GenomeNet

Database: Pfam
Entry: IGF2_C
LinkDB: IGF2_C
Original site: IGF2_C 
#=GF ID   IGF2_C
#=GF AC   PF08365.6
#=GF DE   Insulin-like growth factor II E-peptide
#=GF AU   Wuster A
#=GF SE   Pfam-B_4175 (release 18.0)
#=GF GA   21.00 21.00;
#=GF TC   21.50 22.00;
#=GF NC   20.20 20.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Insulin-like_growth_factor_2
#=GF RN   [1]
#=GF RM   8215015
#=GF RT   Insulin-like growth factors. 
#=GF RA   LeRoith D, Roberts CT Jr; 
#=GF RL   Ann N Y Acad Sci 1993;692:1-9.
#=GF RN   [2]
#=GF RM   12324491
#=GF RT   Antibodies directed against the E region of pro-insulin-like
#=GF RT   growth factor-II used to evaluate non-islet cell tumor-induced
#=GF RT   hypoglycemia. 
#=GF RA   van Doorn J, Hoogerbrugge CM, Koster JG, Bloemen RJ, Hoekman K,
#=GF RA   Mudde AH, van Buul-Offers SC; 
#=GF RL   Clin Chem 2002;48:1739-1750.
#=GF DR   INTERPRO; IPR013576;
#=GF CC   This domain is found at the C-terminal domain of the
#=GF CC   insulin-like growth factor II (IGF-2, also see Pfam:PF00049) in
#=GF CC   vertebrates and seems to represent the E-peptide [1,2].
#=GF SQ   168
#=GS G1KJ82_ANOCA/117-172  AC G1KJ82.1
#=GS Q0ZNC1_POELU/149-204  AC Q0ZNC1.1
#=GS IGF2_ONCMY/146-201    AC Q02816.1
#=GS Q28237_CEREL/17-57    AC Q28237.1
#=GS Q0ZNB8_9SMEG/148-203  AC Q0ZNB8.1
#=GS Q0ZNC6_9SMEG/148-203  AC Q0ZNC6.1
#=GS Q5MGT1_MELGA/117-173  AC Q5MGT1.1
#=GS B8QGI3_BOVIN/112-166  AC B8QGI3.1
#=GS Q0ZNB9_9SMEG/148-203  AC Q0ZNB9.1
#=GS H9CW50_MEGAM/144-199  AC H9CW50.1
#=GS Q153G7_CAPHI/112-166  AC Q153G7.1
#=GS E9PXP6_MOUSE/104-158  AC E9PXP6.1
#=GS Q5BQH2_9TELE/144-199  AC Q5BQH2.1
#=GS E9QLW5_MOUSE/123-177  AC E9QLW5.1
#=GS Q5Q0X5_EQUAS/74-115   AC Q5Q0X5.1
#=GS Q0ZNC2_9SMEG/148-203  AC Q0ZNC2.1
#=GS A0N9V1_ONCKE/146-201  AC A0N9V1.1
#=GS Q5U3B4_DANRE/129-184  AC Q5U3B4.1
#=GS IGF2_SHEEP/112-166    AC P10764.2
#=GS Q90XD0_CYPCA/144-199  AC Q90XD0.1
#=GS IGF2_CAVPO/112-128    AC Q08279.1
#=GS G1RSQ4_NOMLE/115-169  AC G1RSQ4.1
#=GS IGF2_PIG/112-166      AC P23695.2
#=GS Q0ZNA8_9SMEG/148-203  AC Q0ZNA8.1
#=GS Q4G1F4_SPAAU/147-202  AC Q4G1F4.1
#=GS D3YJ55_CERNI/169-223  AC D3YJ55.1
#=GS G1DGC9_CAPHI/112-166  AC G1DGC9.1
#=GS O73721_9CICH/147-202  AC O73721.1
#=GS Q0WY74_SOLSE/140-195  AC Q0WY74.1
#=GS Q0ZNC7_9SMEG/148-203  AC Q0ZNC7.1
#=GS F6S666_HORSE/110-164  AC F6S666.1
#=GS O73722_OREMO/147-202  AC O73722.1
#=GS Q9PUD0_DANRE/129-184  AC Q9PUD0.1
#=GS F1C2U6_9SMEG/144-199  AC F1C2U6.1
#=GS F1NBD6_CHICK/107-163  AC F1NBD6.1
#=GS A6XBL4_9PERO/122-163  AC A6XBL4.1
#=GS C1FXZ4_DASNO/117-171  AC C1FXZ4.1
#=GS H0WB69_CAVPO/123-177  AC H0WB69.1
#=GS Q0ZNA7_9SMEG/148-203  AC Q0ZNA7.1
#=GS Q0ZNC4_9SMEG/148-203  AC Q0ZNC4.1
#=GS H0ZGA6_TAEGU/107-163  AC H0ZGA6.1
#=GS D9ZZP9_PELFU/185-240  AC D9ZZP9.1
#=GS Q673F2_DIDMA/116-170  AC Q673F2.1
#=GS Q0ZNB4_9SMEG/148-205  AC Q0ZNB4.1
#=GS G3VK40_SARHA/116-170  AC G3VK40.1
#=GS Q5MBR1_DICLA/147-202  AC Q5MBR1.1
