GenomeNet

Database: Pfam
Entry: L27_2
LinkDB: L27_2
Original site: L27_2 
#=GF ID   L27_2
#=GF AC   PF09045.6
#=GF DE   L27_2
#=GF AU   Mistry J, Sammut SJ
#=GF SE   pdb_1y76
#=GF GA   20.90 20.90;
#=GF TC   21.00 21.30;
#=GF NC   20.80 19.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   L27_domain
#=GF RN   [1]
#=GF RM   15863617
#=GF RT   A unified assembly mode revealed by the structures of tetrameric
#=GF RT   L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1
#=GF RT   scaffold proteins. 
#=GF RA   Feng W, Long JF, Zhang M; 
#=GF RL   Proc Natl Acad Sci U S A. 2005;102:6861-6866.
#=GF DR   INTERPRO; IPR015132;
#=GF CC   The L27_2 domain is a protein-protein interaction domain capable
#=GF CC   of organising scaffold proteins into supramolecular assemblies
#=GF CC   by formation of heteromeric L27_2 domain complexes. L27_2
#=GF CC   domain-mediated protein assemblies have been shown to play
#=GF CC   essential roles in cellular processes including asymmetric cell
#=GF CC   division, establishment and maintenance of cell polarity, and
#=GF CC   clustering of receptors and ion channels. Members of this family
#=GF CC   form specific heterotetrameric complexes, in which each domain
#=GF CC   contains three alpha-helices. The two N-terminal helices of each
#=GF CC   L27_2 domain pack together to form a tight, four-helix bundle in
#=GF CC   the heterodimer, whilst the third helix of each L27_2 domain
#=GF CC   forms another four-helix bundle that assembles the two units of
#=GF CC   the heterodimer into a tetramer [1].
#=GF SQ   156
#=GS F6T1W3_MACMU/7-64     AC F6T1W3.1
#=GS A7SRG3_NEMVE/6-63     AC A7SRG3.1
#=GS F7HHK2_CALJA/6-63     AC F7HHK2.1
#=GS F7C8K6_CALJA/6-63     AC F7C8K6.1
#=GS Q1LXN3_DANRE/12-69    AC Q1LXN3.2
#=GS H2PS57_PONAB/6-63     AC H2PS57.1
#=GS F1PGB9_CANFA/6-63     AC F1PGB9.2
#=GS G1JT17_CHICK/6-63     AC G1JT17.1
#=GS M4A8E4_XIPMA/12-69    AC M4A8E4.1
#=GS K9J409_DESRO/8-65     AC K9J409.1
#=GS MPDZ_HUMAN/6-63       AC O75970.2
#=GS I3MPP0_SPETR/8-65     AC I3MPP0.1
#=GS W5PGV1_SHEEP/8-65     AC W5PGV1.1
#=GS F1N9G0_CHICK/6-63     AC F1N9G0.2
#=GS H3AIS3_LATCH/6-63     AC H3AIS3.1
#=GS G5AP53_HETGA/6-63     AC G5AP53.1
#=GS W5PWP7_SHEEP/6-63     AC W5PWP7.1
#=GS H2LIZ8_ORYLA/2-56     AC H2LIZ8.1
#=GS F1MMT3_BOVIN/21-78    AC F1MMT3.2
#=GS G1RY01_NOMLE/8-65     AC G1RY01.1
#=GS D3ZKZ2_RAT/8-65       AC D3ZKZ2.1
#=GS W5LF57_ASTMX/12-69    AC W5LF57.1
#=GS W5MUV5_LEPOC/12-69    AC W5MUV5.1
#=GS INADL_MOUSE/8-65      AC Q63ZW7.2
#=GS INADL_MOUSE/8-65      DR PDB; 3UIT A; 8-65;
#=GS INADL_MOUSE/8-65      DR PDB; 3UIT C; 9-65;
#=GS INADL_MOUSE/8-65      DR PDB; 3UIT B; 9-65;
#=GS INADL_MOUSE/8-65      DR PDB; 3UIT D; 8-65;
#=GS G3TKC2_LOXAF/6-63     AC G3TKC2.1
#=GS H2LHB5_ORYLA/6-63     AC H2LHB5.1
#=GS K7DKU2_PANTR/8-65     AC K7DKU2.1
#=GS K1R7T1_CRAGI/11-67    AC K1R7T1.1
#=GS J3S4I8_CROAD/8-65     AC J3S4I8.1
#=GS F7I9N8_CALJA/8-65     AC F7I9N8.1
#=GS V9K7M9_CALMI/6-63     AC V9K7M9.1
#=GS F7FYD6_CALJA/6-63     AC F7FYD6.1
#=GS F1PGC1_CANFA/6-63     AC F1PGC1.2
#=GS G1NGL1_MELGA/8-65     AC G1NGL1.1
