#=GF ID   Ion_trans
#=GF AC   PF00520.26
#=GF DE   Ion transport protein
#=GF PI   ion_trans; 
#=GF AU   Finn RD
#=GF SE   Pfam-B_33 (release 1.0)
#=GF GA   20.80 20.80;
#=GF TC   20.80 20.80;
#=GF NC   20.70 20.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Ion_channel_family
#=GF DR   INTERPRO; IPR005821;
#=GF DR   PRINTS; PR00167;
#=GF DC   calcium channel signature
#=GF DR   PRINTS; PR00169;
#=GF DC   potassium channel signature
#=GF DR   PRINTS; PR00170;
#=GF DC   sodium channel signature
#=GF DR   SCOP; 1bl8; fa;
#=GF DR   TC; 1.A.3;
#=GF DR   TC; 1.A.4;
#=GF CC   This family contains Sodium, Potassium, Calcium ion channels.
#=GF CC   This family is 6 transmembrane helices in which the last two
#=GF CC   helices flank a loop which determines ion selectivity. In some
#=GF CC   sub-families (e.g. Na channels) the domain is  repeated four
#=GF CC   times, whereas in others (e.g. K channels) the protein forms as
#=GF CC   a tetramer in the membrane. A bacterial structure of the protein
#=GF CC   is known for the last two helices but is not the Pfam family due
#=GF CC   to it lacking the first four helices
#=GF SQ   20399
#=GS Q5SVK0_HUMAN/153-324    AC Q5SVK0.1
#=GS H3D165_TETNG/1145-1377  AC H3D165.1
#=GS A5I9E7_CULQU/168-415    AC A5I9E7.1
#=GS Q06AY5_CAEEL/1234-1452  AC Q06AY5.1
#=GS E5DMN6_9TELE/12-201     AC E5DMN6.1
#=GS H3DC93_TETNG/97-339     AC H3DC93.1
#=GS H0VIT6_CAVPO/1259-1483  AC H0VIT6.1
#=GS B4LKB4_DROVI/111-295    AC B4LKB4.1
#=GS A8JF89_CHLRE/435-711    AC A8JF89.1
#=GS Q54SN2_DICDI/100-182    AC Q54SN2.1
#=GS CAC1S_MOUSE/466-660     AC Q02789.2
#=GS A5I9E6_CULQU/1351-1573  AC A5I9E6.1
#=GS H3CJ10_TETNG/86-280     AC H3CJ10.1
#=GS H2V8U2_TAKRU/377-602    AC H2V8U2.1
#=GS H9FMC4_MACMU/1-126      AC H9FMC4.1
#=GS G0W9U4_NAUDC/1209-1437  AC G0W9U4.1
#=GS G3S2T5_GORGO/130-349    AC G3S2T5.1
#=GS D2GYC8_AILME/2-245      AC D2GYC8.1
#=GS H9FBT7_MACMU/35-245     AC H9FBT7.1
#=GS Q32UL4_BRARP/93-295     AC Q32UL4.1
#=GS Q19R15_HUMAN/119-394    AC Q19R15.1
#=GS E9G142_DAPPU/456-632    AC E9G142.1
#=GS H2Z8F5_CIOSA/403-638    AC H2Z8F5.1
#=GS H2SUL8_TAKRU/1181-1411  AC H2SUL8.1
