#=GF ID Internalin_N
#=GF AC PF12354.7
#=GF DE Bacterial adhesion/invasion protein N terminal
#=GF AU Gavin OL
#=GF SE Prosite
#=GF GA 24.10 24.10;
#=GF TC 28.80 27.80;
#=GF NC 23.40 23.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 12526809
#=GF RT Structure of internalin, a major invasion protein of Listeria
#=GF RT monocytogenes, in complex with its human receptor E-cadherin.
#=GF RA Schubert WD, Urbanke C, Ziehm T, Beier V, Machner MP, Domann E,
#=GF RA Wehland J, Chakraborty T, Heinz DW;
#=GF RL Cell 2002;111:825-836.
#=GF CC This domain family is found in bacteria, and is approximately 60
#=GF CC amino acids in length. The family is found in association with
#=GF CC Pfam:PF00560, Pfam:PF08191, Pfam:PF09479. There are two
#=GF CC completely conserved residues (I and F) that may be functionally
#=GF CC important. Internalin mediates bacterial adhesion and invasion
#=GF CC of epithelial cells in the human intestine through specific
#=GF CC interaction with its host cell receptor E-cadherin. This family
#=GF CC is the N terminal of internalin, the cap domain of the protein.
#=GF CC The cap domain is conserved between different internalin types.
#=GF CC The cap domain does not interact with E cadherin, therefore its
#=GF CC function is presumably structural: capping the hydrophobic core.
#=GF SQ 13
#=GS Q8Y9W0_LISMO/2-59 AC Q8Y9W0.1
#=GS Q8Y5N0_LISMO/1-55 AC Q8Y5N0.1
#=GS Q8Y8U2_LISMO/1-57 AC Q8Y8U2.1
#=GS Q8Y6A8_LISMO/1-56 AC Q8Y6A8.1
#=GS Q8Y6A8_LISMO/1-56 DR PDB; 4CC4 C; 35-57;
#=GS Q8Y6A8_LISMO/1-56 DR PDB; 1XEU A; 35-57;
#=GS Q8Y6A8_LISMO/1-56 DR PDB; 4CC4 E; 35-57;
#=GS Q8Y6A8_LISMO/1-56 DR PDB; 4CC4 A; 35-57;
#=GS A0A0R2FR41_9LACT/2-57 AC A0A0R2FR41.1
#=GS INLA_LISMO/3-58 AC P0DJM0.1
#=GS INLA_LISMO/3-58 DR PDB; 2OMV A; 36-58;
#=GS INLA_LISMO/3-58 DR PDB; 2OMZ A; 36-58;
#=GS INLA_LISMO/3-58 DR PDB; 2OMW A; 36-58;
#=GS INLA_LISMO/3-58 DR PDB; 1O6S A; 36-58;
#=GS INLA_LISMO/3-58 DR PDB; 1O6T A; 36-58;
#=GS INLA_LISMO/3-58 DR PDB; 2OMY A; 36-58;
#=GS INLA_LISMO/3-58 DR PDB; 1O6V A; 36-58;
#=GS INLA_LISMO/3-58 DR PDB; 1O6V B; 36-58;
#=GS Q8Y7Y3_LISMO/1-58 AC Q8Y7Y3.1
#=GS Q7AP88_LISMO/3-58 AC Q7AP88.1
#=GS W7C475_9LIST/2-57 AC W7C475.1
#=GS Q7AP86_LISMO/2-56 AC Q7AP86.1
#=GS Q8Y4H2_LISMO/1-55 AC Q8Y4H2.1
#=GS INLB_LISMO/3-58 AC P25147.2
#=GS INLB_LISMO/3-58 DR PDB; 2UZY A; 36-58;
#=GS INLB_LISMO/3-58 DR PDB; 2WQU D; 37-58;
#=GS INLB_LISMO/3-58 DR PDB; 4AW4 C; 36-58;
#=GS INLB_LISMO/3-58 DR PDB; 1D0B A; 36-58;
#=GS INLB_LISMO/3-58 DR PDB; 4AW4 B; 36-58;
#=GS INLB_LISMO/3-58 DR PDB; 2WQU C; 36-58;
#=GS INLB_LISMO/3-58 DR PDB; 2WQW A; 36-58;
#=GS INLB_LISMO/3-58 DR PDB; 2WQU B; 36-58;
