GenomeNet

Database: Pfam
Entry: IpaD
LinkDB: IpaD
Original site: IpaD 
#=GF ID   IpaD
#=GF AC   PF06511.9
#=GF DE   Invasion plasmid antigen IpaD
#=GF AU   Moxon SJ
#=GF SE   Pfam-B_16150 (release 10.0)
#=GF GA   25.00 25.00;
#=GF TC   31.70 26.50;
#=GF NC   20.90 21.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10971588
#=GF RT   Characterization of the interaction of IpaB and IpaD, proteins
#=GF RT   required for entry of Shigella flexneri into epithelial cells,
#=GF RT   with a lipid membrane. 
#=GF RA   De Geyter C, Wattiez R, Sansonetti P, Falmagne P, Ruysschaert
#=GF RA   JM, Parsot C, Cabiaux V; 
#=GF RL   Eur J Biochem 2000;267:5769-5776.
#=GF DR   INTERPRO; IPR009483;
#=GF CC   This family consists of several invasion plasmid antigen IpaD
#=GF CC   proteins. Entry of Shigella flexneri into epithelial cells and
#=GF CC   lysis of the phagosome involve the IpaB, IpaC, and IpaD
#=GF CC   proteins, which are secreted by type III secretion machinery.
#=GF SQ   30
#=GS V5UEP0_9BURK/1-204        AC V5UEP0.1
#=GS K8WT07_PRORE/106-358      AC K8WT07.1
#=GS Q7NUT0_CHRVO/40-397       AC Q7NUT0.1
#=GS Q7NUT0_CHRVO/40-397       DR PDB; 2P7N A; 47-392;
#=GS BIPD_BURPS/127-308        AC Q63K37.1
#=GS BIPD_BURPS/127-308        DR PDB; 3NFT A; 1127-1304;
#=GS BIPD_BURPS/127-308        DR PDB; 2IZP B; 2127-2305;
#=GS BIPD_BURPS/127-308        DR PDB; 2J9T A; 127-301;
#=GS BIPD_BURPS/127-308        DR PDB; 2IXR A; 127-302;
#=GS BIPD_BURPS/127-308        DR PDB; 2J9T B; 127-301;
#=GS BIPD_BURPS/127-308        DR PDB; 2IZP A; 1127-1301;
#=GS B2VG37_ERWT9/104-282      AC B2VG37.1
#=GS G2H1Q8_9ENTR/3-163        AC G2H1Q8.1
#=GS D2UAI5_XANAP/423-624      AC D2UAI5.1
#=GS Q2NX44_SODGM/91-385       AC Q2NX44.1
#=GS W0I4E9_9ENTR/58-252       AC W0I4E9.1
#=GS B2VEG5_ERWT9/292-362      AC B2VEG5.1
#=GS Q2NRA1_SODGM/79-264       AC Q2NRA1.1
#=GS Q326T1_SHIDS/1-330        AC Q326T1.1
#=GS W0HTC9_9ENTR/65-400       AC W0HTC9.1
#=GS W8U1G3_YEREN/16-260       AC W8U1G3.1
#=GS W0I4E9_9ENTR/264-351      AC W0I4E9.1
#=GS W0HRN3_9ENTR/107-385      AC W0HRN3.1
#=GS W8U1G3_YEREN/300-366      AC W8U1G3.1
#=GS SIPD_SALTY/5-341          AC Q56026.1
#=GS SIPD_SALTY/5-341          DR PDB; 2YM9 A; 32-339;
#=GS SIPD_SALTY/5-341          DR PDB; 3ZQB B; 141-340;
#=GS SIPD_SALTY/5-341          DR PDB; 3O01 A; 39-341;
#=GS SIPD_SALTY/5-341          DR PDB; 2YM0 A; 132-329;
#=GS SIPD_SALTY/5-341          DR PDB; 3ZQE B; 146-341;
#=GS SIPD_SALTY/5-341          DR PDB; 2YM9 D; 127-341;
#=GS SIPD_SALTY/5-341          DR PDB; 3NZZ B; 47-336;
#=GS SIPD_SALTY/5-341          DR PDB; 3O02 B; 47-336;
#=GS SIPD_SALTY/5-341          DR PDB; 3ZQE A; 129-336;
#=GS SIPD_SALTY/5-341          DR PDB; 2YM9 C; 128-341;
#=GS SIPD_SALTY/5-341          DR PDB; 3NZZ A; 39-341;