#=GS E9KTM3_9ACAR/911-1061   AC E9KTM3.1
#=GS G3S767_GORGO/88-333     AC G3S767.1
#=GS A0E2S7_PARTE/234-429    AC A0E2S7.1
#=GS E9H9P2_DAPPU/2181-2374  AC E9H9P2.1
#=GS E0CYZ3_MOUSE/32-312     AC E0CYZ3.1
#=GS F6XAX4_MONDO/792-1005   AC F6XAX4.1
#=GS G3U3A7_LOXAF/73-321     AC G3U3A7.1
#=GS G3R3Q0_GORGO/159-363    AC G3R3Q0.1
#=GS I1MKJ7_SOYBN/55-324     AC I1MKJ7.1
#=GS H9EXS8_MACMU/141-228    AC H9EXS8.1
#=GS E9GJ26_DAPPU/869-1076   AC E9GJ26.1
#=GS H3G2D1_PRIPA/50-123     AC H3G2D1.1
#=GS B7QM66_IXOSC/238-417    AC B7QM66.1
#=GS C9SJY0_VERA1/284-618    AC C9SJY0.1
#=GS H3NEK5_9LACT/48-228     AC H3NEK5.1
#=GS H2VE58_TAKRU/572-761    AC H2VE58.1
#=GS CAC1C_CAVPO/7-169       AC O35505.1
#=GS F0YJE2_AURAN/137-355    AC F0YJE2.1
#=GS G3R265_GORGO/224-405    AC G3R265.1
#=GS F4W5P4_ACREC/541-778    AC F4W5P4.1
#=GS F6ZFT5_ORNAN/487-678    AC F6ZFT5.1
#=GS E1BNL5_BOVIN/1564-1774  AC E1BNL5.1
#=GS H9FU37_MACMU/2302-2558  AC H9FU37.1
#=GS F0RNV4_DEIPM/63-242     AC F0RNV4.1
#=GS G3SRR2_LOXAF/1230-1458  AC G3SRR2.1
#=GS H2AQR2_KAZAF/1218-1446  AC H2AQR2.1
#=GS H0W517_CAVPO/1-179      AC H0W517.1
#=GS F6ZAN9_MACMU/1242-1467  AC F6ZAN9.1
#=GS A6EZC4_9ALTE/55-228     AC A6EZC4.1
#=GS G1QSE7_NOMLE/793-982    AC G1QSE7.1
#=GS C7AFG8_AEDAE/4-71       AC C7AFG8.1
#=GS F2U270_SALS5/991-1174   AC F2U270.1
#=GS H5VP35_SALSE/64-237     AC H5VP35.1
#=GS Q6VVE1_HIRME/1-115      AC Q6VVE1.1
#=GS D3ZPR1_RAT/1227-1443    AC D3ZPR1.1
#=GS H2PB50_PONAB/155-396    AC H2PB50.1
#=GS E2B5I1_HARSA/20-260     AC E2B5I1.1
#=GS Q23FG9_TETTS/554-775    AC Q23FG9.1
#=GS D3JJF8_9ACAR/1255-1480  AC D3JJF8.1
#=GS A0DBZ5_PARTE/253-472    AC A0DBZ5.1
#=GS G3UWT1_MOUSE/380-611    AC G3UWT1.1
#=GS D8TZM7_VOLCA/23-206     AC D8TZM7.1
#=GS B4MJW8_DROWI/526-726    AC B4MJW8.1
#=GS F6R123_HORSE/1160-1370  AC F6R123.1
#=GS H2R650_PANTR/4771-4936  AC H2R650.1
#=GS A0DW33_PARTE/116-221    AC A0DW33.1
#=GS F7FZ81_ORNAN/434-642    AC F7FZ81.1
#=GS Q06IP1_PANIN/132-357    AC Q06IP1.1
#=GS F7C7D4_MACMU/73-322     AC F7C7D4.1
#=GS Q17F36_AEDAE/1693-2022  AC Q17F36.1
#=GS Q4D7M2_TRYCC/731-905    AC Q4D7M2.1
#=GS E7F3Z3_DANRE/256-472    AC E7F3Z3.1
