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Database: Pfam
Entry: Kelch_5
LinkDB: Kelch_5
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#=GF ID   Kelch_5
#=GF AC   PF13854.1
#=GF DE   Kelch motif
#=GF AU   Coggill P
#=GF SE   Jackhmmer:A8MU55
#=GF GA   27.00 20.00;
#=GF TC   27.00 20.00;
#=GF NC   26.90 19.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Repeat
#=GF WK   Kelch_motif
#=GF RN   [1]
#=GF RM   8126718
#=GF RT   Drosophila kelch motif is derived from a common enzyme fold. 
#=GF RA   Bork P, Doolittle RF; 
#=GF RL   J Mol Biol 1994;236:1277-1282.
#=GF RN   [2]
#=GF RM   2002850
#=GF RT   Novel thioether bond revealed by a 1.7 A crystal structure of
#=GF RT   galactose oxidase. 
#=GF RA   Ito N, Phillips SE, Stevens C, Ogel ZB, McPherson MJ, Keen JN,
#=GF RA   Yadav KD, Knowles PF; 
#=GF RL   Nature 1991;350:87-90.
#=GF RN   [3]
#=GF RM   15475350
#=GF RT   Crystal structure of the Kelch domain of human Keap1. 
#=GF RA   Li X, Zhang D, Hannink M, Beamer LJ; 
#=GF RL   J Biol Chem 2004;279:54750-54758.
#=GF CC   The kelch motif was initially discovered in Kelch
#=GF CC   (Swiss:Q04652). In this protein there are six copies of the
#=GF CC   motif.  It has been shown that Swiss:Q04652 is related to
#=GF CC   Galactose Oxidase [1] for which a structure has been solved [2].
#=GF CC   The kelch motif forms a beta sheet.  Several of these sheets
#=GF CC   associate to form a beta propeller structure [3] as found in
#=GF CC   Pfam:PF00064, Pfam:PF00400 and Pfam:PF00415.
#=GF SQ   1509
#=GS D2VHZ4_NAEGR/512-554    AC D2VHZ4.1
#=GS A4S3K6_OSTLU/83-123     AC A4S3K6.1
#=GS Q7Q986_ANOGA/576-619    AC Q7Q986.3
#=GS Q4GZD6_TRYB2/80-119     AC Q4GZD6.1
#=GS A2D7V3_TRIVA/114-151    AC A2D7V3.1
#=GS G8T822_NIAKG/148-188    AC G8T822.1
#=GS E1BIV3_BOVIN/11-54      AC E1BIV3.1
#=GS Q4DFR3_TRYCC/457-493    AC Q4DFR3.1
#=GS F0ZQK7_DICPU/276-316    AC F0ZQK7.1
#=GS F2U744_SALS5/1045-1084  AC F2U744.1
#=GS I1GGN0_AMPQE/8-46       AC I1GGN0.1
#=GS A8J336_CHLRE/595-645    AC A8J336.1
#=GS D2VTV6_NAEGR/20-61      AC D2VTV6.1
#=GS Q7S983_NEUCR/202-245    AC Q7S983.1
#=GS B8PA06_POSPM/138-178    AC B8PA06.1
#=GS G4UM75_NEUT9/471-521    AC G4UM75.1
#=GS D4AYG1_ARTBC/325-369    AC D4AYG1.1
#=GS H6BJX5_EXODN/315-364    AC H6BJX5.1
#=GS I1C7F9_RHIO9/105-149    AC I1C7F9.1
