GenomeNet

Database: Pfam
Entry: LAP2alpha
LinkDB: LAP2alpha
Original site: LAP2alpha 
#=GF ID   LAP2alpha
#=GF AC   PF11560.3
#=GF DE   Lamina-associated polypeptide 2 alpha
#=GF AU   Pollington J
#=GF SE   pdb_2v0x
#=GF GA   25.00 25.00;
#=GF TC   31.50 30.70;
#=GF NC   21.90 19.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   17562312
#=GF RT   Structural basis for dimerization of LAP2alpha, a component of
#=GF RT   the nuclear lamina. 
#=GF RA   Bradley CM, Jones S, Huang Y, Suzuki Y, Kvaratskhelia M, Hickman
#=GF RA   AB, Craigie R, Dyda F; 
#=GF RL   Structure. 2007;15:643-653.
#=GF DR   INTERPRO; IPR021623;
#=GF CC   LAPs are components of the nuclear lamina which supports the
#=GF CC   nuclear envelope.LAP2alpha is a non-membrane-associated member
#=GF CC   of the LAP family which is unique. This family of proteins is
#=GF CC   the C terminal domain of LAP2alpha which consists of residues
#=GF CC   459-693 and constitutes a dimeric structure with an antiparallel
#=GF CC   coiled coil. LAP2alpha is involved in cell-cycle regulation and
#=GF CC   chromatin organisation and preferentially binds to lamin A/C
#=GF CC   [1].
#=GF SQ   25
#=GS F7EUI0_MONDO/446-674  AC F7EUI0.1
#=GS G1R1Z5_NOMLE/461-694  AC G1R1Z5.1
#=GS G9KUB8_MUSPF/410-507  AC G9KUB8.1
#=GS LAP2A_MOUSE/459-693   AC Q61033.4
#=GS LAP2A_MOUSE/459-693   DR PDB; 2V0X A; 465-685;
#=GS LAP2A_MOUSE/459-693   DR PDB; 2V0X B; 465-689;
#=GS Q80TA4_MOUSE/349-504  AC Q80TA4.1
#=GS F6YNY7_CALJA/461-691  AC F6YNY7.1
#=GS G7N578_MACMU/370-603  AC G7N578.1
#=GS F1PUP5_CANFA/348-504  AC F1PUP5.1
#=GS H0VJK1_CAVPO/323-555  AC H0VJK1.1
#=GS D2HE43_AILME/462-694  AC D2HE43.1
#=GS D3ZNL2_RAT/459-692    AC D3ZNL2.1
#=GS F6YF13_MACMU/345-500  AC F6YF13.1
#=GS G1LW26_AILME/460-692  AC G1LW26.1
#=GS LAP2A_HUMAN/461-694   AC P42166.2
#=GS G7PJ42_MACFA/370-603  AC G7PJ42.1
#=GS Q8VCL4_MOUSE/344-499  AC Q8VCL4.1
#=GS F7HAU0_MACMU/462-695  AC F7HAU0.1
#=GS H0X6F2_OTOGA/458-691  AC H0X6F2.1
#=GS D3ZC75_RAT/340-494    AC D3ZC75.1
#=GS G3I2N4_CRIGR/91-319   AC G3I2N4.1
#=GS Q9CUK0_MOUSE/344-499  AC Q9CUK0.3
#=GS E2R4J6_CANFA/460-693  AC E2R4J6.1
#=GS G5B2K7_HETGA/366-598  AC G5B2K7.1
#=GS G3TD04_LOXAF/460-693  AC G3TD04.1
#=GS G3QLH5_GORGO/461-694  AC G3QLH5.1
F7EUI0_MONDO/446-674             ..............AKTVISQSLSTLGIETPK-ECQHDTIRSPEPSFPLHESILKIIDEEWSHIDRQIPSVASKYPVSSRETSHIFSVPKVDNEILELTSQVTPP-----ASTEACNKQLDLALCRTYEAAAGALQIAAHTAFVARAVQTDIGQVAHIISSDPS.RIPEVLGTLSKTYDAASFLCDAAFDEVRMAACTMGSSTMGRRHLWLNNDKVSDTQKNKLSVLPFKGGTLFGGEVQKVIKKRGKRQ......
G1R1Z5_NOMLE/461-694             ..............AKTVVSDSLTTLGLEVSK-QSQRDKTDASELSFPFHESVLKVIEEEWQQVNRQLPSLACKYPVSSREATQILSVPKVDDEILGFISEATPLAGIQAASTESCDQQLDLAFCRAYEAAASALQIATHTAFVAKAMQADISQAAQILSSDPS.RTHQALGILSKTYDAASYICEAAFDEVKMAAHTMGNSTVGRRYLWLKDCKINLASKNKLASTPFKGGTLFGGEVCKVIKKRGNKH......