#=GS Q4S7F3_TETNG/2292-2588  AC Q4S7F3.1
#=GS E1ZNN9_CHLVA/40-84      AC E1ZNN9.1
#=GS B6SV43_MAIZE/96-299     AC B6SV43.1
#=GS G1QMD6_NOMLE/873-1069   AC G1QMD6.1
#=GS F7D825_ORNAN/1-204      AC F7D825.1
#=GS F1QH36_DANRE/524-718    AC F1QH36.1
#=GS G3SJ57_GORGO/793-982    AC G3SJ57.1
#=GS F0YN98_AURAN/141-286    AC F0YN98.1
#=GS H2T7X3_TAKRU/144-328    AC H2T7X3.1
#=GS B9RVZ4_RICCO/132-315    AC B9RVZ4.1
#=GS B7Q558_IXOSC/432-661    AC B7Q558.1
#=GS E4T988_RIEAD/71-242     AC E4T988.1
#=GS Q59GD8_HUMAN/250-444    AC Q59GD8.1
#=GS G1LEP3_AILME/156-413    AC G1LEP3.1
#=GS H0ZTW1_TAEGU/229-403    AC H0ZTW1.1
#=GS E5S6A6_TRISP/304-391    AC E5S6A6.1
#=GS Q06AY5_CAEEL/905-1140   AC Q06AY5.1
#=GS E2R640_CANFA/1570-1779  AC E2R640.1
#=GS A2BHF4_DANRE/127-348    AC A2BHF4.1
#=GS Q2EZ58_DANRE/12-201     AC Q2EZ58.1
#=GS H0XGR2_OTOGA/4604-4763  AC H0XGR2.1
#=GS H9GF31_ANOCA/805-1033   AC H9GF31.1
#=GS B4I0E8_DROSE/135-222    AC B4I0E8.1
#=GS B4IL98_DROSE/475-666    AC B4IL98.1
#=GS E3RSD6_PYRTT/1258-1490  AC E3RSD6.1
#=GS D2GVK2_AILME/53-235     AC D2GVK2.1
#=GS Q2LCU3_9TELE/18-207     AC Q2LCU3.1
#=GS E0S2Q8_BUTPB/68-249     AC E0S2Q8.1
#=GS G3QFV3_GORGO/834-1064   AC G3QFV3.1
#=GS E5DMQ9_9TELE/1-177      AC E5DMQ9.1
#=GS A8JF89_CHLRE/1551-1791  AC A8JF89.1
#=GS E9H410_DAPPU/139-318    AC E9H410.1
#=GS H0ZPV0_TAEGU/250-433    AC H0ZPV0.1
#=GS I1Q064_ORYGL/109-376    AC I1Q064.1
#=GS H9IGX0_ATTCE/1-67       AC H9IGX0.1
#=GS B5YLW4_THAPS/81-304     AC B5YLW4.1
#=GS C3RTM3_AEDAE/1356-1578  AC C3RTM3.1
#=GS H0Z9V1_TAEGU/801-990    AC H0Z9V1.1
#=GS G1MHQ3_AILME/86-268     AC G1MHQ3.1
#=GS Q5RGQ4_DANRE/4602-4763  AC Q5RGQ4.1
#=GS G3WI02_SARHA/261-450    AC G3WI02.1
#=GS A7RI02_NEMVE/72-293     AC A7RI02.1
#=GS A7ULH1_ANOGA/5-63       AC A7ULH1.1
#=GS G3R9Y5_GORGO/159-446    AC G3R9Y5.1
#=GS G7N706_MACMU/787-976    AC G7N706.1
#=GS A6CCH3_9PLAN/53-222     AC A6CCH3.1
#=GS F7SJJ8_9GAMM/53-227     AC F7SJJ8.1
#=GS H2NG40_PONAB/1226-1448  AC H2NG40.1
#=GS A9RQ56_PHYPA/476-683    AC A9RQ56.1
#=GS O01307_BLAGE/1306-1528  AC O01307.1
#=GS H3BIF6_LATCH/265-504    AC H3BIF6.1
#=GS H2UT91_TAKRU/805-1034   AC H2UT91.1
