GenomeNet

Database: Pfam
Entry: LAP2alpha
LinkDB: LAP2alpha
Original site: LAP2alpha 
#=GF ID   LAP2alpha
#=GF AC   PF11560.4
#=GF DE   Lamina-associated polypeptide 2 alpha
#=GF AU   Pollington J
#=GF SE   pdb_2v0x
#=GF GA   25.00 25.00;
#=GF TC   25.30 25.00;
#=GF NC   24.90 24.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   17562312
#=GF RT   Structural basis for dimerization of LAP2alpha, a component of
#=GF RT   the nuclear lamina. 
#=GF RA   Bradley CM, Jones S, Huang Y, Suzuki Y, Kvaratskhelia M, Hickman
#=GF RA   AB, Craigie R, Dyda F; 
#=GF RL   Structure. 2007;15:643-653.
#=GF DR   INTERPRO; IPR021623;
#=GF CC   LAPs are components of the nuclear lamina which supports the
#=GF CC   nuclear envelope.LAP2alpha is a non-membrane-associated member
#=GF CC   of the LAP family which is unique. This family of proteins is
#=GF CC   the C terminal domain of LAP2alpha which consists of residues
#=GF CC   459-693 and constitutes a dimeric structure with an antiparallel
#=GF CC   coiled coil. LAP2alpha is involved in cell-cycle regulation and
#=GF CC   chromatin organisation and preferentially binds to lamin A/C
#=GF CC   [1].
#=GF SQ   46
#=GS G3TD04_LOXAF/460-692    AC G3TD04.1
#=GS Q80TA4_MOUSE/348-502    AC Q80TA4.1
#=GS W5P749_SHEEP/349-501    AC W5P749.1
#=GS H0X6F2_OTOGA/458-690    AC H0X6F2.1
#=GS S7NMM2_MYOBR/374-591    AC S7NMM2.1
#=GS M7B108_CHEMY/7-137      AC M7B108.1
#=GS M7BJC6_CHEMY/10-147     AC M7BJC6.1
#=GS M7BUZ7_CHEMY/13-222     AC M7BUZ7.1
#=GS F7HAU0_MACMU/462-694    AC F7HAU0.1
#=GS G7N578_MACMU/370-602    AC G7N578.1
#=GS S7MP08_MYOBR/332-485    AC S7MP08.1
#=GS M7BXM2_CHEMY/199-370    AC M7BXM2.1
#=GS M7B3G0_CHEMY/49-254     AC M7B3G0.1
#=GS F6YF13_MACMU/345-498    AC F6YF13.1
#=GS D2HE43_AILME/462-694    AC D2HE43.1
#=GS L5JN49_PTEAL/281-434    AC L5JN49.1
#=GS U6DQ72_NEOVI/279-511    AC U6DQ72.1
#=GS K7F080_PELSI/325-552    AC K7F080.1
#=GS G1LW26_AILME/460-692    AC G1LW26.1
#=GS G3QLH5_GORGO/461-693    AC G3QLH5.1
#=GS M7APM7_CHEMY/12-213     AC M7APM7.1
#=GS M7BZD3_CHEMY/118-344    AC M7BZD3.1
#=GS K7F182_PELSI/104-332    AC K7F182.1
#=GS G7PJ42_MACFA/370-602    AC G7PJ42.1
#=GS G5B2K7_HETGA/366-597    AC G5B2K7.1
#=GS M7AVU9_CHEMY/106-318    AC M7AVU9.1
#=GS L9LCW4_TUPCH/532-764    AC L9LCW4.1
#=GS LAP2A_MOUSE/459-692     AC Q61033.4
#=GS LAP2A_MOUSE/459-692     DR PDB; 2V0X A; 465-685;
#=GS LAP2A_MOUSE/459-692     DR PDB; 2V0X B; 465-689;
#=GS G9KUB8_MUSPF/410-507    AC G9KUB8.1
#=GS M7BLD8_CHEMY/1427-1527  AC M7BLD8.1
#=GS U3DHN1_CALJA/461-690    AC U3DHN1.1
#=GS L8I1S6_9CETA/456-688    AC L8I1S6.1
#=GS U3FW61_CALJA/345-498    AC U3FW61.1
#=GS Q8VCL4_MOUSE/343-497    AC Q8VCL4.1
#=GS LAP2A_HUMAN/461-693     AC P42166.2
