GenomeNet

Database: Pfam
Entry: LAP2alpha
LinkDB: LAP2alpha
Original site: LAP2alpha 
#=GF ID   LAP2alpha
#=GF AC   PF11560.6
#=GF DE   Lamina-associated polypeptide 2 alpha
#=GF AU   Pollington J
#=GF SE   pdb_2v0x
#=GF GA   25.00 25.00;
#=GF TC   25.30 25.00;
#=GF NC   24.90 24.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   17562312
#=GF RT   Structural basis for dimerization of LAP2alpha, a component of
#=GF RT   the nuclear lamina. 
#=GF RA   Bradley CM, Jones S, Huang Y, Suzuki Y, Kvaratskhelia M, Hickman
#=GF RA   AB, Craigie R, Dyda F; 
#=GF RL   Structure. 2007;15:643-653.
#=GF DR   INTERPRO; IPR021623;
#=GF CC   LAPs are components of the nuclear lamina which supports the
#=GF CC   nuclear envelope.LAP2alpha is a non-membrane-associated member
#=GF CC   of the LAP family which is unique. This family of proteins is
#=GF CC   the C terminal domain of LAP2alpha which consists of residues
#=GF CC   459-693 and constitutes a dimeric structure with an antiparallel
#=GF CC   coiled coil. LAP2alpha is involved in cell-cycle regulation and
#=GF CC   chromatin organisation and preferentially binds to lamin A/C
#=GF CC   [1].
#=GF SQ   33
#=GS G3TD04_LOXAF/460-692      AC G3TD04.1
#=GS W5P749_SHEEP/349-501      AC W5P749.1
#=GS H0X6F2_OTOGA/458-690      AC H0X6F2.1
#=GS M7B108_CHEMY/7-137        AC M7B108.1
#=GS M7BJC6_CHEMY/10-147       AC M7BJC6.1
#=GS M7BUZ7_CHEMY/13-222       AC M7BUZ7.1
#=GS F7HAU0_MACMU/462-694      AC F7HAU0.1
#=GS M7BXM2_CHEMY/199-370      AC M7BXM2.1
#=GS M7B3G0_CHEMY/49-254       AC M7B3G0.1
#=GS F6YF13_MACMU/345-498      AC F6YF13.1
#=GS L5JN49_PTEAL/281-434      AC L5JN49.1
#=GS G1LW26_AILME/460-692      AC G1LW26.1
#=GS G3QLH5_GORGO/461-693      AC G3QLH5.1
#=GS M7APM7_CHEMY/12-213       AC M7APM7.1
#=GS M7BZD3_CHEMY/118-344      AC M7BZD3.1
#=GS A0A091E7L8_FUKDA/567-787  AC A0A091E7L8.1
#=GS G7PJ42_MACFA/370-602      AC G7PJ42.1
#=GS G5B2K7_HETGA/366-597      AC G5B2K7.1
#=GS M7AVU9_CHEMY/106-318      AC M7AVU9.1
#=GS L9LCW4_TUPCH/532-764      AC L9LCW4.1
#=GS LAP2A_MOUSE/459-692       AC Q61033.4
#=GS LAP2A_MOUSE/459-692       DR PDB; 2V0X A; 465-685;
#=GS LAP2A_MOUSE/459-692       DR PDB; 2V0X B; 465-689;
#=GS M7BLD8_CHEMY/1427-1527    AC M7BLD8.1
#=GS Q8VCL4_MOUSE/343-497      AC Q8VCL4.1
#=GS LAP2A_HUMAN/461-693       AC P42166.2
#=GS H0VJK1_CAVPO/323-555      AC H0VJK1.1
#=GS S9Y6N0_9CETA/343-575      AC S9Y6N0.1
#=GS M7B7Z8_CHEMY/12-161       AC M7B7Z8.1
#=GS L5KIK6_PTEAL/460-688      AC L5KIK6.1
#=GS F6YNY7_CALJA/461-690      AC F6YNY7.1
#=GS G3I2N4_CRIGR/90-318       AC G3I2N4.1
#=GS S9XDH7_9CETA/281-434      AC S9XDH7.1
#=GS I3MD17_ICTTR/459-691      AC I3MD17.1
#=GS M7AIL8_CHEMY/3187-3415    AC M7AIL8.1
G3TD04_LOXAF/460-692                 ...................................................................AKTVVSNSLTTLGIEMSK.QSQHDKIDDYEL...SFPLHESILKVIEEEWQQIDRQRP...S...LAC....KYPVSSREAPRILSVPKVDDEILGFLSEGSPPAGIQAASSEA.C.D.KQLDLALCRTYEAAASALQIATHAAFVVRAMQADISQA.AQILSSDPT.QMH.QAL.R.ILSK.TY.DAASYLCEAAFDEVKMAAHTMGSSSVGRRYLWLKDCKINPASKNKLAVTPFKGGTLFGGEVCKIIKKRGNK.........
