#=GF ID Herpes_DNAp_acc
#=GF AC PF04929.7
#=GF DE Herpes DNA replication accessory factor
#=GF AU Finn RD
#=GF SE Pfam-B_5837 (release 7.6)
#=GF GA 25.00 25.00;
#=GF TC 254.70 254.30;
#=GF NC 21.80 21.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 10882068
#=GF RT The crystal structure of an unusual processivity factor, herpes
#=GF RT simplex virus UL42, bound to the C terminus of its cognate
#=GF RT polymerase.
#=GF RA Zuccola HJ, Filman DJ, Coen DM, Hogle JM;
#=GF RL Mol Cell 2000;5:267-278.
#=GF RN [2]
#=GF RM 9934686
#=GF RT Identification of transactivator and nuclear localization
#=GF RT domains in the Epstein-Barr virus DNA polymerase accessory
#=GF RT protein, BMRF1.
#=GF RA Zhang Q, Holley-Guthrie E, Dorsky D, Kenney S;
#=GF RL J Gen Virol 1999;80:69-74.
#=GF DR INTERPRO; IPR007013;
#=GF CC Replicative DNA polymerases are capable of polymerising tens of
#=GF CC thousands of nucleotides without dissociating from their DNA
#=GF CC templates. The high processivity of these polymerases is
#=GF CC dependent upon accessory proteins that bind to the catalytic
#=GF CC subunit of the polymerase or to the substrate. The Epstein-Barr
#=GF CC virus (EBV) BMRF1 protein is an essential component of the viral
#=GF CC DNA polymerase and is absolutely required for lytic virus
#=GF CC replication [2]. BMRF1 is also a transactivator [2]. This
#=GF CC family is predicted to have a UL42 like structure [1].
#=GF SQ 24
#=GS EAD_EBVG/4-404 AC Q3KSU3.1
#=GS Q77ZG5_HHV8/6-396 AC Q77ZG5.1
#=GS Q77ZG5_HHV8/6-396 DR PDB; 3I2M X; 6-300;
#=GS Q77ZG5_HHV8/6-396 DR PDB; 3HSL X; 6-300;
#=GS Q993F6_9GAMA/4-400 AC Q993F6.1
#=GS P88996_MHV68/1-394 AC P88996.1
#=GS Q9YTK8_ATHV3/10-366 AC Q9YTK8.1
#=GS F5HID2_HHV8P/6-396 AC F5HID2.1
#=GS EAD_EBVA8/4-404 AC P0C6Z0.1
#=GS Q9WRN5_9GAMA/6-394 AC Q9WRN5.1
#=GS VG59_ALHV1/4-408 AC O36409.1
#=GS VG59_SHV21/10-368 AC Q01052.1
#=GS G1EUL5_BHV4/6-391 AC G1EUL5.1
#=GS Q918P2_9GAMA/4-389 AC Q918P2.1
#=GS D0U1P8_MHV68/1-396 AC D0U1P8.1
#=GS EAD_EBVB9/4-404 AC P03191.1
#=GS EAD_EBVB9/4-404 DR PDB; 2Z0L B; 4-299;
#=GS EAD_EBVB9/4-404 DR PDB; 2Z0L E; 4-299;
#=GS EAD_EBVB9/4-404 DR PDB; 2Z0L A; 4-299;
#=GS EAD_EBVB9/4-404 DR PDB; 2Z0L G; 4-299;
#=GS EAD_EBVB9/4-404 DR PDB; 2Z0L D; 4-299;
#=GS EAD_EBVB9/4-404 DR PDB; 2Z0L F; 4-299;
#=GS EAD_EBVB9/4-404 DR PDB; 2Z0L H; 4-299;
#=GS EAD_EBVB9/4-404 DR PDB; 2Z0L C; 4-299;
