GenomeNet

Database: Pfam
Entry: IGF2_C
LinkDB: IGF2_C
Original site: IGF2_C 
#=GF ID   IGF2_C
#=GF AC   PF08365.8
#=GF DE   Insulin-like growth factor II E-peptide
#=GF AU   Wuster A
#=GF SE   Pfam-B_4175 (release 18.0)
#=GF GA   21.00 21.00;
#=GF TC   22.60 21.60;
#=GF NC   20.40 20.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Insulin-like_growth_factor_2
#=GF RN   [1]
#=GF RM   8215015
#=GF RT   Insulin-like growth factors. 
#=GF RA   LeRoith D, Roberts CT Jr; 
#=GF RL   Ann N Y Acad Sci 1993;692:1-9.
#=GF RN   [2]
#=GF RM   12324491
#=GF RT   Antibodies directed against the E region of pro-insulin-like
#=GF RT   growth factor-II used to evaluate non-islet cell tumor-induced
#=GF RT   hypoglycemia. 
#=GF RA   van Doorn J, Hoogerbrugge CM, Koster JG, Bloemen RJ, Hoekman K,
#=GF RA   Mudde AH, van Buul-Offers SC; 
#=GF RL   Clin Chem 2002;48:1739-1750.
#=GF DR   INTERPRO; IPR013576;
#=GF CC   This domain is found at the C-terminal domain of the
#=GF CC   insulin-like growth factor II (IGF-2, also see Pfam:PF00049) in
#=GF CC   vertebrates and seems to represent the E-peptide [1,2].
#=GF SQ   60
#=GS G1KJ82_ANOCA/117-172      AC G1KJ82.1
#=GS W5P082_SHEEP/196-250      AC W5P082.1
#=GS F1PBX5_CANFA/115-169      AC F1PBX5.2
#=GS H2NCF8_PONAB/112-166      AC H2NCF8.1
#=GS A0A087Y814_POEFO/152-207  AC A0A087Y814.2
#=GS A9L955_PAPAN/115-169      AC A9L955.1
#=GS IGF2_CHICK/117-173        AC P33717.2
#=GS Q5MGT1_MELGA/117-173      AC Q5MGT1.1
#=GS M3Y2P9_MUSPF/115-169      AC M3Y2P9.1
#=GS H2RCZ8_PANTR/118-172      AC H2RCZ8.1
#=GS U3IZS4_ANAPL/125-164      AC U3IZS4.1
#=GS J9P961_CANFA/192-246      AC J9P961.1
#=GS J9NYS6_CANFA/118-172      AC J9NYS6.1
#=GS M7B4M1_CHEMY/172-227      AC M7B4M1.1
#=GS IGF2_MOUSE/112-166        AC P09535.1
#=GS E9QLW5_MOUSE/123-177      AC E9QLW5.1
#=GS IGF2_BOVIN/112-166        AC P07456.4
#=GS A0A0G2JTA6_RAT/123-177    AC A0A0G2JTA6.1
#=GS W5M137_LEPOC/148-203      AC W5M137.1
#=GS F7GYH4_CALJA/115-169      AC F7GYH4.1
#=GS Z4YJB4_CHICK/156-212      AC Z4YJB4.1
#=GS Q5U3B4_DANRE/129-184      AC Q5U3B4.1
#=GS IGF2_SHEEP/112-166        AC P10764.2
#=GS M4AM41_XIPMA/154-211      AC M4AM41.1
#=GS G1L5W6_AILME/169-223      AC G1L5W6.1
#=GS F7GMM5_CALJA/112-166      AC F7GMM5.1
#=GS IGF2_CAVPO/112-128        AC Q08279.1
#=GS G3RQ82_GORGO/112-166      AC G3RQ82.1
#=GS G3QMZ4_GORGO/168-222      AC G3QMZ4.1
#=GS G1RSQ4_NOMLE/115-169      AC G1RSQ4.1
#=GS L5KPG8_PTEAL/116-170      AC L5KPG8.1
#=GS W5LBM4_ASTMX/152-207      AC W5LBM4.1
#=GS IGF2_PIG/112-166          AC P23695.2
#=GS W5KJR7_ASTMX/146-200      AC W5KJR7.1
#=GS H3CYN8_TETNG/147-202      AC H3CYN8.1