#=GS SIPD_SALTY/5-341          DR PDB; 3O00 A; 39-341;
#=GS SIPD_SALTY/5-341          DR PDB; 3O02 A; 39-341;
#=GS SIPD_SALTY/5-341          DR PDB; 3ZQB A; 129-336;
#=GS SIPD_SALTY/5-341          DR PDB; 2YM0 B; 132-330;
#=GS SIPD_SALTY/5-341          DR PDB; 2YM9 B; 35-337;
#=GS SIPD_SALTY/5-341          DR PDB; 3O01 B; 42-338;
#=GS SIPD_SALTY/5-341          DR PDB; 3O00 B; 47-334;
#=GS G8Q411_PSEFL/33-328       AC G8Q411.1
#=GS A9MF91_SALAR/5-338        AC A9MF91.1
#=GS B4EYC6_PROMH/97-346       AC B4EYC6.1
#=GS A0A0F5JTX1_9BURK/372-597  AC A0A0F5JTX1.1
#=GS B2VEG5_ERWT9/88-246       AC B2VEG5.1
#=GS I6HJ42_SHIFL/637-740      AC I6HJ42.1
#=GS B2VG37_ERWT9/295-382      AC B2VG37.1
#=GS D4C1Y6_PRORE/109-353      AC D4C1Y6.1
#=GS A0A0K1QPM9_PSEFL/46-360   AC A0A0K1QPM9.1
#=GS C0AR40_9ENTR/32-128       AC C0AR40.1
#=GS A0A0M9GH54_9PSED/122-322  AC A0A0M9GH54.1
#=GS A0A068Z6F4_9ENTR/71-321   AC A0A068Z6F4.1
V5UEP0_9BURK/1-204                   .............................................................................................m----------------------------------------------------------------------------.....-------------------...---------..---.--------.-------.....---.--.-.---.----.....--.------.--------ADLIGDIKD..GYLDVYSEAVAKYLAFNKAL.S.D.LISK.LSGWISTSS.DGKEVTLNIGELRKALNDILAEF.........KPPNKNSVLY..P.KQDkdS..ND.IEGGTK.EDAE.KW..A....RDFGLPES............-SVQEQPEGSGKWVVV......I......DTSPIDR.......MLDSIPKDGD.........EKK--MNPFELDIWRSGFTSQENQVKTMMQQLMQRYTTANSTYDNLVKVLSSTIASTLEVAKGFL..................................
K8WT07_PRORE/106-358                 .......................................................................lpngaaayssrsrsiedgrshig----------------------------------------------------------------------------.....-------------------...---------..---.--------.-------.....---.--.-.---.----.....--.------.------QVEKIIKNINS..GYQKDFGNIIKSSTKYMQDV.N.T.ALGK.ISEYIKAGD.DG-KIKFQRVKLLDRLDELFNKYtdhk.evklNELKKDKPLT..TdADD..DnrNY.YKNWSE.SDSSaEK..I....YEMDYSDSafdfwkkkldgqGFRVGIRGEYGQRVIR......Iy....pDITPLKE.......IMTAIYDIEDttn...gwkTAGVELMAQTVQSLQTAIDAQKNAVNSSVSRLLETFRQDNSHFDTLTQLLI--------------kliqeln...........................
Q7NUT0_CHRVO/40-397                  .............................................................................................a-PQGSAA-PALAAARAKADELGQAAREVRASVE--------------RQTAYETRLAAQRSAAAFSGGEPPQARRE.....APGAELDEARNAQTVSARL...FEGNLKGVA..QSG.HAMSAEQK.QALQSGLddvfaDAP.PQ.A.RSA.GAPMlysanAA.AGQGMA.DSDLWDMISDQIGKIKD..NYLGVYENVVGQYTDFYKAF.S.D.ILSQ.MANWIKPGG.DGNKVKLNVDALKAALEKLKKDFsl.....gdNLDNKKAVLF..P.AQS.kD..GG.IQGGSE.SDAR.KW..A....KEMGLPDAp.........ppGFSCVQKAADGNWVVV......V......DMTPIDT.......MIRDVGALGS.........GTELELDNAKFQAWQSGFKAQEENLKNTLQTLTQKYSNANSLFDNLVKVLSSTISSCLETAKSFL..................................
