GenomeNet

Database: Pfam
Entry: IpaD
LinkDB: IpaD
Original site: IpaD 
#=GF ID   IpaD
#=GF AC   PF06511.10
#=GF DE   Invasion plasmid antigen IpaD
#=GF AU   Moxon SJ
#=GF SE   Pfam-B_16150 (release 10.0)
#=GF GA   25.00 25.00;
#=GF TC   31.70 36.20;
#=GF NC   20.90 21.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10971588
#=GF RT   Characterization of the interaction of IpaB and IpaD, proteins
#=GF RT   required for entry of Shigella flexneri into epithelial cells,
#=GF RT   with a lipid membrane. 
#=GF RA   De Geyter C, Wattiez R, Sansonetti P, Falmagne P, Ruysschaert
#=GF RA   JM, Parsot C, Cabiaux V; 
#=GF RL   Eur J Biochem 2000;267:5769-5776.
#=GF DR   INTERPRO; IPR009483;
#=GF CC   This family consists of several invasion plasmid antigen IpaD
#=GF CC   proteins. Entry of Shigella flexneri into epithelial cells and
#=GF CC   lysis of the phagosome involve the IpaB, IpaC, and IpaD
#=GF CC   proteins, which are secreted by type III secretion machinery.
#=GF SQ   38
#=GS K8WT07_PRORE/106-358      AC K8WT07.1
#=GS A0A0X8GMF1_9BURK/10-273   AC A0A0X8GMF1.1
#=GS BIPD_BURPS/127-308        AC Q63K37.1
#=GS BIPD_BURPS/127-308        DR PDB; 3NFT A; 1127-1304;
#=GS BIPD_BURPS/127-308        DR PDB; 2IZP B; 2127-2305;
#=GS BIPD_BURPS/127-308        DR PDB; 2J9T A; 127-301;
#=GS BIPD_BURPS/127-308        DR PDB; 2IXR A; 127-302;
#=GS BIPD_BURPS/127-308        DR PDB; 2J9T B; 127-301;
#=GS BIPD_BURPS/127-308        DR PDB; 2IZP A; 1127-1301;
#=GS D2UAI5_XANAP/423-624      AC D2UAI5.1
#=GS W0I4E9_9GAMM/58-252       AC W0I4E9.1
#=GS D4HX51_ERWAC/77-264       AC D4HX51.1
#=GS Q2NRA1_SODGM/79-264       AC Q2NRA1.1
#=GS A0A0T9LM73_9GAMM/119-333  AC A0A0T9LM73.1
#=GS W0HTC9_9GAMM/65-400       AC W0HTC9.1
#=GS W8U1G3_YEREN/16-260       AC W8U1G3.1
#=GS E9CNW6_9GAMM/49-321       AC E9CNW6.1
#=GS B4EYC6_PROMH/97-346       AC B4EYC6.1
#=GS D4HX51_ERWAC/297-370      AC D4HX51.1
#=GS C0AR40_9GAMM/32-128       AC C0AR40.1
#=GS A0A0M9GH54_9PSED/122-322  AC A0A0M9GH54.1
#=GS A0A010S6L8_PSEFL/110-359  AC A0A010S6L8.1
#=GS V5UEP0_9BURK/1-204        AC V5UEP0.1
#=GS Q7NUT0_CHRVO/40-397       AC Q7NUT0.1
#=GS Q7NUT0_CHRVO/40-397       DR PDB; 2P7N A; 47-392;
#=GS A0A0T9WZ48_SALET/5-341    AC A0A0T9WZ48.1
#=GS G2H1Q8_9ENTR/3-163        AC G2H1Q8.1
#=GS Q2NX44_SODGM/91-385       AC Q2NX44.1
#=GS A0A0X8GMF1_9BURK/281-354  AC A0A0X8GMF1.1
#=GS Q326T1_SHIDS/1-330        AC Q326T1.1
#=GS A0A0F7D2K6_SERFO/290-494  AC A0A0F7D2K6.1
#=GS A0A0L7T8B8_9GAMM/3-282    AC A0A0L7T8B8.1
#=GS W0I4E9_9GAMM/264-351      AC W0I4E9.1
#=GS W0HRN3_9GAMM/107-385      AC W0HRN3.1
#=GS D4I1Q2_ERWAC/310-379      AC D4I1Q2.1
#=GS D4I1Q2_ERWAC/110-284      AC D4I1Q2.1
#=GS W8U1G3_YEREN/300-366      AC W8U1G3.1
#=GS A0A0X1T7B0_PSEAA/100-357  AC A0A0X1T7B0.1
#=GS SIPD_SALTY/5-341          AC Q56026.1
#=GS SIPD_SALTY/5-341          DR PDB; 2YM9 A; 32-339;
#=GS SIPD_SALTY/5-341          DR PDB; 3ZQB B; 141-340;
#=GS SIPD_SALTY/5-341          DR PDB; 3O01 A; 39-341;
#=GS SIPD_SALTY/5-341          DR PDB; 2YM9 D; 127-341;
#=GS SIPD_SALTY/5-341          DR PDB; 3ZQE B; 146-341;
#=GS SIPD_SALTY/5-341          DR PDB; 2YM0 A; 132-329;
#=GS SIPD_SALTY/5-341          DR PDB; 3NZZ B; 47-336;
#=GS SIPD_SALTY/5-341          DR PDB; 3O02 B; 47-336;
#=GS SIPD_SALTY/5-341          DR PDB; 3ZQE A; 129-336;
#=GS SIPD_SALTY/5-341          DR PDB; 2YM9 C; 128-341;
#=GS SIPD_SALTY/5-341          DR PDB; 3NZZ A; 39-341;