#=GS Q9CUK0_MOUSE/343-497    AC Q9CUK0.3
#=GS H0VJK1_CAVPO/323-555    AC H0VJK1.1
#=GS M7B7Z8_CHEMY/12-161     AC M7B7Z8.1
#=GS S9Y6N0_9CETA/343-575    AC S9Y6N0.1
#=GS L5KIK6_PTEAL/460-688    AC L5KIK6.1
#=GS F6YNY7_CALJA/461-690    AC F6YNY7.1
#=GS G3I2N4_CRIGR/90-318     AC G3I2N4.1
#=GS S9XDH7_9CETA/281-434    AC S9XDH7.1
#=GS I3MD17_SPETR/459-691    AC I3MD17.1
#=GS K7C541_PANTR/461-693    AC K7C541.1
#=GS M7AIL8_CHEMY/3187-3415  AC M7AIL8.1
G3TD04_LOXAF/460-692               ...................................................................AKTVVSNSLTTLGIEMSK.QSQHDKIDDYEL...SFPLHESILKVIEEEWQQIDRQRP...S...LA...C....KYPVSSREAPRILSVPKVDDEILGFLSEGSPPAGIQAASSEA.C.D.KQLDLALCRTYEAAASALQIATHAAFVVRAMQADISQA.AQILSSDPT.QMH.QAL..R.ILSK.TY.DAASYLCEAAFDEVKMAAHTMGSSSVGRRYLWLKDCKINPASKNKLAVTPFKGGTLFGGEVCKIIKKRGNK.........
Q80TA4_MOUSE/348-502               .....................................................aegpiidvlehskr------------------.------------...------------------------...-...--...-....---------------------------------GNTASPLDS.T.S.KEMEVMGCRFYHAASIAARAASYMAYMTQ-YQRKLWED.MEDLVHDPEfDRG.KAR..C.IISD.GM.DAGLWQLCTTRDIMDSVVRVMAMAVDYRRQAWLRLTSLTKKTQEKILHLPFDGTSLFGQDVNAIVA-----edns.....
W5P749_SHEEP/349-501               .....................................................gpivealehsrrgg------------------.------------...------------------------...-...--...-....-----------------------------------TTSPLDS.T.S.KEMEVMGCRFYHAASIAARAASYMAYMTQ-YQRKLWED.MEDLVHDPEfDRG.KAR..C.IISD.GM.DAGLWQLCTTRDIMDSVVRVMAMAIDYRRQAWLRLTSLTKKTQEKISHLPFDGTCLFGQDVNAVVA-----eens.....
H0X6F2_OTOGA/458-690               ...................................................................AKSVVSHSLTTLGIEMSK.ESQYDKIHASEP...SFPLHESILKVIEEEWQQIDRQLP...S...LA...C....KYPISSGEATRILSVPKVDDEILGFISEATPPASIQAATTES.C.D.KQLDLALCRAYEAAASALQIATHTAFVAKAMQADISQA.ARILSSDPS.RMQ.QAL..G.ILSK.TY.DAASYICDAAFDEVKISAHTMGNSTVGRRHLWLKECKLNSASKNKLAVTSFKGGTLFGGEVYKVIKKRGNK.........
S7NMM2_MYOBR/374-591               ...................................................................ATTVVSHSLATLGIEMSK.QSQHDKVDASEL...SFPFHESILKVIEEEWQQIDRQLP...S...LA...C....KYPISSKEATQILSVPKVDDEILEFISETTPPAGIQVAST--.-.D.KQLDSALCRAYEAAASALQVATHTAFVVRAMQADISQA.AQILSSDPS.DSH.QAL..G.ILSK.TY.DAASFLCEAAFDEVKMAAHTMGSSTLGRRYLWLKDCKINPASKNKLAVTPFKDS-----------------kielk....
M7B108_CHEMY/7-137                 ..........................................hpqlnsllveaanrhskqpqfwstp------------------.------------...------------------------...-...--...-....---------------------------------------QDK.E.H.KHLDLFGLKAYLSATLQFQVANYSALLAKYNFDNYSKL.REFLEVLPEeKCP.QFT..A.IMNE.GQ.LIACTALQALMDIVDTAARTTATAVVIRRVSWIQ-------------------------------------yerapt...
