GenomeNet

Database: Pfam
Entry: Herpes_DNAp_acc
LinkDB: Herpes_DNAp_acc
Original site: Herpes_DNAp_acc 
#=GF ID   Herpes_DNAp_acc
#=GF AC   PF04929.9
#=GF DE   Herpes DNA replication accessory factor 
#=GF AU   Finn RD
#=GF SE   Pfam-B_5837 (release 7.6)
#=GF GA   25.00 25.00;
#=GF TC   457.00 449.50;
#=GF NC   22.40 21.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10882068
#=GF RT   The crystal structure of an unusual processivity factor, herpes
#=GF RT   simplex virus UL42, bound to the C terminus of its cognate
#=GF RT   polymerase. 
#=GF RA   Zuccola HJ, Filman DJ, Coen DM, Hogle JM; 
#=GF RL   Mol Cell 2000;5:267-278.
#=GF RN   [2]
#=GF RM   9934686
#=GF RT   Identification of transactivator and nuclear localization
#=GF RT   domains in the Epstein-Barr virus DNA polymerase accessory
#=GF RT   protein, BMRF1. 
#=GF RA   Zhang Q, Holley-Guthrie E, Dorsky D, Kenney S; 
#=GF RL   J Gen Virol 1999;80:69-74.
#=GF DR   INTERPRO; IPR007013;
#=GF CC   Replicative DNA polymerases are capable of polymerising tens of
#=GF CC   thousands of nucleotides without dissociating from their DNA
#=GF CC   templates. The high processivity of these polymerases is
#=GF CC   dependent upon accessory proteins that bind to the catalytic
#=GF CC   subunit of the polymerase or to the substrate.  The Epstein-Barr
#=GF CC   virus (EBV) BMRF1 protein is an essential component of the viral
#=GF CC   DNA polymerase and is absolutely required for lytic virus
#=GF CC   replication [2]. BMRF1 is also a transactivator [2].  This
#=GF CC   family is predicted to have a UL42 like structure [1].
#=GF SQ   6
#=GS VG59_EHV2/8-414    AC Q66661.1
#=GS PAP_HHV8P/6-396    AC F5HID2.1
#=GS VG59_ALHV1/4-408   AC O36409.1
#=GS VG59_SHV21/10-368  AC Q01052.1
#=GS EAD_EBVA8/4-404    AC P0C6Z0.1
#=GS EAD_EBVB9/4-404    AC P03191.1
#=GS EAD_EBVB9/4-404    DR PDB; 2Z0L B; 4-299;
#=GS EAD_EBVB9/4-404    DR PDB; 2Z0L E; 4-299;
#=GS EAD_EBVB9/4-404    DR PDB; 2Z0L A; 4-299;
#=GS EAD_EBVB9/4-404    DR PDB; 2Z0L D; 4-299;
#=GS EAD_EBVB9/4-404    DR PDB; 2Z0L G; 4-299;
#=GS EAD_EBVB9/4-404    DR PDB; 2Z0L F; 4-299;
#=GS EAD_EBVB9/4-404    DR PDB; 2Z0L H; 4-299;
#=GS EAD_EBVB9/4-404    DR PDB; 2Z0L C; 4-299;
