#=GF ID Herpes_LMP1
#=GF AC PF05297.15
#=GF DE Herpesvirus latent membrane protein 1 (LMP1)
#=GF AU Moxon SJ;0000-0003-4644-1816
#=GF SE Pfam-B_5174 (release 7.7)
#=GF GA 26.00 26.00;
#=GF TC 26.40 26.90;
#=GF NC 25.30 25.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 12457963
#=GF RT Characterization of the Cyno-EBV LMP1 homologue and comparison
#=GF RT with LMP1s of EBV and other EBV-like viruses.
#=GF RA Faucher S, Dimock K, Wright KE;
#=GF RL Virus Res 2002;90:63-75.
#=GF DR INTERPRO; IPR007961;
#=GF DR SCOP; 1czy; fa;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family consists of several latent membrane protein 1 or
#=GF CC LMP1s mostly from Epstein-Barr virus. LMP1 of EBV is a 62-65 kDa
#=GF CC plasma membrane protein possessing six membrane spanning
#=GF CC regions, a short cytoplasmic N-terminus and a long cytoplasmic
#=GF CC carboxy tail of 200 amino acids. EBV latent membrane protein 1
#=GF CC (LMP1) is essential for EBV-mediated transformation and has been
#=GF CC associated with several cases of malignancies. EBV-like viruses
#=GF CC in Cynomolgus monkeys (Macaca fascicularis) have been associated
#=GF CC with high lymphoma rates in immunosuppressed monkeys [1]
#=GF SQ 7
#=GS A0A1Q9DPX0_SYMMI/1682-1974 AC A0A1Q9DPX0.1
#=GS LMP1_EBVA8/1-371 AC Q1HVB3.1
#=GS Q66043_9GAMA/1-402 AC Q66043.2
#=GS A0A6L5QSJ0_9GAMM/3-215 AC A0A6L5QSJ0.1
#=GS A0A177CY40_9PLEO/5-202 AC A0A177CY40.1
#=GS LMP1_EBVB9/1-386 AC P03230.1
#=GS A0A1Q9DVU0_SYMMI/217-550 AC A0A1Q9DVU0.1
A0A1Q9DPX0_SYMMI/1682-1974 eeteeagpptpdchqaptplrpssgnasrklredltkvaapsmssgasycccrragt-------------------------------------------------------SSSTVVLVVVVVVV...VVVVVVVVVVVVVL..VLVLVLVLVLVLVLVLVLVLV....LVLVLVLVLVLVLVLVLVLVLVLVLVL...VLVL..VLVLVLVLVLVLVLVLV-LV..LVL.VLV..LVL.....VLVLVLVLVLVLVLVLVLVL...HDHDHDHD........HDHDHDHDHDHDHAVVLY.RNED.....GEDQVD...EE.RQEA.ALSPASKT.P-------...------------------------------------------------------------------------......---------------.----------------------------.-------....----------------------salllaaydeieeiqevadasdadagpspvaeepaepseveealedgikeggpgqpl
LMP1_EBVA8/1-371 .........................................................MEHDLERGPPGPRRPPRGPPLSSSLGLALLLLLLALLFWLYIVMSDWTGGALLVLYSFALILIIIILII...FIFRRDLLCPLGAL..CLLLLMITLLLIALWNLHGQA....LYLGIVLFIFGCLLVLGLWIYLLEILW...RLGA..TIWQLLAFFLAFFLDLILLI..IAL.YLQ..QNW.....WTLLVDLLWLLLFLAILIWM...YYHGQRHS........DEHHHDDSLPHPQQATDD.SGHE.....SDSNSN...EG.RHHL.LVTGAGDG.PPLCSQNL...GAPGGGPDNGPQDPDNTDDNGPQDPDNTDDNG-----PQDPDNTDDNGPQDPDNTADNGPHDPLPHNPSDSA......GNDGGPPNLTEEVEN.KGGDRGPPSMTDG----------GGGDP.HLPTLLL....GTSGSGGDDDDPHGPVQLSYYD.........................................................