M7BJC6_CHEMY/10-147                ptpknkysqrldsfgrrlyyplsfqlrvanhqallgryefslwgslpkfedplqehnkkefkalvee------------------.------------...------------------------...-...--...-....------------------------------------------.-.-.--------------------------------------.---------.---.---..-.----.GT.VAARASLQAALDVADMAACSMASVVSMRRALWLLLSGLSSGAQAALQDLPFDSKALFAEQM----------vtklhgmk.
M7BUZ7_CHEMY/13-222                ............................................................sslapgr------------------.-----------V...ALPLHKGVAKISNALWQTLASLAPiskR...AE...C....KYFVSAMGHEYLYTHPAPNSLVVKLVNHREWQRQPDPTSKNK.D.S.RRLDSFGRKIYLSSSFQLWVANHQALLGRYEFNLWGSL.RKFEDSLQK.HER.KEF..K.VLVE.EGsAAARATLQAAADAADMAGWSMASAVSLRRALWLLLSGLSSEAQTSLQDLPFDVKALFAE------------qtdtklh..
F7HAU0_MACMU/462-694               ...................................................................AKTVVSHSLTTLGLEVSK.QSQHDKIDASEL...SFPFHESILKVIEEEWQQVDRQLP...S...LA...C....RYPVSSKEATRLLSVPKVDDEILGFISEATPPAGIQATSTES.C.D.KQLDLALCRAYEAAASALQIATHTAFVAKAMQADISQA.AQILSSDPS.RTH.QAL..G.ILSK.TY.DAASYICEAAFDEVKMAAHTMGNSTVGRRYLWLKDCKINLASKSKLASTPFKGGTLFGGEVCKVIKKRGNK.........
G7N578_MACMU/370-602               ...................................................................AKTVVSHSLTTLGLEVSK.QSQHDKIDASEL...SFPFHESILKVIEEEWQQVDRQLP...S...LA...C....RYPVSSKEATRLLSVPKVDDEILGFISEATPPAGIQATSTES.C.D.KQLDLALCRAYEAAASALQIATHTAFVAKAMQADISQA.AQILSSDPS.RTH.QAL..G.ILSK.TY.DAASYICEAAFDEVKMAAHTMGNSTVGRRYLWLKDCKINLASKSKLASTPFKGGTLFGGEVCKVIKKRGNK.........
S7MP08_MYOBR/332-485               .....................................................egpivealehskrg------------------.------------...------------------------...-...--...-....----------------------------------STTSLLDS.T.S.KEMEVMGCRFYHAASIAARAASYMAYMTQ-YQRKLWED.MEDLVHDPEfDRG.KAR..C.IISD.GM.DAGLWQLCTTRDIMDSVVRVMAMAVDYRRQAWLRLTSLTKKTQEKISHLPFDGTSLFGQDVNAVVA-----eens.....
M7BXM2_CHEMY/199-370               ....................................rkyfapskgyeflfchpspcslvvsainere------------------.------------...------------------------...-...--...-....-------------------------------RHGQQAPAPEA.ReA.KRLDLFGRKVYSSAGLQLRIANQQAILNRHNFNSWAAV.GKFKDNLPQ.GSQ.QEF..MtLVDE.GK.AVAKTSLQASLDSADLVARTIASGVVMRRSAWLQESGLPPEVQNTLQDLPFKGSGLFSD------------qtdtrlh..
M7B3G0_CHEMY/49-254                ...srvalplirtiqtttriiwqtpvsipptakgvqqkyfvplkgydylfthpqpcslvvasvneke------------------.------------...------------------------...-...--...-....-------------------------------RHGQQAPAPKS.K.DaKCLDLCGCKVYSSAGLQLRIANQQALLSRYNFNSWNSM.LKFKELVPP.KSR.EEF..A.ALAEeGK.TVAQTSLQASLDAADSAAHTLSSGITVRRIFWLQASGLPPELQQTLQDLPFDGACLFSE------------ktnsrlqs.