G9KUB8_MUSPF/410-507             ..............AKTVVSHSLTTLGIEVSK-QSQHENTDAPELSFPFHESILKVIEEEWQQIDKQLPSLACKYPISSREATQILSVPKVDDEILEFISEATPPVGIQAAST---------------------------------------------------.-------------------------------------------------------------------------------------......
LAP2A_MOUSE/459-693              ..............AKSVVSHSLTTLGVEVSKPPPQHDKIEASEPSFPLHESILKVVEEEWQQIDRQLPSVACRYPVSSIEAARILSVPKVDDEILGFISEATPRAATQASSTESCDKHLDLALCRSYEAAASALQIAAHTAFVAKSLQADISQAAQIINSDPS.DAQQALRILNRTYDAASYLCDAAFDEVRMSACAMGSSTMGRRYLWLKDCKISPASKNKLTVAPFKGGTLFGGEVHKVIKKRGNKQ......
#=GR LAP2A_MOUSE/459-693   SS    ..............XXXXXX-----SSXXXXXXXXXXXXXXXXXXXXBHHHHHHHHHHHHCCGSSS-----TTTS--B-HHHHHHHS--B--HHHHHCCHHTS---STT---THHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHS-TT.-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTS-S-HHHHHHHHHS---SSBSSTTTCGGTS---XXXX......
Q80TA4_MOUSE/349-504             .egpiidvlehskr--------------------------------------------------------------------------------------------GNTASPLDSTSKEMEVMGCRFYHAASIAARAASYMAYMTQY-QRKLWEDMEDLVHDPEfDRGKARCIISDGMDAGLWQLCTTRDIMDSVVRVMAMAVDYRRQAWLRLTSLTKKTQEKILHLPFDGTSLFGQDVNAIVA------ednsik
F6YNY7_CALJA/461-691             ..............AKTVISHSLTTLGLDMCK-QSQHDKIDASELSFPFHESILKVIEEEWQQVDRQLPSLACKYPVSSREATRILSVPKVDDEILEFISEATPPAGIQAASTESCDKQLDLALCRAYEAAASALQIATHTAFVAKAVQADISQAAQILSSD--.-THQALGILSKTYDAASYICEAAFDEVKMAAHTMGNSTVGRRYLWLKDCKINLASKNKLAATPFKGGTLFGGEVYKVIKKRGNKH......
G7N578_MACMU/370-603             ..............AKTVVSHSLTTLGLEVSK-QSQHDKIDASELSFPFHESILKVIEEEWQQVDRQLPSLACRYPVSSKEATRLLSVPKVDDEILGFISEATPPAGIQATSTESCDKQLDLALCRAYEAAASALQIATHTAFVAKAMQADISQAAQILSSDPS.RTHQALGILSKTYDAASYICEAAFDEVKMAAHTMGNSTVGRRYLWLKDCKINLASKSKLASTPFKGGTLFGGEVCKVIKKRGNKH......
F1PUP5_CANFA/348-504             aegpivealehskr--------------------------------------------------------------------------------------------GSTTSPLDSTSKEMEVMGCRFYHAASIAARAASYMAYMTQY-QRKLWEDMEDLVHDPEfDRGKARCIISDGMDAGLWQLCTTRDIMDSVVRVMAMAIDYRRQAWLRLTSLTKKTQEKISHLPFDGTSLFGQDVNAVVA------eensik
H0VJK1_CAVPO/323-555             ..............AKTVVSHSLSTLGIEMSN-QSQHDKLDASGLSFPLHESILKVIEEEWQQVDRELPSLACKYPVSSREATRILSVPKVDDEILGLIAEGTPAAGVQPASAESCDKHLDLALCRTYEAAASVLQAATHTAFVAKAMQADISQAAQILSADPS.HAPQALEMLSRTYDAASFLCEAAFDEVKMAACTMASSSGGRRHLWLKDCRLSPASKNKLTVAPFKGGTLFGGEVHKIIKKRGNK-......
D2HE43_AILME/462-694             ..............AKTVVSHSLTTLGIEMSK-QSQHEKIDASELSFPFHESILKVIEEEWQQIDRQLPSLACKYPISSREATQILSVPKVDDEILEFISEATPPVGIQAASTESCDKQLDLVLCRTYEAAASALQIATHTAFVVKALQADISQVAQILSSDPS.HMHQALGILSKTYDAASFLCEAAFDEVKMAAHSMGSSTLGRRYLWLKDCKINPASKNKLVVTPFKGGTLFGGEVCKVTKKRGNK-......
