GenomeNet

Database: Pfam
Entry: LAP2alpha
LinkDB: LAP2alpha
Original site: LAP2alpha 
#=GF ID   LAP2alpha
#=GF AC   PF11560.7
#=GF DE   Lamina-associated polypeptide 2 alpha
#=GF AU   Pollington J
#=GF SE   pdb_2v0x
#=GF GA   25.00 25.00;
#=GF TC   25.30 25.00;
#=GF NC   24.90 24.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   17562312
#=GF RT   Structural basis for dimerization of LAP2alpha, a component of
#=GF RT   the nuclear lamina. 
#=GF RA   Bradley CM, Jones S, Huang Y, Suzuki Y, Kvaratskhelia M, Hickman
#=GF RA   AB, Craigie R, Dyda F; 
#=GF RL   Structure. 2007;15:643-653.
#=GF DR   INTERPRO; IPR021623;
#=GF CC   LAPs are components of the nuclear lamina which supports the
#=GF CC   nuclear envelope.LAP2alpha is a non-membrane-associated member
#=GF CC   of the LAP family which is unique. This family of proteins is
#=GF CC   the C terminal domain of LAP2alpha which consists of residues
#=GF CC   459-693 and constitutes a dimeric structure with an antiparallel
#=GF CC   coiled coil. LAP2alpha is involved in cell-cycle regulation and
#=GF CC   chromatin organisation and preferentially binds to lamin A/C
#=GF CC   [1].
#=GF SQ   44
#=GS G3TD04_LOXAF/460-692        AC G3TD04.1
#=GS W5P749_SHEEP/349-501        AC W5P749.1
#=GS H0X6F2_OTOGA/458-690        AC H0X6F2.1
#=GS S7NMM2_MYOBR/374-591        AC S7NMM2.1
#=GS M7B108_CHEMY/7-137          AC M7B108.1
#=GS M7BJC6_CHEMY/10-147         AC M7BJC6.1
#=GS M7BUZ7_CHEMY/13-222         AC M7BUZ7.1
#=GS F7HAU0_MACMU/462-694        AC F7HAU0.1
#=GS S7MP08_MYOBR/332-485        AC S7MP08.1
#=GS M7BXM2_CHEMY/199-370        AC M7BXM2.1
#=GS M7B3G0_CHEMY/49-254         AC M7B3G0.1
#=GS F6YF13_MACMU/345-498        AC F6YF13.1
#=GS L5JN49_PTEAL/281-434        AC L5JN49.1
#=GS K7F080_PELSI/325-552        AC K7F080.1
#=GS A0A1B8XSR3_XENTR/207-444    AC A0A1B8XSR3.1
#=GS G1LW26_AILME/460-692        AC G1LW26.1
#=GS G3QLH5_GORGO/461-693        AC G3QLH5.1
#=GS M7APM7_CHEMY/12-213         AC M7APM7.1
#=GS M7BZD3_CHEMY/118-344        AC M7BZD3.1
#=GS A0A1B8XUS1_XENTR/1-127      AC A0A1B8XUS1.1
#=GS K7F182_PELSI/104-332        AC K7F182.1
#=GS A0A091E7L8_FUKDA/567-787    AC A0A091E7L8.1
#=GS G7PJ42_MACFA/370-602        AC G7PJ42.1
#=GS G5B2K7_HETGA/366-597        AC G5B2K7.1
#=GS M7AVU9_CHEMY/106-318        AC M7AVU9.1
#=GS L9LCW4_TUPCH/532-764        AC L9LCW4.1
#=GS LAP2A_MOUSE/459-692         AC Q61033.4
#=GS LAP2A_MOUSE/459-692         DR PDB; 2V0X A; 465-685;
#=GS LAP2A_MOUSE/459-692         DR PDB; 2V0X B; 465-689;
#=GS M7BLD8_CHEMY/1427-1527      AC M7BLD8.1
#=GS A0A1B8XUR9_XENTR/205-420    AC A0A1B8XUR9.1
#=GS A0A1B8XUH8_XENTR/2-223      AC A0A1B8XUH8.1
