDY.IFEKL.....-KTLL.....E....S........Y..VI..L...SLA.....VSLEHHQpteeqpE.GGFHTHCIIQCDK..KLDVN.G.NL..FFN.IILPDGRT.............-IHPRID.......GL.NAPKR.A...FEYITKE.D--.-.--------tsprtfge...............................................
U9TRZ4_RHIID/23-135                 ..............FSIIAKIIFFTYSRC.P.L.T.PSY.CIESL.....RSKLS.....S....R........R..SP..I...GIIg..ysVGLEHLT......D.GGLHIHVLIKLDK..KIDLR.D.GR..FFD.IVDGDGET.............VYHPSVE.......EC.KNFNA.A...RDYIRKE.---.-.YKENL---dag....................................................
A0A139JQ75_9MOLU/26-155             .............y-RLKTKMVGLTYSRF.P.V.L.KEK.FIQLL.....KEKIN.....LfnskN........K..NK..I...NVIy..diSCNDYHM......D.SGLHIHALLVFDK..KIQLR.DaQK..VFA.LPFINYQGkeey.....rtacFEKPKQK.......FG.NHLDR.F...RAYIIKK.GNF.I.ENGI----ypkk...................................................
REPE_ONYPE/11-144                   ............tm--FQAQNIFLTYSQC.D.L.S.KEE.IKTFIinlcnEKKLQ.....I....N........-..--..-...YLI.....IGIENHQ......DhKGKHHHVFFQLNK..QFRTR.D.LT..IFN.IPKNIKEKklidhenikikdfFYSPHIEpr..pgnPI.KDTTD.V...RNYVKKD.GDF.I.EEGTFK--hv.....................................................
F8Q706_SERL3/97-200                 ..............FRWSARNMLLTYSQI.G.D.R.PNQ.ALSDA.....IARLS.....P....Q........-..-P..A...EWA.....AVREHHQ......D.GGSHWHVIVKFDV..PIRSR.N.PA..FFD.VDG-----.............-IHPNVKm....laSA.KSVRD.A...WTYLQKE.E--.-.--------gadhfg.................................................
C3UV60_ECSVG/8-116                  ..............FRIQGKAFFLTYSQC.P.R.E.PKD.VGEFL.....TSHST.....L....A........S..HV..V...YVR.....VQQEKHQ......D.GNNHLHAIVCTSE..RRDIR.D.PR..IFD.FGE-----.............-FHPKIE.......TC.RSVSK.S...LKYIQKEaGSF.Y.EHGT----vpcd...................................................
A0A0A2I3L7_PENEN/41-109             ...........rfr----HRWVFLTYARC.S.LeS.KDD.FEEGF.....SDMLN.....R....N........G..FR..Q...ATY....yGCREHHK......F.EGIHYHVLVNLGK..Q----.-.--..---.--------.............-------.......--.-----.-...-------.---.-.--------pnwsyd.................................................
REP_BGYMJ/7-119                     ..............FRVQSKNYFLTYPRC.T.I.P.KEE.ALSQL.....-QKIH.....T....T........T..NK..K...FIK.....VCEERHD......N.GEPHLHALIQFEG..KFICT.N.KR..LFD.LVSTTRSA.............HFHPNIQ.......GA.KSSSD.V...KEYIDKD.GVT.I.EWGQFQVD.......................................................
A0A0F7ZQL9_9HYPO/36-165             ..............FVLQSRLVFVTYSRS.R.V.SdKEE.FHKYL.....KDSLE.....P....NlpyvgaeeR..AT..V...EIF.....GSKELHE......D.DAPHYHVVLRFSK..KVHWR.Q.ARqkLAV.WIEVDGERvid.......thsI---YIRrkkpgepHE.KWLQD.V...QGYVAKD.GDV.-.--------fgsw...................................................
L7FL16_ENTIV/92-138                 .....klpkywgis---------------.-.-.-.---.-----.....-----.....-....-........-..--..-...---.....-------......-.-------------..-----.-.--..---.----SRRK.............KYHGHYE.......KV.DSSVN.V...MKYVKKD.GDW.I.EEGT----apve...................................................
X6MQ48_RETFI/202-306                ..............FRLQAKNLFLTYPQC.T.L.Q.PEE.ALAIL.....ETKLQ.....I....N........-..--..E...Y-L.....IAVENHI......Q.KGRHLHCYINCKK..KVDIR.S.AH..RLD.LDG-----.............-FHGNYQ.......GC.RSLTA.V...KKYCTKE.KNY.I.T-------niynfait...............................................
A0A0F7ZIQ0_9HYPO/36-169             ..............FKLNAKMAFVTYSRS.Q.M.DdKEE.FFKCL.....KESLAdslprV....S........A..TK..KvavEIF.....GSKEVHQ......D.GTPHYHVVLRFSK..KIHFR.K.ARekLFVwIIK-DGQRvvdt....esiyiRKKPAWE......sPS.KFLQD.V...QAYVAKD.GDV.F.--------gewigtq................................................
U2CM30_9FIRM/1-42                   ............ma---------------.-.-.-.---.-----.....-----.....-....-........-..--..-...---.....-------......-.-------------..-----.-.--..--N.INNNKKPA.............FYTPSTH.......HV.KSH-Y.V...RSYIKRD.GTF.V.K-------aswrd..................................................
