GenomeNet

Database: Pfam
Entry: IncA
LinkDB: IncA
Original site: IncA 
#=GF ID   IncA
#=GF AC   PF04156.12
#=GF DE   IncA protein
#=GF AU   Bateman A
#=GF SE   Pfam-B_2718 (release 7.3)
#=GF GA   50.00 50.00;
#=GF TC   50.00 52.20;
#=GF NC   48.60 43.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12065525
#=GF RT   Inhibition of Fusion of Chlamydia trachomatis Inclusions at 32
#=GF RT   degrees C Correlates with Restricted Export of IncA. 
#=GF RA   Fields KA, Fischer E, Hackstadt T; 
#=GF RL   Infect Immun 2002;70:3816-3823.
#=GF DR   INTERPRO; IPR007285;
#=GF DR   TC; 9.B.159;
#=GF CC   Chlamydia trachomatis is an obligate intracellular bacterium
#=GF CC   that develops within a parasitophorous vacuole termed an
#=GF CC   inclusion. The inclusion is non-fusogenic with lysosomes but
#=GF CC   intercepts lipids from a host cell exocytic pathway. Initiation
#=GF CC   of chlamydial development is concurrent with modification of the
#=GF CC   inclusion membrane by a set of C.  trachomatis-encoded proteins
#=GF CC   collectively designated Incs. One of these Incs, IncA, is
#=GF CC   functionally associated with the homotypic fusion of inclusions
#=GF CC   [1]. This family probably includes members of the wider Inc
#=GF CC   family rather than just IncA. Members are usually either 2 or
#=GF CC   4TM proteins.
#=GF SQ   31
#=GS Q9JRW8_CHLPN/24-204      AC Q9JRW8.1
#=GS O84226_CHLTR/33-216      AC O84226.1
#=GS Y065_CHLPN/27-189        AC Q9Z9B6.2
#=GS Q9K1Y1_CHLPN/1-168       AC Q9K1Y1.1
#=GS Q9K1Z0_CHLPN/245-436     AC Q9K1Z0.1
#=GS A0A0E2J2V1_CHLPS/9-206   AC A0A0E2J2V1.1
#=GS A0A0E2J222_CHLPS/23-193  AC A0A0E2J222.1
#=GS A0A0E2J147_CHLPS/33-203  AC A0A0E2J147.1
#=GS Q9JS25_CHLPN/1-184       AC Q9JS25.1
#=GS Q9Z8V9_CHLPN/28-216      AC Q9Z8V9.1
#=GS A0A0E2J0K3_CHLPS/47-247  AC A0A0E2J0K3.1
#=GS O84231_CHLTR/32-194      AC O84231.1
#=GS INCA1_CHLTR/24-223       AC P0CI27.1
#=GS Q9Z7W9_CHLPN/47-283      AC Q9Z7W9.1
#=GS Q9Z6K4_CHLPN/1-168       AC Q9Z6K4.1
#=GS Q9Z8Z8_CHLPN/32-228      AC Q9Z8Z8.1
#=GS Q9K1Z0_CHLPN/25-134      AC Q9K1Z0.1
#=GS A0A0E2IZH6_CHLPS/1-206   AC A0A0E2IZH6.1
#=GS Q9K1Z0_CHLPN/135-243     AC Q9K1Z0.1
#=GS Q9Z382_CHLPN/25-184      AC Q9Z382.1
#=GS A0A0E2J214_CHLPS/25-227  AC A0A0E2J214.1
#=GS A0A0E2J210_CHLPS/28-235  AC A0A0E2J210.1
#=GS A0A0E2JEY4_CHLPS/22-207  AC A0A0E2JEY4.1
#=GS Q9K1Z3_CHLPN/1-173       AC Q9K1Z3.1
#=GS Q9JRX6_CHLPN/1-171       AC Q9JRX6.1
#=GS Q9K202_CHLPN/1-155       AC Q9K202.1
#=GS Q9K1Z4_CHLPN/1-167       AC Q9K1Z4.1
#=GS A0A0E2J1X5_CHLPS/23-139  AC A0A0E2J1X5.1
#=GS A0A0E2J2L4_CHLPS/25-209  AC A0A0E2J2L4.1
#=GS Q9Z8W9_CHLPN/27-213      AC Q9Z8W9.1
#=GS Y288_CHLTR/32-214        AC O84290.1
Q9JRW8_CHLPN/24-204                 .ls--KFRVLAITFLVLGVL.LLISGALF.LTLGISG----VSLGVGLGLSALGSVLVISGFLLLLERREVSGVGLEGIPTgipvg......................psaepsSEEIQKKQKAKQILDQLPQELDQ..LDTDIQHVLSCLGKLKDLKCKDR....GLLKDAKEKLQVFDFVWKDMMMEFVELQ......................-------QVMDQESRYLEG....---------LIHEVQSIA---hkl...........................
