GenomeNet

Database: Pfam
Entry: Herpes_glycop
LinkDB: Herpes_glycop
Original site: Herpes_glycop 
#=GF ID   Herpes_glycop
#=GF AC   PF01528.14
#=GF DE   Herpesvirus glycoprotein M
#=GF AU   Bateman A
#=GF SE   Pfam-B_929 (release 4.0)
#=GF GA   25.00 25.00;
#=GF TC   250.90 250.60;
#=GF NC   23.00 22.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   8764089
#=GF RT   Identification and characterization of pseudorabies virus
#=GF RT   glycoprotein gM as a nonessential virion component. 
#=GF RA   Dijkstra JM, Visser N, Mettenleiter TC, Klupp BG; 
#=GF RL   J Virol 1996;70:5684-5688.
#=GF RN   [2]
#=GF RM   7653096
#=GF RT   Identification and molecular characterization of the murine
#=GF RT   cytomegalovirus homolog of the human cytomegalovirus UL100 gene. 
#=GF RA   Li W, Eidman K, Gehrz RC, Kari B; 
#=GF RL   Virus Res 1995;36:163-175.
#=GF DR   INTERPRO; IPR000785;
#=GF CC   The herpesvirus glycoprotein M (gM) is an integral membrane
#=GF CC   protein predicted to contain 8 transmembrane segments [2].
#=GF CC   Glycoprotein M is not essential for viral replication [1].
#=GF SQ   14
#=GS GM_HHV6U/1-342   AC Q04630.1
#=GS GM_ALHV1/1-368   AC O36388.1
#=GS GM_PSHV1/9-398   AC Q6UDH4.1
#=GS GM_EBVA8/1-368   AC Q1HVE9.1
#=GS GM_HHV6Z/1-342   AC P52449.1
#=GS GM_EHV2/1-354    AC P52371.1
#=GS GM_HCMVM/1-361   AC Q6SW43.1
#=GS GM_VZVD/26-401   AC P09298.1
#=GS GM_HHV2H/21-384  AC P89433.1
#=GS GM_HHV8P/1-357   AC F5HDD0.1
#=GS GM_HHV11/19-384  AC P04288.1
#=GS GM_GAHVM/13-390  AC Q9E6Q6.1
#=GS GM_EBVB9/1-368   AC P03215.1
#=GS GM_SHV21/2-361   AC Q01017.1
GM_HHV6U/1-342              ....MASSRVDTINLRIWLVSIICAALSFINVTVYLIAINFPNL.GFPCAYFEINDLKAVNLS......ANNQIYQMTHQLYINPVQIICYVLIMAMLFLLIIIYYIVCCAKV.FS-SNKT.SNVNQTTRDITW-MGDT.SSCFQFILIMDTFQLFVTALSFRLVALGAFAYCIFFVCFTTFNVTLITQ------FQSADKSFFAFQKIHPNLKGTVqfKTVVINLTELMLGYSTMFLGITTCLGVGNSIYIRSITVAYSSINTFLVMACIYSIVIEAVLVRYVKPLFGYYVGMFCGAVGLSFPILQYETFFE-------SEWSTGLIINLAVIAIISIGFIICRLVRYLVKKKRRYKQLV...----------------------------ntessslmde.....................
GM_ALHV1/1-368              ....MKSSKKDIFILHIWLKLMGCYVFMFITSVVLPIAAMFPNL.GFPCYYNTLVDYSKLNLR......EKNQAQHLTPTLFLEAPEMFFYVTYSFIVDCCSLVYYALAAVAV.VKAKKHA.PGLMALSQWIMA-VGSP.TLLYMAVLKLWTIQLYIHTLSYKHIYLAAFVYCLHWLLSMVYTECYITNVSSQWTSSELKKTIPE-NILLYRVVHVL..KPIMMNVHLSVVALETLIFCLSFMMAIGNSFYVMVSDIVFGAINLYLILPIIWYFVTEFWLSKYLPRQFGFYFGVLVASIILILPVVRYDKIFV------AAQIHRAVSINIAMIPLCALVALLVRACRVYTDRKKIAYTALpskPQTIKYTKPIEPSTKQAPDSSIFLEEE-s..............................
