GenomeNet

Database: Pfam
Entry: Inhibitor_I34
LinkDB: Inhibitor_I34
Original site: Inhibitor_I34 
#=GF ID   Inhibitor_I34
#=GF AC   PF10466.7
#=GF DE   Saccharopepsin inhibitor I34
#=GF AU   Mistry J
#=GF SE   Manual
#=GF GA   25.00 25.00;
#=GF TC   31.10 30.80;
#=GF NC   24.40 24.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Protease_inhibitor_(biology)
#=GF RN   [1]
#=GF RM   15065849
#=GF RT   IA3, an aspartic proteinase inhibitor from Saccharomyces
#=GF RT   cerevisiae, is intrinsically unstructured in solution. 
#=GF RA   Green TB, Ganesh O, Perry K, Smith L, Phylip LH, Logan TM, Hagen
#=GF RA   SJ, Dunn BM, Edison AS; 
#=GF RL   Biochemistry. 2004;43:4071-4081.
#=GF DR   INTERPRO; IPR019507;
#=GF DR   MEROPS; I34;
#=GF CC   The saccharopepsin inhibitor is highly specific for the aspartic
#=GF CC   peptidase saccharopepsin.                  It is largely
#=GF CC   unstructured in the absence of saccharopepsin [1], but in the
#=GF CC   presence, the inhibitor undergoes a conformation change forming
#=GF CC   an almost perfect alpha-helix from Asn2 to Met32 in the active
#=GF CC   site cleft of the peptidase.
#=GF SQ   5
#=GS J6EDV1_SACK1/1-69  AC J6EDV1.1
#=GS IPA3_YEAST/1-68    AC P01094.1
#=GS IPA3_YEAST/1-68    DR PDB; 1DP5 B; 2-32;
#=GS IPA3_YEAST/1-68    DR PDB; 1G0V B; 3-31;
#=GS IPA3_YEAST/1-68    DR PDB; 1DPJ B; 3-31;
#=GS G0VEJ0_NAUCC/3-68  AC G0VEJ0.1
#=GS G8ZWK9_TORDC/1-58  AC G8ZWK9.1
#=GS J8Q6F5_SACAR/1-68  AC J8Q6F5.1
J6EDV1_SACK1/1-69             .MNTDQQKVNEIFQSSKEKLQGDAKVVNDAFKEMASKDKNGKDDNISDNTRKPDYQEQYNKLKGAGHRNE....
IPA3_YEAST/1-68               .MNTDQQKVSEIFQSSKEKLQGDAKVVSDAFKKMASQDKDGKTTD-ADESEKHNYQEQYNKLKGAGHKKE....
#=GR IPA3_YEAST/1-68    SS    .XXHHHHHHHHHHHHHHHHHHHHHHHHHHHHTXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXX....
G0VEJ0_NAUCC/3-68             dKNAN---VSEMFQQAKEMLEGKANAASEGMKNMASPESKEKMKTKGQDMEK-KAQDSYNKLRGAGKQE-q...
G8ZWK9_TORDC/1-58             m--------SDFFQQAKDKLTGDTNVANEHLKKLADKYPVNTEEQ---EQARARNEQAYQSLKQH-----kqqk
J8Q6F5_SACAR/1-68             .MNTDQQKVSDIFQSSKEKLQGDAKVVSDAFKEMAKKDKGGKADNISDK-DKPDYQEQYNKLKQSAHKKE....
#=GC SS_cons                  .XXHHHHHHHHHHHHHHHHHHHHHHHHHHHHTXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXX....
#=GC seq_cons                 .MNTDQQKVSEIFQSSKEKLQGDAKVVSDAFKcMASKDKsGKs-shuD-p-KscYQEQYNKLKGAGH+cE....
//
DBGET integrated database retrieval system