#=GS Q8VCL4_MOUSE/343-497        AC Q8VCL4.1
#=GS LAP2A_HUMAN/461-693         AC P42166.2
#=GS A0A1B8XYH0_XENTR/7-199      AC A0A1B8XYH0.1
#=GS H0VJK1_CAVPO/323-555        AC H0VJK1.1
#=GS M7B7Z8_CHEMY/12-161         AC M7B7Z8.1
#=GS A0A1B8YAA6_XENTR/5-208      AC A0A1B8YAA6.1
#=GS S9Y6N0_CAMFR/343-575        AC S9Y6N0.1
#=GS A0A0Q3LVP9_AMAAE/1388-1605  AC A0A0Q3LVP9.1
#=GS L5KIK6_PTEAL/460-688        AC L5KIK6.1
#=GS F6YNY7_CALJA/461-690        AC F6YNY7.1
#=GS G3I2N4_CRIGR/90-318         AC G3I2N4.1
#=GS S9XDH7_CAMFR/281-434        AC S9XDH7.1
#=GS I3MD17_ICTTR/459-691        AC I3MD17.1
#=GS M7AIL8_CHEMY/3187-3415      AC M7AIL8.1
G3TD04_LOXAF/460-692                   ...................................................................AKTVVSNSLTTLGIEMSK.QSQHDKI....DDYEL...SFPLHESILKVIEEEWQQ..IDRQR..P...S...LA...C....K....YPVSSREAPRILSVPKVDDEIL.GFLSEGSPPAGIQAASSEA.C.D.KQLDLALCRTYEAAASALQIATHAAFVVRAMQADI..SQA.AQILSSDPT.QMH.QAL..R.I.LSK.TY.DAASYLCEAAFDEVKMAAHTMGSSSVGRRYLWLKDCKINPASKNKLAVTPFKGGTLFGGEVCKIIKKRGNK.........
W5P749_SHEEP/349-501                   .....................................................gpivealehsrrgg------------------.-------....-----...------------------..-----..-...-...--...-....-....----------------------.------------TTSPLDS.T.S.KEMEVMGCRFYHAASIAARAASYMAYMTQ-YQRKL..WED.MEDLVHDPEfDRG.KAR..C.I.ISD.GM.DAGLWQLCTTRDIMDSVVRVMAMAIDYRRQAWLRLTSLTKKTQEKISHLPFDGTCLFGQDVNAVVA-----eens.....
H0X6F2_OTOGA/458-690                   ...................................................................AKSVVSHSLTTLGIEMSK.ESQYDKI....HASEP...SFPLHESILKVIEEEWQQ..IDRQL..P...S...LA...C....K....YPISSGEATRILSVPKVDDEIL.GFISEATPPASIQAATTES.C.D.KQLDLALCRAYEAAASALQIATHTAFVAKAMQADI..SQA.ARILSSDPS.RMQ.QAL..G.I.LSK.TY.DAASYICDAAFDEVKISAHTMGNSTVGRRHLWLKECKLNSASKNKLAVTSFKGGTLFGGEVYKVIKKRGNK.........
S7NMM2_MYOBR/374-591                   ...................................................................ATTVVSHSLATLGIEMSK.QSQHDKV....DASEL...SFPFHESILKVIEEEWQQ..IDRQL..P...S...LA...C....K....YPISSKEATQILSVPKVDDEIL.EFISETTPPAGIQVAST--.-.D.KQLDSALCRAYEAAASALQVATHTAFVVRAMQADI..SQA.AQILSSDPS.DSH.QAL..G.I.LSK.TY.DAASFLCEAAFDEVKMAAHTMGSSTLGRRYLWLKDCKINPASKNKLAVTPFKDS-----------------kielk....
M7B108_CHEMY/7-137                     ..........................................hpqlnsllveaanrhskqpqfwstp------------------.-------....-----...------------------..-----..-...-...--...-....-....----------------------.----------------QDK.E.H.KHLDLFGLKAYLSATLQFQVANYSALLAKYNFDNY..SKL.REFLEVLPEeKCP.QFT..A.I.MNE.GQ.LIACTALQALMDIVDTAARTTATAVVIRRVSWIQ-------------------------------------yerapt...