#=GS E5G0S5_CYPCA/135-190  AC E5G0S5.1
#=GS A9JSC3_XENTR/115-170  AC A9JSC3.1
#=GS IGF2B_XENLA/150-205   AC Q6INW9.2
#=GS Q0ZNC8_9SMEG/148-205  AC Q0ZNC8.1
#=GS Q0ZNC5_9SMEG/148-203  AC Q0ZNC5.1
#=GS Q9MYX4_BOSIN/82-136   AC Q9MYX4.1
#=GS G1E6K2_PSEMX/151-206  AC G1E6K2.1
#=GS Q0ZNB1_9SMEG/142-197  AC Q0ZNB1.1
#=GS Q6Q8B4_EPICO/147-202  AC Q6Q8B4.1
#=GS A9L955_PAPAN/115-169  AC A9L955.1
#=GS F6KZW8_SHEEP/112-166  AC F6KZW8.1
#=GS IGF2_CHICK/117-173    AC P33717.2
#=GS C6KPE2_MICSA/147-202  AC C6KPE2.1
#=GS Q2IDG7_MUSSP/123-177  AC Q2IDG7.1
#=GS D3YJ53_CERNI/112-166  AC D3YJ53.1
#=GS H2RCZ8_PANTR/118-172  AC H2RCZ8.1
#=GS C6GBY8_ONCMY/146-201  AC C6GBY8.1
#=GS A3E108_MONDO/116-170  AC A3E108.1
#=GS F7GYH4_CALJA/115-169  AC F7GYH4.1
#=GS Q0ZND1_9SMEG/148-203  AC Q0ZND1.1
#=GS Q673F3_ORNAN/174-225  AC Q673F3.1
#=GS F7GMM5_CALJA/112-166  AC F7GMM5.1
#=GS Q8UWF9_SALSA/57-92    AC Q8UWF9.1
#=GS F6QUB0_XENTR/150-205  AC F6QUB0.1
#=GS H6ULE9_RUTRU/102-141  AC H6ULE9.1
#=GS IGF2_MUSVI/113-129    AC P41694.1
#=GS A1Z5I5_CEREL/112-166  AC A1Z5I5.1
#=GS H2MXF7_ORYLA/68-123   AC H2MXF7.1
#=GS A8K6C9_HUMAN/112-166  AC A8K6C9.1
#=GS IGF2_HUMAN/112-166    AC P01344.1
#=GS Q9DET4_MYOSC/99-154   AC Q9DET4.1
#=GS Q53WT7_RAT/10-64      AC Q53WT7.1
#=GS Q0ZNC9_9SMEG/148-203  AC Q0ZNC9.1
#=GS B0Z6G5_ORENI/147-202  AC B0Z6G5.1
#=GS Q0ZNB2_9SMEG/142-197  AC Q0ZNB2.1
#=GS Q52ZH5_9SMEG/147-202  AC Q52ZH5.1
#=GS Q0ZNC0_POEOC/148-203  AC Q0ZNC0.1
#=GS Q2IDG5_MUSSP/112-166  AC Q2IDG5.1
#=GS G5C2F3_HETGA/168-222  AC G5C2F3.1
#=GS G1JRQ3_9TELE/140-195  AC G1JRQ3.1
#=GS E0W6Z3_CANFA/113-167  AC E0W6Z3.1
#=GS E2IBU0_CAPHI/2-56     AC E2IBU0.1
#=GS G9BFT6_PIG/115-169    AC G9BFT6.1
#=GS Q0ZNB6_9SMEG/148-203  AC Q0ZNB6.1
#=GS B0Z831_AMPCL/88-132   AC B0Z831.1
#=GS Q8UUI9_DANRE/129-184  AC Q8UUI9.1
#=GS Q800E6_PAROL/147-202  AC Q800E6.1
#=GS Q0ZNA9_POERE/148-206  AC Q0ZNA9.1
#=GS Q0ZNB3_9SMEG/148-203  AC Q0ZNB3.1
#=GS Q5U8T7_EPICO/155-178  AC Q5U8T7.1
#=GS Q9N1S5_CAPCA/72-113   AC Q9N1S5.1
#=GS IGF2_BOVIN/112-166    AC P07456.4
#=GS G7NBL8_MACMU/129-183  AC G7NBL8.1
#=GS D2HDS8_AILME/113-167  AC D2HDS8.1
#=GS G1L5W6_AILME/169-223  AC G1L5W6.1
#=GS A8CG85_DIPSG/147-202  AC A8CG85.2
#=GS G3RQ82_GORGO/112-166  AC G3RQ82.1
#=GS A0N0D9_CTEID/144-199  AC A0N0D9.1
#=GS G3QMZ4_GORGO/168-222  AC G3QMZ4.1
#=GS Q0ZNB7_9SMEG/148-203  AC Q0ZNB7.1
#=GS H3CYN8_TETNG/147-202  AC H3CYN8.1
#=GS G3PAT8_GASAC/147-201  AC G3PAT8.1
#=GS B7TY34_CARAU/133-188  AC B7TY34.1
#=GS C9JAF2_HUMAN/168-222  AC C9JAF2.2
#=GS B0LAD8_MOUSE/12-66    AC B0LAD8.1
#=GS F6XMS3_CALJA/168-222  AC F6XMS3.1
#=GS E3TBW3_9TELE/140-195  AC E3TBW3.1
#=GS B3RFH2_SORAR/112-166  AC B3RFH2.1
#=GS Q8JIE4_DANRE/144-199  AC Q8JIE4.1
#=GS A0JGX5_TAKRU/147-202  AC A0JGX5.1
#=GS Q2F6J9_BOVIN/34-88    AC Q2F6J9.1
#=GS Q6T8S1_MUGCE/147-188  AC Q6T8S1.1
#=GS A7BK21_ANGJA/145-200  AC A7BK21.1
#=GS G9BFT5_PIG/112-166    AC G9BFT5.1
