GenomeNet

Database: Pfam
Entry: Herpes_TAF50
LinkDB: Herpes_TAF50
Original site: Herpes_TAF50 
#=GF ID   Herpes_TAF50
#=GF AC   PF03326.12
#=GF DE   Herpesvirus transcription activation factor (transactivator)
#=GF AU   Mifsud W
#=GF SE   Pfam-B_3658 (release 6.5)
#=GF GA   19.70 19.70;
#=GF TC   19.70 20.10;
#=GF NC   19.30 19.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10559285
#=GF RT   The activation domain of herpesvirus saimiri R protein interacts
#=GF RT   with the TATA-binding protein. 
#=GF RA   Hall KT, Stevenson AJ, Goodwin DJ, Gibson PC, Markham AF,
#=GF RA   Whitehouse A; 
#=GF RL   J Virol 1999;73:9756-9763.
#=GF DR   INTERPRO; IPR004998;
#=GF CC   This family includes EBV BRLF1 and similar ORF 50 proteins from
#=GF CC   other herpesviruses.
#=GF SQ   10
#=GS RTA_EBVA8/369-590       AC Q1HVG0.1
#=GS D9QL74_BRESC/1-79       AC D9QL74.1
#=GS RTA_EBVB9/81-372        AC P03209.1
#=GS BRLF1_EHV2/88-643       AC Q66652.2
#=GS ORF50_HHV8P/85-651      AC F5HCV3.1
#=GS RTA_EBVA8/81-372        AC Q1HVG0.1
#=GS BRLF1_SHV21/101-330     AC Q01012.1
#=GS A0A0R3WWV2_HYDTA/3-137  AC A0A0R3WWV2.1
#=GS RTA_EBVB9/369-590       AC P03209.1
#=GS BRLF1_ALHV1/105-619     AC O36398.1
RTA_EBVA8/369-590                  ......q-----------------------------------------------------------------------------------------------------------------------------------....-----------------------....------------.----------------------------------------......-----------------...-------.........-----------..................---.........---------------------------------.....-----------------------........-----------------------------------T.PCPSNAE-------EPEQPWIAAVHQESDERPIFPHPSKPTFLPPVKRK---KGLRDSREGMFLPKPEAGSAISDVFEGREVCQPKRIRPFHPPGSPWAN.....RPLPASLAPTP.TGPVHEPVGSLTPAPVP.RPLDPAPAVTPE...ASHLLEDPDEETSQavkalremadtviPQKEEAAICGQMD.LNHPPPRGHLDELTTTLESMTEDLNLDSPLT....PELNEILDTFLND------------........---------ecllha............................
D9QL74_BRESC/1-79                  ....mkk-----------------------------------------------------------------------------------------------------------------------------------....-----------------------....------------.----------------------------------------......-----------------...-------.........-----------..................---.........---------------------------------.....-----------------------........-----------LIVAGALALTALAAAGCGRMADLET.PGPRETERAPRDARAPDLPDPATVNRPSSQIPIDGGPSNP-FGSPAAARD--------------------------------------------------.....-----------.-----------------.------------...--------------.............-------------.-------------------------------....-------------------------........---------pr................................
RTA_EBVB9/81-372                   .......ILRNNRVRRRAENAGNDACSIACPIVMRYVLDHLIVVTDRFFIQAPSNRVMIPATIGTAMYKLLKHSRVRAYTYSKVLGVDRAAIMASGKQVVEHLNRMEKEGLLSSKFKAFCKWVFTYPVLEEMFQTM--....VSSKTGHLTDDVKDVRALIKTLP....RASYSSHAGQRSyVSGVLPACLLSTKSKAVETPILVSGADRMDEELMGNDGGAshtearYSESGQFHAFTDELESL...-------.........--PSPTMP---..................LKPgaqsadcgdSSSSSSDSGNSDTEQSEREEARAEAPRLRAPK-.....SRRTSRPNRGQT-----------........------------------------------------.----------------------------------------------------------------------------------------------------.....-----------.-----------------.------------...--------------.............-------------.-------------------------------....-------------------------........---------pc................................
