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Database: Pfam
Entry: Herpes_gE
LinkDB: Herpes_gE
Original site: Herpes_gE 
#=GF ID   Herpes_gE
#=GF AC   PF02480.14
#=GF DE   Alphaherpesvirus glycoprotein E
#=GF AU   Mian N, Bateman A
#=GF SE   Pfam-B_849 (release 5.4)
#=GF GA   21.20 21.20;
#=GF TC   21.20 21.20;
#=GF NC   21.10 21.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10881679
#=GF RT   Epitopes on glycoprotein E and on the glycoprotein
#=GF RT   E/glycoprotein I complex of bovine herpesvirus 1 are expressed
#=GF RT   by all of 222 isolates and 11 vaccine strains. 
#=GF RA   Rijsewijk FA, Kaashoek MJ, Langeveld JP, Maris-Veldhuis MA,
#=GF RA   Magdalena J, Verschuren SB, Meloen RH, van Oirschot JT; 
#=GF RL   Arch Virol 2000;145:921-936.
#=GF DR   INTERPRO; IPR003404;
#=GF CC   Glycoprotein E (gE) of Alphaherpesvirus forms a complex with 
#=GF CC   glycoprotein I (gI) (Pfam:PF01688), functioning as an
#=GF CC   immunoglobulin G (IgG) Fc binding protein. gE is involved in
#=GF CC   virus spread but is not essential for propagation [1].
#=GF SQ   26
#=GS G7KDB0_MEDTR/247-330      AC G7KDB0.2
#=GS N1RMN9_FUSC4/1-90         AC N1RMN9.1
#=GS GE_HHV11/59-506           AC P04488.1
#=GS GE_HHV11/59-506           DR PDB; 2GJ7 F; 220-390;
#=GS GE_HHV11/59-506           DR PDB; 2GJ7 E; 220-390;
#=GS GE_HHV11/59-506           DR PDB; 2GIY B; 219-390;
#=GS A0A0G2LAI5_DANRE/7-132    AC A0A0G2LAI5.1
#=GS A0A074S7C9_9HOMO/94-258   AC A0A074S7C9.1
#=GS M5BZ29_THACB/25-186       AC M5BZ29.1
#=GS A0A0D9Z4K8_9ORYZ/4-93     AC A0A0D9Z4K8.1
#=GS A0A0K6FLA4_9HOMO/141-247  AC A0A0K6FLA4.1
#=GS A0A0K6FND4_9HOMO/239-331  AC A0A0K6FND4.1
#=GS GE_VZVD/190-616           AC P09259.1
#=GS S7RXH1_GLOTA/131-264      AC S7RXH1.1
#=GS N4TXY7_FUSC1/1-90         AC N4TXY7.1
#=GS L8WV56_THACA/77-175       AC L8WV56.1
#=GS GE_HHV2H/57-501           AC P89475.1
#=GS A0A067NXM1_PLEOS/175-307  AC A0A067NXM1.1
#=GS E7F3K4_DANRE/281-411      AC E7F3K4.2
#=GS X0CHY7_FUSOX/1-90         AC X0CHY7.1
#=GS A0A0M3D2F2_9MICO/131-215  AC A0A0M3D2F2.1
#=GS GE_PSHV1/44-516           AC Q6UDF4.1
#=GS A0A067N107_9HOMO/121-258  AC A0A067N107.1
#=GS A0A0D2XMZ9_FUSO4/1-90     AC A0A0D2XMZ9.1
#=GS W9CQV2_9HELO/158-246      AC W9CQV2.1
#=GS W4ZDP8_STRPU/215-337      AC W4ZDP8.1
#=GS GE_GAHVM/41-479           AC Q77MP7.1
#=GS A0A0K6FQJ8_9HOMO/100-256  AC A0A0K6FQJ8.1
#=GS S7UX88_TOXGO/32-168       AC S7UX88.1
G7KDB0_MEDTR/247-330                 ...........................................................rfy-----------..---------....---------------------...-------------.......----------------------------------.....-------------------------------------------......................................------....----------------.....--------------------------.-----------------------------------------.--------------------------.-----.---------------...-------------------------------------.---.---.---....--..-----ER................NAQPP.PPTSPSTNH.TSSQGKDHTSR--TAIIIAIPI..VIIVLVVCFICIYLRLRVKKPR-.....---KTNQKYGNISVPSE--..-----------------------..----------ndeirnfes....................................