GM_PSHV1/9-398              ...q--ESRLERISWRMWMVEAACYIVLVLLTLVSSFASLSSTT.GFPCFVGTVGESSFGGDLmghgmtPARRDG--VKIFFMSSPSTLFVVFSAVFVWLVVAVY-LLLGGVR.VKMCNFD.SSYGASE--LSSAVATM.TSLVTLSITAWAWQVFVLMLSYRQLTLAAVAFVGIFIAGLVFMLSFASGGKSPENYATFNSQLKTVCKDVHAVITAF..KAVVLNLFCVVFGVWHLMLVMLGAVIMVLNFGVSIPKATTGALVVFIVLGLVYLMMIELVVSRYVHVLLGPHLGMIIALGIAGTSALSYAETLDEIMYASWKPVAAGI---LGAFSVIVLALAVLRAVRSYKFHKAAQSKFL...QQVASVAQTVKNRARRERNGPRVHKR--yydavpvdayeddpyrqsprrs.........
GM_EBVA8/1-368              ....MKSSKNDTFVYRTWFKTLVVYFVMFVMSAVVPITAMFPNL.GYPCYFNALVDYGALNLT......NYNLAHHLTPTLYLEPPEMFVYITLVFIADCVAFIYYACGEVAL.IKARKKV.SGLTDLSAWVSA-VGSP.TVLFLAILKLWSIQVFIQVLSYKHVFLSAFVYFLHFLASVLHACACVTRFSPVWVVKAQDNSIPQ-DTFLWWVVFYL..KPIVTNLYLGCLALETLVFSLSVFLALGNSFYFMVGDMVLGAVNLFLVLPIFWYILTEVWLASFLRHNFGFYCGMFIASIILILPLVRYEAVFV------SAKLHTTVAINVAIIPILCSVAMLIRICRIFKSMRQGTDYVPvseTVELELESEPRPRPSRTPSPGRNRRRSS...............................
GM_HHV6Z/1-342              ....MASSRVDTINLRIWLVSIICAALSFINVTVHLIAINFPNL.GFPCAYFEINDLKAVNLS......ANNEIYQMTHQLYINPVQIICYVLIMAILFLLIIIYYIVCCAKV.FS-SNKT.SNVNQTTRDITW-MGDT.SSCFQFILIMDTFQLFVTALSFRLVALGAFAYSIFFVCFTTFNVTLITQ------FQSADKSFFAFQKIHPNLKGTVqfKTVVINLSELMLGYSTMFLGITTCLGVGNSIYIRSITVAFSSINTFLVMACIYSIVIEAVLVRYVKPLFGYYVGMFCGAVGLSFPILQYETFFE-------SEWSTGLIINLSVVAIISIGFIICRLVRYLVKKKRRYKQLL...NA--------------------------essslmde.......................
GM_EHV2/1-354               ....MKSSKSDLFIYKTWFKLLVLYFVMFVLSATVPIAASFPGL.GFPCYYNALVNYSAINLT......ERNVAKHLTPTLYLEEPEMFAYMTFTFLVDCFAAVYYFLGALAImLAKRHFV.VSLTTLSQWIAM-VGTP.TLILIGMWRMWTIQLFIQTLSYKHIYLSAFVYLIHFLLSFLHTQCYISRNSQLWSLKVLEQGIPP-NTLLDTVVFTI..KPLLANCQLFCLGLEMLVFSLSFMMAIGNSFYVLVSDIVFGAINLYLALVLFWVLLTELYLVKYMTFVMGFYLGGLIGCIFLLVPLWRYEQIFV------AANLRSPILINILVIFFLCTLSALVRLLRMTWFS--------...----------------------------ptkpsyepiqlknikhrrvklqsp.......