O84226_CHLTR/33-216                 ..g-LCYKISAVAALVLGLL.AAAGGAVV.LALFCT-FAPPLFFYAGVALVALGAVILGVGVSNTCSCCLRSR--------.................................-----KIEAHKQLILQQKEEISQ..LEQQLAKALKELNTKYPASLL--....-ERRDLRENLKAWQSCCLNLEKEVRDLLtkl...............ggyqERLKVLPAKEKQIEELKAM....LEHYSRICHERGELINLLK--tankkl........................
Y065_CHLPN/27-189                   ...PKVARVLQITAVVLGII.ALLSGIVL.IIGTP--LGAPISMILGGCLLASGGALFVGGTIATILQARNSYKKAVN---.................................-----------------QKKLSEplMERPELKALDYSLDLKEVWDLHH....----SVVKHLKKLDLNLSETQREVLNQI......................---KIDDEGPSLGECAAMI....SENYDACLKMLAYREELLKE-q.............................
Q9K1Y1_CHLPN/1-168                  ...---------------ML.LLISGALF.LTLGIPGLSAAISFGLGIGLSALGGVLMISGLLCLLVKREIPTVRPEEIPEgv............................slaPSEEPALQAAQKTLAQLPKELDQ..LDTDIQEVFACLRKLKDSKYESR....SFLNDAKKELRVFDFVVEDTLSEIFELR......................------QIVAQEGWDL---....---------------------nflinggrslmmtaeses............
Q9K1Z0_CHLPN/245-436                ..m-RKLRILAIVLIVFSII.LIASGVVL.LTVAIPGLSSIISSPAEMGACALGCVMLALGIDVLLKKREVPIVVPAPIPEevvi.........................ddidEESIRLQQEAEAALARLPEEMSA..FEGYIKVVESHLENMKSLPYDGH....GLEEKTKHQIRVVRSSLKAMVPEFLDIR......................------RIFEEEEFFFLSA....RKRLIDLATTLVERKILTEQL..............................
A0A0E2J2V1_CHLPS/9-206              ..s-RGCLAIYVFSIFLSVL.VLISSITA.LVLFSVELGVIPSIVLGMSVLVALFFLATSFYHIVNRKRHIQIESPQNESPshdalvh...................vandpilEDSVGALQCENQQIQELEREHVH..VSTRIPDLDSEVLRHEENQIRES....SFEARIQELEEALASSESQFRERVVCLE......................---SQLAELAQQKSEIERS....ALL------------------fegtlqqrdrnhhli...............
A0A0E2J222_CHLPS/23-193             ..f-KKQLLVRITLIAINVV.FIISHIVA.VTAFAS-LLPAFVFAISVTSIILGLILLGLGVKHIFSYFKKAKAVDSSTRD.................................--------EHQPTVQKLLAEIQD..LQNKALDYKNEATEMKNEYNSLLqgciEDRATYLSNEDAWRFENKELEACITELK......................-------------DYIAAL....QQMNEDCDTRLQEEQHM----hma...........................