M7BJC6_CHEMY/10-147                    ptpknkysqrldsfgrrlyyplsfqlrvanhqallgryefslwgslpkfedplqehnkkefkalvee------------------.-------....-----...------------------..-----..-...-...--...-....-....----------------------.-------------------.-.-.-----------------------------------..---.---------.---.---..-.-.---.GT.VAARASLQAALDVADMAACSMASVVSMRRALWLLLSGLSSGAQAALQDLPFDSKALFAEQM----------vtklhgmk.
M7BUZ7_CHEMY/13-222                    ............................................................sslapgr------------------.-------....----V...ALPLHKGVAKISNALWQT..LASLA..PiskR...AE...C....K....YFVSAMGHEYLYTHPAPNSLVV.KLVNHREWQRQPDPTSKNK.D.S.RRLDSFGRKIYLSSSFQLWVANHQALLGRYEFNLW..GSL.RKFEDSLQK.HER.KEF..K.V.LVE.EGsAAARATLQAAADAADMAGWSMASAVSLRRALWLLLSGLSSEAQTSLQDLPFDVKALFAE------------qtdtklh..
F7HAU0_MACMU/462-694                   ...................................................................AKTVVSHSLTTLGLEVSK.QSQHDKI....DASEL...SFPFHESILKVIEEEWQQ..VDRQL..P...S...LA...C....R....YPVSSKEATRLLSVPKVDDEIL.GFISEATPPAGIQATSTES.C.D.KQLDLALCRAYEAAASALQIATHTAFVAKAMQADI..SQA.AQILSSDPS.RTH.QAL..G.I.LSK.TY.DAASYICEAAFDEVKMAAHTMGNSTVGRRYLWLKDCKINLASKSKLASTPFKGGTLFGGEVCKVIKKRGNK.........
S7MP08_MYOBR/332-485                   .....................................................egpivealehskrg------------------.-------....-----...------------------..-----..-...-...--...-....-....----------------------.-----------STTSLLDS.T.S.KEMEVMGCRFYHAASIAARAASYMAYMTQ-YQRKL..WED.MEDLVHDPEfDRG.KAR..C.I.ISD.GM.DAGLWQLCTTRDIMDSVVRVMAMAVDYRRQAWLRLTSLTKKTQEKISHLPFDGTSLFGQDVNAVVA-----eens.....
M7BXM2_CHEMY/199-370                   ....................................rkyfapskgyeflfchpspcslvvsainere------------------.-------....-----...------------------..-----..-...-...--...-....-....----------------------.--------RHGQQAPAPEA.ReA.KRLDLFGRKVYSSAGLQLRIANQQAILNRHNFNSW..AAV.GKFKDNLPQ.GSQ.QEF..MtL.VDE.GK.AVAKTSLQASLDSADLVARTIASGVVMRRSAWLQESGLPPEVQNTLQDLPFKGSGLFSD------------qtdtrlh..
M7B3G0_CHEMY/49-254                    ...srvalplirtiqtttriiwqtpvsipptakgvqqkyfvplkgydylfthpqpcslvvasvneke------------------.-------....-----...------------------..-----..-...-...--...-....-....----------------------.--------RHGQQAPAPKS.K.DaKCLDLCGCKVYSSAGLQLRIANQQALLSRYNFNSW..NSM.LKFKELVPP.KSR.EEF..A.A.LAEeGK.TVAQTSLQASLDAADSAAHTLSSGITVRRIFWLQASGLPPELQQTLQDLPFDGACLFSE------------ktnsrlqs.
F6YF13_MACMU/345-498                   ......................................................egpivealehskr------------------.-------....-----...------------------..-----..-...-...--...-....-....----------------------.----------GNTTSPLDS.T.S.KEMEVMGCRFYHAASIAARAASYMAYMTQ-YQRKL..WED.MEDLVHDPEfDRG.KAR..C.I.ISD.GM.DAGLWQLCTTRDIMDSVVRVMAMAIDYRRQAWLRLTSLTKKTQEKISHLPFDGTSLFGQDVKAVVA-----eens.....
L5JN49_PTEAL/281-434                   ......................................................egpivealehskr------------------.-------....-----...------------------..-----..-...-...--...-....-....----------------------.----------GSTTSPLDS.T.S.KEMEVMGCRFYHAASIAARAASYMAYMTQ-YQRKL..WED.MEDLVHDPEfDRG.KAR..C.I.ISD.GM.DAGLWQLCTTRDIMDSVVRVMAMAVDYRRQAWLRLTSLTKKTQEKISHLPFDGTSLFGQDVNAVVA-----eens.....
