GenomeNet

Database: Pfam
Entry: ICEA
LinkDB: ICEA
Original site: ICEA 
#=GF ID   ICEA
#=GF AC   PF05315.6
#=GF DE   ICEA Protein
#=GF AU   Moxon SJ
#=GF SE   Pfam-B_2792 (release 7.7)
#=GF GA   19.00 19.00;
#=GF TC   21.10 20.70;
#=GF NC   18.00 17.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11843964
#=GF RT   Distribution of distinct vacA, cagA and iceA alleles in
#=GF RT   Helicobacter pylori in Hong Kong. 
#=GF RA   Wong BC, Yin Y, Berg DE, Xia HH, Zhang JZ, Wang WH, Wong WM,
#=GF RA   Huang XR, Tang VS, Lam SK; 
#=GF RL   Helicobacter 2001;6:317-324.
#=GF DR   INTERPRO; IPR007979;
#=GF CC   This family consists of several ICEA proteins from Helicobacter
#=GF CC   pylori. Helicobacter pylori infection causes gastritis and
#=GF CC   peptic ulcer disease, and is classified as a definite carcinogen
#=GF CC   of gastric cancer. ICEA1 is  speculated to be associated with
#=GF CC   peptic ulcer disease [1].
#=GF SQ   70
#=GS Q9ZJ16_HELPX/1-153    AC Q9ZJ16.1
#=GS D0W9Y5_NEILA/1-230    AC D0W9Y5.1
#=GS Q9ZJ17_HELPX/1-219    AC Q9ZJ17.1
#=GS B9XVJ5_HELPX/1-66     AC B9XVJ5.1
#=GS Q8VTH4_HELPX/1-227    AC Q8VTH4.1
#=GS F2NRE4_TRES6/188-300  AC F2NRE4.1
#=GS G8DDT3_9VIRU/1-209    AC G8DDT3.1
#=GS E1P4P8_NEILA/3-186    AC E1P4P8.1
#=GS B6JN49_HELP2/1-114    AC B6JN49.1
#=GS H5VFN0_HELBI/1-219    AC H5VFN0.1
#=GS Q8VTH3_HELPX/1-227    AC Q8VTH3.1
#=GS Q84FS0_HELPX/1-227    AC Q84FS0.1
#=GS F4D2J2_HELPX/1-40     AC F4D2J2.1
#=GS Q9ZJ15_HELPX/1-219    AC Q9ZJ15.1
#=GS Q9L676_HELPX/1-177    AC Q9L676.1
#=GS P71406_HELPX/1-177    AC P71406.1
#=GS Q9L9W4_HELPX/1-169    AC Q9L9W4.1
#=GS B9XVJ6_HELPX/1-119    AC B9XVJ6.1
#=GS Q1CS54_HELPH/1-148    AC Q1CS54.1
#=GS I0ZKH4_HELPX/1-171    AC I0ZKH4.1
#=GS F4HDL7_GALAU/1-229    AC F4HDL7.1
#=GS H8AVN4_CAMJU/1-221    AC H8AVN4.1
#=GS E1P4P9_NEILA/1-65     AC E1P4P9.1
#=GS D0ITQ5_HELP1/1-118    AC D0ITQ5.1
#=GS G9XDQ5_9FIRM/187-310  AC G9XDQ5.1
#=GS B6JN48_HELP2/1-127    AC B6JN48.1
#=GS Q1CS55_HELPH/2-81     AC Q1CS55.1
#=GS Q17YX9_HELAH/1-171    AC Q17YX9.1
#=GS E4VJ65_9HELI/1-110    AC E4VJ65.1
#=GS T2N3_NEILA/1-230      AC Q51083.1
#=GS H8H6A9_HELPX/6-104    AC H8H6A9.1
#=GS Q9L9W6_HELPX/1-231    AC Q9L9W6.1
#=GS D7FCC9_HELP3/1-129    AC D7FCC9.1
#=GS H8H6B0_HELPX/1-47     AC H8H6B0.1
#=GS Q7VHB6_HELHP/1-224    AC Q7VHB6.1
#=GS B9XZR6_HELPX/1-129    AC B9XZR6.1
#=GS Q9L9W9_HELPX/1-177    AC Q9L9W9.1
#=GS Q9L677_HELPX/1-227    AC Q9L677.1
#=GS E6NLK6_HELPL/1-227    AC E6NLK6.1
#=GS E1Q3E4_HELPP/1-126    AC E1Q3E4.1
#=GS A7NKK7_ROSCS/77-220   AC A7NKK7.1
#=GS C6S5V1_NEIML/170-308  AC C6S5V1.1
#=GS H8CPY8_CAMJU/1-221    AC H8CPY8.1
#=GS Q8VTH1_HELPX/1-227    AC Q8VTH1.1
#=GS E6NHM8_HELPK/1-231    AC E6NHM8.1
#=GS E8QTJ7_HELPW/1-227    AC E8QTJ7.1
#=GS F4D2J1_HELPX/2-159    AC F4D2J1.1
#=GS E1Q3E5_HELPP/1-88     AC E1Q3E5.1
#=GS E4ZAF0_NEIL0/1-230    AC E4ZAF0.1
#=GS D0ITQ6_HELP1/1-97     AC D0ITQ6.1
#=GS D0K0S6_HELP5/2-167    AC D0K0S6.1
#=GS G2MAL8_HELPX/1-227    AC G2MAL8.1
#=GS A3ZFH3_CAMJU/1-131    AC A3ZFH3.1
#=GS D7FCD0_HELP3/6-96     AC D7FCD0.1
#=GS O25810_HELPY/1-171    AC O25810.1
#=GS E6NSX9_HELPQ/1-119    AC E6NSX9.1
#=GS Q9L9W5_HELPX/1-227    AC Q9L9W5.1
#=GS H7YW12_CAMJU/1-221    AC H7YW12.1
#=GS Q9L9W8_HELPX/1-171    AC Q9L9W8.1
#=GS G1VMJ4_9FIRM/4-103    AC G1VMJ4.1
#=GS B9XZR5_HELPX/6-96     AC B9XZR5.1
#=GS Q9L9W3_HELPX/1-227    AC Q9L9W3.1
#=GS B2CW66_HELPX/1-53     AC B2CW66.1
#=GS E1Q0T2_HELPM/1-227    AC E1Q0T2.1
#=GS Q8VTH0_HELPX/1-227    AC Q8VTH0.1
#=GS Q8VQ95_HELPX/1-227    AC Q8VQ95.1
#=GS E6LAP4_CAMUP/1-132    AC E6LAP4.1
#=GS H8H6C6_HELPX/1-56     AC H8H6C6.1
#=GS Q9L9W7_HELPX/1-227    AC Q9L9W7.1
#=GS I0E5U1_HELPX/1-227    AC I0E5U1.1
Q9ZJ16_HELPX/1-153               ...................................MSKSKKEL.FLELAQPDKTGVSRWVSVTEFIGKYQGLWgVGvpgsNGG.....TWCRGNSSLAKEFNLEFVYRK.AQGNPIDRIRLNGYNTRGVF..NQSIRQDIKNYYKQQCCAMCGARGNCENTQIEVDHK..DGRKDDLRVS....D..SKR.ETF.DDFQALCKACND----------------------..---...------.........------.........-..--------------------------------------------....................................