#=GS P88950_HHV8/6-396 AC P88950.1
#=GS Q77NI0_9GAMA/6-394 AC Q77NI0.1
#=GS E9M5P2_9GAMA/2-421 AC E9M5P2.1
#=GS Q80BM1_SHV2/10-371 AC Q80BM1.1
#=GS Q8UZI4_9GAMA/4-404 AC Q8UZI4.1
#=GS VG59_EHV2/8-414 AC Q66661.1
#=GS Q2VSI2_9GAMA/4-389 AC Q2VSI2.1
#=GS Q99CY3_BHV4/6-391 AC Q99CY3.1
#=GS Q53CV4_9GAMA/6-394 AC Q53CV4.1
#=GS G3CKQ3_EBVG/4-404 AC G3CKQ3.1
EAD_EBVG/4-404 ..TQTLRFKTKALAVLSKCYDHAQTH.LK.GGVLQv...nlLSVNY.GGPRLAAVANAGTAGLISFEVSpDAVAEWQNHQ......sPEEAPAAVSFRN.LAYGRTCVLGKELFGSAVEQASLQFYKR...pQGGSRP..EFVKLTMEYDDKVS.KSHHTCAL.MPYMPPASDRLRNEQMIGQVLLMPKTASSLQKWARQQGS--..GGVKVTLNPDLYVTT.YTSGEACLTLDYKPLS...vGPYEAFTGPVAKAQDSGAVEAHVVCSVAADSLAAALSLCRIPAVSVPILRFYRSGIIAVVAGLLTSAGDLPLDLSVILFNHASEEAAASTASEPEdkspr..............vqplgTGLQQRPRH..TVSPSPSPPPpp...........................rtPTWESPARPETPSPAIPSHSSNTALERP.LAV..QLAR..KRTSSE.....aRQKQKHPKKVKQAFNPLI.
Q77ZG5_HHV8/6-396 ..HYGVRVDVTLLSKIRRVNEHIKSA.TK.TGVVQ......VHGSA.CTPTLSVLSSVGTAGVLGLRIK.NALTPLVGHT.......EGSGDVSFSFRN.TSVGSGFTHTRELFGANVLDAGIAFYRKgeacDTGAQP..QFVRTTISYGDNLT.STVHKSVVdQKGILPFHDRMEAGGRTTRLLLCGKTGAFLLKWLRQQKTKE.dQTVTVSVSETLSIVT.FSLGGVSKIIDFKPET...kPVSGWDGLKGKKSVDVGVVHTDALSRVSLESLIAALRLCKVPGWFTPGLIWHSNEILEVEGVPT-GCQSGDVKLSVLLLEVNRSVSAEGGESSQKv......................pDSIPDSRRQ..PELESPDSPPl............................tpVGPFGPLEDASEDAASVTSCPPAAPTKD.STK..RPHK..RR-SDS......SQSRDRGKVPKTTFNPLI.
#=GR Q77ZG5_HHV8/6-396 SS ..-EEEEE-HHHHHHHHHHHHHHHHH.HT.TSEEE......EEEET.TSEEEEEEEE-TTSEEEEEEES.S-EEE-TT-T.......TTTSEEEEEEES.B-TT-S-BHHHHHT-TTEEEEEEEEE-XXXXXXXXXX-..-EEEEEEEESSTT-.EEEEEEE---TTS---TT-S-SSTT-EEEE--HHHHHHHHHHHHTT--SS.--EEEEEEETTTTEEE.EEETTEEEEEE-EE-S...S--BTTBTTB-TTSS-EEE-SS-EEEEEEHHHHHHHHHHT-BTTTEEEEEEE-SSS-EEEEEEES-SSTTTTEEEEEEE---XXXXXXXXXXXXXXX......................XXXXXXXXXX..XXXXXXXXXXX............................XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXX..XXXX..XX-XXX......XXXXXXXXXXXXXXXXXX.
Q993F6_9GAMA/4-400 ..TQSLVFVPGALATLSKCYEHVQTH.LK.TGIIQvslvgsLNSAQ.AVPRFILSSNMLQTARLQFEVTeRAIAEWHNHQ......nEADSPATLSVRN.MAYGRTFLLARELFSHAVKEASFKFYRK....-TDGGP..QFVRMILEYDDLST.MMHHTAVL.EPYVAPFGDALSGERLVGRVLLSPKTTMGLQKFTRVRGA--..APVRITLNPDLYVLTcIGEDDGCHTVDYKPVS...vPARDSFATPITKAIDSAAADSHVMSRAAANALCTALGLCRIPGVSVPILNFYESGLLCVSAALLTTASHLPLDLRVVLFNPSYKNDGDVHNPEAVkiqe...............ewpirATVSPKPCH..LLTDISQSPP...............................---VCSPPHQTPLPALNSITEPQEFARC.VAS..TFQR..KRNCTEe...tvSKQKKPSKKLKLSFNPLI.