K7F080_PELSI/325-552                   .................................................advnvkqykllknlhprq------------------.-------....-QSKV...ALPLDEAILEPATEIWKT..PASTT..P...S...CKraeK....R....YFISSKGAEFLFTHPQPNSLVV.DAALQRAKNPQVRNSAADK.D.A.KRLDIFGRKVYSSSTLLLRIANYSALLSNHSFDNI..AKL.SEIAQR-IS.ETD.KVLlrA.I.LQE.GY.ACARAGLQIAMDVADTAARSIATAVSMRRASWLATAAVPKELQSKVEDLPFDRIKLFAEKTDEV-------lhtgkd...
A0A1B8XSR3_XENTR/207-444               .....................................krllremmqtleikdetvplsradkllgvq------------------.-------....KKSKL...AFPVFNSLTQANEAEWAQ..PERRI..AltqR...FF...K....T....YPVPEEHQKKWDRAPKVDSAVA.-RLSRQTAIPAEEAAFKDP.L.D.RRMESILKRSYTQAAAILRPAVASAGLARTARH--..-WA.LELARHPPS.SK-.QQL..Q.LeVDR.LS.TTLSFLAESALEITRLAAKATSNAVVARRALWLRHWTGDTASKRRLLSLKFTGESLFGPDLKQIIS-----dvtggk...
G1LW26_AILME/460-692                   ...................................................................AKTVVSHSLTTLGIEMSK.QSQHEKI....DASEL...SFPFHESILKVIEEEWQQ..IDRQL..P...S...LA...C....K....YPISSREATQILSVPKVDDEIL.EFISEATPPVGIQAASTES.C.D.KQLDLVLCRTYEAAASALQIATHTAFVVKALQADI..SQV.AQILSSDPS.HMH.QAL..G.I.LSK.TY.DAASFLCEAAFDEVKMAAHSMGSSTLGRRYLWLKDCKINPASKNKLVVTPFKGGTLFGGEVCKVTKKRGNK.........
G3QLH5_GORGO/461-693                   ...................................................................AKTVVSHSLTTLGLEVAK.QSQHDKI....DASEL...SFPFHESILKVIEEEWQQ..VDRQL..P...S...LA...C....K....YPVSSREATQILSVPKVDDEIL.GFISEATPLAGIQAASTES.C.N.QQLDLALCRAYEAAASALQIATHTAFVAKAMQADI..SQA.AQILSSDPS.RTH.QAL..G.I.LSK.TY.DAASYICEAAFDEVKMAAHTMGNSTVGRRYLWLKDCKINLASKNKLASTPFKGGTLFGGEVCKVIKKRGNK.........
M7APM7_CHEMY/12-213                    rialpliktiqsnyktiwqtpassapmakgverkyfapskgyvflfchpspcslvvsavderewhgq------------------.-------....-----...------------------..-----..-...-...--...-....-....----------------------.------------QATAPKAkE.A.KCLDLFGRKVYSSGGLQLRIANHQATLNRHNFSSW..AAV.GKFKDNLPQ.GSQ.QQF.tA.L.VDK.GK.TVAKTSLQASLDSADMVARTVTSGVVMRCSVWLQESGLPPKVQNTLQDLPFKGSGLFSD------------qtdmr....
M7BZD3_CHEMY/118-344                   ..................................................vafnlglqaeeleepsd------------------.-SLFDIL....CASAParvALLIHEGVSKITNALWQT..PSSLA..PiskR...AE...C....K....YFMPTKGHEYLYSHPAPNSLVV.QVINHKERQGQLRATPKNK.D.S.RWLDLFGRKIYLSSSLQLRVANHQALLGQY-DFNM..WQAmAKFEGSLPE.ASK.KEF..RaI.LNE.GT.NAARAALQVASDVADAAACTMASAISMQQASWLLLSGLSTEAQQSMQDLCFD-------------------gwataasg.