#=GS M3WF73_FELCA/2-59     AC M3WF73.1
#=GS K7FFA6_PELSI/8-65     AC K7FFA6.1
#=GS T1INI3_STRMM/1-58     AC T1INI3.1
#=GS H2RX16_TAKRU/10-67    AC H2RX16.1
#=GS D3YUX2_MOUSE/6-63     AC D3YUX2.1
#=GS M4ACC1_XIPMA/6-56     AC M4ACC1.1
#=GS I3JQI1_ORENI/5-57     AC I3JQI1.1
#=GS K7E7G9_ORNAN/8-65     AC K7E7G9.1
#=GS G7PSC6_MACFA/7-64     AC G7PSC6.1
#=GS H2YMG8_CIOSA/6-63     AC H2YMG8.1
#=GS G3S205_GORGO/6-63     AC G3S205.1
#=GS S9XL16_9CETA/7-64     AC S9XL16.1
#=GS H3CK11_TETNG/47-103   AC H3CK11.1
#=GS W5PWQ2_SHEEP/6-63     AC W5PWQ2.1
#=GS G7MHB0_MACMU/8-65     AC G7MHB0.1
#=GS T2M9I3_HYDVU/1-57     AC T2M9I3.1
#=GS A2ADS6_MOUSE/8-65     AC A2ADS6.1
#=GS H9G1B4_MACMU/6-63     AC H9G1B4.1
#=GS G1SLR4_RABIT/6-63     AC G1SLR4.2
#=GS F6RHB2_MONDO/6-63     AC F6RHB2.1
#=GS W4YY52_STRPU/190-247  AC W4YY52.1
#=GS MPDZ_MOUSE/6-63       AC Q8VBX6.2
#=GS H0WLW5_OTOGA/8-65     AC H0WLW5.1
#=GS D2HP61_AILME/1-58     AC D2HP61.1
#=GS H2R430_PANTR/6-63     AC H2R430.1
#=GS W5UKL3_ICTPU/12-69    AC W5UKL3.1
#=GS G3WB42_SARHA/6-63     AC G3WB42.1
#=GS G5BSM7_HETGA/8-65     AC G5BSM7.1
#=GS H0WTI1_OTOGA/6-63     AC H0WTI1.1
#=GS V8NUY1_OPHHA/15-72    AC V8NUY1.1
#=GS D2H2X4_AILME/6-63     AC D2H2X4.1
#=GS G1KL12_ANOCA/6-63     AC G1KL12.2
#=GS M3W3U3_FELCA/8-65     AC M3W3U3.1
#=GS H2N774_PONAB/8-65     AC H2N774.1
#=GS W5N6S3_LEPOC/6-63     AC W5N6S3.1
#=GS F6T1X2_MACMU/7-64     AC F6T1X2.1
#=GS U3I527_ANAPL/8-65     AC U3I527.1
#=GS G3PTR0_GASAC/11-62    AC G3PTR0.1
#=GS L8Y8X5_TUPCH/7-63     AC L8Y8X5.1
#=GS F7IC28_CALJA/8-65     AC F7IC28.1
#=GS I7GAN0_MACFA/6-63     AC I7GAN0.1
#=GS M7BL83_CHEMY/1-45     AC M7BL83.1
#=GS G1LYY8_AILME/8-65     AC G1LYY8.1
#=GS G3T0Y3_LOXAF/8-65     AC G3T0Y3.1
#=GS W5MUW8_LEPOC/12-69    AC W5MUW8.1
#=GS G1P3E1_MYOLU/7-64     AC G1P3E1.1
#=GS H2PZ54_PANTR/8-65     AC H2PZ54.1
#=GS F6QSL1_XENTR/6-63     AC F6QSL1.1
#=GS H3D171_TETNG/10-67    AC H3D171.1
#=GS H2ZX49_LATCH/5-62     AC H2ZX49.1
#=GS G3GZE2_CRIGR/1-56     AC G3GZE2.1
#=GS R4GIB2_CHICK/6-63     AC R4GIB2.1
#=GS U3JV71_FICAL/6-63     AC U3JV71.1
#=GS V4B4S0_LOTGI/6-62     AC V4B4S0.1
#=GS H2XN51_CIOIN/6-63     AC H2XN51.1
#=GS G1S7E0_NOMLE/6-63     AC G1S7E0.1
#=GS U3J3K0_ANAPL/7-64     AC U3J3K0.1
#=GS M3XYK5_MUSPF/6-63     AC M3XYK5.1
#=GS MPDZ_RAT/6-63         AC O55164.1
#=GS MPDZ_RAT/6-63         DR PDB; 1Y76 A; 6-63;
#=GS MPDZ_RAT/6-63         DR PDB; 1Y76 C; 6-63;
#=GS J9JHV1_CANFA/8-65     AC J9JHV1.1
#=GS U3E950_CALJA/6-63     AC U3E950.1
#=GS M3ZRS6_XIPMA/6-63     AC M3ZRS6.1
#=GS E2QYC9_CANFA/8-65     AC E2QYC9.2
#=GS V8PA85_OPHHA/8-65     AC V8PA85.1
#=GS F1MAD2_RAT/8-65       AC F1MAD2.1
#=GS G3UJR8_LOXAF/7-64     AC G3UJR8.1
#=GS Q3TUR5_MOUSE/84-141   AC Q3TUR5.1
#=GS I3JAB9_ORENI/12-69    AC I3JAB9.1
#=GS E1BLF1_BOVIN/8-65     AC E1BLF1.2
#=GS G3NFP8_GASAC/6-63     AC G3NFP8.1
#=GS G1TA76_RABIT/8-65     AC G1TA76.2
#=GS E1C4T3_CHICK/8-65     AC E1C4T3.2
#=GS L8ISR9_9CETA/1-58     AC L8ISR9.1
#=GS G1KH21_ANOCA/8-65     AC G1KH21.2
#=GS H2N775_PONAB/8-65     AC H2N775.1
#=GS A2ADS8_MOUSE/8-65     AC A2ADS8.1
#=GS A2ADL9_MOUSE/8-65     AC A2ADL9.1