P88996_MHV68/1-394 ..MQTFQLDTERLCQAAKLYQHTKSD.FGlNGMIQ......LSGSC.NNMSLSVLGSIGGCAILRLELL.-EAARLHSSK.......DSSKSAIYSFRNaSSLGREFTHGGELFGPKMESASLSFYGH....HGVKYVeaQFVH------DSSS.KTVHTAAM.QPITIPPSCAFDDREANGIVTLSTKTAAALVKWLKQHTKTC.qSPVKVSISEILGVMV.LSVGDASMTVDVTPVN....VSSGKKTRGGNKASDSGTISADATVHVNGHCLIRSLIVCKVPGCTTPRVKFHACGILEVDGAPVKQGELTQVKLSVALLNVDSSTGRVLKEPVVT........................GASKDRGAS..KSEDADGSPPvpdhp....................kesltsDSDSSVPGPRSTDLSSLTHTPSDRFSSD.LRSgcGGQQflKRPPPK......KDREPTTKRPKLHFNHF-p
Q9YTK8_ATHV3/10-366 ..TYGVGFKPSVLQENTKIYNHIRAK.VK.DGIIQ......IEGPT.ASPSLRVWSSIGD-GVLSFKID.NVVSEVFNCH.......MMPENVSVSFRNiSPGGNTFLYTRELFGFNVKTATLMFSNR....--SGKP.fEFIKAKLEYCDKVS.TTRHTSTI.TAGILPFANNVNSTNGLSRVVLTPKTAAMLQKWLRDHRTH-..RTVSVGVNSTLAALI.LSVGDSTKTVDLQIVD....----DIATCNNTNKDWGFVQSDTWATVNITALSMALGLCKIPGVFVPGIKFCEGEVLEVRGMPVKLGSWTDTSLEVTLFSTHNTSEDTE------........................---TDLLQE..TQNTSVVSSP...............................-----ADSAETQEQAVSSISQDSVVEKP.-IL..SLKR..KKDKEL......---DKKSKKAKIAFNPLI.
F5HID2_HHV8P/6-396 ..HYGVRVDVTLLSKIRRVNEHIKSA.TK.TGVVQ......VHGSA.CTPTLSVLSSVGTAGVLGLRIK.NALTPLVGHT.......EGSGDVSFSFRN.TSVGSGFTHTRELFGANVLDAGIAFYRKgeacDTGAQP..QFVRTTISYGDNLT.STVHKSVVdQKGILPFHDRMEAGGRTTRLLLCGKTGAFLLKWLRQQKTKE.dQTVTVSVSETLSIVT.FSLGGVSKIIDFKPET...kPVSGWDGLKGKKSVDVGVVHTDALSRVSLESLIAALRLCKVPGWFTPGLIWHSNEILEVEGVPT-GCQSGDVKLSVLLLEVNRSVSAEGGESSQKv......................pDSIPDSRRQ..PELESPDSPPl............................tpVGPFGPLEDASEDAASVTSCPPAAPTKD.STK..RPHK..RR-SDS......SQSRDRGKVPKTTFNPLI.
EAD_EBVA8/4-404 ..TQTLRFKTKALAVLSKCYDHAQTH.LK.GGVLQv...nlLSVNY.GGPRLAAVANAGTAGLISFEVSpDAVAEWQNHQ......sPEEAPAAVSFRN.LAYGRTCVLGKELFGSAVEQASLQFYKR...pQGGSRP..EFVKLTMEYDDKVS.KSHHTCAL.MPYMPPASDRLRNEQMIGQVLLMPKTASSLQKWARQQGS--..GGVKVTLNPDLYVTT.YTSGEACLTLDYKPLS...vGPYEAFTGPVAKAQDVGAVEAHVVCSVAADSLAAALSLCRIPAVSVPILRFYRSGIIAVVAGLLTSAGDLPLDLSVILFNHASEEAAASTASEPEdkspr..............vqplgTGLQQRPRH..TVSPSPSPPPpp...........................rtPTWESPARPETPSPAIPSHSSNTALERP.LAV..QLAR..KRTSSE.....aRQKQKHPKKVKQAFNPLI.