#=GR Q7NUT0_CHRVO/40-397       SS    .............................................................................................X-XXXXXX--THHHHHHHHHHHHHHHHHHHHHHH--------------HHHHHHHHHHHHHHHHHHSS-S-------.....-S--TTTTHHHHHHHHHHH...HHHHHHHHH..HS-.----HHHH.HHHHHHHHHHHSS--.HH.H.HTT.SHHHHHHHHHH.HHT---.HHHHHHHHHHHHHHHHH..HTHHHHHHHHHHHHHHHHHH.H.H.HHHH.HGGG-----.--------HHHHHHHHHHHHHHTS-.....-TTS--STTEEE..S.---.SS..S-.---B-H.HHHH.HH..H....HHTT-----.........TTS--SEEE-TTSSEEEE......-......--HHHHH.......HHHHHHHT--.........-------TTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--XXXXX..................................
BIPD_BURPS/127-308                   ..............................................................................dpilqglvdvigqgks----------------------------------------------------------------------------.....-------------------...---------..---.--------.-------.....---.--.-.---.----.....--.------.-----------------..-DIDAYATIVEGLTKYFQSV.A.D.VMSK.LQDYISAK-.DDKNMKIDGGKIKALIQQVIDHL.........----------..P.TM-..-..--.-QLPKG.ADIA.RW..R....KELG--DA............-----VSISDSG-VVT......I......N--P-DK.......LIKMRDSLPP.........DGTV-WDTARYQAWNTAFSGQKDNIQNDVQTLVEKYSHQNSNFDNLVKVLSGAISTLTDTAKSYL..................................
#=GR BIPD_BURPS/127-308        SS    ..............................................................................-HHHHHHHHHHHHHHH----------------------------------------------------------------------------.....-------------------...---------..---.--------.-------.....---.--.-.---.----.....--.------.-----------------..-HHHHHHHHHHHHHHHHHHH.H.H.HHHH.GGGGEEEC-.SSSEEEE-HHHHHHHHHHHHHT-.........----------..-.EE-..-..--.-E--TT.--HH.HH..H....HHH---TT............-----EEE-TTS-EEE......E......---T-HH.......HHHHHTT---.........TTEE-EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHTXXXXX..................................
B2VG37_ERWT9/104-282                 .....................slqslkssyeenetifgetasqsiakqkllvekggdaignihwevsknilntksahgslavkltrqekdsdnn----------------------------------------------------------------------------.....-------------------...---------..---.--------.-------.....---.--.-.---.--TR.....EE.ITTGTS.YAELWARISIMIGNIKS..DYVDFYAELMKKYTDMYEAF.N.S.TVQKaSSDAVTSGE.DGNSVTFDRPTMKKGYKEFS---.........----------..-.---..-..--.------.----.--..-....--------............----------------......-......-------.......----------.........-----------------------------------------------------------------aeiekidlgtvknwdkmsqeekn...........
G2H1Q8_9ENTR/3-163                   .................................................................................ksiaevkksaanm----------------------------------------------------------------------------.....-------------------...---------..---.--------.-------.....---.--.-.---.----.....--.----NA.GVDMYDRIVNIIKSMSD..NSMKPTGDAAMKYTKFNTAV.S.N.FIAD.MNKLTK--N.EGSNVVMDRFKVEQQLRQLMKDY.........SADQEAGILY..T.VDT..-..AK.QSEDNE.AIAK.KK..A....EDLGLDPA............---KVVKQKGNKWLVT......L......DTSPLDK.......MLEL------.........-----------------------------------------------------------------lpeysdknnke.......................
