GenomeNet

Database: Pfam
Entry: ICEA
LinkDB: ICEA
Original site: ICEA 
#=GF ID   ICEA
#=GF AC   PF05315.9
#=GF DE   ICEA Protein
#=GF AU   Moxon SJ
#=GF SE   Pfam-B_2792 (release 7.7)
#=GF GA   24.00 24.00;
#=GF TC   26.50 34.70;
#=GF NC   22.40 21.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11843964
#=GF RT   Distribution of distinct vacA, cagA and iceA alleles in
#=GF RT   Helicobacter pylori in Hong Kong. 
#=GF RA   Wong BC, Yin Y, Berg DE, Xia HH, Zhang JZ, Wang WH, Wong WM,
#=GF RA   Huang XR, Tang VS, Lam SK; 
#=GF RL   Helicobacter 2001;6:317-324.
#=GF DR   INTERPRO; IPR007979;
#=GF CC   This family consists of several ICEA proteins from Helicobacter
#=GF CC   pylori. Helicobacter pylori infection causes gastritis and
#=GF CC   peptic ulcer disease, and is classified as a definite carcinogen
#=GF CC   of gastric cancer. ICEA1 is  speculated to be associated with
#=GF CC   peptic ulcer disease [1].
#=GF SQ   14
#=GS K2G8J7_9BACT/6-207      AC K2G8J7.1
#=GS F4HDL7_GALAU/5-226      AC F4HDL7.1
#=GS A0A0G0I9M7_9BACT/2-223  AC A0A0G0I9M7.1
#=GS R7K098_9CLOT/6-204      AC R7K098.1
#=GS R6MU15_9FIRM/8-207      AC R6MU15.1
#=GS R5DUR5_9FIRM/6-202      AC R5DUR5.1
#=GS H5VFN0_HELBI/1-216      AC H5VFN0.1
#=GS J9R1X7_RIEAN/2-219      AC J9R1X7.1
#=GS I7H4A2_9HELI/1-99       AC I7H4A2.1
#=GS F2NRE4_TRES6/83-300     AC F2NRE4.1
#=GS K4RMW4_HELHE/1-188      AC K4RMW4.1
#=GS O25810_HELPY/1-158      AC O25810.1
#=GS Q7VHB6_HELHP/4-221      AC Q7VHB6.1
#=GS R5LIV2_9SPIR/1-120      AC R5LIV2.1
K2G8J7_9BACT/6-207                 ......................................................................................................................SKLDLFVEFAKPDENWVSKWINKTDFKWDYASLYFDNWFPWWRWSAKIKFKYILEVRKDITPWNRIDAIRLNWFNTKINL..NQWIRKDIIDEITNKRCIVLGTH-..TSWDYKTAPDHKDWRKNNLETMNTKTQKIEDFQPLSKPANDAKRQFCKECKKSWQRYDATKLW-YPVSVVKWD.L.QY.........DE.KLWCKGCFWYDPIEFRKN-------....-----------lkfs......
F4HDL7_GALAU/5-226                 ......................................................................................................................TKKELFLELAKPDEQGVSRWVSVDEFNGKYSELQLGNGFSWGRRSSSLAREYIIETDKTITSGNGVDAIRLNGFNKEASF..NQAINVKIKNYYKDQCCVMLGVKG..FSENTRIEIDHKDGRKNDLRVSDINSQHIDDFQPLCKAANDVKRQICKRCKETNIRWSAKNIKGNPFDFYEGD.E.HY.........TE.ELGCKGCYQYDPVQYRKIMIRKVSElaagQAIDSVFKTLY..........
A0A0G0I9M7_9BACT/2-223             ......................................................................................................................TKKELFLELAMPNQQGISRWVSVSEFIGKYKELQLGNGGSWCRASSNLAKEYQIEADKSITSGNSIDRIRLIGLNTKKHF..NQNIRKDIKDFYKTQNCVMLGVNG..NSENTKIEIDHKDGRKNDHRISNPQNQLLSDFQPLSKCANDVKRQICKKCRETNKRWSAKNIKGNPYDFYIGD.E.NY.........SE.ELGCRGCYQYDPVEYRKVIVKNISElsakEAVDSVFKKLY..........
R7K098_9CLOT/6-204                 ......................................................................................................................TKVELFEELAEIDENGCSRWVSVKEFVGRYAELQLFNGAGWSRDDGPFGKKYQVERDRSRTPGNRVDALRTVGFAIDSAR..TAYIDPEIKCIIKSKRCVVLGTS-..-----NPEVDHKNGMKNEKRVMQNIDQRLSDFQPLSKAANDAKRQFCKECRASGKRFDATKL-GYPMSFYQGGpY.HH.........NE.EDACVGCYWYDPLEFKRHL------....-----------qekk......
R6MU15_9FIRM/8-207                 .....................................................................................................................t-KPFLFEKLASPDENGVSRWVSKSEFVGKYADLMFQNGASWCRKESSIAKKYIVEFDKSQTPGNGVDRIRLNGFRKEDDWigGQSIRSDIKNYYKQKRCVILGTS-..-----NPEVDHKNGWKNDSNAMNTATQKLGDFQPLSKAANDAKRQFCKECRRTGKRYDAKKL-GYPVSFYYGD.E.NH.........NEsEDGCIGCFWYDPIEFRKHL------....-----------sfk.......
