GenomeNet

Database: Pfam
Entry: Internalin_N
LinkDB: Internalin_N
Original site: Internalin_N 
#=GF ID   Internalin_N
#=GF AC   PF12354.7
#=GF DE   Bacterial adhesion/invasion protein N terminal
#=GF AU   Gavin OL
#=GF SE   Prosite
#=GF GA   24.10 24.10;
#=GF TC   28.80 27.80;
#=GF NC   23.40 23.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   12526809
#=GF RT   Structure of internalin, a major invasion protein of Listeria
#=GF RT   monocytogenes, in complex with its human receptor E-cadherin. 
#=GF RA   Schubert WD, Urbanke C, Ziehm T, Beier V, Machner MP, Domann E,
#=GF RA   Wehland J, Chakraborty T, Heinz DW; 
#=GF RL   Cell 2002;111:825-836.
#=GF CC   This domain family is found in bacteria, and is approximately 60
#=GF CC   amino acids in length. The family is found in association with
#=GF CC   Pfam:PF00560, Pfam:PF08191, Pfam:PF09479. There are two
#=GF CC   completely conserved residues (I and F) that may be functionally
#=GF CC   important. Internalin mediates bacterial adhesion and invasion
#=GF CC   of epithelial cells in the human intestine through specific
#=GF CC   interaction with its host cell receptor E-cadherin. This family
#=GF CC   is the N terminal of internalin, the cap domain of the protein.
#=GF CC   The cap domain is conserved between different internalin types.
#=GF CC   The cap domain does not interact with E cadherin, therefore its
#=GF CC   function is presumably structural: capping the hydrophobic core.
#=GF SQ   13
#=GS Q8Y9W0_LISMO/2-59      AC Q8Y9W0.1
#=GS Q8Y5N0_LISMO/1-55      AC Q8Y5N0.1
#=GS Q8Y8U2_LISMO/1-57      AC Q8Y8U2.1
#=GS Q8Y6A8_LISMO/1-56      AC Q8Y6A8.1
#=GS Q8Y6A8_LISMO/1-56      DR PDB; 4CC4 C; 35-57;
#=GS Q8Y6A8_LISMO/1-56      DR PDB; 1XEU A; 35-57;
#=GS Q8Y6A8_LISMO/1-56      DR PDB; 4CC4 E; 35-57;
#=GS Q8Y6A8_LISMO/1-56      DR PDB; 4CC4 A; 35-57;
#=GS A0A0R2FR41_9LACT/2-57  AC A0A0R2FR41.1
#=GS INLA_LISMO/3-58        AC P0DJM0.1
#=GS INLA_LISMO/3-58        DR PDB; 2OMV A; 36-58;
#=GS INLA_LISMO/3-58        DR PDB; 2OMZ A; 36-58;
#=GS INLA_LISMO/3-58        DR PDB; 2OMW A; 36-58;
#=GS INLA_LISMO/3-58        DR PDB; 1O6S A; 36-58;
#=GS INLA_LISMO/3-58        DR PDB; 1O6T A; 36-58;
#=GS INLA_LISMO/3-58        DR PDB; 2OMY A; 36-58;
#=GS INLA_LISMO/3-58        DR PDB; 1O6V A; 36-58;
#=GS INLA_LISMO/3-58        DR PDB; 1O6V B; 36-58;
#=GS Q8Y7Y3_LISMO/1-58      AC Q8Y7Y3.1
#=GS Q7AP88_LISMO/3-58      AC Q7AP88.1
#=GS W7C475_9LIST/2-57      AC W7C475.1
#=GS Q7AP86_LISMO/2-56      AC Q7AP86.1
#=GS Q8Y4H2_LISMO/1-55      AC Q8Y4H2.1
#=GS INLB_LISMO/3-58        AC P25147.2
#=GS INLB_LISMO/3-58        DR PDB; 2UZY A; 36-58;
#=GS INLB_LISMO/3-58        DR PDB; 2WQU D; 37-58;
#=GS INLB_LISMO/3-58        DR PDB; 4AW4 C; 36-58;
#=GS INLB_LISMO/3-58        DR PDB; 1D0B A; 36-58;
#=GS INLB_LISMO/3-58        DR PDB; 4AW4 B; 36-58;
#=GS INLB_LISMO/3-58        DR PDB; 2WQU C; 36-58;
#=GS INLB_LISMO/3-58        DR PDB; 2WQW A; 36-58;
#=GS INLB_LISMO/3-58        DR PDB; 2WQU B; 36-58;
#=GS INLB_LISMO/3-58        DR PDB; 2WQU E; 37-58;