W5P749_SHEEP/349-501                 .....................................................gpivealehsrrgg------------------.------------...------------------------...-...---....-----------------------------------TTSPLDS.T.S.KEMEVMGCRFYHAASIAARAASYMAYMTQ-YQRKLWED.MEDLVHDPEfDRG.KAR.C.IISD.GM.DAGLWQLCTTRDIMDSVVRVMAMAIDYRRQAWLRLTSLTKKTQEKISHLPFDGTCLFGQDVNAVVA-----eens.....
H0X6F2_OTOGA/458-690                 ...................................................................AKSVVSHSLTTLGIEMSK.ESQYDKIHASEP...SFPLHESILKVIEEEWQQIDRQLP...S...LAC....KYPISSGEATRILSVPKVDDEILGFISEATPPASIQAATTES.C.D.KQLDLALCRAYEAAASALQIATHTAFVAKAMQADISQA.ARILSSDPS.RMQ.QAL.G.ILSK.TY.DAASYICDAAFDEVKISAHTMGNSTVGRRHLWLKECKLNSASKNKLAVTSFKGGTLFGGEVYKVIKKRGNK.........
M7B108_CHEMY/7-137                   ..........................................hpqlnsllveaanrhskqpqfwstp------------------.------------...------------------------...-...---....---------------------------------------QDK.E.H.KHLDLFGLKAYLSATLQFQVANYSALLAKYNFDNYSKL.REFLEVLPEeKCP.QFT.A.IMNE.GQ.LIACTALQALMDIVDTAARTTATAVVIRRVSWIQ-------------------------------------yerapt...
M7BJC6_CHEMY/10-147                  ptpknkysqrldsfgrrlyyplsfqlrvanhqallgryefslwgslpkfedplqehnkkefkalvee------------------.------------...------------------------...-...---....------------------------------------------.-.-.--------------------------------------.---------.---.---.-.----.GT.VAARASLQAALDVADMAACSMASVVSMRRALWLLLSGLSSGAQAALQDLPFDSKALFAEQM----------vtklhgmk.
M7BUZ7_CHEMY/13-222                  ............................................................sslapgr------------------.-----------V...ALPLHKGVAKISNALWQTLASLAPiskR...AEC....KYFVSAMGHEYLYTHPAPNSLVVKLVNHREWQRQPDPTSKNK.D.S.RRLDSFGRKIYLSSSFQLWVANHQALLGRYEFNLWGSL.RKFEDSLQK.HER.KEF.K.VLVE.EGsAAARATLQAAADAADMAGWSMASAVSLRRALWLLLSGLSSEAQTSLQDLPFDVKALFAE------------qtdtklh..
F7HAU0_MACMU/462-694                 ...................................................................AKTVVSHSLTTLGLEVSK.QSQHDKIDASEL...SFPFHESILKVIEEEWQQVDRQLP...S...LAC....RYPVSSKEATRLLSVPKVDDEILGFISEATPPAGIQATSTES.C.D.KQLDLALCRAYEAAASALQIATHTAFVAKAMQADISQA.AQILSSDPS.RTH.QAL.G.ILSK.TY.DAASYICEAAFDEVKMAAHTMGNSTVGRRYLWLKDCKINLASKSKLASTPFKGGTLFGGEVCKVIKKRGNK.........