Q66043_9GAMA/1-402 ......................................................meg-----NRGRGGGHRHPRCPQPHASLLFGSLLLLVAILVWFFIIMSDLTQTASTVLSSFAVVLIIIIIII...MLFKRRLLCPLGLL..CIILIMIVILVSNLLTLTGQT....LFVGLVILCLCILLALAVWFYLMWLLR...EYGA..SFWTILAFCLAFLLAIVFLI..IAV.LLH..LAW.....FTVLVDLYWLLLFLAILIWI...YVHDFNRAipealanlEEEYNHQGHGHGGGQGDE.HQPRvllisEDPKTHhhhHH.HHHH.KNSNQGDPlGPYVSQNG...GNGGNEGDGGNRDGGNGD-GGNGDGGNVGDGGNGNGGNGDGGNGDG-GNGDGGN--EGPDHLPYPIQATDGGnggegdGGNEGPDPLPYPIQAtDGGNGGQGDGGDGDGGNGGNGG-GGGDPdHLPHPIQatdgGNSGDGGDGGD-----------gedge....................................................
A0A6L5QSJ0_9GAMM/3-215 ..........................................nllkslfislasvfa---------------------------------------------------------------------...--------------..-----------FVVSILAIQQ....LFLGFNLTWLGTLVAAAPFALLLSWLF...LIGTarTSANLMMMLEVSIIGLIVSV..VGF.ILHdlNDY.....WALVLSITATLSALAYIFWY...SKFNQRDC........SKLAVGKQLPNVEL-ADI.NGQP.....INTDSF...KG.KKTL.MIFYRGNW.CPLCMVQI...K-----------------------------------------------------------------------......---------------.----------------------------.-------....----------------------elassyqklaesgvrialvspqspkhtqslakkfevpfeyyidrnn...........
A0A177CY40_9PLEO/5-202 ......................................................tie---------------------------------------------------------------------...--WRRRVLLPLWAIriCLLLVIVIGFSVAMGSNYDDArriiRYPAAVAFLFFTIVVLLLDVIQ-IILWtrdRLYP..TYFAGLTIFQALFWGLVLLMdiVSIaNSQ..QSS.....RAVSLVVVIFLLYLGLFIYAlrgFLKQRRLS........KQGHYTPANDAGAPAVAEiRYSE.....STFDRN...DE.QHHS.PIYRGGD-.--------...------------------------------------------------------------------------......---------------.----------------------------.-------....----------------------lgeseplyaedeglvdry.......................................
LMP1_EBVB9/1-386 .........................................................MEHDLERGPPGPRRPPRGPPLSSSLGLALLLLLLALLFWLYIVMSDWTGGALLVLYSFALMLIIIILII...FIFRRDLLCPLGAL..CILLLMITLLLIALWNLHGQA....LFLGIVLFIFGCLLVLGIWIYLLEMLW...RLGA..TIWQLLAFFLAFFLDLILLI..IAL.YLQ..QNW.....WTLLVDLLWLLLFLAILIWM...YYHGQRHS........DEHHHDDSLPHPQQATDD.SGHE.....SDSNSN...EG.RHHL.LVSGAGDG.PPLCSQNL...GAPGGGPDNGPQDPDNTDDNGPQDPDNTDDNGPHDPLPQDPDNTDDNGPQDPDNTDDNGPHDPLPHSPSDSA......GNDGGPPQLTEEVEN.KGGDQGPPLMTDGGGGHSHDSGHGGGDP.HLPTLLL....GSSGSGGDDDDPHGPVQLSYYD.........................................................
A0A1Q9DVU0_SYMMI/217-550 .........................................phliitiiitiaifvt-----------------------------------------------------VFFFFFFIIIIIIIIVsvtVIVTITRNATTTTI..LLLLLIIIIIIIIFTFIILTF....TFIIIVIVIVIVIVIVIINIIIICYLI...ITAI..AINTIITIIIVIIIIIIIII..VFF.FFF..FIFgfsfiFIVFVIIIVISMVLAAVVVV...AIEEVKSD........DTERKVRKHCHPGHRCSG.NLHA.....RSRPTG...EAwQFHTyLQEKEKDK.KKKKKSKSssdDSDSSEEDKKKKKADSSDDN---DSDDDDDEKEKEKSKEKADKDDESKSDDVEEVKPEDPSKKLEEEA----......---------------.----------------------------.-------....----------------------rkkaakaaeeaqaaaaklaaekaeaaarqkqresltkaaasaasaataaaa......
#=GC seq_cons ......................................................h.t..........................................................hhhllllllll...hlhphpllsslssl..sllLlhlhllllslh.lhsps....LalulVlhlhhsLlllhlhlhll.hLh...hlus..ohhplLshhlshhlsLllLl..lul.hLp...sa.....asllVsllhlLLhLAlllah...ah+sp+cs........ccccpscshsHstttsst.ptpc.....psssos...-t.++Hh.hlpttGDh.s.hh..p....t....................................................................................................................................................................................................................
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