Q9WRN5_9GAMA/6-394 ..HYGARVDVDALGSISRVYDHIKGI.VK.KGVIQ......ISGQG.RAPVLSVLSSVGDAGVLGLRLK.NALAPLMVYS.......DMTDEVSFSFRN.TSLGNTFTHTREMFGVNIAEMNVAFYHHgdesDAEGKP..QFVRTTIAYGDNHT.STVHKSVVdEPNLPSFHDRLEQAGTGNRLFLTVKTLTLLLKWLRQQKTRA.kQVVTVSLSETLAVAT.FTVDGVSKIIDFKPDT....PDAKWTCARGRK-LDVGVVSSDLTTHVSLESLVAALNACKIPGFFLPGFRWHANEILEVEGLPL-TDSLADVRLGVMLLKVDPTDRNNAVP----........................GNLSEGADP..EGVPELPSPP...............................RTPDLDLKEQCVPIAEDGAEPTDGGAKS.LRT..SGSRpeKKHGKRkhssspSRGKGKTKTPRATFNPLF.
VG59_ALHV1/4-408 ..CASFRLSPALLTSSTKIYDHVKSH.LK.SAMIQ......FSDLN.TTPVMSIISNMGSAGIVTFQLT.GAVSDTETLA.......EITEP--LAFRN.HSFGGTYLHSREFFGKEIEDILVRFYKR....ASTASKlpEFVETKITYNNSIT.ETRHTSTV.DSHVSPVEKYLQKCFVKAKLILSIKTCTMLQKWLRQNKNKS..PVARLHINETLTVLV.VTVGDECTTIEFKSFV....LEPADAFLTLDKPGNFGAVLVDCTAVVNLECLIQAIGICKVPSVCVPAFKFYSGGIVEVSSAHLKQSKSPSATVSTVLLDASESLKQPAEQEQPT........................TSQPSDPQS..SNSVDKPSPPrpsisqpvrrrap.....praiisdseedsdSDSDQDCSTETQPETSYREEPKKFTPKP.-TA..PPNK..RKQFEP......-LKCPVEKKKKSNSNSFV.
VG59_SHV21/10-368 .s-YGVGFKPCVLQEHTKIYNHIKAK.VK.DGIIQ......IEGLT.SSPSLRIWSSIGE-GILSFKIN.NVVSEVFNCH.......MMPENVSVSFRNiSPGGNTFLYTRELFGCNVKTATLMFSNR....--SGKP.fEFIKAKLEYCDKVS.TTRHTSTI.PAGILPFVENVNSTSVLSRVVLSPKTAAMLQKWLREHKAH-..KTVSVMVNSTLAVLI.LTVEDSTKTVDLHIVD....----DMSLCNNPSKDWGVVQNDVQTKVNITALSAALGLCKIPGVFVPCIKFYESEVLEVCGTPVKLGSWVDTSLQVTLFCTPNLAEDTQ------........................AAVSDYFPI..SPSACLTADP...............................-------ADTQEEPTLSSNCQDSSVENS.PAL..PLKR..KREKDI......---NKKSKKIKIAFNPLI.
G1EUL5_BHV4/6-391 ..CYSANVKVPALTQNNKLYDHIKNN.LK.NGLIQ......LEGPS.SGPILSFLVNVGETGILVMKIK.DALEPMHEMDspqeedlNKSNNVSFSFRN.TSLGNTFVHSRELFGANVRDIYIVFYKR....ETSNVV..QFVRTTITYCDNET.NTTHKSVV.EAQAMPFIGKMETSEICSRVTLCPKTANALQKFLKQHKTKE.kRTVRVSINETLGVII.FTIGEDSKTIDFKMSD....-QQDLENIQTAKVEDVGHVNGDSVSYVSLESLTAALGCCKIPGCLTPCFRLYSSDILEVIGARLKGCTLGDSSISVILLKAEATEENNSTSIGNL........................DSISKNICE..NRGDKYPQPC...............................KDEARSPSTSVEEERPLTPSPPHCLSRP.PNP..TPVK..RRHADL......--KKKNHKKLRLSFTPLI.
