GenomeNet

Database: Pfam
Entry: ICEA
LinkDB: ICEA
Original site: ICEA 
#=GF ID   ICEA
#=GF AC   PF05315.10
#=GF DE   ICEA Protein
#=GF AU   Moxon SJ
#=GF SE   Pfam-B_2792 (release 7.7)
#=GF GA   24.00 24.00;
#=GF TC   26.00 24.70;
#=GF NC   22.40 21.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11843964
#=GF RT   Distribution of distinct vacA, cagA and iceA alleles in
#=GF RT   Helicobacter pylori in Hong Kong. 
#=GF RA   Wong BC, Yin Y, Berg DE, Xia HH, Zhang JZ, Wang WH, Wong WM,
#=GF RA   Huang XR, Tang VS, Lam SK; 
#=GF RL   Helicobacter 2001;6:317-324.
#=GF DR   INTERPRO; IPR007979;
#=GF CC   This family consists of several ICEA proteins from Helicobacter
#=GF CC   pylori. Helicobacter pylori infection causes gastritis and
#=GF CC   peptic ulcer disease, and is classified as a definite carcinogen
#=GF CC   of gastric cancer. ICEA1 is  speculated to be associated with
#=GF CC   peptic ulcer disease [1].
#=GF SQ   15
#=GS F4HDL7_GALAU/5-226        AC F4HDL7.1
#=GS A0A0G0I9M7_9BACT/2-223    AC A0A0G0I9M7.1
#=GS R7K098_9CLOT/6-204        AC R7K098.1
#=GS R6MU15_9FIRM/8-207        AC R6MU15.1
#=GS R5DUR5_9FIRM/6-202        AC R5DUR5.1
#=GS S6F2C9_AVIPA/1-200        AC S6F2C9.1
#=GS H5VFN0_HELBI/1-216        AC H5VFN0.1
#=GS J9R1X7_RIEAN/2-219        AC J9R1X7.1
#=GS I7H4A2_9HELI/1-99         AC I7H4A2.1
#=GS F2NRE4_TRES6/83-300       AC F2NRE4.1
#=GS O25810_HELPY/1-158        AC O25810.1
#=GS V8CK27_9HELI/5-134        AC V8CK27.1
#=GS A0A0C2Z7Z5_9PROT/198-305  AC A0A0C2Z7Z5.1
#=GS Q7VHB6_HELHP/4-221        AC Q7VHB6.1
#=GS R5LIV2_9SPIR/1-120        AC R5LIV2.1
F4HDL7_GALAU/5-226                   ......................................................................................................................TKKELFLELAKPDEQGVSRWVSVDEFNGKYSELQLGNGFSWGRRSSSLAREYIIETDKTITSGNGVDAIRLNGFNKEASF..NQAINVKIKNYYKDQCCVMLGVKGFSENTRIEIDHKDGRKNDLRVSDINSQHIDDFQPLCKAANDVKRQICKRCKETNIRWSAKNIKGNPFDFYEGD.E.HY.........TE.EL.........GCKGCYQYDPVQYRKIMIRKVSElaagQAIDSVFKTLY..........
A0A0G0I9M7_9BACT/2-223               ......................................................................................................................TKKELFLELAMPNQQGISRWVSVSEFIGKYKELQLGNGGSWCRASSNLAKEYQIEADKSITSGNSIDRIRLIGLNTKKHF..NQNIRKDIKDFYKTQNCVMLGVNGNSENTKIEIDHKDGRKNDHRISNPQNQLLSDFQPLSKCANDVKRQICKKCRETNKRWSAKNIKGNPYDFYIGD.E.NY.........SE.EL.........GCRGCYQYDPVEYRKVIVKNISElsakEAVDSVFKKLY..........
R7K098_9CLOT/6-204                   ......................................................................................................................TKVELFEELAEIDENGCSRWVSVKEFVGRYAELQLFNGAGWSRDDGPFGKKYQVERDRSRTPGNRVDALRTVGFAIDSAR..TAYIDPEIKCIIKSKRCVVLGTS------NPEVDHKNGMKNEKRVMQNIDQRLSDFQPLSKAANDAKRQFCKECRASGKRFDATKL-GYPMSFYQGGpY.HH.........NE.ED.........ACVGCYWYDPLEFKRHL------....-----------qekk......
R6MU15_9FIRM/8-207                   .....................................................................................................................t-KPFLFEKLASPDENGVSRWVSKSEFVGKYADLMFQNGASWCRKESSIAKKYIVEFDKSQTPGNGVDRIRLNGFRKEDDWigGQSIRSDIKNYYKQKRCVILGTS------NPEVDHKNGWKNDSNAMNTATQKLGDFQPLSKAANDAKRQFCKECRRTGKRYDAKKL-GYPVSFYYGD.E.NH.........NEsED.........GCIGCFWYDPIEFRKHL------....-----------sfk.......
R5DUR5_9FIRM/6-202                   ......................................................................................................................TKIELFEELAGIDENGFSRWVSVDEFVGEYQGLQLLNGAGWSRDDGPFGRKYIVERDKTRTPGNRTDAIRTVGFNNG-DY..SQHIRADIKRQIQSQRCVILGTS------NPEVDHKNGMKNEDRVMRNEDQKLSDFQPLSKAANDAKRQFCKECIRTGIRYDAKKL-GYPMSYYKGD.ArHN.........GE.EN.........ACEGCFWYDPLEFRKHL------....-----------kek.......