M7BXM2_CHEMY/199-370                 ....................................rkyfapskgyeflfchpspcslvvsainere------------------.------------...------------------------...-...---....-------------------------------RHGQQAPAPEA.ReA.KRLDLFGRKVYSSAGLQLRIANQQAILNRHNFNSWAAV.GKFKDNLPQ.GSQ.QEF.MtLVDE.GK.AVAKTSLQASLDSADLVARTIASGVVMRRSAWLQESGLPPEVQNTLQDLPFKGSGLFSD------------qtdtrlh..
M7B3G0_CHEMY/49-254                  ...srvalplirtiqtttriiwqtpvsipptakgvqqkyfvplkgydylfthpqpcslvvasvneke------------------.------------...------------------------...-...---....-------------------------------RHGQQAPAPKS.K.DaKCLDLCGCKVYSSAGLQLRIANQQALLSRYNFNSWNSM.LKFKELVPP.KSR.EEF.A.ALAEeGK.TVAQTSLQASLDAADSAAHTLSSGITVRRIFWLQASGLPPELQQTLQDLPFDGACLFSE------------ktnsrlqs.
F6YF13_MACMU/345-498                 ......................................................egpivealehskr------------------.------------...------------------------...-...---....---------------------------------GNTTSPLDS.T.S.KEMEVMGCRFYHAASIAARAASYMAYMTQ-YQRKLWED.MEDLVHDPEfDRG.KAR.C.IISD.GM.DAGLWQLCTTRDIMDSVVRVMAMAIDYRRQAWLRLTSLTKKTQEKISHLPFDGTSLFGQDVKAVVA-----eens.....
L5JN49_PTEAL/281-434                 ......................................................egpivealehskr------------------.------------...------------------------...-...---....---------------------------------GSTTSPLDS.T.S.KEMEVMGCRFYHAASIAARAASYMAYMTQ-YQRKLWED.MEDLVHDPEfDRG.KAR.C.IISD.GM.DAGLWQLCTTRDIMDSVVRVMAMAVDYRRQAWLRLTSLTKKTQEKISHLPFDGTSLFGQDVNAVVA-----eens.....
G1LW26_AILME/460-692                 ...................................................................AKTVVSHSLTTLGIEMSK.QSQHEKIDASEL...SFPFHESILKVIEEEWQQIDRQLP...S...LAC....KYPISSREATQILSVPKVDDEILEFISEATPPVGIQAASTES.C.D.KQLDLVLCRTYEAAASALQIATHTAFVVKALQADISQV.AQILSSDPS.HMH.QAL.G.ILSK.TY.DAASFLCEAAFDEVKMAAHSMGSSTLGRRYLWLKDCKINPASKNKLVVTPFKGGTLFGGEVCKVTKKRGNK.........
G3QLH5_GORGO/461-693                 ...................................................................AKTVVSHSLTTLGLEVAK.QSQHDKIDASEL...SFPFHESILKVIEEEWQQVDRQLP...S...LAC....KYPVSSREATQILSVPKVDDEILGFISEATPLAGIQAASTES.C.N.QQLDLALCRAYEAAASALQIATHTAFVAKAMQADISQA.AQILSSDPS.RTH.QAL.G.ILSK.TY.DAASYICEAAFDEVKMAAHTMGNSTVGRRYLWLKDCKINLASKNKLASTPFKGGTLFGGEVCKVIKKRGNK.........
M7APM7_CHEMY/12-213                  rialpliktiqsnyktiwqtpassapmakgverkyfapskgyvflfchpspcslvvsavderewhgq------------------.------------...------------------------...-...---....-----------------------------------QATAPKAkE.A.KCLDLFGRKVYSSGGLQLRIANHQATLNRHNFSSWAAV.GKFKDNLPQ.GSQ.QQFtA.LVDK.GK.TVAKTSLQASLDSADMVARTVTSGVVMRCSVWLQESGLPPKVQNTLQDLPFKGSGLFSD------------qtdmr....
