GenomeNet

Database: Pfam
Entry: INSIG
LinkDB: INSIG
Original site: INSIG 
#=GF ID   INSIG
#=GF AC   PF07281.7
#=GF DE   Insulin-induced protein (INSIG)
#=GF AU   Vella Briffa B
#=GF SE   Pfam-B_17905 (release 10.0)
#=GF GA   25.20 25.20;
#=GF TC   25.50 25.30;
#=GF NC   24.80 25.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12202038
#=GF RT   Crucial step in cholesterol homeostasis: sterols promote binding
#=GF RT   of SCAP to INSIG-1, a membrane protein that facilitates
#=GF RT   retention of SREBPs in ER. 
#=GF RA   Yang T, Espenshade PJ, Wright ME, Yabe D, Gong Y, Aebersold R,
#=GF RA   Goldstein JL, Brown MS; 
#=GF RL   Cell 2002;110:489-500.
#=GF RN   [2]
#=GF RM   12242332
#=GF RT   Insig-2, a second endoplasmic reticulum protein that binds SCAP
#=GF RT   and blocks export of sterol regulatory element-binding proteins. 
#=GF RA   Yabe D, Brown MS, Goldstein JL; 
#=GF RL   Proc Natl Acad Sci U S A 2002;99:12753-12758.
#=GF DR   INTERPRO; IPR025929;
#=GF CC   This family contains a number of eukaryotic Insulin-induced
#=GF CC   proteins (INSIG-1 and INSIG-2) approximately 200 residues long.
#=GF CC   INSIG-1 and INSIG-2 are found in the endoplasmic reticulum and
#=GF CC   bind the sterol-sensing domain of SREBP cleavage-activating
#=GF CC   protein (SCAP), preventing it from escorting SREBPs to the
#=GF CC   Golgi. Their combined action permits feedback regulation of
#=GF CC   cholesterol synthesis over a wide range of sterol concentrations
#=GF CC   [1,2].
#=GF SQ   298
#=GS G2QCW9_THIHA/182-468   AC G2QCW9.1
#=GS D5GBX7_TUBMM/265-460   AC D5GBX7.1
#=GS C9SPY0_VERA1/1-209     AC C9SPY0.1
#=GS INSI1_CHICK/59-242     AC Q5ZMT9.1
#=GS E9E550_METAQ/283-401   AC E9E550.1
#=GS C7GTW0_YEAS2/99-268    AC C7GTW0.1
#=GS G0Z3C7_VULVU/28-211    AC G0Z3C7.1
#=GS F6V608_HORSE/28-211    AC F6V608.1
#=GS F9XFP1_MYCGM/1-176     AC F9XFP1.1
#=GS G9K5V8_MUSPF/28-123    AC G9K5V8.1
#=GS Q6CH05_YARLI/97-283    AC Q6CH05.1
#=GS INSI2_PAPAN/28-211     AC A9RA88.1
#=GS INS1_SCHPO/93-281      AC Q9Y7R5.1
#=GS F0XH28_GROCL/203-478   AC F0XH28.1
#=GS G1T648_RABIT/85-271    AC G1T648.1
#=GS G1M1N9_AILME/35-218    AC G1M1N9.1
#=GS F7FRI2_CALJA/1-103     AC F7FRI2.1
#=GS H0H023_9SACH/111-279   AC H0H023.1
#=GS F8MKK0_NEUT8/218-499   AC F8MKK0.1
#=GS Q8CFA5_CRIGR/28-211    AC Q8CFA5.1
#=GS G2WFK6_YEASK/99-268    AC G2WFK6.1
#=GS E1BP19_BOVIN/28-211    AC E1BP19.1
#=GS F0UIK0_AJEC8/172-435   AC F0UIK0.1
#=GS F2U6C6_SALS5/2-178     AC F2U6C6.1
#=GS C4QV83_PICPG/108-292   AC C4QV83.1
#=GS C1N570_MICPC/197-401   AC C1N570.1
#=GS H2P7D3_PONAB/28-205    AC H2P7D3.1
#=GS G1NIA2_MELGA/49-152    AC G1NIA2.2
#=GS C5PE01_COCP7/132-362   AC C5PE01.1
#=GS G9N7T2_HYPVG/171-404   AC G9N7T2.1
#=GS B5X253_SALSA/36-219    AC B5X253.1
#=GS H0GVW8_9SACH/99-272    AC H0GVW8.1
#=GS G4UNT1_NEUT9/218-499   AC G4UNT1.1
#=GS H0YQZ7_TAEGU/79-263    AC H0YQZ7.1
#=GS G3NID4_GASAC/5-188     AC G3NID4.1
#=GS G3SRK7_LOXAF/28-211    AC G3SRK7.1
#=GS F7BT53_ORNAN/66-249    AC F7BT53.1
#=GS Q4WP15_ASPFU/119-340   AC Q4WP15.1
#=GS B7GDH6_PHATC/122-292   AC B7GDH6.1
#=GS G0WCX0_NAUDC/104-255   AC G0WCX0.1
#=GS G0VI67_NAUCC/77-268    AC G0VI67.1
#=GS F5H6P3_HUMAN/20-115    AC F5H6P3.1
#=GS A2QI27_ASPNC/121-339   AC A2QI27.1
#=GS E9E550_METAQ/162-277   AC E9E550.1
#=GS G1N049_MELGA/1-131     AC G1N049.1
#=GS G7ICU6_MEDTR/545-690   AC G7ICU6.1
#=GS B8MK92_TALSN/133-340   AC B8MK92.1
#=GS H3CKD4_TETNG/26-209    AC H3CKD4.1
#=GS H2UHY6_TAKRU/32-215    AC H2UHY6.1
#=GS G0VA72_NAUCC/108-275   AC G0VA72.1
#=GS B4DQ23_HUMAN/1-103     AC B4DQ23.1
#=GS G3ID14_CRIGR/56-194    AC G3ID14.1
#=GS H0ZMV3_TAEGU/1-131     AC H0ZMV3.1
#=GS H2V9D0_TAKRU/20-203    AC H2V9D0.1
#=GS INSI1_BOVIN/83-266     AC A0JNC3.1
#=GS F6HZC0_VITVI/67-262    AC F6HZC0.1
#=GS C5DCV5_LACTC/78-257    AC C5DCV5.1
#=GS G3AQH1_SPAPN/157-318   AC G3AQH1.1
#=GS C9JSG8_HUMAN/84-123    AC C9JSG8.1
#=GS G8BVA6_TETPH/119-282   AC G8BVA6.1
#=GS INSI2_PONAB/28-211     AC Q5R687.2
#=GS B8BSU2_THAPS/26-189    AC B8BSU2.1
#=GS B8N9S0_ASPFN/128-349   AC B8N9S0.1
#=GS G3N9F3_GASAC/32-215    AC G3N9F3.1
#=GS I1GEV3_AMPQE/3-153     AC I1GEV3.1
#=GS G2WLV1_YEASK/111-297   AC G2WLV1.1
#=GS G1Q6D1_MYOLU/1-103     AC G1Q6D1.1
#=GS E7Q8D3_YEASB/112-252   AC E7Q8D3.1
#=GS G5E0W3_9PIPI/1-90      AC G5E0W3.1
#=GS B4USX1_OTOGA/28-211    AC B4USX1.1
#=GS F9G507_FUSOF/151-370   AC F9G507.1
#=GS G0Z3C5_NYCPR/28-211    AC G0Z3C5.1
#=GS I0YSB2_9CHLO/50-237    AC I0YSB2.1
#=GS A7S1I3_NEMVE/12-195    AC A7S1I3.1
#=GS E3QR22_COLGM/149-366   AC E3QR22.1
#=GS H2QIL8_PANTR/28-211    AC H2QIL8.1
#=GS E7QFP9_YEASZ/20-175    AC E7QFP9.1
#=GS Q2H703_CHAGB/195-477   AC Q2H703.1
#=GS INSI2_CALJA/28-211     AC B0CMA4.1
#=GS G8JUI6_ERECY/91-249    AC G8JUI6.1
#=GS INSI2_RAT/28-211       AC Q80UA9.1
#=GS D4D6X1_TRIVH/172-386   AC D4D6X1.1
#=GS Q4S4Y3_TETNG/58-241    AC Q4S4Y3.1
#=GS INSI1_CRIGR/64-247     AC Q8CFA6.1
#=GS H3B8S7_LATCH/30-213    AC H3B8S7.1
#=GS D2HKQ1_AILME/28-211    AC D2HKQ1.1
#=GS G1PVG6_MYOLU/86-269    AC G1PVG6.1
#=GS G4N7B0_MAGO7/198-434   AC G4N7B0.1
#=GS F6Y9H0_CALJA/84-267    AC F6Y9H0.1
#=GS INSI2_CHICK/50-153     AC Q5F3W2.1
#=GS H0GMG7_9SACH/111-297   AC H0GMG7.1
#=GS D7M474_ARALL/48-242    AC D7M474.1
#=GS A5DMZ1_PICGU/113-306   AC A5DMZ1.2
#=GS G3Y8M7_ASPNA/121-339   AC G3Y8M7.1
#=GS F6US40_MONDO/28-211    AC F6US40.1
#=GS H6BNY0_EXODN/131-351   AC H6BNY0.1
#=GS F7HBW1_MACMU/28-211    AC F7HBW1.1
#=GS Q9DFM7_GILMI/1-35      AC Q9DFM7.1
#=GS G3N9G9_GASAC/14-197    AC G3N9G9.1
#=GS C5DZL8_ZYGRC/84-264    AC C5DZL8.1
#=GS A1CH80_ASPCL/128-349   AC A1CH80.1
#=GS G1K9U7_ANOCA/28-211    AC G1K9U7.1
#=GS H2P7D4_PONAB/26-203    AC H2P7D4.1
#=GS H0VRQ7_CAVPO/61-244    AC H0VRQ7.1
#=GS E0CZ15_MOUSE/28-76     AC E0CZ15.1
#=GS C1BM65_OSMMO/25-208    AC C1BM65.1
#=GS H1VBS5_COLHI/153-370   AC H1VBS5.1
#=GS Q5I388_PIG/1-74        AC Q5I388.1
#=GS F7W133_SORMK/223-506   AC F7W133.1
#=GS E3RCG2_PYRTT/187-420   AC E3RCG2.1
#=GS G3JQS6_CORMM/179-412   AC G3JQS6.1
#=GS INSI1_RAT/66-249       AC Q08755.1
#=GS C1GA12_PARBD/172-390   AC C1GA12.1
#=GS F6K442_BUBBU/1-32      AC F6K442.1
#=GS E7KTG1_YEASL/111-297   AC E7KTG1.1
#=GS B9I9F8_POPTR/48-237    AC B9I9F8.1
#=GS B3LSP7_YEAS1/99-268    AC B3LSP7.1
#=GS E7KDH3_YEASA/100-239   AC E7KDH3.1
#=GS Q6CIB9_KLULA/73-240    AC Q6CIB9.1
#=GS INSI1_MOUSE/66-249     AC Q8BGI3.1
#=GS E3TGJ7_ICTPU/27-210    AC E3TGJ7.1
#=GS I1JBD8_SOYBN/54-247    AC I1JBD8.1
#=GS H2AP64_KAZAF/63-227    AC H2AP64.1
#=GS B5VQP8_YEAS6/111-297   AC B5VQP8.1
#=GS INSI2_HUMAN/28-211     AC Q9Y5U4.2
#=GS B9WDP4_CANDC/113-332   AC B9WDP4.1
#=GS G3WIX0_SARHA/84-267    AC G3WIX0.1
#=GS F2SGT0_TRIRC/172-386   AC F2SGT0.1
#=GS D4A242_RAT/66-249      AC D4A242.1
#=GS B6QHG7_PENMQ/127-335   AC B6QHG7.1
#=GS INSI1_DANRE/58-241     AC Q8AV61.1
#=GS H2N2V0_ORYLA/26-132    AC H2N2V0.1
#=GS F8W4P3_DANRE/1-103     AC F8W4P3.1
#=GS B2WFT2_PYRTR/187-394   AC B2WFT2.1
#=GS G1L328_AILME/1-130     AC G1L328.1
#=GS A4D2N1_HUMAN/84-149    AC A4D2N1.1
#=GS B7FIR5_MEDTR/51-238    AC B7FIR5.1
#=GS B0Y5W1_ASPFC/119-340   AC B0Y5W1.1
#=GS G1X7W0_ARTOA/155-375   AC G1X7W0.1
#=GS A6S9N8_BOTFB/109-338   AC A6S9N8.1
#=GS G8B781_CANPC/174-326   AC G8B781.1
#=GS H2N2V0_ORYLA/140-179   AC H2N2V0.1
#=GS E6ZIZ9_DICLA/58-241    AC E6ZIZ9.1
#=GS H2PP51_PONAB/84-267    AC H2PP51.1
#=GS E0CXS5_MOUSE/28-85     AC E0CXS5.1
#=GS G3RIH5_GORGO/28-211    AC G3RIH5.1
#=GS G9NND2_HYPAI/170-401   AC G9NND2.1
#=GS Q2UGK5_ASPOR/128-349   AC Q2UGK5.1
#=GS A4RSA0_OSTLU/121-338   AC A4RSA0.1
#=GS G1RI47_NOMLE/84-267    AC G1RI47.1
#=GS Q6VNB5_PIG/1-166       AC Q6VNB5.2
#=GS F2PW23_TRIEC/173-387   AC F2PW23.1
#=GS G1KKP8_ANOCA/65-248    AC G1KKP8.1
#=GS G3MWS1_BOVIN/28-211    AC G3MWS1.1
#=GS INSI1_XENLA/58-241     AC Q6DF80.1
#=GS H2AWA1_KAZAF/61-243    AC H2AWA1.1
#=GS E9D1T2_COCPS/132-362   AC E9D1T2.1
#=GS F4NY11_BATDJ/116-266   AC F4NY11.1
#=GS NSG1_YEAST/99-268      AC P38837.1
#=GS Q754M9_ASHGO/88-266    AC Q754M9.1
#=GS Q0CLJ8_ASPTN/126-344   AC Q0CLJ8.1
#=GS E7KH17_YEASA/111-272   AC E7KH17.1
#=GS G3N9F8_GASAC/57-157    AC G3N9F8.1
#=GS B6HVF3_PENCW/136-352   AC B6HVF3.1
#=GS G5BIB8_HETGA/28-211    AC G5BIB8.1
#=GS F7HBW4_MACMU/28-211    AC F7HBW4.1
#=GS H9H3E5_MACMU/84-139    AC H9H3E5.1
#=GS Q6FP81_CANGA/139-321   AC Q6FP81.1
#=GS Q01FC3_OSTTA/166-383   AC Q01FC3.1
#=GS G0RQC4_HYPJQ/186-419   AC G0RQC4.1
#=GS G2X925_VERDV/156-376   AC G2X925.1
#=GS H3HK90_STRPU/53-236    AC H3HK90.1
#=GS E3TCF3_9TELE/27-210    AC E3TCF3.1
#=GS A7EKY6_SCLS1/110-339   AC A7EKY6.1
#=GS C0S1M8_PARBP/132-350   AC C0S1M8.1
#=GS B7QLN0_IXOSC/8-191     AC B7QLN0.1
#=GS H0WWY3_OTOGA/28-211    AC H0WWY3.1
#=GS A5DXC0_LODEL/183-354   AC A5DXC0.1
#=GS Q4SWY1_TETNG/46-238    AC Q4SWY1.1
#=GS G3UB33_LOXAF/70-253    AC G3UB33.1
#=GS F6XME3_CALJA/84-267    AC F6XME3.1
#=GS H0XST0_OTOGA/76-262    AC H0XST0.1
#=GS F2RZD3_TRIT1/173-387   AC F2RZD3.1
#=GS C5FWQ9_ARTOC/150-355   AC C5FWQ9.1
#=GS G7X6S6_ASPKW/123-325   AC G7X6S6.1
#=GS A9JJB9_SCHMA/51-231    AC A9JJB9.1
#=GS A6ZT41_YEAS7/100-289   AC A6ZT41.1
#=GS G3N9G6_GASAC/27-210    AC G3N9G6.1
#=GS INSI1_HUMAN/84-267     AC O15503.3
#=GS F6Y9K5_CALJA/21-115    AC F6Y9K5.1
#=GS E7QJV4_YEASZ/111-274   AC E7QJV4.1
#=GS G8Y6E7_PICSO/127-321   AC G8Y6E7.1
#=GS G1SNI6_RABIT/28-211    AC G1SNI6.1
#=GS H3J348_STRPU/53-236    AC H3J348.1
#=GS B2KI26_RHIFE/28-211    AC B2KI26.1
#=GS D4AY09_ARTBC/172-386   AC D4AY09.1
#=GS E7KPH9_YEASL/99-268    AC E7KPH9.1
#=GS H0ZMV6_TAEGU/2-103     AC H0ZMV6.1
#=GS H0GHH4_9SACH/99-268    AC H0GHH4.1
#=GS E9C135_CAPO3/213-366   AC E9C135.1
#=GS Q5AEJ5_CANAL/115-334   AC Q5AEJ5.1
#=GS B3RT72_TRIAD/15-202    AC B3RT72.1
#=GS F1NDH8_CHICK/3-103     AC F1NDH8.1
#=GS G3UQT2_MELGA/28-211    AC G3UQT2.1
#=GS C7T5D1_9BIVA/3-191     AC C7T5D1.1
#=GS F7BYS4_HORSE/84-267    AC F7BYS4.1
#=GS D8LJ79_ECTSI/116-279   AC D8LJ79.1
#=GS H2V9C8_TAKRU/58-241    AC H2V9C8.1
#=GS G0Z3C6_VULLA/28-211    AC G0Z3C6.1
#=GS G9K5V7_MUSPF/2-185     AC G9K5V7.1
#=GS D2DXL3_PIG/28-211      AC D2DXL3.1
#=GS E4UVZ6_ARTGP/175-390   AC E4UVZ6.1
#=GS G0SFN6_CHATD/203-510   AC G0SFN6.1
#=GS D2HTZ4_AILME/944-1103  AC D2HTZ4.1
#=GS B6JWJ4_SCHJY/116-301   AC B6JWJ4.1
#=GS H9EVZ0_MACMU/84-267    AC H9EVZ0.1
#=GS G3RT31_GORGO/84-267    AC G3RT31.1
#=GS G7YNV0_CLOSI/1-140     AC G7YNV0.1
#=GS G3X2R0_SARHA/28-211    AC G3X2R0.1
#=GS C5JH58_AJEDS/169-427   AC C5JH58.1
#=GS C4JUE9_UNCRE/79-309    AC C4JUE9.1
#=GS F7H2Z8_MACMU/1-130     AC F7H2Z8.1
#=GS A1CXK5_NEOFI/119-340   AC A1CXK5.1
#=GS Q6BJN8_DEBHA/129-321   AC Q6BJN8.2
#=GS A6ZRS8_YEAS7/111-297   AC A6ZRS8.1
#=GS C4YQ48_CANAW/114-333   AC C4YQ48.1
#=GS G5AVC9_HETGA/61-244    AC G5AVC9.1
#=GS G8ZPQ7_TORDC/107-273   AC G8ZPQ7.1
#=GS B2AXP1_PODAN/179-429   AC B2AXP1.1
#=GS I1RNK1_GIBZE/152-371   AC I1RNK1.1
