#=GF ID LmjF365940-deam
#=GF AC PF14421.1
#=GF DE A distinct subfamily of CDD/CDA-like deaminases
#=GF PI CDD_CDA_1;
#=GF AU Iyer LM, Zhang D, Aravind L
#=GF SE Manual
#=GF GA 45.70 45.70;
#=GF TC 134.30 59.00;
#=GF NC 32.40 23.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 21890906
#=GF RT Evolution of the deaminase fold and multiple origins of
#=GF RT eukaryotic editing and mutagenic nucleic acid deaminases from
#=GF RT bacterial toxin systems.
#=GF RA Iyer LM, Zhang D, Rogozin IB, Aravind L;
#=GF RL Nucleic Acids Res. 2011; [Epub ahead of print]
#=GF CC A distinct branch of the CDD/CDA-like deaminases prototyped by
#=GF CC Leishmania LmjF36.5940. Members of this family are widely
#=GF CC distributed across several microbial eukaryotes such as
#=GF CC kinetoplastids, chlorophyte algae, stramenopiles and the
#=GF CC alveolate Perkinsus. Domain architectures suggest that these
#=GF CC proteins might possess mRNA editing or DNA mutagenizing
#=GF CC activity [1].
#=GF SQ 36
#=GS C5KBD0_PERM5/70-171 AC C5KBD0.1
#=GS Q38A89_TRYB2/370-497 AC Q38A89.1
#=GS G0U7G4_TRYVI/397-470 AC G0U7G4.1
#=GS G0UX70_TRYCI/369-494 AC G0UX70.1
#=GS D0N437_PHYIT/361-620 AC D0N437.1
#=GS F0WBH1_9STRA/347-594 AC F0WBH1.1
#=GS C1EFE8_MICSR/391-596 AC C1EFE8.1
#=GS D7G3E7_ECTSI/557-885 AC D7G3E7.1
#=GS C5KBD0_PERM5/165-215 AC C5KBD0.1
#=GS G0U7G4_TRYVI/277-401 AC G0U7G4.1
#=GS E7LE80_TRYCR/489-561 AC E7LE80.1
#=GS C1N795_MICPC/486-700 AC C1N795.1
#=GS A4HQB2_LEIBR/418-544 AC A4HQB2.1
#=GS E9BUX7_LEIDB/127-253 AC E9BUX7.1
#=GS E7LE80_TRYCR/369-492 AC E7LE80.1
#=GS A4HQB2_LEIBR/540-610 AC A4HQB2.1
#=GS E9AU29_LEIMU/411-537 AC E9AU29.1
#=GS Q4CXE8_TRYCC/489-561 AC Q4CXE8.1
#=GS Q4Q0G6_LEIMA/412-538 AC Q4Q0G6.1
#=GS D0A3Z2_TRYB9/497-569 AC D0A3Z2.1
#=GS G0UX70_TRYCI/490-563 AC G0UX70.1
#=GS D0A3Z2_TRYB9/373-500 AC D0A3Z2.1
#=GS A4IE07_LEIIN/127-253 AC A4IE07.1
#=GS E9BUX7_LEIDB/250-318 AC E9BUX7.1
#=GS A4IE07_LEIIN/250-318 AC A4IE07.1
#=GS Q4CXE8_TRYCC/369-492 AC Q4CXE8.1
#=GS E9AU29_LEIMU/534-602 AC E9AU29.1
#=GS B7GB54_PHATC/685-977 AC B7GB54.1
#=GS Q38A89_TRYB2/494-566 AC Q38A89.1
#=GS Q4DNI7_TRYCC/489-561 AC Q4DNI7.1
#=GS G5AGH2_PHYSP/357-655 AC G5AGH2.1
#=GS C5KHT8_PERM5/164-214 AC C5KHT8.1
#=GS Q4DNI7_TRYCC/369-492 AC Q4DNI7.1
#=GS H3GUA2_PHYRM/361-650 AC H3GUA2.1
#=GS C5KHT8_PERM5/69-170 AC C5KHT8.1
#=GS Q4Q0G6_LEIMA/534-603 AC Q4Q0G6.1
C5KBD0_PERM5/70-171 .pta----VLANKLREYMERTTADG---..FQPEPFFHRKS.GKLVLSMLH..VRME....------DGSDE................................FFEGINGEVSLPTGSLCSERAAIAHARSVHPRINRGMFMGIAVIDV.......------...-----.---.----.-...........---.---...........................................................................----......................................................----.........................................-------.........------.........................--.----------------.....-------------.--.---------ptkmndg
Q38A89_TRYB2/370-497 ..rt--LDLKREGAKSFFTNITLEILQFrsTMADCSWRKKDpMRQVVTSLMtyVDHKk..cHCNVTCGSRRHwsmhkpalssngngm.snatfpdhswctcprsTVMAVNYELSTPSGSRCSEQNALGK-LAS-----------------.......------...-----.---.----.-...........---.---...........................................................................----......................................................----.........................................-------.........------.........................--.----------------.....-------------.--.---------mgl....
