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Database: Pfam
Entry: Internalin_N
LinkDB: Internalin_N
Original site: Internalin_N 
#=GF ID   Internalin_N
#=GF AC   PF12354.6
#=GF DE   Bacterial adhesion/invasion protein N terminal
#=GF AU   Gavin OL
#=GF SE   Prosite
#=GF GA   24.10 24.10;
#=GF TC   58.90 58.10;
#=GF NC   23.40 23.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   12526809
#=GF RT   Structure of internalin, a major invasion protein of Listeria
#=GF RT   monocytogenes, in complex with its human receptor E-cadherin. 
#=GF RA   Schubert WD, Urbanke C, Ziehm T, Beier V, Machner MP, Domann E,
#=GF RA   Wehland J, Chakraborty T, Heinz DW; 
#=GF RL   Cell 2002;111:825-836.
#=GF CC   This domain family is found in bacteria, and is approximately 60
#=GF CC   amino acids in length. The family is found in association with
#=GF CC   Pfam:PF00560, Pfam:PF08191, Pfam:PF09479. There are two
#=GF CC   completely conserved residues (I and F) that may be functionally
#=GF CC   important. Internalin mediates bacterial adhesion and invasion
#=GF CC   of epithelial cells in the human intestine through specific
#=GF CC   interaction with its host cell receptor E-cadherin. This family
#=GF CC   is the N terminal of internalin, the cap domain of the protein.
#=GF CC   The cap domain is conserved between different internalin types.
#=GF CC   The cap domain does not interact with E cadherin, therefore its
#=GF CC   function is presumably structural: capping the hydrophobic core.
#=GF SQ   11
#=GS Q8Y9W0_LISMO/2-59  AC Q8Y9W0.1
#=GS Q8Y5N0_LISMO/1-55  AC Q8Y5N0.1
#=GS Q8Y8U2_LISMO/1-57  AC Q8Y8U2.1
#=GS Q8Y6A8_LISMO/1-56  AC Q8Y6A8.1
#=GS Q8Y6A8_LISMO/1-56  DR PDB; 4CC4 C; 35-57;
#=GS Q8Y6A8_LISMO/1-56  DR PDB; 1XEU A; 35-57;
#=GS Q8Y6A8_LISMO/1-56  DR PDB; 4CC4 E; 35-57;
#=GS Q8Y6A8_LISMO/1-56  DR PDB; 4CC4 A; 35-57;
#=GS INLA_LISMO/3-58    AC P0DJM0.1
#=GS INLA_LISMO/3-58    DR PDB; 2OMV A; 36-58;
#=GS INLA_LISMO/3-58    DR PDB; 2OMZ A; 36-58;
#=GS INLA_LISMO/3-58    DR PDB; 2OMW A; 36-58;
#=GS INLA_LISMO/3-58    DR PDB; 1O6S A; 36-58;
#=GS INLA_LISMO/3-58    DR PDB; 1O6T A; 36-58;
#=GS INLA_LISMO/3-58    DR PDB; 2OMY A; 36-58;
#=GS INLA_LISMO/3-58    DR PDB; 1O6V A; 36-58;
#=GS INLA_LISMO/3-58    DR PDB; 1O6V B; 36-58;
#=GS Q8Y7Y3_LISMO/1-58  AC Q8Y7Y3.1
#=GS Q7AP88_LISMO/3-58  AC Q7AP88.1
#=GS Q7AP86_LISMO/2-56  AC Q7AP86.1
#=GS Q8Y4H2_LISMO/1-55  AC Q8Y4H2.1
#=GS INLB_LISMO/3-58    AC P25147.2
#=GS INLB_LISMO/3-58    DR PDB; 2UZY A; 36-58;
#=GS INLB_LISMO/3-58    DR PDB; 2WQU D; 37-58;
#=GS INLB_LISMO/3-58    DR PDB; 4AW4 C; 36-58;
#=GS INLB_LISMO/3-58    DR PDB; 1D0B A; 36-58;
#=GS INLB_LISMO/3-58    DR PDB; 4AW4 B; 36-58;
#=GS INLB_LISMO/3-58    DR PDB; 2WQU C; 36-58;