M7BZD3_CHEMY/118-344                 ..................................................vafnlglqaeeleepsd------------------.-SLFDILCASAParvALLIHEGVSKITNALWQTPSSLAPiskR...AEC....KYFMPTKGHEYLYSHPAPNSLVVQVINHKERQGQLRATPKNK.D.S.RWLDLFGRKIYLSSSLQLRVANHQALLGQY-DFNMWQAmAKFEGSLPE.ASK.KEF.RaILNE.GT.NAARAALQVASDVADAAACTMASAISMQQASWLLLSGLSTEAQQSMQDLCFD-------------------gwataasg.
A0A091E7L8_FUKDA/567-787             ...................................................................AKAVISHSLTALGIEMSN.QSQHDKIEASEL...SFPFHESILKVIEEEWQQIDRQLP...S...LAC....KYPVSAREATRILSVPKVDDEILGFISEATPPAGIQPASAES.C.D.KHLDLALCRTYETTASALQIATHSAFVAKAMQADISQA.AQILSSDPS.RTP.QVL.E.ILSK.TY.DAASFLCEAAFDEVRVSARTMASSTVGRRHLWLKDCKISPASKNKLTVAPFKDS-----------------kielk....
G7PJ42_MACFA/370-602                 ...................................................................AKTVVSHSLTTLGLEVSK.QSQHDKIDASEL...SFPFHESILKVIEEEWQQVDRQLP...S...LAC....RYPVSSKEATRLLSVPKVDDEILGFISEATPPAGIQATSTES.C.D.KQLDLALCRAYEAAASALQIATHTAFVAKAMQADISQA.AQILSSDPS.RTH.QAL.G.ILSK.TY.DAASYICEAAFDEVKMAAHTMGNSTVGRRYLWLKDCKINLASKSKLASTPFKGGTLFGGEVCKVIKKRGNK.........
G5B2K7_HETGA/366-597                 ...................................................................AKTVISESLTTLGIEMST.QSQHDKIDASEL...SFPFHESILKVIEEEWQQIDRQLP...S...LAC....KYPVSSREATRILSVPKVDDEILGFISEATPPAGVQPASTES.C.N.KHLDIALCRTYEAAASALQIATHSAFVAKATQADISQA.AQILSSDPD.RIP.QAL.E.ILSK.AY.DAASFLCEAAFDEVKMASRTMASSTVGRRHLWLKDCKLSPASKNKLTVAPFKGGTLFG-EVHKIIKKRGNK.........
M7AVU9_CHEMY/106-318                 ......................................krvansqetalhevqekqhkllkilqpas------------------.--------SAKI...TFPMDESITEPAEAIWQTPASAPP...TnkrADR....KYFVPAKGMEFLFSHPQACSLVVEAANQRSKQPHFCCTPQDK.E.H.KRLDLFGCKVYSSATVLLRVANYSALLANYDYSNYSKL.QKLVEDLPK.HKRpQLS.A.VVNE.GQ.IIACTALQASMDVADTAARTVATAVVMRRTSWLQA------------------------------------sverttaks
L9LCW4_TUPCH/532-764                 ...................................................................AKTVVLHSLTTLGIEMSK.DSQHNRIGTSEL...SFPFHESILKVIEEEWQQIDRQLP...S...LAC....KYPISSKEATRILSVPKVDDEIQGFISETTLPAGIQAASTES.C.D.KQLNLALCRSYEAAASALQIATHMAFVAKAMQADISQA.AQILSSDPS.RMH.QAL.G.TLSK.TY.DAASFLCEAAFDEVKMAAHSMGSSTLGLRYLSLKECKINPALKTKLAVTPFRGGTLFGGEVCKVVKKRGNK.........
LAP2A_MOUSE/459-692                  ...................................................................AKSVVSHSLTTLGVEVSKpPPQHDKIEASEP...SFPLHESILKVVEEEWQQIDRQLP...S...VAC....RYPVSSIEAARILSVPKVDDEILGFISEATPRAATQASSTES.C.D.KHLDLALCRSYEAAASALQIAAHTAFVAKSLQADISQA.AQIINSDPS.DAQ.QAL.R.ILNR.TY.DAASYLCDAAFDEVRMSACAMGSSTMGRRYLWLKDCKISPASKNKLTVAPFKGGTLFGGEVHKVIKKRGNK.........