G0U7G4_TRYVI/397-470 astg------------------------..-----------.---------..----....-----------................................----------------------------------------------.......------...-----.---.----.-...........---.--L...........................................................................PTTV......................................................VREV.........................................FVYGDSS.........ASKTET.........................NP.LFPCGVCENMLRKVSNdvfrqHGGDVMLYMFDSTtRP.RKLIYLPI-p......
G0UX70_TRYCI/369-494 ..rt--IELRREGRHSFFTHVTPIILNFrkTNAHCSWRKKDpNRPVVTSLItyVDPN....TCRCHVNDGENvwqtsplpvrdadva.edlkfpqrswcscprsYVVAVNYELSTPSGSRCSEQNALGK-LAS-----------------.......------...-----.---.----.-...........---.---...........................................................................----......................................................----.........................................-------.........------.........................--.----------------.....-------------.--.---------kgl....
D0N437_PHYIT/361-620 ...a-LTQMIVREMRKFRDQFLAAEGE-..GEVAGFWLRKS.RKPVLAVLL..IEKP....AAELGGRPTIV................................VQRGMNCEVSMPTGSLCAERNAIGSALASDPTLTRRALKMIAVLGL.......NLTAGG..nSSSVT.SPT.ASEDtG...........DDAkRKEpsqgasfdk.........................................................taststapaE--Lhvveaanpqvlsvrvrpaavqss.......lssaatnnstvaaragrgrgrgrgKREL.........................................ETKNANL.........TSPRKP........................kRPrTFSFDEVAEWLVKIAE.....ANPSFRVVTFENS.RC.RNVYINQIM.......
F0WBH1_9STRA/347-594 ...p-MVQLVVQEMCVFRDQFLKAQGE-..GEVESFWLRKS.RKPVLAVLL..VEKH....--EEDGSVRLL................................VHRGMNCEVSMPTGSLCAERNAIGSALAQDPTLCRRSLKMIAVLGV.......NLQENR...ASVVT.SAT.TVAG.Scgl....npsrT--.--Eaipddihnnlvfnkrlnqpyqlss...........................iratcqmtlsrafecereaghalsPSRP......................................................KRPRtfs..................................iddyTMGETQL.........SKIADR.........................NP.LAPCGACKEWLMKIAE.....ANPSFRVITFENA.DC.HNVYISQIM.......
C1EFE8_MICSR/391-596 ...r-LVTGMVQEMKKHRDVFLSMSHSK..HELGEFWLRKT.QKPVLAVLC..VRRRrdgpDDAAHGDAKPQ................................YFRGVNLEVSMPTGSLCSERNAIGNALASDPALRRKDLFGIAVLSLgkg.digATSGGGv.gGGAMS.RES.SFVNlAql.......aaGN-.GGD...........................................................................DLSL......................................................CRPV.........................................TGGG---.........GGRGDL.........................NP.LKPCGACKEWLLKIAE.....VNPGFKVLMFGDV.SC.DDVYIKNV-s......