#=GS Q52ZH4_9SMEG/148-205  AC Q52ZH4.1
#=GS A4UQM1_MESAU/28-64    AC A4UQM1.1
#=GS Q800Y4_SIGGU/147-202  AC Q800Y4.1
#=GS F8U8T2_CHELB/103-158  AC F8U8T2.1
#=GS D3YJ54_CERNI/197-251  AC D3YJ54.1
#=GS O57687_TAEGU/117-173  AC O57687.1
#=GS Q9N171_ORNAN/86-137   AC Q9N171.2
#=GS B5TZR4_BOSMU/10-64    AC B5TZR4.1
#=GS Q862E7_BOVIN/46-100   AC Q862E7.1
#=GS Q9PU30_OREMO/70-125   AC Q9PU30.1
#=GS H3A5N5_LATCH/147-193  AC H3A5N5.1
#=GS E3TG04_ICTPU/140-195  AC E3TG04.1
#=GS O42429_LATCA/147-202  AC O42429.1
#=GS H8XX14_GADMO/138-193  AC H8XX14.1
#=GS H2NCF8_PONAB/112-166  AC H2NCF8.1
#=GS Q4SDZ0_TETNG/96-151   AC Q4SDZ0.1
#=GS B9VVQ5_9PERC/144-199  AC B9VVQ5.1
#=GS D7PCU1_TRIVU/94-133   AC D7PCU1.1
#=GS H2DFT7_LATJA/119-169  AC H2DFT7.1
#=GS Q0ZNB5_9SMEG/147-205  AC Q0ZNB5.1
#=GS Q0ZND2_9SMEG/147-202  AC Q0ZND2.1
#=GS IGF2_MOUSE/112-166    AC P09535.1
#=GS B3TFF0_PIG/104-158    AC B3TFF0.1
#=GS Q9PTB0_CHICK/65-121   AC Q9PTB0.1
#=GS G9K5B9_MUSPF/94-148   AC G9K5B9.1
#=GS B7NZU3_RABIT/113-166  AC B7NZU3.1
#=GS IGF2A_XENLA/150-205   AC Q90WW4.1
#=GS Q8WNP3_9MAMM/57-108   AC Q8WNP3.1
#=GS A4GUE9_SALSA/146-201  AC A4GUE9.1
#=GS Q0ZND0_9SMEG/148-203  AC Q0ZND0.1
#=GS IGF2_HORSE/112-166    AC P51459.2
#=GS Q63265_RAT/86-140     AC Q63265.1
#=GS F1PBX5_CANFA/125-179  AC F1PBX5.1
#=GS E0YC42_SALAL/146-201  AC E0YC42.1
#=GS IGF2_RAT/112-166      AC P01346.1
#=GS E0W6Z5_CANFA/116-170  AC E0W6Z5.1
#=GS A5JSG9_SPAAU/147-202  AC A5JSG9.1
#=GS G3HXZ9_CRIGR/87-141   AC G3HXZ9.1
#=GS Q24K65_9PERO/107-162  AC Q24K65.1
#=GS Q0ZNB0_9SMEG/144-199  AC Q0ZNB0.1
#=GS B6UM04_BUBBU/61-107   AC B6UM04.1
#=GS E2FKK6_SINCH/147-202  AC E2FKK6.1
#=GS Q862G1_BOVIN/82-138   AC Q862G1.1
#=GS G7PNW7_MACFA/129-183  AC G7PNW7.1
#=GS Q0ZNC3_9SMEG/148-203  AC Q0ZNC3.1
#=GS H6WS83_BOSIN/10-64    AC H6WS83.1
#=GS A8CG81_9PERO/147-202  AC A8CG81.1
#=GS B2ZRV8_HIPHI/138-162  AC B2ZRV8.1
G1KJ82_ANOCA/117-172             ......KYSK..YD..IWQKKSSQRLQRGVPNIHRAHRYRWQAEGLQESEESK.IHRPLMVLPTQKP..............
Q0ZNC1_POELU/149-204             ......KYPK..YV..VWPRKAAERLRRGVPAILRSKKFRRQAEKIKAKEQAI.FHRPLISLPSKLP..............
IGF2_ONCMY/146-201               ......KYSK..YE..AWQRKAAQRLRRGVPAILRARKFRRQAVKIKAQEQAM.FHRPLITLPSKLP..............
Q28237_CEREL/17-57               ......KLFR..HD..TRK-QSTQRLRRGLPAFLRARRGRTLAQELEALREA-.-------------..............
Q0ZNB8_9SMEG/148-203             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAKEQAN.FHRPLISLPSKLP..............
Q0ZNC6_9SMEG/148-203             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAKEQAI.FHRPLISLPSKLP..............
Q5MGT1_MELGA/117-173             ......KYSK..YN..VWQKKSSQRLQREVPGILRARRYRWQAEGLQAAEEARaMHRPLISLPSQRP..............
B8QGI3_BOVIN/112-166             ......KFFQ..YD..IWK-QSTQRLRRGLPAFLRARRGRTLAKELEALREAK.SHRPLIALPTQDP..............
Q0ZNB9_9SMEG/148-203             ......KYSK..YE..VWQRKATQRLRRGVPAILRAKKFRRQAEKIKAKEQAN.FHRPLISLPSKLP..............