D2UAI5_XANAP/423-624                 .............................................................................slirsdaavygglqtvt----------------------------------------------------------------------------.....-------------------...---------..---.--------.-------.....---.--.-.---.----.....--.------.------------SNAKA..GIIDPYGSLLQEYMQYVQSI.T.D.LLSN.LSKYVTASG.DGTTVNFKADDLKSVINDMLKEG.........APFKEWSLTL..P.---..-..--.--GTSS.LSAS.DW..K....QELS----............GNFNVTQNADGTTSIS......L......DLSNLEA.......MRDSLSNY-S.........NGDIS--VTQYNAWYAGFTGQKDNVMNLSQSIAEKFSRMNSEFDNLVQLMSSAISALLESEEKYL..................................
Q2NX44_SODGM/91-385                  .................................................................srvqdilkkiellspsltridssepdsie----------------------------------------------------------------------------.....----SLKRRQKESAKAASE...LSEALQGEI..RKE.SFIRQKNY.NTLNHII....eEVK.QE.PnLEE.AYNI....yLK.DETQLT.YSEFWASIAATIASIKT..NYVDFYSSLMLQYADFYQAY.T.E.LQSK.AAGAVSEGK.DGNYIKWDNDVMDSAFKEFENKI.........ASLNNNLGTV..P.QWD..-..--.--QLSD.TEHQ.QM..A....DTLK-PAF............----AVDMETGK--IT......F......DQSALSA.......CPKSPSGGSG.........SGKSDVDMASYNAWLAAFNSMGNTFQSNMQSFAQRYTQANSTFDNLNKVLSSSITALLECAKAFL..................................
W0I4E9_9ENTR/58-252                  nnniinyakgalskvfdtrhklerklpfnnelreqstshsniakteeyidttqlalrndrlrrnsemakiekniedivnvsvlrhayesndegk----------------------------------------------------------------------------.....-------------------...---------..---.--------.-------.....---.--.-.---.----.....--.--RSES.YGKFWDKIAEDIASIKK..EYVEFYATLISKYADFYQVF.V.K.LQGE.IAGVVSEGK.DGNHIKFDNER------------.........----------..-.---..-..--.------.----.--..-....--------............----------------......-......-------.......----------.........-----------------------------------------------------------------kmeafkhfreardaiklpkiedwseenltdeqkq
B2VEG5_ERWT9/292-362                 .................................................................................kgefpngkngqvp----------------------------------------------------------------------------.....-------------------...---------..---.--------.-------.....---.--.-.---.----.....--.------.-----------------..--------------------.-.-.----.---------.-----------------------.........----------..-.---..-..--.------.----.--..-....--------............----------------......-......-------.......----------.........-------VATYNSWLVRFNAVGSALQSNMQSFSSRYSQASSTYDTLNKVFSETINRMGNNALDF-l.................................
Q2NRA1_SODGM/79-264                  ........................................................................mevllqkldgrrlaecpaiaad----------------------------------------------------------------------------.....--GSNLKEVKTALTASAQAtyeVVDQVKGLV..RKE.R-LNREVKlTQLQRNIdq.vaAKP.EL.R.QFS.CEGI.....QD.EKQWSR.YSEFWEGIACDIKSIKNkkEYVDFYSELTLKYTYFYQKF.I.E.LQAT.VAKLVKEGE.DGNHVKWDAKNFQEKFNEFKD-Y.........----------..-.---..-..--.------.----.--..-....--------............----------------......-......-------.......----------.........-----------------------------------------------------------------akvtvvydmpesaelk..................
Q326T1_SHIDS/1-330                   ..............................................................................................MNITTLTNSISTSSFSPNNTNGSSTETVNSDIKTTTSSHPVSSLTMLNDTLHNIRTTNQALKKDLSQKTLTKTSLEeialhSSQISMDVNKSAQL-----...----LDILS..KKE.YPINKDAR.ELLH---.....SAP.EE.A.ELD.GYQM.....--.----IS.HRELWDKIAKSINNINE..QYLKVYEHAVSSYTQMYQDF.S.A.VLSS.LAGWISPGGnDGNSVKLQVNSLKAELTKLKEKY.........----EDKPLY..P.ANN..-..--.--TVSK.EQAD.KW..L....TELG----............GTIGTVSRKNGGYVVN......I......NMSPIDN.......MLKSLNNLGG.........NGEVVLDNAKYQAWNAGFSAEDETMKNNLQTLVQKYSNANSIFDNLVKVLSSTISSCTDTDKLFL..................................