#=GS G3QRZ2_GORGO/10-67    AC G3QRZ2.1
#=GS G9K5R4_MUSPF/8-65     AC G9K5R4.1
#=GS B3S1C8_TRIAD/1-58     AC B3S1C8.1
#=GS H2LES7_ORYLA/9-66     AC H2LES7.1
#=GS F6S559_HORSE/10-67    AC F6S559.1
#=GS G3Q7B3_GASAC/6-63     AC G3Q7B3.1
#=GS K7G0F4_PELSI/6-63     AC K7G0F4.1
#=GS K7EG54_ORNAN/6-62     AC K7EG54.1
#=GS Q4SXL4_TETNG/1-54     AC Q4SXL4.1
#=GS S9X5I4_9CETA/1-45     AC S9X5I4.1
#=GS F5H1U9_HUMAN/6-63     AC F5H1U9.1
#=GS L5K4D3_PTEAL/21-78    AC L5K4D3.1
#=GS I3IF88_9GAMM/3-39     AC I3IF88.1
#=GS I3LVB5_PIG/6-63       AC I3LVB5.1
#=GS L5K8B1_PTEAL/7-64     AC L5K8B1.1
#=GS H2YMG7_CIOSA/6-63     AC H2YMG7.1
#=GS I3JL04_ORENI/6-63     AC I3JL04.1
#=GS M3Y832_MUSPF/8-65     AC M3Y832.1
#=GS S7ND36_MYOBR/14-71    AC S7ND36.1
#=GS Q4SAP7_TETNG/1-58     AC Q4SAP7.1
#=GS A8DZE1_DANRE/12-69    AC A8DZE1.1
#=GS U3KDB5_FICAL/8-65     AC U3KDB5.1
#=GS U3EDE3_CALJA/6-63     AC U3EDE3.1
#=GS Q3UGL9_MOUSE/8-65     AC Q3UGL9.1
#=GS G7NFZ9_MACMU/7-64     AC G7NFZ9.1
#=GS F7DF31_MONDO/8-65     AC F7DF31.2
#=GS F7IC03_CALJA/8-65     AC F7IC03.1
#=GS F6REK9_XENTR/5-62     AC F6REK9.1
#=GS B2RQR2_MOUSE/6-63     AC B2RQR2.1
#=GS F7CPH6_CALJA/8-65     AC F7CPH6.1
#=GS A5PKX9_HUMAN/8-65     AC A5PKX9.1
#=GS L9KVF6_TUPCH/8-65     AC L9KVF6.1
#=GS F6ZZY6_HORSE/8-65     AC F6ZZY6.1
#=GS W5N6R5_LEPOC/6-63     AC W5N6R5.1
#=GS H0VDJ5_CAVPO/7-64     AC H0VDJ5.1
#=GS W5PGV4_SHEEP/8-65     AC W5PGV4.1
#=GS F1QUF9_DANRE/8-65     AC F1QUF9.1
#=GS U3DBB6_CALJA/6-63     AC U3DBB6.1
#=GS G1L4U6_AILME/6-63     AC G1L4U6.1
#=GS H2YMG6_CIOSA/6-63     AC H2YMG6.1
#=GS INADL_HUMAN/8-65      AC Q8NI35.3
#=GS INADL_HUMAN/8-65      DR PDB; 1VF6 B; 10-65;
#=GS INADL_HUMAN/8-65      DR PDB; 1VF6 A; 12-65;
#=GS U6D672_NEOVI/8-65     AC U6D672.1
#=GS G1P825_MYOLU/8-65     AC G1P825.1
#=GS G3X2X5_SARHA/8-65     AC G3X2X5.1
#=GS L5ME63_MYODS/75-132   AC L5ME63.1
F6T1W3_MACMU/7-64                ....DKNRALQAAERLQTKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILSLQTSVQQLKDQVN......
A7SRG3_NEMVE/6-63                ....ETSRVVQILDGFQRKLESQGDY.DNGEDLER..IKAMLKSPLFHQLLAVQQSLRELNTQ--yh....
F7HHK2_CALJA/6-63                ....DKNRALQAAERLQTKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILSLQTSVQQLKDQVN......
F7C8K6_CALJA/6-63                ....DKNRALQAAERLQTKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILSLQTSVQQLKDQVN......
Q1LXN3_DANRE/12-69               ....ERQQVLQALERLQSKLVQREEW.THSDRLGT..LKEALQSPLFSHILTLQHSVKQLKDQLN......
H2PS57_PONAB/6-63                ....DKNRALHAAERLQTKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILSLQTSVQQLKDQVN......
F1PGB9_CANFA/6-63                ....DKNRALQAAERLQAKLRERGDV.ANEDKLNL..LKSVLQSSLFSQILNLQTSVQRLKDQVN......
G1JT17_CHICK/6-63                ....DTHRALQAVERLQAKLRDRGDI.ANEEKLNL..LKSVLQSPLFNQILNLQTSVQQLRDQVN......
M4A8E4_XIPMA/12-69               ....ERQQVLAALDRLQNRLVQREEW.SLSAALGS..LKGALQSPLFGRVLTLQHSVRQLQHQI-d.....
K9J409_DESRO/8-65                ....DKLQVLQVLDRLKMKLQEKGDT.SQNEKLCM..FYETLKSPLFNQILTLQQSIKQLKVQLS......
MPDZ_HUMAN/6-63                  ....DKNRALHAAERLQTKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILSLQTSVQQLKDQVN......
I3MPP0_SPETR/8-65                ....DKLQVLQVLDRLKMKLQDKGDT.SQNEKLSM..FYETLRSPLFNQILTLQQSIKQLKGQLS......
W5PGV1_SHEEP/8-65                ....DKLQVLQVLDRLKMKLQEKGDT.SQNEKLSL..FYETLKSPLFNQILTLQQSIKQLKGQLS......
F1N9G0_CHICK/6-63                ....DTHRALQAVERLQAKLRDRGDI.ANEEKLNL..LKSVLQSPLFNQILNLQTSVQQLRDQVN......
H3AIS3_LATCH/6-63                ....DTQRALQAVERLQAKLRDCGDA.ANEEKLSL..LKSVLQSPLFNQILNLQSSVQQLRDQM-m.....
G5AP53_HETGA/6-63                ....DKNRALQAAERLQAKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILNLQASVQQLKDQVN......
W5PWP7_SHEEP/6-63                ....DKNRAVQAAERLQAKLRERGDA.ANEDKLNL..LKSVLQSPLFSQILNLQTSIQQLKDQVN......
H2LIZ8_ORYLA/2-56                ....DTQCALEAVERLQAKLKERGET.PTQDKLSL..LKTVLQSPLFLHILSLQES---------qrnppa
F1MMT3_BOVIN/21-78               ....DKNRALQAAERLQAKLRERGDA.ANEDKLNL..LKSVLQSPLFSQILNFQTSIQQLKDQVN......
G1RY01_NOMLE/8-65                ....DKLQVLQVLDRLKMKLQEKGDM.SQNEKLSM..FYETLKSPLFNQILTLQQSIKQLKGQLN......
D3ZKZ2_RAT/8-65                  ....EKMQVLQVLDRLRGKLQEKGDT.TQNEKLSA..FYETLKSPLFNQILTLQQSIKQLKGQLS......
W5LF57_ASTMX/12-69               ....ERQQVLQALERLQSKLVQREEW.THSERLGA..LKEALQSPLLGHILTLQHSVKQLRDQLN......
W5MUV5_LEPOC/12-69               ....ERQQVLQALERLQSKLKDRDDR.THSERLGA..LRDALRSPLLGHILTLQHSIKQLKEQLN......
INADL_MOUSE/8-65                 ....EKMQVLQVLDRLRGKLQEKGDT.TQNEKLSA..FYETLKSPLFNQILTLQQSIKQLKGQLS......
#=GR INADL_MOUSE/8-65      SS    ....--CHHHHHHHHHHHHHHHHT--.TTHHHHHH..HHHHHH-HHHHHHHHHHHH-TTB-S-CT......
G3TKC2_LOXAF/6-63                ....DKNRALRAAERLQAKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILSLQTSVQNLKEQV-d.....
H2LHB5_ORYLA/6-63                ....DTQRALQAVERLQAKLKERGEV.PTEEKLSL..LKSVLQSPLFHQILALQKSVQHLKEQVN......
K7DKU2_PANTR/8-65                ....DKLQVLQVLDRLKMKLQEKGDT.SQNEKLSM..FYETLKSPLFNQILTLQQSIKQLKGQLN......
K1R7T1_CRAGI/11-67               ...g-TEQAVEYVEHLQTRLWDQGDH.SMDDDLTS..LLAMMESPLFRQILNLQESLQELKQ---vt....
J3S4I8_CROAD/8-65                ....NKQQILRILEHLLMKLHEKGDT.SQSDNLVF..LYNTLKNPLFNHMLTLQQSIKQLKEQL-r.....
F7I9N8_CALJA/8-65                ....DKLQVLQVLDRLKMKLQEKGDT.SQNEKLSV..FYETLKSPLFNQILTLQQSIKQLKGQLN......
V9K7M9_CALMI/6-63                ....DTPRALQALERLQAKLRERGDV.VNEEKLNL..LRSVLQSPLFNQILNLQSSVQQLKDQVN......
F7FYD6_CALJA/6-63                ....DKNRALQAAERLQTKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILSLQTSVQQLKDQVN......
F1PGC1_CANFA/6-63                ....DKNRALQAAERLQAKLRERGDV.ANEDKLNL..LKSVLQSSLFSQILNLQTSVQRLKDQVN......
G1NGL1_MELGA/8-65                ....DKQQVLQIIDRLQAKLREKRDV.QHNENLTV..LRNTLRSPLFNQILTLQQSIKQLKDQLN......
M3WF73_FELCA/2-59                ....DKNRALQAAERLQAKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILNLQTSVQQLKDQVN......
K7FFA6_PELSI/8-65                ....DKQQVLQILDRLQMKLRERGET.FENEKLTV..LCSTLRSPLFNQILTLQQSIKQLKEQL-d.....
T1INI3_STRMM/1-58                ....-TRQALSLLERIQRQLRASDSIqPVSQDLSK..LISLLESPVFRNILTIQDSLHELRRQI-h.....
H2RX16_TAKRU/10-67               ....DTQRALQAVERLQAKLKERGEV.PTEEKLNL..LRSVLQSPLFHQILALQKSVQHLRDQ--th....
D3YUX2_MOUSE/6-63                ....DKNRALQAAERLQSKLKERGDV.ANEDKLSL..LKSVLQSPLFSQILNLQTSLQQLKDQVN......
M4ACC1_XIPMA/6-56                ....DAQCALEAVERLQAKLRERGEA.PTQEKLSV..LKTVLQSPLFLHILSLQQA---------qp....
