GenomeNet

Database: Pfam
Entry: Herpes_TAF50
LinkDB: Herpes_TAF50
Original site: Herpes_TAF50 
#=GF ID   Herpes_TAF50
#=GF AC   PF03326.11
#=GF DE   Herpesvirus transcription activation factor (transactivator)
#=GF AU   Mifsud W
#=GF SE   Pfam-B_3658 (release 6.5)
#=GF GA   19.70 19.70;
#=GF TC   19.70 20.60;
#=GF NC   19.30 19.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10559285
#=GF RT   The activation domain of herpesvirus saimiri R protein interacts
#=GF RT   with the TATA-binding protein. 
#=GF RA   Hall KT, Stevenson AJ, Goodwin DJ, Gibson PC, Markham AF,
#=GF RA   Whitehouse A; 
#=GF RL   J Virol 1999;73:9756-9763.
#=GF DR   INTERPRO; IPR004998;
#=GF CC   This family includes EBV BRLF1 and similar ORF 50 proteins from
#=GF CC   other herpesviruses.
#=GF SQ   9
#=GS D9QL74_BRESC/1-79    AC D9QL74.1
#=GS RTA_EBVA8/369-590    AC Q1HVG0.1
#=GS RTA_EBVB9/81-372     AC P03209.1
#=GS BRLF1_EHV2/88-643    AC Q66652.2
#=GS ORF50_HHV8P/85-651   AC F5HCV3.1
#=GS RTA_EBVA8/81-372     AC Q1HVG0.1
#=GS BRLF1_SHV21/101-330  AC Q01012.1
#=GS RTA_EBVB9/369-590    AC P03209.1
#=GS BRLF1_ALHV1/105-619  AC O36398.1
D9QL74_BRESC/1-79               mkk-----------------------------------------------------------------------------------------------------------------------------------....-----------------------....------------.----------------------------------------......-----------------...-------.........-----------..................---.........---------------------------------.....-----------------------........-----------LIVAGALALTALAAAGCGRMADLET.PGPRETERAPRDARAPDLPDPATVNRPSSQIPIDGGPSNP-FGSPAAARD--------------------------------------------------.....-----------.-----------------.--------------------------.............--------------------------------------------....-------------------------........---------pr................................
RTA_EBVA8/369-590               ..q-----------------------------------------------------------------------------------------------------------------------------------....-----------------------....------------.----------------------------------------......-----------------...-------.........-----------..................---.........---------------------------------.....-----------------------........-----------------------------------T.PCPSNAE-------EPEQPWIAAVHQESDERPIFPHPSKPTFLPPVKRK---KGLRDSREGMFLPKPEAGSAISDVFEGREVCQPKRIRPFHPPGSPWAN.....RPLPASLAPTP.TGPVHEPVGSLTPAPVP.RPLDPAPAVTPEASHLLEDPDEETSQavkalremadtviPQKEEAAICGQMDLNHPPPRGHLDELTTTLESMTEDLNLDSPLT....PELNEILDTFLND------------........---------ecllha............................
RTA_EBVB9/81-372                ...ILRNNRVRRRAENAGNDACSIACPIVMRYVLDHLIVVTDRFFIQAPSNRVMIPATIGTAMYKLLKHSRVRAYTYSKVLGVDRAAIMASGKQVVEHLNRMEKEGLLSSKFKAFCKWVFTYPVLEEMFQTM--....VSSKTGHLTDDVKDVRALIKTLP....RASYSSHAGQRSyVSGVLPACLLSTKSKAVETPILVSGADRMDEELMGNDGGAshtearYSESGQFHAFTDELESL...-------.........--PSPTMP---..................LKPgaqsadcgdSSSSSSDSGNSDTEQSEREEARAEAPRLRAPK-.....SRRTSRPNRGQT-----------........------------------------------------.----------------------------------------------------------------------------------------------------.....-----------.-----------------.--------------------------.............--------------------------------------------....-------------------------........---------pc................................
BRLF1_EHV2/88-643               ...LFRNYKNKQSAESANTNPCALMAQQFLKFHTERLLVCTDRFFSTGCCSQINMPYDLCQHVFKFQQDLRKRCIASWKTLSGGRRAFMTVVQDIFTCFTTLRANELITPRQQAFFKLSYPPCRVQNVINILNVvhtqGIKDLKSLN-----MQKIKKRTP....HAGIFSASGQPL.FP--IPEALLVDFNG---EGIIRSDIADVSPFLQNPEEFL......---ATDFFTYIKRFQGVgvqIRDPEPR.........YQPASQQPQQA..................LRP.........-------------QQQVLQQATAYPASVQAGGF.....AIQTESPMEGTSAQYFLAAQQHG........VVGLFPSTATLVPIAGSTGVTEVVSYGHNSTSPVSTfSAPSTSVTEADHQTQPRRSRKATAKRKHQQVQDGNEDEGPQRHPQAHSRQFFQG-----AASHQTAQPAQVLQQSVIHGTQGALYFMGPAQQIPGDHSQIpvisnAMLQSVLQQQGgSGAAIYDLSQLQPCVVPvQQQAAQEVAVPTAVIHYQPAMQPQPQ.............PYQQQQFLQPQQQAQTPSPQMQQRQLTPQSSPEPADEEEEGPLNlttrTEDHEILEEILSNLYPEERRQQEQQ........HQQGEEAAP..................................