Q918P2_9GAMA/4-389 ..CAVFTLCPAALGKAAKMYEHVKAH.LK.LAMIQ......ISDLH.TAPVLSIISNVGRAGILNFQLT.NAVISSDILT.......EVTEP--LAFRN.HSFGNTYLHSREFFGSNIEDIVVRFYKR....DSAEVPapEFVETRIAYNNGVT.ETRHTSTV.ERHISPVEKHLQKSFVEAKVILSIKTCTMLQKWLRQCKSAS..SYARLHVNETLGVWV.ITVGDECKTIEFKSHS....IEPADAFLSLDKPGNFGAVLVDCTAVVSLECLIHAISICKVPSVCVPAFKFYSGGIVEVASAHLKQSKNPAAVVSAVLLNAEDLAEKDPEVLPSTsghpp..............pspipQANLSDSEE..DTVDFSPPPP...............................--------TPTSPLESFILKPSAKEPRP.KSE..TPHK..RKQAEPs...ryKRPEKKAKKISNIFSSA-i
D0U1P8_MHV68/1-396 ..MQTFQLDTDRLWQAAKLYQHTKSD.FGvNGMIQ......LSGSC.NNMSLSILGSIGGCAILRLELL.-EAARLHSSK.......ESSKSAIYSFRNsSSLGREFTHGGELFGPKMESASLSFYGH....HGVRYVeaQFVH------DSSS.KTVHTAAM.QPITIPPSCAFDDREARGIVTMSTKTAAALVKWLKQHTKTC.qSPVKVSISEILSVMV.VSVGDASMTVDVAPVN....VSSGKKTRGGNRASDSGSISADATVHVNGHCLIRSLVVCKVPGCTTPRVKFHACGILEVDGAPVKQGELTQVKLSVALLNVDCTTGKVLKEPVVT........................GSSKDRVASasKSEDAASSPPiqdhh....................qgsltsDSDSSVPGPRSSDLSSLTRTPSDTFSSD.IRPgcGGQQflKRPPPK......KEKEPTPKRPKLHFNHF-p
EAD_EBVB9/4-404 ..TQTLRFKTKALAVLSKCYDHAQTH.LK.GGVLQv...nlLSVNY.GGPRLAAVANAGTAGLISFEVSpDAVAEWQNHQ......sPEEAPAAVSFRN.LAYGRTCVLGKELFGSAVEQASLQFYKR...pQGGSRP..EFVKLTMEYDDKVS.KSHHTCAL.MPYMPPASDRLRNEQMIGQVLLMPKTASSLQKWARQQGS--..GGVKVTLNPDLYVTT.YTSGEACLTLDYKPLS...vGPYEAFTGPVAKAQDVGAVEAHVVCSVAADSLAAALSLCRIPAVSVPILRFYRSGIIAVVAGLLTSAGDLPLDLSVILFNHASEEAAASTASEPEdkspr..............vqplgTGLQQRPRH..TVSPSPSPPPpp...........................rtPTWESPARPETPSPAIPSHSSNTALERP.LAV..QLAR..KRTSSE.....aRQKQKHPKKVKQAFNPLI.
#=GR EAD_EBVB9/4-404 SS ..EEEEEE-TTTCGGGHHHHHHHHHH.HT.TSEEEE...ESGGGTT.TS-EEEEEEEESTTEEEEEEE-GGGEEEEEE-S......-TTTS-SEEEEES.B-SSSSSBHHHHHT-TTEEEEEEEEEE-...SSS-SS-..-EEEEEEEETTSS-.EEEEEEE-.-S----GGGTCGGS-EEEEEE--HHHHHHHHHHHHHTTT--..SEEEEEEETTTTEEE.EEETTEEEEEE-EE-S...S-GGGSS-S-BSSTS-EEEESS-EEEEEEHHHHHHHHHHT-BTTTEEEEEEEETTSEEEEEEEEBTTS----EEEEEEE-----XXXXXXXXXXXXXXXXX..............XXXXXXXXXXXXXX..XXXXXXXXXXXX...........................XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXX..XXXX..XXXXXX.....XXXXXXXXXXXXXXXXXXX.