#=GS B2BF56_9BILA/186-357    AC B2BF56.1
#=GS F7RP34_9GAMM/82-253     AC F7RP34.1
#=GS B9S124_RICCO/94-297     AC B9S124.1
#=GS Q4RZH4_TETNG/935-1048   AC Q4RZH4.1
#=GS I1MUD0_SOYBN/84-284     AC I1MUD0.1
#=GS Q8JG57_XENLA/401-603    AC Q8JG57.1
#=GS F7D8R6_MONDO/158-411    AC F7D8R6.1
#=GS C7AKA0_9SAUR/1416-1626  AC C7AKA0.1
#=GS E6ZFL0_DICLA/1167-1401  AC E6ZFL0.1
#=GS D5QVL2_METTR/67-247     AC D5QVL2.1
#=GS C9X5S2_SALTD/46-219     AC C9X5S2.1
#=GS D0N4K3_PHYIT/29-335     AC D0N4K3.1
#=GS A2BHF4_DANRE/1477-1679  AC A2BHF4.1
#=GS G3HQW0_CRIGR/561-756    AC G3HQW0.1
#=GS H0Z2W9_TAEGU/385-566    AC H0Z2W9.1
#=GS Q5SUG4_MOUSE/119-394    AC Q5SUG4.1
#=GS H9EA49_ELANI/1-107      AC H9EA49.1
#=GS G0N8Q8_CAEBE/296-497    AC G0N8Q8.1
#=GS E5DMQ4_9TELE/467-694    AC E5DMQ4.1
#=GS H0WCC5_CAVPO/1309-1533  AC H0WCC5.1
#=GS A0CX77_PARTE/175-378    AC A0CX77.1
#=GS B7ZRQ9_XENLA/228-402    AC B7ZRQ9.1
#=GS G7N5Q0_MACMU/214-391    AC G7N5Q0.1
#=GS A2BHF3_DANRE/1547-1636  AC A2BHF3.1
#=GS G1NAS5_MELGA/265-454    AC G1NAS5.1
#=GS A5APS7_VITVI/102-302    AC A5APS7.1
#=GS G1QH14_NOMLE/479-682    AC G1QH14.1
#=GS H2RLK5_TAKRU/959-1188   AC H2RLK5.1
#=GS F1S1Z0_PIG/117-327      AC F1S1Z0.1
#=GS Q3UHA5_MOUSE/91-314     AC Q3UHA5.1
#=GS G3UWI6_MOUSE/386-617    AC G3UWI6.1
#=GS A0PAE6_PLUXY/785-972    AC A0PAE6.2
#=GS F6VIL0_ORNAN/180-377    AC F6VIL0.1
#=GS H2PU57_PONAB/92-137     AC H2PU57.1
#=GS C5KTC6_PERM5/53-249     AC C5KTC6.1
#=GS D8TUN8_VOLCA/152-374    AC D8TUN8.1
#=GS B7Z3R2_HUMAN/74-251     AC B7Z3R2.1
#=GS F1A9A8_MACEU/422-638    AC F1A9A8.1
#=GS A3GFK3_PICST/888-1082   AC A3GFK3.2
#=GS G1LIU1_AILME/393-581    AC G1LIU1.1
#=GS F1NRL8_CHICK/229-403    AC F1NRL8.1
#=GS F1RPN2_PIG/1567-1777    AC F1RPN2.1
#=GS Q93X00_EUCCA/102-299    AC Q93X00.1
#=GS F6SRB9_XENTR/249-437    AC F6SRB9.1
#=GS B0ZPU8_DRORO/54-192     AC B0ZPU8.1
#=GS CNG_DROME/144-346       AC Q24278.2
#=GS F1MMU9_BOVIN/160-410    AC F1MMU9.2
#=GS G1SLV4_RABIT/284-472    AC G1SLV4.1
#=GS A2A3F0_HUMAN/749-957    AC A2A3F0.1
#=GS E1FV94_LOALO/7-53       AC E1FV94.1
#=GS D0P0S8_PHYIT/1011-1208  AC D0P0S8.1
#=GS F7IDA9_CALJA/1565-1775  AC F7IDA9.1