BRLF1_EHV2/88-643                  .......LFRNYKNKQSAESANTNPCALMAQQFLKFHTERLLVCTDRFFSTGCCSQINMPYDLCQHVFKFQQDLRKRCIASWKTLSGGRRAFMTVVQDIFTCFTTLRANELITPRQQAFFKLSYPPCRVQNVINILNVvhtqGIKDLKSLN-----MQKIKKRTP....HAGIFSASGQPL.FP--IPEALLVDFNG---EGIIRSDIADVSPFLQNPEEFL......---ATDFFTYIKRFQGVgvqIRDPEPR.........YQPASQQPQQA..................LRP.........-------------QQQVLQQATAYPASVQAGGF.....AIQTESPMEGTSAQYFLAAQQHG........VVGLFPSTATLVPIAGSTGVTEVVSYGHNSTSPVSTfSAPSTSVTEADHQTQPRRSRKATAKRKHQQVQDGNEDEGPQRHPQAHSRQFFQG-----AASHQTAQPAQVLQQSVIHGTQGALYFMGPAQQIPGDHSQIpvisnAMLQSVLQQQGgSGAAIYDLSQLQPCVVPvQQQAAQEVAVPT...AVIHYQPAMQPQPQ.............PYQQQQFLQPQQQ.AQTPSPQMQQRQLTPQSSPEPADEEEEGPLNlttrTEDHEILEEILSNLYPEERRQQEQQ........HQQGEEAAP..................................
ORF50_HHV8P/85-651                 .......FFRASRMRTKGAAGYNVPCAEASQGIIRILTERILFCTEKAFLTAACSGVSLPPAICKLLHEIYTEMKAKCLGAWRRLVCNRRPIMILTSSLLKLYNTYDTAGLLSEQSRALCLLVFQPVYLPRIMAPLEI....MTKGQLAPENFYSITGSAEKRRPittgKVTGLSYPG---.-SGLMPESLIL---PILEPGLLPASMVDLSDVLAKPAVIL......SAPALSQFV--------...ISKPHPNmphtvsiipFNPSGTDPAFIstwqaasqnmvyntstapLKP.........ATGSSQTVSVKAVAQGAVITATTVPQAMPARGTggelpVMSASTPARDQVAACFVAENTGDspdnpssfLTSCHPCDPNTVIVAQQFQPPQCVTLLQVTCAPSST.PPPDSTVRAPVVQLPTVVPLPASAFLPALAQPEASGEELP------GGHDGDQGVPCRDSTAAATAAEATTPKRK--QRSKERSSKKRKALTVPEADT--.....-----------.TPSTTTPGTSLGSITTP.QDVHATDVATSE...GPSEAQPPLLSLPP.............PLDVDQSLFALLD.EAGP-----------------ETWDVGSPLS....PTDDALLSSILQGLYQLDTPPPLRSpspasfgpESPADIPSP..................................
RTA_EBVA8/81-372                   .......ILRNNRVRRRAENAGNDACSIACPIVMRYVLDHLIVVTDRFFIQAPSNRVMIPATIGTAMYKLLKHSRVRAYTYSKVLGVDRAAIMASGKQVVEHLNRMEKEGLLSSKFKAFCKWVFTYPVLEEMFQTM--....VSSKTGHLTDDVKDVRALIKTLP....RASYSSHAGQRSyVSGVLPACLLSTKSKAVETPILVSGADRMDEELMGNDGGAshtearYSESGQFHAFTDELESL...-------.........--PSPTMP---..................LKPgaqsadcgdSSSSSSDSGNSDTEQSEREEARAEAPRLRAPK-.....SRRTSRPNRGQT-----------........------------------------------------.----------------------------------------------------------------------------------------------------.....-----------.-----------------.------------...--------------.............-------------.-------------------------------....-------------------------........---------pc................................