#=GS G1RMF4_NOMLE/28-211    AC G1RMF4.1
#=GS G1DGF2_CAPHI/28-211    AC G1DGF2.1
#=GS C8Z9S8_YEAS8/99-268    AC C8Z9S8.1
#=GS A3LUC1_PICST/149-312   AC A3LUC1.1
#=GS E7NIN1_YEASO/100-270   AC E7NIN1.1
#=GS E7Q4S8_YEASB/99-268    AC E7Q4S8.1
#=GS E1ZIZ3_CHLVA/21-194    AC E1ZIZ3.1
#=GS A6R3L5_AJECN/9-163     AC A6R3L5.1
#=GS F1NHV3_CHICK/1-131     AC F1NHV3.1
#=GS G2R9T8_THITE/188-458   AC G2R9T8.1
#=GS INSI2_PIG/28-211       AC Q6PQZ3.2
#=GS G3NIC8_GASAC/58-241    AC G3NIC8.1
#=GS G1M1N7_AILME/28-211    AC G1M1N7.1
#=GS C0NAF6_AJECG/172-435   AC C0NAF6.1
#=GS A4D2M9_HUMAN/84-267    AC A4D2M9.1
#=GS G2YX13_BOTF4/109-338   AC G2YX13.1
#=GS C4Y5U1_CLAL4/94-302    AC C4Y5U1.1
#=GS B5VK66_YEAS6/100-269   AC B5VK66.1
#=GS A1L3F8_XENLA/55-238    AC A1L3F8.1
#=GS INSI2_XENTR/21-204     AC Q5U4Q2.1
#=GS Q7SBU0_NEUCR/218-500   AC Q7SBU0.1
#=GS H3D5G0_TETNG/58-241    AC H3D5G0.1
#=GS C7YYL3_NECH7/151-376   AC C7YYL3.1
#=GS H7C5L3_HUMAN/1-176     AC H7C5L3.1
#=GS G1K3H0_XENTR/23-206    AC G1K3H0.1
#=GS Q8AV60_DANRE/24-207    AC Q8AV60.1
#=GS F2QLX7_PICP7/108-292   AC F2QLX7.1
#=GS INSI2_XENLA/21-204     AC Q66J27.1
#=GS Q5B4R5_EMENI/129-343   AC Q5B4R5.1
#=GS B9RNA1_RICCO/52-247    AC B9RNA1.1
#=GS C8ZG73_YEAS8/111-297   AC C8ZG73.1
#=GS INSI1_XENTR/58-241     AC Q0V9G6.1
#=GS F7FL01_MONDO/72-255    AC F7FL01.1
#=GS C6H4X0_AJECH/172-435   AC C6H4X0.1
#=GS E9EU22_METAR/162-301   AC E9EU22.1
#=GS G3QHP4_GORGO/84-267    AC G3QHP4.1
#=GS H2QVN6_PANTR/84-267    AC H2QVN6.1
#=GS G3U9S8_LOXAF/6-189     AC G3U9S8.1
#=GS C1GQD7_PARBA/166-384   AC C1GQD7.1
#=GS A7THJ0_VANPO/124-284   AC A7THJ0.1
#=GS E2RJ47_CANFA/44-227    AC E2RJ47.1
#=GS F7CFM3_ORNAN/69-252    AC F7CFM3.1
#=GS G3H5D0_CRIGR/28-211    AC G3H5D0.1
#=GS F1SHU4_PIG/17-200      AC F1SHU4.1
#=GS C1EJH1_MICSR/177-380   AC C1EJH1.1
#=GS C5GFU1_AJEDR/169-427   AC C5GFU1.1
#=GS NSG2_YEAST/111-297     AC P53898.1
#=GS H2M3Q1_ORYLA/58-241    AC H2M3Q1.1
#=GS Q0UXK1_PHANO/187-411   AC Q0UXK1.1
#=GS E4ZG61_LEPMJ/202-433   AC E4ZG61.1
#=GS B3LP11_YEAS1/111-297   AC B3LP11.1
#=GS G4VHB2_SCHMA/44-224    AC G4VHB2.1
#=GS C6SZ86_SOYBN/54-246    AC C6SZ86.1
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G2QCW9_THIHA/182-468              .....................................................................l-VLRAALLFVL.GVGYGVLVTRLPQ................NSH.H..Q.H.....H.P........S.R....R...L.A.A.A...Y...EShcEW.........R.YL..V.......F..W...G..V..A..GVALGSLLPWFDRF....WEERaqpssssssssssssssssssf..............scpssmaraehadadapvtskpSLTSP.P....QTDWALV.IRGIGAF.....V......GIVFAI...R.........RL.......P.........WAS..T....M...QVS........LTLALANPFL...WYLIDR.SKP....GFLLS.AAV.GLGGAA..LLMGLDPevmpaptaaaaaggggwaaavrdrl.......rgggginadnttapggavpdgagrdaAGGV.L..---.LG.GLASR.ET.IETG...IWMLSVLFCSCVCFGNIGRRLA..........................................................
D5GBX7_TUBMM/265-460              .....................................................................v-AMRGMALFAF.GVAYGAIVTDL--................HNS.K..K.F.....S.P........S.T....V...D.I.D.R...Y...NP..RY.........-.-L..V.......Q..W...G..L..A..GVVLGSLLPWLDGK...dTGNG..........................................................--SIG.A....KIDWDPA.VRSIGAF.....V......GIAYAI...R.........KL.......P.........WQS..T....L...QVS........VSLSFVNPFL...WYLIDR.TRV....GFWLS.AAV.GITGTV..FLLQTNPemiq..................................................tpetISFP.D..ESK.IA.GSVSV.ES.FGVT...VWIASVLFCSCVCFGNVGRRF-a.........................................................
C9SPY0_VERA1/1-209                ....................................................................mg-----------.---YGALVTRL--................HGK.H..Q.L.....T.A........L.P....A...D.G.T.S...G...PG.fNW.........K.YL..T.......L..W...G..I..C..GVLLGALLPWFDGV....WEEAfggdmavv..........................................dgerdetsDNANR.S....STDWALG.VRSIGAF.....V......GIVFAI...R.........RL.......P.........WAS..T....L...QLS........LTLALVNPFL...WYLIDR.SKP....GFLLS.AAV.GLIGSA..VLTGVDPemvptp.............................................sassfrnETVS.D..SLT.FG.GLASQ.KT.METG...IWMLSVLFCSCVCFGNIGRRLA..........................................................
INSI1_CHICK/59-242                .....................................................................l-VQRSVVLFVV.GAFMALVLNLLQI................QRN.V..T.L.....F.P........D.E....V...I.A.T.L...F...SS..AW.........W.VP..P.......C..C...G..T..A..AAVVGLLYPCIDSH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...A.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITI.AFVATL..ITQFLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
E9E550_METAQ/283-401              ..............................................................catdksfq-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..-.......-..-...-..-..-..--------------....----..........................................................-----.-....-------.-------.....-......------...R.........KL.......A.........WVS..T....L...QVS........ATLALVNPLL...WWLIDR.SKP....GFVLS.AAV.GLTGSI..LLLGVDPeimpapsg..........................................lptrnssnAFHS.D..PLA.LG.GLATQ.ET.VETG...VWMLSVLFCSCLCFGNIGRRL-t.........................................................
C7GTW0_YEAS2/99-268               ...............................................................ntiaaff------ILFIA.GILFPMISECLFDndqla.....kgdivsF--.-..L.K.....H.G........I.E....I...K.N.K.I...V...AE..PD.........M.VPdwA.......V..F...G..T..E..GVIFGSIVPFIDSF....VRYQh.......................................................qpKTRSSvY....KNTLGSF.IRCANTL.....L......GLIFGI...R.........KL.......E.........WSS..S....L...QAA........GAWSLLNIVL...WLFFDG.TLT....VFFPG.LVI.GALSA-..-------..........................................................----.-..---.--.-----.--.----...----------------------ftcsqcfsqlsla.............................................
G0Z3C7_VULVU/28-211               .....................................................................l-MIRGVVLFFI.GVFLALVLNLLQI................QRN.V..T.L.....F.P........P.D....V...I.A.S.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..SAVIGLLYPCIDRH....LGEP..........................................................---HK.F....KREWSSV.MRCVAVF.....V......GINHAS...A.........KV.......D.........FDN..N....I...QLS........LTLAALSIGL...WWTFDR.SRS....GFGLG.VGI.AFLATL..VTQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFAGGITMGNIGRQLA..........................................................
F6V608_HORSE/28-211               .....................................................................l-MIRGVVLFFI.GVFLALVLNLLQI................QRN.V..T.L.....F.P........P.D....V...I.A.S.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..SAVIGLLYPCIDRH....LGEP..........................................................---HK.F....KREWSSV.MRCVAVF.....V......GINHAS...A.........KV.......D.........FDN..N....I...QLS........LTLAALSIGL...WWTFDR.SRS....GFGLG.VGI.AFLATL..VTQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFAGGITMGNIGRQLA..........................................................
F9XFP1_MYCGM/1-176                ..................................................mvfgealpladvfwapdeds-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..-.......-..-...-..-..-..--------------....---Ivdd...................................................sekeQRKAR.G....TGGWQDI.VRSIGAF.....V......GLAFAI...R.........KL.......P.........WQS..T....L...QLS........LTLALVNPAL...WYLIDR.SPP....GLILS.GLV.SVGGTA..IILGINPalvpspspiellq................................ghvgkrglvngtvNALQ.D..EGH.VL.GIFSH.ET.VGVA...TWIASVLFVSAVCFGNIGRQLA..........................................................
G9K5V8_MUSPF/28-123               .....................................................................l-MIRGVVLFFI.GVFLALVLNLLQI................QRN.V..T.L.....F.P........P.D....V...I.A.S.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..SAVIGLLYPCIDRH....LGEP..........................................................---HK.F....KREWSSV.MRCVAVF.....V......GINHAS...-.........--.......-.........---..-....-...---........----------...------.---....-----.---.------..-------..........................................................----.-..---.--.-----.--.----...----------------------a.........................................................
Q6CH05_YARLI/97-283               ....................................................................pl--FKTALLFVL.GCGYGCVVHFL--................---.-..-.-.....Y.E........K.Q....V...G.T.R.R...D...TD..KL.........-.TL..P.......M..W...G..V..H..CVLLGLGLPLLDKY....KPSTsapakg.............................................lqrirakNGGSS.P....NKKWGSL.VRTVGAF.....L......GVAYGV...K.........NL.......N.........WHS..T....T...EVA........VIWALLNPFL...WYLLDT.TSN....GFGLA.AVS.SLIGAA..VMSAIGV..........................................................----.I..PVG.LG.EWAG-.--.---L...VWLASNLFCGAICFGNLGRI--id........................................................
INSI2_PAPAN/28-211                .....................................................................l-MIRGVVLFFI.GVFLALVLNLLQI................QRN.V..T.L.....F.P........P.D....V...I.A.S.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..SAVIGLLYPCIDRH....LGEP..........................................................---HK.F....KREWSSV.MRCVAVF.....V......GINHAS...A.........KV.......D.........FDN..N....I...QLS........LTLAALSIGL...WWTFDR.SRS....GFGLG.VGI.AFLATL..VTQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFAGGITMGNIGRQLA..........................................................
INS1_SCHPO/93-281                 .....................................................................f-FCKLCVIFGL.GFVFTYLAEQIVQ................DAK.L..P.L.....L.T........V.N....L...K.S.W.K...F...EP..PW.........-.-P..A.......I..F...G..F..V..AVILGLSYRRMDTKy..pLGAA..........................................................PLRPS.Q....SSKWQWI.SRYLAAF.....A......TLLLSM...K.........KL.......L.........FIS..N....S...HSI........VALVASSASI...WYIFDR.SRN....GIILS.TIT.SVLGSI..LYYNLVD..........................................................TSKI.E..LNG.VE.FPEIQ.--.--FR...LWIPMILFSASTIVGNAGRLLF..........................................................
F0XH28_GROCL/203-478              ...................................................................vfg---RAVLLFVL.GMGYGVLVSRLHSetqdrfv.dgtaasavEQD.T..A.S.....A.A........R.R....G...T.A.Y.D...A...TN..DW.........C.YL..V.......S..W...G..I..S..GVVLGLLLPWFDSL....WNRTfgidg................................................qhardKSHMA.P....ETDWALV.VRGIGAF.....A......GIALAM...R.........KL.......Q.........WAS..T....L...QAS........LTLALTNPFL...WYLLDR.SKS....GLLLA.TAV.GLVGSV..VLTALELdlmpnpgsrrddlyathcggngvyasqfngsttlssasraessssataisssastaatAAAA.A..AAA.AR.NLVSG.AT.VEMA...IWMVSVLFCSCVCFGNIGRRLA..........................................................