VG59_EHV2/8-414               .THCMALNVENFKACAKIHNHVKNYLKKGLVQIVGFETE...PVFQIMATACDGGILVFKVL.NPFESFNVSYSRME-TLSLSFKN.QPHGNTYLYSKDLFGEAVKGASLTFLQRPGLC..--RP.DFVRSDVLMDDDVTTSSHCTSLT.SWSPPAHD-IRAGTVMSKVVLSIKTCTMLQKWLKDQKSKGePrCVRLCLNEILSVLVLSVGEASKTVHLK.....PVEGNPATSLLF.ADKQG.DVCIISDDEAHDVSLDSLLAALGVCRIPALCLPCFNFHSNGVLEVVGLQFKSSKPASGELSVFLLRANPQVDFNGVPEGDVQT....QEVSSVASTCRHLSESCSLD..-PPRTP..ELPGSPDTFKEIPGRSGsvhlerdlscsdseEETPKQKP..AKAKPAAAPKRSE----.......KRKREGGKKGPKAKSL...KLTFNPLI
PAP_HHV8P/6-396               .HYGVRVDVTLLSKIRRVNEHIKSATKTGVVQVHGSACT...PTLSVLSSVGTAGVLGLRIK.NALTPL-VGHTEGSGDVSFSFRN.TSVGSGFTHTRELFGANVLDAGIAFYRKGEACdtGAQP.QFVRTTISYGDNLTSTVHKSVVDqKGILPFHDRMEAGGRTTRLLLCGKTGAFLLKWLRQQKTKE.DqTVTVSVSETLSIVTFSLGGVSKIIDFK.....P-ETKPVSGWDGlKGKKSvDVGVVHTDALSRVSLESLIAALRLCKVPGWFTPGLIWHSNEILEVEGVP-TGCQSGDVKLSVLLL----EVNRSVSAEGGESS....QKVPDSIPDSRRQPELESPD..SPPLTP..VGPFGPLEDASEDAASV..............--------..TSCPPAAPTKDSTKRPH.......KRRSDSSQSRDRGKVP...KTTFNPLI
VG59_ALHV1/4-408              .CASFRLSPALLTSSTKIYDHVKSHLKSAMIQFSDLNTT...PVMSIISNMGSAGIVTFQLT.GAVSDTE---TLAEITEPLAFRN.HSFGGTYLHSREFFGKEIEDILVRFYKRASTA..SKLP.EFVETKITYNNSITETRHTSTVD.SHVSPVEKYLQKCFVKAKLILSIKTCTMLQKWLRQNKNKS.P.VARLHINETLTVLVVTVGDECTTIEFK.....SFVLEPADAFLT.LDKPG.NFGAVLVDCTAVVNLECLIQAIGICKVPSVCVPAFKFYSGGIVEVSSAHLKQSKSPSATVSTVLLDASESLKQPAEQEQPTTS....QPSDPQSSNSVDKPSPPRPSisQPVRRR..APPRAIISDSEEDSDSDsdqdc...stetqpETSYREEPkkFTPKPTAPPN-------.......KRKQFEPLKCPVEKKK...KSNSNSFV
VG59_SHV21/10-368             s-YGVGFKPCVLQEHTKIYNHIKAKVKDGIIQIEGLTSS...PSLRIWSSIGE-GILSFKIN.NVVSEVFNCHMMPE-NVSVSFRNiSPGGNTFLYTRELFGCNVKTATLMFSNR----..SGKPfEFIKAKLEYCDKVSTTRHTSTIP.AGILPFVENVNSTSVLSRVVLSPKTAAMLQKWLREHKAHK.-.TVSVMVNSTLAVLILTVEDSTKTVDLHivddmSLCNNPSK----.-----.DWGVVQNDVQTKVNITALSAALGLCKIPGVFVPCIKFYESEVLEVCGTPVKLGSWVDTSLQVTLF---------CTPNLAEDT....QAAVSD--------------..------..YFPISP-----------..............SACLTADPadTQEEPTLSSNCQDSSVEnspalplKRKREK-DINKKSKKI...KIAFNPLI