N1RMN9_FUSC4/1-90                    ........................................................matndn-----------..---------....---------------------...-------------.......----------------------------------.....-------------------------------------------......................................------....----------------.....--------------------------.-----------------------------------------.--------------------------.-----.---------------...-------------------------------------.---.---.---....--..-------................-----.--------N.DNNTGFSFGAQPFAWVLIPLFV..ILVLGLTATIVQVRRRRRRRRNQ.....WPGQNTGAPVYTGLRGGR-..-----------------------..----------rtgnrrspwngtrseeglne.........................
GE_HHV11/59-506                      ..............................................................PLDGCGPLHPS..WVSLMPPKQ....--------------VPETVVD...AAC----MRAPVP.......LAMAYAPPAPSATGGLRT----DFVWQERAAVVN.....RSLVIHGVRETDSGLYTLSVGDIKDPARQVASVVLVVQPAPVPtppptpadydeddndeg....edeslagtpasgtprlpPPPAPPrswpSAPEVSHVRGVTVRME.....TPEAILFSPGETFSTNVSIHAIAHDD.QTYSMDVVWLRFDVPTSCAEMRIYESCLYHPQLPECLSPAD.APCAAST--WTSRLAVRSYAGCSRTN.PPPRC.SAEAHMEPVPGLAWQ...AASVNLEFRDASPQHSGLYLCVVYVNDHIHAWGHITI.STA.AQY.RNA....VV..EQPLPQR................GADLA.EPTHPHVGA.PPHAPPTHGALRLGAVMGAALL..LSALGLSVWACMTCWRRRAWRAV.....KSRASGKGPTYIRVADSEL..YADWSSDSEGERDQVPWLAPPERpdSPSTNGSGFE.............................................
#=GR GE_HHV11/59-506           SS    ..............................................................XXXXXXXXXXX..XXXXXXXXX....--------------XXXXXXX...XXX----XXXXXX.......XXXXXXXXXXXXXXXXXX----XXXXXXXXXXXX.....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--SEEEEEE.....--SEEE--TT--EE---EEEEEESSS.--EEEEEEEEEE---TT-SEEEEEHHHHH-TTSHHHHS-TT.GGGEE-----SS-SEEEEEEEEBSSS.-TTTT.EEEEEE---TTEEE-...SS-SSEEESS--GGG-EEEEEEEEETTEEEEEEEEEE.E-T.TT-.-EE....EE..E---XXX................XXXXX.XXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXX.....XXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.............................................
A0A0G2LAI5_DANRE/7-132               ..........................................vlktsteiqtddhikwrfnn-----------..---------....---------------------...-------------.......---NKSPIAENKTGQNFT--GPEEIFKDRLELDKm...tGFLSIKNISQEHAGIYQLKITNSSSAAYVKTFIVIVKKEK-VR......................................------....----------------.....--------------------------.-----------------------------------------.--------------------------.-----.---------------...-------------------------------------.---.---.---....--..-------................-----.---------.----------------------..-----------------------.....-------------------..-----------------------..----------vvegktavlqtpaeiqnydhiewrfnnnespia............
A0A074S7C9_9HOMO/94-258              ...........qtvqaatacicttvmynlvsgcaacqhqlsnkvtrnwvnwntwsalcqnrd-----------..---------....---------------------...-------------.......----------------------------------.....-------------------------------------------......................................------....----------------.....--------------------------.-----------------------------------------.--------------------------.-----.---------------...------------SIQDGIWNRVTGYNDTIPAWAYTKV.FQS.DLFdLQQ....AI..NIGLSST................AGPTS.TATSTATPT.PEAQTSNNVPIIVGAVLGGVGL..ILL-SITIFFCVLRRRQRKWEE-.....-------------------..-----------------------..----------segvnrpdstfvi................................