D0W9Y5_NEILA/1-230               ...................................MKITKTEL.FLRLAKPNEQGISRWVKTSEFAGEYKDLK.LG....NGG.....SWCRKDSPLARDYIVEFDKGL.TSGNSIDAIRLNGFNQEKHF..KQYIRKDIKDALKTRNCVMLGVNGKSENTKIEIDHK..DGRKNNHRVS....D..IKT.QKL.EDFQPLCKAANDVKRQICKTCKETNKRWSAKNIS..GNP...YAFYMG.........DENYSE.........E..LGCVGCYQYDPVEYRKSSVKRIAAEAAKYTSDYIFKKLYEEDNG....................................
Q9ZJ17_HELPX/1-219               ...................................MSQSKKEL.FLELAQPDKNGVSRWVSVTEFVGKYQGLQ.LG....NGG.....SWCRNNSSLAKEFELEFDKGQ.TLGNSIDRIRLNGYKTKGVF..NQNIRQDIKDYYKQQCCAMCGVRGKSENTQIEIDHK..DGRKDDLRVS....D..LNT.QTF.DDFQALCKARNDKKRQICKKCKESGYRFDATKIP..GNR...YPFYEG.........AFEYD-.........-..-GCVGCYQYDPIQYRKTCNDRIFNEGYQIGYNQ-----------ktt.................................
B9XVJ5_HELPX/1-66                ...................................MSKSKKEL.LLELAQPDKNGMSRWVSAIEFIGKYQGLQ.RG....NGG.....SWCRNNSSLAKEFELEFDKRQ.TQ------------------..------------------------------------..----------....-..---.---.----------------------------------..---...------.........------.........-..--------------------------------------------f...................................
Q8VTH4_HELPX/1-227               ...................................MGKSKKEL.FLELAQPDENGVSRWVSVTEFVGKYQGLQ.LS....NGG.....SWCRNNSSLAKEFNLEFDKGQ.TLGNSIDRIRLNGYNTECVF..NQSIRQDIKNHYKQQCCAVCGVRGNSENTQIEVDHK..DGRKDDSRVS....D..SNA.QTF.DDFQALCKACNDKKSQICKKCKESGYRFDATKIP..GNR...YSFYEG.........EAEYD-.........-..-GCVGCYQYDPIQYRKTCNDRIYNEGYQKGYGDGYQIGYHQKTT....................................
F2NRE4_TRES6/188-300             .....................tkkegllpdhkfse--------.-----------------------------.--....---.....---------------------.--------------------..--------------------------------IRWN..DETKRETLEN....L..TDK.EIL.RDFQLLSNQRNQQKREICRNCYQTGKRG---TIY..GIP...F-FYEG.........TENWDSsipkngksaE..KGCIGCAWYDIERWRQELIKK-----------------------lk..................................
G8DDT3_9VIRU/1-209               ...................................MSLSKKHQaIENLFKPNAEGISEWI-TRETIGADEELN.WG....NNG.....VTRGGVLYHYDKYIWEFGRANdKPSGKILKIRLNGLNPEKALnlKRPIREDIHKYHKNMGCVARGS-----TSDLRTDHK..NDLYNDLRVL....N..MKT.QTF.DDFQCLCNHCNLQKRQVSKKTVELGKRYSATNIP..MLSifgVDFTQG.........DETYDK.........DdiNAMVGTYWYDPVAF------------------------------mtylks..............................
E1P4P8_NEILA/3-186               .............................erfsig--------.-----------------------------.--....---.....----------ERLFVEFDKGL.TSGNSIDAIRLNGFNQEKHF..KQYIRKDIKDALKTRNCVMLGVNGKSENTKIEIDHK..DGRKNNHRVS....D..IKT.QKL.EDFQPLCKAANDVKRQICKACKETNKRWSAKNIS..GNP...YAFYMG.........DENYSE.........E..LGCVGCYQYDPVEYRKSSVKRIAAEAAKYTSDYIFKKLYEEDNG....................................