F6YF13_MACMU/345-498               ......................................................egpivealehskr------------------.------------...------------------------...-...--...-....---------------------------------GNTTSPLDS.T.S.KEMEVMGCRFYHAASIAARAASYMAYMTQ-YQRKLWED.MEDLVHDPEfDRG.KAR..C.IISD.GM.DAGLWQLCTTRDIMDSVVRVMAMAIDYRRQAWLRLTSLTKKTQEKISHLPFDGTSLFGQDVKAVVA-----eens.....
D2HE43_AILME/462-694               ...................................................................AKTVVSHSLTTLGIEMSK.QSQHEKIDASEL...SFPFHESILKVIEEEWQQIDRQLP...S...LA...C....KYPISSREATQILSVPKVDDEILEFISEATPPVGIQAASTES.C.D.KQLDLVLCRTYEAAASALQIATHTAFVVKALQADISQV.AQILSSDPS.HMH.QAL..G.ILSK.TY.DAASFLCEAAFDEVKMAAHSMGSSTLGRRYLWLKDCKINPASKNKLVVTPFKGGTLFGGEVCKVTKKRGNK.........
L5JN49_PTEAL/281-434               ......................................................egpivealehskr------------------.------------...------------------------...-...--...-....---------------------------------GSTTSPLDS.T.S.KEMEVMGCRFYHAASIAARAASYMAYMTQ-YQRKLWED.MEDLVHDPEfDRG.KAR..C.IISD.GM.DAGLWQLCTTRDIMDSVVRVMAMAVDYRRQAWLRLTSLTKKTQEKISHLPFDGTSLFGQDVNAVVA-----eens.....
U6DQ72_NEOVI/279-511               ...................................................................AKTVVSHSLTTLGIEVSK.QSQHENIDAPEL...SFPFHESILKVIEEEWQQIDKQLP...S...LA...C....KYPISSREATQILSVPKVDDEILEFISEATPPVGIQAASMDS.C.D.KQLDLVLCRTYEAAASALQIATHTAFVVRALQADISQA.AQILSSDPS.HLH.QAL..G.ILSK.TY.DAASFLCEAAFDEVKMAAHSMGSSTLGRRHLWLKDCKINPASKNKLVVTPFKGGTLFGGEVYKVTKKRGNK.........
K7F080_PELSI/325-552               .................................................advnvkqykllknlhprq------------------.--------QSKV...ALPLDEAILEPATEIWKTPASTTP...S...CKraeK....RYFISSKGAEFLFTHPQPNSLVVDAALQRAKNPQVRNSAADK.D.A.KRLDIFGRKVYSSSTLLLRIANYSALLSNHSFDNIAKL.SEIAQR-IS.ETD.KVLlrA.ILQE.GY.ACARAGLQIAMDVADTAARSIATAVSMRRASWLATAAVPKELQSKVEDLPFDRIKLFAEKTDEV-------lhtgkd...
G1LW26_AILME/460-692               ...................................................................AKTVVSHSLTTLGIEMSK.QSQHEKIDASEL...SFPFHESILKVIEEEWQQIDRQLP...S...LA...C....KYPISSREATQILSVPKVDDEILEFISEATPPVGIQAASTES.C.D.KQLDLVLCRTYEAAASALQIATHTAFVVKALQADISQV.AQILSSDPS.HMH.QAL..G.ILSK.TY.DAASFLCEAAFDEVKMAAHSMGSSTLGRRYLWLKDCKINPASKNKLVVTPFKGGTLFGGEVCKVTKKRGNK.........
G3QLH5_GORGO/461-693               ...................................................................AKTVVSHSLTTLGLEVAK.QSQHDKIDASEL...SFPFHESILKVIEEEWQQVDRQLP...S...LA...C....KYPVSSREATQILSVPKVDDEILGFISEATPLAGIQAASTES.C.N.QQLDLALCRAYEAAASALQIATHTAFVAKAMQADISQA.AQILSSDPS.RTH.QAL..G.ILSK.TY.DAASYICEAAFDEVKMAAHTMGNSTVGRRYLWLKDCKINLASKNKLASTPFKGGTLFGGEVCKVIKKRGNK.........