M5BZ29_THACB/25-186                  .....aatpcicttvmynlvagcaacqhqvsskvtrnwvnwktwsalcpnqasiqdgvwnrs-----------..---------....---------------------...-------------.......----------------------------------.....-------------------------------------------......................................------....----------------.....--------------------------.-----------------------------------------.--------------------------.-----.---------------...----------------------TLYNSTIPAWAYVKV.FQS.DYFeLQQ....AI..NIGVSST................ATPSS.TSTPTPTPT.PENQTSNNIAIIVGAVLGGIGF..ILL-LITVFFCFLRRRQRKWEE-.....-------------------..-----------------------..----------negvnrpdstfiig...............................
A0A0D9Z4K8_9ORYZ/4-93                ...............................................pgvsastfkspvfig-----------..---------....---------------------...-------------.......----------------------------------.....-------------------------------------------......................................------....----------------.....--------------------------.-----------------------------------------.--------------------------.-----.---------------...-------------------------------------.---.---.---....--..-------................-----.---------.-----------LLAVMCVAVVL..LLHHCVLVTFCDTRRRRRRRRRW.....GVTAQQQQHVQQGEEGDEG..--DDEDDDEDDDDE---------..----------mmssssqakl...................................
A0A0K6FLA4_9HOMO/141-247             ....................................gaypsatapqtrltqvtvtgtpisss-----------..---------....---------------------...-------------.......----------------------------------.....-------------------------------------------......................................------....----------------.....--------------------------.-----------------------------------------.--------------------------.-----.---------------...-------------------------------------.---.---.---....--..-------................----T.TSSTPSLES.NNNNTRSNLGPILGAVFGALAL..LCAIGLGVWVALRKRRRKRVVS-.....-------------------..-----------------------..----------qvpgltksefdaentrtthysastyhp..................
A0A0K6FND4_9HOMO/239-331             .........................................................tassi-----------..---------....---------------------...-------------.......----------------------------------.....-------------------------------------------......................................------....----------------.....--------------------------.-----------------------------------------.--------------------------.-----.---------------...-------------------------------------.---.---.---....--..-IGLPST................TNQDP.SATGSHINS.GSNTKSVKAPIIASVVGGVALV..L-CVLLILY-CIYRRQRRRRAN-.....-SRPMGEIQQYQ-------..-----------------------..----------ygapsnnlqahqgva..............................
GE_VZVD/190-616                      ...........................................................riy----GVRYTET..WSFLPSLTCtgdaAPAIQHICLKHTTCFQDVVVD...VDCAENTKEDQLA.......--EISYRFQGKKEADQPWIVVNTSTLFDELELDPpeiepGVLKVLRTEKQYLGVYIWNMRGSDGTSTYATFLVTWKGDEKT-......................................RNPTPA....---VTPQPRGAEFHMW.....NYHSHVFSVGDTFSLAMHLQYKIHE-.APFDLLLEWLYVPIDPTCQPMRLYSTCLYHPNAPQCLSHMN.SGCTFTSPHLAQRVASTVYQNCEHADnYTAYC.LGISHMEPSFGLILH...DGGTTLKFVDTPESLSGLYVFVVYFNGHVEAVAYTVV.STV.DHF.VNA....IE..ERGFPPT................AGQPP.ATTKPKEIT.PVNPGTSPLLRYAAWTGGLAAV..VLLCLVIFLICTAKRMRVKAYRV.....DKSPYNQSMYYAGLPVDDF..-----EDSESTDTEEEFGNAI--..GGSHGGSSYT.............................................