W0HTC9_9ENTR/65-400                  .........................................................................agtpahsvssavsamdallqk----------------------------------------------------------------LDGRRLAECPAV....aADGSNLEEVKTALTESAQAtyeVVDQVKDLL..RKE.SLTRAAKL.TQLQRNId..qvAAK.PE.L.RQS.SCEA.....TQdEKRSSR.YREFWNAIACDIKSIKK..EYVDFYSTLTLKYADFYQKY.I.E.LQAA.AAKAVKEGD.DGNHVKWDAKDFQKKFKAFK-DY.........-VAETEVCDI..P.ESS.eW..KK.INGIVDdKERE.KA..IndleKSLGLKPA............-FELERIKDESGKVIR......ItgkikfNRTAIDScpnqpsgIVESIIPDWT.........NNGQSTDMASYNAWLAAFNSMGNTFQSNMQTASQRYSQANSTFDNLNKVLSSSITALLECAKSFL..................................
W8U1G3_YEREN/16-260                  ......padtsatqsapiaethagssselnikllkeliaqmeapnradkldgiratlnqygldtsaedfnnsklrtalehlkttndraqpsddv----------------------------------------------------------------------------.....---AEMLANQ------KQQ...VKNTALALAdiQRE.VATNRTKA.NYSVSQF.....MADkEK.A.VQD.ADPEdsnkrDE.ISIHTS.YAELWAKMALAIKNIKG..DYVDFYADLMQKYTEMYKAY.NtH.VQGA.AAKAVSAGD.DGNNVKFDTTKMDGGYTDFKTE-.........----------..-.---..-..--.------.----.--..-....--------............----------------......-......-------.......----------.........-----------------------------------------------------------------vdnialslgsvknwdq..................
W0I4E9_9ENTR/264-351                 .........................................................................dkygqvkiddtayqnlpnepe----------------------------------------------------------------------------.....-------------------...---------..---.--------.-------.....---.--.-.---.----.....--.------.-----------------..--------------------.-.-.----.---------.-----------------------.........----------..-.---..-..--.------.----.--..-....--------............----------------......-......-------.......--------GR.........DEENNVNMASYNAWMAAFNSMGNIFQNNMQSTSQRYTQANSTFDNLNKVLSSTITALLECAKSFL..................................
W0HRN3_9ENTR/107-385                 ................................................................................pttidssepdcves----------------------------------------------------------------------------.....-----LKRKQKESAKAASE...LSDNLTGEI..RKE.TLIRQSNF.NTLNRMI....eEVK.QEpN.LEE.AYNI....yLK.DETELT.YSEFWASIAATIASIKT..NYVDFYSSLMLQYADFYQAY.T.E.LQSK.AAGAVSEGK.DGNYIKWDESVMSEAFQDFKDKI.........NSLNDNLGTV..P.QWD..-..--.--QLSE.TERQ.QM..A....DTLK-PAF............----AVDMSTGK--IS......F......NQDALNA.......CPTSPSGASG.........SGKSDVDMASYNAWLAAFNSMGNTFQSNMQSFSQRYTQANSTFDNLNKVLSSSITALLECAKAFL..................................
W8U1G3_YEREN/300-366                 .......................................................................................sgmdgnk----------------------------------------------------------------------------.....-------------------...---------..---.--------.-------.....---.--.-.---.----.....--.------.-----------------..--------------------.-.-.----.---------.-----------------------.........----------..-.---..-..--.------.----.--..-....--------............----------------......-......-------.......----------.........-----VSTASYQAWLASFNGGGSALQGNMQSFAQRYTQANSTFDNLNKVLSGAIASLAESAKD--vi................................