GM_HCMVM/1-361              ....MAPSHVDKVNTRTWSASIVFMVLTFVNVSVHLVLSNFPHL.GYPCVYYHVVDFERLNMS......AYNVMHLHTPMLFLDSVQLVCYAVFMQLVFLAVTIYYLVCWIKI.SMRKDKG.MSLNQSTRDISY-MGDS.LTAFLFILSMDTFQLFTLTMSFRLPSMIAFMAAVHFFCLTIFNVSMVTQ------YRSYKRSLFFFSRLHPKLKGTVqfRTLIVNLVEVALGFNTTVVAMALCYGFGNNFFVRTGHMVLAVFVVYAIISIIYFLLIEAVFFQYVKVQFGYHLGAFFGLCGLIYPIVQYDTFL-------SNEYRTGISWSFGMLFFIWAMFTTCRAVRYFRGRGSGSVKYQ...ALATASGEEVAALSHHDSLESRRLREE-e..............................
GM_VZVD/26-401              ..ld---HQMDTLNWRIWIIQVMMFTLGAVMLLATLIAASSEYT.GIPCFYAAVVDYELFNATldggvwSGNRGGYSAPVLFLEPHSVVAFTYYTALTAMAMAVYTLITAAII.HRETKNQ.RVRQSSG--VAWLVVDP.TTLFWGLLSLWLLNAVVLLLAYKQIGVAATLYLGHFATSVIFTTYFCGRGKLDETNIKAVANLRQQSVFLYRLAGPT..RAVFVNLMAALMAICILFVSLMLELVVANHLHTGLWSSVSVAMSTFSTLSVVYLIVSELILAHYIHVLIGPSLGTLVACATLGTAAHSYMDRLYDPISVQSPRLIPTTRGTLACLAVFSVVMLLLRLMRAYVYHRQKRSRFY...GAVRRVPERVRGYIRKVKPAHRNSRRT-n..............................
GM_HHV2H/21-384             .gar--------AAWWVWCVQVATFIVSAICVVGLLVLASVFRD.RFPCLYAPATSYAKANAT......VEVRGGVAVP-LRLDTQSLLATYAITSTLLLAAAVY-AAVGAVT.SR---YE.RALDAARRLAAARMAMPhATLIAGNVCAWLLQITVLLLAHRISQLAHLIYVLHFACLVYLAAHFCTRGVLSGTYLRQVHGLIDPAPTHHRIVGPV..RAVMTNALLLGTLLCTAAAAVSLNTIAALNFNFSAPSMLICLTTLFALLVVSLLLVVEGVLCHYVRVLVGPHLGAIAATGIVGLACEHYHTGGYYVVEQQWPGAQTGVRVALALVAAFALAMAVLRCTRAYLYHRRHHTKFF...VRMRDTRHRAHSALRRVRSSMRGSRR--gg.............................
GM_HHV8P/1-357              ....MRASKSDRFLMSSWVKLLFVAVIMYICSAVVPMAATYEGL.GFPCYFNNLVNYSALNLT......VRNSAKHLTPTLFLEKPEMLVYIFWTFIVDGIAIVYYCLAAVAV.YRAKHVH.ATTMMSMQSWIALLGSH.SVLYVAILRMWSMQLFIHVLSYKHVLMAAFVYCIHFCISFAHIQSLITCNSAQWEIPLLEQHVPD-NTMMESLLTRW..KPVCVNLYLSTTALEMLLFSLSTMMAVGNSFYVLVSDAIFGAVNMFLALTVVWYINTEFFLVKFMRRQVGFYVGVFVGYLILLLPVIRYENAFV------QANLHYIVAINISCIPILCILAIVIRVIRS------------...----------------------------dwglctpsaaymplatsaptvdrtptvhqkp
GM_HHV11/19-384             mtga----RT---AWWVWCVQVATFVVSAVCVTGLLVLASVFRA.RFPCFYATASSYAGVNST......AEVRGGVAVP-LRLDTQSLVGTYVITAVLLLAVAVY-AVVGAVT.SR---YD.RALDAGRRLAAARMAMPhATLIAGNVCSWLLQITVLLLAHRISQLAHLVYVLHFACLVYFAAHFCTRGVLSGTYLRQVHGLMELAPTHHRVVGPA..RAVLTNALLLGVFLCTADAAVSLNTIAAFNFNFSAPGMLICLTVLFAILVVSLLLVVEGVLCHYVRVLVGPHLGAVAATGIVGLACEHYYTNGYYVVETQWPGAQTGVRVALALVAAFALGMAVLRCTRAYLYHRRHHTKFF...MRMRDTRHRAHSALKRVRSSMRGSRDG-r..............................