A0A1B8XUS1_XENTR/1-127                 ................................................................mes------------------.-------....-----...------------------..-----..-...-...--...-....-....----------------------.-------------------.-.-.-----ILKRSYTQAAAILRPAVASAGLARTARH--..--W.ALELARHPP.ASK.QQL..Q.LeVDK.LS.TTLSFLAESALEITRLAAKATSNAVVARRALWLRHWSGDTASKMRLLSLKFTGESLFGPDLKQIIS-----dvtggk...
K7F182_PELSI/104-332                   ............................................vqlseaqvkqhkllknlhpqqrc------------------.-------....---RI...ALPSDEAIMDMAHEIWQT..PTSIP..P...Ts.kRA...D....K....YFVPSKDMGFLFNHPQPNSLIV.DAARHKNKTSQFRSSLPDK.G.T.RKLDLFGCKMYSSSTLMLRIANYAALLSNHNFDNY..AKL.PELMQHLPE.AKR.PLL..KaI.VQE.GY.TAWRTLLQIALDVTDTAARAMATGIAMRRASWLMASGAPKELQNKVEDLPFDRKRLFAASTDDV-------lhsgk....
A0A091E7L8_FUKDA/567-787               ...................................................................AKAVISHSLTALGIEMSN.QSQHDKI....EASEL...SFPFHESILKVIEEEWQQ..IDRQL..P...S...LA...C....K....YPVSAREATRILSVPKVDDEIL.GFISEATPPAGIQPASAES.C.D.KHLDLALCRTYETTASALQIATHSAFVAKAMQADI..SQA.AQILSSDPS.RTP.QVL..E.I.LSK.TY.DAASFLCEAAFDEVRVSARTMASSTVGRRHLWLKDCKISPASKNKLTVAPFKDS-----------------kielk....
G7PJ42_MACFA/370-602                   ...................................................................AKTVVSHSLTTLGLEVSK.QSQHDKI....DASEL...SFPFHESILKVIEEEWQQ..VDRQL..P...S...LA...C....R....YPVSSKEATRLLSVPKVDDEIL.GFISEATPPAGIQATSTES.C.D.KQLDLALCRAYEAAASALQIATHTAFVAKAMQADI..SQA.AQILSSDPS.RTH.QAL..G.I.LSK.TY.DAASYICEAAFDEVKMAAHTMGNSTVGRRYLWLKDCKINLASKSKLASTPFKGGTLFGGEVCKVIKKRGNK.........
G5B2K7_HETGA/366-597                   ...................................................................AKTVISESLTTLGIEMST.QSQHDKI....DASEL...SFPFHESILKVIEEEWQQ..IDRQL..P...S...LA...C....K....YPVSSREATRILSVPKVDDEIL.GFISEATPPAGVQPASTES.C.N.KHLDIALCRTYEAAASALQIATHSAFVAKATQADI..SQA.AQILSSDPD.RIP.QAL..E.I.LSK.AY.DAASFLCEAAFDEVKMASRTMASSTVGRRHLWLKDCKLSPASKNKLTVAPFKGGTLFG-EVHKIIKKRGNK.........
M7AVU9_CHEMY/106-318                   ......................................krvansqetalhevqekqhkllkilqpas------------------.-------....-SAKI...TFPMDESITEPAEAIWQT..PASAP..P...TnkrAD...R....K....YFVPAKGMEFLFSHPQACSLVV.EAANQRSKQPHFCCTPQDK.E.H.KRLDLFGCKVYSSATVLLRVANYSALLANYDYSNY..SKL.QKLVEDLPK.HKRpQLS..A.V.VNE.GQ.IIACTALQASMDVADTAARTVATAVVMRRTSWLQA------------------------------------sverttaks
L9LCW4_TUPCH/532-764                   ...................................................................AKTVVLHSLTTLGIEMSK.DSQHNRI....GTSEL...SFPFHESILKVIEEEWQQ..IDRQL..P...S...LA...C....K....YPISSKEATRILSVPKVDDEIQ.GFISETTLPAGIQAASTES.C.D.KQLNLALCRSYEAAASALQIATHMAFVAKAMQADI..SQA.AQILSSDPS.RMH.QAL..G.T.LSK.TY.DAASFLCEAAFDEVKMAAHSMGSSTLGLRYLSLKECKINPALKTKLAVTPFRGGTLFGGEVCKVVKKRGNK.........
