GenomeNet

Database: Pfam
Entry: IncA
LinkDB: IncA
Original site: IncA 
#=GF ID   IncA
#=GF AC   PF04156.13
#=GF DE   IncA protein
#=GF AU   Bateman A
#=GF SE   Pfam-B_2718 (release 7.3)
#=GF GA   50.00 50.00;
#=GF TC   50.00 50.30;
#=GF NC   49.30 48.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12065525
#=GF RT   Inhibition of Fusion of Chlamydia trachomatis Inclusions at 32
#=GF RT   degrees C Correlates with Restricted Export of IncA. 
#=GF RA   Fields KA, Fischer E, Hackstadt T; 
#=GF RL   Infect Immun 2002;70:3816-3823.
#=GF DR   INTERPRO; IPR007285;
#=GF DR   TC; 9.B.159;
#=GF CC   Chlamydia trachomatis is an obligate intracellular bacterium
#=GF CC   that develops within a parasitophorous vacuole termed an
#=GF CC   inclusion. The inclusion is non-fusogenic with lysosomes but
#=GF CC   intercepts lipids from a host cell exocytic pathway. Initiation
#=GF CC   of chlamydial development is concurrent with modification of the
#=GF CC   inclusion membrane by a set of C.  trachomatis-encoded proteins
#=GF CC   collectively designated Incs. One of these Incs, IncA, is
#=GF CC   functionally associated with the homotypic fusion of inclusions
#=GF CC   [1]. This family probably includes members of the wider Inc
#=GF CC   family rather than just IncA. Members are usually either 2 or
#=GF CC   4TM proteins.
#=GF SQ   19
#=GS O84226_CHLTR/33-216      AC O84226.1
#=GS S7INI1_CHLPS/60-260      AC S7INI1.1
#=GS S4MC66_CHLPS/33-203      AC S4MC66.1
#=GS O84231_CHLTR/32-194      AC O84231.1
#=GS S7KA07_CHLPS/28-144      AC S7KA07.1
#=GS INCA1_CHLTR/24-223       AC P0CI27.1
#=GS S7IM46_CHLPS/33-203      AC S7IM46.1
#=GS A0A0F8AFM8_LARCR/62-234  AC A0A0F8AFM8.1
#=GS S7IJD8_CHLPS/25-211      AC S7IJD8.1
#=GS S4MBK9_CHLPS/25-195      AC S4MBK9.1
#=GS S7IKJ6_CHLPS/23-194      AC S7IKJ6.1
#=GS S4M3L1_CHLPS/23-194      AC S4M3L1.1
#=GS S7ILX4_CHLPS/29-240      AC S7ILX4.1
#=GS S7IRL6_CHLPS/42-242      AC S7IRL6.1
#=GS S7K3V0_CHLPS/33-203      AC S7K3V0.1
#=GS S7IIL6_CHLPS/25-227      AC S7IIL6.1
#=GS S7JBE4_CHLPS/25-209      AC S7JBE4.1
#=GS S7K0G6_CHLPS/18-203      AC S7K0G6.1
#=GS Y288_CHLTR/32-214        AC O84290.1
O84226_CHLTR/33-216                 ..g-LCYKISAVAALVLGLL.AAAGGAVV.LALFCT-FAPPLFFYAGVALVALGAVILGVGVSNTCSCCLRSR--------...................-----KIEAHKQLILQQKEEISQ..LEQQLAKALKELNTKYPASLL--....-ERRDLRENLKAWQSCCLNLEKEVRDLLtkl......ggyqERLKVLPAKEKQIEELKAM....LEHYSRICHERGELINLLK--tankkl........................
S7INI1_CHLPS/60-260                 ..s-VLQRIFHLIKIISAVS.LFAVGIAA.LICLQ--FGVAVSTLSLVLMIAIMLVSFVIVIMVIQDSTPSQVARRMKQQLhqfsqent..rlhqevdtlVSANRDLANQISELTQLHEKLSD..FGNKLETCTGEFDELISEFKVNL....EAFKSVGTRVETIISPFERLAESLTGVF.............----SKDAVKNMVDAVSAL....RVEMETLKQHVEESRAVLQQL..............................