#=GS SIPD_SALTY/5-341          DR PDB; 3O02 A; 39-341;
#=GS SIPD_SALTY/5-341          DR PDB; 3ZQB A; 129-336;
#=GS SIPD_SALTY/5-341          DR PDB; 3O00 A; 39-341;
#=GS SIPD_SALTY/5-341          DR PDB; 2YM0 B; 132-330;
#=GS SIPD_SALTY/5-341          DR PDB; 2YM9 B; 35-337;
#=GS SIPD_SALTY/5-341          DR PDB; 3O01 B; 42-338;
#=GS SIPD_SALTY/5-341          DR PDB; 3O00 B; 47-334;
#=GS A9MF91_SALAR/5-338        AC A9MF91.1
#=GS G5LSS3_SALET/1-39         AC G5LSS3.1
#=GS I0QL29_9GAMM/40-311       AC I0QL29.1
#=GS A0A0F5JTX1_9BURK/372-597  AC A0A0F5JTX1.1
#=GS A0A0T9KA61_9GAMM/6-405    AC A0A0T9KA61.1
#=GS A0A0R0DEB9_9GAMM/12-245   AC A0A0R0DEB9.1
K8WT07_PRORE/106-358                 ...........................................................................................................lpngaaayssrsrsiedgrshig----------------------------------------------------------------------------.....-------------------...---------..-..-----...-----.-------.....---.--.-.-------.....--.------------QVEKIIKNINS..GYQKDFGNIIKSSTKYMQDV.N.TALGKI.SEYI.KAGD.DG-KIKFQRVKLLDRLDELFNKYtdhk.evklNELKKDKPLTT.dADD..DnrNY.YK.....NWSE.SDSSaEK..I....YEMDYSDSafdfwkkkldgqGFRV..GIRGEYGQ..RVIR......Iy....pDITPLKE.......IMTAI.YDIEDttn...gwkTA.GVELMAQTVQSLQTAIDAQKNAVNSSV....SRLLETFRQDNSHFDTLTQLLI--------------kliqeln...........................
A0A0X8GMF1_9BURK/10-273              ..................................................................................asslssqqthiekpvfdtplaqlgavekwdasvarvqqalhnivvrpe----------------------------------------------------------------------------.....----GLKVALEEQASAEQV...LQSKVREVS..S..QLPLE...SAHLR.DNLPPEF.....LAL.QH.Q.VGGGLNT.....ES.TLKFMSDREILAIVSGSMVDIKE..NYQKIFASATSKYADFFKDF.S.ATITKL.AGYF.KADG.-TNDMKVDVDSLQNDLLAVMSKH.........----KNVALVS..---..-..--.--.....CDTE.QEAK.YW..A....KELGLAADad........isGSSCpaYIKMKDGK..WCVY......P......NLEPLVQ.......ILVAS.NYNNA.........GD.KVKLD----------------------....------------------------------------lspryg............................
BIPD_BURPS/127-308                   ..................................................................................................................dpilqglvdvigqgks----------------------------------------------------------------------------.....-------------------...---------..-..-----...-----.-------.....---.--.-.-------.....--.-----------------------..-DIDAYATIVEGLTKYFQSV.A.DVMSKL.QDYI.SAK-.DDKNMKIDGGKIKALIQQVIDHL.........----------P..TM-..-..--.-Q.....LPKG.ADIA.RW..R....KELG--DA............----..-VSISDSG..-VVT......I......N--P-DK.......LIKMR.DSLPP.........DG.TV-WDTARYQAWNTAFSGQKDNIQNDV....QTLVEKYSHQNSNFDNLVKVLSGAISTLTDTAKSYL..................................
#=GR BIPD_BURPS/127-308        SS    ..................................................................................................................-HHHHHHHHHHHHHHH----------------------------------------------------------------------------.....-------------------...---------..-..-----...-----.-------.....---.--.-.-------.....--.-----------------------..-HHHHHHHHHHHHHHHHHHH.H.HHHHHG.GGGE.EEC-.SSSEEEE-HHHHHHHHHHHHHT-.........-----------..EE-..-..--.-E.....--TT.--HH.HH..H....HHH---TT............----..-EEE-TTS..-EEE......E......---T-HH.......HHHHH.TT---.........TT.EE-EEHHHHHHHHHHHHHHHHHHHHHH....HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHTXXXXX..................................