B6JN49_HELP2/1-114               ...................................MSKSKKEL.FLELAQPDKTGVSRWVSVTEFVGKYQGLQ.LG....VPGsngrtSWCRSNSSLAKEFNLEVGYRK.AQGNPIDRIRLNGYNTECVF..NQNIRQDIKNHYKQQCCAVCAA--------------..----------....-..---.---.----------------------------------..---...------.........------.........-..--------------------------------------------tlkt................................
H5VFN0_HELBI/1-219               ..................................m------DL.FLELAQPNTDGFSRWVSVSEFSGKYQELQ.LG....NGG.....SWLRPSSSLAKKYKIEVDKSQ.SSGNSIDRIRLVGFNTEIVF..NQNIRQDIKDFYKNQRCVMLGVCGKSENTKIEIDHK..DGRKNDLRVA....D..VSS.QRL.EDFQSLCKAANDIKRQICKTCKETNLRWNAKNIA..GNP...YAFYAG.........DEHHTD.........E..LGCVGCYQYDPVAYCQECVKKIAKEASEYIYHKIY---------fds.................................
Q8VTH3_HELPX/1-227               ...................................MSKSKKEL.FLELAQPDKTGVSRWVSVTEFVGKYQGLQ.LG....NGG.....SWCRNNSSLAKEFNLEFDKGQ.TLGNSIDRIRLNGYNTECVF..NQSIRQDIKNHYKQQCCTMCGARGNSENTQIEVDHK..DGRKDDLRVS....D..LST.QTF.DDFQALCKACNDKKRQICKECKETGYRFDATKIP..GNH...YPFYEG.........VAEYA-.........-..-GCVGCYQYDPIQYRKTCNDRIYNEGYQKGYYEGYQIGYHQKTT....................................
Q84FS0_HELPX/1-227               ...................................MSESKKEL.FLELAQPDKNGVSRWVSVREFVGKYQGLQ.LG....NGG.....SWCRNNSSLAKEFELEFDKGQ.TLGNSIDRIRLNGYNTRCVF..NQSIRQDIKNYYSQQCCTMCGVRGNSESTQIEVDHK..DGRKNDPRVS....D..LNT.QTF.DDFQALCKACNDKKRQICKKSKESGYRFDATKIP..SNR...YPFYEG.........AFEYD-.........-..-GCVGCYQYDPIQYRKTCNDRIYNEGYQKGYYEGYQIGYHQKTT....................................
F4D2J2_HELPX/1-40                ...................................--------.-MELAQLDKNGVSRWVSAIEFVGKYQGLQ.LG....NGG.....V--------------------.--------------------..------------------------------------..----------....-..---.---.----------------------------------..---...------.........------.........-..--------------------------------------------gvgith..............................
Q9ZJ15_HELPX/1-219               ...................................MSKSKKEL.FLELAQPDKNGMRRWVSVTEFVGKYQGLQ.LG....NGG.....SWCRNNSSLAKEFILEFDKGQ.TLGNSIDRIRLNGYNTRCVF..NQNIRQDIKNYYSQQCCTMCGASGNSENTQIEVDHK..DGRKDDLRVS....D..SNT.QTL.DDFQALCKACNDKKRQIGEKCKENGHRFDATKIP..GNY...YSFYER.........EAEYD-.........-..-GCVGCYQYDPIQYRKTCNDRIFNEGYQIGYHQ-----------ktt.................................
Q9L676_HELPX/1-177               ...................................--------.-----------------------------.--....---.....--------MAKEFILDPDKEQ.TPGNSIDRIRLNGYKTRGVF..NQSIRQDIKNYYKQQCCAMCGARGNSENTQIEVDHK..DDRKDDLRVS....D..LNT.QTF.DDFQALCKACNDKKRQICKKCKESGYRFDATKIP..GNY...YSFYEG.........EAEYD-.........-..-GCVGCYQYDPIQYRKTCNDRIYNEGYQKGYGDGYQIGYHQKTT....................................
P71406_HELPX/1-177               ...................................--------.-----------------------------.--....---.....--------MAKEFNLEFDKGQ.TLGNSIDRIRLNGYNTECVF..NQSICQDIKNHYKQQCCAMCGVRGNSENTQIEVDHK..DGRKDDSRVS....D..LNT.QTF.DDFQALCKACNDKKRQICKKCKESGYRFDATKIP..GNY...YSFYEG.........EAEYD-.........-..-GCVGCYQYDPIQYRKTCNDRIYNEGYQKGYGDGYQIGYHQKTT....................................
Q9L9W4_HELPX/1-169               ...................................--------.-----------------------------.--....---.....--------MAKEFKLEFDKRQ.TPGNSIDRIRLNGYNTRCVF..NQSIRQDIKNYYSQQCCAMCGAHGNSENTQIEVDHK..DGRKDDLRVS....D..LNT.QTF.DDFQALCKACNDKKRQICKKCKESGYRFDATKIP..GNR...YPFYEG.........AIEYD-.........-..-GCVGCYQYDPIQYRKTCNDRIFNEGYQIGYNQ-----------ktt.................................
B9XVJ6_HELPX/1-119               ..................................m--------.-----------------------------.--....---.....---------------------.--------------------..------------------LCGVRGNSENTQIEIDHK..DGRKDDLRVS....D..LNT.QTF.DDFQALCKACNDKKRQICKKCKESGYRFDATKIP..GNR...YPFYEG.........AIKYD-.........-..-GCVGCYQYDPIQYRKTCNDRIFNEGYQIGYNQ-----------ktt.................................
