GenomeNet

Database: Pfam
Entry: HTH_15
LinkDB: HTH_15
Original site: HTH_15 
#=GF ID   HTH_15
#=GF AC   PF12324.7
#=GF DE   Helix-turn-helix domain of alkylmercury lyase
#=GF AU   Bateman A, Gavin OL
#=GF SE   Pfam-B_3505 (release 6.5)
#=GF GA   26.00 26.00;
#=GF TC   26.10 27.50;
#=GF NC   25.90 25.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Helix-turn-helix
#=GF DR   INTERPRO; IPR024259;
#=GF CC   Alkylmercury lyase (EC:4.99.1.2) cleaves the carbon-mercury bond
#=GF CC   of organomercurials such as phenylmercuric acetate. This is the
#=GF CC   N terminal helix-turn-helix domain associated with Pfam:PF03243.
#=GF SQ   60
#=GS A0A0H5CCT3_9PSEU/2-64     AC A0A0H5CCT3.1
#=GS A0A0Q7U5N2_9MICO/2-72     AC A0A0Q7U5N2.1
#=GS A0A0B2BK92_9ACTN/6-78     AC A0A0B2BK92.1
#=GS E2SED0_9ACTN/3-75         AC E2SED0.1
#=GS A0A077HKA5_9CORY/4-75     AC A0A077HKA5.1
#=GS A0A100W685_9MYCO/104-170  AC A0A100W685.1
#=GS F4CKR9_PSEUX/7-80         AC F4CKR9.1
#=GS G8MQ32_9BURK/2-74         AC G8MQ32.1
#=GS U1LQT7_9MICO/6-76         AC U1LQT7.1
#=GS A0A0S3F5S7_9SPHN/3-74     AC A0A0S3F5S7.1
#=GS A0A0W1SI08_9GAMM/7-75     AC A0A0W1SI08.1
#=GS A0A176I8U8_9GAMM/7-75     AC A0A176I8U8.1
#=GS A0A0D5V3J2_9BURK/5-78     AC A0A0D5V3J2.1
#=GS A0A0M2K6C8_9MYCO/7-78     AC A0A0M2K6C8.1
#=GS V8CUJ7_9ACTN/5-76         AC V8CUJ7.1
#=GS I7IXG7_9CORY/4-75         AC I7IXG7.1
#=GS A0A0M8NNU5_9EURO/12-80    AC A0A0M8NNU5.1
#=GS A0A0J1D4T7_9BURK/5-78     AC A0A0J1D4T7.1
#=GS K9AZL2_9MICO/3-76         AC K9AZL2.1
#=GS A0A132PAZ3_9MYCO/6-76     AC A0A132PAZ3.1
#=GS A0A0D1LE86_9MYCO/2-72     AC A0A0D1LE86.1
#=GS A1TX80_MARHV/7-75         AC A1TX80.1
#=GS G2G622_9ACTN/6-78         AC G2G622.1
#=GS A0A0X3VCQ2_9ACTN/7-78     AC A0A0X3VCQ2.1
#=GS U4L7Y8_PYROM/62-133       AC U4L7Y8.1
#=GS G8MQ18_9BURK/8-79         AC G8MQ18.1
#=GS F3NQD4_9ACTN/7-80         AC F3NQD4.1
#=GS A0A062VKN5_9MICO/3-76     AC A0A062VKN5.1
#=GS A4A3F8_9GAMM/7-75         AC A4A3F8.1
#=GS A0A172UGQ6_9MYCO/6-76     AC A0A172UGQ6.1
#=GS A0A0Q2UJA4_MYCGO/3-76     AC A0A0Q2UJA4.1
#=GS C8PXI0_9PROT/5-78         AC C8PXI0.1
#=GS A0A069DL31_9BACL/7-78     AC A0A069DL31.1
#=GS A0A0D5V4V3_9BURK/5-78     AC A0A0D5V4V3.1
#=GS U2A0X4_9PSED/2-75         AC U2A0X4.1
#=GS A0A0F7N5V0_9ACTN/7-78     AC A0A0F7N5V0.1