#=GS A0DR68_PARTE/913-1103   AC A0DR68.1
#=GS H2TB38_TAKRU/1224-1448  AC H2TB38.1
#=GS H0VJG5_CAVPO/177-371    AC H0VJG5.1
#=GS E1FP92_LOALO/750-940    AC E1FP92.1
#=GS B4PXT9_DROYA/180-428    AC B4PXT9.1
#=GS H2PAH5_PONAB/1212-1436  AC H2PAH5.1
#=GS B0S6W6_DANRE/918-1153   AC B0S6W6.1
#=GS F1N3B2_BOVIN/447-678    AC F1N3B2.2
#=GS G1PL56_MYOLU/791-980    AC G1PL56.1
#=GS G9K520_MUSPF/137-226    AC G9K520.1
#=GS H2UHA6_TAKRU/4743-4901  AC H2UHA6.1
#=GS B1AYL0_MOUSE/1536-1746  AC B1AYL0.1
#=GS C0JSV8_CIOIN/189-374    AC C0JSV8.1
#=GS F7CX37_MONDO/158-350    AC F7CX37.1
#=GS Q19QZ8_HUMAN/1312-1536  AC Q19QZ8.1
#=GS A0BDL8_PARTE/276-493    AC A0BDL8.1
#=GS F8WGN0_MOUSE/1094-1316  AC F8WGN0.1
#=GS A0YRS1_LYNSP/75-251     AC A0YRS1.1
#=GS H3BDR9_LATCH/1162-1390  AC H3BDR9.1
#=GS Q8CCS4_MOUSE/1-174      AC Q8CCS4.1
#=GS CAC1S_CYPCA/1168-1401   AC P22316.1
#=GS H2ZHJ4_CIOSA/1408-1611  AC H2ZHJ4.1
#=GS E6ZEZ7_DICLA/311-496    AC E6ZEZ7.1
#=GS E3LCC0_CAERE/708-899    AC E3LCC0.1
#=GS E9PT56_RAT/1283-1505    AC E9PT56.1
#=GS F6U4U5_XENTR/229-338    AC F6U4U5.1
#=GS E5DMS2_9TELE/431-659    AC E5DMS2.1
#=GS H2YUA2_CIOSA/80-278     AC H2YUA2.1
#=GS G5BKK9_HETGA/1200-1430  AC G5BKK9.1
#=GS F6PHJ1_HORSE/919-1154   AC F6PHJ1.1
#=GS A7SLD1_NEMVE/362-532    AC A7SLD1.1
#=GS E2C8H5_HARSA/320-542    AC E2C8H5.1
#=GS E9QFG9_DANRE/7-220      AC E9QFG9.1
#=GS Q6B4S2_HUMAN/10-260     AC Q6B4S2.1
#=GS H2N0I3_ORYLA/229-409    AC H2N0I3.1
#=GS H2TB42_TAKRU/1119-1331  AC H2TB42.1
#=GS Q22N13_TETTS/136-376    AC Q22N13.1
#=GS F1NK95_CHICK/224-405    AC F1NK95.1
#=GS D0NPC2_PHYIT/207-404    AC D0NPC2.1
#=GS TRPG_CAEEL/1341-1555    AC Q93971.4
#=GS F7DGC2_MACMU/2312-2539  AC F7DGC2.1
#=GS H2RZB4_TAKRU/1354-1564  AC H2RZB4.1
#=GS F7FW40_ORNAN/895-1178   AC F7FW40.1
#=GS G3VY70_SARHA/224-409    AC G3VY70.1
#=GS G5EFJ9_CAEEL/162-375    AC G5EFJ9.1
#=GS G1R8N6_NOMLE/1308-1531  AC G1R8N6.1
#=GS Q9WUB8_RAT/1647-1852    AC Q9WUB8.1
#=GS CNG17_ARATH/127-398     AC Q8L7Z0.1
#=GS G1MQJ3_MELGA/1153-1381  AC G1MQJ3.1
#=GS H2RZV0_TAKRU/1360-1573  AC H2RZV0.1
#=GS A8WRW6_CAEBR/1096-1303  AC A8WRW6.1
#=GS HCN1_MOUSE/166-382      AC O88704.1
