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Database: Pfam
Entry: Herpes_gI
LinkDB: Herpes_gI
Original site: Herpes_gI 
#=GF ID   Herpes_gI
#=GF AC   PF01688.15
#=GF DE   Alphaherpesvirus glycoprotein I
#=GF AU   Bashton M, Bateman A
#=GF SE   Pfam-B_1222 (release 4.1)
#=GF GA   20.70 20.70;
#=GF TC   20.70 179.00;
#=GF NC   20.10 20.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   8764058
#=GF RT   Biosynthesis of glycoproteins E and I of feline herpesvirus:
#=GF RT   gE-gI interaction is required for intracellular transport. 
#=GF RA   Mijnes JD, van der Horst LM, van Anken E, Horzinek MC, Rottier
#=GF RA   PJ, de Groot RJ; 
#=GF RL   J Virol 1996;70:5466-5475.
#=GF RN   [2]
#=GF RM   8207390
#=GF RT   Identification of the feline herpesvirus type 1 (FHV-1) genes
#=GF RT   encoding glycoproteins G, D, I and E: expression of FHV-1
#=GF RT   glycoprotein D in vaccinia and raccoon poxviruses. 
#=GF RA   Spatz SJ, Rota PA, Maes RK; 
#=GF RL   J Gen Virol 1994;75:1235-1244.
#=GF RN   [3]
#=GF RM   8207795
#=GF RT   Unusual phosphorylation sequence in the gpIV (gI) component of
#=GF RT   the varicella-zoster virus gpI-gpIV glycoprotein complex (VZV
#=GF RT   gE-gI complex). 
#=GF RA   Yao Z, Grose C; 
#=GF RL   J Virol 1994;68:4204-4211.
#=GF DR   INTERPRO; IPR002874;
#=GF CC   This family consists of glycoprotein I form various members of
#=GF CC   the  alphaherpesvirinae these include herpesvirus,
#=GF CC   varicella-zoster virus and pseudorabies virus. Glycoprotein I
#=GF CC   (gI) is important during natural  infection, mutants lacking gI
#=GF CC   produce smaller lesions at the site of infection and show
#=GF CC   reduced neuronal spread [1]. gI forms a heterodimeric complex
#=GF CC   with gE; this complex displays Fc receptor activity (binds to 
#=GF CC   the Fc region of immunoglobulin) [1]. Glycoproteins are also
#=GF CC   important  in the production of virus-neutralising antibodies
#=GF CC   and cell mediated  immunity [2]. The alphaherpesvirinae have a
#=GF CC   dsDNA gnome and have no RNA stage during viral replication.
#=GF SQ   5
#=GS GI_GAHVM/2-157  AC Q9E6L5.1
#=GS GI_HHV11/8-165  AC P06487.1
#=GS GI_VZVD/7-164   AC P09258.1
#=GS GI_PSHV1/7-159  AC Q6UDF5.1
#=GS GI_HHV2H/8-165  AC P13291.1
GI_GAHVM/2-157             ..YLLQLLFWIRLFRgiwSIVYTGTSVTLSTDQSALVAFCGL..DKMVN--..VRGQLLFLGDQTRT-SSYTGTTEILKWD.EEYKCYSVLHATSYMDCPAIDATVFRGCR--DAVV...YAQPHDRVQPFPEkgtLLRIVEPRVSDTGSYYIRVALAGRNMSDIFRMAVI..
GI_HHV11/8-165             .g-LVLVGLWVCAT-...SLVVRGPTVSLVSNSFVDAGALGP..DGVVEEDllILGELRFVGDQVPHTTYYDGGVELWHYP.MGHKCPRVVHVVTVTACPRRPAVAFALCRATDSTHspaYPTLELNLAQQP-...LLRVQRATRDYAGVYVLRVWVGDAPNASLFVLGMA..
GI_VZVD/7-164              .l-ISAVIFYIQVTN...ALIFKGDHVSLQVNSSLTSILIPMqnDNYTE--..IKGQLVFIGEQLPTGTNYSGTLELLYAD.TVAFCFRSVQVIRYDGCPRIRTSAFISCRYKHSWH...YGNSTDRISTEPDagvMLKITKPGINDAGVYVLLVRLDHSRSTDGFILGVN..
GI_PSHV1/7-159             sq--AAVAIFLALVTcclGTVIKGLGVSGVFEDTLVVF----..EKVETED..VGARLVFLGDQRPK-NPYGGTVRVLFQPgESGTCSIPLLQVRYSNCTNTSAAVFSGCYRTDTE-...FSVPRANRGTSPG...FVSLRTPTMLDSGDIYVTVHLDHLPRPDAFRIK--fv
GI_HHV2H/8-165             .g-LAILGLWVCAT-...GLVVRGPTVSLVSDSLVDAGAVGP..QGFVEEDlrVFGELHFVGAQVPHTNYYDGIIELFHYP.LGNHCPRVVHVVTLTACPRRPAVAFTLCRSTHHAHspaYPTLELGLARQP-...LLRVRTATRDYAGLYVLRVWVGSATNASRFVLGVA..
#=GC seq_cons              .t.LutVulWlslTp...uLVl+GsoVSLVo-SolsuuhlG...DshVEED..VtGcLlFlGDQlP+sosYsGTlELL+aP.pus+CsRVVHVVoYouCPRpsAsAFsuCRtTDosH...YusscssluspPt...LLRlpcPThsDAGlYVLRVaLucussuDtFlLGVs..
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