Q1CS54_HELPH/1-148               ...................................MSKSKKEL.FLELAQPDKNGVSRWASVTEFVGKYQGLQ.LG....NGG.....SWFRNNSSLAKEFKLEFDKGQ.TLGNSIDRIRLNGYNTECVF..NQSIRQDIKNYYKQQCCTMCGARGNSENTQIEVDHK..DDRKNDLRVS....D..SNT.QTF.DDFQALYKACND----------------------..---...------.........------.........-..--------------------------------------------....................................
I0ZKH4_HELPX/1-171               ...................................--------.-----------------------------.--....---.....--------------MEFDKGQ.TLGNFIDRIRLNGYNTECVF..NQSICQDIKNHYKQQCCAMCGVRGNSENTQIEVDHK..DGRKDDSRVS....D..LST.QAF.DDFQALCKACNDKKRQICKKCKETGYRFDARKIP..GNH...YSFYEG.........EAEYD-.........-..-GCVGCYQYDPIQYRKTCNDRIYNEGYQKGYSDGYQIGYHQKTT....................................
F4HDL7_GALAU/1-229               .................................ms-KKTKKEL.FLELAKPDEQGVSRWVSVDEFNGKYSELQ.LG....NGF.....SWGRRSSSLAREYIIETDKTI.TSGNGVDAIRLNGFNKEASF..NQAINVKIKNYYKDQCCVMLGVKGFSENTRIEIDHK..DGRKNDLRVS....D..INS.QHI.DDFQPLCKAANDVKRQICKRCKETNIRWSAKNIK..GNP...FDFYEG.........DEHYTE.........E..LGCKGCYQYDPVQYRKIMIRKVSELAAGQAIDSVFKTLYPD---d...................................
H8AVN4_CAMJU/1-221               ...................................MKVTKMEL.FLEIALPNENGFSRWVDVKEFVNKYKNLQ.LG....NGG.....SWCRTSSALAKKYKIEFDKTK.SNGNSIDRIRLAGFNTQTQF..NQNIRKDIKDFYKNKNCVMLGINGKSENTKIEIDHK..DGRKQDLRVS....N..INL.QKL.EDFQPLCKAANDIKRQICKRCKETNIRWDARNIL..GNP...YNFYKG.........DENYTK.........E..LGCIGCYQYDPVAYRKESIKRISKEVE-----------------efilnkfn............................
E1P4P9_NEILA/1-65                ...................................MKITKTEL.FLRLAKPNEQGISRWVSTSEFAGEYKDLK.LG....NGG.....SWCRKDSPLARDYLLN-----.--------------------..------------------------------------..----------....-..---.---.----------------------------------..---...------.........------.........-..--------------------------------------------siraslp.............................
D0ITQ5_HELP1/1-118               ...................................--------.-----------------------------.--....---.....---------------------.--------------------..------------------MCGVRGNSENTQIEIDHK..DGRKDDLRVS....D..LNT.QTF.DDFQALCKACNDKKRQICKKCKESGYRFDATKIP..GNR...YPFYEG.........AIEYD-.........-..-GCVGCYQYDPIQYRKTCNDRIFNEGYQIGYNQ-----------ktt.................................
G9XDQ5_9FIRM/187-310             ....vyenrsnnhllpdhkfseirwdentkednpd--------.-----------------------------.--....---.....---------------------.--------------------..------------------------------------..-------TMS....D..EEI.R--.TKFQLISNQRNQQKREVCRTCYQTKKRGV---IF..GIP...F-FYEGgldwpegvpEKGKDA.........E..KGCIGCGWYDIEKWRKELVKV-----------------------ldelknege...........................
B6JN48_HELP2/1-127               ..................................m--------.-----------------------------.--....---.....---------------------.--------------------..------------------LCGVRGNSENTQIEVDYK..DGHKDDSRVS....D..LNA.QTF.DDFQALCKACNDKKRQICKKCKENGYRFDARKIP..GNY...YSFYEG.........EAEYD-.........-..-GCVGCYQYDPIQYRKTCNDRIFNEGYQKGYNWGYQIGYHQKTT....................................
Q1CS55_HELPH/2-81                ..................................i--------.-----------------------------.--....---.....---------------------.--------------------..------------------------------------..----------....-..---.---.------------KKRQICKECKETGYRFDATKIP..GNY...YSFYEG.........EAEYD-.........-..-GCVGCYQYDPIQYRKTCNDRIFNEGYQKGYGEGYQIGYHQKTT....................................
Q17YX9_HELAH/1-171               ...................................--------.-----------------------------.--....---.....--------------MEFDKEQ.TPRNSIDRIRLNGYNTKCVF..NQSIRQDIKNHYSQQCCAMCGVWGNSENTQIEVDHK..DGRKNDPRVS....D..LSM.QTL.DDFQALCKACNDKKRQICKECKETGYRFDATKIL..GNH...YPFYEG.........EAEYD-.........-..-GCVGCYQYDPIQYKKTCNDRIYNEGYQKGYDEGYQIGYHQKTT....................................
E4VJ65_9HELI/1-110               .................................vg--------.-----------------VGEFVGAYRTLQ.LG....NGR.....SWCRASSSLAKTYIVELDKSL.TSSSAIDAIRLQGFNPQKAF..NQAIRKDIKDFYKSQKCVMLGVCGKSENTTIEIDHK..DEQQT-----....-..---.---.----------------------------------..---...------.........------.........-..--------------------------------------------rknqqgarc...........................
T2N3_NEILA/1-230                 ...................................MKITKTEL.FLRLAKPNEQGISRWVKTSEFAGEYKDLK.LG....NGG.....SWCRKDSPLARDYIVEFDKGL.TSGNSIDAIRLNGFNQEKHF..KQYIRKDIKDALKTRNCVMLGVNGKSENTKIEIDHK..DGRKNNHRVS....D..IKT.QKL.EDFQPLCKAANDVKRQICKTCKETNKRWSAKNIS..GNP...YAFYMG.........DENYSE.........E..LGCVGCYQYDPVEYRKSSVKRIAAEAAKYTSDYIFKKLYEEDNG....................................