SIPD_SALTY/5-341                     ..............................................................................................QNYSASPHPGIVAERPQTP---SASEHVETAVVPSTTEHRGTDIISLSQAATKIHQAQQTLQS-------------.....TPPIS-EENNDERTLARQQ...LTSSLNALA..KSG.VSLSAEQN.ENLRSAF.....SAP.TS.A.LFS.ASPM.....AQ.PRTTIS.DAEIWDMVSQNISAIGD..SYLGVYENVVAVYTDFYQAF.S.D.ILSK.MGGWLLPGK.DGNTVKLDVTSLKNDLNSLVNKY.........NQINSNTVLF..P.AQS..G..SG.VKVATE.AEAR.QW..L....SELNLPNS............----CLKSYGSGYVVT......V......DLTPLQK.......MVQDIDGLGAp......gkDSKLEMDNAKYQAWQSGFKAQEENMKTTLQTLTQKYSNANSLYDNLVKVLSSTISSSLETAKSFL..................................
#=GR SIPD_SALTY/5-341          SS    ..............................................................................................XXXXXXXXXXXXXXXXXXX---XXXXXXXXXXSXXSXSSHHHHHHHHHHHHHHHHHHHHHHHH-------------.....S-STS-HHHHHHHHHHHHH...HHHHHHHHH..CTT.----HHHH.HHHHHHT.....SS-.SS.T.TT-.----.....--.------.HHHHHHHHHHHHHHHHH..HTHHHHHHHHHHHHHHHHHH.H.H.HHTT.GGGGEEE-S.STTEEEE-HHHHHHHHHHHHHHH.........TS-STTTEEE..S.---..S..SS.---B-H.HHHH.HH..H....HHHT--GG............----GEEEETTEEEEE......S......--HHHHH.......HHHHHHHT---......STTSSEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC..................................
G8Q411_PSEFL/33-328                  ............................................akelitegaekvnladfveqthakrirsemwalqfrqccavmthsqsagl----------------------------------------------------------------------------.....-------------------...-------LD..KSQlQQLNDEQS.KSLH-AL.....RAH.LE.E.KEPlEISE.....AL.DATINS.SNDFFEKLLELIDLIKN..GYLAGYEHVISAYSDFFADF.N.AqITGM.MKEWIEGVN.DGKEVKLNAGALFAALTDLIAKY.........THPNPDSVLF..P.KPG..D..DG.---VCR.DEAE.NW..R....IALGLPPQ............---CLKENADGTWCVV......I......DTGPLHR.......MK---DGLPP.........SGTVTWDTAKFNAWQSGINAQEERMKNMLQSFTQKYSNANSYHDNFNKTLSAHLN----------qfadmlraml........................
A9MF91_SALAR/5-338                   ..............................................................................................QNYSASPRPGLVAERPQTT---SASEHVEITAAPATTEHRGADIITLSQAATKAQQAQQTLRS-------------.....TLPVS-EENNDERTLARQQ...LTSSLHALT..KSG.VSLSAEQN.EGLRSAF.....SAP.AV.A.LFS.TAPM.....AQ.PRVTIS.DAEIWDMVSQNISAIGD..NYLGVYENVVAVYTDFYQAF.S.D.ILSK.MGTWLAPGK.DGNTVKLNVDALKSEIRSLVNKY.........NQVTKNTILF..P.SQT..G..SG.VTTATK.AEAE.QW..I....KELNLPGS............----CLKASGSGYVVL......V......DTGPLNK.......MVSDLNGIGS.........GSALELDNAKYQAWQAGFKAQEENLKTTLQTLTQKYSNANSLYDNLVKVLSSTISSSLETAKSFL..................................
B4EYC6_PROMH/97-346                  ....................................................................................lrkkdnsyet----------------------------------------------------------------------------.....-------------------...---------..---.--------.-------.....---.--.-.---.----.....--.----DS.LSDLFNNVKQSIVSGKA..DYLDVLKDIFSNYMNFVNEL.R.Q.TISN.LNKYQKAGS.KEGTVNFDFKSFFNDLSNIRDKYknptgtvddPFVFKSRLFF..Q.HQK..D..GTyLRTIDG.QEV-.HYsdL....QQVN--NAadalekllkginGISVSIQRRGGEPDVDidcrgrI......DCTDLEK.......LLNDLSKKVS.........NTD-DINQTEFELFRKTIDALDKKINTNLDELSKKYSTANSNYDNFVKIVSSTMNTLLEMAKGFL..................................
