GenomeNet

Database: Pfam
Entry: Herpes_TK
LinkDB: Herpes_TK
Original site: Herpes_TK 
#=GF ID   Herpes_TK
#=GF AC   PF00693.16
#=GF DE   Thymidine kinase from herpesvirus
#=GF PI   TK_herpes; 
#=GF AU   Bateman A
#=GF SE   Pfam-B_186 (release 2.1)
#=GF GA   25.00 25.00;
#=GF TC   53.40 52.90;
#=GF NC   23.50 18.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Thymidine_kinase_from_herpesvirus
#=GF RN   [1]
#=GF RM   7552712
#=GF RT   Crystal structures of the thymidine kinase from herpes simplex
#=GF RT   virus type-1 in complex with deoxythymidine and ganciclovir. 
#=GF RA   Brown DG, Visse R, Sandhu G, Davies A, Rizkallah PJ, Melitz C,
#=GF RA   Summers WC, Sanderson MR; 
#=GF RL   Nat Struct Biol 1995;2:876-881.
#=GF DR   INTERPRO; IPR001889;
#=GF DR   SCOP; 1kin; fa;
#=GF SQ   11
#=GS KITH_HHV2H/56-330   AC P89446.1
#=GS KITH_EBVA8/291-551  AC Q1HVD1.1
#=GS KITH_ALHV1/245-478  AC O36371.1
#=GS KITH_HHV11/56-329   AC P03176.4
#=GS KITH_HHV11/56-329   DR PDB; 1E2J B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1KI3 A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 3RDP B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 4OQX A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1P7C A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 3F0T A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1E2N A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1KI6 B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1KIM A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1OF1 A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1E2N B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1E2P A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1E2J A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1KI2 B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 4OQM A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 4JBY B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 3F0T B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 4IVP A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1E2K A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1E2I A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 4OQX B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 4OQN A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 4JBX A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 4OQL A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 4JBY A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1KI8 A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1KI8 B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 4IVQ A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 4IVP B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1VTK A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 4IVR B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1E2K B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 2KI5 B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1KI4 A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1E2L A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1KIM B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1KI4 B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 3VTK A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1KI6 A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 4OQM B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1E2M A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 4OQL B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1E2P B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1E2M B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1E2H A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1OF1 B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1E2I B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 4IVR A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1KI7 A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1QHI B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1P7C B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1QHI A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 3RDP A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 4IVQ B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1E2L B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 4OQN B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 2VTK A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1E2H B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 2KI5 A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1KI7 B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1KI3 B; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 1KI2 A; 56-329;
#=GS KITH_HHV11/56-329   DR PDB; 4JBX B; 56-329;
#=GS KITH_GAHVM/26-307   AC Q9E6P5.1
#=GS KITH_HHV8P/260-491  AC F5HB62.1
#=GS KITH_VZVD/19-298    AC P09250.1
#=GS KITH_PSHV1/11-294   AC Q6UDK9.1
#=GS KITH_EBVB9/291-551  AC P03177.2
#=GS KITH_EHV2/301-528   AC Q66624.2
#=GS KITH_SHV21/216-472  AC P21293.1
KITH_HHV2H/56-330              GPHGVGKTTTSAQLMEALGPR.DNIVYVPEPMTYWQVLGAS..ETLTNIYNTQHRLDRGEISAGEAAVVMTSAQITMSTPYAATDAVLAPHIGGEA--VGPQAPPPALTLVFDRHPIASLLCYPAARYLMGSMTPQAVLAFVALMPPTAPGTNLVLGVL.PEAEHADRLARRQRPGE.R.LDLAMLSAIRRVYDLLANTVRYLQ.....RGGRWREDWGRL---TGVAAATPRPDPEDGAG.SLPRIEDTLFALFRVPELLAPNGDLYHIFAWVLDVLADRLLPMHLFVLDY............................................................................
#=GR KITH_HHV2H/56-330   AS    .............................*..................................................................................................................................................................................................................................................................................................................................................
KITH_EBVA8/291-551             GAPGVGKTTMLNHLKAV--FG.DLTIVVPEPMRYWTHVYE-..NAIKAMHKNVTRARHGR---EDTSAEVLACQMKFTTPFRVLASRKRSLLVTES--GARSVAPLDCWILHDRHLLSASVVFPLMLLRSQLLSYSDFIQVLATFTA-DPGDTIVWMKL.NVEENMRRLKKRGRKHE.SgLDAGYLKSVNDAYHAVYCA-----.....--------------------------------.--------------------------------------------------wlltqyfapedivkvcaglttittvchqshtpiirsgvaeklyknsifsvlkeviqpfradavllevclaftrtla
#=GR KITH_EBVA8/291-551  AS    .............................*..................................................................................................................................................................................................................................................................................................................................................