A0A0E2J147_CHLPS/33-203             ..q-KNRLIISISILILALL.A-VIMIGG.FIAALFSPKGIYIGIAALISLLIGIILFPLII-TCSSKPPVAHIRPRDL--.................................-----DLSKLDVRYNRLLHETIK..EDEKKYAKEQEAKLQRRQRRSLR....TLPRRKQVKASSSDEVQKPRRRTSSVLN......................-------------------....---------------------lirprnssspssnsssldsddsssdhntqq
Q9JS25_CHLPN/1-184                  ...---------------ML.LLISGALF.LTLGIPGLTAGVSFGLGIGLSALGGVLVVSGLLCLLVKREVSKVCPEEIPAvqpeetpeg..............vpvtpfekpaLDEAQKEQKTQKILDQLPQELDQ..LDRYIQEVFACLGPLKDLKYEDQ....GFLQDVKEEFQVFDFVQKDMIAEFVELQqi..................lcQ------------------....---------------------egrllefvinqtryigrdlfkreds.....
Q9Z8V9_CHLPN/28-216                 ..q-CKSIAVIISLFALGML.LLCLGIIL.ISIPIPGLAAQVALGLGIVSLILGIALANIGFLCLLLRCKQVPQKPDTLPS.................................--ESSKQPSEGSTPTALPWQAGE..FLEKVQVSATPILLPKNKDEELS...aKVMKEGAEAASSIKQAVLESTEKLIDAR......................KQEESRREARKKIVAEEAE....ASRKRIQQQMAADQEALRKR-k.............................
A0A0E2J0K3_CHLPS/47-247             ..s-VLQRIFHLIKIISAVS.LFAVGIAA.LICLQ--FGVAVSTLSLVLMIAIMLVSFVIVIMVIQDSTPSQVARRMKQQLhqfsqent................rlhqevdtlVSANRDLANQISELTQLHEKLSD..FGNKLETCTGEFDELISEFKVNL....EAFKSVGTRVETIISPFERLAESLTGVF......................----SKDAVKNMVDAVSAL....RVEMETLKQHVEESRAVLQQL..............................
O84231_CHLTR/32-194                 .nt--CSKILDIALAIVGAL.VVVAGVLA.LVLCASN---VIFTAIGIAALIIGSACVGAGISRLMCRSSYASLEAKNVLA.................................----------EQRLRNLSEEKDA..LVSVSFINKMFLRGLTDDLQALE...aKAIEVEIDCLDRLEKNEQALLSDVRLVL......................-------------------....SSYTRWLDSAEKEKAAL----kasidanq......................
INCA1_CHLTR/24-223                  pqp----SLMDKIKKIAAIAsLILIGTIGfLALLGHLVGFLIAPQITIVLLALFIISLAGNALYLQKTANLHLYQDLQREV.................................----GSLKEINFMLSVLQKEFLH..LSKEFATTSKDLSAVSQDFYSCL....QGFRDNYKGFESLLDEYKNSTEEMRKLFsqeiia.........dlkgsvaSLREEIRFLTPLAEEVRRL....AHNQQSLTVVIEELKTIRDS-l.............................
Q9Z7W9_CHLPN/47-283                 ..g-WNHTIVKVSLIILALLtILGGGLLV.------GLLPAVPMFIGTGLIALGAVIFALALILCLYDSQGLPEELPPVPEpqqiqiedlrnetrevlegtllevllkdrdakdPAVPQVVVDCEKRLGMLDRKLRR..EEEILYRSTAHLKDEERYEFLLEl..lEMRSLVADRLEFNRRSYERFVQGIMTVRseegek.........eisrlqdLISLQQQTVQDLRSRIDDEqkrcWTALQRINQSQKDIQRAHDR-e.............................
Q9Z6K4_CHLPN/1-168                  ..m----------------L.FLISGALF.LTLGISGLSAAISFGLGIGLSALGGVLVVSGLLCLLAKREVPTVRPEEIPEgv............................svaPSEEPALQATQKTLAQLPKELDQ..LDRYIQEVVSCLGKLKDLRCEDQ....GLLKDAKEKLQVFDFVWKDMMTEFVELQ......................------QIMDQEGWYLKCL....IQEMR----------------digstlfmsq....................