A0A0F5JTX1_9BURK/372-597             .................................................................mknvtqytiqslvsgesavdqamarmdel----------------------------------------------------------------------------.....-------------------...---------..---.--------.-------.....---.--.-.---.----.....--.---QKS.DVAQYGGLKTSISEAKE..AIIDPYGQLVSEYMNYTQAV.T.D.VMSD.LSSYVTASD.DGSKVTFKANELRDDIQA---KL.........NTLSGWSITL..P.GTA..-..--.--VLSS.---S.DW..S....SELK----............GNFKATSNPDGTTTLT......L......DLTNLQG.......MHDSLANY-S.........DGDIS--VTQYNAWYSGFSSQKDNVQNLSQSIAEKFSKMNTTFDDLVRVMSSTITALLEAEQ---ksl...............................
B2VEG5_ERWT9/88-246                  ....................lakklgdlsaelysqdapcsvarqkeladdilsilsglnserrnvsvktefshhqskrsledlkelqavshegr----------------------------------------------------------------------------.....-------------------...---------..---.--------.-------.....---.--.-.---.----.....--.ITIGTS.YADLWAKISLAICRIKS..EYIDFYAGLMKKYLDMYQSY.NkD.VQKA.SSESLSAGE.DGNSVNFDKKIM-----------.........----------..-.---..-..--.------.----.--..-....--------............----------------......-......-------.......----------.........-----------------------------------------------------------------sdgynkfniflstt....................
I6HJ42_SHIFL/637-740                 ...............................................................vtesvivmdkaydmngtggdkaniyvspast----------------------------------------------------------------------------.....-------------------...---------..---.--------.-------.....---.--.-.---.----.....--.------.-----------------..--------------------.-.-.----.---------.-----------------------.........----------..-.---..-..--.------.----.--..-....--------............----------------......-......-------.......--WDFEGQGA.........NDSVTISSGIFNEWENSMNTMSSTVESQSQVMSEKLSQANTIFNNLTKVLSSTIEALQETQKEFL..................................
B2VG37_ERWT9/295-382                 ........................................................................ntkgkiefnlepymssvnntyp----------------------------------------------------------------------------.....-------------------...---------..---.--------.-------.....---.--.-.---.----.....--.------.-----------------..--------------------.-.-.----.---------.-----------------------.........----------..-.---..-..--.------.----.--..-....--------............----------------......-......-------.......---------G.........TSSGNISTASYQAWLATFNSAGSSLQSNMQAFSQRYTQANSTFDQLNKMLSGVINSLGDSAKDV-l.................................
D4C1Y6_PRORE/109-353                 ..........................................................................gaathffrsqpiddgrshig----------------------------------------------------------------------------.....-------------------...---------..---.--------.-------.....---.--.-.---.----.....--.------.------EISKIIENINS..GYQKDFGNIIKSATKYMQDV.N.T.ALGK.ISEYIKAGD.SG-KIKFQRVKLLNRLDDLFEPYt......dhKKVRGNKPLTteP.DDD.nR..DY.YKDWSK.PEDS.AW.dL....YEMEYSDSafafwkkkldgqGFVVDTRTPNGKKVIR......Iy....pDLNPLRE.......IMKTIYDVEDtkd...gwkTAGVDLMAQTVQSLQTAIDAQKNAVNSSVSRLLETFRQDNSHFDTLTQLLI--------------kliqeln...........................