#=GS F6QUB0_XENTR/150-205      AC F6QUB0.1
#=GS V8NR69_OPHHA/116-171      AC V8NR69.1
#=GS G3PAT8_GASAC/147-201      AC G3PAT8.1
#=GS A0A091DB43_FUKDA/168-222  AC A0A091DB43.1
#=GS IGF2_HORSE/112-166        AC P51459.2
#=GS F6XMS3_CALJA/168-222      AC F6XMS3.1
#=GS F6S666_HORSE/110-164      AC F6S666.1
#=GS H2MXF7_ORYLA/68-123       AC H2MXF7.1
#=GS Q8JIE4_DANRE/144-199      AC Q8JIE4.1
#=GS IGF2_RAT/112-166          AC P01346.1
#=GS A0JGX5_TAKRU/147-202      AC A0JGX5.1
#=GS IGF2_HUMAN/112-166        AC P01344.1
#=GS H0WB69_CAVPO/123-177      AC H0WB69.1
#=GS U3KAP3_FICAL/117-173      AC U3KAP3.1
#=GS G3HXZ9_CRIGR/87-141       AC G3HXZ9.1
#=GS A0A0D9RBQ8_CHLSB/168-222  AC A0A0D9RBQ8.1
#=GS L9LAE3_TUPCH/193-247      AC L9LAE3.1
#=GS I3N2V4_SPETR/195-249      AC I3N2V4.1
#=GS H0ZGA6_TAEGU/107-163      AC H0ZGA6.1
#=GS G3VK40_SARHA/116-170      AC G3VK40.1
#=GS G7PNW7_MACFA/129-183      AC G7PNW7.1
#=GS H3A5N5_LATCH/147-193      AC H3A5N5.1
#=GS G5C2F3_HETGA/168-222      AC G5C2F3.1
#=GS A9JSC3_XENTR/115-170      AC A9JSC3.1
#=GS I3KAU3_ORENI/147-202      AC I3KAU3.1
G1KJ82_ANOCA/117-172                 .....KYSKYDIWQKKSSQRLQRGVPNIHRAHRYRWQAEGLQESEESKI.HRPLMVLPTQKP............
W5P082_SHEEP/196-250                 .....KFFQSDTWKQ-STQRLRRGLPAFLRARRGRTLAKELEALREAKS.HRPLIALPTQDP............
F1PBX5_CANFA/115-169                 .....KFFQYDTWKQ-SAQRLRRGLPALLRARRGRMLAKELEAFREAKR.HRPLIALPTHDP............
H2NCF8_PONAB/112-166                 .....KFFQYDTWKQ-STQRLRRGLPALLRARRGHVLAKELEAFREAKR.HRPLIALPSQDP............
A0A087Y814_POEFO/152-207             .....KYSKYEVWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAKEQAIF.HRPLISLPSKLP............
A9L955_PAPAN/115-169                 .....KFFRYDTWKQ-STQRLRRGLPALLRARRGRVLAKELEAFREAKR.HRPLIALPTQDP............
IGF2_CHICK/117-173                   .....KYSKYNVWQKKSSQRLQREVPGILRARRYRWQAEGLQAAEEARAmHRPLISLPSQRP............
Q5MGT1_MELGA/117-173                 .....KYSKYNVWQKKSSQRLQREVPGILRARRYRWQAEGLQAAEEARAmHRPLISLPSQRP............
M3Y2P9_MUSPF/115-169                 .....KFFQYDTWKQ-SAQRLRRGLPALLRARRGRLLAKELEAFREAKR.HRPLIALPTHDP............
H2RCZ8_PANTR/118-172                 .....KFFQYDTWKQ-STQRLRRGLPALLRARRGHMLAKELEAFREAKR.HRPLIALPTQDP............
U3IZS4_ANAPL/125-164                 .....KYSKYDVWQKKSSQRLQREVPGILRAKKERGEKKK---------.------------eksel.......
J9P961_CANFA/192-246                 .....KFFQYDTWKQ-SAQRLRRGLPALLRARRGRMLAKELEAFREAKR.HRPLIALPTHDP............
J9NYS6_CANFA/118-172                 .....KFFQYDTWKQ-SAQRLRRGLPALLRARRGRMLAKELEAFREAKR.HRPLIALPTHDP............
M7B4M1_CHEMY/172-227                 .....KYSKYDVWQKKSSQRLQRGVPSILHARRYRWQAEGLQASDETKV.HRPLISLPSQKP............