H9CW50_MEGAM/144-199             ......KYSK..YD..VWQRKAAQRLRRGVPAILRAKKFRRQAERIKAQEQLH.HHRPLITLPSKLP..............
Q153G7_CAPHI/112-166             ......KFFQ..SD..TWK-QSTQRLRRGLPAFLRARRGRTLAKELEALREAK.SHRPLIALPTQDP..............
E9PXP6_MOUSE/104-158             ......KFFQ..YD..TWR-QSAGRLRRGLPALLRARRGRMLAKELKEFREAK.RHRPLIVLPPKDP..............
Q5BQH2_9TELE/144-199             ......KYSK..YD..MWQRKAAQRLRRGIPAILRAKKFRRQAKRIRAQEQLY.NHRPLITLPSKLP..............
E9QLW5_MOUSE/123-177             ......KFFQ..YD..TWR-QSAGRLRRGLPALLRARRGRMLAKELKEFREAK.RHRPLIVLPPKDP..............
Q5Q0X5_EQUAS/74-115              ......KLFQ..YN..AWK-QSTQRLRRGLPALLRTRRGRMLVKELEAFREAQ.-------------..............
Q0ZNC2_9SMEG/148-203             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAKEQAI.FHRPLISLPSKLP..............
A0N9V1_ONCKE/146-201             ......KYSK..YE..AWQRKAAQRLRRGVPAILRARKFRRQAVKIKAQEQAM.FHRPLITLPSKLP..............
Q5U3B4_DANRE/129-184             ......KYSK..YE..VWQQKAAQRLRRGVPSILLARKFRRQMEKIQDEEQTS.FHRPLMTLPNRQP..............
IGF2_SHEEP/112-166               ......KFFQ..SD..TWK-QSTQRLRRGLPAFLRARRGRTLAKELEALREAK.SHRPLIALPTQDP..............
Q90XD0_CYPCA/144-199             ......KYSK..YD..MWQRKAAQRLRRGVPAILRAKKFRRQAERIRAQEQLH.HHRPLITLPSKLP..............
IGF2_CAVPO/112-128               ......KFFQ..YD..TWR-QSTQRLRR-------------------------.-------------..............
G1RSQ4_NOMLE/115-169             ......KFFQ..YD..TWK-QSTQRLRRGLPALLRARRGHVLAKELEAFREAK.RHRPLIALPTQDP..............
IGF2_PIG/112-166                 ......KFFR..YD..TWK-QSAQRLRRGLPALLRARRGRTLAKELEAVREAK.RHRPLTARPTRDP..............
Q0ZNA8_9SMEG/148-203             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAKEQAI.FHRPLISLPSKLP..............
Q4G1F4_SPAAU/147-202             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKYRRQAEKIKAQEQAI.FHRPLISLPSKLP..............
D3YJ55_CERNI/169-223             ......KLFR..HD..TRK-QSTQRLRRGLPAFLRARRGRTLAQELEALREAK.SHRPLITLPIQDP..............
G1DGC9_CAPHI/112-166             ......KFFQ..SD..PWK-QSPQRLRRGLPAFLRAPRGRTLAKELEALREAK.SHRPLIALPTRAP..............
O73721_9CICH/147-202             ......KYSK..YE..VWQRKAAQRLRRGVPAILRARKYKRHAEKIKAKEQAI.FHRPLISLPSKLP..............
Q0WY74_SOLSE/140-195             ......RYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAENIKAQEQAI.FHRPLISLPSKLP..............
Q0ZNC7_9SMEG/148-203             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAEEQAI.FHRPLISLPSKLP..............
F6S666_HORSE/110-164             ......KLFQ..YN..AWK-QSTQRLRRGLPALLRTRRGRMLVKELEAFREAQ.RHRPLIALPTEDP..............
O73722_OREMO/147-202             ......KYSK..YE..VWQRKAAQRLRRGVPAILRARKYKRHAEKIKAKEQAI.FHRPLISLPSKLP..............
Q9PUD0_DANRE/129-184             ......KYSK..YE..VWQQKAAQRLRRGVPSILLARKFRRQMEKIQDEEQTS.FHRPLMTLPNRQP..............
F1C2U6_9SMEG/144-199             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAQEESV.FHRPLISLPSKLP..............
F1NBD6_CHICK/107-163             ......KYSK..YN..VWQKKSSQRLQREVPGILRARRYRWQAEGLQAAEEARaMHRPLISLPSQRP..............
A6XBL4_9PERO/122-163             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAQEQA-.-------------..............
C1FXZ4_DASNO/117-171             .....r-LFQ..HD..TWK-HSTQRLRRGLPAALRAGQGRVLAKELAAFRKAL.RRRPLTALPTRDP..............
H0WB69_CAVPO/123-177             ......KFFQ..YD..TWR-QSTQRLRRGLPALLRARRGRMLSKELEAFKEAK.RHHPLTVLTSKDP..............
Q0ZNA7_9SMEG/148-203             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAKEQAI.FHRPLISLPSKLP..............
Q0ZNC4_9SMEG/148-203             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAKEQAI.FHRPLISLPSKLP..............
H0ZGA6_TAEGU/107-163             ......KYSK..YD..VWQKKSSQRRQRDAPNILRARRYRWQVEGLQAAEEAKaLHRPLISLPSQRP..............
D9ZZP9_PELFU/185-240             ......KYSS..IG..VWQQNAAQRLRRGIPAILRSRKFSPQAQKKKNQEQAN.VHKRLITLPSKRP..............