D7G3E7_ECTSI/557-885 ....AYTRQAFDAPAG-DANGEAVVGGDtrDDLASFWLRKT.KKPVLAVLL..VQKK....------GGRPQ................................LFRGTNMEVSMPTGSLCAERNVIGSALTSDLSLLRRDIKAVAVLSVahlggppASTATT...AAAVP.IDE.RKEG.Asltg...itavDSG.GGRsgwpgaagmgsavgssl........................................ttscapsplsltpamkvsPKSAllrtetgagaedke..........................rlegvrqvrrktkvV--RsiastpkrgvgsggiaaggwekspltdsgggggggrgdgggGMYSDDQgggggsnhhRHPRTSrssivah..........vppetlcsNP.LKPCGACMEWLKKIAE.....VNPDFKVITFTDS.RC.GGVYIEDV-a......
C5KBD0_PERM5/165-215 .ptk------------------------..-----------.---------..----....-----------................................----------------------------------------------.......------...-----.---.----.-...........---.---...........................................................................----......................................................----.........................................------M.........NDGHTD.........................NP.LWPCGACSEWLKKIQQ.....SVPNFRVLAFDSV.EM.NVIYE----rfl....
G0U7G4_TRYVI/277-401 ...r-IIDLKKEPQDSFFTHITPIILSFssNNTHYSWRKNDpKRPVVTSLI..TYVN....PTECSCRSREYgscrsqlsplrngnwhsestfpkhawctcprmHVIAVNYELSTPSGSRCSEQNALGK-LAS-----------------.......------...-----.---.----.-...........---.---...........................................................................----......................................................----.........................................-------.........------.........................--.----------------.....-------------.--.---------tgl....
E7LE80_TRYCR/489-561 smgl------------------------..-----------.---------..----....-----------................................----------------------------------------------.......------...-----.---.----.-...........---.---...........................................................................PTSA......................................................IREI.........................................FVHGEML.........GSKKDP.........................NP.LFPCGVCENMLRKVTRdvhdaYGGDVVLYMFDSTvNP.KKLVYLPIN.......
C1N795_MICPC/486-700 ...a-IISRMVDEMKKHRDAYVAAASEK.tNELGAFWLRKT.RKPVLAVLC..VRKK...gK---T-GRGHE................................FYRGVNLEVSMPTGSLCSERNVIGTALACDPTLRRADLFGVAVLSL.......KKTGGE..gSGSGN.AQKgGVIN.Gg.........vRDG.GTA...........................................................................PPTP......................................................VPGS.........................................SFAGGAS.........RNASYAndlsglgsgp.....tcrpvaeddlNP.LHPCGACKEWLYKIAE.....VNPGFKVVMFTDA.SC.EEVFVKTV-g......
A4HQB2_LEIBR/418-544 ...n-IIDLKKEHPNSFFSNATRMIQHFcrTRAHCSWRKHDpTRPVVTSVLtfVDVNr..cHCHRNGDNPYNtheehieasfpsdie..amgtpsgawcqcmrrGVIAVNYELSTPSGSRCSEQNAMGK-LAS-----------------.......------...-----.---.----.-...........---.---...........................................................................----......................................................----.........................................-------.........------.........................--.----------------.....-------------.--.---------lgv....
E9BUX7_LEIDB/127-253 ...s-IIDLKKEQPNTFFSNATRMIQSFcrTHAHCSWRKHDpSRPVVTSVLtfVDVNk..cRCHLNGDNPENkheehidapipadie..emgtpsgswcqcmrrGVIAVNYELSTPSGSRCSEQNAMGK-LAS-----------------.......------...-----.---.----.-...........---.---...........................................................................----......................................................----.........................................-------.........------.........................--.----------------.....-------------.--.---------lgv....
E7LE80_TRYCR/369-492 ...n-IVDLRKEPEGSFLSKLCPIIMSFrqKNAHVSWRKKDpNRPVVTSLItyIDPEe..cDCQVDCSGRGRppalikpngrege.....ekhprstwctctrsFVLAVNYELSTPSGSRCSEQNALGK-LAS-----------------.......------...-----.---.----.-...........---.---...........................................................................----......................................................----.........................................-------.........------.........................--.----------------.....-------------.--.---------mgl....