EAD_EBVA8/4-404               .TQTLRFKTKALAVLSKCYDHAQTHLKGGVLQVNLLSVNyggPRLAAVANAGTAGLISFEVSpDAVAEWQNHQSPEEAPAAVSFRN.LAYGRTCVLGKELFGSAVEQASLQFYKRPQG-..GSRP.EFVKLTMEYDDKVSKSHHTCALM.PYMPPASDRLRNEQMIGQVLLMPKTASSLQKWARQQGSGG.-.-VKVTLNPDLYVTTYTSGEACLTLDYK.....PLSVGPYEAFTGpVAKAQ.DVGAVEAHVVCSVAADSLAAALSLCRIPAVSVPILRFYRSGIIAVVAGLLTSAGDLPLDLSVILFNHASEEAAASTASEPEDKsprvQPLGTGLQQRPRHTVSPSPSppPPPRTPtwESPARP-----------..............--------..ETPSPAIPSHSSNTALErplavqlARKRTSSEARQKQKHPkkvKQAFNPLI
EAD_EBVB9/4-404               .TQTLRFKTKALAVLSKCYDHAQTHLKGGVLQVNLLSVNyggPRLAAVANAGTAGLISFEVSpDAVAEWQNHQSPEEAPAAVSFRN.LAYGRTCVLGKELFGSAVEQASLQFYKRPQG-..GSRP.EFVKLTMEYDDKVSKSHHTCALM.PYMPPASDRLRNEQMIGQVLLMPKTASSLQKWARQQGSGG.-.-VKVTLNPDLYVTTYTSGEACLTLDYK.....PLSVGPYEAFTGpVAKAQ.DVGAVEAHVVCSVAADSLAAALSLCRIPAVSVPILRFYRSGIIAVVAGLLTSAGDLPLDLSVILFNHASEEAAASTASEPEDKsprvQPLGTGLQQRPRHTVSPSPSppPPPRTPtwESPARP-----------..............--------..ETPSPAIPSHSSNTALErplavqlARKRTSSEARQKQKHPkkvKQAFNPLI
#=GR EAD_EBVB9/4-404    SS    .EEEEE-TTTCGGGHHHHHHHHHHHTTSEEEEESGGGTTTS-EEEEEEEESTTEEEEEEE-GGGEEEEEE-S-TTTS-SEEEEESB.SSSSSBHHHHHT-TTEEEEEEEEEE-SSS-S-..EEEE.EEETTSS-EEEEEEE--S----G.GTCGGS-EEEEEE--HHHHHHHHHHHHHTTTSEEEEEEET.-.-EEEEETTEEEEEE-EE-SS-GGGSS-.....TS-EEEESS-EEEEEEHH.HHHHHHHT-BTTTEEEEEEEETTSEEEEEEEEBTTS----EEEEEEE-----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----------..............--------..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
#=GC SS_cons                  .EEEEE-TTTCGGGHHHHHHHHHHHTTSEEEEESGGGTTTS-EEEEEEEESTTEEEEEEE-GGGEEEEEE-S-TTTS-SEEEEESB.SSSSSBHHHHHT-TTEEEEEEEEEE-SSS-S-..EEEE.EEETTSS-EEEEEEE--S----G.GTCGGS-EEEEEE--HHHHHHHHHHHHHTTTSEEEEEEET.-.-EEEEETTEEEEEE-EE-SS-GGGSS-.....TS-EEEESS-EEEEEEHH.HHHHHHHT-BTTTEEEEEEEETTSEEEEEEEEBTTS----EEEEEEE-----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----------..............--------..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
#=GC seq_cons                 .stslRhcspsLsshoKlY-HlKo+LKsGllQlssLsss...PsLullussGoAGlloFcls.sAVu-hpsppo.tEhssulSFRN.puaGsTalao+ELFGssVcsAoLpFY+Rsps...uu+P.EFV+sslpYsDcVopo+HTosls.sahsPspDplcssphhu+VlLssKTuohLQKWLRQQKo+u...sV+VslNpsLsVlshTlG-uspTlDaK.....PlsssPscuahs.hsKtt.DVGsVpsDssssVul-SLhAALuLC+IPuVsVPsl+FYpuGIlEVsus.lpuupsssscLSVlLhpts.p.stsuosptsEso....Qslsoshppp.+ps.ssSPs...PPRTP..tsPtuP...................................pospPAhPo+sSspt.c.......KRKRpuuctppKpK+....KpsFNPLI
//
DBGET integrated database retrieval system