Q673F2_DIDMA/116-170             ......RFFK..LD..TWQ-KSAHRLRRGLPALLRARRDRLRAQALEAIREAK.RHRPLITLPSEDP..............
Q0ZNB4_9SMEG/148-205             ......KYSK..YEfqMWDRNAAQRLRRGVPAILRAKKFRRQAEKIKAKEQAI.FHRPLISLPSKLP..............
G3VK40_SARHA/116-170             ......KFFK..LD..TWQ-KSAHRLRRGLPALLRARRDRLRAQALEAIREAQ.RHRALISLPSEDP..............
Q5MBR1_DICLA/147-202             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKYRRQAEKIKAQEQAI.FHRPLISLPSKLP..............
E5G0S5_CYPCA/135-190             ......KYSK..YE..VWQRKPAQRLRRGVPSILLARKFRRQVEKIQDEEQVS.FHRPLMTLPNGHP..............
A9JSC3_XENTR/115-170             ......KSSK..YD..IWQRKSIHRLRRGVPAIVRARQYRLLMQQAEESEQAL.SHRPLTTLPITRP..............
IGF2B_XENLA/150-205              ......KSSK..YD..IWQRKSIHRLRRGVPAIVRARQYRLLMQKAEESEQAL.LHRPLTTLPITRP..............
Q0ZNC8_9SMEG/148-205             ......KYSKneYE..LWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAKEQAI.FHRPLISLPSKLP..............
Q0ZNC5_9SMEG/148-203             ......KYSK..YE..VWQRRAAQRLRRGVPAILRAKKFRRQAEKIKAKEQAI.FHRPLISLPSKLP..............
Q9MYX4_BOSIN/82-136              ......KFFQ..YD..IWK-QSTQRLRRGLPAFLRARRGRTLAKELEALREAK.SHRPLIALPTQDP..............
G1E6K2_PSEMX/151-206             ......KYSK..YE..VWQRNAAQRLRRGVPAILRAKKFRRQAEKIKAQEQAI.FHRPLISLPSKLP..............
Q0ZNB1_9SMEG/142-197             ......KYTI..YV..VWDRNAARRLRRGVPAILRAKKFRRQSEKVKAKEQAI.FHRSLISLPSELP..............
Q6Q8B4_EPICO/147-202             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAQEQAV.FHRPLISLPSKLP..............
A9L955_PAPAN/115-169             ......KFFR..YD..TWK-QSTQRLRRGLPALLRARRGRVLAKELEAFREAK.RHRPLIALPTQDP..............
F6KZW8_SHEEP/112-166             ......KFFQ..SD..TWK-QSTQRLRRGLPAFLRARRGRTLAKELEALREAK.SHRPLIALPTQDP..............
IGF2_CHICK/117-173               ......KYSK..YN..VWQKKSSQRLQREVPGILRARRYRWQAEGLQAAEEARaMHRPLISLPSQRP..............
C6KPE2_MICSA/147-202             ......KYSK..YE..AWQRKAAQRLRRGVPAILRAKRFRRQAEKIKAQEQAI.LHRPLISLPSKLP..............
Q2IDG7_MUSSP/123-177             ......KFFQ..YD..TWR-QSAGRLRRGLPALLRARRGRMLAKELKAFSEAK.RHRPLIVLPPKDP..............
D3YJ53_CERNI/112-166             ......KLFR..HD..TRK-QSTQRLRRGLPAFLRARRGRTLAQELEALREAK.SHRPLITLPIQDP..............
H2RCZ8_PANTR/118-172             ......KFFQ..YD..TWK-QSTQRLRRGLPALLRARRGHMLAKELEAFREAK.RHRPLIALPTQDP..............
C6GBY8_ONCMY/146-201             ......KYSK..YE..AWQRKAAQRLRRGVPAILRARKFRRQAVKIKAQEQAM.FHRPLITLPSKLP..............
A3E108_MONDO/116-170             ......RFFK..LD..TWQ-KSAHRLRRGLPALLRARRDRLRAQALDAIREAK.RHRPLISLPSGDP..............
F7GYH4_CALJA/115-169             ......KIFQ..YD..TWK-QSTQRLRRTLPALLRNRRGRVLTKELELFREAK.RHRPLTALSTQDP..............
Q0ZND1_9SMEG/148-203             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAQEQAI.FHRPLISLPSKLP..............
Q673F3_ORNAN/174-225             ......KFFR..DE..SWQ-KSAHRLRRGAPAQARLRRFRPLADPRHGSQ---.LFRPLGPLPGEQP..............
F7GMM5_CALJA/112-166             ......KIFQ..YD..TWK-QSTQRLRRTLPALLRNRRGRVLTKELELFREAK.RHRPLTALSTQDP..............
Q8UWF9_SALSA/57-92               ......KYSK..YE..VWQRKAAQRLRRGVPAILRARKFRRQAVK--------.-------------t.............
F6QUB0_XENTR/150-205             ......KSSK..YD..IWQRKSIHRLRRGVPAIVRARQYRLLMQQAEESEQAL.SHRPLTTLPITRP..............
H6ULE9_RUTRU/102-141             ......KYSK..YD..VWQRKAAQRLRRGVPAILRAKKFRRQAERIKAQE---.-------------..............
IGF2_MUSVI/113-129               ......KFFQ..YD..TWK-QSAQRLRR-------------------------.-------------..............
A1Z5I5_CEREL/112-166             ......KLFR..HD..TRK-QSTQRLRRGLPAFLRARRGRTLAQELEALREAK.SHRPLITLPIQDP..............