P88950_HHV8/6-396 ..HYGVRVDVTLLSKIRRVNEHIKSA.TK.TGVVQ......VHGSA.CTPTLSVLSSVGTAGVLGLRIK.NALTPLVGHT.......EGSGDVSFSFRN.TSVGSGFTHTRELFGANVLDAGIAFYRKgeacDTGAQP..QFVRTTISYGDNLT.STVHKSVVdQKGILPFHDRMEAGGRTTRLLLCGKTGAFLLKWLRQQKTKE.dQTVTVSVSETLSIVT.FSLGGVSKIIDFKPET...kPVSGWDGLKGKKSVDVGVVHTDALSRVSLESLIAALRLCKVPGWFTPGLIWHSNEILEVEGVPT-GCQSGDVKLSVLLLEVNRSVSAEGGESSQKv......................pDSIPDSRRQ..PELESPDSPPl............................tpVGPFGPLEDASEDAASVTSCPPAAPTKD.STK..RPHK..RR-SDS......SQSRDRGKVPKTTFNPLI.
Q77NI0_9GAMA/6-394 ..HYGARVDVDALGSISRVYDHIKGI.VK.KGVIQ......ISGQG.RAPVLSVLSSVGDAGVLGLRLK.NALAPLMVYS.......DMTDEVSFSFRN.TSLGNTFTHTREMFGVNIAEMNVAFYHHgdesDAEGKP..QFVRTTIAYGDNHT.STVHKSVVdEPNLPSFHDRLEQAGTGNRLFLTVKTLTLLLKWLRQQKTRA.kQVVTVSLSETLAVAT.FTVDGVSKIIDFKPDT....PDAKWTCARGRK-LDVGVVSSDLTTHVSLESLVAALNACKIPGFFLPGFRWHANEILEVEGLPL-TDSLADVRLGVMLLKVDPTDRNNAVP----........................GNLSEGADP..EGVPELPSPP...............................RTPDLDLKEQCVPIAEDGAEPTDGGAKS.LRT..SGSRpeKKHGKRkhssspSRGKGKTKTPRATFNPLF.
E9M5P2_9GAMA/2-421 qr--TFEINTATLAAVAKVYNHVKGSaCN.DGAIQ......VSGCA.DNLNLTYVGAVGPGGVLRLDIL.DAVRQQYPCE......lETPQPCLFSFLNrTCLGRDFSHAGQMFGPQLKSMTLSFYTR....---EET..QYVESKFVY-DETS.KTVHTSAI.SNLHLPAIRQLGSGQLVGTIFLTTKTTMAMIKWLKESVATI.qENIKICLNEVLNIMV.ISTQKGSKTFEYAPRNlvgeSVPPKKGKGGTKMCDYGEVMEDLETWVNGHSFIRALHICKIPGMCLPALKFHSSGILDVAGENISPASKFSLLVSVV--KTDHSEDQPVPKPESEakpltpgsseegpvprhsqqrthaR--------..---------PlsdlssdessdeecsgvasatpacrgassgsNQHQPTPLSPVAEEASQPQTPKRCLLQQdVPS..APL-..KRKPHR......-PAKLDIKKPRLKFNPLV.
Q80BM1_SHV2/10-371 .s-YGVGFKPCVLQEHTKIYNHIKAK.VK.DGIIQ......IEGLT.SSPSLRIWSSIGE-GILSFKIN.NVVSEVFNCH.......MMPENVSVSFRNiSPGGNTFLYTRELFGCNVKTATLMFSNR....--AGKP.fEFIKAKLEYCDKVS.ATRHTSTI.PVGILPFVENVNSTGVLSRVVLSPKTAAMLQKWLREHKAH-..KTVSVMVNSTLAVLI.LTVEDSTKTVDLHIVD....----DMSLCNNLSKDWGVVQNDVQTKVNITALSAALGLCKIPGVFVPCIKFYESEVLEVCGMPVKLGSWVDTYLQVTLFCTPNLVEDTQ------........................AAGSDYVPI..SPSACLTADS...............................----ADLGATPEEPTLSSNCQDSSVENS.PAL..LLKR..KREKDI......---NKKSKKIKLAFNPLI.