#=GS H2QZQ6_PANTR/350-391    AC H2QZQ6.1
#=GS D3BE69_POLPA/365-405    AC D3BE69.1
#=GS KEL1_YEAST/178-222      AC P38853.1
#=GS E3SA34_PYRTT/313-358    AC E3SA34.1
#=GS H3A8T9_LATCH/287-335    AC H3A8T9.1
#=GS G2WXR9_VERDV/323-372    AC G2WXR9.1
#=GS B8C3S2_THAPS/451-484    AC B8C3S2.1
#=GS E5R0T9_ARTGP/332-376    AC E5R0T9.1
#=GS G0NF86_CAEBE/311-339    AC G0NF86.1
#=GS B4KBA1_DROMO/652-685    AC B4KBA1.1
#=GS I1FTV0_AMPQE/8-46       AC I1FTV0.1
#=GS G0NG88_CAEBE/334-378    AC G0NG88.1
#=GS E4XAC6_OIKDI/725-770    AC E4XAC6.1
#=GS H2ZX29_LATCH/477-519    AC H2ZX29.1
#=GS I1EHI6_AMPQE/8-46       AC I1EHI6.1
#=GS G2REX5_THITE/293-332    AC G2REX5.1
#=GS D2VI13_NAEGR/399-441    AC D2VI13.1
#=GS E6R701_CRYGW/28-72      AC E6R701.1
#=GS H6TIR0_PLEAT/148-185    AC H6TIR0.1
#=GS Q4Y8A4_PLACH/79-117     AC Q4Y8A4.1
#=GS E7FB15_DANRE/312-356    AC E7FB15.1
#=GS C9SR01_VERA1/498-535    AC C9SR01.1
#=GS A1CVB8_NEOFI/293-342    AC A1CVB8.1
#=GS G2QKU5_THIHA/323-372    AC G2QKU5.1
#=GS B2AAL6_PODAN/526-563    AC B2AAL6.1
#=GS I1FSP4_AMPQE/14-52      AC I1FSP4.1
#=GS I1ET25_AMPQE/10-42      AC I1ET25.1
#=GS F7W0K6_SORMK/230-279    AC F7W0K6.1
#=GS H3GSZ4_PHYRM/382-435    AC H3GSZ4.1
#=GS G0J1F7_CYCMS/200-235    AC G0J1F7.1
#=GS G2RDZ9_THITE/320-369    AC G2RDZ9.1
#=GS E1BN42_BOVIN/253-295    AC E1BN42.1
#=GS B7PD33_IXOSC/24-66      AC B7PD33.1
#=GS C0NEZ4_AJECG/90-133     AC C0NEZ4.1
#=GS Q5B7F0_EMENI/186-230    AC Q5B7F0.1
#=GS C5K0S8_AJEDS/91-134     AC C5K0S8.1
#=GS B2B4U8_PODAN/284-333    AC B2B4U8.1
#=GS F7GD86_ORNAN/525-560    AC F7GD86.1
#=GS H0GHJ5_9SACH/52-93      AC H0GHJ5.1
#=GS E9GTI5_DAPPU/94-140     AC E9GTI5.1
#=GS I1C7F9_RHIO9/163-204    AC I1C7F9.1
#=GS I0YSA2_9CHLO/381-421    AC I0YSA2.1
#=GS I1EQ47_AMPQE/8-46       AC I1EQ47.1
#=GS A4HDA5_LEIBR/120-158    AC A4HDA5.1
#=GS Q6PE06_MOUSE/81-124     AC Q6PE06.1
#=GS Q22GW3_TETTS/46-86      AC Q22GW3.2
#=GS B6QAX8_PENMQ/193-234    AC B6QAX8.1
#=GS E4V2J4_ARTGP/311-360    AC E4V2J4.1
#=GS H1NQQ6_9SPHI/128-170    AC H1NQQ6.1
#=GS ATRN1_MOUSE/578-613     AC Q6A051.2
#=GS G6DGP4_DANPL/153-199    AC G6DGP4.1
#=GS A9S0K3_PHYPA/531-569    AC A9S0K3.1
#=GS A4I0N8_LEIIN/220-258    AC A4I0N8.1
#=GS G0S3I3_CHATD/207-255    AC G0S3I3.1
#=GS C9IZD4_HUMAN/390-436    AC C9IZD4.1
#=GS B9PUB3_TOXGO/600-638    AC B9PUB3.1