H2MXF7_ORYLA/68-123              ..rygd----..NK..AWQRTAAQRLRRGVPAILRSKKFRRQAGKMKAQEEAV.FHRPLISLPSKLP..............
A8K6C9_HUMAN/112-166             ......KFFQ..YD..TWK-QSTQRLRRGLPALLRARRGHVLAKELEAFREAK.RHRPLIALPTQDP..............
IGF2_HUMAN/112-166               ......KFFQ..YD..TWK-QSTQRLRRGLPALLRARRGHVLAKELEAFREAK.RHRPLIALPTQDP..............
Q9DET4_MYOSC/99-154              ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAQEQGV.FNRPLISLPSKLP..............
Q53WT7_RAT/10-64                 ......KFFK..FD..TWR-QSAGRLRRGLPALLRARRGRMLAKELEAFREAK.RHRPLIVLPPKDP..............
Q0ZNC9_9SMEG/148-203             ......KYSK..YE..VWQRRAAQRLRRGVPAILRAKKFRRQAEKIKAKEQAI.FHRPLISLPSKLP..............
B0Z6G5_ORENI/147-202             ......KYSK..YE..VWQRKAAQRLRRGVPAILRARKYKRHAEKIKAKEQAI.FHRPLISLPSSWP..............
Q0ZNB2_9SMEG/142-197             ......KYTI..YE..VWDRNAARRLRRGVPAILRAKKFRRQAEKVKAKEQAI.FHRPLISLPSKLP..............
Q52ZH5_9SMEG/147-202             ......KFPK..YV..VWPRRAAERLRRGVPAILRSKKFRRQAEKIKAKEQAI.FHRPLISLPSKLP..............
Q0ZNC0_POEOC/148-203             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAKEQAI.FHRPLISLPSKLP..............
Q2IDG5_MUSSP/112-166             ......KFFQ..YD..TWR-QSAGRLRRGLPALLRARRGRMLAKELKAFSEAK.RHRPLIVLPPKDP..............
G5C2F3_HETGA/168-222             ......KFFQ..YD..TWR-QSTQRLRRGLPALLRARRGRMLSRELEALREAK.RHHPLTVLTSKDP..............
G1JRQ3_9TELE/140-195             ......QFSR..YE..QWQRIAAQRLRRGIPPILRSRKFKRLAKKIQDQEQQE.FHRPLMTVSNRSP..............
E0W6Z3_CANFA/113-167             ......KFFQ..YD..TWK-QSAQRLRRGLPALLRARRGRMLAKELEAFREAK.RHRPLIALPTHDP..............
E2IBU0_CAPHI/2-56                ......KFFQ..SD..TWK-QSTQRLRRGLPAFLRARRGRTLAKELEALREAK.SHRPLIALPTQDP..............
G9BFT6_PIG/115-169               ......KFFR..YD..TWK-QSAQRLRRGLPALLRARRGRTLAKELEAVREAK.RHRPLTARPTRDP..............
Q0ZNB6_9SMEG/148-203             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAKEQAI.FHRPLISLPSKLP..............
B0Z831_AMPCL/88-132              ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAQEQSI.FH-----------..............
Q8UUI9_DANRE/129-184             ......KYSK..YE..VWQQKAAQRLRRGVPSILLARKFRRQMEKIQDEEQTS.FHRPLMTLPNRQP..............
Q800E6_PAROL/147-202             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAQEQAI.FHRPLISLPSKLP..............
Q0ZNA9_POERE/148-206             kysrad---E..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAKEQAI.FHRPLISLPSKLP..............
Q0ZNB3_9SMEG/148-203             ......KYSK..YE..VWDMKAAQRLRRGVPAILRAKKFRRQAEKIKAKEQAI.FHRPLISLPSKLP..............
Q5U8T7_EPICO/155-178             ......----..--..----------------------FRRQAEKIKAQEQAV.HHRPLITLP----..............
Q9N1S5_CAPCA/72-113              ......KFFR..YD..TWK-QSTQRLRRGLPAFLRVRRGRTLAKELEALREAK.-------------..............
IGF2_BOVIN/112-166               ......KFFQ..YD..IWK-QSTQRLRRGLPAFLRARRGRTLAKELEALREAK.SHRPLIALPTQDP..............
G7NBL8_MACMU/129-183             ......KFFR..YD..TWK-QSTQRLRRGLPALLRARRGRMLAKELEAFREAK.RHRPLIALPTQDP..............
D2HDS8_AILME/113-167             ......KFFQ..YD..TWK-QSAQRLRRGLPALLRARRGRMLAKELEAFREAK.RHRPLIALPTHDP..............
G1L5W6_AILME/169-223             ......KFFQ..YD..TWK-QSAQRLRRGLPALLRARRGRMLAKELEAFREAK.RHRPLIALPTHDP..............
A8CG85_DIPSG/147-202             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKYRRQAEKIKAQEQAI.FHRPLISLPSKLP..............
G3RQ82_GORGO/112-166             ......KFFQ..YD..TWK-QTTQRLRRGLPALLRARRGHVLAKELQAFREAK.RHRPLIALPTQDP..............
A0N0D9_CTEID/144-199             ......KYSK..YD..VWQRKAAQRLRRGVPAILRAKKFRRQAERIKAQEQLH.HHRPLITLPSKLP..............
G3QMZ4_GORGO/168-222             ......KFFQ..YD..TWK-QTTQRLRRGLPALLRARRGHVLAKELQAFREAK.RHRPLIALPTQDP..............