D2UAI5_XANAP/423-624                 .................................................................................................................slirsdaavygglqtvt----------------------------------------------------------------------------.....-------------------...---------..-..-----...-----.-------.....---.--.-.-------.....--.------------------SNAKA..GIIDPYGSLLQEYMQYVQSI.T.DLLSNL.SKYV.TASG.DGTTVNFKADDLKSVINDMLKEG.........APFKEWSLTLP..---..-..--.--.....GTSS.LSAS.DW..K....QELS----............GNFN..VTQNADGT..TSIS......L......DLSNLEA.......MRDSL.SNY-S.........NG.DIS--VTQYNAWYAGFTGQKDNVMNLS....QSIAEKFSRMNSEFDNLVQLMSSAISALLESEEKYL..................................
W0I4E9_9GAMM/58-252                  ....................................nnniinyakgalskvfdtrhklerklpfnnelreqstshsniakteeyidttqlalrndrlrrnsemakiekniedivnvsvlrhayesndegk----------------------------------------------------------------------------.....-------------------...---------..-..-----...-----.-------.....---.--.-.-------.....--.--RSESYGKFWDKIAEDIASIKK..EYVEFYATLISKYADFYQVF.V.KLQGEI.AGVV.SEGK.DGNHIKFDNER------------.........-----------..---..-..--.--.....----.----.--..-....--------............----..--------..----......-......-------.......-----.-----.........--.---------------------------....------------------------------------kmeafkhfreardaiklpkiedwseenltdeqkq
D4HX51_ERWAC/77-264                  ..............................................................nnstfvfesskmckslqylescvnntkiflneknlipherfspsitekqrleeevdkafdyirneisn----------------------------------------------------------------------------.....-------------------...---------..-..----I...CLNTK.SSLSKTF.....ATY.AS.V.SSNREE-.....--.ISTGTSYAELWARISTAITIIQE..DYVDFYADLMKKYTDMYQSF.N.ENVQKAsSDAV.HVGS.EANTVDFNAHKMKEGYKKFEEEV.........-----------..---..-..--.--.....----.----.--..-....--------............----..--------..----......-......-------.......-----.-----.........--.---------------------------....------------------------------------esidlgsvknwde.....................
Q2NRA1_SODGM/79-264                  ............................................................................................................mevllqkldgrrlaecpaiaad----------------------------------------------------------------------------.....--GSNLKEVKTALTASAQAtyeVVDQVKGLV..R..KER-L...NREVKlTQLQRNIdq.vaAKP.EL.R.QFSCEGI.....QD.EKQWSRYSEFWEGIACDIKSIKNkkEYVDFYSELTLKYTYFYQKF.I.ELQATV.AKLV.KEGE.DGNHVKWDAKNFQEKFNEFKD-Y.........-----------..---..-..--.--.....----.----.--..-....--------............----..--------..----......-......-------.......-----.-----.........--.---------------------------....------------------------------------akvtvvydmpesaelk..................
A0A0T9LM73_9GAMM/119-333             ..................................................................................................................kslievvdigyedfqs----------------------------------------------------------------------------.....-------------------...---------..-..-----...-----.-------.....---.--.-.-------.....--.-----------------------..----KHKEIVEKYSKYYEAF.S.EGLSTQ.SKYV.GAGS.DANKIDFKKRSFAASLNDKLIIYsn.....esSFYNTETGRLN..ENA..F..SN.VKalytlTGDE.KRFN.YW..K....KELS-PEL............--NV..TWDEEKGC..IYIL......P......NLDNLKS.......IFKSL.ENSDGvir...nnhSG.NDDIATATYQAWQAGNDSIKNRQQNAL....NQLTEKYGHHLNKLENLIQFLIRAI-----------edhaksn...........................
W0HTC9_9GAMM/65-400                  .............................................................................................................agtpahsvssavsamdallqk----------------------------------------------------------------LDGRRLAECPAV....aADGSNLEEVKTALTESAQAtyeVVDQVKDLL..R..KESLT...RAAKL.TQLQRNId..qvAAK.PE.L.RQSSCEA.....TQdEKRSSRYREFWNAIACDIKSIKK..EYVDFYSTLTLKYADFYQKY.I.ELQAAA.AKAV.KEGD.DGNHVKWDAKDFQKKFKAFK-DY.........-VAETEVCDIP..ESS.eW..KK.IN.....GIVDdKERE.KA..IndleKSLGLKPA............-FEL..ERIKDESG..KVIR......ItgkikfNRTAIDScpnqpsgIVESI.IPDWT.........NN.GQSTDMASYNAWLAAFNSMGNTFQSNM....QTASQRYSQANSTFDNLNKVLSSSITALLECAKSFL..................................
W8U1G3_YEREN/16-260                  ..........................................padtsatqsapiaethagssselnikllkeliaqmeapnradkldgiratlnqygldtsaedfnnsklrtalehlkttndraqpsddv----------------------------------------------------------------------------.....---AEMLANQ------KQQ...VKNTALALAdiQ..REVAT...NRTKA.NYSVSQF.....MADkEK.A.VQDADPEdsnkrDE.ISIHTSYAELWAKMALAIKNIKG..DYVDFYADLMQKYTEMYKAY.NtHVQGAA.AKAV.SAGD.DGNNVKFDTTKMDGGYTDFKTE-.........-----------..---..-..--.--.....----.----.--..-....--------............----..--------..----......-......-------.......-----.-----.........--.---------------------------....------------------------------------vdnialslgsvknwdq..................