D3ZNL2_RAT/459-692               .............g-KSVVSHSLTTLGIEVSE-QPRRDKIDASEPSFPLHESIVKVIEEEWQQIDRQLPMVACKYPVSSSEATRILSVPKVDDEILGFISEATPRAATQASSTESCDKQLDLALCRSYEAAASALQIAAHTAFVAKSLQADISQAAQMINSDPN.DALQALEILSRAYDAASYLCDAAFDEARMCACTMGSSTMGRRYLWLKDCKISPASKNKLTVAPFKGGALFGGEVHKVIKKRGNKQ......
F6YF13_MACMU/345-500             .egpivealehskr--------------------------------------------------------------------------------------------GNTTSPLDSTSKEMEVMGCRFYHAASIAARAASYMAYMTQY-QRKLWEDMEDLVHDPEfDRGKARCIISDGMDAGLWQLCTTRDIMDSVVRVMAMAIDYRRQAWLRLTSLTKKTQEKISHLPFDGTSLFGQDVKAVVA------eensik
G1LW26_AILME/460-692             ..............AKTVVSHSLTTLGIEMSK-QSQHEKIDASELSFPFHESILKVIEEEWQQIDRQLPSLACKYPISSREATQILSVPKVDDEILEFISEATPPVGIQAASTESCDKQLDLVLCRTYEAAASALQIATHTAFVVKALQADISQVAQILSSDPS.HMHQALGILSKTYDAASFLCEAAFDEVKMAAHSMGSSTLGRRYLWLKDCKINPASKNKLVVTPFKGGTLFGGEVCKVTKKRGNK-......
LAP2A_HUMAN/461-694              ..............AKTVVSHSLTTLGLEVAK-QSQHDKIDASELSFPFHESILKVIEEEWQQVDRQLPSLACKYPVSSREATQILSVPKVDDEILGFISEATPLGGIQAASTESCNQQLDLALCRAYEAAASALQIATHTAFVAKAMQADISQAAQILSSDPS.RTHQALGILSKTYDAASYICEAAFDEVKMAAHTMGNATVGRRYLWLKDCKINLASKNKLASTPFKGGTLFGGEVCKVIKKRGNKH......
G7PJ42_MACFA/370-603             ..............AKTVVSHSLTTLGLEVSK-QSQHDKIDASELSFPFHESILKVIEEEWQQVDRQLPSLACRYPVSSKEATRLLSVPKVDDEILGFISEATPPAGIQATSTESCDKQLDLALCRAYEAAASALQIATHTAFVAKAMQADISQAAQILSSDPS.RTHQALGILSKTYDAASYICEAAFDEVKMAAHTMGNSTVGRRYLWLKDCKINLASKSKLASTPFKGGTLFGGEVCKVIKKRGNKH......
Q8VCL4_MOUSE/344-499             .egpiidvlehskr--------------------------------------------------------------------------------------------GNTASPLDSTSKEMEVMGCRFYHAASIAARAASYMAYMTQY-QRKLWEDMEDLVHDPEfDRGKARCIISDGMDAGLWQLCTTRDIMDSVVRVMAMAVDYRRQAWLRLTSLTKKTQEKILHLPFDGTSLFGQDVNAIVA------ednsik
F7HAU0_MACMU/462-695             ..............AKTVVSHSLTTLGLEVSK-QSQHDKIDASELSFPFHESILKVIEEEWQQVDRQLPSLACRYPVSSKEATRLLSVPKVDDEILGFISEATPPAGIQATSTESCDKQLDLALCRAYEAAASALQIATHTAFVAKAMQADISQAAQILSSDPS.RTHQALGILSKTYDAASYICEAAFDEVKMAAHTMGNSTVGRRYLWLKDCKINLASKSKLASTPFKGGTLFGGEVCKVIKKRGNKH......
H0X6F2_OTOGA/458-691             ..............AKSVVSHSLTTLGIEMSK-ESQYDKIHASEPSFPLHESILKVIEEEWQQIDRQLPSLACKYPISSGEATRILSVPKVDDEILGFISEATPPASIQAATTESCDKQLDLALCRAYEAAASALQIATHTAFVAKAMQADISQAARILSSDPS.RMQQALGILSKTYDAASYICDAAFDEVKISAHTMGNSTVGRRHLWLKECKLNSASKNKLAVTSFKGGTLFGGEVYKVIKKRGNKH......