Q0ZNB7_9SMEG/148-203             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAKEQAI.FHRPLISLPSKLP..............
H3CYN8_TETNG/147-202             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAQEQTV.FHRPLISLPSKLP..............
G3PAT8_GASAC/147-201             ......KYSK..YE..VWQRKAAQRLRRG-PAILRARRFRRQEEKIKAQEQAV.FHRPLISLPSKLP..............
B7TY34_CARAU/133-188             ......KYSK..YE..VWQRKAAQRLRRGVPSILLARKFRRQMEKIQDEEQAR.FHRPLMTLPDRHP..............
C9JAF2_HUMAN/168-222             ......KFFQ..YD..TWK-QSTQRLRRGLPALLRARRGHVLAKELEAFREAK.RHRPLIALPTQDP..............
B0LAD8_MOUSE/12-66               ......KFFQ..YD..TWR-QSAGRLRRGLPALLRARRGRMLAKELKEFREAK.RHRPLIVLPPKDP..............
F6XMS3_CALJA/168-222             ......KIFQ..YD..TWK-QSTQRLRRTLPALLRNRRGRVLTKELELFREAK.RHRPLTALSTQDP..............
E3TBW3_9TELE/140-195             ......RFSR..YE..LWQRTAAQRLRRGIPPILRSRKFKRLAEKSQDQEQTQ.IHRPLMTVSNRG-p.............
B3RFH2_SORAR/112-166             ......QFFQ..YD..SWK-QSAQRLRRGLPALLRARRGRLLAKELEAFREAQ.RHRALTTFPTQDP..............
Q8JIE4_DANRE/144-199             ......KYSK..YD..VWQRKAAQRLRRGIPAILRAKKFRRQAERIKAQEQLL.HHRPLITLPSKLP..............
A0JGX5_TAKRU/147-202             ......KHSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAQEQTV.FHRPLISLPSKLP..............
Q2F6J9_BOVIN/34-88               ......KFFQ..YD..IWK-QSTQRLRRGLPAFLRARRGRTLAKELEALREAK.SHRPLIALPTQDP..............
Q6T8S1_MUGCE/147-188             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAQEQ--.-------------s.............
A7BK21_ANGJA/145-200             ......KYSK..YE..VWQRKAAQRLRRGVPAVLRSRKFRRQGDMARAQEQAE.SHRHLMTLPARLP..............
G9BFT5_PIG/112-166               ......KFFR..YD..TWK-QSAQRLRRGLPALLRARRGRTLAKELEAVREAK.RHRPLTARPTRDP..............
Q52ZH4_9SMEG/148-205             ......KYSKneYE..VWQRNAAQRLRRGVPAILRAKKFRRQAEKIKAKEQAI.FHRPLISLPSKLP..............
A4UQM1_MESAU/28-64               ......KFFQ..YD..TWR-QSFQRLRRGLPALLRARRGRMLARELEA-----.-------------..............
Q800Y4_SIGGU/147-202             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAQEQAI.FHRPLISLPSKLP..............
F8U8T2_CHELB/103-158             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAQEQSI.FHRPLISLPSKLP..............
D3YJ54_CERNI/197-251             ......KLFR..HD..TRK-QSTQRLRRGLPAFLRARRGRTLAQELEALREAK.SHRPLITLPIQDP..............
O57687_TAEGU/117-173             ......KYSK..YD..VWQKKSSQRRQRDAPNILRARRYRWQVEGLQAAEEAKaLHRPLISLPSQRP..............
Q9N171_ORNAN/86-137              ......KFFR..DE..SWQ-KSAHRLRRGAPAQARLRRFRPLADPRHGSQ---.LFRPLGPLPGEQP..............
B5TZR4_BOSMU/10-64               ......KFFQ..YD..IWK-QSTQRLRRGLPAFLRARRGRTLAKELEALREAK.SHRPLIALPTQDP..............
Q862E7_BOVIN/46-100              ......KFFQ..YD..IWK-QSTQRLRRGLPAFLRARRGRTLAKELEALREAK.SHRPLIALPTQDP..............
Q9PU30_OREMO/70-125              ......KYSK..YE..VWQRKAAQRLRRGVPAILRARKYKRHAEKIKAKEQAI.FHRPAISLPSKLP..............
H3A5N5_LATCH/147-193             ......RYSK..YD..WWQRKPAQRLRRGLPSIARAGKLRRLARA----R---.--RPLIARPSRHP..............
E3TG04_ICTPU/140-195             ......RFSR..YE..LWQRTAAQRLRRGIPPILRSRKFKRLAEKSQDQEQTQ.IHRPLMTVSNRSP..............
O42429_LATCA/147-202             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAQEQVI.FHRPLISLPSKLP..............
H8XX14_GADMO/138-193             ......KLSS..YA..VWDRKAAQRLRRGIPAILKARKFRRQAEKARAKAQEQ.THRPLISLPSKLP..............
H2NCF8_PONAB/112-166             ......KFFQ..YD..TWK-QSTQRLRRGLPALLRARRGHVLAKELEAFREAK.RHRPLIALPSQDP..............
Q4SDZ0_TETNG/96-151              ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAQEQTV.FHRPLISLPSKLP..............
B9VVQ5_9PERC/144-199             ......KVSK..YE..VWQRKAAQRLRRGVPAILRAKKFRKQAEKIKAQEQAI.FHRPLISLPSKLP..............
D7PCU1_TRIVU/94-133              ......KFFR..LD..TWQ-KSARRLRRGLPALLRARRDRLRAQALEAIRE--.-------------..............