#=GR LAP2A_MOUSE/459-692       SS    ...................................................................XXXXXX-----SS------------------...--BHHHHHHHHHHHHCCGSSS---...-...-TT....TS--B-HHHHHHHS--B--HHHHHCCHHTS---STT---THH.H.H.HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH.HHHHHS-TT.-HH.HHH.H.HHHH.HH.HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTS-S-HHHHHHHHHS---SSBSSTTTCGGTS---XXX.........
M7BLD8_CHEMY/1427-1527               ............................................lsalqgnlstgwkisgrdhlnis------------------.------------...------------------------...-...---....------------------------------------------.-.-.--------------------------------------.---------.---.---.F.ILKR.VS.LATTFIANESIDAMRFTARAMNSSSVTRCPIWLQPWKADLHSKQVLCSAKSTGSLLFGEKLYKLA------adnvak...
Q8VCL4_MOUSE/343-497                 .....................................................aegpiidvlehskr------------------.------------...------------------------...-...---....---------------------------------GNTASPLDS.T.S.KEMEVMGCRFYHAASIAARAASYMAYMTQ-YQRKLWED.MEDLVHDPEfDRG.KAR.C.IISD.GM.DAGLWQLCTTRDIMDSVVRVMAMAVDYRRQAWLRLTSLTKKTQEKILHLPFDGTSLFGQDVNAIVA-----edns.....
LAP2A_HUMAN/461-693                  ...................................................................AKTVVSHSLTTLGLEVAK.QSQHDKIDASEL...SFPFHESILKVIEEEWQQVDRQLP...S...LAC....KYPVSSREATQILSVPKVDDEILGFISEATPLGGIQAASTES.C.N.QQLDLALCRAYEAAASALQIATHTAFVAKAMQADISQA.AQILSSDPS.RTH.QAL.G.ILSK.TY.DAASYICEAAFDEVKMAAHTMGNATVGRRYLWLKDCKINLASKNKLASTPFKGGTLFGGEVCKVIKKRGNK.........
H0VJK1_CAVPO/323-555                 ...................................................................AKTVVSHSLSTLGIEMSN.QSQHDKLDASGL...SFPLHESILKVIEEEWQQVDRELP...S...LAC....KYPVSSREATRILSVPKVDDEILGLIAEGTPAAGVQPASAES.C.D.KHLDLALCRTYEAAASVLQAATHTAFVAKAMQADISQA.AQILSADPS.HAP.QAL.E.MLSR.TY.DAASFLCEAAFDEVKMAACTMASSSGGRRHLWLKDCRLSPASKNKLTVAPFKGGTLFGGEVHKIIKKRGNK.........
S9Y6N0_9CETA/343-575                 ...................................................................AKTVVSHSLTTLGIEMSM.QSQHDKIDAPEL...SFPFHESILKVIEEEWQQIDKQLP...S...LAC....KYPISSREATRILSVPKVDDEILGLITDASPPTGIQAVSNES.C.D.KQLDLALCRTYEAAASALQVATHTAFVVRAMQADISQA.AQILSSEPS.RTH.QAL.G.MLSK.TY.DAALFLCEAAFDEVKMAAHTMGSSTLGRRYLWLKDCKINPASKNKLAVVPFKGGMLLGREGLKIIKKRGNK.........
M7B7Z8_CHEMY/12-161                  ..................................................vkqkkkhqfprstpsdk------------------.------------...------------------------...-...---....------------------------------------------.D.S.RQLDLLGRKVYASSTLQFRIATYSAVLAKYDHKNYNKF.MDFIDHIPE.DKK.QQItA.IVSE.GQ.ILSRTALQAALDVANIAARSTATAVVMRRGSWLSSSSFPRKFQSTIEDLPFDGDKLFASTTNDVL------hsmkd....
L5KIK6_PTEAL/460-688                 ...................................................................AKTVISHSLATLGIEMSK.QSQHDKIDAPEL...SFPFHESMSKVIEEEWQQIDRQLP...S...LAC....KYPVSSEEATQILSVPKVDDEILGFISEATTPSGIQAAST--.-.S.KQLDLALCRAYEAAASTLQIATHTAFVVRAMQAEISQA.AQILSSDPS.HMQ.QAL.G.ILSK.TY.DAASFLCEAAFDEVKMAARIMGSSTLGRRYLWLKDCKINPASKNKLAVIPFKGGTLFGGEVGNVVKKH---sk.......