H8H6A9_HELPX/6-104               .........................liqthrllmi--------.-----------------------------.--....---.....---------------------.--------------------..------------------------------------..----------....-..---.---.--FRLYAKLVMIKKRQICKECKETGYRFDATKIP..GNR...YPFYEG.........EAEYD-.........-..-GCVGCYQYDPIQYRKTCNGRIYNEGHQKGYYEGYQNGYHQKTT....................................
Q9L9W6_HELPX/1-231               ...................................MSKSKKEL.FLELAQPDKNGVSRWVSVTEFVGKYQELS.VGgpgsNGR.....TWCRNNSSLAKEFKLEFDKRQ.TLGNSIDRIRLNGYKTKCVF..NQSIRQDIENYYSQQCCAMCGVRGNSENTQIEIDHK..DGRKDDLRVS....D..LNT.QTF.DDFQALCKACNDKKRQICKKCKESGYRFDATKIL..GNR...YPFYEG.........AIEYD-.........-..-GCVGCYQYDPIQYRKTCNDRIFNEGYQKGYYEGYQIGYNQKTT....................................
D7FCC9_HELP3/1-129               ...................................--------.-----------MSRWVSVTEFVGKYQGLQ.LG....NGG.....NWCRNNSSLAKEFNLEFDKGQ.TLGNSIDRIRLNGYNTECVF..NQSIRQDIKNHYKQQCCTMCGAHGNSENTQIEVDHK..DGRKNDSRVS....D..SNA.QTF.DDFQVLCKACND----------------------..---...------.........------.........-..--------------------------------------------....................................
H8H6B0_HELPX/1-47                ...................................--------.-----------------------------.--....---.....---------------------.--------------------..------------------MCGAHGNSENTQIEVDHK..DGRKDDSRVS....D..SNA.QTF.DDFQALCKACND----------------------..---...------.........------.........-..--------------------------------------------....................................
Q7VHB6_HELHP/1-224               ...................................MRKSKIEI.FLELAKPDKNGISRWVSVSEFIGEYKALA.LG....NGG.....SWCRASSTLAKKYILEFDKSK.SAGNAIDAIRLKGFNTQKTF..NQAIRKDIKDFYKNQNCVMLGICGKSENTKIEIDHK..DGRKNDLRIS....N..QQT.QKL.EDFQPLCKAANDVKRQICKVCRETNKRWSAKNIK..GNP...YAFYQG.........DENYTQ.........E..LGCVGCYQYDPVAYRKESARKIAKEAADFITQKLYKK-------e...................................
B9XZR6_HELPX/1-129               ...................................--------.-----------MSRWVSVTEFVGKYQGLQ.LG....NGG.....NWCRNNSSLAKEFNLEFDKGQ.TLGNSIDRIRLNGYNTECVF..NQSIRQDIKNHYKQQCCTMCGAHGNSENTQIEVDHK..DGRKNDSRVS....D..SNA.QTF.DDFQVLCKACND----------------------..---...------.........------.........-..--------------------------------------------....................................
Q9L9W9_HELPX/1-177               ...................................--------.-----------------------------.--....---.....--------MAKEFELEFDKRQ.TPGNSIDRIRLNGYNTRCVF..NQSIRQDIKNYYSQQCCAMCGVHGNSENTQIEIDHK..DGRKDDPRVS....D..LNT.QTF.DDFQALCKACNDKKRQICKKCKESGYRFDATKIP..GNP...YPFYEG.........EFEYD-.........-..-GCVGCYQYDPIQYRKTCNDRIFNEGYQKGYDEGYQIGYNQKTT....................................
Q9L677_HELPX/1-227               ...................................MSKSKKEL.FLELAQPDKNGVSRWVSVIEFIREYQGLQ.LG....NGG.....SWCRNSSSLAKEFILEFDREQ.APGNSIDRIRLNGYKTRGVF..NQSIRQNIKNYYKQQCCAMCGVRGNSENTQIEVDHK..DDRKNDLRVS....D..LNT.QDF.DDFQALCKACNDKKRQICKKCKESGYRFDATKIP..GNH...YPFYEG.........VAEYD-.........-..-GCVGCYQYDPIQYRKTCNDRIFNEGYQKGYGEGYQIGYNQKTT....................................
E6NLK6_HELPL/1-227               ...................................MSKSKKEL.FLELAQPDKNGMSRWVSAIEFIGKYQGLQ.LG....NGG.....SWCRNNSSLAKEFKLEFDKRQ.TLGNSIDRIRLNGYNTRCVF..NQSIRQDIKNYYSQQCCAMCDVRGNSENTQIEIDHK..DGRKDDLRVS....D..LNT.QTF.DDFQALCKACNDKKRQICKKCKESGYRFDATKIP..GNY...YPFYEG.........EAEYD-.........-..-GCVGCYQYDPIQYRKTCNNRIFNEGYQKGYDEGYQIGYHQKTT....................................
E1Q3E4_HELPP/1-126               ...................................--------.-----------------------------.--....---.....---------------------.--------------------..------------------MCGVRGNSENTQIEVDHK..DGRKDDLRVS....D..LNT.QTF.DDFQALCKACNDKKRQICKKCKESGYRFDATKIP..GNR...YPFYDG.........AFEYD-.........-..-GCVGCYQYDPIQYRKICNDGIFNEGYQKGYNEGYQIGYHQKTT....................................