H2DFT7_LATJA/119-169             ......KYSK..YE..MWQRKAAQRLRRGVPAILIAKRNRRQAEKIKAREQAI.FHRPLITL-----..............
Q0ZNB5_9SMEG/147-205             kysrad---E..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAKEQAI.FHRPLISLPSKLP..............
Q0ZND2_9SMEG/147-202             ......KYPT..YE..TWQKKAAQRLRRGIPAILRAKKFRRQAQKMKAQEQAV.IHRPLISLPSKLP..............
IGF2_MOUSE/112-166               ......KFFQ..YD..TWR-QSAGRLRRGLPALLRARRGRMLAKELKEFREAK.RHRPLIVLPPKDP..............
B3TFF0_PIG/104-158               ......KFFR..YD..TWK-QSAQRLRRGLPALLRARRGRTLAKELEAVREAK.RHRPLTARPTRDP..............
Q9PTB0_CHICK/65-121              ......KYSK..YN..VWQKKSSQRLQREVPGILRARRYRWQAEGLQAAEEARaMHRPLISLPSQRP..............
G9K5B9_MUSPF/94-148              ......KFFQ..YD..TWK-QSAQRLRRGLPALLRARRGRLLAKELEAFREAK.RHRPLIALPTHDP..............
B7NZU3_RABIT/113-166             ......KLFQ..LD..TGK-RSAQRLRRGLPALLPAHRGRLLAKELEVSREAK.HHQPQFLQP----egd...........
IGF2A_XENLA/150-205              ......KSSK..YD..IWQRKSIHRLRRGVPAIVRARQYRLLMEKAEEAEQAL.SHRPLTTLPITRP..............
Q8WNP3_9MAMM/57-108              ......KFFR..DE..SWQ-KSAHRLRRGAPVQARLRRFRPLADPRHGSQ---.LFRPLGPLPGKRP..............
A4GUE9_SALSA/146-201             ......KYSK..YE..VWQRKAAQRLRRGVPAILRARKFRRQAVKIKAQEQAM.FHRPLITLPSKLP..............
Q0ZND0_9SMEG/148-203             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRRAEKIKAKEQAI.FHRPLISLPSKLP..............
IGF2_HORSE/112-166               ......KLFQ..YN..AWK-QSTQRLRRGLPALLRTRRGRMLVKELEAFREAQ.RHRPLIALPTEDP..............
Q63265_RAT/86-140                ......KFFK..FD..TWR-QSAGRLRRGLPALLRARRGRMLAKELEAFREAK.RHRPLIVLPPKDP..............
F1PBX5_CANFA/125-179             ......KFFQ..YD..TWK-QSAQRLRRGLPALLRARRGRMLAKELEAFREAK.RHRPLIALPTHDP..............
E0YC42_SALAL/146-201             ......KYSK..YE..VWQRKAAQRLRRGVPAILRARKFRRQAVKIKAQEQAM.FHRPLITLPSKLP..............
IGF2_RAT/112-166                 ......KFFK..FD..TWR-QSAGRLRRGLPALLRARRGRMLAKELEAFREAK.RHRPLIVLPPKDP..............
E0W6Z5_CANFA/116-170             ......KFFQ..YD..TWK-QSAQRLRRGLPALLRARRGRMLAKELEAFREAK.RHRPLIALPTHDP..............
A5JSG9_SPAAU/147-202             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKYRRQAEKIKAQEQAI.FHRPLISLGSKLP..............
G3HXZ9_CRIGR/87-141              ......KFFQ..YD..TWR-KSFQRLRRGLPALLRARRGRMLARELEAFREAK.RHRPLIALPPIDP..............
Q24K65_9PERO/107-162             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKYRRQAEKIKAQEQAI.FXRPLISLPSKLP..............
Q0ZNB0_9SMEG/144-199             ..rvde----..YK..EWQSNAAQRLRRGVPAILRSKKFRRQAEKIKAKEQAI.FHRPLISLPSK--la............
B6UM04_BUBBU/61-107              ......KFFH..YD..IWK-QSTQRLRRGLPAFLRARRGRTLAKELEALREAK.SHRPL--------..............
E2FKK6_SINCH/147-202             ......KYSK..YE..MWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAQEQAI.FHRPLISLPSKLP..............
Q862G1_BOVIN/82-138              ......KFFQ..YD..IWK-QSTQRLRRGLPAFLRARRGRTLAKELEALREAK.------S------xpsadrpatqdpat
G7PNW7_MACFA/129-183             ......KFFR..YD..TWK-QSTQRLRRGLPALLRARRGRMLAKELEAFREAK.RHRPLIALPTQDP..............
Q0ZNC3_9SMEG/148-203             ......KYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAKEQAI.FHRPLISLPSKLP..............
H6WS83_BOSIN/10-64               ......KFFQ..YD..IWK-QSTQRLRRGLPAFLRARRGRTLAKELEALREAK.SHRPLIALPTQDP..............
A8CG81_9PERO/147-202             ......RYSK..YE..VWQRKAAQRLRRGVPAILRAKKFRRQAEKIKAQEQAI.FHRPLISLPSKLP..............
B2ZRV8_HIPHI/138-162             ......KYSK..YE..VWQRKAAQRLRRGVPAILR------------------.-------------..............
#=GC seq_cons                    ......Ka.+..Y-..sWp.puAQRLRRGlPAlLRA++hRp.AcclcAhcpAh.hHRPLIuLPoc.P..............
//
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