#=GS D3PUY2_STANL/7-80         AC D3PUY2.1
#=GS A0A097IGF9_9CORY/4-75     AC A0A097IGF9.1
#=GS G2GNS4_9ACTN/6-78         AC G2GNS4.1
#=GS A0A0Q9M3Q0_9MICC/4-76     AC A0A0Q9M3Q0.1
#=GS D4YL19_9MICO/3-76         AC D4YL19.1
#=GS Q0AM71_MARMM/6-80         AC Q0AM71.1
#=GS B8HJ65_PSECP/5-75         AC B8HJ65.1
#=GS B5EAP1_GEOBB/5-72         AC B5EAP1.1
#=GS C7NGB6_KYTSD/14-83        AC C7NGB6.1
#=GS A0A072TFB1_MEDTR/753-825  AC A0A072TFB1.1
#=GS A0A0P9FHP9_9CHLR/7-76     AC A0A0P9FHP9.1
#=GS B2I418_MYCMM/7-79         AC B2I418.1
#=GS B1MAE1_MYCA9/7-79         AC B1MAE1.1
#=GS A0A0F0LWT7_9MICO/6-75     AC A0A0F0LWT7.1
#=GS A0A139DMW9_9ALTE/7-75     AC A0A139DMW9.1
#=GS A0A0M8VCX8_9ACTN/7-80     AC A0A0M8VCX8.1
#=GS A4V7U8_PSEFS/6-77         AC A4V7U8.1
#=GS U2TEH2_LEIAQ/4-73         AC U2TEH2.1
#=GS L7LNN2_9ACTN/6-76         AC L7LNN2.1
#=GS H5TWU8_9ACTN/4-74         AC H5TWU8.1
#=GS D0L7Y2_GORB4/5-74         AC D0L7Y2.1
#=GS A0A176I7H1_9GAMM/6-75     AC A0A176I7H1.1
#=GS A0A0P9HIX8_9CHLR/4-68     AC A0A0P9HIX8.1
#=GS W9GD57_9MICO/1-70         AC W9GD57.1
A0A0H5CCT3_9PSEU/2-64                ............pals----------------AAEVRIAVALWRLLAEGEPVPVGALADRLGDAAGDVTAAVDGVlaG..SCQRDERGDIVA--f
A0A0Q7U5N2_9MICO/2-72                ..............td-LTTDLSDRLARF----DEEALLVPLLRLLVDGDPVTIDDLAGAVKLPVDEVRARLAAT..P..DTEYDGQGRIIGQG.
A0A0B2BK92_9ACTN/6-78                .............hta----ELVERLAMANQLEGFADLFVVLLRELSKGAPVSPAALALALDWPIERVSVALEQA..V..STEWDDYGNVVGYG.
E2SED0_9ACTN/3-75                    ................DLSSQLPQRLTRPEETGLDAGLLIPLLRLLVDGDAVTVEELAAAAGRTLEEVRRGLAAV..P..DTEYD-QGRIIGQG.
A0A077HKA5_9CORY/4-75                ..........tdqalt--------YLLSPARSGIDPELFVPLLRLLAEGEPVTVAELATASGRSEDTVRQGLAAV..P..DTEYDDEGRIIGL-a
A0A100W685_9MYCO/104-170             .......adsvsrdtd---------------QKTGRHLMRTAVRLLAGGGPVTVADLCAAAGVDRADLTTA-PAG..R..DIEYDDHHRIIGWG.
F4CKR9_PSEUX/7-80                    ................QLVAQLADALYGTGHPATQPWLFRPLLRLLAEGEPVTLDRLAEAAGTSVDQVRQALAAE..P..DTEYDADGRVVGLG.
G8MQ32_9BURK/2-74                    ..........klapyi------LERLTPTNRPKGFAEFLVALLGELAKGRPISRTTLARTLGWPAEQVAAVLEQA..T..STEYDNDGNIIG--y
U1LQT7_9MICO/6-76                    .............arq-----VTERL-ATAESGMQPWLWMPMLRLLAQGNPVILEDLATAVGRPVQEVRGAVEAV..P..DIEYDGEGRIIGLG.