G1T648_RABIT/85-271               .....................................................................l-VQRSLVLFLV.GVVLALVLNLLQI................QRN.V..T.L.....F.P........E.E....V...I.A.T.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..AAVVGLLYPCIDSH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...Ah......hqKL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITV.AFLATL..ITQFLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
G1M1N9_AILME/35-218               .....................................................................l-MIRGVVLFFI.GVFLALVLNLLQI................QRN.V..T.L.....F.P........P.D....V...I.A.S.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..SAVIGLLYPCIDRH....LGEP..........................................................---HK.F....KREWSSV.MRCVAVF.....V......GINHAS...A.........KV.......D.........FDN..N....I...QLS........LTLAALSIGL...WWTFDR.SRS....GFGLG.VGI.AFLATV..VTQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFAGGITMGNIGRQLA..........................................................
F7FRI2_CALJA/1-103                ......................................................................-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..-.......-..-...-..-..-..--------------....----..........................................................-----.-....-------.MRCVAVF.....V......GINHAS...A.........KL.......D.........FDN..N....I...QLS........LTLAALSVGL...WWTFDR.SRS....GFGLG.VGI.AFLATV..VTQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFAGGITMGNIGRQLA..........................................................
H0H023_9SACH/111-279              .................................hylqavlilslsgfayhelsrnlhdnhllhpefasrp-----------.-------------................---.-..L.L.....L.G........V.K....I...C.N.W.L...S...NG..VL.........P.DW..L.......G..Y...A..V..E..GVLFGSVIPILDNI...fQTEI..........................................................VKSSA.H....HDSLTSV.IRSLNAM.....L......GVTFGI...R.........KI.......Q.........WNS..S....L...QAA........GAWGLLNVIL...WLFFDG.SIS....MLLSC.ICI.GVGCCI..-------..........................................................----.-..---.--.-----.--.----...----------------------scykditdgsqflyfm..........................................
F8MKK0_NEUT8/218-499              ....................................................................sl--LRTTLLFAL.GAGYGVLVTRL--................---.-..-.-.....-.-........P.N....G...D.S.V.T...G...GY..GW.........R.YL..T.......F..W...G..A..A..GVVLGRLLPWFDQV....WEETfgkrtrmtkkekerrraaaaaeaaaallqqapppssrtfprktpvtttlpvetdsnsgGVTSP.P....EADWPLV.VRSIGAF.....V......GIVFAI...R.........RL.......P.........WAS..T....M...QVS........ITLALANPFL...WYLIDR.SKP....GFLLS.AAV.GVTGSA..ILMGLGNpdmmpapvagagyhdhhflt.................tsgqpamdvlngttsglprsaAARM.S..GMG.GA.SSENA.AV.IETG...IWMLSVLFCSCVCFGNIGRRLA..........................................................
Q8CFA5_CRIGR/28-211               .....................................................................v-VIRGVVLFFI.GVFLALVLNLLQI................QRN.V..T.L.....F.P........P.D....V...V.T.S.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..SAVIGLLYPCIDRH....LGEP..........................................................---HK.F....KREWSSV.MRCVAVF.....V......GINHAS...A.........KV.......D.........FDN..N....F...QFS........LTLAALSVGL...WWTFDR.SRS....GFGLG.VGI.AFLATV..VTQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFAGGITMGNIGRQLA..........................................................
G2WFK6_YEASK/99-268               ...............................................................ntiaaff------ILFIA.GILFPMISECLFDndqla.....kgdivsF--.-..L.K.....H.G........I.E....I...K.N.K.I...V...AE..PD.........M.VPdwA.......V..F...G..T..E..GVIFGSIVPFIDSF....VRYQh.......................................................qpKTRSSvY....KNTLGSF.IRCANTL.....L......GLIFGI...R.........KL.......E.........WSS..S....L...QAA........GAWSLLNIVL...WLFFDG.TLT....VFFPG.LVI.GALSA-..-------..........................................................----.-..---.--.-----.--.----...----------------------ftcsqcfsqlsla.............................................
E1BP19_BOVIN/28-211               .....................................................................l-MIRGVVLFFI.GVFLALVLNLLQI................QRN.V..T.L.....F.P........P.D....V...I.A.S.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..SAVIGLLYPCIDRH....LGEP..........................................................---HK.F....KREWSSV.MRCVAVF.....V......GINHAS...A.........KV.......D.........FDN..N....I...QLS........LTLAALSIGL...WWTFDR.SRS....GFGLG.VGI.AFLATV..VTQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFAGGITMGNIGRQLA..........................................................
F0UIK0_AJEC8/172-435              .....................................................................l-LLRSALLFVF.GVVYGTIITHL--................HDN.P..R.V.....T.P........I.K....I...E.N.I.D...Vi.kRG..SW.........V.YM..V.......F..W...G..V..A..GVALGGLLPWFDVV....WEEFvegesegegvvvgaeeteggsgnvevsnrdlngsgdgsgvvrangngkvpvqvdreqlKDSGS.I....AADWNQV.VRSIGAF.....V......GIAFAI...R.........KL.......P.........WQS..T....L...QVS........LTLALVNPFL...WYLIDR.SKP....GFMLS.TAV.GLLGMV..TLLGINPdvvpgp.............................................tvnaaesAVAG.N..GSG.IL.SFASQ.ES.IAVG...TWIASVLFCSCVCFGNIGRRLA..........................................................
F2U6C6_SALS5/2-178                .....................................................................a-VLSWLVLFGC.GYVTAAVLYLLHM................EHS.V..L.I.....I.R........P.T....I...S.T.N.A...-...--..--.........-.LF..V.......A..A...G..L..T..TLFIGLLFPAVDKF....FNNK..........................................................----P.R....PQAWSLV.LRSILAL.....I......GVAIAA...V.........RF.......P.........SQR..S....H...ELN........ISLLIMASSM...WWLVDG.TAV....GLGTA.VAV.TSFGIT..ASQYLSY..........................................................----.-..-LG.VL.EWAQP.DF.FYVQ...ATLIPILFLATMSFGLLGRQLA..........................................................
C4QV83_PICPG/108-292              .................................nfklffifkniiksvahkfhfrfesneifdeysyyis-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..-.......-..N...A..T..E..GIILAVLPIFIERA....LGFSs.......................................................knSNKSR.G....SNDLGLI.MRASVSL.....V......GICFGL...R.........KL.......E.........WTS..A....F...QAS........LAWSLLNPCL...WLLLDG.TLG....GFLTS.TII.SLVSII..LSIAVGF..........................................................DDTIpK..DYS.FI.HSHDT.EA.YARV...LWVGSFVFLASIIFGKLGRY--ff........................................................
C1N570_MICPC/197-401              ..............................................................vfaretga-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...L...ES..AW.........W.VP..L.......L..F...G..G..A..GVVIGLGHTTLDGI...rLTRAakederfiaaassttkngp....................dgdaafaeekrafarrcpgAPRTS.F....EPSWPVV.FAAISVF.....A......TQYAAS...G.........VLttttppiP.........FPDlpS....R...AAD........AILFLWGLGA...WAAFDN.TKQ....GFAMA.TLT.AVAGPA..TEIVLIN..........................................................----.-..AFH.LY.AYTSP.DF.FGIP...AWIPWVYFCGSPAVGLLSR---avr.......................................................
H2P7D3_PONAB/28-205               .....................................................................l-MIRGVVLFFI.GVFLALVLNLLQI................QRN.V..T.L.....F.P........P.D....V...I.A.S.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..SAVIGLLYPCIDRH....LGEP..........................................................---HK.F....KREWSSV.MRCVAVF.....V......GINHAS...A.........KV.......D.........FDN..N....I...QLS........LTLAALSIGL...WWTFDR.SRS....GFGLG.VGI.AFLATV..VTQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFAGPLT---------tqk.......................................................
G1NIA2_MELGA/49-152               ...............................................................cnavcss-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..-.......-..-...-..-..-..--------------....----..........................................................-----.-....-------.------L.....C......GINHAS...A.........KV.......D.........FAN..N....I...QLS........LTLAALSIGL...WWTFDR.SRS....GFGLG.VGI.AFLATL..VSQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFAGGITMGNIGRQLA..........................................................
C5PE01_COCP7/132-362              ....................................................................li--RRSVLLFLF.GMAYGGIITHLHG................HPN.V..AgR.....V.P........V.N....M...E.H.I.D...L..dQR..SL.........G.YL..A.......L..W...G..V..A..GVALGSLQPWFDLL....WGDDlivgr...............................................sqnaarTAKGN.G....LLEWSPM.VRSIGAF.....V......GIAFAI...R.........KL.......P.........WQS..T....L...QVS........LTLALANPVL...WYLIDR.SKP....GFVLS.TLV.GITGML..ALLGINPtivpspatasls.................................splaatspdttmnGAPI.P..STT.NI.MGMTQ.ES.VAVG...TWIASVLFCSCVCFGNIGRRLA..........................................................
G9N7T2_HYPVG/171-404              ....................................................................la--SRALVLFVL.GAGYGVLVTHLHR................EQG.L..L.Q.....L.P........D.A....G...N.G.MpQ...Y...NG..SY.........-.-T..A.......M..W...G..FalA..GVGMGALQPWVDGE....WDGVfgcdgdeaev......................................esveslhdedEEQSL.L....ETDWALV.MRAIGVF.....V......GVAFAV...R.........RL.......S.........WTS..S....S...QVS........LAVALANLFL...WWLIDR.TMP....ALVVS.TVV.GLVGTL..FLLSVSPdmirapsttf......................................mqtnssfyaqPHAE.P..AMM.LG.GIASQ.ET.VEAG...IWILSVLFCTCLCFGNIGRRLA..........................................................
B5X253_SALSA/36-219               .....................................................................l-VIRGFMLFSI.GVFLALVLNLLQV................QRN.V..T.L.....F.P........P.D....V...I.S.S.I...F...SS..AW.........W.VA..P.......C..C...G..T..A..SAIIGLLYPCIDCR....LGEP..........................................................---HK.F....KREWSSV.MRCVAVF.....V......GINHAS...A.........KV.......D.........FAN..N....V...QLS........LTLAALSIGL...WWTFDR.SRS....GFGLG.VVI.ALLATL..STQLLVY..........................................................----.-..-NG.VF.QYTSP.DF.LYIR...SWLPCIFFAGVITMGNIGRQLA..........................................................
H0GVW8_9SACH/99-272               .........................................fvaalfilfisgilfpmiseclfdndqlv-----------.------------Kgvi.........vsflKHG.I..T.I.....K.N........R.I....V...A.E.P.D...M...VP..DW.........-.--..A.......V..F...G..T..E..GIIFGSIVPFIDSF....VRHK..........................................................RLPNT.RsiayKNTLGSF.IRCANTL.....L......GIIFGI...R.........KI.......E.........WSS..S....L...QAA........GAWSLLNIVL...WLFFDG.TLTvlfpGLAIG.VIS.SLCCAQ..-------..........................................................----.-..---.--.-----.--.----...----------------------yasqlsqtlyfid.............................................
G4UNT1_NEUT9/218-499              ....................................................................sl--LRTTLLFAL.GAGYGVLVTRL--................---.-..-.-.....-.-........P.N....G...D.S.V.T...G...GY..GW.........R.YL..T.......F..W...G..A..A..GVVLGRLLPWFDQV....WEETfgkrtrmtkkekerrraaaaaeaaaallqqapppssrtfprktpvtttlpvetdsnsgGVTSP.P....EADWPLV.VRSIGAF.....V......GIVFAI...R.........RL.......P.........WAS..T....M...QVS........ITLALANPFL...WYLIDR.SKP....GFLLS.AAV.GVTGSA..ILMGLGNpdmmpapvagagyhdhhflt.................tsgqpamdvlngttsglprsaAARM.S..GMG.GA.SSENA.AV.IETG...IWMLSVLFCSCVCFGNIGRRLA..........................................................
H0YQZ7_TAEGU/79-263               .....................................................................l-VQRSVVLFVV.GAFMALVLNLLQI................QRN.V..T.L.....F.P........D.E....V...I.S.T.L...F...SS..AW.........W.VP..P.......C..C...G..T..A..AGERGGGAECVTRA....HFQP..........................................................--TAS.D....ADIWEDA.RPALSPR.....T......VLNIFF...Q.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITI.AFVATL..ITQFLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
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Q5I388_PIG/1-74                   .....................................................................s-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..-.......-..-...-..-..-..--------------....----..........................................................-----.-....-------.-------.....-......------...-.........--.......-.........---..-....-...-VS........LTLAALSLGL...WWTFDR.SRS....GLGLG.FTI.AVLATL..ITQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGN------..........................................................
F7W133_SORMK/223-506              .....................................................................s-LLRTILLFAL.GMGYGVLVTRL--................-PN.G..D.S.....V.T........G.G....-...Y.G.W.R...Y...LT..FW.........G.AX..XxxxxxxxX..X...X..X..X..XAVLGRLLPWFDQV....WEETfgkrarvtkqekerrraaaaaea............aaalkssvsatllptetesstgeGITSP.P....EADWPLV.VRSIGAF.....V......GIVFAI...R.........RL.......P.........WTS..T....M...QVS........ITLALANPFL...WYLIDR.SKP....GFLLS.AAV.GVTGSA..ILMGLGDpdmmpapvaggmgayhdhi...................ltngqpamgvlngttsrlprDATG.R..MGG.GA.MGGAS.GN.AAVIetgIWMLSVLFCSCVCFGNIGRRLA..........................................................
E3RCG2_PYRTT/187-420              ...................................................................ilg---KLAALYAF.GVIYGIIVSHL--................HET.R..Q.L.....A.P........V.H....V...D.G.V.G...R...ES..R-.........A.YL..A.......S..W...G..L..F..GVALGSLLPYVDLV....WDAQkrtsqt..............................................dekeaeTHDSP.I....SEQINDI.VRSVAAF.....L......GIAFAI...R.........RL.......P.........WQS..T....L...QLT........LTLALVNPAL...WYILDR.SKP....GLSVSlTVT.SILTSF..IFLSNPNvlpspslppttnatq...........................vpsisdstqtqgkpstAAPV.G..QEF.FA.GMISY.ES.LAVV...TWVGSVLFCSCVCFGSIGRRLA..........................................................
G3JQS6_CORMM/179-412              .....................................................................v-VARTAVLFVL.GLGYGALVTRLHE................HEQ.A..P.P.....-.P........A.AaegpV...A.L.P.A...F...NS..T-.........-.YL..G.......A..W...G..V..A..GVVLGTLLPWFDGV....WEARfgepdaeee.......................................sagadgdnapSQVVD.T....GLDSALV.MRAIGAF.....V......GIVFAI...R.........KL.......A.........WDS..T....L...QIS........ATLALANPLL...WWLIDR.SQA....GFLLS.AAV.GLVGSL..LLLGISPdmmpaptlqll....................................rnanavngtgdDAAA.T..ATG.GP.VADGQ.-M.IETG...VWMLSVLFCSCLCFGNIGRRLF..........................................................
INSI1_RAT/66-249                  .....................................................................l-VQRSLVLFSF.GVVLALVLNLLQI................QRN.V..T.L.....F.P........D.E....V...I.A.T.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..AAVVGLLYPCIDSH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...A.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITI.AFLATL..ITQFLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
C1GA12_PARBD/172-390              .....................................................................l-LLRAVLLFAF.GVAYGTLIMHL--................HDN.H..R.L.....T.P........M.R....M...E.N.I.T...D...HG..SW.........V.YM..V.......F..W...G..L..A..GVALGGLLPWFDGV....WEEFvggecgggilk...................................egdignlnaqgdDDKQL.K....VADWNSV.VRSTGAF.....V......GIAFAI...R.........KL.......P.........WQS..T....L...QVS........LTLALVNPFL...WYLIDR.SKP....GFMLS.TAV.GLVGMV..ALLGINSdv.....................................................vpaPGVP.V..GAG.GM.QVASQ.ES.IAVG...TWIASVLFCSCVCFGNIGRRLA..........................................................