Q8UZI4_9GAMA/4-404 ..TQTLRFKTKALAVLSKCYDHAQTH.LK.GGVLQv...nlLSVSYgGCPRLAAVANAGTAGLISFEVSpDAVAEWQDHQ......gSEEAPAALSFRN.LAYGRTCVLGKELFGSAVQQASLQFYKR...sQGGSRP..EFVKLTMDYDDNGCpRAHHTCAL.MPYMPPATDRLRNEHLIGQVLLMPKTAASLQKWARRHGT--..GGVKVTLNPDLYVTT.YTSGEACLTLDYKPLS...vGPSEAFTGPVIKAQDTGAVEAHVTCSVAADSLAAALGLCRIPAVSVPILRFYRSGIIAVAAGLLASAGDLPLELSVILFNHDSEEADTSTPTEPEakspa..............pqplgAELHQRPRH..TVSPSPSPPPp............................rtPTWESPARPETPPPAKPSHS-NAAPERP.LAV..QLAR..KRTSSE.....aRQKQKHPKKVKQAFNPLI.
VG59_EHV2/8-414 ..THCMALNVENFKACAKIHNHVKNY.LK.KGLVQ......IVGFE.TEPVFQIMATACDGGILVFKVL.NPFESFNVSY.......SRMETLSLSFKN.QPHGNTYLYSKDLFGEAVKGASLTFLQR....PGLCRP..DFVRSDVLMDDDVT.TSSHCTSL.TSWSPPAHD-IRAGTVMSKVVLSIKTCTMLQKWLKDQKSKGepRCVRLCLNEILSVLV.LSVGEASKTVHLKPVE....GNPATSLLFADKQGDVCIISDDEAHDVSLDSLLAALGVCRIPALCLPCFNFHSNGVLEVVGLQFKSSKPASGELSVFLLRANPQVDFNGVPEGDVqt...................qevSSVASTCRH..LSESCSLDPPrtpelpgspdtfk.....eipgrsgsvhlerDLSCSDSEEETPKQKPAKAKPAAAPKRS.---..-EKR..KREGGK......--KGPKAKSLKLTFNPLI.
Q2VSI2_9GAMA/4-389 ..CAVFTLCPAALGKAAKMYEHVKAH.LK.LAMIQ......ISDLH.TAPVLSIISNVGRAGILNFQLT.NAVISSDILT.......EVTEP--LAFRN.HSFGNTYLHSREFFGSNIEDIVVRFYKR....DSAEVPapEFVETRIAYNNGVT.ETRHTSTV.ERHISPVEKHLQKSFVEAKVILSIKTCTMLQKWLRQCKSAS..SYARLHVNETLGVWV.ITVGDECKTIEFKSHS....IEPADAFLSLDKPGNFGAVLVDCTAVVNLECLIHAISICKVPSVCVPAFKFYSGGIVEVASAHLKQSKNPAAVVSAVLLNAEDLAEKDPEVLPSTsghpp..............pspisQANLSDSEE..DTVDFSPPPP...............................--------TPTSPLESFILKPSAKEPRP.KSE..TPHK..RKQAEPs...ryKRPEKKAKKISNIFSSA-i
Q99CY3_BHV4/6-391 ..CYSANVKVPALTQNNKLYDHIKNN.LK.NGLIQ......LEGPS.SGPILSFLVNVGETGILVMKIK.DALEPMHEMDspqeedlNKTNNVSFSFRN.TSLGNTFVHSRELFGANVRDIYIVFYKR....ETSNVV..QFVRTTITYCDNET.NTTHKSVV.EAQAMPFIGKMETSEICSRVTLCPKTANALQKFLKQHKTKE.kRTVRVSINETLGVII.FTIGEDSKTIDFKMSD....-QQDLENIQTAKVEDVGHVNGDSVSYVSLESLTAALGCCKIPGCLTPCFRLYSSDILEVIGARLKGCTLGDASISVILLKAESTEENNSTSIGNL........................DSISKNICE..NRGDKYPQPC...............................KDEARSPSTSVEEERPLTPSPPHCLSRP.PNP..TPVK..RRHADL......--KKKNHKKLRLSFTPLI.