LAP2A_MOUSE/459-692                    ...................................................................AKSVVSHSLTTLGVEVSKpPPQHDKI....EASEP...SFPLHESILKVVEEEWQQ..IDRQL..P...S...VA...C....R....YPVSSIEAARILSVPKVDDEIL.GFISEATPRAATQASSTES.C.D.KHLDLALCRSYEAAASALQIAAHTAFVAKSLQADI..SQA.AQIINSDPS.DAQ.QAL..R.I.LNR.TY.DAASYLCDAAFDEVRMSACAMGSSTMGRRYLWLKDCKISPASKNKLTVAPFKGGTLFGGEVHKVIKKRGNK.........
#=GR LAP2A_MOUSE/459-692         SS    ...................................................................XXXXXX-----SS-------------....-----...--BHHHHHHHHHHHHCCG..SSS--..-...-...-T...T....T....S--B-HHHHHHHS--B--HHHH.HCCHHTS---STT---THH.H.H.HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH..HHH.HHHHHS-TT.-HH.HHH..H.H.HHH.HH.HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTS-S-HHHHHHHHHS---SSBSSTTTCGGTS---XXX.........
M7BLD8_CHEMY/1427-1527                 ............................................lsalqgnlstgwkisgrdhlnis------------------.-------....-----...------------------..-----..-...-...--...-....-....----------------------.-------------------.-.-.-----------------------------------..---.---------.---.---..F.I.LKR.VS.LATTFIANESIDAMRFTARAMNSSSVTRCPIWLQPWKADLHSKQVLCSAKSTGSLLFGEKLYKLA------adnvak...
A0A1B8XUR9_XENTR/205-420               .......................................llremmqtleikdetvplsradkllgvq------------------.-------....KKSKL...AFPVFNSLTQAIEAEWAQ..PERRI..AltqR...FF...K....T....YPVPEEHQKKWDKAPKVDSAVA.-RLSRQTAIPAEEAAFKDP.L.D.RRMESILKRSYTQAAAILRPAVASAGLARTARH--..--W.ALELARHPP.ASK.QQL..Q.LeVDK.LS.TTLSFLAESALEITRLAAKATSNAVVARRALWLRHWSGDTASKMR--------------------------ssrtgpg..
A0A1B8XUH8_XENTR/2-223                 ........................................................qtleikdetvt------------------.RSKADKLlgvqKRSKL...AFPVFNSLTQAIEAERNQ..PERRI..AltqR...FF...K....T....YPVPEEYQKKWDRAPKVDS-VV.ARLSRQTALPAEEAAFKDP.L.D.RRMESVLKRSYTQAAAILRPAVASAGLARTAK---..-HW.AQELARHPP.SSK.QQL.qT.E.VDK.LS.TTLSFLAEAATEITKLAAKATANTVVARRALWMRHWTGDTASKMKLLSLKFTGESLFGR------------sslct....
Q8VCL4_MOUSE/343-497                   .....................................................aegpiidvlehskr------------------.-------....-----...------------------..-----..-...-...--...-....-....----------------------.----------GNTASPLDS.T.S.KEMEVMGCRFYHAASIAARAASYMAYMTQ-YQRKL..WED.MEDLVHDPEfDRG.KAR..C.I.ISD.GM.DAGLWQLCTTRDIMDSVVRVMAMAVDYRRQAWLRLTSLTKKTQEKILHLPFDGTSLFGQDVNAIVA-----edns.....
LAP2A_HUMAN/461-693                    ...................................................................AKTVVSHSLTTLGLEVAK.QSQHDKI....DASEL...SFPFHESILKVIEEEWQQ..VDRQL..P...S...LA...C....K....YPVSSREATQILSVPKVDDEIL.GFISEATPLGGIQAASTES.C.N.QQLDLALCRAYEAAASALQIATHTAFVAKAMQADI..SQA.AQILSSDPS.RTH.QAL..G.I.LSK.TY.DAASYICEAAFDEVKMAAHTMGNATVGRRYLWLKDCKINLASKNKLASTPFKGGTLFGGEVCKVIKKRGNK.........
