GenomeNet

Database: Pfam
Entry: Hepatitis_core
LinkDB: Hepatitis_core
Original site: Hepatitis_core 
#=GF ID   Hepatitis_core
#=GF AC   PF00906.17
#=GF DE   Hepatitis core antigen
#=GF AU   Bateman A
#=GF SE   Pfam-B_8 (release 3.0)
#=GF GA   22.60 17.00;
#=GF TC   196.30 35.20;
#=GF NC   20.60 16.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   399329
#=GF RT   Hepatitis B virus genes and their expression in E. coli. 
#=GF RA   Pasek M, Goto T, Gilbert W, Zink B, Schaller H, Mckay P,
#=GF RA   Leadbetter G, Murray K; 
#=GF RL   Nature 1979;282:575-579.
#=GF RN   [2]
#=GF RM   2677399
#=GF RT   A recombinant hepatitis B core antigen polypeptide with the
#=GF RT   protamine-like domain deleted self-assembles into capsid
#=GF RT   particles but fails to bind nucleic acids. 
#=GF RA   Gallina A, Bonelli F, Zentilin L, Rindi G, Muttini M, Milanesi
#=GF RA   G; 
#=GF RL   J Virol 1989;63:4645-4652.
#=GF DR   INTERPRO; IPR002006;
#=GF DR   SCOP; 1qgt; fa;
#=GF CC   The core antigen of hepatitis viruses possesses a carboxyl
#=GF CC   terminus rich in arginine. On this basis it was predicted that
#=GF CC   the core antigen would bind DNA [1]. There is some experimental
#=GF CC   evidence to support this [2].
#=GF SQ   8
#=GS CAPSD_DHBVQ/2-260    AC Q66406.1
#=GS CAPSD_HBVCJ/2-87     AC Q76R61.1
#=GS HBEAG_HBVCJ/107-174  AC P0C767.1
#=GS CAPSD_HBVCJ/143-183  AC Q76R61.1
#=GS CAPSD_HBVCJ/79-145   AC Q76R61.1
#=GS HBEAG_HBVCJ/172-212  AC P0C767.1
#=GS HBEAG_DHBVQ/45-303   AC Q89860.1
#=GS HBEAG_HBVCJ/31-115   AC P0C767.1
CAPSD_DHBVQ/2-260               .........DINASRALANVYD....LPDDFFPKIDDLVRDA....KDALE......PYWKSDSIKKHVLIATHFVDLIEDFWQTTQGMHEIAESLRAVIPPTTAPVPTGYLIQHEEAEEIPLGDLFKHQEERIVSFQPDYPITARIHAHLKAYAKINEESLDRARRLLWWHYNCLLWGEANVTNYISRLRTWLSTPEKYRGRDAPTIEAITRPIQAAQGGRKTSSGTRKPRGLEPRRRKVKTTVVYGRRRSKSRERRAPSPQRAGSPLPRSSSSHHRSPSP...............
CAPSD_HBVCJ/2-87                .........DIDPYKEFGASVEllsfLPSDFFPSIRDLLDTAsalyREALEspehcsPH--HTALRQAILCWGELMNLAT--WV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------gsnledpasrelvvs
HBEAG_HBVCJ/107-174             dpasrelvv-------------....----------------....-----......-------------------------------------------------------------------------------------------------SYVNVNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILS--TLP--------------------------------------------------------------------e..............
CAPSD_HBVCJ/143-183             .......lp-------------....----------------....-----......----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETTVV--RRRGRSPRRRTPSPRRRRSQSPRRRRSQSRESQC...............
CAPSD_HBVCJ/79-145              .pasrelvv-------------....----------------....-----......-------------------------------------------------------------------------------------------------SYVNVNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILS--TLP--------------------------------------------------------------------e..............
HBEAG_HBVCJ/172-212             .......lp-------------....----------------....-----......----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETTVV--RRRGRSPRRRTPSPRRRRSQSPRRRRSQSRESQC...............
HBEAG_DHBVQ/45-303              .........DINASRALANVYD....LPDDFFPKIDDLVRDA....KDALE......PYWKSDSIKKHVLIATHFVDLIEDFWQTTQGMHEIAESLRAVIPPTTAPVPTGYLIQHEEAEEIPLGDLFKHQEERIVSFQPDYPITARIHAHLKAYAKINEESLDRARRLLWWHYNCLLWGEANVTNYISRLRTWLSTPEKYRGRDAPTIEAITRPIQAAQGGRKTSSGTRKPRGLEPRRRKVKTTVVYGRRRSKSRERRAPSPQRAGSPLPRSSSSHHRSPSP...............
HBEAG_HBVCJ/31-115              .........DIDPYKEFGASVEllsfLPSDFFPSIRDLLDTAsalyREALEspehcsPH--HTALRQAILCWGELMNLAT--WV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------gsnledpasrelvv.
#=GC seq_cons                   .........................................................................................................................................................................................................................................................................................................
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