S4MC66_CHLPS/33-203                 ..q-KNRLIISISILILALL.A-VIMIGG.FIAALFSPKGIYIGIAALISLLIGIILFPLII-TCSSKPPVAHIRPRDL--...................-----DLSKLDVRYNRLLHETIK..EDEKKYAKEQEAKLQRRQRRSLR....TLPRRKQVEASSSDEVQKPRRRTSSVLN.............-------------------....---------------------lirprnssspssnsssldsddsssdhntqq
O84231_CHLTR/32-194                 .nt--CSKILDIALAIVGAL.VVVAGVLA.LVLCASN---VIFTAIGIAALIIGSACVGAGISRLMCRSSYASLEAKNVLA...................----------EQRLRNLSEEKDA..LVSVSFINKMFLRGLTDDLQALE...aKAIEVEIDCLDRLEKNEQALLSDVRLVL.............-------------------....SSYTRWLDSAEKEKAAL----kasidanq......................
S7KA07_CHLPS/28-144                 ...SKYQRVANAIALLAGMA.LIGTLIGA.LVCFALPASLTLVALVSSSLLA-SVILLSISMYNLVSQSRRASSYAQIGKE..................nTRLRAEIIELKEKLAHPEARLEE..EQKIQSSNTS-------------....----------------------------.............-------------------....---------------------ssqsgsks......................
INCA1_CHLTR/24-223                  pqp----SLMDKIKKIAAIAsLILIGTIGfLALLGHLVGFLIAPQITIVLLALFIISLAGNALYLQKTANLHLYQDLQREV...................----GSLKEINFMLSVLQKEFLH..LSKEFATTSKDLSAVSQDFYSCL....QGFRDNYKGFESLLDEYKNSTEEMRKLFsqeiiadlkgsvaSLREEIRFLTPLAEEVRRL....AHNQQSLTVVIEELKTIRDS-l.............................
S7IM46_CHLPS/33-203                 ..q-KNRLIISISILILALL.A-VIMIGG.FIAALFSPKGIYIGIAALISLLIGIILFPLII-TCSSKPPVAHIRPRDL--...................-----DLSKLDVRYNRLLHETIK..EDEKKYAKEQEAKLQRRQRRSLR....TLPRRKQVEASSSDEVQKPRRRTSSVLN.............-------------------....---------------------lirprnssspssnsssldsddsssdhntqq
A0A0F8AFM8_LARCR/62-234             sgw-----------------.--------.-----------LPCCLGILCIILVSVLIALGVILTLKHKTELKQLKKKQTSlladknnltelnhklssanQNLTREHNNLTRAYAVLESNLTD..LKSQNQEVETQNQQLKGQITNLT....SQTQEVGTQNQQLREEKKNLTARIQELQkl........wnqNISQAQ-------------....---------------------msvnlycpitreiieemdyvntsvtt....
S7IJD8_CHLPS/25-211                 phi---VLITSILAVIAGLA.VIASVIAL.LVIYHAQSSAIFNGILISIVLGVILILCIGGRHSCIILQLARLHSP-----...................-----EVSGSESVIQKLQTYSQD..LQNRLSEEDCLLQNQRNHEIEEAlqmqTLLKSKQNELNSLTHRYAAMAQEHADLE............kMVSRLRKELVELKHTLEGN....QVASHIVIERLQASNELLKK-esi...........................
S4MBK9_CHLPS/25-195                 phi---VLITSILAVIAGLA.VIASVIAL.LVIYHAQSSAIFNGILISIVLGVILILCIGGRHSCIILQLARLHSP-----...................-----EVSGSESVIQKLQTYSQD..LQNRLSEEDCLLQNQRNHEIEEAlqmqTLLKSKQNELNSLTHRYAAMAQEHADLE............kMVSRLRKELVELKHTLEGN....Q--------------------vashiv........................
S7IKJ6_CHLPS/23-194                 .ce--KQLLVYTTLIAINVV.FILSNVIA.VAAFAS-LLPSFVVVLSVTSVILGLALLALGVKHIFAYPRKIKTVDF----...................----GKHNEYRSTIQKLLLEIQG..LQNKVLDYKRGALEMKKEYDSLVqtciEDKAAYIDSEETWRFENDELESCIDKLN.............-------------ERINDL....QQINEDCENRLQEEQRMH---fes...........................