A0A1B8XYH0_XENTR/7-199                 ..............................................................ikdet------------------.-------....-----...----------AIEAEWAQ..PERRI..AltqR...FF...K....T....YPVPEEHQKKWDKAPKVDSAVA.-RLSRQTAIPAEEAAFKDP.L.D.RRMESILKRSYTQAAAILRPAVASAGLARTARH--..--W.ALELARHPP.ASK.QQL..Q.LeVDK.LS.TTLSFLAESTLEITRLAAKATSNAVVARRALWLRYWTGDTASKMRLLSLKFTGESLFGPDLKQII------sd.......
H0VJK1_CAVPO/323-555                   ...................................................................AKTVVSHSLSTLGIEMSN.QSQHDKL....DASGL...SFPLHESILKVIEEEWQQ..VDREL..P...S...LA...C....K....YPVSSREATRILSVPKVDDEIL.GLIAEGTPAAGVQPASAES.C.D.KHLDLALCRTYEAAASVLQAATHTAFVAKAMQADI..SQA.AQILSADPS.HAP.QAL..E.M.LSR.TY.DAASFLCEAAFDEVKMAACTMASSSGGRRHLWLKDCRLSPASKNKLTVAPFKGGTLFGGEVHKIIKKRGNK.........
M7B7Z8_CHEMY/12-161                    ..................................................vkqkkkhqfprstpsdk------------------.-------....-----...------------------..-----..-...-...--...-....-....----------------------.-------------------.D.S.RQLDLLGRKVYASSTLQFRIATYSAVLAKYDHKNY..NKF.MDFIDHIPE.DKK.QQI.tA.I.VSE.GQ.ILSRTALQAALDVANIAARSTATAVVMRRGSWLSSSSFPRKFQSTIEDLPFDGDKLFASTTNDVL------hsmkd....
A0A1B8YAA6_XENTR/5-208                 ..............................................................rrvse------------------.-------....-----...----------LISSEWSK..AAKKIsfN...T...LA...T....RfsklYPFKEQETKDWDSPPAVDPAVI.HVSKKTTLPIDDSSVLKDP.M.D.RRVETELRKVYQVAGASCKPAVALVSVAKAVSLWI..DSL.DKAV-SDGT.DAA.DIS..A.G.LSE.LK.MAVAFMSEAAVDMTRLASRSMAVSVSARRALWLRAWGADTASKVSLCNLPYVGGSLFGPKLDEVISKA---tggk.....
S9Y6N0_CAMFR/343-575                   ...................................................................AKTVVSHSLTTLGIEMSM.QSQHDKI....DAPEL...SFPFHESILKVIEEEWQQ..IDKQL..P...S...LA...C....K....YPISSREATRILSVPKVDDEIL.GLITDASPPTGIQAVSNES.C.D.KQLDLALCRTYEAAASALQVATHTAFVVRAMQADI..SQA.AQILSSEPS.RTH.QAL..G.M.LSK.TY.DAALFLCEAAFDEVKMAAHTMGSSTLGRRYLWLKDCKINPASKNKLAVVPFKGGMLLGREGLKIIKKRGNK.........
A0A0Q3LVP9_AMAAE/1388-1605             ........................................................lflpseegkvn------------------.-------....----N...ALPIHSAVEDLVCRIWGQpeAKHEA..P...S...VL...S....K...lYPFPVDKAALWGTLPQVDRALVtGDYVLSVP-ANTDALPKDP.T.D.RKVEEAIKRSFKLVAAQLAVSIYSTYASRALLIWLeeEQA.RYRKKWVPS.GAM.QRK..R.R.LCK.T-.-AANFIHDAAEDSLRLTVKNMACLTVAWRAIWLRPWASSLDLKCKLLSLPYTGGKLFGESLVQIMKD----fseh.....
L5KIK6_PTEAL/460-688                   ...................................................................AKTVISHSLATLGIEMSK.QSQHDKI....DAPEL...SFPFHESMSKVIEEEWQQ..IDRQL..P...S...LA...C....K....YPVSSEEATQILSVPKVDDEIL.GFISEATTPSGIQAAST--.-.S.KQLDLALCRAYEAAASTLQIATHTAFVVRAMQAEI..SQA.AQILSSDPS.HMQ.QAL..G.I.LSK.TY.DAASFLCEAAFDEVKMAARIMGSSTLGRRYLWLKDCKINPASKNKLAVIPFKGGTLFGGEVGNVVKKH---sk.......