A4HQB2_LEIBR/540-610 aslg------------------------..-----------.---------..----....-----------................................----------------------------------------------.......------...-----.---.----.-...........---.--V...........................................................................PTWG......................................................VREV.........................................FVHGM--.........ASKKEA.........................NP.LFPCGVCENMLQRVTKdvlahYGGDITLYMFDAT.TP.RKIVFLPI-p......
E9AU29_LEIMU/411-537 ...s-IIDLKKEQPDTFFINATRMIQNFcrTHAHCSWRKHDpSRPVVTSVLtfVDVNk..cHCHLNGDNPENtreehidapipadie..amgtpsgswcqcmrrGVIAVNYELSTPSGSRCSEQNAMGK-LAS-----------------.......------...-----.---.----.-...........---.---...........................................................................----......................................................----.........................................-------.........------.........................--.----------------.....-------------.--.---------lgv....
Q4CXE8_TRYCC/489-561 smgl------------------------..-----------.---------..----....-----------................................----------------------------------------------.......------...-----.---.----.-...........---.---...........................................................................PTSA......................................................IREI.........................................FVHGEML.........GSKKDP.........................NP.LFPCGVCENMLRKVTRdvhdtYGGDVVLYMFDSTvNP.KKLVYLPIN.......
Q4Q0G6_LEIMA/412-538 ...t-IIDLKKEQPNTFFSNATRIIQNFcrTHAHCSWRKHNpSRLVVTSVLtfVDVNk..cHCHLNGDNPEDthderidapitadie..amgtpsgswcqcmrgGVIAVNYELSTPSGSRCSEQNAMGK-LAS-----------------.......------...-----.---.----.-...........---.---...........................................................................----......................................................----.........................................-------.........------.........................--.----------------.....-------------.--.---------lgv....
D0A3Z2_TRYB9/497-569 smgl------------------------..-----------.---------..----....-----------................................----------------------------------------------.......------...-----.---.----.-...........---.---...........................................................................PTCA......................................................VREV.........................................FVHGEHQ.........GSKKDP.........................NP.LFPCGVCENMLRKVAHdvleiHGGDVMLYMYDSThNP.KRLVYLPI-t......
G0UX70_TRYCI/490-563 .ask------------------------..-----------.---------..----....-----------................................----------------------------------------------.......------...-----.---.----.-...........---.-GL...........................................................................PTHV......................................................VREV.........................................FVHGENK.........ASQKDP.........................NP.LFPCGVCENMLRKVAHdvfeaHGGDIMLYMYDST.TCpKQLVYLPI-t......
D0A3Z2_TRYB9/373-500 ..rt--LDLKREGAKSFFTNVTLEILQFrsTMADCSWRKKDpMRQVVTSLMtyVDHKk..cHCNVTCGSRRHwsmhksalssngngm.snatfpdhswctcprsTVMAVNYELSTPSGSRCSEQNALGK-LAS-----------------.......------...-----.---.----.-...........---.---...........................................................................----......................................................----.........................................-------.........------.........................--.----------------.....-------------.--.---------mgl....
A4IE07_LEIIN/127-253 ...s-IIDLKKEQPNTFFSNATRMIQSFcrTHAHCSWRKHDpSRPVVTSVLtfVDVNk..cHCHLNGDNPENtheehidapipadie..emgtpsgswcqcmrrGVIAVNYELSTPSGSRCSEQNAMGK-LAS-----------------.......------...-----.---.----.-...........---.---...........................................................................----......................................................----.........................................-------.........------.........................--.----------------.....-------------.--.---------lgv....
E9BUX7_LEIDB/250-318 .slg------------------------..-----------.---------..----....-----------................................----------------------------------------------.......------...-----.---.----.-...........---.--V...........................................................................PTWG......................................................VREV.........................................FVHGR--.........-AAKEP.........................NP.LFPCGVCENMLRRVTKdvlahYGGDVTLYMFDAT.TP.RKIVFLTI-p......
A4IE07_LEIIN/250-318 .slg------------------------..-----------.---------..----....-----------................................----------------------------------------------.......------...-----.---.----.-...........---.--V...........................................................................PTWG......................................................VREV.........................................FVHGR--.........-AAKEP.........................NP.LFPCGVCENMLRRVTKdvlahYGGDVTLYMFDAT.TP.RKIVFLTI-p......