BRLF1_SHV21/101-330                .......LLRNYKTKQRSQPVNSTVVSRYAHHVVKYIMQRLVYTTDRLFLTAPTSGIVLPVPLANAIFNLLSHCRKKCTGLWRNYGTEKSVLMGLGKEITLCYQALNESGIVSTTLAAFIKLSFPTISIPNLFKPMFQ....SCKGNQDNFPDIC-TQGSVIRRP....HQGVFGDT----.FP--IPDPLMR---EISENSFKKFSTANISTLLQNPKEIL......-----------------...-------.........-----------..................---.........---------------------------------.....-----------------------........------------------------------------.----------------------------------------------------------------------------------------------------.....-----------.-----------------.------------...--------------.............-------------.-------------------------------....-------------------------........---------emdpfdpriggfplnkeetatplkdssfsnptfi
A0A0R3WWV2_HYDTA/3-137             sevhhld-----------------------------------------------------------------------------------------------------------------------------------....-----------------------....------------.----------------------------------------......-----------------...-------.........-----------..................---.........---------------------------------.....-----------------------........------------------------------------.----------------------------------------------------------------------------------------------------.....----SLVIQHI.GVYTVCPVSSLTSFTEP.SESHTQEIIKLSsflGSSPHQAIASARPD.............SQSNHQRLYKCITtSSVPTVESQRGKSASSPAVISGDKDVVAPTG....EKLHTLCSQFLTSLYQPQRPPE---........---------fwekcvss..........................
RTA_EBVB9/369-590                  ......q-----------------------------------------------------------------------------------------------------------------------------------....-----------------------....------------.----------------------------------------......-----------------...-------.........-----------..................---.........---------------------------------.....-----------------------........-----------------------------------T.PCPSNAA-------EPEQPWIAAVHQESDERPIFPHPSKPTFLPPVKRK---KGLRDSREGMFLPKPEAGSAISDVFEGREVCQPKRIRPFHPPGSPWAN.....RPLPASLAPTP.TGPVHEPVGSLTPAPVP.QPLDPAPAVTPE...ASHLLEDPDEETSQavkalremadtviPQKEEAAICGQMD.LSHPPPRGHLDELTTTLESMTEDLNLDSPLT....PELNEILDTFLND------------........---------ecllha............................
BRLF1_ALHV1/105-619                .......LFRSYKQRVRTHFGKQLLCATASSQIIRFFLERVIRHTDKWFLLAPCNGLILPQELAKEMYVLLSEARGKALNQGRMFSGGRQNMMNAAKKVLTVYSSLRDDGEISPEVKAYMAYIFPVPDIEQVFQPLFKleqeIRKGKATLT--QSLLFAPRKRCP....NKTVFSQYGARQ.-RYVLPEVLLEASEP---QSTLAYGCPDISSLLRDSSSTQentdeeSGPCCS--------KTLspgVPQPQSE.........YDPSPTSPPDSdtes..........cdsqVRPes.....tdSDTHAEDDDVPEAPQAASQTQPTTTQETQS---.....CCSVYNPATTQTGFYYNQQSSDN........FAS---------------------RIDASATSTSYGyPGPVTNHGFSTSVFSHTVPTTATGQQQLHQNMYGGGQQTTTYGSYVGGYSDANGQSVGASTSYYTSKPATSRSSTALQWT---------TLFPPASSS--.....--ASSSQVSDYfSGFPYFPGSS----TVP.QAFEPLAPSTPS...LLDE----------.............LLDRDSGLVSQQQ.APAPPQNDQGGPPQYVPVAQEQQQSSTDPLS....DEMRRIFEFF---------------........---------dsvnpvtrp.........................
#=GC seq_cons                      .......hhRs.+.+.pst.s.p..su.hs..hh+hhhp+llhhT-+hF..ussstl.hP..lsp.ha.h.pc.+h+shs..+.hsst+tshM..spplh.hhpthpttt.lo.p.tAhhhh.a....l.phht.h........pt..t.......h.t..hphP....p.sh.u...........hPtsLh.........shh..shsphs..L.tst.h............................................................................................................................................................................................s.ssP.ps............s..Ass.....t....st.p.s......tth....................................................................ss.sh.shsp....s.P.p..ts....h.p...h............................p.pt.l....p...hP.................tp.p..sPhs.....p.ptlhp.h.................................p................................
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