KITH_ALHV1/245-478             GCMAAGKTTLL-NFARQTLSD.DEALTIPEPMRFWTEVYT-..NVLSQIVKINKECKPGKTSTT-AE--LVSCQLKFATPLKTQSLFLQRSVKKDS--EMQPVGPLDKWVIVDRHQLSALVVFPLVLMRRGMLSFSDFFNLLG-MFEAHPGEVIALMSV.NVEENFTRLKKRGRVCErH.IDRDYIKEIKGSFNAAYCAWLFLQy...fS-------------------------------.--------------------------------------------------iqttmqicmglssldeacategvchttasriwnnsmlvtl....................................
#=GR KITH_ALHV1/245-478  AS    .............................*..................................................................................................................................................................................................................................................................................................................................................
KITH_HHV11/56-329              GPHGMGKTTTT-QLLVALGSR.DDIVYVPEPMTYWRVLGAS..ETIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGGEA--GSSHAPPPALTLIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIPPTLPGTNIVLGAL.PEDRHIDRLAKRQRPGE.R.LDLAMLAAIRRVYGLLANTVRYLQ.....CGGSWREDWGQL---SGTAVPPQGAEPQSNAG.PRPHIGDTLFTLFRAPELLAPNGDLYNVFAWALDVLAKRLRSMHVFILDY............................................................................
#=GR KITH_HHV11/56-329   SS    SSTTSSHHHHH-HHHHHHSTT.TTEEEE---HHHHHTTSSS..SHHHHHHHHHHHHHTTSS-HHHHHHHHHHHHHHHHHHHHHHHHHHGGGEEEEE--ESTTS-S-SEEEEEES-HHHHHTHHHHHHHHTTSS-HHHHHHHHHTS----TTEEEEEEE-.-HHHHHHHHHHS-TTT-.-.--HHHHHHHHHHHHHHHHHHHHHH.....TT--HHHHGGGG---TS-----------SSSS.S---GGGSGGGGGG-GGGB-TTSSB-HHHHHHHHHHHHHHHTCEEEEEET............................................................................
#=GR KITH_HHV11/56-329   AS    .............................*..................................................................................................................................................................................................................................................................................................................................................
KITH_GAHVM/26-307              GSMGIGKTSMLNEIPTHSLMG.VPVLKVFEPMKYWRYYFT-..DLVTTVNDTCDRRRRGEFSLFQSSMIVTALQSKFADPYLVFHERLS----SKCHRITGTRGNPSLILILDRHPISATVCFPIARHLTGDCSLEMLISMIIRLPQEPPGCNLVIVDLhDEKEHVSRLSSRNRTGE.K.TDLLMLRALNAVYSCLVDTIMYANhicpySKDEWESEWLDLPWFDTSLATTFINEPRTDYRgSRVSLHHTLLAIFKRRELCAEDGSLSTTHAWILWGLLMKLRNINVERFNI............................................................................
#=GR KITH_GAHVM/26-307   AS    .............................*..................................................................................................................................................................................................................................................................................................................................................
KITH_HHV8P/260-491             GVMGVGKSTLVNAV-CGILPQ.ERVTSFPEPMVYWTRAFT-..DCYKEISHLMKSGKAGD---PLTSAKIYSCQNKFSLPFRTNATAILRMMQPWN--VGGGSGRGTHWCVFDRHLLSPAVVFPLMHLKHGRLSFDHFFQLLSIF-RATEGDVVAILTL.SSAESLRRVRARGRKNDgT.VEQNYIRELAWAYHAVYCSWIMLQ.....--------------------------------.--------------------------------------------------yitveqmvqlcvqttnipeicfrsvrlahkeetlknlheqs...................................
#=GR KITH_HHV8P/260-491  AS    .............................*..................................................................................................................................................................................................................................................................................................................................................
KITH_VZVD/19-298               GAYGIGKTTAAEEFLHHFAITpNRILLIGEPLSYWRNLAGE..DAICGIYGTQTRRLNGDVSPEDAQRLTAHFQSLFCSPHAIMHAKISALMDTSTSDLVQVNKEPYKIMLSDRHPIASTICFPLSRYLVGDMSPAALPGLLFTLPAEPPGTNLVVCTV.SLPSHLSRVSKRARPGE.T.VNLPFVMVLRNVYIMLINTIIFLK.....-TNNWHAGWNTLSFCNDVFKQKLQKSECIKLR.EVPGIEDTLFAVLKLPELCGEFGNILPLWAWGMETLSNCSRSMSPFVLS-l...........................................................................