S7RXH1_GLOTA/131-264                 ...........................................................sgt-----------..---------....---------------------...-------------.......----------------------------------.....-------------------------------------------......................................------....----------------.....--------------------------.-----------------------------------------.--------------------------.-----.---------------...---------------------------KVPAWAYLNV.SNDlWDY.LSA....QA..DLSAPEStatvqkstgsvapstaNPSST.SSSVPSGGA.TSSHNSNTGAIAGGVVGGVVGL..AIIGGLIAFFVMRSRRRSQPKAAsamfeQRPMSAATTEYTAVP----..-----------------------..----------pftpstt......................................
N4TXY7_FUSC1/1-90                    ........................................................matndn-----------..---------....---------------------...-------------.......----------------------------------.....-------------------------------------------......................................------....----------------.....--------------------------.-----------------------------------------.--------------------------.-----.---------------...-------------------------------------.---.---.---....--..-------................-----.--------N.DNNTGFSFGAQPFAWVLIPLFV..ILVLGLTATIIQVRRRRRRRGNQ.....WPGQNTGAPVYTGLRGGR-..-----------------------..----------rtgnrrspwngtrseeglne.........................
L8WV56_THACA/77-175                  .....................................sgsypsatapqtgvaeatatsstsa-----------..---------....---------------------...-------------.......----------------------------------.....-------------------------------------------......................................------....----------------.....--------------------------.-----------------------------------------.--------------------------.-----.---------------...-------------------------------------.---.---.---....--..-------................----L.PTASSISES.GSGNSRSNLGPILGAVFGTLAL..LGVLGLGVWAILRRRRRKRVTH-.....-------------------..-----------------------..----------qelaegvdldrkntrenhgl.........................
GE_HHV2H/57-501                      ..............................................................PLDACGPLRPS..WVALWPPRR....--------------VLETVVD...AAC----MRAPEP.......LAIAYSPPFPAGDEGLYS----ELAWRDRVAVVN.....ESLVIYGALETDSGLYTLSVVGLSDEARQVASVVLVVEPAPVPtptpddydeeddagvtn...arrsafppqppprrppvaPPTHPR....VIPEVSHVRGVTVHME.....TLEAILFAPGETFGTNVSIHAIAHDD.GPYAMDVVWMRFDVPSSCADMRIYEACLYHPQLPECLSPAD.APCAVSS--WAYRLAVRSYAGCSRTT.PPPRC.FAEARMEPVPGLAWL...ASTVNLEFQHASPQHAGLYLCVVYVDDHIHAWGHMTI.STA.AQY.RNA....VV..EQHLPQR................QPEPV.EPTRPHVRA.PHPAPSARGPLRLGAVLGAALL..LAALGLSAWACMTCWRRRSWRAV.....KSRASATGPTYIRVADSEL..YADWSSDSEGERDGSLWQDPPERpdSPSTNGSGFE.............................................
A0A067NXM1_PLEOS/175-307             ...........................................................svq-----------..---------....---------------------...-------------.......----------------------------------.....-------------------------------------------......................................------....----------------.....--------------------------.-----------------------------------------.--------------------------.-----.---------------...----------------------------------TTI.ITS.SQS.QAV....IItsDSGIPYTss............mtSSEPS.KLTPTNNVE.PQRRRSDRLPIILGSVSGALGL..FVVCLLG-WLIYARRRRRKRRRS.....-------------------..-----------------------..----------lqvnwdhfyewksryssgsivkveeleeetleegktprwpepqeg
E7F3K4_DANRE/281-411                 ..................................................rtavlktsaeih-----------..---------....---------------------...-----NHDQIEWR.......FNYKRFPIAEIKDEQISTSDGPDGIFKDRLELDKk...tGSLTIKNISQEHAGFYQLNIMNSRLALRVKTFIVSVDAEKVTIv...................................erRAAVLK....NCPEIQTDDQI-----.....--------------------------.-----------------------------------------.--------------------------.-----.---------------...-------------------------------------.---.---.---....--..-------................-----.---------.----------------------..-----------------------.....-------------------..-----------------------..----------ewwfnesliaei.................................