#=GS Q3V0X6_MOUSE/381-419    AC Q3V0X6.1
#=GS A7ECC6_SCLS1/189-232    AC A7ECC6.1
#=GS C7GJY0_YEAS2/233-277    AC C7GJY0.1
#=GS D8TFB3_SELML/15-52      AC D8TFB3.1
#=GS B2B6L4_PODAN/260-309    AC B2B6L4.1
#=GS A1DE23_NEOFI/459-504    AC A1DE23.1
#=GS A0BMK6_PARTE/78-119     AC A0BMK6.1
#=GS F7GD86_ORNAN/297-339    AC F7GD86.1
#=GS F4QE89_DICFS/379-419    AC F4QE89.1
#=GS G1NKN8_MELGA/255-292    AC G1NKN8.2
#=GS B6AER9_CRYMR/354-391    AC B6AER9.1
#=GS LZTR1_MOUSE/381-419     AC Q9CQ33.2
#=GS I1CFQ1_RHIO9/167-214    AC I1CFQ1.1
#=GS E7L4G5_TRYCR/400-436    AC E7L4G5.1
#=GS G3ST47_LOXAF/315-359    AC G3ST47.1
#=GS G4MUZ0_MAGO7/92-133     AC G4MUZ0.1
#=GS G0L2Y0_ZOBGA/305-342    AC G0L2Y0.1
#=GS H9JTS0_BOMMO/288-328    AC H9JTS0.1
#=GS A2E7W9_TRIVA/123-160    AC A2E7W9.1
#=GS G4UJZ6_NEUT9/323-369    AC G4UJZ6.1
#=GS H9K1C9_APIME/83-129     AC H9K1C9.1
#=GS G0QZ44_ICHMG/4-44       AC G0QZ44.1
#=GS E0VTG2_PEDHC/319-361    AC E0VTG2.1
#=GS B3LI02_YEAS1/194-237    AC B3LI02.1
#=GS G5B4U1_HETGA/268-306    AC G5B4U1.1
#=GS Q4W972_ASPFU/335-384    AC Q4W972.1
#=GS H3DEP2_TETNG/362-400    AC H3DEP2.1
#=GS D2VTV6_NAEGR/318-359    AC D2VTV6.1
#=GS I1EEU0_AMPQE/25-58      AC I1EEU0.1
#=GS Q1HA67_GLOLA/292-331    AC Q1HA67.1
#=GS Q22GW3_TETTS/311-348    AC Q22GW3.2
#=GS D2HUK5_AILME/399-437    AC D2HUK5.1
#=GS A5D6R2_DANRE/317-366    AC A5D6R2.1
#=GS C0SJD5_PARBP/312-361    AC C0SJD5.1
#=GS G3P3Z9_GASAC/334-372    AC G3P3Z9.1
#=GS Q960R8_DROME/504-538    AC Q960R8.1
#=GS I1CEB7_RHIO9/143-188    AC I1CEB7.1
#=GS E1FYH1_LOALO/135-169    AC E1FYH1.1
#=GS LZTR1_PONAB/384-422     AC Q5R4Q7.1
#=GS H0XM56_OTOGA/365-403    AC H0XM56.1
#=GS F2PIU8_TRIEC/257-294    AC F2PIU8.1
#=GS A0D2Q7_PARTE/97-136     AC A0D2Q7.1
#=GS E4YE85_OIKDI/238-276    AC E4YE85.1
#=GS G1S2W1_NOMLE/350-391    AC G1S2W1.1
#=GS C5GF81_AJEDR/333-383    AC C5GF81.1
#=GS I1ESP3_AMPQE/59-97      AC I1ESP3.1
#=GS D2VX49_NAEGR/314-352    AC D2VX49.1
#=GS C1H1X4_PARBA/328-378    AC C1H1X4.1
#=GS C1MGG3_MICPC/277-325    AC C1MGG3.1
#=GS D2VZV1_NAEGR/262-302    AC D2VZV1.1
#=GS F8MZM5_NEUT8/306-355    AC F8MZM5.1
#=GS H2SSL3_TAKRU/432-474    AC H2SSL3.1
#=GS Q4U9W8_THEAN/245-284    AC Q4U9W8.1
#=GS H2UV34_TAKRU/356-394    AC H2UV34.1
#=GS G4MXK3_MAGO7/207-248    AC G4MXK3.1
#=GS E6ZHA4_DICLA/567-602    AC E6ZHA4.1