E9CNW6_9GAMM/49-321                  ..............................................................................................lyvqaayllqsnqhiqplsdpqadahrgnrmvtpda----------------------------------------------------------------------------.....-------------------...---------..-..--EDI...TNDAR.QLLR-DLkr.seDNY.RT.A.QTNALEA.....SS.DKEDVGTPPHIKALEDLIEKIHT..KYQKLYAKITEKASQYMKDV.N.QALGKM.SDYI.NAGK.DGKIIFDKEGFLKAFKDSLSKYF.........-DFNQDGSISP..KSI..-..-H.NF.....TGDD.KALT.FW..K....DKLG---S............GYI-..VRRGSSGD..IEIL......P......NSDAIKG.......IIDRI.DGLKGes.....vkGE.GIELSGQAFQAFQTAIDSQKNTVNNNV....SELLERFRQDNSSFETLIQLL---------------qrmt..............................
B4EYC6_PROMH/97-346                  ........................................................................................................................lrkkdnsyet----------------------------------------------------------------------------.....-------------------...---------..-..-----...-----.-------.....---.--.-.-------.....--.----DSLSDLFNNVKQSIVSGKA..DYLDVLKDIFSNYMNFVNEL.R.QTISNL.NKYQ.KAGS.KEGTVNFDFKSFFNDLSNIRDKYknptgtvddPFVFKSRLFFQ..HQK..D..GTyLR.....TIDG.QEV-.HYsdL....QQVN--NAadalekllkginGISV..SIQRRGGE..PDVDidcrgrI......DCTDLEK.......LLNDL.SKKVS.........NT.D-DINQTEFELFRKTIDALDKKINTNL....DELSKKYSTANSNYDNFVKIVSSTMNTLLEMAKGFL..................................
D4HX51_ERWAC/297-370                 ........................................................................................................................ktthnvypdg----------------------------------------------------------------------------.....-------------------...---------..-..-----...-----.-------.....---.--.-.-------.....--.-----------------------..--------------------.-.------.----.----.-----------------------.........-----------..---..-..--.--.....----.----.--..-....--------............----..--------..----......-......-------.......-----.----S.........GG.EV--STVSYQAWLATFNAAGSALQSNM....QSFAQRYTQANNTFDNLNKVLSSVISTLGESAKDV-l.................................
C0AR40_9GAMM/32-128                  .............................................................................................................................eiyfk----------------------------------------------------------------------------.....-------------------...---------..-..-----...-----.-------.....---.--.-.-------.....--.-----------------------..--------------------.-.------.----.----.-----------------------.........-----------..---..-..--.--.....----.----.--..-....--------............----..--------..----......V......DLSRFDK.......LLDLV.LGGSSedemnkspdNA.TVKLLSSEFNLLKNGMDAFEKNINSNL....DELSKKYSAANSNYDNFVKIVSSTMNTLLEMAKGFL..................................
A0A0M9GH54_9PSED/122-322             ...........................................................................................................................plpqapt----------------------------------------------------------------------------.....-------------------...---------..-..-----...-----.-------.....---.--.-.-------.....--.---------FFDKLIELINLIGE..RYLNIYKDIVDKFSAFFDAFnS.QITSKL.QQWM.EAVN.EGKDIELDVGELKKALEALLAEL.........-----DDELF-..---..-..--.--.....KGSK.EDAA.KW..C....EALGLPAS............---C..LRDNGDGT..WSVL......I......DRSPLTQ.......MIEDL.VALKAg.......kDG.KVVLDSASFQAWQTGFNAQTERLKNKL....QELTQKYSSANTTYDNFIKVLSNHINQFTEMLK---am................................
A0A010S6L8_PSEFL/110-359             .....................................................................................rhcqktllpgdlqkleakqdfilgdlksnqaspaeiadefyvivk----------------------------------------------------------------------------.....-------------------...---------..-..-----...-----.-------.....---.--.-.-------.....--.-----SSNDFFDKLLELIDLIKN..GYLAGYEHIIAAYSDFFADF.NkEITAKM.KEWI.EGAN.DGKEVKLNAGMIRLALQALIEKY.........-SKAPAGVLFP..AP-..-..-G.ME.....GASK.EAAE.KW..R....VALGLPES............---C..LKDNGNGT..FSVV......M......DLGPLKI.......MMDS-.--LPS.........NVyWITWDTSKFQAWQTGFNAQEERLKNML....QSFTQKYSNANSYHDNFNKTLSSHLNQYADMLKA--ml................................
V5UEP0_9BURK/1-204                   .................................................................................................................................m----------------------------------------------------------------------------.....-------------------...---------..-..-----...-----.-------.....---.--.-.-------.....--.--------------ADLIGDIKD..GYLDVYSEAVAKYLAFNKAL.S.DLISKL.SGWI.STSS.DGKEVTLNIGELRKALNDILAEF.........KPPNKNSVLYP..KQDkdS..ND.IE.....GGTK.EDAE.KW..A....RDFGLPES............-SVQ..EQPEGSGK..WVVV......I......DTSPIDR.......MLDSI.PKDGD.........EK.K--MNPFELDIWRSGFTSQENQVKTMM....QQLMQRYTTANSTYDNLVKVLSSTIASTLEVAKGFL..................................