M7APM7_CHEMY/12-213                rialpliktiqsnyktiwqtpassapmakgverkyfapskgyvflfchpspcslvvsavderewhgq------------------.------------...------------------------...-...--...-....-----------------------------------QATAPKAkE.A.KCLDLFGRKVYSSGGLQLRIANHQATLNRHNFSSWAAV.GKFKDNLPQ.GSQ.QQF.tA.LVDK.GK.TVAKTSLQASLDSADMVARTVTSGVVMRCSVWLQESGLPPKVQNTLQDLPFKGSGLFSD------------qtdmr....
M7BZD3_CHEMY/118-344               ..................................................vafnlglqaeeleepsd------------------.-SLFDILCASAParvALLIHEGVSKITNALWQTPSSLAPiskR...AE...C....KYFMPTKGHEYLYSHPAPNSLVVQVINHKERQGQLRATPKNK.D.S.RWLDLFGRKIYLSSSLQLRVANHQALLGQY-DFNMWQAmAKFEGSLPE.ASK.KEF..RaILNE.GT.NAARAALQVASDVADAAACTMASAISMQQASWLLLSGLSTEAQQSMQDLCFD-------------------gwataasg.
K7F182_PELSI/104-332               ............................................vqlseaqvkqhkllknlhpqqrc------------------.----------RI...ALPSDEAIMDMAHEIWQTPTSIPP...Ts.kRA...D....KYFVPSKDMGFLFNHPQPNSLIVDAARHKNKTSQFRSSLPDK.G.T.RKLDLFGCKMYSSSTLMLRIANYAALLSNHNFDNYAKL.PELMQHLPE.AKR.PLL..KaIVQE.GY.TAWRTLLQIALDVTDTAARAMATGIAMRRASWLMASGAPKELQNKVEDLPFDRKRLFAASTDDV-------lhsgk....
G7PJ42_MACFA/370-602               ...................................................................AKTVVSHSLTTLGLEVSK.QSQHDKIDASEL...SFPFHESILKVIEEEWQQVDRQLP...S...LA...C....RYPVSSKEATRLLSVPKVDDEILGFISEATPPAGIQATSTES.C.D.KQLDLALCRAYEAAASALQIATHTAFVAKAMQADISQA.AQILSSDPS.RTH.QAL..G.ILSK.TY.DAASYICEAAFDEVKMAAHTMGNSTVGRRYLWLKDCKINLASKSKLASTPFKGGTLFGGEVCKVIKKRGNK.........
G5B2K7_HETGA/366-597               ...................................................................AKTVISESLTTLGIEMST.QSQHDKIDASEL...SFPFHESILKVIEEEWQQIDRQLP...S...LA...C....KYPVSSREATRILSVPKVDDEILGFISEATPPAGVQPASTES.C.N.KHLDIALCRTYEAAASALQIATHSAFVAKATQADISQA.AQILSSDPD.RIP.QAL..E.ILSK.AY.DAASFLCEAAFDEVKMASRTMASSTVGRRHLWLKDCKLSPASKNKLTVAPFKGGTLFG-EVHKIIKKRGNK.........
M7AVU9_CHEMY/106-318               ......................................krvansqetalhevqekqhkllkilqpas------------------.--------SAKI...TFPMDESITEPAEAIWQTPASAPP...TnkrAD...R....KYFVPAKGMEFLFSHPQACSLVVEAANQRSKQPHFCCTPQDK.E.H.KRLDLFGCKVYSSATVLLRVANYSALLANYDYSNYSKL.QKLVEDLPK.HKRpQLS..A.VVNE.GQ.IIACTALQASMDVADTAARTVATAVVMRRTSWLQA------------------------------------sverttaks
L9LCW4_TUPCH/532-764               ...................................................................AKTVVLHSLTTLGIEMSK.DSQHNRIGTSEL...SFPFHESILKVIEEEWQQIDRQLP...S...LA...C....KYPISSKEATRILSVPKVDDEIQGFISETTLPAGIQAASTES.C.D.KQLNLALCRSYEAAASALQIATHMAFVAKAMQADISQA.AQILSSDPS.RMH.QAL..G.TLSK.TY.DAASFLCEAAFDEVKMAAHSMGSSTLGLRYLSLKECKINPALKTKLAVTPFRGGTLFGGEVCKVVKKRGNK.........