A7NKK7_ROSCS/77-220              trnsfvrlqipqklrsriisyyknieaitlrqltp--------.-----------------------------.--....---.....---------------------.--------------------..----------------------------EKLEIDHRfpQVRWSQNENF....DpnMPEdEIH.RRFQPLTRENNLWKSRYCEKCKKTGERGTFIGINffAEG...GHQWDA.........GIPEDD.........E..RGCYGCFWYNPDAWREALNNFIA---------------------rshg................................
C6S5V1_NEIML/170-308             .............ngyetwskelrkrilavlnnid--------.-----------------------------.--....---.....---------------------.--------------------..---------------------VYENKFNTHVLPDHKfsEIRWDDNTKSqnpdD..MTD.DEIkQKFQLLSNQRNQQKREVCRTCFQTGKRG---VIF..GIP...F-WYKG.........TADWDKsiptkgknaE..QGCIGCAWYDIEAWRNELVKRL----------------------k...................................
H8CPY8_CAMJU/1-221               ...................................MKVTKMEL.FLEIALPNENGFSRWVDVKEFVNKYKNLQ.LG....NGG.....SWCRTSSALAKKYKIEFDKTR.SNGNSIDRIRLAGFNTQTQF..NQNIRKDIKDFYKNKNCVMLGINGKSENTKIEIDHK..DGRKQDLRVS....N..INL.QKL.EDFQPLCKAANDIKRQICKRCKETNIKWDARNIL..GNP...YNFYKG.........DENYTK.........E..LGCIGCYQYDPVAYRKESIKRISKEVE-----------------efilnkfn............................
Q8VTH1_HELPX/1-227               ...................................MSKSKKEL.FLELAQSDKNGVSRWVSVTEFVGKYQGLQ.LG....NGG.....SWCRNNSSLAKEFNLEFDKGQ.TPGNSIDRIRLNGYNTECVF..NQSIRQDIKNYYKQQCCAMCGVRGNSENTQIEVDHK..DGRKDDSRVS....D..SNA.QTF.DDFQALCKACNDKKRQICKKCKESGYRFDATKIH..GNR...YPFYEG.........EAEYD-.........-..-GCLGCYQYDPIQYRKTCNGRIYNEGHQKGYYEGYQNGYHQKTT....................................
E6NHM8_HELPK/1-231               ...................................MSKSKKEL.FLELAQPDKNGVSRWVSVTEFVGKYQELS.VGgpgsNGR.....TWCRNSSSLAKEFELEFDYRK.AQGNPIDRIRLNGYNTKRVF..NQNICQDIKNHYKQQCCAMCGARGNSENTQIEVDHK..DGRKDDLRVS....D..LNT.QTL.NDFQALCKACNDKKRQICKKCKESGYRFDATKIP..GNP...YPFYEG.........EFEYD-.........-..-GCVGCYQYDPIQYRKTCNDRIFNEGYQKGYYNGYQIGYNQKTT....................................
E8QTJ7_HELPW/1-227               ...................................MNKSKKEL.FLELAQPDNNGVSRWVSVTEFVGKYQELQ.LG....NGG.....SWCRKNSSIAKEFNLEFDKEQ.TLGNSIDRIRLNGYNTECVF..NQSIRQDIKNHYSQQCCAMCGVRGNSENTKIEVDHK..DGHKDDPRVS....D..LSM.QTF.DDFQALCKACNDKKCQICKECKETGYRFDARKIP..GNH...YPFYER.........EAEYD-.........-..-GCVGCYQYDSIQYRKICNDRIYNEGYQKGYDDGYQIGYYQKTT....................................
F4D2J1_HELPX/2-159               ..............................ikgkl--------.-----------------------------.--....---.....---------------------.---NSIDRIRLNGYNTRCVF..NQSIRQDIKNYYSQQCCAMCGVRGNSENTQIEIDHK..DGRKDDPKVS....D..LNT.QTF.DDFQALCKACNDKKRQICKKCKESGYRFDATKIP..GNR...YPFYEG.........AFEYD-.........-..-GCVGCYQYDPIQYRKTCNDRIFNEGYQIGYNQ-----------ktt.................................
E1Q3E5_HELPP/1-88                ...................................MSKSKKEL.FLELAQPDKNGMSRWVSAIEFIG--QGLK.LS....NGG.....SWCRSNSSLAKEFELEFDRMQ.TLGNSIDRIRLNGYKTKCVF..NQSIR-------------------------------..----------....-..---.---.----------------------------------..---...------.........------.........-..--------------------------------------------sr..................................
E4ZAF0_NEIL0/1-230               ...................................MKITKTEL.FLRLAKPNEQGISRWVSTSEFAGEYKDLK.LG....NGG.....SWCRKDSPLARDYIVEFDKGL.TSGNSIDAIRLNGFNQEKHF..KQYIRKDIKDALKTRNCVMLGVNGKSENTKIEIDHK..DGRKNNHRVS....D..IKT.QKL.EDFQPLCKAANDVKRQICKACKETNKRWSAKNIS..GNP...YAFYMG.........DENYSE.........E..LGCVGCYQYDPVEYRKSSVKRIAAEAAKYTSDYIFKKLYEEDNG....................................
D0ITQ6_HELP1/1-97                ...................................MSKSKKEL.FLELAQPDKNGVSRWVSATEFIGKYQGLQ.LG....NGG.....SWCRNNSSLAKEFELEFDKRQ.TPGNSIDRIRLNGYKTKCVF..NQSIRQDIKNYYSQ----------------------..----------....-..---.---.----------------------------------..---...------.........------.........-..--------------------------------------------....................................