Q53CV4_9GAMA/6-394 ..HYGARVDVDALGNISKVYDHIKGI.VK.KGVIQ......ISGQG.RAPVLSVLSSVGDAGVLGLRLK.NALAPLMVYS.......DMTDEVSFSFRN.TSLGNTFTHTREMFGVNITEMNVAFYHHgdesNAEGKP..QFVRTTIAYGDNHT.STVHKSVVdEPNLPSFHDRLEQAGTGNRLFLTVKTLTLLSKWLRQQKTRA.kQVVTVSLSETLAVAT.FTVDGVSKIIDFKPDT....PDAKWTCAKGRK-LDVGVVSSDLTTHVSLESLVAALNACKIPGFFLPGFRWHANEILEVEGLPL-TDSLADVKLGVMLLKVDPTDRNNAVP----........................GNLSEGADP..EGVPELPSPP...............................RTPDLDLKEQCVPNAEDGTEPTDGGAKS.LRT..SGSRpeKKHGKRkhssspSRGKAKTKTPRATFNPLF.
G3CKQ3_EBVG/4-404 ..TQTLRFKTKALAVLSKCYDHAQTH.LK.GGVLQv...nlLSVNY.GGPRLAAVANAGTAGLISFEVSpDAVAEWQNHQ......sPEEAPAAVSFRN.LAYGRTCVLGKELFGSAVEQTSLQFYKR...pQGGSRP..EFVKLTMEYDDKVS.KSHHTCAL.MPYMPPASDRLRNEQMIGQVLLMPKTASSLQKWARQQGS--..GGVKVTLNPDLYVTT.YTSGEACLTLDYKPLS...vGPYEAFTGPVAKAQDVGAVEAHVVCSVAADSLAAALSLCRIPAVSVPILRFYRSGIIAVVAGLLTSAGDLPLDLSVILFNHASEEAAASTASEPEdkspr..............vqplgTGLQQRPRH..TVSPSPSPPPpp...........................rtPTWESPARPETPSPAIPSHSSNTALERP.LAV..QLAR..KRTSSE.....aRQKQKHPKKVKQAFNPLI.
#=GC SS_cons ..EEEEEE-CCCCHHHHHHHHHHHHH.HT.TSEEEE...ESCCCCT.TSEEEEEEEEETTTEEEEEEESGCGEEEECC-T......-TTTSECEEEEES.B-TTSSSBHHHHHT-TTEEEEEEEEEE-...SSS-SS-..-EEEEEEEETTTT-.EEEEEEE-.-TTS--GCCTCGCSTCEEEEE--HHHHHHHHHHHHCTTTSS..SEEEEEEETTTTEEE.EEETTEEEEEE-EE-S...S-GCCTCTTBBTTTS-EEEESS-EEEEEEHHHHHHHHHHT-BTTTEEEEEEEETTSEEEEEEEECTTSTTTTEEEEEEE-----XXXXXXXXXXXXXXXXX..............XXXXXXXXXXXXXX..XXXXXXXXXXXX...........................XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXX..XXXX..XXXXXX.....XXXXXXXXXXXXXXXXXXX.
#=GC seq_cons ..phshplcsssLuphuKlY-HlKup.lK.sGlIQ......lsGss.ssPsLulluslGsuGlLshclp.sAluphhspp.......ptspssuhSFRN.puhGsTFlaoRELFGssVcsssltFY+R....psuupP..pFV+splpYsDsso.pTpHTSsl.pshh.Php-+lcssthhu+VlLssKTushLQKWLRQp+op...psV+VolNEsLuVhs.hTlG-soKTlDaKPhs....ss.tttshsssKstDsGsVpsDssspVul-SLhAALulCKIPGshlPsl+FauusILEVsGs.lpsus.sslcLSVlLhpssspspssus...s.........................sulpppspp..ssssssssPP................................s.tts.psposs.u.sopsPssshp+s..ss..p.p+..KRpucp......pppcc+sKKsKhsFNPLI.
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