A0A0S3F5S7_9SPHN/3-74                ...............p---TTYIEHFPSISRSQDSAELLVALLRELAKGRPVSRTTLAGILNWPDERIAAVLAQT..A..STEYDDDGNIIGHG.
A0A0W1SI08_9GAMM/7-75                ........iverlglt---------------GEREAALHVTLLRELALGQPVTVERLAKSLNWTTDEAELVLEKL..PcgTIEYDGQGRLIGSG.
A0A176I8U8_9GAMM/7-75                ........iverlglt---------------GEREAALHVTLLRELALGQPVTVERLAKSLNWTTDEAELVLEKL..PcgTIEYDGQGRLIGSG.
A0A0D5V3J2_9BURK/5-78                .............ryt---AELVDRLTMAFRSEGLEELFVVLLRELARGRPVSRGTLALALDWPVERVAAVLQQA..V..STEWDDDGNVVGYG.
A0A0M2K6C8_9MYCO/7-78                ....tvvstmdsvfsr------------QDSP--AGWLWQPLLRQLARGEPLTIADLAAATGRAGDEVAQAVGRL..R..DTEYDDAGRIVGYG.
V8CUJ7_9ACTN/5-76                    ..............pf--ATTIVDTLFDSTANAGTNLMGIA-MRLLAAGEPITIEQLAAAVGADVADVENAPA-A..A..DIEYDDQHRILGWG.
I7IXG7_9CORY/4-75                    ..........tdqalt--------YLLSPARSGIDPELFVPLLRLLAEGEPVTVAELATASGRSEDTVRQGLAAV..P..DTEYDDEGRIIGL-a
A0A0M8NNU5_9EURO/12-80               .eqlknqlladmmaip--------------------AFFPALLRLVSRGEPVPIAALATEVHIPIHDIEQWLRQQ..P..GTDWDSQGRLLGFG.
A0A0J1D4T7_9BURK/5-78                .............hyt---SELVERLTLANRSESFADLFVVLLRELTKGAPVSPAALALALNWPVERVTAALEQA..V..STEWDDDGNVLGYG.
K9AZL2_9MICO/3-76                    ................DLSTQLPDRLNRPEETGLDPGLLVPLLRLLVDGDPVTIEQLATAAGRTPEQACNGLAAV..P..DTEYDDQGRIVGQG.
A0A132PAZ3_9MYCO/6-76                ..........fattiv-------DTLFDS-TANTGTNLMGTAMRLLAAGEPITIEQLATAAGASVADVENAPA-A..A..DIEYDDRHRILGWG.
A0A0D1LE86_9MYCO/2-72                ..............pn-----FLDRLTIPEESGLDPTMLVPLLRLLAAGEPVTVEALAAAVGLPVDEVTRRLAAV..P..DTEYDEQGRIVGQG.
A1TX80_MARHV/7-75                    ........iverlglt---------------GEREAALHVTLLRELALGQPVTVERLAKSLNWTTDEAELVLEKL..PcgTIEYDGQGRLIGSG.
G2G622_9ACTN/6-78                    ..............rk-LATRFTDTV--NRAPGVKLSLLRPLLTLLASGEPVTLDQLAAQADRTVDEIRQALADM..P..DTEYDTAGRIIGNG.
A0A0X3VCQ2_9ACTN/7-78                ................QFATRFLDAV--SSAPGLNFPLLRLVQTLLVSGGPVTLDQLAAWANRPVAEIHEALAAM..P..DTEYDAEGRIIGYG.
U4L7Y8_PYROM/62-133                  ................ELVTLFDQN--KGEGGGSMKWLFRPLLQMLTKGEPVTVEDIATTTGKPLDEVKDILSTL..S..SVELDEQGRVVGFG.
G8MQ18_9BURK/8-79                    ...............p---TTYIEHFPSISRSQDSAELLVALLRELAKGRPVSRTTLAGILNWPDERIAAVLAQT..A..STEYDDDGNIIGHG.