LAP2A_MOUSE/459-692                ...................................................................AKSVVSHSLTTLGVEVSKpPPQHDKIEASEP...SFPLHESILKVVEEEWQQIDRQLP...S...VA...C....RYPVSSIEAARILSVPKVDDEILGFISEATPRAATQASSTES.C.D.KHLDLALCRSYEAAASALQIAAHTAFVAKSLQADISQA.AQIINSDPS.DAQ.QAL..R.ILNR.TY.DAASYLCDAAFDEVRMSACAMGSSTMGRRYLWLKDCKISPASKNKLTVAPFKGGTLFGGEVHKVIKKRGNK.........
#=GR LAP2A_MOUSE/459-692     SS    ...................................................................XXXXXX-----SSXXXXXXXXXXXXXXXXXX...XXBHHHHHHHHHHHHCCGSSS---...-...-T...T....TS--B-HHHHHHHS--B--HHHHHCCHHTS---STT---THH.H.H.HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH.HHHHHS-TT.-HH.HHH..H.HHHH.HH.HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTS-S-HHHHHHHHHS---SSBSSTTTCGGTS---XXX.........
G9KUB8_MUSPF/410-507               ...................................................................AKTVVSHSLTTLGIEVSK.QSQHENTDAPEL...SFPFHESILKVIEEEWQQIDKQLP...S...LA...C....KYPISSREATQILSVPKVDDEILEFISEATPPVGIQAAST--.-.-.--------------------------------------.---------.---.---..-.----.--.-----------------------------------------------------------------------.........
M7BLD8_CHEMY/1427-1527             ............................................lsalqgnlstgwkisgrdhlnis------------------.------------...------------------------...-...--...-....------------------------------------------.-.-.--------------------------------------.---------.---.---..F.ILKR.VS.LATTFIANESIDAMRFTARAMNSSSVTRCPIWLQPWKADLHSKQVLCSAKSTGSLLFGEKLYKLA------adnvak...
U3DHN1_CALJA/461-690               ...................................................................AKTVISHSLTTLGLDMCK.QSQHDKIDASEL...SFPFHESILKVIEEEWQQVDRQLP...S...LA...C....KYPVSSREATRIISVPKVDDEILEFISEATPPAGIQAASTES.C.D.KQLDLALCRAYEAAASALQIATHTAFVAKAVQADISQA.AQILSSD--.-TH.QAL..G.ILSK.TY.DAASYICEAAFDEVKMAAHTMGNSTVGRRYLWLKDCKINLASKNKLAATPFKGGTLFGGEVYKVIKKRGNK.........
L8I1S6_9CETA/456-688               ...................................................................AKTVVSHSLATLGIEMSE.QSQHDKIDAPEL...SFPFHESILKVIEEEWQQIDRQPP...S...LA...C....RYPVSSREATRILSVPKVDDEILEFISHAAPPASIQAASTES.C.D.KQLDLALCRTYEAAASALQVATHTAFVARALQADVSQA.AQILSSDPS.CTN.QAV..G.LLSR.AY.DAASFLCEAAFDEVKMAAHTMGSSTLGRRHLWLKDCRINPASKNKLAVVPFKGGTLFGREVLKVIKKYGNK.........
U3FW61_CALJA/345-498               ......................................................egpivealehskr------------------.------------...------------------------...-...--...-....---------------------------------GNTTSPLDS.T.S.KEMEVMGCRFYHAASIAARAASYMAYMTQ-YQRKLWED.MEDLVHDPEfDRG.KAR..C.IISD.GM.DAGLWQLCTTRDIMDSVVRVMAMAIDYRRQAWLRLTSLTKKTQEKISHLPFDGTSLFGQDVKAVVA-----eess.....
Q8VCL4_MOUSE/343-497               .....................................................aegpiidvlehskr------------------.------------...------------------------...-...--...-....---------------------------------GNTASPLDS.T.S.KEMEVMGCRFYHAASIAARAASYMAYMTQ-YQRKLWED.MEDLVHDPEfDRG.KAR..C.IISD.GM.DAGLWQLCTTRDIMDSVVRVMAMAVDYRRQAWLRLTSLTKKTQEKILHLPFDGTSLFGQDVNAIVA-----edns.....