F6YNY7_CALJA/461-690                 ...................................................................AKTVISHSLTTLGLDMCK.QSQHDKIDASEL...SFPFHESILKVIEEEWQQVDRQLP...S...LAC....KYPVSSREATRILSVPKVDDEILEFISEATPPAGIQAASTES.C.D.KQLDLALCRAYEAAASALQIATHTAFVAKAVQADISQA.AQILSSD--.-TH.QAL.G.ILSK.TY.DAASYICEAAFDEVKMAAHTMGNSTVGRRYLWLKDCKINLASKNKLAATPFKGGTLFGGEVYKVIKKRGNK.........
G3I2N4_CRIGR/90-318                  ............................................................drysdnd-----------EGIEMSE.QPQHDKIDASEP...SFPLHDSILKVIEEEWQQTDRQLP...S...LAC....KYPVSSSEATRILSVPAVDDEILGLVSETTPRAAIQASSTES.C.D.KHLDLALCRSYEAAASALQIAAHTAFVAKSLQANISQA.AQAISADPS.RAP.QAL.E.ILSR.SY.DAASYLCDAAFDEVRMSAYAMGSSTVGRRHLWLKDCKINPASKNKLTVAPFKGGTLFGGDIHKVIKRRGNK.........
S9XDH7_9CETA/281-434                 .......................................................ggpivealahsr------------------.------------...------------------------...-...---....--------------------------------RGSAVSPLDS.A.S.KEMEVMGCRFYHAASIAARAASYMAYMTQ-YQRKLWED.MEDLVHDPEfDRG.KAR.C.IISD.GM.DAGLWQLCTTRDIMDSVVRVMAMAIDYRRQAWLRLTSLTKKTQEKISHLPFDGTSLFGQDVNAVVA-----eens.....
I3MD17_ICTTR/459-691                 ...................................................................AKTVVSHALTTLGMEKSE.KSQHDNIDSSEL...SFPFHESILKVIEEEWQQIDRQLP...S...LAR....KYPISSREATQILSVPKVDDEIQGFISETIPPAGIQEGSAES.C.D.KHLDLTLCRAYTAAASTMQIATHTAFVVKAMQADISQA.AQIISSDPS.RTH.QAL.N.ILSK.TY.DAASFLCEAAFDEVKMAAYTMGSSTLGRRYLWLKDCKINPASKNKLTVTPFKGGTLFGGEVHKVIKKRGKK.........
M7AIL8_CHEMY/3187-3415               ...............................................................reas-----SLSLQAEEVEEPS.DSLFDVLSATALarvALPLHEGVVKISNALWQIL-SSLP...P...ISKraerKYFVPAKGHEYL--YPHPNSLVVKVVNHKEHQGQPAPTPKNK.D.S.RRLDLFGQKLYSSSRFQLRVANHQALLGRYDFNSMPKF.TFALQEHNR.KEY.KAL.-.-VED.GT.AAVRAALQAASDAVDMAARTMASAVSMRRTLWLLLSGLSSEGQSSLQDLPFDDKALFSE------------qtdmklh..
#=GC SS_cons                         ...................................................................XXXXXX-----SS------------------...--BHHHHHHHHHHHHCCGSSS---...-...-TT....TS--B-HHHHHHHS--B--HHHHHCCHHTS---STT---THH.H.H.HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH.HHHHHS-TT.-HH.HHH.H.HHHH.HH.HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTS-S-HHHHHHHHHS---SSBSSTTTCGGTS---XXX.........
#=GC seq_cons                        ..............................................................................................s.t....uhPhH-ul.Kl.pt.WQp.sp.hP...p...htp....+Y.lsu.ttt.lhohPtsss.l.thlsctp..sG.Qssus-S.s.s.KpLDLhhCRsYcAAu.sLplAoHpAals+hhQsclups.uphLssDPp.cpp.QAh.s.ILSc.sh.DAApahhpAAhDtschAA+oMuouslhRRhLWL+pspls.topsKLsshPFcGusLFGt-l.tllt..............
//
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