F3NQD4_9ACTN/7-80                    ...............k-LADRLTAALGGGENVTGQPWLWRPLLQLLATGRPVTTGQLATATSHTEDDVRHALAAM..P..DTEYDGTGRIIGSG.
A0A062VKN5_9MICO/3-76                ................DLSTQLPNRFDRPEETGLDPGLLVPLLRLLADGDPVTIEQLAVAAGRTPDQVRRGLAAA..P..DTEYDEQGRVVGQG.
A4A3F8_9GAMM/7-75                    ........iverlglt---------------GEREAALHVTLLRELALGQPVTVERLAKSLNWTTDEAELVLEKL..PcgTIEYDGQGRLIGYG.
A0A172UGQ6_9MYCO/6-76                ..........fattiv-------DTLFDS-TANTGTNLMGTAMRLLAAGEPITIEQLATAAGASVADVENAPA-A..A..DIEYDDRHRILGWG.
A0A0Q2UJA4_MYCGO/3-76                ...............p-LANRLTDLLGSTDNPSSTRWLFRPLLELLAHGQPVTTEQLADATASTVDQMRAALATM..P..DTEYDDRGRIIGNG.
C8PXI0_9PROT/5-78                    ..............ry--VTEIANRLIPANQPKNLASLFSVLLHELIKGQSVSPTILATALNCDLEQLASILKEI..P..GIEYDNTGDIVGYG.
A0A069DL31_9BACL/7-78                ................ELVTLFDQN--KGEGGGSMKWLFRPLLQMLTKGEPVTVEDIATTTGKPLDEVKDILSTL..S..SVELDEQGRVVGFG.
A0A0D5V4V3_9BURK/5-78                .............rya---AELVERLTMANQLEGFADLFVVLLRELSKGAPVSPAALALALDWPVGRVTAALAQA..V..STEWDDDGNVVGYG.
U2A0X4_9PSED/2-75                    ..........klapyi------LERLTSVNRTNGTADLLVPLLRELAKGRPVSRTTLAGILDWPAERVAAVLEQA..T..STEYDKDGNIIGYG.
A0A0F7N5V0_9ACTN/7-78                ...............a-FAARFTTSL--GNAPGLTMPLLRPLLTLLATREPVTISQLAEHAGRSEEDIRHTLACM..P..DTEYDTQGRIIGFG.
D3PUY2_STANL/7-80                    ...............r-FDTWLSTSLADSEVGGGAWTIARSIQKLLLDGKPVPVAGLAAETGRSVEEVEQALEAM..P..SVEREPDGTVVGFG.
A0A097IGF9_9CORY/4-75                ..........tdqalt--------YLLSPARSGIDPELFVPLLRLLAEGEPVTVAELATASGRSEDTVRQGLAAV..P..DTEYDDEGRIIGL-a
G2GNS4_9ACTN/6-78                    ..............qn-LAARFTDTV--NRAPGVKLWLLRPLLTLLATGEPVTVDQLAAQAGRTVDEIREALADM..A..DTEYDTQGRIIGNG.
A0A0Q9M3Q0_9MICC/4-76                ...........tdhqa------LTYLLSPSRSGIKPELFVPLLRLLAEGEPVTVADLATASGRSEDTVRQGLAAV..P..DTEYDEEGRILGLG.
D4YL19_9MICO/3-76                    ................ELTTQLPERLNNTEETGLDAVLLIPLLRLIVEGGPVTVEQFAAAAGRPVDAVRTGLAAV..P..DTEYDDQGRIIGQG.
Q0AM71_MARMM/6-80                    ..qitavleagyigen---------------PKDLQRASLYIYRALASGKPISIASIAEHLGTPLETASRLLNLV..PpsAIELDDDGHIIGF-v
B8HJ65_PSECP/5-75                    ............ishv------TERL-ATGETGMQPWLWLPLMKLLALGDPVDIADLAAATGRPVEEIRAALEAM..A..DTEYDGSGRIVGQG.