Q7NUT0_CHRVO/40-397                  .................................................................................................................................a-PQGSAA-PALAAARAKADELGQAAREVRASVE--------------RQTAYETRLAAQRSAAAFSGGEPPQARRE.....APGAELDEARNAQTVSARL...FEGNLKGVA..Q..SGHAM...SAEQK.QALQSGLddvfaDAP.PQ.A.RSAGAPMlysanAA.AGQGMADSDLWDMISDQIGKIKD..NYLGVYENVVGQYTDFYKAF.S.DILSQM.ANWI.KPGG.DGNKVKLNVDALKAALEKLKKDFsl.....gdNLDNKKAVLFP..AQS.kD..GG.IQ.....GGSE.SDAR.KW..A....KEMGLPDAp.........ppGFSC..VQKAADGN..WVVV......V......DMTPIDT.......MIRDV.GALGS.........GT.ELELDNAKFQAWQSGFKAQEENLKNTL....QTLTQKYSNANSLFDNLVKVLSSTISSCLETAKSFL..................................
#=GR Q7NUT0_CHRVO/40-397       SS    .................................................................................................................................X-XXXXXX--THHHHHHHHHHHHHHHHHHHHHHH--------------HHHHHHHHHHHHHHHHHHSS-S-------.....-S--TTTTHHHHHHHHHHH...HHHHHHHHH..H..S----...-HHHH.HHHHHHHHHHHSS--.HH.H.HTTSHHHHHHHHHH.HHT---HHHHHHHHHHHHHHHHH..HTHHHHHHHHHHHHHHHHHH.H.HHHHHH.GGG-.----.--------HHHHHHHHHHHHHHTS-.....-TTS--STTEEES..---.SS..S-.--.....-B-H.HHHH.HH..H....HHTT-----.........TTS--S..EEE-TTSS..EEEE......-......--HHHHH.......HHHHH.HHT--.........--.-----TTTHHHHHHHHHHHHHHHHHHH....HHHHHHHHHHHHHHHHHHHHHHHHHHHHH--XXXXX..................................
A0A0T9WZ48_SALET/5-341               ..................................................................................................................................QNYSASPHPGIVAERPQTP---SASEHVETAVVPSTTEHRGTDIISLSQAATKIQQAQQTLQS-------------.....TPPIS-EENNDERTLARQQ...LTSSLNALA..K..SGVSL...SAEQN.ENLRSAF.....SAP.TS.A.LFSASPM.....AQ.PRTTISDAEIWDMVSQNISAIGD..SYLGVYENVVAVYTDFYQAF.S.DILSKM.GGWL.LPGK.DGNTVKLDVTSLKNDLNSLVNKY.........NQINSNTVLFP..AQS..G..SG.VK.....VATE.AEAR.QW..L....SELNLPNS............----..CLKSYGSG..YVVT......V......DLTPLQK.......MVQDI.DGLGAp......gkDS.KLEMDNAKYQAWQSGFKAQEENMKTTL....QTLTQKYSNANSLYDNLVKVLSSTISSSLETAKSFL..................................
G2H1Q8_9ENTR/3-163                   .....................................................................................................................ksiaevkksaanm----------------------------------------------------------------------------.....-------------------...---------..-..-----...-----.-------.....---.--.-.-------.....--.----NAGVDMYDRIVNIIKSMSD..NSMKPTGDAAMKYTKFNTAV.S.NFIADM.NKLT.K--N.EGSNVVMDRFKVEQQLRQLMKDY.........SADQEAGILYT..VDT..-..AK.QS.....EDNE.AIAK.KK..A....EDLGLDPA............---K..VVKQKGNK..WLVT......L......DTSPLDK.......MLEL-.-----.........--.---------------------------....------------------------------------lpeysdknnke.......................
Q2NX44_SODGM/91-385                  .....................................................................................................srvqdilkkiellspsltridssepdsie----------------------------------------------------------------------------.....----SLKRRQKESAKAASE...LSEALQGEI..R..KESFI...RQKNY.NTLNHII....eEVK.QE.PnLEEAYNI....yLK.DETQLTYSEFWASIAATIASIKT..NYVDFYSSLMLQYADFYQAY.T.ELQSKA.AGAV.SEGK.DGNYIKWDNDVMDSAFKEFENKI.........ASLNNNLGTVP..QWD..-..--.--.....QLSD.TEHQ.QM..A....DTLK-PAF............----..AVDMETGK..--IT......F......DQSALSA.......CPKSP.SGGSG.........SG.KSDVDMASYNAWLAAFNSMGNTFQSNM....QSFAQRYTQANSTFDNLNKVLSSSITALLECAKAFL..................................
A0A0X8GMF1_9BURK/281-354             ........................................................................................................................tknsgdwars----------------------------------------------------------------------------.....-------------------...---------..-..-----...-----.-------.....---.--.-.-------.....--.-----------------------..--------------------.-.------.----.----.-----------------------.........-----------..---..-..--.--.....----.----.--..-....--------............----..--------..----......-......-------.......-----.-----.........-S.GAKLNNAIFQAWQTSHSTQKEQIQSTV....QVLAEKFGRANSIYDNIVKVLSSMTSSLEEAAKN--al................................