#=GS INLB_LISMO/3-58    DR PDB; 2WQW A; 36-58;
#=GS INLB_LISMO/3-58    DR PDB; 2WQU E; 37-58;
#=GS INLB_LISMO/3-58    DR PDB; 2WQU B; 36-58;
#=GS INLB_LISMO/3-58    DR PDB; 2WQW B; 36-58;
#=GS INLB_LISMO/3-58    DR PDB; 1OTO A; 36-58;
#=GS INLB_LISMO/3-58    DR PDB; 4AW4 A; 36-58;
#=GS INLB_LISMO/3-58    DR PDB; 2WQV B; 37-58;
#=GS INLB_LISMO/3-58    DR PDB; 2WQV A; 37-58;
#=GS INLB_LISMO/3-58    DR PDB; 1M9S A; 36-58;
#=GS INLB_LISMO/3-58    DR PDB; 2UZX C; 36-58;
#=GS INLB_LISMO/3-58    DR PDB; 2WQU A; 36-58;
#=GS INLB_LISMO/3-58    DR PDB; 2WQX A; 36-58;
#=GS INLB_LISMO/3-58    DR PDB; 2WQX B; 36-58;
#=GS INLB_LISMO/3-58    DR PDB; 2UZX A; 36-58;
#=GS INLB_LISMO/3-58    DR PDB; 1H6T A; 36-58;
#=GS INLB_LISMO/3-58    DR PDB; 1OTM A; 36-58;
#=GS INLB_LISMO/3-58    DR PDB; 1OTN A; 36-58;
#=GS INLB_LISMO/3-58    DR PDB; 2WQU F; 37-58;
#=GS INLB_LISMO/3-58    DR PDB; 2Y5Q A; 36-58;
#=GS INLB_LISMO/3-58    DR PDB; 2UZY C; 36-58;
#=GS Q7AP87_LISMO/3-58  AC Q7AP87.1
Q8Y9W0_LISMO/2-59             ..KSKNNYFKQITTIMTVVSLLIMVLGIQG....nNDVKAAP..QVAP.PASINQIFPDADLAEGIR.
Q8Y5N0_LISMO/1-55             mk-------KILTGLSTTLLLTVLLLTITG.....GDLKAKAasDLYPlPAPIIDVFPDEGLAKDMA.
Q8Y8U2_LISMO/1-57             ..------MKKLCTVILFLTLLLNGFVPNAha.ktESPSADNnlQVAP.PAAIKDLFPDPAMANEV-l
Q8Y6A8_LISMO/1-56             ..MKKNNWLQNAVIAMLVLIVGLCINMGSG.....TKVQAE-..SIQR.PTPINQVFPDPGLANAVK.
#=GR Q8Y6A8_LISMO/1-56  SS    ..XXXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXXXX--..--SS.-EEHHHHS-SHHHHHHHH.
INLA_LISMO/3-58               ..KKRYVWLKSILVAILVFGSGVWINTSNG.....TNAQAA-..TITQ.DTPINQIFTDTALAEKMK.
#=GR INLA_LISMO/3-58    SS    ..XXXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXXXX--..S-SS.-EEHHHHS-SHHHHHHHH.
Q8Y7Y3_LISMO/1-58             ..------MKKTIKITTSLLLSFACVFSIGdftkpHTVEAEIvySLTN.PKPVNEIFTDPKLAQVVA.
Q7AP88_LISMO/3-58             ..QRKTSVLHVLLVVTAILGISLWVNASHG.....MKAQAE-..SIAQ.PAPINEIFTDPALADEVK.
Q7AP86_LISMO/2-56             ..KRNKTALRILVTLAVVLAITFWVGMSSK.....-EVQAA-..VIEH.PTPINEIFTDPVLTDNVK.
Q8Y4H2_LISMO/1-55             .m------RKVLMFLSTALLLAILSLSFTG.....LDLKAKAasDLYPlPAPIIDVFPDDGLAKDMA.
INLB_LISMO/3-58               .e-KHNPRRKYCLISGLAIIFSLWIIIGNG.....AKVQAE-..TITV.PTPIKQIFSDDAFAETIK.
#=GR INLB_LISMO/3-58    SS    .X-XXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXXXXS-..S-SS.-EEHHHHSSSHHHHHHHH.
Q7AP87_LISMO/3-58             ..KRWNSVFKLVLMVTAILGLSLYVTTSQG.....VEVRAE-..SITQ.PTAINVIFPDPALANAIK.
#=GC SS_cons                  .X-XXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXXXXS-..S-SS.-EEHHHHSSSHHHHHHHH.
#=GC seq_cons                 ...p..shhKhllhlsssLhlulhlhsusG.....tclpAc...sls..PsPINpIFsDsuLAcsl+.
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