F6K442_BUBBU/1-32                 ......................................................................-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..-.......-..-...-..-..-..--------------....----..........................................................-----.-....-------.-------.....-......------...-.........--.......-.........---..-....-...---........----------...------.---....-----.---.------..-------..........................................................----.-..---.--.-YTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
E7KTG1_YEASL/111-297              ...................................hylqavlilslsgfayhelsrnlhdnhllhpdfas-----------.-------------................--R.P..L.L.....L.G........V.K....L...C.N.W.L...S...NG..VL.........P.NW..L.......G..Y...G..V..E..GLLFGSVVPILDNI...fQTEV..........................................................VKSSV.H....HDSLTSV.IRSINAM.....L......GVTFGI...R.........KI.......Q.........WNS..S....L...QAA........GAWGLLNIIL...WLFFDG.SIS....MLMSC.ICI.GVGCCI..-------..........................................................----.-..---.--.-----.--.----...----------------------scykdiidgsqflyfmdfyflgslmfgklgryly........................
B9I9F8_POPTR/48-237               ...................................................................sis-----LSLFGS.GFFLGPLIDGLHS................RVN.L..V.V.....Y.Q........NgS....I...D.I.G.P...L...HT..NI.........W.VP..P.......L..L...G..L..F..YCSVGLLQLFLDQR....APSK..........................................................--VPE.G....SPEKTAIaLVALLLF.....I......ELSAEM...Y.........RA.......G.........IAD..N....I...EAY........ILFALAE-LI...WFYLDR.TWI....GFTLA.SII.GLCC--..-------..........................................................----.-..---.--.-----.--.----...----------------------plaeipimklfhlwyypqanieilgqglvtwtttcyfvytpflislsrwlrs......
B3LSP7_YEAS1/99-268               ...............................................................ntiaaff------ILFIA.GILFPMISECLFDndqla.....kgdivsF--.-..L.K.....H.G........I.E....I...K.N.K.I...V...AE..PD.........M.VPdwA.......V..F...G..T..E..GVIFGSIVPFIDSF....VRYQh.......................................................qpKTRSSvY....KNTLGSF.IRCSNTL.....L......GLIFGI...R.........KL.......E.........WSS..S....L...QAA........GAWSLLNIVL...WLFFDG.TLT....VFFPG.LVI.GALSA-..-------..........................................................----.-..---.--.-----.--.----...----------------------ftcsqcfsqlsla.............................................
E7KDH3_YEASA/100-239              ................................................................tiaaff------ILFIA.GILFPMISECLFDndqla.....kgdivsF--.-..L.K.....H.G........I.E....I...K.N.K.I...V...AE..PD.........M.VPdwA.......V..F...G..T..E..GVIFGSIVPFIDSF....VRYQh.......................................................qpKTRSSvY....KNTLGSF.IRCSNTL.....L......GLIFGI...R.........KL.......E.........WSS..S....L...QAA........GAWSLLNIVL...WLFF--.---....-----.---.------..-------..........................................................----.-..---.--.-----.--.----...----------------------xw........................................................
Q6CIB9_KLULA/73-240               ......................valawvvlsiagiayhelsknlhdnhelhndftsrplllgatiaqsls-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.F.G...Y...LP..PW.........-.--..T.......F..Y...A..I..E..GILFGSIVPFVNWI....LGTF..........................................................---DR.Q....PTTISSV.LRSTNAM.....L......GVSFGI...R.........RI.......E.........WSS..S....L...QAS........GAWFLLNIIL...WLFFDS.SFT....MLASG.LAI.GLVTCV..TCY----..........................................................----.-..---.--.-----.--.----...----------------------qditdsaqllyfidfyf.........................................
INSI1_MOUSE/66-249                .....................................................................l-VQRSLVLFSF.GVVLALVLNLLQI................QRN.V..T.L.....F.P........D.E....V...I.A.T.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..AAVVGLLYPCIDSH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...A.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITI.AFLATL..ITQFLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
E3TGJ7_ICTPU/27-210               .....................................................................l-LIRGAMLFGV.GVFLALVLNLLQV................QRN.V..T.L.....F.P........P.D....V...I.S.S.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..SALIGLLYPCIDKR....FGEP..........................................................---HK.L....KREWSSV.MGCVAVF.....V......GINHAS...A.........KV.......D.........FAN..N....V...QLS........LTLAALSVGL...WWTFDR.SRS....GFGLG.VAI.AFLATL..TTQLLVY..........................................................----.-..-NG.VF.QYTSP.DF.LYIR...SWLPCIFFAGVITMGNIGRQLA..........................................................
I1JBD8_SOYBN/54-247               ..................................................................wasv----SLTLFGT.GFLLGPLLDGL--................HSR.V..N.L.....V.V........Y.Es.gsI...D.I.G.P...L...HT..NI.........W.VP..F.......L..L...G..L..F..YSSVGLLQLYLDEK...vLNKV..........................................................-QEAS.L....AKTIVSL.I-LLALF.....I......ELSADL...Y.........KA.......G.........ISN..N....I...EAY........ILFAAAE-FI...WFFLDR.TWL....GFTLA.CIV.GLGC--..-------..........................................................----.-..---.--.-----.--.----...----------------------plaevpimklfhlwyypqanieifgqglvtwtltcyfvytpflinlsrwlrtvy....
H2AP64_KAZAF/63-227               ..............................kivsnviifalmgniyssllanlhdykisfyrneqsnsil-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..-.......T..N...S..L..E..GIFCGLITPLIDWL....LGLN..........................................................----T.C....ENDLVKI.FRICNAM.....L......GVIFGV...R.........KI.......Q.........WTS..S....L...QGS........IAWFLLNFIL...WLFFDG.TPS....LFIIS.SFL.SYLTGL..YHYS---..........................................................----.-..---.VS.NEWSE.--.---V...IYLIDFYFLGLIIFGKIGRYL-f.........................................................
B5VQP8_YEAS6/111-297              ...................................hylqavlilslsgfayhelsrnlhdnhllhpdfas-----------.-------------................--R.P..L.L.....L.G........V.K....L...C.N.W.L...S...NG..VL.........P.NW..L.......G..Y...G..V..E..GLLFGSVVPILDNI...fQTEV..........................................................VKSSV.H....HDSLTSV.IRSINAM.....L......GVTFGI...R.........KI.......Q.........WNS..S....L...QAA........GAWGLLNIIL...WLFFDG.SIS....MLMSC.ICI.GVGCCI..-------..........................................................----.-..---.--.-----.--.----...----------------------scykdiidgsqflyfmdfyflgslmfgklgryly........................
INSI2_HUMAN/28-211                .....................................................................l-MIRGVVLFFI.GVFLALVLNLLQI................QRN.V..T.L.....F.P........P.D....V...I.A.S.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..SAVIGLLYPCIDRH....LGEP..........................................................---HK.F....KREWSSV.MRCVAVF.....V......GINHAS...A.........KV.......D.........FDN..N....I...QLS........LTLAALSIGL...WWTFDR.SRS....GFGLG.VGI.AFLATV..VTQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFAGGITMGNIGRQLA..........................................................
B9WDP4_CANDC/113-332              plkivvltlasfiynevtsqisfnhtqsnypltikhlfkissyihlddylafvgqskyghlidetfalvi-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..-.......-..-...-..-..Q..GLVMASFHPILDYY....LPKSlskrll..............................................ssnpnpSSSTS.Y....STLINDL.IRSSVAF.....L......GVSYAI...R.........NI.......E.........WSS..F....L...QVA........IIYSLVSPGL...WLLLDG.TIS....GLIGS.LVV.SIGACS..VIYYQNY..........................................................---Q.Y..LNG.VG.DVSSV.EL.VAIW...LWIGSFVFGGLIVFGKLGRFL-f.........................................................
G3WIX0_SARHA/84-267               .....................................................................l-VQRSVVLFAV.GVFLALVLNLLQI................QRN.V..T.L.....F.P........E.E....V...I.A.T.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..AAVVGLLYPCIDSH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...A.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITI.AFLATL..ITQFLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
F2SGT0_TRIRC/172-386              ....................................................................al--QQSGLLFLF.GVTFGVIIMHLHD................SPQ.M..A.AllplhI.P........V.R....V...E.I.I.N...F...GL..EW.........WhYL..V.......F..W...G..V..A..GVALGNLLPWFDLM....WEDVmg......................................................enPVKGS.S....EAGWNPM.VRSIGAF.....V......GVAFAI...R.........KL.......P.........WQS..S....T...QVC........LTLALVNPFL...WYLIDR.SKS....GFVLS.TAI.GLIGMM..ALLEMNPdiifsp.............................................snatdavD--E.T..VFG.IAgLTLSQ.GQ.LAVG...TWIASVLFCSCVCFGNIGRKLA..........................................................
D4A242_RAT/66-249                 .....................................................................l-VQRSLVLFSF.GVVLALVLNLLQI................QRN.V..T.L.....F.P........D.E....V...I.A.T.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..AAVVGLLYPCIDSH....LGEP..........................................................---HK.F....KREWASV.MRCIGVF.....V......GINHAS...A.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SLS....GLGLG.ITI.AFLATL..ITQFLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLLCIFFSGGVTVGNIGRQLA..........................................................
B6QHG7_PENMQ/127-335              .....................................................................l-VLKTSLLFIC.GVTYGTIIAHL--................HEN.N..W.I.....A.P........V.K....L...E.Y.I.D...-...RN..SY.........V.YL..L.......A..W...G..I..A..GVAFAFVLPWLDKL....GDNDta.....................................................dqnKDVEN.K....QSTVTLA.IRSIGAF.....V......GIAFAM...R.........RL.......P.........WES..A....T...QES........VTLALVNPLL...WYLIDR.TRT....GFWLS.TVV.AIVGMG..ITLGLHPelipsss............................................stvglglRNWR.L..EYD.IE.GGISQ.DA.TAVA...VWLASVFYSACVCFGNIGRQL-t.........................................................
INSI1_DANRE/58-241                ....................................................................li--RRGLVLFIV.GVVLALVLNLLQI................QRN.V..T.L.....F.P........E.E....V...L.D.T.L...F...SS..AW.........W.IP..L.......C..C...G..T..A..AAVVGLLYPCLDHH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...A.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GFGLG.LTT.ALLATL..IAQLLVY..........................................................----.-..-NG.IY.QYTSP.DF.LYVR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
H2N2V0_ORYLA/26-132               .....................................................................l-LIRGGLLFSV.GVFLALVLNLLQV................QRN.V..T.L.....F.P........P.D....V...I.S.S.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..SGVYGRVRGCFRSS....SGVP..........................................................-----.-....-------.-------.....-......------...-.........--.......-.........---..-....-...---........----------...------.---....-----.---.------..-------..........................................................----.-..---.--.-----.--.----...----------------------arhlmgsqvgirmapsslevgggfkmlesrhwgalk......................
F8W4P3_DANRE/1-103                ......................................................................-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..-.......-..-...-..-..-..--------------....----..........................................................-----.-....-------.MRCIAVF.....V......GINHAS...A.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GFGLG.LTT.ALLATL..IAQLLVY..........................................................----.-..-NG.IY.QYTSP.DF.LYVR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
B2WFT2_PYRTR/187-394              ...................................................................ilg---KLAALYAF.GVIYGIIVSHL--................HET.R..Q.L.....A.P........V.H....V...D.G.V.G...R...ES..R-.........T.YL..A.......S..W...G..L..F..GVALGSLLPYVDLV....WDVQkrasqt..............................................dekeveTHDSP.I....SEQINDV.VRSVAAF.....L......GIAFAI...-.........--.......-.........--S..T....L...QLT........LTLALVNPAL...WYILDR.SKP....GLSVSlTVT.SILTSF..IFL----..........................................................----.-..---.--.-----.--.----...----------------------snpnvlpspslppttnatqvpsmsdsthmqgrpstvapmgqeffagmisyeslavvtw
G1L328_AILME/1-130                ......................................................................-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..-.......-..-...-..-..-..-AVVGLLYPCIDSR....LGEP..........................................................---HK.F....KREWASV.MRCVAVF.....V......GINHAS...A.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITV.AFLATV..ITQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
A4D2N1_HUMAN/84-149               .....................................................................l-LQRSLVLFSV.GVVLALVLNLLQI................QRN.V..T.L.....F.P........E.E....V...I.A.T.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..AGI-----------....----..........................................................-----.-....-------.-------.....-......------...-.........--.......-.........---..-....-...---........----------...------.---....-----.---.------..-------..........................................................----.-..---.--.-----.--.----...----------------------hpqissifvl................................................
B7FIR5_MEDTR/51-238               ...................................................................rvs-----LSLFGA.GFVLGPLLDGL--................HSR.V..E.L.....V.A........Y.K....S...G.A.I.DigpL...HT..NI.........W.VP..P.......L..L...G..L..F..YCSVGLLQLYLDER...vLNKV..........................................................-QDGS.L....TKTISSL.I-LVALF.....I......ELSAEL...Y.........KA.......G.........IAD..N....I...VAY........ILFAAAE-FL...WFSLNG.TWP....GFTLS.CIV.GFACPL..-------..........................................................----.-..---.--.-----.--.----...----------------------aeiplmkflhlwyypqanieifgqglvtwtltcyfvytlflinlsrwf..........
B0Y5W1_ASPFC/119-340              ......................................................................QVFRSVLLFGF.GVAYGVITVHL--................HEN.H..W.I.....T.P........V.K....L...E.N.I.R...Y...YD..SW.........Q.YL..G.......L..W...G..L..A..GVALGNVLPWLDSF....AGEWntdrsqt............................................vkgqennRLRED.R....TPAWVIV.ARSVGAF.....V......GIAFAL...R.........RL.......P.........WES..T....T...QAS........ATLALVNPVL...WYLIDR.TKA....GFLLS.TVV.GLAGTG..VVLGLKPelvpasad.........................................tpattipllNGTV.L..EYG.LP.TGLTQ.EG.VSVR...IWLASVLFCACVCFGNVGRQLA..........................................................
G1X7W0_ARTOA/155-375              ..................................................................qigi----LIVLFSA.GASYGFIISQL--................HDQ.S..H.I.....A.P........V.K....V...Q.V.E.R...D...TV..G-.........-.YL..V.......S..W...G..I..A..AVVLGSLLPWVDGI....WEDYvwesgsd...........................................eddgksggEERGE.V....TPGWNPA.VRSIGAF.....V......GVAYAI...R.........KL.......P.........WQS..T....S...QAT........LTLASANPVL...WYILDR.TRT....GFWLS.TIV.AVFGSM..FLIGFNPdfvaipsdd........................................gvgiieklrNLAV.T..GHG.GA.ELQM-.KF.WGAT...TWIASVLYVSCLCFGNLGRR--vw........................................................
A6S9N8_BOTFB/109-338              .....................................................................r-VFRSVLLFGL.GLLYGLLVKHL--................HDD.R..H.L.....A.P........L.Q....V...E.T.IiK...P...SH..DW.........K.YL..V.......F..W...G..I..A..GVGLGSVLPLVDKF....WEERvqlpfesstc......................................tpseeaidvsNSQGV.L....GGDWILA.VRSVGAF.....V......GIAYAI...R.........KL.......P.........WAS..D....M...QAS........LALALVNPVL...WYLIDR.SKP....GLAFS.AAV.GATGSV..LLLASNSdlmpspaas........................................mknntvshqPADY.S..EAE.SE.KLVTR.GN.LEAG...IWIASVLFCSCVCFGNIGRRLA..........................................................
G8B781_CANPC/174-326              ..............................................................eilaltlq-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..-.......-..-...-..-..-..GLLMASLHPILDKL....LPKFfskr.................................................llssnPNPSS.K....SNVSSDL.IRSGITF.....L......GISYAI...R.........KI.......E.........WSS..F....L...QVS........IIWSLINPGL...WLLLDG.TIS....GFLAS.LVA.STVACV..SIYSSNH..........................................................----.Q..FIN.GY.SKTTD.DV.IALW...LWVGSFFFCGIIIFGKLGRGL-f.........................................................
H2N2V0_ORYLA/140-179              ...............................................................edaplsl-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..-.......-..-...-..-..-..--------------....----..........................................................-----.-....-------.-------.....-......------...-.........--.......-.........---..-....-...---........----------...------.---....-----.---.------..-------..........................................................----.-..---.--.RYTSP.DF.LYIR...SWLPCIFFAGVITMGNIGRQLA..........................................................