R5DUR5_9FIRM/6-202                 ......................................................................................................................TKIELFEELAGIDENGFSRWVSVDEFVGEYQGLQLLNGAGWSRDDGPFGRKYIVERDKTRTPGNRTDAIRTVGFNNG-DY..SQHIRADIKRQIQSQRCVILGTS-..-----NPEVDHKNGMKNEDRVMRNEDQKLSDFQPLSKAANDAKRQFCKECIRTGIRYDAKKL-GYPMSYYKGD.ArHN.........GE.ENACEGCFWYDPLEFRKHL------....-----------kek.......
H5VFN0_HELBI/1-216                 .....................................................................................................................m---DLFLELAQPNTDGFSRWVSVSEFSGKYQELQLGNGGSWLRPSSSLAKKYKIEVDKSQSSGNSIDRIRLVGFNTEIVF..NQNIRQDIKDFYKNQRCVMLGVCG..KSENTKIEIDHKDGRKNDLRVADVSSQRLEDFQSLCKAANDIKRQICKTCKETNLRWNAKNIAGNPYAFYAGD.E.HH.........TD.ELGCVGCYQYDPVAYCQECVKKIAK....EASEYIYHKIY..........
J9R1X7_RIEAN/2-219                 ......................................................................................................................TKTELFLELAKPDSNGVSRWVSVNEFIGKYKALQLGNGGSWCRASSSLAKTYTIEFDKTKTRGNSIDAIRLTGFNNSNTF..NQSIRKEIKDFYKNKNCVMLGING..NSINTKIEIDHKDGRKDNDRVSNIKTQRLEDFQPLSKAANDAKRQICKRCKETNLRWNAKNLKGNPYSFYEGD.E.HY.........TQ.ELGCVGCYQFDPVEYRKSSVIKISK....EVTDNILKKLY..........
I7H4A2_9HELI/1-99                  ......................................................................................................................--------------------------------MQLGNGRSWCRASSSLAKTYIVELDKSLTSSSAIDAIRLQGFNPQKAF..NQAIRKDIKDFYKSQKCVMLGVCG..KSENTTIEIDHKDEQQT--------------------------------------------------------.-.--.........--.-------------------------....-----------rknqqgarcg
F2NRE4_TRES6/83-300                kakpkadttksffdkltedfeykcvncqlpnnpnwarriqdlkefgytiatklseycphcnkntthlimlpikrggitgyetwsselrtrivsllksydvfeakttkkegllpdhkfs--------------------------------------------------------------------------------..------------------------..-------EIRWNDETKRETLENLTDKEILRDFQLLSNQRNQQKREICRNCYQTGKRG---TIYGIPF-FYEGT.E.NWdssipkngkSA.EKGCIGCAWYDIERWRQELIKKL--....-----------k.........
K4RMW4_HELHE/1-188                 .....................................................................................................................m-----------------------SEFKGQYASLALGNGLSWELGSRSLAKKHRIKTDKSQTPGNAIR-ICLAGFNENVSF..NQSIRKDIREALEKSPVLCWALWGqvRTKNMKIEIDHQDGRKDDMRVSNQKTQQLGDFQPLCKAANDMKRQACKQCKEMGKRWDATQPLGNPHPFYAGD.E.NY.........DE.VLGCVGCYLYDPETYRKWT------....-----------ysqtphnk..
O25810_HELPY/1-158                 ......................................................................................................................-----------------------------------------------------MEFDKGQTLGNFIDRIRLNGYNTECVF..NQSICQDIKNHYKQQCCAMCGVRG..NSENTQIEVDHKDGRKDDSRVSDLSTQAFDDFQALCKACNDKKRQICKKCKETGYRFDARKIPGNHYSFYEGE.A.EY.........D-.--GCVGCYQYDPIQYRKTCNDRIYN....E----------gyqkgy....
Q7VHB6_HELHP/4-221                 ......................................................................................................................SKIEIFLELAKPDKNGISRWVSVSEFIGEYKALALGNGGSWCRASSTLAKKYILEFDKSKSAGNAIDAIRLKGFNTQKTF..NQAIRKDIKDFYKNQNCVMLGICG..KSENTKIEIDHKDGRKNDLRISNQQTQKLEDFQPLCKAANDVKRQICKVCRETNKRWSAKNIKGNPYAFYQGD.E.NY.........TQ.ELGCVGCYQYDPVAYRKESARKIAK....EAADFITQKLY..........
R5LIV2_9SPIR/1-120                 ......................................................................................................................--------------------------------------------------------------------------------..------------------MLGVCG..KSENTKIEIDHKDGRKNDYRVSDLKSQNINDFQPLCKAANDIKRQICKNCKKTNKRWNARNIRGNPYSFYAGD.E.NY.........TQ.ELGCVGCYQYDPVAYRKESVKKIAK....EAADYIASKLY..........
#=GC seq_cons                      ..........................................................................................................................lF.chA..spphhS+WlshsEF.GcYttLtLtNGhuWtRtsuslu+cYhlEhDKo.TsGNtlDtIRLsGFNpp.sa..NQsIRpDIKshhKsppCVhLGlsG..pS.NhpIEIDHKDGRKN-hRlss.poQpLpDFQPLsKAANDhKRQhCKpC+cTshRasA+plhG.PauFYtGD.E.pa.........sp.EhGClGCY.YDPlpaRKph...............................
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