LAP2A_HUMAN/461-693                ...................................................................AKTVVSHSLTTLGLEVAK.QSQHDKIDASEL...SFPFHESILKVIEEEWQQVDRQLP...S...LA...C....KYPVSSREATQILSVPKVDDEILGFISEATPLGGIQAASTES.C.N.QQLDLALCRAYEAAASALQIATHTAFVAKAMQADISQA.AQILSSDPS.RTH.QAL..G.ILSK.TY.DAASYICEAAFDEVKMAAHTMGNATVGRRYLWLKDCKINLASKNKLASTPFKGGTLFGGEVCKVIKKRGNK.........
Q9CUK0_MOUSE/343-497               .....................................................aegpiidvlehskr------------------.------------...------------------------...-...--...-....---------------------------------GNTASPLDS.T.S.KEMEVMGCRFYHAASIAARAASYMAYMTQ-YQRKLWED.MEDLVHDPEfDRG.KAR..C.IISD.GM.DAGLWQLCTTRDIMDSVVRVMAMAVDYRRQAWLRLTSLTKKTQEKILHLPFDGTSLFGQDVNAIVA-----edns.....
H0VJK1_CAVPO/323-555               ...................................................................AKTVVSHSLSTLGIEMSN.QSQHDKLDASGL...SFPLHESILKVIEEEWQQVDRELP...S...LA...C....KYPVSSREATRILSVPKVDDEILGLIAEGTPAAGVQPASAES.C.D.KHLDLALCRTYEAAASVLQAATHTAFVAKAMQADISQA.AQILSADPS.HAP.QAL..E.MLSR.TY.DAASFLCEAAFDEVKMAACTMASSSGGRRHLWLKDCRLSPASKNKLTVAPFKGGTLFGGEVHKIIKKRGNK.........
M7B7Z8_CHEMY/12-161                ..................................................vkqkkkhqfprstpsdk------------------.------------...------------------------...-...--...-....------------------------------------------.D.S.RQLDLLGRKVYASSTLQFRIATYSAVLAKYDHKNYNKF.MDFIDHIPE.DKK.QQI.tA.IVSE.GQ.ILSRTALQAALDVANIAARSTATAVVMRRGSWLSSSSFPRKFQSTIEDLPFDGDKLFASTTNDVL------hsmkd....
S9Y6N0_9CETA/343-575               ...................................................................AKTVVSHSLTTLGIEMSM.QSQHDKIDAPEL...SFPFHESILKVIEEEWQQIDKQLP...S...LA...C....KYPISSREATRILSVPKVDDEILGLITDASPPTGIQAVSNES.C.D.KQLDLALCRTYEAAASALQVATHTAFVVRAMQADISQA.AQILSSEPS.RTH.QAL..G.MLSK.TY.DAALFLCEAAFDEVKMAAHTMGSSTLGRRYLWLKDCKINPASKNKLAVVPFKGGMLLGREGLKIIKKRGNK.........
L5KIK6_PTEAL/460-688               ...................................................................AKTVISHSLATLGIEMSK.QSQHDKIDAPEL...SFPFHESMSKVIEEEWQQIDRQLP...S...LA...C....KYPVSSEEATQILSVPKVDDEILGFISEATTPSGIQAAST--.-.S.KQLDLALCRAYEAAASTLQIATHTAFVVRAMQAEISQA.AQILSSDPS.HMQ.QAL..G.ILSK.TY.DAASFLCEAAFDEVKMAARIMGSSTLGRRYLWLKDCKINPASKNKLAVIPFKGGTLFGGEVGNVVKKH---sk.......
F6YNY7_CALJA/461-690               ...................................................................AKTVISHSLTTLGLDMCK.QSQHDKIDASEL...SFPFHESILKVIEEEWQQVDRQLP...S...LA...C....KYPVSSREATRILSVPKVDDEILEFISEATPPAGIQAASTES.C.D.KQLDLALCRAYEAAASALQIATHTAFVAKAVQADISQA.AQILSSD--.-TH.QAL..G.ILSK.TY.DAASYICEAAFDEVKMAAHTMGNSTVGRRYLWLKDCKINLASKNKLAATPFKGGTLFGGEVYKVIKKRGNK.........