Q326T1_SHIDS/1-330                   ..................................................................................................................................MNITTLTNSISTSSFSPNNTNGSSTETVNSDIKTTTSSHPVSSLTMLNDTLHNIRTTNQALKKDLSQKTLTKTSLEeialhSSQISMDVNKSAQL-----...----LDILS..K..KEYPI...NKDAR.ELLH---.....SAP.EE.A.ELDGYQM.....--.----ISHRELWDKIAKSINNINE..QYLKVYEHAVSSYTQMYQDF.S.AVLSSL.AGWI.SPGGnDGNSVKLQVNSLKAELTKLKEKY.........----EDKPLYP..ANN..-..--.--.....TVSK.EQAD.KW..L....TELG----............GTIG..TVSRKNGG..YVVN......I......NMSPIDN.......MLKSL.NNLGG.........NG.EVVLDNAKYQAWNAGFSAEDETMKNNL....QTLVQKYSNANSIFDNLVKVLSSTISSCTDTDKLFL..................................
A0A0F7D2K6_SERFO/290-494             ..................................................................................................................sllphatepwpsaddp----------------------------------------------------------------------------.....-------------------...---------..-..-----...-----.-------.....---.--.-.-------.....--.----SSSWEIHKELGQAIAEMDE..NYLQVYEDAVGKYTGFFDDV.N.NVLGSM.HKHL.STSE.SG-KIFIESE-FRDAVGETLRKW.........---ERDNVLID..GLN..-..--.--.....---P.SEAT.AW..A....ESIG-PLA............----..----YADG..TKVK......I......DLSALRE.......LQTTV.YDSTG.........D-.--WMSAHEFQAVNEALSVHKEKIQSNM....QTLIQKYSTANSTFDNLIKVLSSTIASLLESDKSFL..................................
A0A0L7T8B8_9GAMM/3-282               ......................................................................................................................alekqqidlsia----------------------------------------------------------------------------.....--QVK-VSNDNARLMLNRY...LASSEDQLR..R..GNMDLlthPDDAN.DELEYHL....mRQS.IQ.E.TLDDDIH.....HQ.ADDVLSGNELIEKHLETIRQMKI..NYLQVFSQAFDKMSEFYKAF.V.KLKGEL.STYL.SPGA.KEGELNFKNYDFAKEVQALIDRF.........--SGKNGQLFP..QAD.aD..GK.YG.....TTTL.TIAK.NW..L....EQLGLPSD............---C..LRGDAGSG..YWIQ......V......DLKPLEN.......IVKTL.TDLGSg......gpNT.PITLNSAKYNAWESGFYSHADGLQNSM....NLLTQKTTNASSAFDQRVLI----------------mnkft.............................
W0I4E9_9GAMM/264-351                 .............................................................................................................dkygqvkiddtayqnlpnepe----------------------------------------------------------------------------.....-------------------...---------..-..-----...-----.-------.....---.--.-.-------.....--.-----------------------..--------------------.-.------.----.----.-----------------------.........-----------..---..-..--.--.....----.----.--..-....--------............----..--------..----......-......-------.......-----.---GR.........DE.ENNVNMASYNAWMAAFNSMGNIFQNNM....QSTSQRYTQANSTFDNLNKVLSSTITALLECAKSFL..................................
W0HRN3_9GAMM/107-385                 ....................................................................................................................pttidssepdcves----------------------------------------------------------------------------.....-----LKRKQKESAKAASE...LSDNLTGEI..R..KETLI...RQSNF.NTLNRMI....eEVK.QEpN.LEEAYNI....yLK.DETELTYSEFWASIAATIASIKT..NYVDFYSSLMLQYADFYQAY.T.ELQSKA.AGAV.SEGK.DGNYIKWDESVMSEAFQDFKDKI.........NSLNDNLGTVP..QWD..-..--.--.....QLSE.TERQ.QM..A....DTLK-PAF............----..AVDMSTGK..--IS......F......NQDALNA.......CPTSP.SGASG.........SG.KSDVDMASYNAWLAAFNSMGNTFQSNM....QSFSQRYTQANSTFDNLNKVLSSSITALLECAKAFL..................................
D4I1Q2_ERWAC/310-379                 .......................................................................................................................gslpkgdgnqv----------------------------------------------------------------------------.....-------------------...---------..-..-----...-----.-------.....---.--.-.-------.....--.-----------------------..--------------------.-.------.----.----.-----------------------.........-----------..---..-..--.--.....----.----.--..-....--------............----..--------..----......-......-------.......-----.-----.........--.----PTASYHAWLATFNAAGSALQSNM....QSFAQRYSQSNSTFDQLNKVLSGVISTLGDSAR---evy...............................
