GenomeNet

Database: Pfam
Entry: Herpes_TAF50
LinkDB: Herpes_TAF50
Original site: Herpes_TAF50 
#=GF ID   Herpes_TAF50
#=GF AC   PF03326.10
#=GF DE   Herpesvirus transcription activation factor (transactivator)
#=GF AU   Mifsud W
#=GF SE   Pfam-B_3658 (release 6.5)
#=GF GA   19.70 19.70;
#=GF TC   20.60 20.60;
#=GF NC   19.60 19.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10559285
#=GF RT   The activation domain of herpesvirus saimiri R protein interacts
#=GF RT   with the TATA-binding protein. 
#=GF RA   Hall KT, Stevenson AJ, Goodwin DJ, Gibson PC, Markham AF,
#=GF RA   Whitehouse A; 
#=GF RL   J Virol 1999;73:9756-9763.
#=GF DR   INTERPRO; IPR004998;
#=GF CC   This family includes EBV BRLF1 and similar ORF 50 proteins from
#=GF CC   other herpesviruses.
#=GF SQ   9
#=GS D9QL74_BRESC/1-79    AC D9QL74.1
#=GS RTA_EBVA8/369-590    AC Q1HVG0.1
#=GS RTA_EBVA8/81-377     AC Q1HVG0.1
#=GS RTA_EBVB9/81-372     AC P03209.1
#=GS BRLF1_EHV2/36-591    AC Q66652.1
#=GS ORF50_HHV8P/85-651   AC F5HCV3.1
#=GS RTA_EBVB9/369-590    AC P03209.1
#=GS BRLF1_ALHV1/105-619  AC O36398.1
#=GS BRLF1_SHV21/101-369  AC Q01012.1
D9QL74_BRESC/1-79               mkk-----------------------------------------------------------------------------------------------------------------------------------....-----------------------....------------..---------------------------------------......---------.....---...-------.........-------------------..........---.........---------------------------------.....------------------------------.-----------LIVAGALALTALAAAGCGRMADLET.PGPRETERAPRDARAPDLPDPATVNRPSSQIPIDGGPSNP-FGSPAAARD------------------------------------------------.........---------.-----------------.--------------------------.............--------------------------------------------....-------------------------........---------pr.....................................................................
RTA_EBVA8/369-590               ..q-----------------------------------------------------------------------------------------------------------------------------------....-----------------------....------------..---------------------------------------......---------.....---...-------.........-------------------..........---.........---------------------------------.....------------------------------.-----------------------------------T.PCPSNAE-------EPEQPWIAAVHQESDERPIFPHPSKPTFLPPVKRK---KGLRDSREGMFLPKPEAGSAISDVFEGREVCQPKRIRPFHPPGSPWan.....rpLPASLAPTP.TGPVHEPVGSLTPAPVP.RPLDPAPAVTPEASHLLEDPDEETSQavkalremadtviPQKEEAAICGQMDLNHPPPRGHLDELTTTLESMTEDLNLDSPLT....PELNEILDTFLND------------........---------ecllha.................................................................
RTA_EBVA8/81-377                ...ILRNNRVRRRAENAGNDACSIACPIVMRYVLDHLIVVTDRFFIQAPSNRVMIPATIGTAMYKLLKHSRVRAYTYSKVLGVDRAAIMASGKQVVEHLNRMEKEGLLSSKFKAFCKWVFTYPVLEEMFQTM--....VSSKTGHLTDDVKDVRALIKTLP....RASYSSHAGQRSyvSGVLPACLLSTKSKAVETPILVSGADRMDEELMGNDGGAshtearYSESGQFHAftdelESL...-------.........--PSPTMP-----------..........LKPgaqsadcgdSSSSSSDSGNSDTEQSEREEARAEAPRLRAPK-.....SRRTSRPNRGQT------------------.------------------------------------.--------------------------------------------------------------------------------------------------.........---------.-----------------.--------------------------.............--------------------------------------------....-------------------------........---------pcpsnae................................................................
RTA_EBVB9/81-372                ...ILRNNRVRRRAENAGNDACSIACPIVMRYVLDHLIVVTDRFFIQAPSNRVMIPATIGTAMYKLLKHSRVRAYTYSKVLGVDRAAIMASGKQVVEHLNRMEKEGLLSSKFKAFCKWVFTYPVLEEMFQTM--....VSSKTGHLTDDVKDVRALIKTLP....RASYSSHAGQRSyvSGVLPACLLSTKSKAVETPILVSGADRMDEELMGNDGGAshtearYSESGQFHAftdelESL...-------.........--PSPTMP-----------..........LKPgaqsadcgdSSSSSSDSGNSDTEQSEREEARAEAPRLRAPK-.....SRRTSRPNRGQT------------------.------------------------------------.--------------------------------------------------------------------------------------------------.........---------.-----------------.--------------------------.............--------------------------------------------....-------------------------........---------pc.....................................................................
BRLF1_EHV2/36-591               ...LFRNYKNKQSAESANTNPCALMAQQFLKFHTERLLVCTDRFFSTGCCSQINMPYDLCQHVFKFQQDLRKRCIASWKTLSGGRRAFMTVVQDIFTCFTTLRANELITPRQQAFFKLSYPPCRVQNVINILNVvhtqGIKDLKSLN-----MQKIKKRTP....HAGIFSASGQPL.fP--IPEALLVDFNG---EGIIRSDIADVSPFLQNPEEFL......---ATDFFTyikrfQGVgvqIRDPEPR.........YQPASQQPQQA--------..........LRP.........-------------QQQVLQQATAYPASVQAGGF.....AIQTESPMEGTSAQYFLAAQQHG-------.VVGLFPSTATLVPIAGSTGVTEVVSYGHNSTSPVSTfSAPSTSVTEADHQTQPRRSRKATAKRKHQQVQDGNEDEGPQRHPQAHSRQFFQG-----AASHQTAQPAQVLQQSVIHGTQGALYFMGPAQQIPGDHSqipvisnamLQSVLQQQGgSGAAIYDLSQLQPCVVPvQQQAAQEVAVPTAVIHYQPAMQPQPQ.............PYQQQQFLQPQQQAQTPSPQMQQRQLTPQSSPEPADEEEEGPLNlttrTEDHEILEEILSNLYPEERRQQEQQ........HQQGEEAAP.......................................................................