F6YNY7_CALJA/461-690                   ...................................................................AKTVISHSLTTLGLDMCK.QSQHDKI....DASEL...SFPFHESILKVIEEEWQQ..VDRQL..P...S...LA...C....K....YPVSSREATRILSVPKVDDEIL.EFISEATPPAGIQAASTES.C.D.KQLDLALCRAYEAAASALQIATHTAFVAKAVQADI..SQA.AQILSSD--.-TH.QAL..G.I.LSK.TY.DAASYICEAAFDEVKMAAHTMGNSTVGRRYLWLKDCKINLASKNKLAATPFKGGTLFGGEVYKVIKKRGNK.........
G3I2N4_CRIGR/90-318                    ............................................................drysdnd-----------EGIEMSE.QPQHDKI....DASEP...SFPLHDSILKVIEEEWQQ..TDRQL..P...S...LA...C....K....YPVSSSEATRILSVPAVDDEIL.GLVSETTPRAAIQASSTES.C.D.KHLDLALCRSYEAAASALQIAAHTAFVAKSLQANI..SQA.AQAISADPS.RAP.QAL..E.I.LSR.SY.DAASYLCDAAFDEVRMSAYAMGSSTVGRRHLWLKDCKINPASKNKLTVAPFKGGTLFGGDIHKVIKRRGNK.........
S9XDH7_CAMFR/281-434                   .......................................................ggpivealahsr------------------.-------....-----...------------------..-----..-...-...--...-....-....----------------------.---------RGSAVSPLDS.A.S.KEMEVMGCRFYHAASIAARAASYMAYMTQ-YQRKL..WED.MEDLVHDPEfDRG.KAR..C.I.ISD.GM.DAGLWQLCTTRDIMDSVVRVMAMAIDYRRQAWLRLTSLTKKTQEKISHLPFDGTSLFGQDVNAVVA-----eens.....
I3MD17_ICTTR/459-691                   ...................................................................AKTVVSHALTTLGMEKSE.KSQHDNI....DSSEL...SFPFHESILKVIEEEWQQ..IDRQL..P...S...LA...R....K....YPISSREATQILSVPKVDDEIQ.GFISETIPPAGIQEGSAES.C.D.KHLDLTLCRAYTAAASTMQIATHTAFVVKAMQADI..SQA.AQIISSDPS.RTH.QAL..N.I.LSK.TY.DAASFLCEAAFDEVKMAAYTMGSSTLGRRYLWLKDCKINPASKNKLTVTPFKGGTLFGGEVHKVIKKRGKK.........
M7AIL8_CHEMY/3187-3415                 ...............................................................reas-----SLSLQAEEVEEPS.DSLFDVL....SATALarvALPLHEGVVKISNALWQI..L-SSL..P...P...IS...KraerK....YFVPAKGHEYL--YPHPNSLVV.KVVNHKEHQGQPAPTPKNK.D.S.RRLDLFGQKLYSSSRFQLRVANHQALLGRYDFNSM..PKF.TFALQEHNR.KEY.KAL..-.-.VED.GT.AAVRAALQAASDAVDMAARTMASAVSMRRTLWLLLSGLSSEGQSSLQDLPFDDKALFSE------------qtdmklh..
#=GC SS_cons                           ...................................................................XXXXXX-----SS-------------....-----...--BHHHHHHHHHHHHCCG..SSS--..-...-...-T...T....T....S--B-HHHHHHHS--B--HHHH.HCCHHTS---STT---THH.H.H.HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH..HHH.HHHHHS-TT.-HH.HHH..H.H.HHH.HH.HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTS-S-HHHHHHHHHS---SSBSSTTTCGGTS---XXX.........
#=GC seq_cons                          .........................................................................................................uhPh.pul.phhpt.Wtp...tpth..s...p...h....p....p....Y.lstpttt.h.phPtsss.lh.thhsctp..su.psust-s.s.s.KpLDlhhCRsYpuAu.tLplAsasAhlu+thpssl..sps.sphLspcPp.cpp.Qtl..t.I.lsc.sh.sAAsahhpAAhD.schAA+oMususlsRRtLWL+tspls.topsKLtshPFcGssLFGtcl.tlh...............
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