B5EAP1_GEOBB/5-72                    tlhdvlaglhcdhprv--------------------WL--FLLRALAKGRPVSRTTIANALNSSLSEIEAALASF..A..DTVYDEKGDVVACG.
C7NGB6_KYTSD/14-83                   ...............d-LSMQLPERLSRLGE----TGLLIPLLRLLADGDPVTVQQLSVAAGRTIDEVRLGLAAM..Q..DTEYDDQGRIVGQG.
A0A072TFB1_MEDTR/753-825             .............hta----ELVERLAMANQLEGFADLFVVLLRELSKGAPVSPAALALALDWPIERVSVALEQA..V..STEWDDYGNVVGYG.
A0A0P9FHP9_9CHLR/7-76                .....tslaatvadrl---------------CGENEHICVALIRQLAAGQPVSTAHLAADIAMEEPAVNAVLQQM..S..DVAYDGDGQVIGFG.
B2I418_MYCMM/7-79                    ................QLAHRLNDSL-GGDNPGSTPWMLRPLLDLLAHGAPVTIDQLADATATTVEQVRHALTAM..S..DTEYDEHGRIIGSG.
B1MAE1_MYCA9/7-79                    ................QLAHRLNDSL-GGDNPGSTPWMLRPLLDLLAHGAPVTIDQLADATATTVEQVRHALTAM..S..DTEYDEHGRIIGSG.
A0A0F0LWT7_9MICO/6-75                ............aait-------DRL-ATAETGLEIWLWLPLLKLLAEGEPVTIADLATATGRTADEVQAALAAV..P..DTEYDDEGQIIGQG.
A0A139DMW9_9ALTE/7-75                ........iverlglt---------------GEREAALHVTLLRELALGQPVTVERLAKSLNWTTDEAELVLEKL..PcgTIEYDGQGRLIGSG.
A0A0M8VCX8_9ACTN/7-80                ...............k-LADRLTAALGGGENVTGQPWLWRPLLQLLATGRPVTTGQLATATSHTEDDVRHALAAM..P..DTEYDETGRIIGSG.
A4V7U8_PSEFS/6-77                    ..............yi---TEIAERLTPTNRPKGFAEFLVALLGELAKGRPISRTTLARTLGWPAEQVAAVLEQA..T..STEYDNDGNIIG--y
U2TEH2_LEIAQ/4-73                    ..............nd----TLAERL-TSSETGQEASLWLPLMKLLAQGDPVEVSTLATVTGRSEADVQQALAAV..P..DIEYE-YGRIIGQG.
L7LNN2_9ACTN/6-76                    ..........ektlay---------LLSPSRSGLDPSLFVPLLRLLAEGEPVTIAELATASGRSENTVRRGLSSV..P..DAEYDDDGRILGL-a
H5TWU8_9ACTN/4-74                    ...........dnlta-------DVFAKILPAGRDRALMRAALRLLAHGTPVTVTELAAAAGVPDLDPAQT-PIG..A..DVEYDEAGRIVGWG.
D0L7Y2_GORB4/5-74                    .........sipadvf----------ATIAPADRDRALLRAALRLLAHGAPVTVTELAAAAGVDAGDLEET-PIG..A..DIEYDEQGRVLGWG.
A0A176I7H1_9GAMM/6-75                .......eiverlglt---------------GEREAALHVTLLRELALGQPVTVERLAKSLNWTTDEAELVLEKL..PcgTIEYDGQGRLIGSG.
A0A0P9HIX8_9CHLR/4-68                .........ilaeric----------------GTNEAFCFQLLRLLGQGQPVSAAQMGAALGISDIAVTETFQRM..P..DIERDEIGQVVGWG.
W9GD57_9MICO/1-70                    ...............e-----LTARLARTDETGLDAGLLIPLLRLLVDGEPVSVEQLAAAAGRRAEEVRRALAAV..P..DTEYDDQDRIVGQG.
#=GC seq_cons                        ...............h.......ptL..stpsstpstLhlsLLRLLAcGcPVTlspLAsAsutss-cVctuLsth..s..DTEYD-pGRIlG.G.
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