D3ZC75_RAT/340-494               gpiidvlehskrgn----------------------------------------------------------------------------------------------TTSPLDSTSKEMEVMGCRFYHAASIAARAASYMAYMTQY-QRKLWEDMEDLVHDPEfDRGKARCIISDGMDAGLWQLCTTRDIMDSVVRVMAMAVDYRRQAWLRLTSLTKKTQEKILHLPFDGTSLFGQDVNAIVA------ednsik
G3I2N4_CRIGR/91-319              ........rysdnd-----------EGIEMSE-QPQHDKIDASEPSFPLHDSILKVIEEEWQQTDRQLPSLACKYPVSSSEATRILSVPAVDDEILGLVSETTPRAAIQASSTESCDKHLDLALCRSYEAAASALQIAAHTAFVAKSLQANISQAAQAISADPS.RAPQALEILSRSYDAASYLCDAAFDEVRMSAYAMGSSTVGRRHLWLKDCKINPASKNKLTVAPFKGGTLFGGDIHKVIKRRGNKQ......
Q9CUK0_MOUSE/344-499             .egpiidvlehskr--------------------------------------------------------------------------------------------GNTASPLDSTSKEMEVMGCRFYHAASIAARAASYMAYMTQY-QRKLWEDMEDLVHDPEfDRGKARCIISDGMDAGLWQLCTTRDIMDSVVRVMAMAVDYRRQAWLRLTSLTKKTQEKILHLPFDGTSLFGQDVNAIVA------ednsik
E2R4J6_CANFA/460-693             ..............AKTVVSHSLTTLGMEVSK-QSQHEKVDAPELSFPFHESILKVIEEEWQQIDRQLPSLACKYPVSSREATRILSVPKVDDEILEFISEATPPVGTQAASTESCDKQLDLVLCRTYEAAASALQIATHTAFVVRALQADISQAAQILSSDPS.HMHQALGILSKTYDAASFLCEAAFDEVKMAAHSMGASTLGRRYLCLKDCKINPASKNKLVVTPFKGETLFGGEVYKVTKKRGNKR......
G5B2K7_HETGA/366-598             ..............AKTVISESLTTLGIEMST-QSQHDKIDASELSFPFHESILKVIEEEWQQIDRQLPSLACKYPVSSREATRILSVPKVDDEILGFISEATPPAGVQPASTESCNKHLDIALCRTYEAAASALQIATHSAFVAKATQADISQAAQILSSDPD.RIPQALEILSKAYDAASFLCEAAFDEVKMASRTMASSTVGRRHLWLKDCKLSPASKNKLTVAPFKGGTLFG-EVHKIIKKRGNKH......
G3TD04_LOXAF/460-693             ..............AKTVVSNSLTTLGIEMSK-QSQHDKIDDYELSFPLHESILKVIEEEWQQIDRQRPSLACKYPVSSREAPRILSVPKVDDEILGFLSEGSPPAGIQAASSEACDKQLDLALCRTYEAAASALQIATHAAFVVRAMQADISQAAQILSSDPT.QMHQALRILSKTYDAASYLCEAAFDEVKMAAHTMGSSSVGRRYLWLKDCKINPASKNKLAVTPFKGGTLFGGEVCKIIKKRGNK-n.....
G3QLH5_GORGO/461-694             ..............AKTVVSHSLTTLGLEVAK-QSQHDKIDASELSFPFHESILKVIEEEWQQVDRQLPSLACKYPVSSREATQILSVPKVDDEILGFISEATPLAGIQAASTESCNQQLDLALCRAYEAAASALQIATHTAFVAKAMQADISQAAQILSSDPS.RTHQALGILSKTYDAASYICEAAFDEVKMAAHTMGNSTVGRRYLWLKDCKINLASKNKLASTPFKGGTLFGGEVCKVIKKRGNKH......
#=GC SS_cons                     ..............XXXXXX-----SSXXXXXXXXXXXXXXXXXXXXBHHHHHHHHHHHHCCGSSS-----TTTS--B-HHHHHHHS--B--HHHHHCCHHTS---STT---THHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHS-TT.-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTS-S-HHHHHHHHHS---SSBSSTTTCGGTS---XXXX......
#=GC seq_cons                    ..............AKTVVScSLTTLGlEhSK.QSQHDKIDASE.SFPhHESILKVIEEEWQQlDRQLPSLACKYPVSS+EATpILSVPKVDDEILtFISEATP.sGlQAuSTESCsKpLDLALCRsYEAAASALQIAoHTAFVsKAhQADISQAAQILSSDPo.cttQALsILS+TYDAASalC-AAFDEV+MuA+oMGsSTsGRRaLWLKDCKls.ASKNKLsssPFKGGTLFGGEVpKVIKKRGNK.......
//
DBGET integrated database retrieval system