A0A0K1QPM9_PSEFL/46-360              ..........................sakvlnrnlenmlkcqpaakkmvenllaggaaqtliaefgervqtkdlrwqmwaqylpqygavmthcr----------------------------------------------------------------------------.....-------------------...---------..---.ETLPMEQR.QRLDAAQ.....ETI.LL.G.LGA.GQPLptqidEK.FSQSVSsSDDFFDKLLELIDLIKN..GYLAGYEHIIKAYSDFFADF.NkD.ITAM.MKEWIEGTN.DGKEVEINAGAIRIALQKLIEKY.........SPPNPTAVLF..P.APG..-..--.MGGATK.EEAE.KW..L....KALGLPAS............---CLHQNNDGTYSVV......M......DLSPLIT.......MRDSLPP--D.........VYEIIWDTAKFQAWQTGFNAQEERMKNMLQSFTQKYSNANSYHDNFNKTLSAHLSQYADMLKAM-l.................................
C0AR40_9ENTR/32-128                  .........................................................................................eiyfk----------------------------------------------------------------------------.....-------------------...---------..---.--------.-------.....---.--.-.---.----.....--.------.-----------------..--------------------.-.-.----.---------.-----------------------.........----------..-.---..-..--.------.----.--..-....--------............----------------......V......DLSRFDK.......LLDLVLGGSSedemnkspdNATVKLLSSEFNLLKNGMDAFEKNINSNLDELSKKYSAANSNYDNFVKIVSSTMNTLLEMAKGFL..................................
A0A0M9GH54_9PSED/122-322             .......................................................................................plpqapt----------------------------------------------------------------------------.....-------------------...---------..---.--------.-------.....---.--.-.---.----.....--.------.---FFDKLIELINLIGE..RYLNIYKDIVDKFSAFFDAFnS.Q.ITSK.LQQWMEAVN.EGKDIELDVGELKKALEALLAEL.........-----DDELF..-.---..-..--.--KGSK.EDAA.KW..C....EALGLPAS............---CLRDNGDGTWSVL......I......DRSPLTQ.......MIEDLVALKAg.......kDGKVVLDSASFQAWQTGFNAQTERLKNKLQELTQKYSSANTTYDNFIKVLSNHINQFTEMLK---am................................
A0A068Z6F4_9ENTR/71-321              ..............................................................................adahrgnrmvtpdaed----------------------------------------------------------------------------.....-------------------...---------..---.--ITNDAR.QLLR-DLkr.seDNY.RT.A.QTN.ALEA.....SS.DEEDVG.TPPHIKALEDLIEKIHT..KYQKLYAKITEKASQYMKDV.N.Q.ALGK.MSDYINAGK.DGKIIFDKEGFLKAFKDSLSKYF.........-DFNQDGSIS..P.KSI..-..-H.NFTGDD.KALT.FW..K....DKLG---S............GYI-VRRGSSGDIEIL......P......NSDAIKG.......IIDRIDGLKGes.....vkGEGIELSGQAFQAFQTAIDSQKNTVNNNVSELLERFRQDNSSFETLIQLL---------------qrmt..............................
#=GC SS_cons                         ...............................................................................HHHHHHHHHHHHHHHXXXXXXXXXTHHHHHHHHHHHHHHHHHHHHHHCXXSXSSHHHHHHHHHHHHHHHHHHHHHHHHHHSS-S-------.....SSSTTTCCHHHHHHHHHHH...HHHHHHHHH..CTT.----HHHH.HHHHHHCHHHHSSS-.CC.C.CTT.SHHHHHHHHHH.HHT---.HHHHHHHHHHHHHHHHH..HTHHHHHHHHHHHHHHHHHH.H.H.HHHH.GGGGEEECS.STTEEEE-HHHHHHHHHHHHHHCS.......TTS-STTTEEE..S.EE-.SS..SS.-E-BTH.HHHH.HH..H....HHHT--CC..........TTS--SCEEECTTSEEEE......C......--HHHHH.......HHHHHHHT---......STTTCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCC..................................
#=GC seq_cons                        ..................................................................................t....t..pt.t.........................................................................................................................................................................t....hattltt.ItpIps..tYlchYtplhtpYspahpsh.s.p.l.up.huphlpsup.DGpplphshsthptthpphhtch......................................st....t.th..h.....tht.........................tut..l.......h......s.sslpt.......hhp...s..s.........sst..hssspapuW.suhsu.tpshpsphQphsp+YopANShaDNLsKlLSuslsthh-.tc.....................................
//
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