GenomeNet

Database: Pfam
Entry: Herpes_UL24
LinkDB: Herpes_UL24
Original site: Herpes_UL24 
#=GF ID   Herpes_UL24
#=GF AC   PF01646.13
#=GF DE   Herpes virus proteins UL24 and UL76
#=GF AU   Bashton M, Bateman A
#=GF SE   Pfam-B_946 (release 4.1)
#=GF GA   18.90 18.90;
#=GF TC   19.10 141.50;
#=GF NC   16.40 18.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   9501052
#=GF RT   Importance of the herpes simplex virus UL24 gene for productive
#=GF RT   ganglionic infection in mice. 
#=GF RA   Jacobson JG, Chen SH, Cook WJ, Kramer MF, Coen DM; 
#=GF RL   Virology 1998;242:161-169.
#=GF RN   [2]
#=GF RM   23966401
#=GF RT   Human cytomegalovirus UL76 elicits novel aggresome formation via
#=GF RT   interaction with S5a of the ubiquitin proteasome system.
#=GF RA   Lin SR, Jiang MJ, Wang HH, Hu CH, Hsu MS, Hsi E, Duh CY, Wang
#=GF RA   SK;
#=GF RL   J Virol. 2013;87:11562-11578.
#=GF DR   INTERPRO; IPR002580;
#=GF CC   This family consists of various herpes virus proteins; the gene
#=GF CC   20 product, U49 protein, UL24 and UL76 proteins and BXRF1. The
#=GF CC   UL24 gene (product of the 24th ORF) is not essential for virus
#=GF CC   replication, and mutants with lesions in UL24 show a reduced
#=GF CC   ability to replicate in tissue culture and have reduced
#=GF CC   thymidine kinase activity, as the UL24 gene overlaps with
#=GF CC   thymidine kinase [1]. The family of proteins is involved in
#=GF CC   viral production, latency, and reactivation. Protein UL76
#=GF CC   presents as globular aggresomes in the nuclei of transiently
#=GF CC   transfected cells. Bioinformatic analyses predict that UL76 has
#=GF CC   a propensity for aggregation and targets cellular proteins
#=GF CC   implicated in protein folding and ubiquitin-proteasome systems.
#=GF CC   UL76 interacts with the VWA domain of S5a, the 26S proteasome
#=GF CC   non-ATPase regulatory subunit 4 (or PSMD4, or Rpn10), forming a
#=GF CC   complex in the late phase of infection [2].
#=GF SQ   14
#=GS UL24_HHV8P/14-187    AC Q2HRB2.1
#=GS UL24_GAHVM/44-234    AC Q9E6P4.1
#=GS UL24_EBVB9/19-192    AC P03232.1
#=GS UL24_SHV21/14-187    AC Q01005.1
#=GS UL24_EHV2/13-186     AC Q66623.1
#=GS UL76_HCMVM/17-200    AC Q6SW66.1
#=GS UL24_HHV6U/4-185     AC Q06092.1
#=GS UL24_VZVD/4-190      AC P09288.1
#=GS UL24_ALHV1/14-186    AC O36370.1
#=GS UL24_HHV2H/19-203    AC P89447.1
#=GS UL24_PSHV1/61-246    AC Q6UDK8.1
#=GS Q1HVD0_EBVA8/19-192  AC Q1HVD0.1
#=GS UL24_HHV11/8-192     AC P10208.1
#=GS UL24_HHV6Z/4-185     AC P52545.1
UL24_HHV8P/14-187               ..s-RLPAARKRAGNRAHLATYRRLLK-Y............STL.............PDLWRFL...SSRPQNP..PLGHHRLFFEVTLGHRIADCVILVSGGHQP..----...VCYVVELKTCLSHQLIPT...NTVRTSQRAQGLCQLSDSIHYIAHSAP..PGTEAWTITPLLIFKNQKTLKTVYSEspGAFPTPVHTTEGKLCAFLTARENADIRK-v........
UL24_GAHVM/44-234               ..n-VLRKRRLAAGVRCHDRFYKRLYAEAmclgsqvydwpgRSF.............AKIFG--...KVMVLDVfkQLTDFRLVFEVNLERRRPDCICMFKLPRDL..WEVGcdgVCVILELKTCKFSRNLKT...-RSKHEQRLTGIKQLLDSKSLIGQIAP..QGSDCIVICPMLVFVARRKLSVLHVM..CLKKRHIVTDFHRLCSILATASDYKARI-t........
UL24_EBVB9/19-192               ..h-SLPPARKAAGKRAHLRCYSKLLS-L............KSW.............EQLASFL...SL-PPGP..TFTDFRLFFEVTLGRRIADCVVV-ALQPYP..----...RCYIVEFKTAMSNTANPQ...SVTRKAQRLEGTAQLCDCANFLRTSCPpvLGSQGLEVLAALVFKNQRSLRTLQVEfpALGQKTLPTSTTGLLNLLSRWQDGALRA-r........
UL24_SHV21/14-187               ..a-HLPNKRKIAGNKAHLETYKKLAK-Y............TVS.............ASIFKFL...SISHPCP..LRAKTRLFFEVSLGNRIADCVMLTSCGETR..----...ICYVIELKTCMTSNLDLI...SDIRKSQRSQGLCQLADTVNFIHNYAP..LGRQAWTVLPILIFKSQKTLKTLHIEtpKFPVNLTHTSEEKLSCFLWSRADVEIRK-k........