#=GS Q2QP63_ORYSJ/58-95      AC Q2QP63.2
#=GS B9I9Z0_POPTR/95-135     AC B9I9Z0.1
#=GS Q2U9P3_ASPOR/266-313    AC Q2U9P3.1
#=GS Q6C2P9_YARLI/249-288    AC Q6C2P9.1
#=GS A4HZX5_LEIIN/499-563    AC A4HZX5.1
#=GS E5R060_ARTGP/260-297    AC E5R060.1
#=GS G4NJU5_MAGO7/296-346    AC G4NJU5.1
#=GS A0D2Q7_PARTE/38-67      AC A0D2Q7.1
#=GS H0WZN5_OTOGA/350-391    AC H0WZN5.1
#=GS A1CLX0_ASPCL/303-352    AC A1CLX0.1
#=GS F7DWF4_XENTR/66-105     AC F7DWF4.1
#=GS Q9C6A4_ARATH/71-110     AC Q9C6A4.1
#=GS H3IQ71_STRPU/9-61       AC H3IQ71.1
#=GS H3DIP0_TETNG/21-65      AC H3DIP0.1
#=GS D2A260_TRICA/72-109     AC D2A260.1
#=GS F7GEG5_MONDO/312-356    AC F7GEG5.1
#=GS B3N6Z6_DROER/226-267    AC B3N6Z6.1
#=GS Q16GK5_AEDAE/271-308    AC Q16GK5.1
#=GS D0N9L6_PHYIT/1222-1260  AC D0N9L6.1
#=GS I1FVA1_AMPQE/146-175    AC I1FVA1.1
#=GS I1E7J3_AMPQE/6-38       AC I1E7J3.1
#=GS C9S983_VERA1/285-334    AC C9S983.1
#=GS G4MQ05_MAGO7/249-298    AC G4MQ05.1
#=GS B0XRN0_ASPFC/321-366    AC B0XRN0.1
#=GS B8C0A8_THAPS/257-293    AC B8C0A8.1
#=GS E5A373_LEPMJ/191-234    AC E5A373.1
#=GS F0W0R4_9STRA/202-240    AC F0W0R4.1
#=GS B2B4L3_PODAN/48-77      AC B2B4L3.1
#=GS G3V5V5_HUMAN/11-54      AC G3V5V5.1
#=GS E2BUY3_HARSA/451-490    AC E2BUY3.1
#=GS G2XRQ3_BOTF4/327-376    AC G2XRQ3.1
#=GS C6LW50_GIAIB/117-158    AC C6LW50.1
#=GS E1ZNV5_CHLVA/421-458    AC E1ZNV5.1
#=GS H6TIM5_9TELE/148-185    AC H6TIM5.1
#=GS F7WBN8_SORMK/329-378    AC F7WBN8.1
#=GS G0MB76_CAEBE/318-363    AC G0MB76.1
#=GS F7E9B5_XENTR/238-279    AC F7E9B5.1
#=GS D3W8L2_9BACT/211-247    AC D3W8L2.1
#=GS B6AER4_CRYMR/191-234    AC B6AER4.1
#=GS C7YIF6_NECH7/291-329    AC C7YIF6.1
#=GS B4M877_DROVI/178-221    AC B4M877.1
#=GS F9G3I5_FUSOF/266-314    AC F9G3I5.1
#=GS F7IID9_CALJA/11-54      AC F7IID9.1
#=GS F6QXI1_HORSE/205-246    AC F6QXI1.1
#=GS H2LJV7_ORYLA/536-571    AC H2LJV7.1
#=GS G1NLT7_MELGA/29-77      AC G1NLT7.1
#=GS G2WFN1_YEASK/233-277    AC G2WFN1.1
#=GS I1EK14_AMPQE/19-51      AC I1EK14.1
#=GS E6ZSS3_SPORE/94-127     AC E6ZSS3.1
#=GS Q8IJL6_PLAF7/770-823    AC Q8IJL6.2
#=GS A5DK23_PICGU/319-359    AC A5DK23.2
#=GS A6ZT66_YEAS7/233-277    AC A6ZT66.1
#=GS B8C3S2_THAPS/323-361    AC B8C3S2.1
#=GS E6PYP9_9ZZZZ/204-245    AC E6PYP9.1
#=GS D8TFD7_SELML/105-150    AC D8TFD7.1
#=GS F8QAB8_SERL3/285-322    AC F8QAB8.1