E6ZIZ9_DICLA/58-241               ....................................................................li--RRGLVLFTV.GAFLALVLNLLQI................QRN.V..T.L.....F.P........E.E....V...M.T.T.L...F...SS..AW.........W.IP..P.......C..C...G..T..G..AAVVGLLYPCLDSH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...V.........KL.......N.........IDN..T....V...QLS........LTLAALSLGL...WWTFDR.SRS....GFGLG.ITT.AFLATV..FTQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
H2PP51_PONAB/84-267               .....................................................................l-VQRSLVLFSV.GVVLALVLNLLQI................QRN.V..T.L.....F.P........E.E....V...I.A.T.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..AAVVGLLYPCIDSH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...A.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITI.AFLATL..ITQFLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
E0CXS5_MOUSE/28-85                .....................................................................v-VIRGVVLFFI.GVFLALVLNLLQI................QRN.V..T.L.....F.P........P.D....V...I.T.S.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..S-------------....----..........................................................-----.-....-------.-------.....-......------...-.........--.......-.........---..-....-...---........----------...------.---....-----.---.------..-------..........................................................----.-..---.--.-----.--.----...----------------------dthl......................................................
G3RIH5_GORGO/28-211               .....................................................................l-MIRGVVLFFI.GVFLALVLNLLQI................QRN.V..T.L.....F.P........P.D....V...I.A.S.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..SAVIGLLYPCIDRH....LGEP..........................................................---HK.F....KREWSSV.MRCVAVF.....V......GINHAS...A.........KV.......D.........FDN..N....I...QLS........LTLAALSIGL...WWTFDR.SRS....GFGLG.VGI.AFLATV..VTQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFAGGITMGNIGRQLA..........................................................
G9NND2_HYPAI/170-401              .....................................................................l-VSRAVVLFVL.GAGYGVLVTHLHQ................EPQ.L..LqL.....T.E........A.S....S...A.V.P.R...Y...NG..SY.........L.AL..W.......G..F...G..L..T..GVALGALQPWFDGL....WDGLfgadeqavv........................................epaeplsdtTKATA.S....ETDWALV.VRAVGVF.....V......GVAFAV...R.........RL.......A.........WSS..S....M...QLS........VAVALASFVL...WWLIDR.SVS....ALILS.AGV.GLAGSV..LVWGVNPdmipapaaqn......................................issngipsmaSYTD.L..TTA.LN.SIASH.ET.IEAS...IWIVSVLFCTCLCFGNIGRRLA..........................................................
Q2UGK5_ASPOR/128-349              ......................................................................QALKAALLFSF.GIVYGIITIHL--................HEN.H..W.I.....T.P........V.K....L...E.N.T.H...Y...YG..SW.........E.YL..G.......F..W...G..V..A..GVVLGNVLPGLDLF....SEDVtvdyakq............................................psrssndEENEE.R....TLSWVAA.VRSVGAF.....V......GVAFAM...R.........RT.......P.........WQS..T....T...QAS........ATLALANPVL...WYLIDR.TRT....GFFMS.TIV.GVGGMG..IVLALRPdlvppstg.........................................asasaipalNSTL.R..DLG.FG.TGITQ.ES.LAVR...TWVASVLFSACVCFGNIGRQLA..........................................................
A4RSA0_OSTLU/121-338              ..............................................fgpimnfiapepvkdlfrimfvne-----------.-------------................---.-..-.-.....-.-........-.-....-...-.N.G.V...L...ET..GW.........W.VP..P.......L..F...G..A..A..AIVIGLGHTSLDEF....RIRSsvkrareieirkglqg.........................teqivsrtselienakgKPALG.W....QPSWVSV.NLCISVFafqylV......SGILAS...P.........QS.......P.........FVD..GflpyH...LID........IFLCVWAVTT...WYFFDN.SAQ....GLFMA.SLT.AVCGPV..AEIVLIN..........................................................----.-..YGH.LY.SYSHP.DI.LGIP...TWIPWVYFCGGPAVGNLSRQV-r.........................................................
G1RI47_NOMLE/84-267               .....................................................................l-VQRSLVLFSV.GVVLALVLNLLQI................QRN.V..T.L.....F.P........E.E....V...I.A.T.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..AAVVGLLYPCIDSH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...A.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITI.AFLATL..ITQFLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
Q6VNB5_PIG/1-166                  .....................................................................l-----------.--------NLLQI................QRN.V..T.L.....F.P........E.E....V...I.A.T.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..AAVVGLLYPCIDSH....LGEP..........................................................---HK.F....KREWASV.MRCVAVF.....V......GINHAS...A.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.LTI.AVLATL..ITQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
F2PW23_TRIEC/173-387              ....................................................................al--QQSGLLFLF.GVTFGVIIMHLHD................SPQ.M..A.AllplhI.P........V.R....V...E.I.I.N...F...GL..EW.........WhYL..V.......F..W...G..V..A..GVALGNLLPWFDLMwedfMGEN..........................................................PVKGS.S....EAGWNPM.VRSIGAF.....V......GVAFAI...R.........KL.......P.........WQS..S....T...QVC........LTLALVNPFL...WYLIDR.SKS....GFVLS.TAI.GLTGMM..ALLEMNPdiifsps............................................naadavdETVF.G..IAG.L-.-TLSQ.SQ.LAVG...TWIASVLFCSCVCFGNIGRKLA..........................................................
G1KKP8_ANOCA/65-248               .....................................................................v-VQRSLVLFTV.GTFLALVLNLLQI................QRN.V..T.L.....F.P........E.E....V...I.D.T.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..AAVIGLLYPCIDSH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...A.........KL.......D.........FAN..N....I...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITI.AFVATL..ITQFLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
G3MWS1_BOVIN/28-211               .....................................................................l-MIRGVVLFFI.GVFLALVLNLLQI................QRN.V..T.L.....F.P........P.D....V...I.A.S.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..SAVIGLLYPCIDRH....LGEP..........................................................---HK.F....KREWSSV.MRCVAVF.....V......GINHAS...A.........KV.......D.........FDN..N....I...QLS........LTLAALSIGL...WWTFDR.SRS....GFGLG.VGI.AFLATV..VTQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFAGGITMGNIGRQLA..........................................................
INSI1_XENLA/58-241                .....................................................................l-IQRSLVLFTV.GVFLALVLNLLQI................QRN.V..T.L.....F.P........E.E....V...I.A.T.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..AAVVGLLYPCIDSR....IGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...A.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITI.AFLATL..ITQFLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
H2AWA1_KAZAF/61-243               ....................................................................vi--FAGLVLFCL.GVVFAIISEEIYDnc...........sltNGV.L..S.I.....T.L........N.K....I...N.T.W.M...N...EY..VT.........G.TP..K.......CvtY...G..I..L..GVLCGFVIPIVDNI....LNID..........................................................-KRQI.K....NNDFNSI.LKCLNAM.....L......GICLGI...R.........NI.......E.........WSS..S....L...QAS........VAWCLLNIIL...WLFLDG.TES....IALVG.IVI.SLTSCV..ISFQ---..........................................................----.-..---.--.-----.--.----...----------------------qlfdvteiiyivdfyffsflvfgkmgrylf............................
E9D1T2_COCPS/132-362              ....................................................................li--RRSVLLFLF.GMAYGGIITHLHG................HPN.V..AgR.....V.P........V.N....M...E.H.I.D...L..dQR..SL.........G.YL..A.......L..W...G..V..A..GVALGSLQPWFDLL....WGDDlivgr...............................................sqnaarTAKGN.G....LLEWSPM.VRSIGAF.....V......GIAFAI...R.........KL.......P.........WQS..T....L...QVS........LTLALANPVL...WYLIDR.SKP....GFVLS.TLV.GITGML..ALLGINPtivpspatasls.................................splaatspdttmnGAPI.P..STT.NI.MGMTQ.ES.VAVG...TWIASVLFCSCVCFGNIGRRLA..........................................................
F4NY11_BATDJ/116-266              ...................................................................sgs-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.L...F...ST..AG.........W.VP..L.......S..C...G..L..S..ACLMGTLYPLLDQW....LLSR..........................................................QQVLG.V....RRDWSSA.LRCCGGF.....I......GISYAA...S.........KL.......T.........LAS..S....I...HMS........VTLALLALGL...WYLFDR.TIH....GFVVS.FIG.AAIGTL..VVSMLVQ..........................................................----.-..-NG.VY.SFTQA.DL.FGVR...SWVPCILYTACICIGSIGRLL-..........................................................
NSG1_YEAST/99-268                 ...............................................................ntiaaff------ILFIA.GILFPMISECLFDndqla.....kgdivsF--.-..L.K.....H.G........I.E....I...K.N.K.I...V...AE..PD.........M.VPdwA.......V..F...G..T..E..GVIFGSIVPFIDSF....VRYQh.......................................................qpKTRSSvY....KNTLGSF.IRCANTL.....L......GLIFGI...R.........KL.......E.........WSS..S....L...QAA........GAWSLLNIVL...WLFFDG.TLT....VFFPG.LVI.GALSA-..-------..........................................................----.-..---.--.-----.--.----...----------------------ftcsqcfsqlsla.............................................
Q754M9_ASHGO/88-266               ...................................................................hlv---SSLVILGIsGIAYHQLSRNLHDnd............llHED.F..T.S.....R.P........L.V....L...G.V.K.L...C...QQ.lSF.........G.ML..P.......T..W..aGyaV..E..GILFGSLLPAVDYW....RRI-..........................................................---SV.G....KVNLSGV.LRSINAM.....L......GVSFGI...R.........RV.......E.........WSS..S....L...QAS........GAWFLLDGIL...WLFFDG.SFS....VFLLG.FAV.GLVTAV..TCY----..........................................................----.-..---.--.-----.--.----...----------------------eeitdfsqllyfidfyflgllffgrlgr..............................
Q0CLJ8_ASPTN/126-344              ......................................................................QTLKSALLFGF.GVVYGIITIHL--................HEN.H..W.I.....T.P........V.K....L...E.N.T.H...F...YG..SL.........E.YL..G.......L..W...G..I..A..GVALGNVLPWLDTF....SEDGgvdds...............................................kasrneEETEE.R....TRSWVAA.VRSVGAF.....V......GVAFAM...R.........RT.......P.........WAS..T....T...QAS........ATLALTNPVL...WYLIDR.TIT....GFVMS.TVV.GVAGMG..ILLKLWPelvpasan.........................................gtpavppllNGTL.W..DYG.LA.TGFTQ.ES.IAVR...TFVASVLFSACVCFGNIGRQLA..........................................................
E7KH17_YEASA/111-272              ....................................hylqavlilslsgfayhelsrnlhdnhllhpdfa-----------.-------------................-SR.P..L.L.....L.G........V.K....L...C.N.W.L...S...NG..VL.........P.NW..L.......G..Y...G..V..E..GLLFGSVVPILDNI...fQTEV..........................................................VKSSV.H....HDSLTSV.IRSINAM.....L......GVTFGI...R.........KI.......Q.........WNS..S....L...QAA........GAWGLLNIIL...WLFFDG.SIS....MLMSC.ICI.GVGCCI..-------..........................................................----.-..---.--.-----.--.----...----------------------scykdiidg.................................................
G3N9F8_GASAC/57-157               ................................................................clyrcq-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..-.......-..-...-..-..-..--------------....----..........................................................-----.-....-------.-------.....-......SINHAS...A.........KV.......D.........FAN..N....V...QLS........LTLAALSVGL...WWTFDR.SRS....GFGLG.VSI.ALLATL..ATQLLVY..........................................................----.-..-NG.VF.QYTSP.DF.LYIR...SWLPCIFFAGVITMGNIGRQLA..........................................................
B6HVF3_PENCW/136-352              ......................................................................QALSSVLLFGF.GLAYGVITVHL--................HDN.H..W.I.....T.P........V.K....L...E.N.I.H...Y...YD..SW.........Q.YL..G.......F..W...G..L..A..GIALGNLLPWLDSC....REGDsdskl................................................agtneEDSED.R....TPSWVTV.ARSVGAF.....V......GIAFAM...R.........RL.......P.........WES..T....T...QAS........LTLALANPVL...WYLIDR.TTT....GFVLS.TTV.GLAGMG..VVLGLKPelvpistg..........................................psfgttllNGTG.L..ENV.LG.AGITQ.ES.IAVG...TWIASVIFCACVCFGNVGRQLA..........................................................
G5BIB8_HETGA/28-211               .....................................................................l-VIRGVVLFFI.GVFLALVLNLLQI................QRN.V..T.L.....F.P........P.D....V...I.A.S.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..SAVIGLLYPCIDRH....LGEP..........................................................---HK.F....KREWSSV.MRCVAVF.....V......GINHAS...A.........KV.......D.........FDN..N....I...QLS........LTLAALSIGL...WWSFDR.SRS....GFGLG.VGI.AFLATV..VTQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFAGGITMGNIGRQLA..........................................................
F7HBW4_MACMU/28-211               .....................................................................l-MIRGVVLFFI.GVFLALVLNLLQI................QRN.V..T.L.....F.P........P.D....V...I.A.S.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..SAVIGLLYPCIDRH....LGEP..........................................................---HK.F....KREWSSV.MRCVAVF.....V......GINHAS...A.........KV.......D.........FDN..N....I...QLS........LTLAALSIGL...WWTFDR.SRS....GFGLG.VGI.AFLATL..VTQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFAGGITMGNIGRQLA..........................................................
H9H3E5_MACMU/84-139               .....................................................................l-VQRSLVLFSV.GVVLALVLNLLQI................QRN.V..T.L.....F.P........E.E....V...I.A.T.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..A-------------....----..........................................................-----.-....-------.-------.....-......------...-.........--.......-.........---..-....-...---........----------...------.---....-----.---.------..-------..........................................................----.-..---.--.-----.--.----...----------------------ge........................................................
Q6FP81_CANGA/139-321              ..................fvfaivvlsisgvayhqlsrnlhdnhllhedfasrpllwgvtiqqklscgil-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.-P..D.......W..F...G..Y..AleGIIFGSIIPLMDHI....TKVK..........................................................-LR-P.T....SYSLSSV.IRSINAM.....L......GVTFGI...R.........KI.......Q.........WAS..S....G...QAA........GAWGLLNVIL...WLFFDG.TLS....MFSNC.SVL.GLLC--..-------..........................................................----.-..---.--.-----.--.----...----------------------cascfheitdvsqflyfmdfyflgslmfgkigryly......................
Q01FC3_OSTTA/166-383              ..............................................fgrmfdsvlpgfikdavrvafvne-----------.-------------................---.-..-.-.....-.-........-.-....-...-.N.G.V...L...ET..GW.........W.VP..P.......L..F...G..V..A..AIVIGTGTTILDERr..iRDSVrrareteirrgmhgi...........................deqvsrtsdlidrcpgKPALG.F....MPGWMSV.NWCISVF.....A......FQYLAS...G.........VL.......AspqsplvdgFLP..Y....H...LID........FVLCVWGVST...WYIFDR.SAQ....GFFMA.SLT.AVAGPV..AEIVLIN..........................................................----.-..YGH.LY.SYAHP.DV.LGIP...TWIPWVYFCGAPAVGNLSRQL-r.........................................................
G0RQC4_HYPJQ/186-419              ....................................................................la--SRALVLFVL.GAGYGVLVTHLHQ................EQG.L..L.Q.....L.S.......dA.G....T...G.M.P.R...Y...NG..SY.........-.-T..A.......M..W...G..FalA..GVAMGALQPWVDGE....WDRIfgrqqdqep........................................eadsdeslpDDAAK.L....ETDWTLI.MRAVGVF.....A......GVAFAV...R.........RL.......A.........WTS..S....T...QVS........VAMALVNIFL...WWLIDR.TMA....ALVVS.TIV.GAAGTL..FLLSVSPdvirapsttlv....................................tqthnvssaepSAEP.A..ATI.LG.GIASP.ET.VEAG...IWILSVLFCTCLCFGNIGRRLA..........................................................