IGF2_MOUSE/112-166                   .....KFFQYDTWRQ-SAGRLRRGLPALLRARRGRMLAKELKEFREAKR.HRPLIVLPPKDP............
E9QLW5_MOUSE/123-177                 .....KFFQYDTWRQ-SAGRLRRGLPALLRARRGRMLAKELKEFREAKR.HRPLIVLPPKDP............
IGF2_BOVIN/112-166                   .....KFFQYDIWKQ-STQRLRRGLPAFLRARRGRTLAKELEALREAKS.HRPLIALPTQDP............
A0A0G2JTA6_RAT/123-177               .....KFFKFDTWRQ-SAGRLRRGLPALLRARRGRMLAKELEAFREAKR.HRPLIVLPPKDP............
W5M137_LEPOC/148-203                 .....KYSKYDVWQRKAAQRLRRGIPAILRARKFRHQAEKVKAQEQLLF.HKPLITLPSKLP............
F7GYH4_CALJA/115-169                 .....KIFQYDTWKQ-STQRLRRTLPALLRNRRGRVLTKELELFREAKR.HRPLTALSTQDP............
Z4YJB4_CHICK/156-212                 .....KYSKYNVWQKKSSQRLQREVPGILRARRYRWQAEGLQAAEEARAmHRPLISLPSQRP............
Q5U3B4_DANRE/129-184                 .....KYSKYEVWQQKAAQRLRRGVPSILLARKFRRQMEKIQDEEQTSF.HRPLMTLPNRQP............
IGF2_SHEEP/112-166                   .....KFFQSDTWKQ-STQRLRRGLPAFLRARRGRTLAKELEALREAKS.HRPLIALPTQDP............
M4AM41_XIPMA/154-211                 .kypk--SGYELWDKNAARRLRRGVPAILRAKKFRRQAEKIKAKEQAIF.HRSLINLPSKLP............
G1L5W6_AILME/169-223                 .....KFFQYDTWKQ-SAQRLRRGLPALLRARRGRMLAKELEAFREAKR.HRPLIALPTHDP............
F7GMM5_CALJA/112-166                 .....KIFQYDTWKQ-STQRLRRTLPALLRNRRGRVLTKELELFREAKR.HRPLTALSTQDP............
IGF2_CAVPO/112-128                   .....KFFQYDTWRQ-STQRLRR--------------------------.------------............
G3RQ82_GORGO/112-166                 .....KFFQYDTWKQ-TTQRLRRGLPALLRARRGHVLAKELQAFREAKR.HRPLIALPTQDP............
G3QMZ4_GORGO/168-222                 .....KFFQYDTWKQ-TTQRLRRGLPALLRARRGHVLAKELQAFREAKR.HRPLIALPTQDP............
G1RSQ4_NOMLE/115-169                 .....KFFQYDTWKQ-STQRLRRGLPALLRARRGHVLAKELEAFREAKR.HRPLIALPTQDP............
L5KPG8_PTEAL/116-170                 .....KFFQYDSWMQ-SAQRLRRGLPALLRVRRGRMLARELEAFREATR.HRPLMALSTDDP............
W5LBM4_ASTMX/152-207                 .....RYSKYDQWQRRAAQRLRRGIPAILRSRKFRRQAEKIKAQEQANF.HKPLISLPSKLP............
IGF2_PIG/112-166                     .....KFFRYDTWKQ-SAQRLRRGLPALLRARRGRTLAKELEAVREAKR.HRPLTARPTRDP............
W5KJR7_ASTMX/146-200                 .....KFTKYEVWQQKA-QRLRRGVPNILRARNFRREAEKAQAQEGADI.HRPLMTVPNQRP............
H3CYN8_TETNG/147-202                 .....KYSKYEVWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAQEQTVF.HRPLISLPSKLP............
F6QUB0_XENTR/150-205                 .....KSSKYDIWQRKSIHRLRRGVPAIVRARQYRLLMQQAEESEQALS.HRPLTTLPITRP............
V8NR69_OPHHA/116-171                 .....KYSKYDIWQKKSSQRLQRGVPNVLRARRYRWQTEGLQESEESKN.HRPLVILPTQTP............