I3JQI1_ORENI/5-57                ....DTQCALAAVERLQAKLKERGEA.PTQEKLSL..LKTVLQSPLFLHILSLQQAQQ-------kp....
K7E7G9_ORNAN/8-65                ....DKLQILQVLDRLQAKLQERGDV.SQEEKLSL..FGDALRSPLFDQILTLQRSIRQLKEQL-g.....
G7PSC6_MACFA/7-64                ....DKNRALQAAERLQTKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILSLQTSVQQLKDQVN......
H2YMG8_CIOSA/6-63                .ele---KAAVVLKRLQNQLKRQGDY.SHDAELDA..MKSLMESPLFKKMVQLQASIQQLKK---eas...
G3S205_GORGO/6-63                ....DKNRALHAAQRLQTKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILSLQTSVQQLKDQVN......
S9XL16_9CETA/7-64                ....DKNRALQAAERLQAKLRERGDV.ANEDRLNL..LKSVLQSPLFSQILNLQTSVQQLKDQVN......
H3CK11_TETNG/47-103              ..vt---SVLGALERLQTKLVQREEW.SHSGAVGT..LRQTLQSPLLSHILTLQQSIRQLRNQL-t.....
W5PWQ2_SHEEP/6-63                ....DKNRAVQAAERLQAKLRERGDA.ANEDKLNL..LKSVLQSPLFSQILNLQTSIQQLKDQVN......
G7MHB0_MACMU/8-65                ....DKLQVLQVLDRLKMKLQEKGDT.SQNEKLSV..FYETLKSPLFNQILTLQQSIKQLKGQLN......
T2M9I3_HYDVU/1-57                ...t--SQVCDILERFRHNLKSEGNY.EHDKDLAD..MISMLDSPLFKQIVTVHDSLNELNK---kfq...
A2ADS6_MOUSE/8-65                ....EKMQVLQVLDRLRGKLQEKGDT.TQNEKLSA..FYETLKSPLFNQILTLQQSIKQLKGQLS......
H9G1B4_MACMU/6-63                ....DKNRALQAAERLQTKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILSLQTSVQQLKDQVN......
G1SLR4_RABIT/6-63                ....DKNRALQAAERLQAKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILNLQTSMQQLKDQVN......
F6RHB2_MONDO/6-63                ....DTSRALQAAERLQVKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILNLQTSVQQLKDQVN......
W4YY52_STRPU/190-247             ....DTQRAVSVLQGLQGRLVAAGEP.ELGEQFAS..MIDLLASPSFRHLLNLQQSVRELKHHI-d.....
MPDZ_MOUSE/6-63                  ....DKNRALQAAERLQSKLKERGDV.ANEDKLSL..LKSVLQSPLFSQILNLQTSLQQLKDQVN......
H0WLW5_OTOGA/8-65                ....DKLQVLQVLDRLKGKLQEKGDT.SQNEKLSL..FYETLRSPLFNQILTLQQSIKQLKGQLS......
D2HP61_AILME/1-58                ....DKLQVLQVLDRLKMKLQEKGDT.SQSEKLSL..FYETLRSPLFNQILTLQQSIKQLKGQLS......
H2R430_PANTR/6-63                ....DKNRALHAAERLQTKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILSLQTSVQQLKDQVN......
W5UKL3_ICTPU/12-69               ....EQQQVLQAVERLQSKLAQREEW.THSERLGA..LKEALQSPLLGRILTLQHSLKQLKDQLN......
G3WB42_SARHA/6-63                ....DTSRALQAAERLQAKLRERGDI.ANEDKLSL..LKSVLQSPLFSQILNLQTSVQQLKDQVN......
G5BSM7_HETGA/8-65                ....DKLQVLQVLQRLRAKLQDRGDT.SQHSTLSA..FCDTLQSPLFTQILALQKSLRQLKGQLS......
H0WTI1_OTOGA/6-63                ....DKNRALQAAERLQTKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILNLQTSVQQLKDQVN......
V8NUY1_OPHHA/15-72               ...d-IHRALQAVERLQAKLRERGDS.ANEEKLSL..LKSVLQSPLFNQILNLQASLPQSRDQVN......
D2H2X4_AILME/6-63                ....DKNRALQAAERLQAKLRERGDV.ANEDKLNL..LKSVLQSPLFSQILNLQTSVQQLKDQVN......
G1KL12_ANOCA/6-63                ....DTHRALQAVERLQVKLRERGDT.SNEEKLSL..LKSVLQSPLFNQILNLQICLPQSRDQVN......
M3W3U3_FELCA/8-65                ....DKLQVLQVLDRLKMKLQEKGDT.SQNEKLSL..FYETLKSPLFNQILTLQQSIKQLRGQLS......
H2N774_PONAB/8-65                ....DKLQVLQVLDRLKMKLQEKGDT.SQNEKLSM..FYETLKSPLFNQILTLQQSIKQLKGQLN......
W5N6S3_LEPOC/6-63                ....DTQRALQAVERLQAKLKERGDV.LTEEKLNM..LKTVLQSPLFQQILTLQTSVQQLKEQV-g.....
F6T1X2_MACMU/7-64                ....DKNRALQAAERLQTKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILSLQTSVQQLKDQVN......
U3I527_ANAPL/8-65                ....DKQQVLQILDRLQAKLREKRDA.QHNENLTV..LRNTLRSPLFNQILTLQQSIKQLKEQLN......