Q9Z8Z8_CHLPN/32-228                 sfi---EKVIIVAKYILFAI.AATSGALG.TILG---LSGALTPGIGIALLV--IFFVSMVLLGLILKDSISGGEERRLREevsrftse.................nqrltvitTTLETEVKDLKAAKDQLTLEIEA..FRNENGNLKTTAEDLEEQVSKLSe.qlEALERINQLIQANAGDAQEISSELKKLIsgw................dskVVEQINTSIQALKVLLGQE....W--------------------vqeaqth.......................
Q9K1Z0_CHLPN/25-134                 ..m-RKLRILAIVLIALSII.LIAGGVVL.LTVAIPGLSSVISSPAGMGACALGCVMLALGIDVLLKKREVPIVLASVTTTpg............................tgsPRSGISISGADSTIRSLPTYLLD..EG---------------------....----------------------------......................-------------------....---------------------hpqs..........................
A0A0E2IZH6_CHLPS/1-206              ...------MSLTLIAVGII.LVISGILL.LTLTITSLPSAFSIALGATVLALGTSLASFGVALRILKKPRVNNEGEVVLAtelmnmkq................vveqkteevNRLQGEVSASQTQLAEISEALTT..TRELGNNLQSRLDESSELLTQSR....ENLGAVEARLQTTEETLSQKEEQLARSQ.....................gELQAEQAKVAQLEAQVRDLesqlQETSANLDRAIASQQDLMERL..............................
Q9K1Z0_CHLPN/135-243                ..m-RKLRILAIVLIVFSII.LIASGVVL.LTVAIPGLSSVISSPAGMGACALGCVMLALGIDVLLKKREVPIVLASVTTTpg............................tgsPRSGISISGADSTIRSLPTYPLD..-----------------------....----------------------------......................-------------------....---------------------eghpq.........................
Q9Z382_CHLPN/25-184                 .ds--KSRALGITLLVVGIL.LVVCGAIV.LSGVISGLSALIVCGLGISTISLGVVLFVLGLILLLRKRELTL--------.................................-----EQIEAKQIAETFADELKE..LEMYIQSTEKSLEKIEGSRYSDQ....GFLNRATQKILDLESSLSSITSEFRDLR......................------QLFDEEK------....---------------------iellsgerllefiaan..............
A0A0E2J214_CHLPS/25-227             ...SRVHVLTTIISLIASLL.IITGAIAA.VVLFGTQLGVLYSTVIIGISVAIGVLLFSASLKCFSCHAVISQSQRFSEDT.................................PRSHIHDSRPSEAPALTEESIDA..IERELRTLMSEHEQERLNHQYFV....SQRDLAKISMDSAREEFDNAYTDFQRFQellivg.........dcgnlvsDCQESLSRLREKSLNYARS....LQCYEDLLQQLHSHQDLID--fr............................
A0A0E2J210_CHLPS/28-235             ...SKYQRIATAIALLAGMV.LIGTLIGT.LVFFALPTSVTLVALVSTALLA-SVILLSMSMYNVVSQSRRVPGDARLGEE................................nTRLQAEMIELREQLICSEARLEE..ERGRCSELSVKLMSAIGDLAQAN....QEKASLESKVQALKELVASYPPIAEEAQkmqeelgkr....tlevalakqNIGALEEQVQSLETQLTHS....LEQVDALSAQKEELEACLQQ-l.............................
A0A0E2JEY4_CHLPS/22-207             .tn--SHIIINTIAIVSGIL.IIASSIAA.CVFLGADLGLLSAILLGMAIIA-GLLLIALGVYFCCQSSSPQQVTPSVIEQ.................................----ERVLELTQQLATANNELAS..LRLSNQENQIGIETSLSSISEEQ...rDLLQERCERIVQLDSIIHQLRKEHALLL......................ESKEEECYREVVRQTNLRL....QLDHRHQQEMESKERSIRER-t.............................