X0CHY7_FUSOX/1-90                    ........................................................matndn-----------..---------....---------------------...-------------.......----------------------------------.....-------------------------------------------......................................------....----------------.....--------------------------.-----------------------------------------.--------------------------.-----.---------------...-------------------------------------.---.---.---....--..-------................-----.--------N.DNNTGFSFGAQPFAWVLIPLFV..ILVLGLTATIIQVRRRRRRRGNQ.....WPGQNTGAPVYTGLRGGR-..-----------------------..----------rtgnrrspwngtrseeglne.........................
A0A0M3D2F2_9MICO/131-215             .................................................tvgdegaateeps-----------..---------....---------------------...-------------.......----------------------------------.....-------------------------------------------......................................------....----------------.....--------------------------.-----------------------------------------.--------------------------.-----.---------------...-------------------------------------.---.---.---....--..--AAPTT................AAPTA.EQTASPEVTsTPTANADDEAGGSAAIWIVAILavLVVAGVVVWIVMSRRRGAAAT--.....-------------------..-----------------------..----------dsdtpse......................................
GE_PSHV1/44-516                      ..............................................................SLRRTLPAGGTfkWVLVLSDPC....APKPTEICVSVGHCFYDLVSSdndSECANKDRRVLTLalltkskTGELRVIGPMAASSALVGDAGELEQLRRRVSAGMgltddGDISFAAADKVNEGLYGVRVMGSGDSYTFFNVTVATETAGDDR......................................DLATVRhvdiAHNIVPSEDRDHVFVS.....MPRMHVAWPHGTTVLHPKMIIAAASWrPEYNFTYEWYAVPYDGYCATMRLFEACLYHPSAPACLDPAGhRGCVVGTMTHDDLVGRVLMARCRGS-.DLRTCePHVIHIKQKPMVSLG...RAVPELRVESAAHIPS-LYILVVKIDDSVAGWAYTEL.MAE.GSS.PRV....VI..DIHMPRPtsaqggi..aalreieNDDSA.PSLGSNEGG.GPGNSKRRAAVLGAAVWIALTL..LILGGLGAYVAVNKKCLRDKRQWlrgsrKPTLETHAHTYTSLPVGGDlsLEQDAEDEDEDEEELLYERER--..RRSSSGSKK-s............................................
A0A067N107_9HOMO/121-258             ................................................anlktvggypptip-----------..---------....---------------------...-------------.......----------------------------------.....-------------------------------------------......................................------....----------------.....--------------------------.-----------------------------------------.--------------------------.-----.---------------...------------------------ANTSVPAWAFIDP.SST.STF.NQTqakeIA..DQHQPDIr..............gNNGNS.HPGAPASAG.GKSHNSNTGAIVGGVIGGLVLV..VLFVTGISYLLYNRRKRLQAQTT....hQPQAIQTM-----------..-----------------------..----------gtltsyepsdtvsspmppd..........................
A0A0D2XMZ9_FUSO4/1-90                ........................................................matndn-----------..---------....---------------------...-------------.......----------------------------------.....-------------------------------------------......................................------....----------------.....--------------------------.-----------------------------------------.--------------------------.-----.---------------...-------------------------------------.---.---.---....--..-------................-----.--------N.DNNTGFSFGAQPFAWVLIPLFV..ILVLGLTATIIQVRRRRRRRGNQ.....WPGQNTGAPVYTGLRGGR-..-----------------------..----------rtgnrrspwngtrseeglne.........................
W9CQV2_9HELO/158-246                 ..........................................laiipttltslssspsstqv-----------..---------....---------------------...-------------.......----------------------------------.....-------------------------------------------......................................------....----------------.....--------------------------.-----------------------------------------.--------------------------.-----.---------------...-------------------------------------.---.---.---....--..----PLT................NDPAAgTSTTPRPTT.SSHSSSSHVGVYVGAAVGGAIL..F-LLLLIAIICLSRRRRRKHPK-.....-------------------..-----------------------..----------hhpdrpaf.....................................