G3PTR0_GASAC/11-62               ....DAQLALEAVERLQAKLKERGEA.PTQEKLSL..LKTVLQSPLFHNILSLQQA---------qrk...
L8Y8X5_TUPCH/7-63                ....DKNRALQAAERLQAKLRERGDA.ANEDKLSL..LKSVLQSPLFSQILNLQTSVQQLKDQ--g.....
F7IC28_CALJA/8-65                ....DKLQVLQVLDRLKMKLQEKGDT.SQNEKLSV..FYETLKSPLFNQILTLQQSIKQLKGQLN......
I7GAN0_MACFA/6-63                ....DKNRALQAAERLQTKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILSLQTSVQQLKDQVN......
M7BL83_CHEMY/1-45                ...m--------------KLRERGET.SQNENLTI..LCNTLRSPLFNQILTLQQSIKQLKEQLN......
G1LYY8_AILME/8-65                ....DKLQVLQVLDRLKMKLQEKGDT.SQSEKLSL..FYETLRSPLFNQILTLQQSIKQLKGQLS......
G3T0Y3_LOXAF/8-65                ....DKIQVLQVLERLKMKLQEKGDT.SQNEKLST..FYETLRSPLFNQILTLQQSIKQLKGQLS......
W5MUW8_LEPOC/12-69               ....ERQQVLQALERLQSKLKDRDDR.THSERLGA..LRDALRSPLLGHILTLQHSIKQLKEQLN......
G1P3E1_MYOLU/7-64                ....DKNRALQAAERLQAKLRERGDV.ANEDKLNL..LKSVLQSPLFSQILNLQTSVQQLKDQVN......
H2PZ54_PANTR/8-65                ....DKLQVLQVLDRLKMKLQEKGDT.SQNEKLSM..FYETLKSPLFNQILTLQQSIKQLKGQLN......
F6QSL1_XENTR/6-63                ....DTHRALQAVERLQVKVRERGDI.ANEEKLCL..LKSVLQSPLFNQILSLQTSLQHLREQVN......
H3D171_TETNG/10-67               ....DTQRALQAVERLQARLKERGEV.PTEEKLSL..LRSVLQSPLFHQILALQKSVQHLRDQVN......
H2ZX49_LATCH/5-62                ....DKQHVLQAIDRLKTKLREKGDT.SQTEKLNI..LHDTVQSPLFNQILTIQHSIKQLKEQVS......
G3GZE2_CRIGR/1-56                ....--MQVLQVLDRLRMKLQEKGDT.TQNEKLSA..FYEMLKSPLFNQILTLQQSIKQLKGQLS......
R4GIB2_CHICK/6-63                ....DTHRALQAVERLQAKLRDRGDI.ANEEKLNL..LKSVLQSPLFNQILNLQTSVQQLRDQVN......
U3JV71_FICAL/6-63                ....DTHRALQAMERLQAKLRDRGDI.ANEEKLSL..LKSVLQSPLFNQILSLQTSVQQLRDQVN......
V4B4S0_LOTGI/6-62                ...d-CEQAADIVDRLKASLQEQGDF.HKDDELSS..ILCMLKSPLFHQLLTLQKSLHKLKE---vs....
H2XN51_CIOIN/6-63                elek----AALIIKRIQNQLKRQGDY.SNDAELEA..MKSLMESPLFKKMAQLQASIQQLKKEV-v.....
G1S7E0_NOMLE/6-63                ....DKNRALHAAERLQTKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILSLQTSVQQLKDQG-n.....
U3J3K0_ANAPL/7-64                ....DTHRALQAVERLQAKLRDRGDI.ANEEKLSL..LKSVLQSPLFNQILNLQTSVQQLRDQV-g.....
M3XYK5_MUSPF/6-63                ....DKNRALQAAERLQAKLRERGDG.ANEDKLNL..LKSVLQSPLFSQILNLQASVQQLKDQVN......
MPDZ_RAT/6-63                    ....DKNRALQAAERLQSKLKERGDV.ANEDKLSL..LKSVLQSPLFSQILSLQTSLQQLKDQVN......
#=GR MPDZ_RAT/6-63         SS    ....HHHHHHHHHHHHHHHHHHHHHT.-TTTHHHH..HHHHHHHH-HHHHHHHHHHHHHHHHHHH......
J9JHV1_CANFA/8-65                ....DKLQVLQVLDRLKMKLQEKGDT.SQNEKLSL..FYETLQSPLFNQILTLQQSIKQLKGQLS......
U3E950_CALJA/6-63                ....DKNRALQAAERLQTKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILSLQTSVQQLKDQVN......
M3ZRS6_XIPMA/6-63                ....DTQRALQAVERLQAKLKERGEV.PTEEKLSL..LRSVLQSPLFHQILALQKSVQHLRDQ--gs....
E2QYC9_CANFA/8-65                ....DKLQVLQVLDRLKMKLQEKGDT.SQNEKLSL..FYETLQSPLFNQILTLQQSIKQLKGQLS......
V8PA85_OPHHA/8-65                ....DKQQILKILERLLMKLHEKGDT.SHSDNLAF..LYNTLKNPLFNHVLTLQQSIKQLKEQVS......
F1MAD2_RAT/8-65                  ....EKMQVLQVLDRLRGKLQEKGDT.TQNEKLSA..FYETLKSPLFNQILTLQQSIKQLKGQLS......
G3UJR8_LOXAF/7-64                ....DKNRALRAAERLQAKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILSLQTSVQNLKEQV-d.....
Q3TUR5_MOUSE/84-141              ....DKNRALQAAERLQSKLKERGDV.ANEDKLSL..LKSVLQSPLFSQILNLQTSLQQLKDQV-g.....
I3JAB9_ORENI/12-69               ....ERQQVLAALERLQAKLVQREEW.THSDTLGN..LRETLQSPLFNHILTLQHSIKQLRSQLS......
E1BLF1_BOVIN/8-65                ....DKLQVLQVLDRLKMKLQEKGDT.SQNEKLSL..FYETLKSPLFNQILTLQQSIKQLKGQLS......
G3NFP8_GASAC/6-63                ....ERQQVVGALERLRAKLVQREDW.THSETLGN..LSETLQSPLFSHILTLQHSIQQLRSQLN......
G1TA76_RABIT/8-65                ....DKLQVLQVLDRLKMKLQEKGDT.SQNEKLSV..FCETLRSPLFNQILTLQQSIKQLKGQLS......
E1C4T3_CHICK/8-65                ....DKQQVLQIIDRLQAKLREKRDV.QHNENLSV..LRNTLRSPLFNQILTLQQSIKQLKDQLN......
L8ISR9_9CETA/1-58                ....DKLQVLQVLDRLKMKLQEKGDT.SQNEKLSL..FYETLKSPLFNQILTLQQSIKQLKGQLS......
G1KH21_ANOCA/8-65                ....DKQQVLQILEHLLMKLHERGDT.SHSENLAF..LYNTLKNPLFNHMLTLQQSIKQLKEQL-t.....
H2N775_PONAB/8-65                ....DKLQVLQVLDRLKMKLQEKGDT.SQNEKLSM..FYETLKSPLFNQILTLQQSIKQLKGQLN......
A2ADS8_MOUSE/8-65                ....EKMQVLQVLDRLRGKLQEKGDT.TQNEKLSA..FYETLKSPLFNQILTLQQSIKQLKGQLS......
A2ADL9_MOUSE/8-65                ....EKMQVLQVLDRLRGKLQEKGDT.TQNEKLSA..FYETLKSPLFNQILTLQQSIKQLKGQLS......
G3QRZ2_GORGO/10-67               ....DKNRALHAAQRLQTKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILSLQTSVQQLKDQVN......
G9K5R4_MUSPF/8-65                ....DKLQVLQVLDRLKMKLQEKGDT.SQNEKLSL..FYETLKSPLFNQILTLQQSIRQLKGQLS......
B3S1C8_TRIAD/1-58                ....DTSRALAVLSKFHNKLKTDGFE.SHAQNLSK..VRDMLQHPVFGHLLNMQSSMGDM-----iekvc.
H2LES7_ORYLA/9-66                ....ERQQVLGALERLRAKLVQREEW.THSDRLAN..LQVALQSPLFSHILTLQHSIKQLRDQLS......
F6S559_HORSE/10-67               ....DKNRALQAAERLQAKLRERGDV.ANEDKLNL..LKSVLQSPLFSQILNLQTSVQQLKEQVN......
G3Q7B3_GASAC/6-63                ....DTQRALQAVERLQAKLKERGEV.PTEEKLSL..LKSVLQSPLFHQILALQKSVQHLRDQV-k.....
K7G0F4_PELSI/6-63                ....DTHRALQAVERLHMKLRERGDI.ANEEKLSL..LKSVLQSPLFSQILNLQTSVHQLKDQVN......
K7EG54_ORNAN/6-62                ....DTHRALQAVERLQTKLRDRGDI.ANEEKLSL..LKSVLQSPLFSQILNLQSSFQLLRDQ--p.....
Q4SXL4_TETNG/1-54                ....----VLGALERLQTKLVQREEW.SHSGAVGT..LRQTLQSPLLSHILTLQQSIRQLRNQL-t.....
S9X5I4_9CETA/1-45                ...m--------------KLQEKGDT.SQNEKLSM..FYETLKSPLFNQILTLQQSIKQLKGQLS......
F5H1U9_HUMAN/6-63                ....DKNRALHAAERLQTKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILSLQTSVQQLKDQVN......
L5K4D3_PTEAL/21-78               ....DKLQVLQVLDRLKAKLQEKGDT.SQNEKISM..FYETLKSPLFNQILTLQQSIKQLKGQLS......
I3IF88_9GAMM/3-39                .ltk----------------------.----KLSLhmLKKMLYSTLFSQHLALDTVPAMLKDQLS......
I3LVB5_PIG/6-63                  ....DKNRALQAAERLQAKLRERGDV.ANEDKLNL..LKSVLQSPLFSQILNLQTSVQQLKDQV-g.....
L5K8B1_PTEAL/7-64                ....DKTRALQAAERLQAKLRERGDV.ANEDKLNL..LKSVLQSPLFSQILNLQTSVQQLKDQVN......
H2YMG7_CIOSA/6-63                .ele---KAAVVLKRLQNQLKRQGDY.SHDAELDA..MKSLMESPLFKKMVQLQASIQQLKK---eas...
I3JL04_ORENI/6-63                ....DTQRALQAVERLQAKLKERGEV.PTEEKLSL..LKSVLQSPLFHQILALQKSVQHLRDQVN......
M3Y832_MUSPF/8-65                ....DKLQVLQVLDRLKMKLQEKGDT.SQNEKLSL..FYETLKSPLFNQILTLQQSIRQLKGQLS......
S7ND36_MYOBR/14-71               ...h-KLQVLQILDRLKVKLQEKGDT.SQIEKLSM..FYGTLESPLFNQILTLQQSIKQLKGQLS......