A0A139JPY3_9MOLU/35-160             .............y-RMHSRNIGFTYPNL.S.L.S.KEE.VQKIFiq.kfIKESR.....K....R........K..KK..I...YYKa..lrISRELHE......D.GEPHIHILIQLNK..KTEFC.N.AR.eFFA.LPTFNKN-.............-------.......--.-----.-...-------.---.-.--------nelemkycsferyfaqstpehwyryigaygdvlddgifk................
L7FL16_ENTIV/41-97                  ..............FRIDAKNLFLTYPQC.D.I.Y.KVI.ALKQV.....-KGAL.....F....N........R..GV..K...YIL.....VCKEDHH......E.ND-----------..-----.-.--..---.--------.............-------.......--.-----.-...-------.---.-.--------erklpkyw...............................................
A0A0M9E761_9DELT/4-111              ..........rnpv-----KQLFITFPHS.V.C.D.KCK.FRDDL.....---L-.....-....R........F..EP..D...YYK.....VCEEKHK......D.GTPHLHAVVRFKN..KYSKAfV.LR..HFK.EIY--PDD.............YKRIDVK.......PV.RSIKK.S...IQYLSKE.DPFpL.ESGTFS--ds.....................................................
REP_TYLCI/5-117                     ..............FKIYAKNYFLTYPNC.S.L.S.KEE.ALSQL.....-KKLE.....T....P........T..NK..K...YIK.....VCKELHE......N.GEPHLHVLIQFEG..KYQCK.N.QR..FFD.LVSPNRSA.............HFHPNIQ.......AA.KSSTD.V...KTYVEKD.GNF.I.DFGV----sqid...................................................
A0A0D1YMS2_9EURO/45-153             ..............FRTTGQRFLLTYSQL.R.L.E.TFK.ISELG.....QHLMS.....L....F........N..NP..V..tCVL.....AAKEKHK......D.GGDHVHIYLDVGI..EVQIQ.G.SR..FFD.YCQ-----.............-RHPHIK.......AItKTPHR.A...AAYVMKD.EKV.-.--------ffrhgevp...............................................
L7FKJ3_ENTIV/30-142                 ..............FRLNAKNLLLTWPQT.P.L.P.KEN.AMKQL.....-RTLL.....D....D........Y..GI..I...YIV.....VCQEKHE......K.EGLHLHAVVMLER..KVCFR.D.QS..CLN.LSSDWISK.............DIHGNYL.......SA.KSPKD.A...VAYVKKE.T--.-.--------teelisgeklt............................................
A0A100I8I6_ASPNG/37-127             ............aa--IHCRTVFLTYAQC.S.LeN.KDE.FAAMF.....NEMLE.....R....N........K..LS..K...ATY....yGCREPHR......V.NGIHYHVLLNFGE..QVNW-.-.--..---.--------.............-------.......--.-----.-...-------.---.-.--------sfstarkcltvpgnmcdslnivtr...............................
A0A0F7ZVZ6_9HYPO/16-143             ............fv--LCADVVFVTYTRS.R.VyD.KEE.FHRSL.....TQSLTdslarV....K.......aT..SKvaV...EIF.....GSRELHS......D.GTPHYHVVLRFSA..RIY--.-.--..---.--------.............-------.......--.-----.-...-------.---.-.--------wprarqslsvwivvdgekvvdtnsinirkkrrsesvaeflysvqtyvakggdvfg
REP_MSVS/10-117                     ..............FSHRNANTFLTYPKC.P.E.N.PEI.ACQMI.....-WELV.....V....R........W..IP..K...YIL.....CAREAHK......D.GSLHLHALLQTEK..PVRIS.D.SR..FFD.ING-----.............-FHPNIQ.......SA.KSVNR.V...RDYILKE.PLA.VfERGTFI--pr.....................................................
D8WZ30_TCTVB/8-120                  ..............YRIHAKNIFLTYPHC.H.L.T.KED.ALLQL.....-QTIQ.....C....P........S..TK..K...FIR.....ICRERHD......N.GEPHLHVLIQFEG..KIQLY.N.PR..HFD.LRDGGSGR.............ICHPNIQ.......GA.KSSSD.V...KSYIEKD.GDY.I.DWGEFQID.......................................................
A0A0F8A0B9_9HYPO/36-165             ..............FVLQSRLVFVTYSRS.R.V.SdKEE.FHKYL.....KDSLE.....P....NlpyvgaeeR..AT..V...EIF.....GSKELHE......D.DAPHYHVVLRFSK..KVHWR.Q.ARqkLAV.WIEVDGERvid.......thsI---YIRrkkpgepHE.KWLQD.V...QGYVAKD.GDV.-.--------fgsw...................................................
L7FMK9_ENTIV/38-151                 ..............FRLNAKNLFCTWPQT.A.L.P.KEN.AFKQL.....KTILG.....V....Y........-..GI..K...YLL.....VCQERHE......E.EGLHLHAVAILDK..KVNFK.D.CR..CLD.LSTDWISR.............DIHGQYQ.......AA.RAIRD.A...IAYCKKK.DNW.L.EEGE----spaiq..................................................
#=GC seq_cons                       ..............aphpu+phFLTYsps.s.l.p.+-c.hhp.l......ppLp.....h....p...........t...h...hlh.....sspEtHp......-.Gs.HhHlllphpp..+lphp.s.t+..hFs.l.t...................h+Pphp.......sh.+s.pc.s...hsYltK-.s.h...........st.....................................................
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