D0K0S6_HELP5/2-167               ..............................ikgkl--------.-----------------------------.--....---.....---------------------.---NSIDRIRLNGYNTRCVF..NQSVRQDIKNYYSQQCCAMCGVRGNSENTQIEIDHK..DGRKDDLRVS....D..LNT.QTF.DDFQALCKACNDKKRQICKKCKESGYRFDATKIP..GNR...YPFYEG.........AIEYD-.........-..-GCVGCYQYDPIQYRKTCNDRIFDEGYQKGYYEGYQIGYNQKTT....................................
G2MAL8_HELPX/1-227               ...................................MSKSKKEL.FLELAQPDKNGVSRWVSAIEFIGKYQGLQ.LG....NGG.....SWCRSNSSLAKEFELEFDKEQ.TPGNSIDRIRLNGYKTKCVF..NQSIRQDIKNYYSQQCCAMCGARGNSENTQIEVDHK..DGRKDDLRVS....D..LNT.QTF.DDFQALCKACNDKKRQICKKCKESGYRFDAQKIP..GNR...YPFYEG.........AIEYD-.........-..-GCVGCYQYDPIQYRKICNDGIFNEGYQKGYDEGYQIGYNQKTT....................................
A3ZFH3_CAMJU/1-131               ...................................MKVTKMEL.FLEIALPNENGFSRWVDVKEFVNKYKNLQ.LG....NGG.....SWCRTSSALAKKYKIEFDKTK.SNGNSIDRIRLAGFNTQTQF..NQNIRKDIKDFYKNKNCVMLGINGKSENTKIEIDHK..DGRKQDLRVS....N..I--.---.----------------------------------..---...------.........------.........-..--------------------------------------------....................................
D7FCD0_HELP3/6-96                .........................liqthrllmi--------.-----------------------------.--....---.....---------------------.--------------------..------------------------------------..----------....-..---.---.--FRFYAKLVMIKKRQICKECKETGYRFDATKIP..GNH...YPFYEG.........EAEYD-.........-..-GCVGCYQYDPIQYRKTCNDGIYNEGYQNGYHQ-----------ktt.................................
O25810_HELPY/1-171               ...................................--------.-----------------------------.--....---.....--------------MEFDKGQ.TLGNFIDRIRLNGYNTECVF..NQSICQDIKNHYKQQCCAMCGVRGNSENTQIEVDHK..DGRKDDSRVS....D..LST.QAF.DDFQALCKACNDKKRQICKKCKETGYRFDARKIP..GNH...YSFYEG.........EAEYD-.........-..-GCVGCYQYDPIQYRKTCNDRIYNEGYQKGYSDGYQIGYHQKTT....................................
E6NSX9_HELPQ/1-119               ..................................m--------.-----------------------------.--....---.....---------------------.--------------------..------------------LCGARGNSENTQIEIDHK..DGRKDDLRVS....D..LNT.QTF.DDFQALCKACNDKKRQICKKCKESGYRFDATKIP..GNR...YPFYEG.........AIEYD-.........-..-GCVGCYQYDPIQYRKTCNDRIFNEGYQIGYNQ-----------ktt.................................
Q9L9W5_HELPX/1-227               ...................................MSKSKKEL.FLELVQPDKNGVSRWVSAIEFIGKYQGLQ.LG....NGG.....SWCRNNSSLAKEFKLEFDKRQ.TPGNSIDRIRLNGYNTRCVF..NQSIRQDIKNYYSQQCCAMCGVHGNSENTQIEIDHK..DGRKDDLRVS....D..LNT.QTF.DDFQALCKACNDKKRQICKKCKESGYRFDATKIP..GNP...YPFYEG.........EFEYD-.........-..-GCVGCYQYDPIQYRKTCNDRIFNEGYQKGYDEGYQIGYNQKTT....................................
H7YW12_CAMJU/1-221               ...................................MKVTKMEL.FLEIALPNENGFSRWVDVKEFVNKYKNLQ.LG....NGG.....SWCRTSSALAKKYKIEFDKTK.SNGNSIDRIRLAGFNTQTQF..NQNIRKDIKDFYKNKNCVMLGINGKSENTKIEIDHK..DGRKQDLRVS....N..INL.QKL.EDFQPLCKAANDIKRQICKRCKETNIRWDARNIL..GNP...YNFYKG.........DENYTK.........E..LGCIGCYQYDPVAYRKESIKRISKEVE-----------------efilnkfn............................
Q9L9W8_HELPX/1-171               ...................................--------.-----------------------------.--....---.....--------------MEFDKGR.TLGNSIDRIRLNGYNVKCVF..NQSIRQDIKNHYSQQCCTMCGARGNSENTQIEVDHK..DGRKDDPRVS....D..LNT.QTF.DDFQALCKACNDKKRQICKECKETGYGFDARKIL..GNH...YSFYEG.........EAEYD-.........-..-GCVGCYQYDPIQYRKTCNDRIYNEGYQKGYYEGYQNGYHQKTT....................................
G1VMJ4_9FIRM/4-103               ..............................efyrd--------.----------KIERCIADIEDETELKQIY.TY....AHT.....KWCRSKSSLNKYFALESVKKQ.ISAMSIAQYRRNIH------..------------------------------------..----------....-..---.---.----------------------------------..---...------.........------.........-..--------------------------------------------eciysihekdgldrifnlamrikqaqseksefsvkd
B9XZR5_HELPX/6-96                .........................liqthrllmi--------.-----------------------------.--....---.....---------------------.--------------------..------------------------------------..----------....-..---.---.--FRFYAKLVMIKKRQICKECKETGYRFDATKIP..GNH...YPFYEG.........EAEYD-.........-..-GCVGCYQYDPIQYRKTCNDGIYNEGYQNGYHQ-----------ktt.................................