GM_GAHVM/13-390             ..gl---SHIDYVHKKMWVVQAVCFGIAVLVFFGTLVAASINLTeGFPCFFAAVVDYRTVNTTlvhtglTYPRLGGVVPVLFFQTKAVVFFFYATSIVFVFLVCY-ITVGAII.SSKKHVG.AAYMGSGAFVFSLMASP.LTILLGTVSIWLLQAVVIVLAHKLIVLAAAVYLVHFSTITFFYGYFCGRGVDSKVYAEDISSAKDIDGSLHKLIGNV..RAMMVNLLSIVYSIILIMSSLMFGMLLANSFTLKFWHVIVTVLITTSVLTLIYLLVIEFLIARYVHIILGAYIGLLIGYGMLWTTTCDYVNRFYYAMGANASNLRIACHSVLAVFTVLILLAMVVRLIRASLYHRRRSTRAY...AKAMKLQQNVKHRLRQLRRSYKQRGSQ-s..............................
GM_EBVB9/1-368              ....MKSSKNDTFVYRTWVKTLVVYFVMFVMSAVVPITAMFPNL.GYPCYFNALVDYGALNLT......NYNLAHHLTPTLYLEPPEMFVYITLVFIADCVAFIYYACGEVAL.IKARKKV.SGLTDLSAWVSA-VGSP.TVLFLAILKLWSIQVFIQVLSYKHVFLSAFVYFLHFLASVLHACACVTRFSPVWVVKAQDNSIPQ-DTFLWWVVFYL..KPVVTNLYLGCLALETLVFSLSVFLALGNSFYFMVGDMVLGAVNLFLILPIFWYILTEVWLASFLRHNFGFYCGMFIASIILILPLVRYEAVFV------SAKLHTTVAINVAIIPILCSVAMLIRICRIFKSMRQGTDYVPvseTVELELESEPRPRPSRTPSPGRNRRRSS...............................
GM_SHV21/2-361              ....MKASRSDTFMLRTWIQLLVLFVIMFIMSAILPIAASVEGL.GFPCYFPNLVDYSLLNLT......LRNAAKHLTPTLFLEAPELFVYITWSVLVDLASAIYYVVGALAI.LQARKTHlTSMITLQTWINL-VGSH.TMLFIGIARMWTLQLFIHVLSYKHVMLAAFIYFLHFCLSYMHTLSLVSRNSPKWSVLLMEQHIPK-QSLLSTILDYG..KPLCVNMYLSLLALEMLVFSLGFMMAIGNSFYILVSDTVLASINLYFVLTTFWYMMTEMFLQDYLKLQFGFYLGVFSGSLILLLPVLRYEAVFV------SANLHKTVAVNIAMIPAMCVIAMMFRLFRYSQQVRKPENSYT...PLPKRFKKR-------------------rqkqdqqlimvet..................
#=GC seq_cons               ....MtsS+sDphsh+hWhhplssaslhalhsslh.lAAshssL.GFPCaasslVDYutlNhT......stNputthTPhLaL-ssphlsYhhhshll.hsshlYYhlsussl.hptpchs.sulssssp.lsh.hGss.osLahullphWolQlFlhsLSa+hlhLuAFlYhlHFhs.shassshlTpss..hshtphcpul.p.sshh.pllssl..KslhsNLhhhslulpplhhulohhhulGNSFalhsschlhuulslFhlLslhahllsEhhLs+Yl+h.hGaYlGhhhushhLhhPllcY-shFh......tuplpssltlslAhlsllslshhllRlsRhhhh++ptpsphh...sh.hphtpp.t...pp.....h..tp..p..............................
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