S6F2C9_AVIPA/1-200                   .....................................................................................................................m-----------------------SEFIGDYLELQLGNGFSWGRGSSSLAKEYIVETDKTHSSGNGIDAIRLNGFNRKNYF..NQAIRQDIKNYYKDKPCVMLGVKGFSENTKIEIDHKDGRKNDLRVSDMNSQSLNDFQPLCKAANDVKRQICKRCKETNIRWSAKNIKGNPYDFYEGN.E.NY.........ND.EL.........GCVGCYQYDPVQYRKTVIKKVSElaahRAVDVVFKTLY..........
H5VFN0_HELBI/1-216                   .....................................................................................................................m---DLFLELAQPNTDGFSRWVSVSEFSGKYQELQLGNGGSWLRPSSSLAKKYKIEVDKSQSSGNSIDRIRLVGFNTEIVF..NQNIRQDIKDFYKNQRCVMLGVCGKSENTKIEIDHKDGRKNDLRVADVSSQRLEDFQSLCKAANDIKRQICKTCKETNLRWNAKNIAGNPYAFYAGD.E.HH.........TD.EL.........GCVGCYQYDPVAYCQECVKKIAK....EASEYIYHKIY..........
J9R1X7_RIEAN/2-219                   ......................................................................................................................TKTELFLELAKPDSNGVSRWVSVNEFIGKYKALQLGNGGSWCRASSSLAKTYTIEFDKTKTRGNSIDAIRLTGFNNSNTF..NQSIRKEIKDFYKNKNCVMLGINGNSINTKIEIDHKDGRKDNDRVSNIKTQRLEDFQPLSKAANDAKRQICKRCKETNLRWNAKNLKGNPYSFYEGD.E.HY.........TQ.EL.........GCVGCYQFDPVEYRKSSVIKISK....EVTDNILKKLY..........
I7H4A2_9HELI/1-99                    ......................................................................................................................--------------------------------MQLGNGRSWCRASSSLAKTYIVELDKSLTSSSAIDAIRLQGFNPQKAF..NQAIRKDIKDFYKSQKCVMLGVCGKSENTTIEIDHKDEQQT--------------------------------------------------------.-.--.........--.--.........-----------------------....-----------rknqqgarcg
F2NRE4_TRES6/83-300                  kakpkadttksffdkltedfeykcvncqlpnnpnwarriqdlkefgytiatklseycphcnkntthlimlpikrggitgyetwsselrtrivsllksydvfeakttkkegllpdhkfs--------------------------------------------------------------------------------..-------------------------------EIRWNDETKRETLENLTDKEILRDFQLLSNQRNQQKREICRNCYQTGKRG---TIYGIPF-FYEGT.E.NWdssipkngkSA.EK.........GCIGCAWYDIERWRQELIKKL--....-----------k.........
O25810_HELPY/1-158                   ......................................................................................................................-----------------------------------------------------MEFDKGQTLGNFIDRIRLNGYNTECVF..NQSICQDIKNHYKQQCCAMCGVRGNSENTQIEVDHKDGRKDDSRVSDLSTQAFDDFQALCKACNDKKRQICKKCKETGYRFDARKIPGNHYSFYEGE.A.EY.........D-.--.........GCVGCYQYDPIQYRKTCNDRIYN....E----------gyqkgy....
V8CK27_9HELI/5-134                   ......................................................................................................................TKIDLFLELAKPDEMGFSRWVGVGEFVGACRTLQLGNGGSWCKASSTLAKKHIIEFDKSRTSGNAIDAIRLQGFNPHQSF..NQAIRKDIKDFYKSQKCVMLGVCGKSENTHIEIDHKDGQQT--------------------------------------------------------.-.--.........--.--.........-----------------------....-----------rknqqgary.
A0A0C2Z7Z5_9PROT/198-305             ...........................................................................................dhkfpeirwdsltkesnenltddeigi--------------------------------------------------------------------------------..------------------------------------------------------KFQLLDNQRNLQKREVCRKCFQTNKRGI---IFGINY-FYEGD.E.NW.........SD.EIpkigkeaesGCIGCAWYDIEAWRDSL------....-----------nkillikke.
Q7VHB6_HELHP/4-221                   ......................................................................................................................SKIEIFLELAKPDKNGISRWVSVSEFIGEYKALALGNGGSWCRASSTLAKKYILEFDKSKSAGNAIDAIRLKGFNTQKTF..NQAIRKDIKDFYKNQNCVMLGICGKSENTKIEIDHKDGRKNDLRISNQQTQKLEDFQPLCKAANDVKRQICKVCRETNKRWSAKNIKGNPYAFYQGD.E.NY.........TQ.EL.........GCVGCYQYDPVAYRKESARKIAK....EAADFITQKLY..........
R5LIV2_9SPIR/1-120                   ......................................................................................................................--------------------------------------------------------------------------------..------------------MLGVCGKSENTKIEIDHKDGRKNDYRVSDLKSQNINDFQPLCKAANDIKRQICKNCKKTNKRWNARNIRGNPYSFYAGD.E.NY.........TQ.EL.........GCVGCYQYDPVAYRKESVKKIAK....EAADYIASKLY..........
#=GC seq_cons                        ..........................................................................................................................lF.cLA..sp.GhSRWVuhsEF.GcYttLQLtNGtSWsRssSslAKcYhlEhDKopTsGNulDtIRL.GFNpppsF..NQsIRpDIKsaYKsppCVMLGlsG.SENTpIEIDHKDGpKN-.Rlss.psQpLpDFQPLsKAANDhKRQICKcC+cTshRasA+pIhG.PasFYpGD.E.pa.........sp.Eh.........GClGCY.YDPlpaRKph..pl...........................
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