#=GS INLB_LISMO/3-58 DR PDB; 2WQU E; 37-58;
#=GS INLB_LISMO/3-58 DR PDB; 2WQW B; 36-58;
#=GS INLB_LISMO/3-58 DR PDB; 1OTO A; 36-58;
#=GS INLB_LISMO/3-58 DR PDB; 4AW4 A; 36-58;
#=GS INLB_LISMO/3-58 DR PDB; 2WQV B; 37-58;
#=GS INLB_LISMO/3-58 DR PDB; 2WQV A; 37-58;
#=GS INLB_LISMO/3-58 DR PDB; 1M9S A; 36-58;
#=GS INLB_LISMO/3-58 DR PDB; 2UZX C; 36-58;
#=GS INLB_LISMO/3-58 DR PDB; 2WQU A; 36-58;
#=GS INLB_LISMO/3-58 DR PDB; 2WQX A; 36-58;
#=GS INLB_LISMO/3-58 DR PDB; 2WQX B; 36-58;
#=GS INLB_LISMO/3-58 DR PDB; 2UZX A; 36-58;
#=GS INLB_LISMO/3-58 DR PDB; 1H6T A; 36-58;
#=GS INLB_LISMO/3-58 DR PDB; 1OTM A; 36-58;
#=GS INLB_LISMO/3-58 DR PDB; 1OTN A; 36-58;
#=GS INLB_LISMO/3-58 DR PDB; 2WQU F; 37-58;
#=GS INLB_LISMO/3-58 DR PDB; 2Y5Q A; 36-58;
#=GS INLB_LISMO/3-58 DR PDB; 2UZY C; 36-58;
#=GS Q7AP87_LISMO/3-58 AC Q7AP87.1
Q8Y9W0_LISMO/2-59 .........KSKNNYFKQITTIMTVVSLLIMVLGIQG....nNDVKAAP..QVAP.PASINQIFPDADLAEGIR.
Q8Y5N0_LISMO/1-55 .......mk-------KILTGLSTTLLLTVLLLTITG.....GDLKAKAasDLYPlPAPIIDVFPDEGLAKDMA.
Q8Y8U2_LISMO/1-57 .........------MKKLCTVILFLTLLLNGFVPNAha.ktESPSADNnlQVAP.PAAIKDLFPDPAMANEV-l
Q8Y6A8_LISMO/1-56 .........MKKNNWLQNAVIAMLVLIVGLCINMGSG.....TKVQAE-..SIQR.PTPINQVFPDPGLANAVK.
#=GR Q8Y6A8_LISMO/1-56 SS .........XXXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXXXX--..--SS.-EEHHHHS-SHHHHHHHH.
A0A0R2FR41_9LACT/2-57 ..kkggekm---------VKKIWLALCVVLAVVMMSTv...aSPVQAA-..ILAE.PRKISEIFPDDNFAQTVA.
INLA_LISMO/3-58 .........KKRYVWLKSILVAILVFGSGVWINTSNG.....TNAQAA-..TITQ.DTPINQIFTDTALAEKMK.
#=GR INLA_LISMO/3-58 SS .........XXXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXXXX--..S-SS.-EEHHHHS-SHHHHHHHH.
Q8Y7Y3_LISMO/1-58 .........------MKKTIKITTSLLLSFACVFSIGdftkpHTVEAEIvySLTN.PKPVNEIFTDPKLAQVVA.
Q7AP88_LISMO/3-58 .........QRKTSVLHVLLVVTAILGISLWVNASHG.....MKAQAE-..SIAQ.PAPINEIFTDPALADEVK.
W7C475_9LIST/2-57 khlknglkl----------------LICIVIVFGSIGls.tsTEVTAESplSATL.PAPINQVFPDAALAQVIA.
Q7AP86_LISMO/2-56 .........KRNKTALRILVTLAVVLAITFWVGMSSK.....-EVQAA-..VIEH.PTPINEIFTDPVLTDNVK.
Q8Y4H2_LISMO/1-55 ........m------RKVLMFLSTALLLAILSLSFTG.....LDLKAKAasDLYPlPAPIIDVFPDDGLAKDMA.
INLB_LISMO/3-58 ........e-KHNPRRKYCLISGLAIIFSLWIIIGNG.....AKVQAE-..TITV.PTPIKQIFSDDAFAETIK.
#=GR INLB_LISMO/3-58 SS ........X-XXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXXXXS-..S-SS.-EEHHHHSSSHHHHHHHH.
Q7AP87_LISMO/3-58 .........KRWNSVFKLVLMVTAILGLSLYVTTSQG.....VEVRAE-..SITQ.PTAINVIFPDPALANAIK.
#=GC SS_cons ........X-XXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXXXXS-..S-SS.-EEHHHHSSSHHHHHHHH.
#=GC seq_cons ...............hKhlhhlhhsLhlslhlhsusG.....scVpAc...sls..PsPINpIFPDsuLApslt.
//