#=GS INLB_LISMO/3-58        DR PDB; 2WQW B; 36-58;
#=GS INLB_LISMO/3-58        DR PDB; 1OTO A; 36-58;
#=GS INLB_LISMO/3-58        DR PDB; 4AW4 A; 36-58;
#=GS INLB_LISMO/3-58        DR PDB; 2WQV B; 37-58;
#=GS INLB_LISMO/3-58        DR PDB; 2WQV A; 37-58;
#=GS INLB_LISMO/3-58        DR PDB; 1M9S A; 36-58;
#=GS INLB_LISMO/3-58        DR PDB; 2UZX C; 36-58;
#=GS INLB_LISMO/3-58        DR PDB; 2WQU A; 36-58;
#=GS INLB_LISMO/3-58        DR PDB; 2WQX A; 36-58;
#=GS INLB_LISMO/3-58        DR PDB; 2WQX B; 36-58;
#=GS INLB_LISMO/3-58        DR PDB; 2UZX A; 36-58;
#=GS INLB_LISMO/3-58        DR PDB; 1H6T A; 36-58;
#=GS INLB_LISMO/3-58        DR PDB; 1OTM A; 36-58;
#=GS INLB_LISMO/3-58        DR PDB; 1OTN A; 36-58;
#=GS INLB_LISMO/3-58        DR PDB; 2WQU F; 37-58;
#=GS INLB_LISMO/3-58        DR PDB; 2Y5Q A; 36-58;
#=GS INLB_LISMO/3-58        DR PDB; 2UZY C; 36-58;
#=GS Q7AP87_LISMO/3-58      AC Q7AP87.1
Q8Y9W0_LISMO/2-59                 .........KSKNNYFKQITTIMTVVSLLIMVLGIQG....nNDVKAAP..QVAP.PASINQIFPDADLAEGIR.
Q8Y5N0_LISMO/1-55                 .......mk-------KILTGLSTTLLLTVLLLTITG.....GDLKAKAasDLYPlPAPIIDVFPDEGLAKDMA.
Q8Y8U2_LISMO/1-57                 .........------MKKLCTVILFLTLLLNGFVPNAha.ktESPSADNnlQVAP.PAAIKDLFPDPAMANEV-l
Q8Y6A8_LISMO/1-56                 .........MKKNNWLQNAVIAMLVLIVGLCINMGSG.....TKVQAE-..SIQR.PTPINQVFPDPGLANAVK.
#=GR Q8Y6A8_LISMO/1-56      SS    .........XXXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXXXX--..--SS.-EEHHHHS-SHHHHHHHH.
A0A0R2FR41_9LACT/2-57             ..kkggekm---------VKKIWLALCVVLAVVMMSTv...aSPVQAA-..ILAE.PRKISEIFPDDNFAQTVA.
INLA_LISMO/3-58                   .........KKRYVWLKSILVAILVFGSGVWINTSNG.....TNAQAA-..TITQ.DTPINQIFTDTALAEKMK.
#=GR INLA_LISMO/3-58        SS    .........XXXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXXXX--..S-SS.-EEHHHHS-SHHHHHHHH.
Q8Y7Y3_LISMO/1-58                 .........------MKKTIKITTSLLLSFACVFSIGdftkpHTVEAEIvySLTN.PKPVNEIFTDPKLAQVVA.
Q7AP88_LISMO/3-58                 .........QRKTSVLHVLLVVTAILGISLWVNASHG.....MKAQAE-..SIAQ.PAPINEIFTDPALADEVK.
W7C475_9LIST/2-57                 khlknglkl----------------LICIVIVFGSIGls.tsTEVTAESplSATL.PAPINQVFPDAALAQVIA.
Q7AP86_LISMO/2-56                 .........KRNKTALRILVTLAVVLAITFWVGMSSK.....-EVQAA-..VIEH.PTPINEIFTDPVLTDNVK.
Q8Y4H2_LISMO/1-55                 ........m------RKVLMFLSTALLLAILSLSFTG.....LDLKAKAasDLYPlPAPIIDVFPDDGLAKDMA.
INLB_LISMO/3-58                   ........e-KHNPRRKYCLISGLAIIFSLWIIIGNG.....AKVQAE-..TITV.PTPIKQIFSDDAFAETIK.
#=GR INLB_LISMO/3-58        SS    ........X-XXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXXXXS-..S-SS.-EEHHHHSSSHHHHHHHH.
Q7AP87_LISMO/3-58                 .........KRWNSVFKLVLMVTAILGLSLYVTTSQG.....VEVRAE-..SITQ.PTAINVIFPDPALANAIK.
#=GC SS_cons                      ........X-XXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXXXXS-..S-SS.-EEHHHHSSSHHHHHHHH.
#=GC seq_cons                     ...............hKhlhhlhhsLhlslhlhsusG.....scVpAc...sls..PsPINpIFPDsuLApslt.
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