G2X925_VERDV/156-376              ....................................................................vt--ARVAVLFLL.GMGYGALVTRL--................HGK.H..H.L.....A.A........L.P....A...D.E.T.S...G..pGF..NW.........K.YL..T.......L..W...G..I..C..GVLLGALLPWFDGV....WEEAfggdmavv..........................................dggrdetsDNASR.S....STDWALG.VRSIGAF.....V......GIVFAI...R.........RL.......P.........WAS..T....L...QLS........LTLALVNPFL...WYLIDR.SKP....GFLLS.AAV.GLIGSA..VLMGVDPemvptp.............................................sassfrnETVS.D..SLT.FG.GLASQ.KT.METG...IWMLSVLFCSCVCFGNIGRRLA..........................................................
H3HK90_STRPU/53-236               ....................................................................lc--RRGVVLFLI.GIVMALVLNLLQV................QNN.V..T.L.....F.P........P.E....T...L.D.S.I...S...SS..AW.........W.VA..P.......F..C...G..S..A..AVLVGLLYPCIDDK....LGET..........................................................---PY.Y....KREWSHV.MRCLAVF.....V......GINHAC...A.........KI.......E.........FAN..N....L...QFS........LTLAAMSLGL...WWLFDR.SRS....GFGLA.LTI.AFLATL..ITQLLVY..........................................................----.-..-KG.VY.RYTEP.DF.LYVR...SWLPCVFFSGGVTIGNIGRQLA..........................................................
E3TCF3_9TELE/27-210               .....................................................................l-LIRGAMLFGV.GVFLALVLNLLQV................QRN.V..T.L.....F.P........P.D....V...I.S.S.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..SALIGLLYPCIDKR....FGEP..........................................................---HK.L....KREWSSV.MRCVAVF.....V......GINHAS...A.........KV.......D.........FAN..N....V...QLS........LTLAALSVGL...WWTFDR.SRS....GFGLG.VAI.AFLATL..TTQLLVY..........................................................----.-..-NG.VF.QYTSP.DF.LYIR...SWLPCIFFAGVITMGNIGRQLA..........................................................
A7EKY6_SCLS1/110-339              .....................................................................r-IFRSILLFGL.GVLYGLLVKHL--................HDD.R..H.L.....A.P........L.Q....V...E.S.IiK...P...SH..DW.........R.YL..V.......F..W...G..I..A..GVGLGSLLPLVDKL....WEEKirspqgtsts......................................tsseeaidvsDSQSI.L....GEDWILA.VRSVGAF.....V......GIAFAI...R.........KL.......P.........WAS..D....M...QAS........LTLALVNPVL...WYIIDR.SKP....GLVFS.AAI.GATGSA..ILLASNSdlmpspaaa........................................vknstvshhPIDY.S..EAG.SE.NSMAR.GN.LEAG...IWISSVLFCSCVCFGNIGRRLA..........................................................
C0S1M8_PARBP/132-350              .....................................................................l-LLRAVLLFAF.GVAYGTLIMHL--................HDN.H..R.L.....T.P........M.R....M...E.N.I.T...D...HG..SW.........V.YM..V.......F..W...G..L..A..GVALGGLLPWFDGV....WEEFvggecgggilk...................................egdignlnaqgdDDKQL.K....VADWNSV.VRSTGAF.....V......GIAFAI...R.........KL.......P.........WQS..T....L...QVS........LTLALVNPFL...WYLIDR.SKP....GFMLS.TAV.GLVGMV..ALLGINSdv.....................................................vpaPGVP.V..GAG.GM.QVASQ.ES.IAVG...TWIASVLFCSCVCFGNIGRRLA..........................................................
B7QLN0_IXOSC/8-191                ....................................................................ll--WRVAFLFLV.GVFFSLMLDFFQI................QYR.L..S.A.....F.E........R.N....L...I.G.S.M...F..mSS..PW.........W.VP..A.......I..C...G..T..A..AVSVGLLYPCVDHK....LGEE..........................................................----T.I....PHRWSDV.MKCIALF.....V......GINQAS...A.........KI.......E.........LQS..D....W...QPS........LSLVLLSVSL...WWLCDR.THS....GFGLS.ILT.ALIATL..VAHFLVY..........................................................----.-..-YR.IG.RCSDK.DL.TFVR...SWLPCVFFSGGITVGNIGRLLA..........................................................
H0WWY3_OTOGA/28-211               .....................................................................l-MIRGVVLFFI.GVFLALVLNLLQI................QRN.V..T.L.....F.P........P.D....V...I.A.S.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..SAVIGLLYPCIDRH....LGEP..........................................................---HK.F....KREWSSV.MRCVAVF.....V......GINHAS...A.........KV.......D.........FDN..N....I...QLS........LTLAALSIGL...WWTFDR.SRS....GFGLG.VGI.AFLATV..VTQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFAGGITMGNIGRQLA..........................................................
A5DXC0_LODEL/183-354              ......gifaltlqgllmaslhpifdrllpkiftkrllssnpiqsasstsstlstsstssstslsntnfm-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..-.......-..-...-..-..-..--------------....----..........................................................-----.-....----NDL.IRTCITF.....L......GISYAI...R.........KI.......E.........WSS..F....L...QVS........IIWSLINPGL...WLLLDG.TIS....GFLSS.LLV.TALCCI..IIYLQNT..........................................................----.H..IIT.SY.SKTTN.DV.IALW...LWIGSFFFCGIIIFGKIGRGL-f.........................................................
Q4SWY1_TETNG/46-238               .....................................................................l-LIRGAMLFSV.GVFLALVLNLLQV................QRN.V..T.L.....F.P........P.D....V...L.S.S.I...F...SS..AW.........W.VP..P.......C..C...G..S..A..SAIIGLLYPCIDRR....LGEP..........................................................---HR.F....KREWSSV.MRCVAVF.....V......GINHAS...AvsflpgqseKV.......D.........FAN..N....V...QLS........LTLAALSVGL...WWTFDR.SRS....GFGLG.VSI.ALLATL..ATQLLVY..........................................................----.-..-NG.VF.QYTSP.DF.LYIR...SWLPCIFFAGVITMGNIGRQLA..........................................................
G3UB33_LOXAF/70-253               .....................................................................l-VQRSLVLFSV.GVVLALVLNLLQI................QRN.V..T.L.....F.P........D.E....V...I.A.T.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..AAVVGLLYPCIDSH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...A.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITI.AFLATL..ITQFLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
F6XME3_CALJA/84-267               .....................................................................l-VQRSLVLFSV.GVVLALVLNLLQI................QRN.V..T.L.....F.P........E.E....V...I.A.T.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..AAVVGLLYPCIDSH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...A.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITI.AFLATL..ITQFLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
H0XST0_OTOGA/76-262               .....................................................................l-VQRSLVLFLV.GVVLALVLNLLQI................QRN.V..T.L.....F.P........E.E....V...I.A.T.V...F...SS..AW.........W.VP..P.......C..C...G..T..A..AAVVGVLYPCIDSH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...Av......slKL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITI.AFLATL..ITQFLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
F2RZD3_TRIT1/173-387              ....................................................................al--QQSGLLFLF.GVTFGVIIMHLHD................SPQ.M..A.AllplhI.P........V.R....V...E.I.I.N...F...GL..EW.........WhYL..V.......F..W...G..V..A..GVALGNLLPWFDLMwedfMGEN..........................................................PVKGS.S....EAGWNPM.VRSIGAF.....V......GVAFAI...R.........KL.......P.........WQS..S....T...QVC........LTLALVNPFL...WYLIDR.SKS....GFVLS.TAI.GLTGMM..ALLEMNPdiifsps............................................naadavdETVF.G..IAG.L-.-TLSQ.SQ.LAVG...TWIASVLFCSCVCFGNIGRKLA..........................................................
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E7QJV4_YEASZ/111-274              ....................................hylqavlilslsgfayhelsrnlhdnhllhpdfa-----------.-------------................-SR.P..L.L.....L.G........V.K....L...C.N.W.L...S...NG..VL.........P.NW..L.......G..Y...G..V..E..GLLFGSVVPILDNI...fQTEV..........................................................VKSSV.H....HDSLTSV.IRSINAM.....L......GVTFGI...R.........KI.......Q.........WNS..S....L...QAA........GAWGLLNIIL...WLFFDG.SIS....MLMSC.ICI.GVGCCI..-------..........................................................----.-..---.--.-----.--.----...----------------------scykdiidgsq...............................................
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H3J348_STRPU/53-236               ....................................................................lc--RRGVVLFLI.GIVMALVLNLLQV................QNN.V..T.L.....F.P........P.E....T...L.D.S.I...S...SS..AW.........W.VA..P.......F..C...G..S..A..AVLVGLLYPCIDDK....LGET..........................................................---PY.Y....KREWSHV.MRCLAVF.....V......GINHAC...A.........KI.......E.........FAN..N....L...QFS........LTLAAMSLGL...WWLFDR.SRS....GFGLA.LTI.AFLATL..ITQLLVY..........................................................----.-..-KG.VY.RYTEP.DF.LYVR...SWLPCVFFSGGVTIGNIGRQLA..........................................................
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D4AY09_ARTBC/172-386              ....................................................................al--QQSGLLFLF.GVTFGVIIMHLHDsp...........qmaDLL.P..L.H.....I.P........V.R....V...E.I.I.N...F...GL..EW.........WhYL..V.......F..W...G..V..A..GVALGNLLPWFDLMwedfMGEN..........................................................PVKGS.S....EAGWNPM.VRSIGAF.....V......GVAFAI...R.........KL.......P.........WQS..S....T...QVC........LTLALVNPFL...WYLIDR.SKS....GFVLS.TAI.GLTGMM..ALLEMNPdiifsp.............................................snaadavD--E.T..VFG.IAgLTLSQ.GQ.LAVG...TWIASVLFCSCVCFGNIGRKLA..........................................................
E7KPH9_YEASL/99-268               ...............................................................ntiaaff------ILFIA.GILFPMISECLFDndqla.....kgdivsF--.-..L.K.....H.G........I.E....I...K.N.K.I...V...AE..PD.........M.VPdwA.......V..F...G..T..E..GVIFGSIVPFIDSF....VRYQh.......................................................qpKTRSSvY....KNTLGSF.IRCSNTL.....L......GLIFGI...R.........KL.......E.........WSS..S....L...QAA........GAWSLLNIVL...WLFFDG.TLT....VFFPG.LVI.GALSA-..-------..........................................................----.-..---.--.-----.--.----...----------------------ftcsqcfsqlsla.............................................
H0ZMV6_TAEGU/2-103                ...................................................................amc-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..-.......-..-...-..-..-..--------------....----..........................................................-----.-....-------.----GSL.....C......GINHAS...A.........KV.......D.........FAN..N....I...QLS........LTLAALSIGL...WWTFDR.SRS....GFGLG.VGI.AFLATL..VSQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFAGGITMGNIGRQLA..........................................................
H0GHH4_9SACH/99-268               ...............................................................ntiaaff------ILFIA.GILFPMISECLFDndqla.....kgdivsF--.-..L.K.....H.G........I.E....I...K.N.K.I...V...AE..PD.........M.VPdwA.......V..F...G..T..E..GVIFGSIVPFIDSF....VRYQh.......................................................qpKTRSSvY....KNTLGSF.IRCSNTL.....L......GLIFGI...R.........KL.......E.........WSS..S....L...QAA........GAWSLLNIVL...WLFFDG.TLT....VFFPG.LVI.GALSA-..-------..........................................................----.-..---.--.-----.--.----...----------------------ftcsqcfsqlsla.............................................
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B3RT72_TRIAD/15-202               ..................................................................lriv-----IALFFI.GVIFALVLNVLQV................QRN.V..A.A.....F.S........R.D....V...L.S.G.La.lFglsMS..TW.........W.ML..P.......S..Y...G..T..G..AVLIGLAFPCADHH....LGES..........................................................---PK.I....KNEWTSI.MRCTALW.....I......GINHAA...A.........TL.......N.........FST..P....A...QLT........FWVSAMSLCL...WWLYDR.TRT....GLFLA.MLS.AVVATG..FNQILVS..........................................................----.-..-NG.VF.SYNEP.DL.LSVK...SWLPSIYFSGGLTIGNIGRQL-v.........................................................
F1NDH8_CHICK/3-103                .................................................................vcsgl-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..-.......-..-...-..-..-..--------------....----..........................................................-----.-....-------.-------.....C......GINHAS...A.........KV.......D.........FAN..N....I...QLS........LTLAALSIGL...WWTFDR.SRS....GFGLG.VGI.AFLATL..VSQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFAGGITMGNIGRQLA..........................................................
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D8LJ79_ECTSI/116-279              .......................................................aykhpielnvaghli-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...L...TT..DW.........W.VP..P.......L..F...A..V..A..GAGIGALYILLDAA....LETP..........................................................--QAQ.R....EPLWRDV.LLSISLF.....S......FQYYLS...G.........LL.......T.........AVGcpN....W...VLV........GSLAVIAERV...FDVFDA.TRA....GLWVS.LAT.ATLGPL..IEIFLVN..........................................................----.-..ATD.LY.MYNGA.DF.FGVD...SWIPIVYFCGGPAVGNLART--iy........................................................
H2V9C8_TAKRU/58-241               ....................................................................ll--RRGLVLFTV.GVFLALVLNLLQI................QRK.V..T.L.....F.P........E.E....V...M.A.T.L...F...SS..TW.........W.IP..P.......C..C...G..T..G..AAVVGLLYPCLDSH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...V.........KL.......N.........IDN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITT.AFLATV..FTQLLVY..........................................................----.-..-NG.VY.QHTSP.DF.LYVR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
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E4UVZ6_ARTGP/175-390              ....................................................................al--QQSGLLFLF.GVTFGVIIMHLHD................SPQ.M..A.AllplhI.P........V.R....V...E.A.I.N...F...GL..EW.........WhYL..V.......F..W...G..V..A..GVALGNLLPWFDLM....WEDFmg.....................................................ekpVQKGS.S....EAGWNPM.VRSIGAF.....V......GVAFAI...R.........KL.......P.........WQS..S....T...QVC........LTLALVNPFL...WYLIDR.SKS....GFVLS.TAI.GLTGMM..ALLEMNPgivfsps............................................dasdalnD---.T..AFG.IAgLTLSQ.GQ.LAVG...TWIASVLFCSCVCFGNIGRKLA..........................................................
G0SFN6_CHATD/203-510              .....................................................................l-TVRAMLLFAL.GVGYGVLVTRLPGdparklqllqvveeglKEE.I..Q.G.....A.T........A.N....G...C.S.S.K...V...AG..GW.........W.YL..M.......I..W...G..I..A..GVALGSFLPWFDRI....WEETiatrvrnagnekptkrqtrqqrqrqrra..salgmqelpnvpssvtnntanseatsagSRAAA.S....QADWPLI.MRGIGAF.....V......GIVFAI...R.........KL.......P.........WTS..T....M...QVS........LTLALANPFL...WYLIDR.SKP....GFFFS.AAV.GLAGSA..VLKLMGLdpgmmpvpimhgrtsplassip..............teqqqhmalqgnvsgandvnggERTA.-..LVW.GE.WGWSQ.ES.VEAS...IWMLSVLFCSCVCFGNIGRRLA..........................................................
D2HTZ4_AILME/944-1103             ..........................................kttlpaaieepvnqdtlaqqdvgfwler-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..-.......-..-...-..-..A..HAVVGLLYPCIDSR....LGEP..........................................................---HK.F....KREWASV.MRCVAVF.....V......GINHAS...A.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITV.AFLATV..ITQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
B6JWJ4_SCHJY/116-301              ..................................................................rvlg----VIIVMFL.GWSFTYLAEKLLL................EAR.L..P.G.....L.R........F.T....V...H.S.Q.Q...Y...KP..HW.........-.-S..L.......L..F...G..F..A..AILVGFSFPYADRL....SHNG..........................................................HRLVA.R....PFEWNLI.VRSIMAL.....S......FVLIGL...K.........RC.......L.........GTD..V....K...QTA........IGFAVNALSV...WFIFDH.TKT....GFVMS.SFF.SSLGTF..LYTAFVE..........................................................--VN.L..SQG.ES.IHISK.--.-SLR...YWLPSIIFFACTVIGNVGRLV-f.........................................................