UL24_EHV2/13-186                ..s-RLPTKRKLAGQKAHLEMYRKLAK-Y............SSV.............GHLLKFL...AIDHPCP..TKCQLKIFFEVCLGNRIADCVILLSCGETR..----...LCYIIELKTCMSDSPSMY...NETRLCQRSQGLCQLSDALRFISFNAP..AGRQKWHLVPHLIFKSQRGLKTIYTEtpQFPTNIIHSSPDKLASFFFSRADREVSE-k........
UL76_HCMVM/17-200               ..r-RLPHVRKRIGKRKHLDIYRRLLRVF............PSF.............VALNRLL..gGLFPPEL..QKYRRRLFIEVRLSRRIPDCVLVFLPPDSG..SRGI..vYCYVIEFKTTYSDADDQSvrwHATHSLQYAEGLRQLKGALVDFDFLRLprGGGQVWSVVPSLVFFQQKADRPSFYR..AFRSGRFDLCTDSVLDYLGRRQDESVAH-l........
UL24_HHV6U/4-185                ..t-GLPDIRKKIGQFHHLRIYKQILSLQ............GNF.............ARLNYFL..gDVFPANL..RSASVSVFFEVRLGPRIPDCIVLLKSVDAK..DEFA..fHCYFFEFKTTLGKSTMQSvhhNCIHQAQYLQGLRQLQQSISFLDQYLI..ADEVSWNVVPVICFFRQWGLKLDFFK..KFSGKTKRLSFSFIRDLFARSQDGAVQS-l........
UL24_VZVD/4-190                 ..s-RIRAKCFRLGQRCHTRFYDVLKKDI............DNVrrgf....adafnPRLAKLL..sPLSHVDV.qRAVRISMSFEVNLGRRRPDCVCIIQTESSG..AGKT...VCFIVELKSCRFSANIHT...-PTKYHQFCEGMRQLRDTMALIKETTP..TGSDEIMVTPLLVFVSQRGLNLLQVT..RLPPKVIHGNLVMLASHLENVAEYTPPI-r........
UL24_ALHV1/14-186               ..n-SLPAKRKKAGLQAHRKVYKQLLQ-Y............HSF.............TKINKFL...ELKHPDP..KKVKYRLFFEVSLGPRIVDVIVLTSYETER..----...VCYVVELKTCLGSEFNFT...-SVRAAQRTQGLCQLYDSTKYLSNNAP..LGGERWEVRAHLLFKSQSAMKTLYVEhpGFQFNQLQCTTGALSVFLKSREDVACRQ-l........
UL24_HHV2H/19-203               lte---RRRVLLAGVRSHTRFYKAFAREV............REFnat......ricgTLLTLMS..gSLQGRSL.fEATRVTLICEVDLGPRRPDCICVFEFANDK..TLGG...VCVILELKTCKSISSGDT...-ASKREQRTTGMKQLRHSLKLLQSLAP..PGDKVVYLCPILVFVAQRTLRVSRVT..RLVPQKISGNITAAVRMLQSLSTYAVP--pe.......
UL24_PSHV1/61-246               .rt--LVAARLLAGVRCHNRFYGALVSSF............ETAycmnhrhgsdglaA----TIiaeACGAVPV..CSLNTTIMFEVNLGGRRPDCICVLDRAGVAgaPRES...VCLIVELKTCRFSRSALT...-ESKKNQYATGLRQLRDSAKIICDVAV..PGADFVHIVPVLVFVAQRSMRIMDVR..KFNERVVRANAELLRL-------------rlaalgvys
Q1HVD0_EBVA8/19-192             ..h-SLPPARKAAGKRAHLRCYSKLLS-L............KSW.............EQLASFL...SL-PPGP..TFTDFRLFFEVTLGRRIADCVV-VALQPSP..----...RCYIVEFKTAMSNTANPQ...SVTRKAQRLEGTAQLCDCANFLRTSCPpvLGSQGLEVLAALVFKNQRSLRTLQVEfpALGQKTLPTSTTGLLNLLSRWQDGALRA-r........
UL24_HHV11/8-192                lve---RRRVLMAGVRSHTRFYKALAEEV............REFhat......kicgTLLTLLS..gSLQGRSV.fEATRVTLICEVDLGPRRPDCICVFEFANDK..TLGG...VCVIIELKTCKYISSGDT...-ASKREQRATGMKQLRHSLKLLQSLAP..PGDKIVYLCPVLVFVAQRTLRVSRVT..RLVPQKVSGNITAVVRMLQSLSTYTVPI-e........
UL24_HHV6Z/4-185                ..t-GLPDIRKKIGQFHHLRIYKQILSLQ............GNF.............ARLNYFL..gDVFPANL..RSASVSVFFEVRLGPRIPDCIVLLKSVDAK..DEFA..fHCYFFEFKTTLGKSTMQSvhhNCIHQAQYLQGLRQLHQSISFLDQYLI..ADEVLWNVVPVICFFRQWGLKLDFFK..KFSGKTKRLSFSFICDLFARSQDGAVQS-l........
#=GC seq_cons                   ..s.tLPstRKtAGpRsHhRhY+pLhp.h............psa.............spLsthL...ul.ssss..ptschpLFFEVsLGtRIsDClslhphssst.........lCYllELKTChussss.o....so+psQRspGlpQLpDohphlpphsP..sGspthplsPhLlFhsQ+uL+shhlc..phsspplpsshstLsshLtphpDhslpt.h........
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