Q9L9W3_HELPX/1-227               ...................................MSKSKKEL.FLELAQPDKNGVSRWVSAIEFIGKYQGLQ.LG....NGG.....SWCRNNSSLAKEFKLEFDKRQ.TPGNSIDRIRLNGYNTRCVF..NQSIHQDIKNYYSQQCCAMCGVRGNSENTQIEIDHK..DGRKDDLRVS....D..LNT.QTF.DDFQALCKACNDKKRQICKKCKESGYRFDATKIP..GNP...YPFYEG.........EFEYD-.........-..-GCVGCYQYDPIQYRKTCNDRIFNEGYQKGYYEGYQIGYNQKTT....................................
B2CW66_HELPX/1-53                ...................................--------.-----------------------------.--....---.....---------------------.--------------------..------------------MCGARGNSENTQIEVDHK..DGRKDDLRVS....D..LNT.QTF.DDFQALCKACNDKKRQIC----------------..---...------.........------.........-..--------------------------------------------....................................
E1Q0T2_HELPM/1-227               ...................................MSKSKKEL.FLELAQPDKNGVSRWVSAIEFIGKYQGLQ.LG....NGG.....SWCRSNSSLAKEFELDFDKMQ.TLGNSIDRIRLNGYKTKCVF..NQSIRQDIKNHYKQQCCAMCGARGNSENTQIEVDHK..DGRKDVLRVS....D..LNT.QTF.DDFQALCKACNDKKRQICKKCKEIGYRFDATKIL..GNR...YPFYEG.........AFEYD-.........-..-GCVGCYQYDPIQYRKTCNDRIFNEGYQKGYYEGYQIGYNQKTT....................................
Q8VTH0_HELPX/1-227               ...................................MSKSKKEL.FLELAQPDKNGVSRWVSVREFVGKYQGLQ.LG....NGG.....SWCRNSSALAKEFNLEFDKGQ.TLGNSIDRIRLNGYNTECVF..NQSIRQDIKNHYKQQCCTMCGTRGNSENTQIEVDHK..DGRKNDSRVS....D..SNA.QTF.DDFQALCKACNDKKRQICKECKETGYRFDATKIL..GNH...YSFYEG.........EAEYD-.........-..-GCVGCYQYDPIQYKKTCNDRIYNEGYQKGYYEGYQNGYHQKTT....................................
Q8VQ95_HELPX/1-227               ...................................MSKSKKEL.FLELAQPNKNGMSRWVSAIEFVGKYQGLQ.LG....NGG.....SWXRNNSSXAKEFXLEFDKGQ.TPGNSIDRIRLNGYNTRCVF..NQSIRQDIKNYYSQQCCXMCGAHGNSENAQIEIDHK..DGRKDDLRVS....D..SNT.QTF.DDFQALCKACNDKKRQICKKCKESGYRFDATKIP..GNY...YSFYEG.........EAEYD-.........-..-GCVGCYQYDPIQYRKTCNDRIYNEGYQKGYGEGYQIGYHQKTT....................................
E6LAP4_CAMUP/1-132               ..................................m--KSKMDL.FLELAKPDEKGFSRWVGVDEFVGDYKDLQ.FG....NGG.....SWCRASSNLAKTYIIEFDKTR.TSGNSIDAIRLQGFNPLKTF..NQNIRKDIKDFYKSQKCVMLGVCGKSENTTIEIDHK..DGQQT-----....-..---.---.----------------------------------..---...------.........------.........-..--------------------------------------------rknqqgary...........................
H8H6C6_HELPX/1-56                ...................................MNKSKKEL.FLELAQPDKNGVSRWVSVTEFVEKYQGLQ.LG....NGG.....SWCRNNSSLVRN---------.--------------------..------------------------------------..----------....-..---.---.----------------------------------..---...------.........------.........-..--------------------------------------------ly..................................
Q9L9W7_HELPX/1-227               ...................................MNKSKKEL.FLELAQPDKNGVSRWVSAIEFIGKYQGLQ.LG....NGG.....SWCRNNSSLAKEFELEFDKRQ.TLGNSIDRIRLNGYKTKCVF..NQSIRQDIENYYSQQCCAMCGVRGNSENTQIEIDHK..DGRKDDLRVS....D..LNT.QTF.DDFQALCKACNDKKRQICKKCKESGYRFDATKIL..GNR...YPFYEG.........AIEYD-.........-..-GCVGCYQYDPIQYRKTCNDRIFNEGYQKGYYEGYQIGYNQKTT....................................
I0E5U1_HELPX/1-227               ...................................MSKSKKEL.FLELAQPDKNGMSRWVSAIEFIGKYQGLQ.LG....NGG.....SWCRSNSSLAKEFELEFDKEQ.TLGNSIDRIRLNGYKTKCVF..NQSIRQDIKNYYSQQCCAMCGAHGNSENTQIEIDHK..DGRKDDLRVS....D..LNT.QTF.DDFQALCKACNNKKRQICKKCKESGYRFDATKIP..GNY...YPFYEG.........EFEYD-.........-..-GCVGCYQYDPIQYRKTCNDRIFYEGCQKGYDEGYQIGYNQKTT....................................
#=GC seq_cons                    .......................................................hpRWlts.EF.sthptLt.hu....Nst.....sWhRtsSshA+ca.lEFDKtp.o.GNSID+IRLNGapscpsF..NQsIRpDIKsaYpppsCsMpGspGpSENTpIElDHK..DGRKsD.RVS....D..hss.Qph.-DFQsLCKAsNDpKRQICKcCKEoGhRasAppI...GN....YsFY-G.........t.pYD..............GCVGCYQYDPlpYRKpsscRIhpEuhphs..................................................
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