G3I2N4_CRIGR/90-318                ............................................................drysdnd-----------EGIEMSE.QPQHDKIDASEP...SFPLHDSILKVIEEEWQQTDRQLP...S...LA...C....KYPVSSSEATRILSVPAVDDEILGLVSETTPRAAIQASSTES.C.D.KHLDLALCRSYEAAASALQIAAHTAFVAKSLQANISQA.AQAISADPS.RAP.QAL..E.ILSR.SY.DAASYLCDAAFDEVRMSAYAMGSSTVGRRHLWLKDCKINPASKNKLTVAPFKGGTLFGGDIHKVIKRRGNK.........
S9XDH7_9CETA/281-434               .......................................................ggpivealahsr------------------.------------...------------------------...-...--...-....--------------------------------RGSAVSPLDS.A.S.KEMEVMGCRFYHAASIAARAASYMAYMTQ-YQRKLWED.MEDLVHDPEfDRG.KAR..C.IISD.GM.DAGLWQLCTTRDIMDSVVRVMAMAIDYRRQAWLRLTSLTKKTQEKISHLPFDGTSLFGQDVNAVVA-----eens.....
I3MD17_SPETR/459-691               ...................................................................AKTVVSHALTTLGMEKSE.KSQHDNIDSSEL...SFPFHESILKVIEEEWQQIDRQLP...S...LA...R....KYPISSREATQILSVPKVDDEIQGFISETIPPAGIQEGSAES.C.D.KHLDLTLCRAYTAAASTMQIATHTAFVVKAMQADISQA.AQIISSDPS.RTH.QAL..N.ILSK.TY.DAASFLCEAAFDEVKMAAYTMGSSTLGRRYLWLKDCKINPASKNKLTVTPFKGGTLFGGEVHKVIKKRGKK.........
K7C541_PANTR/461-693               ...................................................................AKTVVSHSLTTLGLEVAK.QSQHDKIHASEL...SFPFHESILKVIEEEWQQVDRQLP...S...LA...C....KYPVSSREATQILSVPKVDDEILGFISEATPLGGIQAASTES.C.N.QQLDLALCRAYEAAASALQIATHTAFVAKAMQADISQA.AQILSSDPS.RTH.QAL..G.ILSK.TY.DAASYICEAAFDEVKMAAHTMGNSTVGRRYLWLKDCKINLASKNKLASTPFKGGTLFGGEVCKVIKKRGNK.........
M7AIL8_CHEMY/3187-3415             ...............................................................reas-----SLSLQAEEVEEPS.DSLFDVLSATALarvALPLHEGVVKISNALWQIL-SSLP...P...IS...KraerKYFVPAKGHEYL--YPHPNSLVVKVVNHKEHQGQPAPTPKNK.D.S.RRLDLFGQKLYSSSRFQLRVANHQALLGRYDFNSMPKF.TFALQEHNR.KEY.KAL..-.-VED.GT.AAVRAALQAASDAVDMAARTMASAVSMRRTLWLLLSGLSSEGQSSLQDLPFDDKALFSE------------qtdmklh..
#=GC SS_cons                       ...................................................................XXXXXX-----SSXXXXXXXXXXXXXXXXXX...XXBHHHHHHHHHHHHCCGSSS---...-...-T...T....TS--B-HHHHHHHS--B--HHHHHCCHHTS---STT---THH.H.H.HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH.HHHHHS-TT.-HH.HHH..H.HHHH.HH.HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTS-S-HHHHHHHHHS---SSBSSTTTCGGTS---XXX.........
#=GC seq_cons                      ..............................................................................................t.t....uhPhcEulhchhpt.WQp.sp..P...s...ht...p....+Y.lsutttt.lhohPtsss.llthhsctt..sGhpuuus-S.s.s.KpLDLhhCRsYcAAu.ALplAoapAals+hhQsclups.sphLssDPp.cpp.QAh..s.ILSc.sh.DAApahhpAAhDtschAA+oMususshRRhlWL+tspls.topsKLsshPFcGsoLFGt-Vttllt..............
//
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