Q4SAP7_TETNG/1-58                ....DTQRALQAVERLQARLKERGEV.PTEEKLSL..LRSVLQSPLFHQILALQKSVQHLRDQVN......
A8DZE1_DANRE/12-69               ....ERQQVLQALERLQSKLVQREEW.THSDRLGT..LKEALQSPLFSHILTLQHSVKQLKDQV-m.....
U3KDB5_FICAL/8-65                ....DKQQVLQILDRLQAKLQERRDS.QHQENLAV..LRNTLRSPLFNQILTLQQSIKQLKEQLN......
U3EDE3_CALJA/6-63                ....DKNRALQAAERLQTKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILSLQTSVQQLKDQVN......
Q3UGL9_MOUSE/8-65                ....EKMQVLQVLDRLRGKLQEKGDT.TQNEKLSA..FYETLKSPLFNQILTLQQSIKQLKGQLS......
G7NFZ9_MACMU/7-64                ....DKNRALQAAERLQTKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILSLQTSVQQLKDQVN......
F7DF31_MONDO/8-65                ...n-KLQILQVLERLQMKLQDRGDT.SQNEKLAL..FCETLKSPLFNQILTIQQSIRQLKGQLS......
F7IC03_CALJA/8-65                ....DKLQVLQVLDRLKMKLQEKGDT.SQNEKLSV..FYETLKSPLFNQILTLQQSIKQLKGQLN......
F6REK9_XENTR/5-62                ....DKAQVLLIAERLQKKLKDKGDL.SHHEKMCI..LRDTLKSPLFNQILTVQQSIKQLKEQVS......
B2RQR2_MOUSE/6-63                ....DKNRALQAAERLQSKLKERGDV.ANEDKLSL..LKSVLQSPLFSQILNLQTSLQQLKDQVN......
F7CPH6_CALJA/8-65                ....DKNRALQAAERLQTKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILSLQTSVQQLKDQVN......
A5PKX9_HUMAN/8-65                ....DKLQVLQVLDRLKMKLQEKGDT.SQNEKLSM..FYETLKSPLFNQILTLQQSIKQLKGQLN......
L9KVF6_TUPCH/8-65                ....DKLQVLQVLDRLKAKLQEKGDV.SQNEKLSM..FYETLRSPLFNQILTLQQSIKQLKGQLS......
F6ZZY6_HORSE/8-65                ....DKLQVLQVLDRLKMKLQEKGDA.SQNEKLSV..FYETLKSPLFNQILTLQQSIKQLKGQLS......
W5N6R5_LEPOC/6-63                ....DTQRALQAVERLQAKLKERGDV.LTEEKLNM..LKTVLQSPLFQQILTLQTSVQQLKEQV-d.....
H0VDJ5_CAVPO/7-64                ....DKNRALQAAERLQAKLRERGDI.ANEDKLSL..LKSVLQSPLFSQILNLQASVQQLKDQVS......
W5PGV4_SHEEP/8-65                ....DKLQVLQVLDRLKMKLQEKGDT.SQNEKLSL..FYETLKSPLFNQILTLQQSIKQLKGQLS......
F1QUF9_DANRE/8-65                ....ERQQVLQALERLQSKLVQREEW.THSDRLGT..LKEALQSPLFSHILTLQHSVKQLKDQLN......
U3DBB6_CALJA/6-63                ....DKNRALQAAERLQTKLRERGDV.ANEDKLSL..LKSVLQSPLFSQILSLQTSVQQLKDQVN......
G1L4U6_AILME/6-63                ....DKNRALQAAERLQAKLRERGDV.ANEDKLNL..LKSVLQSPLFSQILNLQTSVQQLKDQVN......
H2YMG6_CIOSA/6-63                .ele---KAAVVLKRLQNQLKRQGDY.SHDAELDA..MKSLMESPLFKKMVQLQASIQQLKK---eas...
INADL_HUMAN/8-65                 ....DKLQVLQVLDRLKMKLQEKGDT.SQNEKLSM..FYETLKSPLFNQILTLQQSIKQLKGQLN......
#=GR INADL_HUMAN/8-65      SS    ....XXXHHHHHHHHHHHHHHHCT--.TTHHHHHH..HHHHHH-HHHHHHHHHHHHHHHHHHHHH......
U6D672_NEOVI/8-65                ....DKLQVLQVLDRLKMKLQEKGDT.SQNEKLSL..FYETLKSPLFNQILTLQQSIRQLKGQLS......
G1P825_MYOLU/8-65                ....DKLQVLPILDRLKVKLQEKGDT.SQIEKLSM..FYETLKSPLFNQILTLQQSIKQLKGQLS......
G3X2X5_SARHA/8-65                ...n-KLQILQVLERLQMKLHERGDT.SQHERLVL..FSETLKSPLFNQILTIQQSIKQLKGQLS......
L5ME63_MYODS/75-132              ....DKNRALQAAERLQAKLRERGDV.ANEDKLNL..LKSVLQSPLFSQILNLQTSVQQLKDQVN......
#=GC SS_cons                     ....HHCHHHHHHHHHHHHHHHHTHT.TTHHHHHH..HHHHHHHHHHHHHHHHHHHHHHHHHHHH......
#=GC seq_cons                    ....DKppsLQslERLQsKL+ERGDs.upp-KLSl..L+ssLpSPLFsQILoLQpSlpQLKcQls......
//
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