#=GS F7D483_ORNAN/88-272     AC F7D483.1
#=GS E2QSU0_CANFA/1611-1816  AC E2QSU0.1
#=GS H0VP74_CAVPO/269-453    AC H0VP74.1
#=GS E9DB72_COCPS/415-746    AC E9DB72.1
#=GS G3R3Q0_GORGO/646-833    AC G3R3Q0.1
#=GS I1RCP1_GIBZE/1544-1750  AC I1RCP1.1
#=GS Q9PDF3_XYLFA/69-239     AC Q9PDF3.1
#=GS F1QB86_DANRE/766-956    AC F1QB86.1
#=GS F1NJQ0_CHICK/1-231      AC F1NJQ0.1
#=GS F6YFJ5_HORSE/1114-1167  AC F6YFJ5.1
#=GS H2ZAK3_CIOSA/29-219     AC H2ZAK3.1
#=GS D3Z1H7_MOUSE/455-658    AC D3Z1H7.1
#=GS F7FR86_MONDO/1265-1490  AC F7FR86.1
#=GS F7EQN0_CALJA/72-185     AC F7EQN0.1
#=GS E3X6M0_ANODA/2-80       AC E3X6M0.1
#=GS SCNA_DROME/1653-1859    AC P35500.3
#=GS SCNBA_HUMAN/1092-1307   AC Q9UI33.2
#=GS G1QSE7_NOMLE/1244-1472  AC G1QSE7.1
#=GS F1NBQ3_CHICK/208-396    AC F1NBQ3.1
#=GS Q4SMF4_TETNG/740-804    AC Q4SMF4.1
#=GS F7BQ57_HORSE/885-1094   AC F7BQ57.1
#=GS TPC2_MOUSE/455-676      AC Q8BWC0.1
#=GS H2ZPU6_CIOSA/1187-1406  AC H2ZPU6.1
#=GS H2T430_TAKRU/1259-1485  AC H2T430.1
#=GS C4X9W1_KLEPN/63-236     AC C4X9W1.1
#=GS C7AKF3_THAAT/1-69       AC C7AKF3.1
#=GS H2TUU7_TAKRU/1521-1731  AC H2TUU7.1
#=GS B3MXV7_DROAN/269-465    AC B3MXV7.1
#=GS F1LPJ2_RAT/4575-4738    AC F1LPJ2.1
#=GS H0W015_CAVPO/1-90       AC H0W015.1
#=GS H3DA99_TETNG/626-815    AC H3DA99.1
#=GS D3ZRQ6_RAT/138-361      AC D3ZRQ6.1
#=GS E6ZGJ0_DICLA/715-901    AC E6ZGJ0.1
#=GS F7IHB1_CALJA/2276-2532  AC F7IHB1.1
#=GS Q5RHB2_DANRE/505-697    AC Q5RHB2.1
#=GS H2SNA7_TAKRU/161-418    AC H2SNA7.1
#=GS A7SIU2_NEMVE/193-368    AC A7SIU2.1
#=GS F7A622_HORSE/445-647    AC F7A622.1
#=GS E1BK43_BOVIN/73-321     AC E1BK43.2
#=GS H3A6R0_LATCH/866-1096   AC H3A6R0.1
#=GS B3MKM4_DROAN/704-944    AC B3MKM4.1
#=GS H9JUY3_BOMMO/891-1106   AC H9JUY3.1
#=GS F7BUC2_MONDO/781-970    AC F7BUC2.1
#=GS G3SRR2_LOXAF/1551-1761  AC G3SRR2.1
#=GS E1FP92_LOALO/1221-1447  AC E1FP92.1
#=GS G5E8H5_MOUSE/248-349    AC G5E8H5.1
#=GS B3RKW1_TRIAD/516-709    AC B3RKW1.1
#=GS E9Q998_MOUSE/466-660    AC E9Q998.1
#=GS E9INK6_SOLIN/1487-1693  AC E9INK6.1
#=GS H2V2J5_TAKRU/4810-4984  AC H2V2J5.1
#=GS H0XMK4_OTOGA/224-405    AC H0XMK4.1
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