#=GF ID   Inhibitor_I34
#=GF AC   PF10466.4
#=GF DE   Saccharopepsin inhibitor I34
#=GF AU   Mistry J
#=GF SE   Manual
#=GF GA   25.00 25.00;
#=GF TC   26.10 39.40;
#=GF NC   21.40 21.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Protease_inhibitor_(biology)
#=GF RN   [1]
#=GF RM   15065849
#=GF RT   IA3, an aspartic proteinase inhibitor from Saccharomyces
#=GF RT   cerevisiae, is intrinsically unstructured in solution. 
#=GF RA   Green TB, Ganesh O, Perry K, Smith L, Phylip LH, Logan TM, Hagen
#=GF RA   SJ, Dunn BM, Edison AS; 
#=GF RL   Biochemistry. 2004;43:4071-4081.
#=GF DR   INTERPRO; IPR019507;
#=GF DR   MEROPS; I34;
#=GF CC   The saccharopepsin inhibitor is highly specific for the aspartic
#=GF CC   peptidase saccharopepsin.	     It is largely unstructured in
#=GF CC   the absence of saccharopepsin [1], but in the presence, the
#=GF CC   inhibitor undergoes a conformation change forming an almost
#=GF CC   perfect alpha-helix from Asn2 to Met32 in the active site cleft
#=GF CC   of the peptidase.
#=GF SQ   7
#=GS IPA3_YEAST/1-68    AC P01094.1
#=GS IPA3_YEAST/1-68    DR PDB; 1DP5 B; 2-32;
#=GS IPA3_YEAST/1-68    DR PDB; 1G0V B; 3-31;
#=GS IPA3_YEAST/1-68    DR PDB; 1DPJ B; 3-31;
#=GS C7GTS7_YEAS2/1-68  AC C7GTS7.1
#=GS A6ZMN3_YEAS7/1-68  AC A6ZMN3.1
#=GS G2WKM7_YEASK/1-68  AC G2WKM7.1
#=GS C8ZF36_YEAS8/1-68  AC C8ZF36.1
#=GS B3LM60_YEAS1/1-68  AC B3LM60.1
#=GS G0VEJ0_NAUCC/1-71  AC G0VEJ0.1
IPA3_YEAST/1-68               ...MNTDQQKVSEIFQSSKEKLQGDAKVVSDAFKKMASQD.KDGKTTDADESEKHNYQEQYNKLKGAGHKKE.....
#=GR IPA3_YEAST/1-68    SS    ...XXHHHHHHHHHHHHHHHHHHHHHHHHHHHHTXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.....
C7GTS7_YEAS2/1-68             ...MNTDQQKVSEIFQSSKEKLQGDAKVVSDAFKKMASQD.KDGKTTDADESEKHNYQEQYNKLKGAGHKKE.....
A6ZMN3_YEAS7/1-68             ...MNTDQQKVSEIFQSSKEKLQGDAKVVSDAFKKMASQD.KDGKTTDADESEKHNYQEQYNKLKGAGHKKE.....
G2WKM7_YEASK/1-68             ...MNTDQQKVSEIFQSSKEKLQGDAKVVSDAFKKMASQD.KDGKTTNADESEKHNYQEQYNKLKGAGHKKE.....
C8ZF36_YEAS8/1-68             ...MNTDQQKVSEIFQSSKEKLQGDAKVVSDAFKKMASQD.KDGKTTDADESEKHNYQEQYNKLKGAGHKKE.....
B3LM60_YEAS1/1-68             ...MNTDQQKVSEIFQSSKEKLQGDAKVVSDAFKKMASQD.KDGKTTDADESEKHNYQEQYNKLKGAGHKKE.....
G0VEJ0_NAUCC/1-71             msd---KNANVSEMFQQAKEMLEGKANAASEGMKNMASPEsKEKMKTKGQDMEKK-AQDSYNKLRGAGKQ--eqtke
#=GC SS_cons                  ...XXHHHHHHHHHHHHHHHHHHHHHHHHHHHHTXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.....
#=GC seq_cons                 ...MNTDQQKVSEIFQSSKEKLQGDAKVVSDAFKKMASQD.KDGKTTDADESEKHNYQEQYNKLKGAGHKKE.....
//