#=GS D0NCZ5_PHYIT/390-427    AC D0NCZ5.1
#=GS H3GSZ4_PHYRM/251-289    AC H3GSZ4.1
#=GS I1NKI9_ORYGL/649-683    AC I1NKI9.1
#=GS G4N502_MAGO7/256-300    AC G4N502.1
#=GS I1EBL5_AMPQE/14-55      AC I1EBL5.1
#=GS E7NIP8_YEASO/233-277    AC E7NIP8.1
#=GS G3SSV4_LOXAF/173-216    AC G3SSV4.1
#=GS E3Q3F2_COLGM/500-537    AC E3Q3F2.1
#=GS I1GE43_AMPQE/20-51      AC I1GE43.1
#=GS D7FP81_ECTSI/309-348    AC D7FP81.1
#=GS E4ZGS9_LEPMJ/318-384    AC E4ZGS9.1
#=GS F9FFB1_FUSOF/149-200    AC F9FFB1.1
#=GS E1FYH1_LOALO/82-123     AC E1FYH1.1
#=GS A6RP54_BOTFB/189-232    AC A6RP54.1
#=GS Q5BCN8_EMENI/304-345    AC Q5BCN8.1
#=GS F7EST9_XENTR/284-333    AC F7EST9.1
#=GS A6SG93_BOTFB/327-376    AC A6SG93.1
#=GS E7KPJ9_YEASL/178-222    AC E7KPJ9.1
#=GS H9GEZ3_ANOCA/255-297    AC H9GEZ3.1
#=GS C9SR01_VERA1/305-344    AC C9SR01.1
#=GS D0N080_PHYIT/83-120     AC D0N080.1
#=GS F1SRK9_PIG/312-356      AC F1SRK9.1
#=GS F1MXV1_BOVIN/309-350    AC F1MXV1.2
#=GS F7HUQ6_CALJA/312-356    AC F7HUQ6.1
#=GS G1NF70_MELGA/578-613    AC G1NF70.2
#=GS G5B966_HETGA/11-53      AC G5B966.1
#=GS G3AGV3_SPAPN/276-316    AC G3AGV3.1
#=GS A0D9R2_PARTE/323-361    AC A0D9R2.1
#=GS G4UB37_NEUT9/161-202    AC G4UB37.1
#=GS I1FN03_AMPQE/8-57       AC I1FN03.1
#=GS D2GX18_AILME/548-583    AC D2GX18.1
#=GS A2WL21_ORYSI/639-673    AC A2WL21.1
#=GS A7F8S8_SCLS1/327-376    AC A7F8S8.1
#=GS C9ZHV9_TRYB9/80-119     AC C9ZHV9.1
#=GS Q6NP06_DROME/61-100     AC Q6NP06.1
#=GS E3Q3F2_COLGM/289-328    AC E3Q3F2.1
#=GS G4NK26_MAGO7/281-329    AC G4NK26.1
#=GS C7E144_ALLCE/321-361    AC C7E144.1
#=GS Q6FR02_CANGA/273-314    AC Q6FR02.1
#=GS H2LEI3_ORYLA/426-465    AC H2LEI3.1
#=GS G9NMN7_HYPAI/254-303    AC G9NMN7.1
#=GS F0XGV1_GROCL/290-339    AC F0XGV1.1
#=GS D6X316_TRICA/262-305    AC D6X316.1
#=GS B5DFI4_RAT/381-419      AC B5DFI4.1
#=GS G4MZZ1_MAGO7/325-374    AC G4MZZ1.1
#=GS E7LVJ7_YEASV/178-222    AC E7LVJ7.1
#=GS H9G305_CAEEL/73-96      AC H9G305.1
#=GS C1MIV4_MICPC/459-507    AC C1MIV4.1
#=GS Q29BH4_DROPS/647-681    AC Q29BH4.2
#=GS E1BYK5_CHICK/354-395    AC E1BYK5.1
#=GS C6LNP2_GIAIB/299-336    AC C6LNP2.1
#=GS B6Q4Q0_PENMQ/475-516    AC B6Q4Q0.1
#=GS F9G601_FUSOF/189-235    AC F9G601.1
#=GS Q2KEH0_MAGO7/343-391    AC Q2KEH0.1
#=GS E2BBL6_HARSA/306-351    AC E2BBL6.1
#=GS F2PJ69_TRIEC/326-375    AC F2PJ69.1