D4I1Q2_ERWAC/110-284                 .............................................................lnskknaddviaeqknltainshfierisshlrkrsilhdkssvepslplelakdgypaiagevfsade----------------------------------------------------------------------------.....-------------------...---------..-..-----...-----.-------.....---.--.-.-------.....--.ITPGTSYAELWSKIAKAIASIRK..DYVEFYATLMKKYTDLYQSY.N.ENVQKAsSDAM.SAGK.DGNNISFNKDVMIKGYNKFKD--.........-----------..---..-..--.--.....----.----.--..-....--------............----..--------..----......-......-------.......-----.-----.........--.---------------------------....------------------------------------yaaridlgkvahwdkmssqerenmkl........
W8U1G3_YEREN/300-366                 ...........................................................................................................................sgmdgnk----------------------------------------------------------------------------.....-------------------...---------..-..-----...-----.-------.....---.--.-.-------.....--.-----------------------..--------------------.-.------.----.----.-----------------------.........-----------..---..-..--.--.....----.----.--..-....--------............----..--------..----......-......-------.......-----.-----.........--.---VSTASYQAWLASFNGGGSALQGNM....QSFAQRYTQANSTFDNLNKVLSGAIASLAESAKD--vi................................
A0A0X1T7B0_PSEAA/100-357             ....................................................................................lseqvadlprneelrqwqgqaitalieqldrepeiaglgakkteef----------------------------------------------------------------------------.....-------------------...---------..-..-----...-----.-------.....---.--.-.-------.....--.-------PDFFDKLIELIGIIGN..DYLKVYEHIVATYSGFFKAF.NeQITSKL.HEWI.KGAN.EGKDVELNVEELKKALDELIRQF.........-SQAPAGVLFPvpAKQ..D..EP.PN.....TANK.KQAQ.DW..I....DAMG---S............GR--..LVYLGGDN..YCVM......I......DLSALDS.......MVKRL.DDIPLee.....ikEG.KVTWNSAQFQSWQTGFNAQGEQLKNEL....QKLTQKYSSANSTHDNFIKTLSSHMSQFTDMLKAM-l.................................
SIPD_SALTY/5-341                     ..................................................................................................................................QNYSASPHPGIVAERPQTP---SASEHVETAVVPSTTEHRGTDIISLSQAATKIHQAQQTLQS-------------.....TPPIS-EENNDERTLARQQ...LTSSLNALA..K..SGVSL...SAEQN.ENLRSAF.....SAP.TS.A.LFSASPM.....AQ.PRTTISDAEIWDMVSQNISAIGD..SYLGVYENVVAVYTDFYQAF.S.DILSKM.GGWL.LPGK.DGNTVKLDVTSLKNDLNSLVNKY.........NQINSNTVLFP..AQS..G..SG.VK.....VATE.AEAR.QW..L....SELNLPNS............----..CLKSYGSG..YVVT......V......DLTPLQK.......MVQDI.DGLGAp......gkDS.KLEMDNAKYQAWQSGFKAQEENMKTTL....QTLTQKYSNANSLYDNLVKVLSSTISSSLETAKSFL..................................
#=GR SIPD_SALTY/5-341          SS    ..................................................................................................................................XXXXXXXXXXXXXXXXXXX---XXXXXXXXXXSXXSXSSHHHHHHHHHHHHHHHHHHHHHHHH-------------.....S-STS-HHHHHHHHHHHHH...HHHHHHHHH..C..TT---...-HHHH.HHHHHHT.....SS-.SS.T.TT-----.....--.------HHHHHHHHHHHHHHHHH..HTHHHHHHHHHHHHHHHHHH.H.HHHTTG.GGGE.EE-S.STTEEEE-HHHHHHHHHHHHHHH.........TS-STTTEEES..---..S..SS.--.....-B-H.HHHH.HH..H....HHHT--GG............----..GEEEETTE..EEEE......S......--HHHHH.......HHHHH.HHT---......STTS.SEEEEHHHHHHHHHHHHHHHHHHHHHH....HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC..................................
A9MF91_SALAR/5-338                   ..................................................................................................................................QNYSASPRPGLVAERPQTT---SASEHVEITAAPATTEHRGADIITLSQAATKAQQAQQTLRS-------------.....TLPVS-EENNDERTLARQQ...LTSSLHALT..K..SGVSL...SAEQN.EGLRSAF.....SAP.AV.A.LFSTAPM.....AQ.PRVTISDAEIWDMVSQNISAIGD..NYLGVYENVVAVYTDFYQAF.S.DILSKM.GTWL.APGK.DGNTVKLNVDALKSEIRSLVNKY.........NQVTKNTILFP..SQT..G..SG.VT.....TATK.AEAE.QW..I....KELNLPGS............----..CLKASGSG..YVVL......V......DTGPLNK.......MVSDL.NGIGS.........GS.ALELDNAKYQAWQAGFKAQEENLKTTL....QTLTQKYSNANSLYDNLVKVLSSTISSSLETAKSFL..................................
G5LSS3_SALET/1-39                    ..................................................................................................................................----------------------------------------------------------------------------.....-------------------...---------..-..-----...-----.-------.....---.--.-.-------.....--.-----------------------..--------------------.-.------.----.----.-----------------------.........-----------..---..-..--.--.....----.----.--..-....--------............----..--------..----......-......-------.......-----.-----.........--.------------------------TTL....QTLTQKYSNANSLYDNLVKVLSSTISSSLETAKSFL..................................