G3PAT8_GASAC/147-201                 .....KYSKYEVWQRKAAQRLRRG-PAILRARRFRRQEEKIKAQEQAVF.HRPLISLPSKLP............
A0A091DB43_FUKDA/168-222             .....KFFQYDTWRQ-STQRLRRGLPALLRARRGRMLSRELKAFREAKC.HHPLTVLTSKDP............
IGF2_HORSE/112-166                   .....KLFQYNAWKQ-STQRLRRGLPALLRTRRGRMLVKELEAFREAQR.HRPLIALPTEDP............
F6XMS3_CALJA/168-222                 .....KIFQYDTWKQ-STQRLRRTLPALLRNRRGRVLTKELELFREAKR.HRPLTALSTQDP............
F6S666_HORSE/110-164                 .....KLFQYNAWKQ-STQRLRRGLPALLRTRRGRMLVKELEAFREAQR.HRPLIALPTEDP............
H2MXF7_ORYLA/68-123                  rygdn-----KAWQRTAAQRLRRGVPAILRSKKFRRQAGKMKAQEEAVF.HRPLISLPSKLP............
Q8JIE4_DANRE/144-199                 .....KYSKYDVWQRKAAQRLRRGIPAILRAKKFRRQAERIKAQEQLLH.HRPLITLPSKLP............
IGF2_RAT/112-166                     .....KFFKFDTWRQ-SAGRLRRGLPALLRARRGRMLAKELEAFREAKR.HRPLIVLPPKDP............
A0JGX5_TAKRU/147-202                 .....KHSKYEVWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAQEQTVF.HRPLISLPSKLP............
IGF2_HUMAN/112-166                   .....KFFQYDTWKQ-STQRLRRGLPALLRARRGHVLAKELEAFREAKR.HRPLIALPTQDP............
H0WB69_CAVPO/123-177                 .....KFFQYDTWRQ-STQRLRRGLPALLRARRGRMLSKELEAFKEAKR.HHPLTVLTSKDP............
U3KAP3_FICAL/117-173                 .....KYSKYDVWQKKSSQRRQRDAPNILQARRYRWQAEGLQAAEEAKAlHRPLISLPSQRP............
G3HXZ9_CRIGR/87-141                  .....KFFQYDTWRK-SFQRLRRGLPALLRARRGRMLARELEAFREAKR.HRPLIALPPIDP............
A0A0D9RBQ8_CHLSB/168-222             .....KFFRYDTWKQ-STQRLRRGLPALLRARRGRVLAKELEAFREAKR.HRPLIALPTQDP............
L9LAE3_TUPCH/193-247                 .....KFFQYDTRKQ-STQRLRRGLSALLRARRGRMLARELEAFREVKR.HRPLIALSTQDP............
I3N2V4_SPETR/195-249                 .....KFFQYDTWRQ-SAQRLRRGLPALLRARRGRMLAKELEAFREAKR.HRPLIAMSSKDP............
H0ZGA6_TAEGU/107-163                 .....KYSKYDVWQKKSSQRRQRDAPNILRARRYRWQVEGLQAAEEAKAlHRPLISLPSQRP............
G3VK40_SARHA/116-170                 .....KFFKLDTWQK-SAHRLRRGLPALLRARRDRLRAQALEAIREAQR.HRALISLPSEDP............
G7PNW7_MACFA/129-183                 .....KFFRYDTWKQ-STQRLRRGLPALLRARRGRMLAKELEAFREAKR.HRPLIALPTQDP............
H3A5N5_LATCH/147-193                 .....RYSKYDWWQRKPAQRLRRGLPSIARAGKLRRLARA---------.------------rrpliarpsrhp
G5C2F3_HETGA/168-222                 .....KFFQYDTWRQ-STQRLRRGLPALLRARRGRMLSRELEALREAKR.HHPLTVLTSKDP............
A9JSC3_XENTR/115-170                 .....KSSKYDIWQRKSIHRLRRGVPAIVRARQYRLLMQQAEESEQALS.HRPLTTLPITRP............
I3KAU3_ORENI/147-202                 .....KYSKYEVWQRKAAQRLRRGVPAILRARKYKRHAEKIKAKEQAIF.HRPLISLPSKLP............
#=GC seq_cons                        .....KaFpYDsWpQ.SsQRLRRGLPAlLRARRtRhLA+cLcAhcEAKp.HRPLIuLPopcP............
//
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