#=GS E1C2T2_CHICK/13-56      AC E1C2T2.1
#=GS F8MJL3_NEUT8/273-320    AC F8MJL3.1
#=GS Q4D190_TRYCC/258-299    AC Q4D190.1
#=GS E7KPJ9_YEASL/121-162    AC E7KPJ9.1
#=GS C4Y5L2_CLAL4/338-378    AC C4Y5L2.1
#=GS D0N9M1_PHYIT/1384-1422  AC D0N9M1.1
#=GS H2LEI1_ORYLA/475-514    AC H2LEI1.1
#=GS I1HEU0_BRADI/296-335    AC I1HEU0.1
#=GS E3KMG5_PUCGT/210-246    AC E3KMG5.2
#=GS Q9VLT6_DROME/232-273    AC Q9VLT6.3
#=GS G0W9W3_NAUDC/227-271    AC G0W9W3.1
#=GS D0N9L4_PHYIT/738-789    AC D0N9L4.1
#=GS H2UV36_TAKRU/345-383    AC H2UV36.1
#=GS F0VYQ0_9STRA/200-261    AC F0VYQ0.1
#=GS H2ZPI2_CIOSA/66-107     AC H2ZPI2.1
#=GS E9C2A1_CAPO3/403-442    AC E9C2A1.1
#=GS F8NE53_SERL9/208-247    AC F8NE53.1
#=GS B4KEC1_DROMO/226-267    AC B4KEC1.1
#=GS D0N9M1_PHYIT/1142-1193  AC D0N9M1.1
#=GS H9KL48_APIME/349-388    AC H9KL48.1
#=GS I1EY72_AMPQE/8-45       AC I1EY72.1
#=GS D6X2Y0_TRICA/162-201    AC D6X2Y0.1
#=GS Q53FE7_HUMAN/312-356    AC Q53FE7.1
#=GS E0VUD0_PEDHC/291-331    AC E0VUD0.1
#=GS Q16NC7_AEDAE/576-619    AC Q16NC7.1
#=GS G0R989_HYPJQ/328-377    AC G0R989.1
#=GS D0N605_PHYIT/173-214    AC D0N605.1
#=GS F7EHC5_XENTR/328-368    AC F7EHC5.1
#=GS G4N905_MAGO7/234-282    AC G4N905.1
#=GS HCFC2_RAT/312-356       AC Q5RKG2.1
#=GS E6ZHA4_DICLA/337-379    AC E6ZHA4.1
#=GS H9FPS3_MACMU/11-54      AC H9FPS3.1
#=GS G9K942_MUSPF/298-336    AC G9K942.1
#=GS B8ML95_TALSN/354-403    AC B8ML95.1
#=GS H0XF42_OTOGA/11-54      AC H0XF42.1
#=GS Q6NRT1_XENLA/315-353    AC Q6NRT1.1
#=GS F1KQI4_ASCSU/544-578    AC F1KQI4.1
#=GS E7L7B3_TRYCR/129-168    AC E7L7B3.1
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G3TRQ3_LOXAF/485-520               ...............................................vn--.--..RFG.HSA.V.......................V.I.......N................GS......................M.YI........FG..G..FS...................-........--SVL..........L......N.D...IL.....VY..KPP--n..................................
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#=GC seq_cons                      ..................................................P..s..Rhs.Hss.s.......................s.h.......s................sp......................l.al........aG..G..hs.............................psth..........h......s.D...la.....hh..sh......................................
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