ORF50_HHV8P/85-651              ...FFRASRMRTKGAAGYNVPCAEASQGIIRILTERILFCTEKAFLTAACSGVSLPPAICKLLHEIYTEMKAKCLGAWRRLVCNRRPIMILTSSLLKLYNTYDTAGLLSEQSRALCLLVFQPVYLPRIMAPLEI....MTKGQLAPENFYSITGSAEKRRPittgKVTGLSYPG---.-SGLMPESLIL---PILEPGLLPASMVDLSDVLAKPAVIL......SAPALSQFV--------...ISKPHPNmphtvsiipFNPSGTDPAFIstwqaasqnmvyntstapLKP.........ATGSSQTVSVKAVAQGAVITATTVPQAMPARGTggelpVMSASTPARDQVAACFVAENTGDspdnpssfLTSCHPCDPNTVIVAQQFQPPQCVTLLQVTCAPSST.PPPDSTVRAPVVQLPTVVPLPASAFLPALAQPEASGEELP------GGHDGDQGVPCRDSTAAATAAEATTPKRK--QRSKERSSKKRKALTVPEADT--.....-----------.TPSTTTPGTSLGSITTP.QDVHATDVATSEGPSEAQPPLLSLPP.............PLDVDQSLFALLDEAGP-----------------ETWDVGSPLS....PTDDALLSSILQGLYQLDTPPPLRSpspasfgpESPADIPSP..................................
RTA_EBVA8/81-372                ...ILRNNRVRRRAENAGNDACSIACPIVMRYVLDHLIVVTDRFFIQAPSNRVMIPATIGTAMYKLLKHSRVRAYTYSKVLGVDRAAIMASGKQVVEHLNRMEKEGLLSSKFKAFCKWVFTYPVLEEMFQTM--....VSSKTGHLTDDVKDVRALIKTLP....RASYSSHAGQRSyVSGVLPACLLSTKSKAVETPILVSGADRMDEELMGNDGGAshtearYSESGQFHAFTDELESL...-------.........--PSPTMP---..................LKPgaqsadcgdSSSSSSDSGNSDTEQSEREEARAEAPRLRAPK-.....SRRTSRPNRGQT-----------........------------------------------------.----------------------------------------------------------------------------------------------------.....-----------.-----------------.--------------------------.............--------------------------------------------....-------------------------........---------pc................................
BRLF1_SHV21/101-330             ...LLRNYKTKQRSQPVNSTVVSRYAHHVVKYIMQRLVYTTDRLFLTAPTSGIVLPVPLANAIFNLLSHCRKKCTGLWRNYGTEKSVLMGLGKEITLCYQALNESGIVSTTLAAFIKLSFPTISIPNLFKPMFQ....SCKGNQDNFPDIC-TQGSVIRRP....HQGVFGDT----.FP--IPDPLMR---EISENSFKKFSTANISTLLQNPKEIL......-----------------...-------.........-----------..................---.........---------------------------------.....-----------------------........------------------------------------.----------------------------------------------------------------------------------------------------.....-----------.-----------------.--------------------------.............--------------------------------------------....-------------------------........---------emdpfdpriggfplnkeetatplkdssfsnptfi
RTA_EBVB9/369-590               ..q-----------------------------------------------------------------------------------------------------------------------------------....-----------------------....------------.----------------------------------------......-----------------...-------.........-----------..................---.........---------------------------------.....-----------------------........-----------------------------------T.PCPSNAA-------EPEQPWIAAVHQESDERPIFPHPSKPTFLPPVKRK---KGLRDSREGMFLPKPEAGSAISDVFEGREVCQPKRIRPFHPPGSPWAN.....RPLPASLAPTP.TGPVHEPVGSLTPAPVP.QPLDPAPAVTPEASHLLEDPDEETSQavkalremadtviPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLT....PELNEILDTFLND------------........---------ecllha............................
BRLF1_ALHV1/105-619             ...LFRSYKQRVRTHFGKQLLCATASSQIIRFFLERVIRHTDKWFLLAPCNGLILPQELAKEMYVLLSEARGKALNQGRMFSGGRQNMMNAAKKVLTVYSSLRDDGEISPEVKAYMAYIFPVPDIEQVFQPLFKleqeIRKGKATLT--QSLLFAPRKRCP....NKTVFSQYGARQ.-RYVLPEVLLEASEP---QSTLAYGCPDISSLLRDSSSTQentdeeSGPCCS--------KTLspgVPQPQSE.........YDPSPTSPPDSdtes..........cdsqVRPes.....tdSDTHAEDDDVPEAPQAASQTQPTTTQETQS---.....CCSVYNPATTQTGFYYNQQSSDN........FAS---------------------RIDASATSTSYGyPGPVTNHGFSTSVFSHTVPTTATGQQQLHQNMYGGGQQTTTYGSYVGGYSDANGQSVGASTSYYTSKPATSRSSTALQWT---------TLFPPASSS--.....--ASSSQVSDYfSGFPYFPGSS----TVP.QAFEPLAPSTPSLLDE----------.............LLDRDSGLVSQQQAPAPPQNDQGGPPQYVPVAQEQQQSSTDPLS....DEMRRIFEFF---------------........---------dsvnpvtrp.........................
#=GC seq_cons                   ...hhRs.+.+.pst.s.p..su.hs..hh+hhhp+llhhT-+hF..ussstl.hP..lsp.ha.h.pc.+h+shs..+.hsst+tshM..spplh.hhpthpttt.lo.p.tAhhhh.a....l.phht.h........pt..t.......h.t..hphP....p.sh.u...........hPtsLh.........shh..shsphs..L.tst.h............................................................................................................................................................................................s.ssP.ps............s..Ass.....t....st.p.s......tth........................................................................................................................................................................................................................p................................
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