S4M3L1_CHLPS/23-194                 .ce--KQLLVYTTLIAINVV.FILSNVIA.VAAFAS-LLPSFVVVLSVTSVILGLALLALGVKHIFAYPRKIKTVDF----...................----GKHNEYRSTIQKLLLEIQG..LQNKVLDYKRGALEMKKEYDSLVqtciEDKAAYIDSEETWRFENDELESCIDKLN.............-------------ERINDL....QQINEDCENRLQEEQRMH---fes...........................
S7ILX4_CHLPS/29-240                 ..h-VSRKTVSLTLIAVGII.LVISGILL.LTLTITSLPSAFSIALGATVLALGTSLASFGVALRILKKPRVNNEGEVVLAtelmnmkq..vveqkteevNRLQGEVSASQTQLAEISEALTT..TRELGNNLQSRLDESSELLTQSR....ENLGAVEARLQTTEETLSQKEEQLARSQ............gELQAEQAKVAQLEAQVRDLesqlQETSANLDRAIASQQDLMERL..............................
S7IRL6_CHLPS/42-242                 ..s-VLQRIFHLIKIISAVS.LFAVGIAA.LICLQ--FGVAVSTLSLVLMIAIMLVSFVIVIMVIQDSTPSQVARRMKQQLhqfsqent..rlhqevdtlVSANRDLANQISELTQLHEKLSD..FGNKLETCTGEFDELISEFKVNL....EAFKSVGTRVETIISPFERLAESLTGVF.............----SKDAVKNMVDAVSAL....RVEMETLKQHVEESRAVLQQL..............................
S7K3V0_CHLPS/33-203                 ..q-KNRLIISISILILALL.A-VIMIGG.FIAALFSPKGIYIGIAALISLLIGIILFPLII-TCSSKPPVAHIRPRDL--...................-----DLSKLDVRYNRLLHETIK..EDEKKYAKEQEAKLQRRQRRSLR....TLPRRKQVKASSSDEVQKPRRRTSSVLN.............-------------------....---------------------lirprnssspssnsssldsddsssdhntqq
S7IIL6_CHLPS/25-227                 ...SRVHVLTTIISLIASLL.IITGAIAA.VVLFGTQLGVLYSTVIIGISVAIGVLLFSASLKCFSCHAVISQSQRFSEDT...................PRSHIHDSRPSEAPALTEESIDA..IERELRTLMSEHEQERLNHQYFV....SQRDLAKISMDSAREEFDNAYTDFQRFQellivgdcgnlvsDCQESLSRLREKSLNYARS....LQCYEDLLQQLHSHQDLID--fr............................
S7JBE4_CHLPS/25-209                 ..p-HVVLITSIIAVILGLA.VITAGIAL.LVISHALSSAIFNGILISIVLGVTLILCIGGGHSCIILQLARLHRS-----...................-----EVSGSENVIQELQTSSQD..LQNCLSEEDHPLQSQQNQEIEDAlqmqALLKSKQDELDSLTHRYAAMAQEHSYLE............nTVSRLRKELVELRRVLEEN....QATSQLVIEKLQVSNELLNK-e.............................
S7K0G6_CHLPS/18-203                 .tn--SHIIINTIAIVSGIL.IIASSIAA.CVFLGADLGLLSAILLGMAIIA-GLLLIALGVYFCCQSSSPQQVTPSVIEQ...................----ERVLELTQQLATANNELAS..LRLSNQENQIGIETSLSSISEEQ...rDLLQERCERIVQLDSIIHQLRKEHALLL.............ESKEEECYREVVRQTNLRL....QLDHRHQQEMESKERSIRER-t.............................
Y288_CHLTR/32-214                   ..a-KAMRITGIALAALSLLaVVACVIAV.------SAGGAAIPLAVISGIAVMSGLLSAATIICSAKKALAQRKQKQLEE...................---SLPLDNATEHVSYLTSDTSYfnQWESLGALNKQLSQIDLTIQAPEk..kLLKEVLGSRYDSINHSIEEISDRFTKML.............SLLRLREHFYRGEERYAPY....------LSPPLLNKNRLL---tqitsn........................
#=GC seq_cons                       ..t...phIhslhhllhulh.llsssIuu.llhhth..sshhssllslhslulsllLhshulhph.spsshtptpsh............................clsp.ppplspLppchps..hppphtspppthpp.ppphpp.h....phhcshtsphpohpcphcthtpphstL...........................tthtt.........t.h....tt.tthh...h.............................
//
DBGET integrated database retrieval system