Q9K1Z3_CHLPN/1-173                  ..m-----------------.------LL.LTLGIPGLTAGISFGAGLGFSALGGVLVISGLLFLLVRREVPTVRSEEIPRgvsvt......................pseepaLEKAQKEPETKKILDRLPKELDQ..LDTYIQEVFACLERLKDPKYEDR....GLLTEAKEKLRVFDVVEKDMMSEFLDIQ......................------RVLNEEAYYVEHC....QDPLENIAYEIFSSQELRD--yy............................
Q9JRX6_CHLPN/1-171                  ..m-------------LGIL.LIASGIIF.LAVAIPGLSSAVALGLGCGMTALGTVLLITGLVLLIRSEKLAL--------.................................-----EQVEIKQARTRVNNELDQ..LSQYVFYTENVLDNLKRWSYRDL....GFVRQAQEEVTNLEQDIEEIFLTLRDIR......................------NALDNEEFFMTHA....KQCLAQ---------------vgeslfqdasidefinlahlseirqhl...
Q9K202_CHLPN/1-155                  ...---------------ML.LLISGALF.LTLGVPGLAAGLSFGLGIGLSALGGVLVVSGLLFFLIRRGVSKVRPEEIPV.................................----TPSHEAQKILCQLPQELDQ..LDTSIQEVVSCLGKLKDLKYEDQ....GLLTEVQEKLRVFDFVRKDMVTEFLELQ......................-------------QVVAQE....GQFLDYLINQVQS--------ishkl.........................
Q9K1Z4_CHLPN/1-167                  ...---------------ML.LLISGALF.LTLGIPGLSAAISFGLGIGLSALGGVLMISGLLCLLVKREIPTVRPEEIPEgv............................slaPSEEPALQAAQKTLAQLPKELDQ..LDTDIQEVFACLRKLKDSKYESR....SFLNDAKKELRVFDFVVEDTLSEIFELR......................------QIVAQEGWDL---....---------------------nflinggrslmmtaese.............
A0A0E2J1X5_CHLPS/23-139             ...SKYQRVANAIALLAGMA.LIGTLIGA.LVCFALPASLTLVALVSSSLLA-SVILLSISMYNLVSQSRRASSYAQIGKE................................nTRLRAEIIELKEKLAHPEARLEE..EQKIQSSNTS-------------....----------------------------......................-------------------....---------------------ssqsgsks......................
A0A0E2J2L4_CHLPS/25-209             ..p-HVVLITSIIAVILGLA.VITAGIAL.LVISHALSSAIFNGILISIVLGVTLILCIGGGHSCIILQLARLHRS-----.................................-----EVSGSENVIQELQTSSQD..LQNCLSEEDHPLQSQQNQEIEDAlqmqALLKSKQDELDSLTHRYAAMAQEHSYLE.....................nTVSRLRKELVELRRVLEEN....QATSQLVIEKLQVSNELLNK-e.............................
Q9Z8W9_CHLPN/27-213                 ..k-YKSLILSVSLIVLGVL.LLCVGMLL.LVNAIFS-FSVLTVGLGGAGVFLGSLLLILGLIFFVSYHRKLSEATRSLEQ.................................-----KITLEYQPWADLRKELNE..VQEWSNFLLDEWEDFKEVVAQHK....SQFATFEGDLLLFGREVEKYETIWKELDgrdvalltelkniwgpleflrkKGDRLQCE-----------....---------------------idklrkevmkvgk.................
Y288_CHLTR/32-214                   ..a-KAMRITGIALAALSLLaVVACVIAV.------SAGGAAIPLAVISGIAVMSGLLSAATIICSAKKALAQRKQKQLEE.................................---SLPLDNATEHVSYLTSDTSYfnQWESLGALNKQLSQIDLTIQAPEk..kLLKEVLGSRYDSINHSIEEISDRFTKML......................SLLRLREHFYRGEERYAPY....------LSPPLLNKNRLL---tqitsn........................
#=GC seq_cons                       .......hlhtlhhlhhull.llsuGllh.LslshssLuusluhslGhuhlALGslLlshGlhhllt+pphshhpspth.t......................................phpptpptlspLspElsp..hpp.htps.splpphcp.hhptp....thhpphppclpshctshpphhpchhclp............................p.h.p.t..h.t..........................h.............................
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