W4ZDP8_STRPU/215-337                 .....................................ttnetssssviptspdastafdnrt-----------..---------....---------------------...-------------.......----------------------------------.....-------------------------------------------......................................------....----------------.....--------------------------.-----------------------------------------.--------------------------.-----.---------------...-------------------------------------.---.---.---....--..-------................-----.-EESDESTT.PLTTRSTKSVLYAGAGGGGAFL..LILI-IIIIVVVTCRRRNKEKR-.....-SRATDHPLTTMIASKDDN.kERSRPADEEEDP-----------..----------cyenksaetergyenm.............................
GE_GAHVM/41-479                      ..............................................................PVVDGTLYTET..WTWIPNHCN....ETATGYVCLESAHCFTDLILG...VSCMRYADEIVLR.......TDKFIVDAGSIKQIESLSLNGVPNIFLSTKASNK.....--LEILNASLQNAGIYIRYSRNGTRTAKLDVVVVGVLGQARD-......................................RLPQMS....-SPMISSHADIKLSLK.....NFKALVYHVGDTINVSTAVILGPSP-.EIFTLEFRVLFLRYNPTCKFVTIYEPCIFHPKEPECITTAEqSVCHFASNIDILQIAAARSENCST--.GYRRC.IYDTAIDESVQARLTfiePGIPSFKMKDVQVDDAGLYVVVALYNGRPSAWTYIYL.STV.ETY.LNV....YE..NYHKPGFgyksfl....qnssivDENEA.SDWSSSSIK.RRNNGTIIYDILLTSLSIGAII..IVIVGGVCIAILIRRRRRRRTR-.....--GLFDEYPKYMTLPGNDL.gGMNVPYDNTCSGNQVEYYQEKSA..KMKRMGSGYT.............................................
A0A0K6FQJ8_9HOMO/100-256             ...................tpcicttvmynivagcaacqhqlstkvtrnwvnwgtwsalcqn-----------..---------....---------------------...-------------.......----------------------------------.....-------------------------------------------......................................------....----------------.....--------------------------.-----------------------------------------.--------------------------.-----.---------------...----------RDSIQDGIWNRVTGYNDTIPAWAYTKV.FQS.DLFdLQQ....AI..NIGVSST................ATPSS.TSTPTTTSV.PQTQPSNKVPIIVGAVLGGVGL..ILIS-ITILFCILRHRQRKWEE-.....-------------------..-----------------------..----------segvnrpdstf..................................
S7UX88_TOXGO/32-168                  ........................................................taavvs-----------..---------....---------------------...-------------.......----------------------------------.....-------------------------------------------......................................------....----------------.....--------------------------.-----------------------------------------.--------------------------.-----.---------------...-------------------------SDTVSATDSIYAaSPV.HSS.GVA....VE..AKHQGTR................AADPL.VTSKSSPLT.KKAEALRRRRITTA-ASVGAVL..TAVLGLLVAVAKLQQCRRKLVT-.....DSNGTTEGHTRRRLADGGD..DEDDCV-----------------..----------eevcilgdevsprsqkaa...........................
#=GC SS_cons                         ..............................................................XXXXXXXXXXX..XXXXXXXXX....--------------XXXXXXX...XXX----XXXXXX.......XXXXXXXXXXXXXXXXXX----XXXXXXXXXXXX.....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--SEEEEEE.....--SEEE--TT--EE---EEEEEESSS.--EEEEEEEEEE---TT-SEEEEEHHHHH-TTSHHHHS-TT.GGGEE-----SS-SEEEEEEEEBSSS.-TTTT.EEEEEE---TTEEE-...SS-SSEEESS--GGG-EEEEEEEEETTEEEEEEEEEE.E-T.TT-.-EE....EE..E---XXX................XXXXX.XXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXX.....XXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.............................................
#=GC seq_cons                        .........................................................s.s.s.....................................................................................................................................................................................................................................................................................................................................................................................................................................t...s..ss.st..s.spspspsphshhhuslhsshhl..lllhslsshhshh+RRRR+htp...........tt.................................................p..sppt......................................
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