#=GR KITH_VZVD/19-298    AS    .............................*..................................................................................................................................................................................................................................................................................................................................................
KITH_PSHV1/11-294              GAFGIGKTTVLRQIQKSAAYR.FRRIYLEEPMRAWRSWFVDdhDAIREIYTTQELKDAGEIDLREASRRVCYAQVSLSAPFHIMNAVIYGIISGESEATSAHLGEGDYFVGVDRHPLASCLCFPVARFVTGYLEYTDLIALVATLPDYPRGASIAILDL.SVEEQARRITERSRSGE.H.VNKTFLRILRNVFIIMYNTVAYLRn...vSIDKACADREALEDFRGSQLESDMHKIDIQPR.DDPNASETLFAVMASDATWRKNRKQSALFVYTMAKLDALLRSLNMHIVDI............................................................................
#=GR KITH_PSHV1/11-294   AS    .............................*..................................................................................................................................................................................................................................................................................................................................................
KITH_EBVB9/291-551             GAPGVGKTTMLNHLKAV--FG.DLTIVVPEPMRYWTHVYE-..NAIKAMHKNVTRARHGR---EDTSAEVLACQMKFTTPFRVLASRKRSLLVTES--GARSVAPLDCWILHDRHLLSASVVFPLMLLRSQLLSYSDFIQVLATFTA-DPGDTIVWMKL.NVEENMRRLKKRGRKHE.SgLDAGYLKSVNDAYHAVYCA-----.....--------------------------------.--------------------------------------------------wlltqyfapedivkvcaglttittvchqshtpiirsgvaeklyknsifsvlkeviqpfradavllevclaftrtla
#=GR KITH_EBVB9/291-551  AS    .............................*..................................................................................................................................................................................................................................................................................................................................................
KITH_EHV2/301-528              GSMGVGKTTLIRHMREI--NG.DNVISFVEPMFYWREVYS-..DCVKLIYSACKPFNLGKMST---SNKVLSAQMKFMTPMKCLQTSVRRYVKANE--PLQEKTAMDNWLLFDRHPLSATLVFPYLSLKNGYLAFEHFLALAANFTA-HEGDIIALLCM.GEEDNLKMVKLRNRKGE.SgVTSAHLKDLGQAFHACYCT-----.....--------------------------------.--------------------------------------------------wlllkylspedmvsvcccdvtlndicimrsmssskvtmakslf.................................
#=GR KITH_EHV2/301-528   AS    .............................*..................................................................................................................................................................................................................................................................................................................................................
KITH_SHV21/216-472             GSIGVGKTTLLKSM-NGILGG.KNVLAFHEPIAYWTDVFS-..NSLEEVYKLTLPAKVGRTSN---SAKLLACQLKFASPLLALKTATDRLSSPK-----NSLLSSDMWVMFDRHPLSATVVFPYMHFQNGFLSFSHLIQLWSSF-KASRGDNIILLNL.NSQENLKRVKKRNRKEE.KsVSIEHIRLLNNCYHAVYC------.....--------------------------------.--------------------------------------------------awllvqnftpeeivevcfnakhitdlssskpsflakhvstedmlkssifntwiemtkahrdsctlmeclltfcke.
#=GR KITH_SHV21/216-472  AS    .............................*..................................................................................................................................................................................................................................................................................................................................................
#=GC SS_cons                   SSTTSSHHHHH-HHHHHHSTT.TTEEEE---HHHHHTTSSS..SHHHHHHHHHHHHHTTSS-HHHHHHHHHHHHHHHHHHHHHHHHHHGGGEEEEE--ESTTS-S-SEEEEEES-HHHHHTHHHHHHHHTTSS-HHHHHHHHHTS----TTEEEEEEE-.-HHHHHHHHHHS-TTT-.-.--HHHHHHHHHHHHHHHHHHHHHH.....TT--HHHHGGGG---TS-----------SSSS.S---GGGSGGGGGG-GGGB-TTSSB-HHHHHHHHHHHHHHHTCEEEEEET............................................................................
#=GC seq_cons                  GuhGlGKTThlpplhpshh.s.-pllhlsEPMpYWpplas...-slppIapspcctctGchS.tpsSshlhusQhKFuoPatshsstlpthlsscs..sspsssssshallaDRHPLSAslsFPlh+hhsGhLSaschlslluphsstsPGssIllhsL.s.cEphcRlp+RsRpsE.p.l-hsaL+slpssYpslYsohhhhp........................................................................................h...........................................................................
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