ORF50_HHV8P/85-651              ...FFRASRMRTKGAAGYNVPCAEASQGIIRILTERILFCTEKAFLTAACSGVSLPPAICKLLHEIYTEMKAKCLGAWRRLVCNRRPIMILTSSLLKLYNTYDTAGLLSEQSRALCLLVFQPVYLPRIMAPLEI....MTKGQLAPENFYSITGSAEKRRPittgKVTGLSYPG---..SGLMPESLIL---PILEPGLLPASMVDLSDVLAKPAVIL......SAPALSQFV.....---...ISKPHPNmphtvsiipFNPSGTDPAFISTWQAASQnmvyntstapLKP.........ATGSSQTVSVKAVAQGAVITATTVPQAMPARGTggelpVMSASTPARDQVAACFVAENTGDSPDNPSSfLTSCHPCDPNTVIVAQQFQPPQCVTLLQVTCAPSST.PPPDSTVRAPVVQLPTVVPLPASAFLPALAQPEASGEELP------GGHDGDQGVPCRDSTAAATAAEATTPKRK--QRSKERSSKKRKALTVPEADT.........---------.TPSTTTPGTSLGSITTP.QDVHATDVATSEGPSEAQPPLLSLPP.............PLDVDQSLFALLDEAGP-----------------ETWDVGSPLS....PTDDALLSSILQGLYQLDTPPPLRSpspasfgpESPADIPSP.......................................................................
RTA_EBVB9/369-590               ..q-----------------------------------------------------------------------------------------------------------------------------------....-----------------------....------------..---------------------------------------......---------.....---...-------.........-------------------..........---.........---------------------------------.....------------------------------.-----------------------------------T.PCPSNAA-------EPEQPWIAAVHQESDERPIFPHPSKPTFLPPVKRK---KGLRDSREGMFLPKPEAGSAISDVFEGREVCQPKRIRPFHPPGSPWan.....rpLPASLAPTP.TGPVHEPVGSLTPAPVP.QPLDPAPAVTPEASHLLEDPDEETSQavkalremadtviPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLT....PELNEILDTFLND------------........---------ecllha.................................................................
BRLF1_ALHV1/105-619             ...LFRSYKQRVRTHFGKQLLCATASSQIIRFFLERVIRHTDKWFLLAPCNGLILPQELAKEMYVLLSEARGKALNQGRMFSGGRQNMMNAAKKVLTVYSSLRDDGEISPEVKAYMAYIFPVPDIEQVFQPLFKleqeIRKGKATLT--QSLLFAPRKRCP....NKTVFSQYGARQ..RYVLPEVLLEASEP---QSTLAYGCPDISSLLRDSSSTQentdeeSGPCCS---.....KTLspgVPQPQSE.........YDPSPTSPPDSDTESCDSQ..........VRPes.....tdSDTHAEDDDVPEAPQAASQTQPTTTQETQS---.....CCSVYNPATTQTGFYYNQQSSDNFASRIDA.----------------------------SATSTSYGyPGPVTNHGFSTSVFSHTVPTTATGQQQLHQNMYGGGQQTTTYGSYVGGYSDANGQSVGASTSYYTSKPATSRSSTALQWT---------TLFPPASSS.........ASSSQVSDYfSGFPYFPGSS----TVP.QAFEPLAPSTPSLLDE----------.............LLDRDSGLVSQQQAPAPPQNDQGGPPQYVPVAQEQQQSSTDPLS....DEMRRIFEFF---------------........---------dsvnpvtrp..............................................................
BRLF1_SHV21/101-369             ...LLRNYKTKQRSQPVNSTVVSRYAHHVVKYIMQRLVYTTDRLFLTAPTSGIVLPVPLANAIFNLLSHCRKKCTGLWRNYGTEKSVLMGLGKEITLCYQALNESGIVSTTLAAFIKLSFPTISIPNLFKPMFQ....SCKGNQDNFPDIC-TQGSVIRRP....HQGVFGDTF---..P--IPDPLMR---EISENSFKKFSTANISTLLQNPKEIL......EM-------.....---...-------.........-------------------..........---.........---------------------------------.....------------------------------.------------------------------------.--------------------------------------------------------------------------------------------------.........---------.-----------------.--------------------------.............--------------------------------------------....-------------------------........---------dpfdpriggfplnkeetatplkdssfsnptfintgaantllpaasvtpaleslfspthfpcmsdesiasts
#=GC seq_cons                   ...hhRs.+.+.pst.s.p..su.hs..hh+hhhp+llhhT-+hF..ussstl.hP..lsp.ha.h.pc.+h+shs..+.hsst+tshM..spplh.hhpthpttt.lo.p.tAhhhh.a....l.phht.h........pt..t.......h.t..hphP....p.sh.u..h........hPtsLh.........shh..shsphs..L.tst.h............................................................................................................................................................................................s.ssP.ps............s..Ass.....t....st.p.s......tth........................................................................................................................................................................................................................s.....................................................................
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