I0QL29_9GAMM/40-311                  ...............................................sevsnsvtsllvclrnyekfnlskdkshasfsnhllkqelvsfnvqlsqygaydnsafnaeiediakqynseciqagasqlea----------------------------------------------------------------------------.....-------------------...---------..-..-----...-----.-------.....---.--.-.-------.....--.---PFERKPFVDQICNIIDTTKL..EYYDAFERALAKYIEYYKKF.S.DIVAKM.SSYI.HSVD.DEGQLRYDFMDLKTSLIELQNDY.........TEHSENNILYP..KNW..D..DR.VN.....-VTH.EDAL.KW..T....KDMGLPNT............CIKT..ITDKITGKiyYVIN......I......DPSPLQT.......MIDNI.KH-GD.........KN.NYKLSNTEYQAWLTGFNAQEDQIKTTV....QSLTGRYGNA--------------------------..................................
A0A0F5JTX1_9BURK/372-597             .....................................................................................................mknvtqytiqslvsgesavdqamarmdel----------------------------------------------------------------------------.....-------------------...---------..-..-----...-----.-------.....---.--.-.-------.....--.---QKSDVAQYGGLKTSISEAKE..AIIDPYGQLVSEYMNYTQAV.T.DVMSDL.SSYV.TASD.DGSKVTFKANELRDDIQA---KL.........NTLSGWSITLP..GTA..-..--.--.....VLSS.---S.DW..S....SELK----............GNFK..ATSNPDGT..TTLT......L......DLTNLQG.......MHDSL.ANY-S.........DG.DIS--VTQYNAWYSGFSSQKDNVQNLS....QSIAEKFSKMNTTFDDLVRVMSSTITALLEAEQ---ksl...............................
A0A0T9KA61_9GAMM/6-405               nnhntvrfsehltvnsnetrqapaaavdeeaksarmttrqqvltktktkldallnsdkthqaaktlsgtlrdieqrqperaarlnafstegksqqdcdkqleillapdksdalartqldalratasdkss----------------------------------------------------------------------------.....---------LARRTLLIDS...ISKQLQTIA..QlaQENPE...DYDLT.DAAELQA.....AAP.RS.A.RSARSTD....pTE.KKDPISSWDIYQDLADAIGEMDD..SYLSVHEYAVKQYSDFFSDF.S.NLKSKL.QEFI.NSGK.DGNII-LNSGEIRKELDKLLAKYs.......vNPVTKAAVLFP..KQS.eT..GG.VK.....GASQ.EDAK.AW..A....SELGIDPN............--TC..VKQLPDGT..WVCT......I......DTSPLTK.......MKSDL.P---H.........NA.VEDMNSAKFQAWMAGFDAQAEKLQTAM....QSHLQKYSTASSTFDNLIKVLSSTISSLLETDKSF-f.................................
A0A0R0DEB9_9GAMM/12-245              ...................................................................................................................daepdnaqakltmqe----------------------------------------------------------------------------.....-------------------...---------..-..-----...---AR.RALQ--E.....RVP.QQ.L.LQD----.....AE.QRAGGSHADFFKEISGLIGRLDK..EWIGKYSGLLAGYVGFYREL.T.NALALI.KDQLgKPDK.DG-MVEVDFTALRTKLDDLKAKW.........-----------..AGQ..G..FG.EV.....FGTE.AAAR.RY..L....AEVGI--E............GLTV..VERKPGGG..WQIS......I......DPDLINS.......LQHVFpSTVGG.........IS.ASALNE---------MMAQKEIMLERFsfitRAIPEKYQRQLQMWDTLVKILSSTIDSTTQADQ---gvi...............................
#=GC SS_cons                         ...................................................................................................................HHHHHHHHHHHHHHHXXXXXXXXXTHHHHHHHHHHHHHHHHHHHHHHCXXSXSSHHHHHHHHHHHHHHHHHHHHHHHHHHSS-S-------.....SSSTTTCCHHHHHHHHHHH...HHHHHHHHH..C..TT---...-HHHH.HHHHHHCHHHHSSS-.CC.C.CTTSHHHHHHHHHH.HHT---HHHHHHHHHHHHHHHHH..HTHHHHHHHHHHHHHHHHHH.H.HHHHHG.GGGE.EECS.STTEEEE-HHHHHHHHHHHHHHCS.......TTS-STTTEEES..EE-.SS..SS.-E.....-BTH.HHHH.HH..H....HHHT--CC..........TTS--S..CEEECTTS..EEEE......C......--HHHHH.......HHHHH.HHT---......STTT.CEEEEHHHHHHHHHHHHHHHHHHHHHH....HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCC..................................
#=GC seq_cons                        ...........................................................................................................................t.....t............................................................................................................................................................................t..thht.ltp.Itthpp..pYlphYtplhtpYspaapsh.s.phhuph.sphl.psup.DGpplphshtthppthpphhpch.................hhs......................st.ttht.th..h....pphs...........................sut....l.......h......s.sslpt.......hhpt......s.........ss.t.thssspapAW.suasuttpphpssh....Qphsp+YopANShaDNLsKlLSuslss.h-.t+.....................................
//
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