H9EVZ0_MACMU/84-267               .....................................................................l-VQRSLVLFSV.GVVLALVLNLLQI................QRN.V..T.L.....F.P........E.E....V...I.A.T.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..AAVVGLLYPCIDSH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...A.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITI.AFLATL..ITQFLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
G3RT31_GORGO/84-267               .....................................................................l-VQRSLVLFSV.GVVLALVLNLLQI................QRN.V..T.L.....F.P........E.E....V...I.A.T.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..AAVVGLLYPCIDSH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...A.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITI.AFLATL..ITQFLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
G7YNV0_CLOSI/1-140                ..............................................................mdfkigah-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..-.......-..-...-..-..-..--------------....----..........................................................---DV.Y....NKEWSSV.FRCVALF.....F......GLSHAT...A.........RI.......D.........FAS..Y....A...QLV........IIIGGLSFGL...WWIFDR.TRV....GLCCG.MVA.AIIATL..LGHAF--..........................................................----.-..---.--.-----.--.----...----------------------irrrllscldtlsfllwwsdscsyrtatskagclgtvqekdritvvahtiirrsvysv
G3X2R0_SARHA/28-211               .....................................................................l-VIRGVVLFLI.GVFLALVLNLLQI................QRN.V..T.L.....F.P........P.D....V...I.A.S.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..SAVIGLLYPCIDRH....LGEP..........................................................---HK.F....KREWSSV.MRCVAVF.....V......GINHQT...Q.........KV.......D.........FDN..N....I...QLS........LTLAALSIGL...WWTFDR.SRS....GFGLG.VGI.AFLATL..VTQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFAGGITMGNIGRQLA..........................................................
C5JH58_AJEDS/169-427              .....................................................................l-LLRSALLFIF.GVAYGIIITHL--................HDN.P..R.V.....T.P........I.K....I...E.N.I.D...Li.rRG..SW.........V.YM..V.......F..W...G..G..A..GVALGGLLPWFDVV....WEEFvggdgegeedgagvgekmdggggnvev....snrdltgsgsgsgdgkvnvkvnggqqlKSSQS.I....AADWNQV.VRSIGAF.....V......GIAFAI...R.........KL.......P.........WQS..T....L...QVS........LTLALVNPFL...WYLIDR.SKP....GFMLS.TAV.GLLGMV..TWLGVNPdvvpap..............................................tanvgeANAI.A..GSG.GM.LLASQ.ES.IAVG...TWIASVLFCSCVCFGNIGRRLA..........................................................
C4JUE9_UNCRE/79-309               .....................................................................l-VRKSVFLFLF.GMAYGGIITHLHG................HPK.V.aG.R.....V.P........V.N....M...D.N.I.D...L..dQR..SL.........G.YL..G.......L..W...G..L..A..GVALGSLQPWFDLF....WGDNlivgr...............................................sqaterRSKGS.G....LLEWSPM.VRSIGAF.....V......GIAFAI...R.........KL.......P.........WQS..T....L...QVS........LTLALVNPVL...WYLIDR.SKP....GFVLS.TVV.GLTGML..ALLGINPtivpspataqps.................................sssaavspgtllnSSTL.L..QTA.KV.IGVTQ.ES.LAVG...TWIASVLFCSCVCFGNIGRRLA..........................................................
F7H2Z8_MACMU/1-130                ......................................................................-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..-.......-..-...-..-..-..-AVVGLLYPCIDSH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...A.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITI.AFLATL..ITQFLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
A1CXK5_NEOFI/119-340              ......................................................................QVFRSVLLFGF.GVAYGVITVHL--................HEN.H..W.I.....T.P........V.K....L...E.N.I.R...Y...YD..SW.........Q.YL..G.......L..W...G..L..A..GVALGNVLPWLDSF....AGEWdtgrsrt............................................vkgqennRLRED.R....TPAWVTV.ARSVGAF.....V......GIAFAL...R.........RL.......P.........WES..T....T...QAS........ATLALVNPVL...WYLIDR.TKA....GFLLS.TVV.GLAGTG..VVLGLKPelvptsad.........................................tpattipllNGTV.L..EYG.LP.TGLTQ.EG.VAVR...IWLSSVLFCACVCFGNVGRQLA..........................................................
Q6BJN8_DEBHA/129-321              ................................................fitnmfltnfvhklkpfssfgk-----------.-------------................---.-..-.-.....-.-........-.-....-...-.T.N.T...Y...SI..SW.........IdNF..L.......A..L...S..I..Q..GLVMGLIHPMMDCV....LPTSmtkrl...............................................lssdpnASGSK.D....AHLFNDL.VRALVTF.....L......GISYAV...R.........KI.......E.........WSS..S....L...QVS........MIWSLLNPGL...WLLLDG.TIS....GFLSS.LLI.ATLACL..SVYLQNY..........................................................DLVL.QyaNQF.LQ.LGKDD.DF.IAIW...LYVGSFFFCGLIIFGKLGRGL-f.........................................................
A6ZRS8_YEAS7/111-297              ...................................hylqavlilslsgfayhelsrnlhdnhllhpdfas-----------.-------------................--R.P..L.L.....L.G........V.K....L...C.N.W.L...S...NG..VL.........P.NW..L.......G..Y...G..V..E..GLLFGSVVPILDNI...fQTEV..........................................................VKSSV.H....HDSLTSV.IRSINAM.....L......GVTFGI...R.........KI.......Q.........WNS..S....L...QAA........GAWGLLNIIL...WLFFDG.SIS....MLMSC.ICI.GVGCCI..-------..........................................................----.-..---.--.-----.--.----...----------------------scykdiidgsqflyfmdfyflgslmfgklgryly........................
C4YQ48_CANAW/114-333              plkivvltlasfiynevtsqinfnhtqsnypltikhlfkissyihldeylafvgqskygylidetfalmi-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..-.......-..-...-..-..Q..GLVMASFHPILDYY....LPKSltkrll..............................................ssnpnpSSSTS.Y....STLINDL.IRSSVAF.....L......GVSYAI...R.........NI.......E.........WSS..F....L...QVA........IIYSLVSPGL...WLLLDG.TIS....GLIGS.LVV.SIAACS..VVYYQNY..........................................................---Q.Y..LNG.VG.DASPV.EL.VAIW...LWIGSFVFGGLIVFGKLGRFL-f.........................................................
G5AVC9_HETGA/61-244               .....................................................................l-VQRSLVLFSV.GVVLALVLNLLQI................QRN.V..T.L.....F.P........D.E....V...I.A.T.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..AAVVGLLYPCIDSH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...A.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITI.AFLATL..ITQFLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
G8ZPQ7_TORDC/107-273              ...............fffatsllsiagisyhelsrqlhdnhllhpdfasrplslgveisnlltggrvpdw-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..G.......A..Y...A..L..E..GILFGLSIPLMDHI....FNIK..........................................................----T.P....RNSVGSI.IRSVNAM.....L......GVTFGI...R.........RV.......E.........WSS..S....L...QAA........GAWGLLNIIL...WLLFDS.TSS....MFFGC.SFM.GLLACA..SC-----..........................................................----.-..---.--.-----.--.----...----------------------yrevsdksqflyfmdfyf........................................
B2AXP1_PODAN/179-429              .....................................................................m-ALRASLLFAL.GLGYGVLVTRL--................PRA.Q..N.F.....D.P........Q.Q....P...P.T.T.S...D...EP.lDW.........R.YL..L.......F..W...G..A..S..GVLLGCLLPWFDQF....FIPAakkngpltgkpl..................................psspqqqrqqneREGRQ.Q....EADYVLV.IRSIGLF.....V......GIVFAI...R.........KL.......S.........WTS..T....M...QVS........LTLALINPFI...WYLIDR.SKP....GFLLS.ASV.GLVGTVgmIGLGLKDvfpglmpapsfyqhgd.........................ggglgsgrmrrngsanaGYVA.G..SGG.IK.LVGER.EV.VETG...VWMLSVLFCSCVCFGNIGRRLA..........................................................
I1RNK1_GIBZE/152-371              .....................................................................l-VMRGLLLFVL.GVGYGVLVTSR--................---.F..N.S.....D.S........D.S....Q...A.G.S.T...Y...--..NW.........A.HL..S.......F..W...G..L..A..GVALGALFPWFDRV....WEDSfgekede............................................avaenapAKDDD.S....GTDWAIA.IRAIGAF.....V......GIVFAI...R.........KV.......A.........WAS..T....L...QVS........LTLAMVNPLL...WWLIDR.SKP....GFFLS.TAV.GLAGSM..ILLGINPdmmpapahapf....................................rqlvnattpsqDEVV.P..I--.LG.GFAHQ.ET.LETG...MWMLSVLFCSCVCFGNIGRRL-t.........................................................
G1RMF4_NOMLE/28-211               .....................................................................l-MIRGVVLFFI.GVFLALVLNLLQI................QRN.V..T.L.....F.P........P.D....V...I.A.S.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..SAVIGLLYPCIDRH....LGEP..........................................................---HK.F....KREWSSV.MRCVAVF.....V......GINHAS...A.........KV.......D.........FDN..N....I...QLS........LTLAALSIGL...WWTFDR.SRS....GFGLG.VGI.AFLATV..VTQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFAGGITMGNIGRQLA..........................................................
G1DGF2_CAPHI/28-211               .....................................................................l-MIRGVVLFFI.GVFLALVLNLLQI................QRN.V..T.L.....F.P........P.D....V...I.A.S.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..SAVIGLLYPCIDRH....LGEP..........................................................---HK.F....KREWSSV.MRCVAVF.....V......GINHAS...A.........KV.......D.........FDN..N....I...QLS........LTLAALSIGL...WWTFDR.SRS....GFGLG.IGI.AFLATV..VTQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFAGGITMGNIGRQLA..........................................................
C8Z9S8_YEAS8/99-268               ...............................................................ntiaaff------ILFIA.GILFPMISECLFDndqla.....kgdivsF--.-..L.K.....H.G........I.E....I...K.N.K.I...V...AE..PD.........M.VPdwA.......V..F...G..T..E..GVIFGSIVPFIDSF....VRYQh.......................................................qpKTRSSvY....KNTLGSF.IRCSNTL.....L......GLIFGI...R.........KL.......E.........WSS..S....L...QAA........GAWSLLNIVL...WLFFDG.TLT....VFFPG.LVI.GALSA-..-------..........................................................----.-..---.--.-----.--.----...----------------------ftcsqcfsqlsla.............................................
A3LUC1_PICST/149-312              ..........................................................dfvkladfffav-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..-.......-..-...T..V..Q..GLIMGLIQPIMDKV....LPANfskrll..............................................ssnpfpHAQTT.Y....SNLFNDL.LRASVTF.....L......GISYAI...R.........KI.......E.........WSS..F....L...QVS........IIWSLMNPGL...WLLLDG.TLS....GFLSS.TIV.SLAACG..IVYFENY..........................................................---V.F..VNQ.YY.SLQQE.DS.IAVW...LWVCSFFFCGLIIFGKIGRGL-f.........................................................
E7NIN1_YEASO/100-270              ................................................................tiaaff------ILFIA.GILFPMISECLFDndqla.....kgdivsF--.-..L.K.....H.G........I.E....I...K.N.K.I...V...AE..PD.........M.VPdwA.......V..F...G..T..E..GVIFGSIVPFIESF....VRYQh.......................................................qpKTRSSvY....KNTLGSF.IRCANTL.....L......GLIFGI...R.........KL.......E.........WSS..S....L...QAA........GAWSLLNIVL...WLFFDG.TLT....VFFPG.LVI.GALSA-..-------..........................................................----.-..---.--.-----.--.----...----------------------ftcsqcfsqlslaly...........................................
E7Q4S8_YEASB/99-268               ...............................................................ntiaaff------ILFIA.GILFPMISECLFDndqla.....kgdivsF--.-..L.K.....H.G........I.E....I...K.N.K.I...V...AE..PD.........M.VPdwA.......V..F...G..T..E..GVIFGSIVPFIDSF....VRYQh.......................................................qpKTRSSvY....KNTLGSF.IRCANTL.....L......GLIFGI...R.........KL.......E.........WSS..S....L...QAA........GAWSLLNIVL...WLFFDG.TLT....VFFPG.LVI.GALSA-..-------..........................................................----.-..---.--.-----.--.----...----------------------ftcsqcfsqlsla.............................................
E1ZIZ3_CHLVA/21-194               .........................................................hyahpsllslgpl-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.R...L...ET..CW.........W.VP..L.......L..F...A..A..A..GIILGVSHPLLDAW....QQERg.......................................................gqQPRGG.A....DPSWSFV.LAAITLF.....V......LQYAAS...G.........TL.......E.........EPL..L....R...QALpgglpaldALLLSSGVAL...WWAFDC.SPQ....GLLMA.CLT.AVAGPA..VEVALIN..........................................................----.-..GLH.AY.TYTHP.SF.LGIP...SWIAWVYLAGGPAVGNLGRR--vs........................................................
A6R3L5_AJECN/9-163                .....................................................gvvrangngkvpvqvdr-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..-.......-..-...-..-..-..--------------....-EQL..........................................................KDSGS.I....AADWNQV.VRSIGAF.....V......GIAFAI...R.........KL.......P.........WQS..T....L...QVS........LTLALVNPFL...WYLIDR.SKP....GFMLS.TAV.GLLGMV..TLLGINPdvvqgl.............................................tvnaaesAAAG.N..GSG.IL.SFASQ.ES.IAVG...TWIASVLFCSCVCFGNIGRRLA..........................................................
F1NHV3_CHICK/1-131                ......................................................................-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..-.......-..-...-..-..-..AAVVGLLYPCIDSH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...A.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITI.AFVATL..ITQFLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
G2R9T8_THITE/188-458              .....................................................................l-LLRAGLLFVL.GVGYGVLVTRL--................PQQ.H..G.-.....-.-........R.R....L...A.A.Y.E...S...PY..EW.........R.YL..A.......F..W...G..A..A..GVALGSLLPWFDRF....WEEStasrqrgggapatrkdvav....................pgpragliegveapvtekpSAAAA.P....RADWALV.VRGVGAF.....V......GIVFAI...R.........KL.......P.........WAS..T....M...QVS........LTLALANPFL...WYLIDR.SKP....GFLLS.AAV.GLAGSV..VLMGLNPdvmpaptanahltaaasssslg.............ataandtasgdsggaawgggngnAAAA.A..ATS.LW.GLASQ.ET.IETG...IWMLSVLFCSCVCFGNIGRRLA..........................................................
INSI2_PIG/28-211                  .....................................................................l-MIRGVVLFFI.GVFLALVLNLLQI................QRN.V..T.L.....F.P........P.D....V...I.A.S.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..SAVIGLLYPCIDRH....LGEP..........................................................---HK.F....KREWSSV.MRCVAVF.....V......GINHAS...A.........KV.......D.........FDN..N....I...QLS........LTLAALSIGL...WWTFDR.SRS....GFGLG.VGI.AFLATL..VTQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFAGGITMGNIGRQLA..........................................................
G3NIC8_GASAC/58-241               ....................................................................li--RRGLVLFTV.GAFLALVLNLLQI................QRH.V..T.L.....F.P........E.E....V...M.A.T.L...F...SS..AW.........W.IP..P.......C..C...G..T..G..AAVVGLLYPCLDSH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...V.........KL.......D.........FDN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GFGLG.ITT.AVLATV..FTQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
G1M1N7_AILME/28-211               .....................................................................l-MIRGVVLFFI.GVFLALVLNLLQI................QRN.V..T.L.....F.P........P.D....V...I.A.S.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..SAVIGLLYPCIDRH....LGEP..........................................................---HK.F....KREWSSV.MRCVAVF.....V......GINHAS...A.........KV.......D.........FDN..N....I...QLS........LTLAALSIGL...WWTFDR.SRS....GFGLG.VGI.AFLATV..VTQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFAGGITMGNIGRQLA..........................................................
C0NAF6_AJECG/172-435              .....................................................................l-LLRSALLFVF.GVVYGTIITHL--................HDN.P..R.V.....T.P........I.K....I...E.N.I.D...Vi.kRG..SW.........V.YM..V.......F..W...G..V..A..GVALGGLLPWFDVV....WEEFvegesegegvvvggeetegssgnvevsnrdlngsgdgsgvvrangngkvpvqvdreqlKDSGS.I....AADWNQV.VRSIGAF.....V......GIAFAI...R.........KL.......P.........WQS..T....L...QVS........LTLALVNPFL...WYLIDR.SKP....GFMLS.TAV.GLLGMV..TLLGINPdvvpgp.............................................tvnaaesAVAG.N..GSG.IL.SFASQ.ES.IAVG...TWIASVLFCSCVCFGNIGRRLA..........................................................
A4D2M9_HUMAN/84-267               .....................................................................l-LQRSLVLFSV.GVVLALVLNLLQI................QRN.V..T.L.....F.P........E.E....V...I.A.T.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..AAVVGLLYPCIDSH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...A.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITI.AFLATL..ITQFLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
G2YX13_BOTF4/109-338              .....................................................................r-VFRSVLLFGL.GLLYGLLVKHL--................HDD.R..H.L.....A.P........L.Q....V...E.T.IiK...P...SH..DW.........K.YL..V.......F..W...G..I..A..GVGLGSVLPLVDKF....WEERvqlpfesstc......................................tpseeaidvsNSQGV.L....GGDWILA.VRSVGAF.....V......GIAYAI...R.........KL.......P.........WAS..D....M...QAS........LALALVNPVL...WYLIDR.SKP....GLAFS.AAV.GATGSV..LLLASNSdlmpspaas........................................mknntvshqPADY.S..EAE.SE.KLVTR.GN.LEAG...IWIASVLFCSCVCFGNIGRRLA..........................................................
C4Y5U1_CLAL4/94-302               ...ilfrvatvstaalvynevtkhihasnlndigtqinaylvtfmenwkpirylanvdhpadaffslase-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..-.......-..-...-..-..-..GLILSSILPLLDNV....MPGSfskr.................................................llsssPDPYY.R....SNLMNDI.VRSSIAF.....L......GVSYAI...R.........HI.......E.........WKS..S....L...QMA........MTWSLINPCL...WLLLDG.TIS....GFIAS.TGT.AFGGSA..IVYY---..........................................................----.-..QNG.VK.FSTDK.DTdLIIL...LFIASFFFCGVIIFGKLGRLLF..........................................................
B5VK66_YEAS6/100-269              ................................................................tiaaff------ILFIA.GILFPMISECLFDndqla.....kgdivsF--.-..L.K.....H.G........I.E....I...K.N.K.I...V...AE..PD.........M.VPdwA.......V..F...G..T..E..GVIFGSIVPFIDSF....VRYQh.......................................................qpKTRSSvY....KNTLGSF.IRCSNTL.....L......GLIFGI...R.........KL.......E.........WSS..S....L...QAA........GAWSLLNIVL...WLFFDG.TLT....VFFPG.LVI.GALSA-..-------..........................................................----.-..---.--.-----.--.----...----------------------ftcsqcfsqlslal............................................
A1L3F8_XENLA/55-238               ....................................................................li--RRSLVLFSV.GAFLALVLNLLQV................QRN.V..T.L.....F.P........E.E....V...I.A.T.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..AAVVGLLYPCIDSR....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...A.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITI.AFLATL..ITQFLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
INSI2_XENTR/21-204                .....................................................................l-LLRGLLLFLI.GVFLALVLNLLQV................QRN.V..T.L.....F.P........P.D....V...L.S.S.L...F...SS..AW.........W.VP..L.......C..C...G..T..A..AAAIGLLYPCIDRH....LGEP..........................................................---HK.F....KREWSSV.MRCVAVF.....V......GINHAS...A.........KV.......D.........FAN..N....T...QLS........LTLAALSIGL...WWTFDR.SRS....GLGLG.IGI.SFFATV..VSQLLVY..........................................................----.-..-NG.VY.EYTAP.DF.LYVR...SWLPCIFFAGGITMGNIGRQL-e.........................................................
Q7SBU0_NEUCR/218-500              ....................................................................sl--LRTTLLFAL.GAGYGVLVTRL--................---.-..-.-.....-.-........P.N....G...D.S.V.T...G...GY..GW.........R.YL..T.......F..W...G..A..A..GVVLGRLLPWFDQV....WEEAfgkrtrmtkkekerrraaaaaeaaaallqqappsssrtfprktpvtttlpvetdsnsgGVTSP.P....EADWPLV.VRSIGAF.....V......GIVFAI...R.........RL.......P.........WAS..T....M...QVS........ITLALANPFL...WYLIDR.SKP....GFLLS.AAV.GVTGSA..ILMGLGNpdmmpapvagagyhdhhfltt................sgqpamdvlngttsglprsaaAARM.S..GMG.GA.SSENA.AV.IETG...IWMLSVLFCSCVCFGNIGRRLA..........................................................
H3D5G0_TETNG/58-241               ....................................................................ll--RRGLVLFTV.GASLALVLNLLQI................QRK.V..T.L.....F.P........E.E....V...I.T.T.L...F...SS..TW.........W.IP..P.......C..C...G..T..G..AAVVGLLYPCLDSH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...V.........KL.......N.........FDN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GFGLG.ITT.AFLATV..FVQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
C7YYL3_NECH7/151-376              .....................................................................l-ALRGLVLFVL.GVGYGILVTTR--................PDS.L..K.S.....L.R........G.N....M...I.R.P.A...Y...--..NW.........A.HL..A.......F..W...G..F..A..GVALGALLPWLDRV....WEESfgddgeea..........................................vaendgasTKDDG.P....STDWALV.VRAIGAF.....V......GIVFAIvwqR.........KV.......A.........WAS..T....L...QVS........LTLALVNPLL...WWLIDR.SKP....GLFLS.AVV.GLTGSV..LLLGVNPeimpapthv........................................algnfslgqDGDH.D..LPV.LG.GLARQ.ET.LETG...VWMLSVLFCSCVCFGNIGRRLA..........................................................
H7C5L3_HUMAN/1-176                .....................................................................x---------SV.GVVLALVLNLLQI................QRN.V..T.L.....F.P........E.E....V...I.A.T.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..AAVVGLLYPCIDSH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...A.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITI.AFLATL..ITQFLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
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B9RNA1_RICCO/52-247               ..................................................................sval------SLFGS.GFFLGPLIDGLHS................RVN.L..V.V.....YqT........G.S....V...D.I.G.P...L...HT..NI.........W.VP..P.......L..L...G..L..F..YSTVGLTQLFLDER....APSK..........................................................-IQEA.N....AEKVVAT.LVALLLF.....M......ELSAEM...Y.........EA.......G.........IPD..N....I...EAY........ILFAAA-EVI...WLFLDR.TRV....GFTLA.SII.GLGCP-..-------..........................................................----.-..---.--.-----.--.----...----------------------laeipimrffhlwsyphanieilgqglvtwtitcyfvytpflislarwlqsviaaad.
C8ZG73_YEAS8/111-297              ...................................hylqavlilslsgfayhelsrnlhdnhllhpdfas-----------.-------------................--R.P..L.L.....L.G........V.K....L...C.N.W.L...S...NG..VL.........P.NW..L.......G..Y...G..V..E..GLLFGSVVPILDNI...fQTEV..........................................................VKSSV.H....HDSLTSV.IRSINAM.....L......GVTFGI...R.........KI.......Q.........WNS..S....L...QAA........GAWGLLNIIL...WLFFDG.SIS....MLMSC.ICI.GVGCCI..-------..........................................................----.-..---.--.-----.--.----...----------------------scykdiidgsqflyfmdfyflgslmfgklgryly........................
INSI1_XENTR/58-241                ....................................................................li--RRSLVLFAV.GVFLALVLNLLQI................QRN.V..T.L.....F.P........E.E....V...I.A.T.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..AAVVGLLYPCIDSH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...A.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITI.AFLATL..ITQFLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
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F7H2V2_MACMU/1-130                ......................................................................-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..--.........-.--..-.......-..-...-..-..-..-AVVGLLYPCIDSH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...A.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITI.AFLATL..ITQFLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
F6YYC7_CALJA/84-143               .....................................................................l-VQRSLVLFSV.GVVLALVLNLLQI................QRN.V..T.L.....F.P........E.E....V...I.A.T.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..A-------------....----..........................................................-----.-....-------.-------.....-......------...-.........--.......-.........---..-....-...---........----------...------.---....-----.---.------..-------..........................................................----.-..---.--.-----.--.----...----------------------gthpqt....................................................
G3X2R1_SARHA/28-211               .....................................................................l-VIRGVVLFLI.GVFLALVLNLLQI................QRN.V..T.L.....F.P........P.D....V...I.A.S.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..SAVIGLLYPCIDRH....LGEP..........................................................---HK.F....KREWSSV.MRCVAVF.....V......GINHQT...Q.........KV.......D.........FDN..N....I...QLS........LTLAALSIGL...WWTFDR.SRS....GFGLG.VGI.AFLATL..VTQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFAGGITMGNIGRQLA..........................................................
G3AY76_CANTC/102-323              ...............................ilkaavlsvcaytyneitrhirnnhiklgaqtfqplflt-----------.--------ELFLT................KSF.H..A.V.....E.P........L.K....V...L.S.K.N...F...TP..SQ.........N.YA..T.......V..L...V..F..Q..GMIMGLVHPFLDFV....IPPKhnrrlf..............................................ssnpdpKKRYE.P....ATLFNDI.LRSLITF.....L......GISYAI...R.........NL.......E.........WSS..S....L...QVS........VVWSLLSPCL...WLLLDG.TVA....GLLAG.LVV.TVWGCL..FVYSMNS..........................................................--DL.I..N-I.YT.SFESS.DF.IAIW...LWTSSFFFCGMIIFGKIGRALF..........................................................
F2T2W4_AJEDA/169-427              .....................................................................l-LLRSALLFIF.GVAYGIIITHL--................HDN.P..R.V.....T.P........I.K....I...E.N.I.D...Li.rRG..SW.........V.YM..V.......F..W...G..G..A..GVALGGLLPWFDVV....WEEFvggdgegeedgagvgekmdggggnvev....snrdltgsgsgsgdgkvnvkvnggqqlKSSQS.I....AADWNQV.VRSIGAF.....V......GIAFAI...R.........KL.......P.........WQS..T....L...QVS........LTLALVNPFL...WYLIDR.SKP....GFMLS.TAV.GLLGMV..TWLGVNPdvvpap..............................................tanvgeANAI.A..GSG.GM.LLASQ.ES.IAVG...TWIASVLFCSCVCFGNIGRRLA..........................................................
INSI2_MOUSE/28-211                .....................................................................v-VIRGVVLFFI.GVFLALVLNLLQI................QRN.V..T.L.....F.P........P.D....V...I.T.S.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..SAVIGLLYPCIDRH....LGEP..........................................................---HK.F....KREWSSV.MRCVAVF.....V......GINHAS...A.........KV.......D.........FDN..N....F...QFS........LTLAALSVGL...WWTFDR.SRS....GFGLG.VGI.AFLATV..VTQLLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYVR...SWLPCIFFAGGITMGNIGRQLA..........................................................
B3S4T4_TRIAD/3-189                .....................................................................f-LLRTLIVFVV.GVLLSLALLILQI................ERN.V..A.L.....F.P........P.G....V...L.S.D.L...S...SI..PW.........W.VP..I.......S..C...G..A..G..AATIGLSLPKMDEW....FQRK..........................................................YDYHH.D....QVEWVGV.LRCVGIF.....V......GITYAS...T.........-L.......A.........YNS..V...iA...KFS........VSLSLMAIGQ...WWLFDR.SVS....GFVLG.VAV.SFTATA..VTQIIVH..........................................................----.-..-YG.IF.SFSKP.DF.LSIR...SWLPGVFFSATIAIGSLGRQLA..........................................................
G0W6S5_NAUDC/137-308              ..................liysgsvlficgllfgelskflfdnhdlqkgglsivfknlvqlldkiitvsk-----------.-------------................---.-..-.-.....-.-........-.-....-...-.-.-.-...-...--..VT.........E.YI..-.......G..F...G..I..Q..GIILGVILKISDNI....FRPSk........................................................eKTGIN.R....KNSFRSI.IRLVNAM.....L......GISLGV...R.........RL.......P.........WTS..S....N...QGS........ILWLLLNVIV...WLFFDG.SLS....FLMSG.IVQ.TLFIAF..FYYN---..........................................................----.-..---.--.-----.--.----...----------------------rfdhmsqllylinf............................................
E7LZH0_YEASV/111-244              ....................................hylqavlilslsgfayhelsrnlhdnhllhpdfa-----------.-------------................-SR.P..L.L.....L.G........V.K....L...C.N.W.L...S...NG..VL.........P.NW..L.......G..Y...G..V..E..GLLFGSVVPILDNI...fQTEV..........................................................VKSSV.H....HDSLTSV.IRSINAM.....L......GVTFGI...R.........KI.......Q.........WNS..S....L...QAA........GAWGLLNIIL...WLFF--.---....-----.---.------..-------..........................................................----.-..---.--.-----.--.----...----------------------..........................................................
H2V9C9_TAKRU/23-206               ....................................................................ll--RRGLVLFTV.GVFLALVLNLLQI................QRK.V..T.L.....F.P........E.E....V...M.A.T.L...F...SS..TW.........W.IP..P.......C..C...G..T..G..AAVVGLLYPCLDSH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...V.........KL.......N.........IDN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITT.AFLATV..FTQLLVY..........................................................----.-..-NG.VY.QHTSP.DF.LYVR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
E0CXF1_MOUSE/28-146               .....................................................................v-VIRGVVLFFI.GVFLALVLNLLQI................QRN.V..T.L.....F.P........P.D....V...I.T.S.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..SAVIGLLYPCIDRH....LGEP..........................................................---HK.F....KREWSSV.MRCVAVF.....V......GINHAS...A.........KV.......D.........FDN..N....F...QFS........LTLAALSVGL...WW----.---....-----.---.------..-------..........................................................----.-..---.--.-----.--.----...----------------------..........................................................
F6US22_MONDO/84-267               .....................................................................l-VQRSVVLFAV.GVFLALVLNLLQI................QRN.V..T.L.....F.P........E.E....V...I.A.T.I...F...SS..AW.........W.VP..P.......C..C...G..T..A..AAVVGLLYPCIDSH....LGEP..........................................................---HK.F....KREWASV.MRCIAVF.....V......GINHAS...A.........KL.......D.........FAN..N....V...QLS........LTLAALSLGL...WWTFDR.SRS....GLGLG.ITI.AFLATL..ITQFLVY..........................................................----.-..-NG.VY.QYTSP.DF.LYIR...SWLPCIFFSGGVTVGNIGRQLA..........................................................
C7GXV6_YEAS2/111-297              ...................................hylqavlilslsgfayhelsrnlhdnhllhpdfas-----------.-------------................--R.P..L.L.....L.G........V.K....L...C.N.W.L...S...NG..VL.........P.NW..L.......G..Y...G..V..E..GLLFGSVVPILDNI...fQTEV..........................................................VKSSV.H....HDSLTSV.IRSINAM.....L......GVTFGI...R.........KI.......Q.........WNS..S....L...QAA........GAWGLLNIIL...WLFFDG.SIS....MLMSC.ICI.GVGCCI..-------..........................................................----.-..---.--.-----.--.----...----------------------scykdiidgsqflyfmdfyflgslmfgklgryly........................
#=GC seq_cons                     .....................................................................h...pshlLF.h.GhhhuhllphL..................ppp.h..h.l.....h.s..........c....l.....s...h...h...ss..sW.........h.h...s.......h..h...G..s..u..usllGhLhPhlDph....hs-s.............................................................pp.h....pppWsuV.hRslusF.....V......GIsaA....t.........Kl.......s.........ass..s....l...QlS........LTLAhLslsL...WahFDR.S+o....GhhLu.lsl.uhlusl..hh.hls....................................................................tu.lh.phso..-h.lhlt...sWlsslhFsuslshGNIGRpLA..........................................................
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