Q4CXE8_TRYCC/369-492 ...n-IVDLRKEPEGSFLSKLCPIIMSFrqKNAHVSWRKKDpNRPVVTSLItyIDPEe..cDCQVDCSGRGRppalmkpngrere.....ekhprstwctctrsFVLAVNYELSTPSGSRCSEQNALGK-LAS-----------------.......------...-----.---.----.-...........---.---...........................................................................----......................................................----.........................................-------.........------.........................--.----------------.....-------------.--.---------mgl....
E9AU29_LEIMU/534-602 .slg------------------------..-----------.---------..----....-----------................................----------------------------------------------.......------...-----.---.----.-...........---.--V...........................................................................PTWG......................................................VREV.........................................FVHGM--.........-AAKEP.........................NP.LFPCGVCENMLRRVTKdvlahYGGDVTLYMFDAT.TP.RKIVFLTI-s......
B7GB54_PHATC/685-977 ...p-YRHLVIDEMKAFQAEMIKTLQGQ..NDIHRFWLRKT.HKPVLAVLL..VEQE....-------GQPI................................LYRGTNMEVSMPTGSLCAERNVIGTALAANPSLRRQDLKMIAVLAVpwqekltDMGSAGtlrSSEEP.FPA.LASSsAsltsimctttlES-.--GegrktsigseheewilssapaggedgstgattnktrlppakselgnsfdlvdsgvpssssgvastapdrqpnddiPSTP......................................................VRRI.........................................ALFSRSG.........TVARKSqqavvl............vqstrdlNP.LPPCGACNEWLKKIAE.....CNPYFCVLTFTDA.EC.HGVYCTPCQ.......
Q38A89_TRYB2/494-566 smgl------------------------..-----------.---------..----....-----------................................----------------------------------------------.......------...-----.---.----.-...........---.---...........................................................................PTCA......................................................VREV.........................................FVHGEHQ.........GSKKDP.........................NP.LFPCGVCENMLRKVAHdvleiHGGDVMLYMYDSThNP.KRLVYLPI-t......
Q4DNI7_TRYCC/489-561 smgl------------------------..-----------.---------..----....-----------................................----------------------------------------------.......------...-----.---.----.-...........---.---...........................................................................PTSA......................................................IREI.........................................FVHGEML.........GSKKDP.........................NP.LFPCGVCENMLRKVTRdvhdaYGGDVVLYMFDSTvNP.KKLVYLPIN.......
G5AGH2_PHYSP/357-655 ...a-MTQMIVREMRIFRDQFLAAEGD-..GEVASFWLRKS.RKPVLAVLL..IEKP....AAVVGDRPTIV................................VQRGMNCEVSMPTGSLCAERNAIGSALASDPTLSRRALKMIAVLGL.......NLTAEG..pSSNVT.SPT.ASETrGseregpatctkD--.--Tkgngngkrd........................................................psdaeatfdkPTSTstepgpelvaqpqpltvrirpageqsspernslslaaasprarshvggagrgrgKRGP.........................................ETKNANL.........TSPRKPkrprtfsmddvavdemlrasgppdrNP.LAPCGACKEWLVKIAE.....ANPSFRVVTFENS.RC.RNVYINQL-m......
C5KHT8_PERM5/164-214 .ptk------------------------..-----------.---------..----....-----------................................----------------------------------------------.......------...-----.---.----.-...........---.---...........................................................................----......................................................----.........................................------M.........NDGHTD.........................NP.LWPCGACSEWLKKIQE.....SVPNFRVLAFDSI.EM.NVIYE----rfl....
Q4DNI7_TRYCC/369-492 ...n-IVDLRKEPEGSFLSKLCPIIMSFrqKNAHVSWRKKDpNRPVVTSLItyIDPEe..cDCQVDCSGRGRppalikpngrere.....ekhprstwcnctrsFVLAVNYELSTPSGSRCSEQNALGK-LAS-----------------.......------...-----.---.----.-...........---.---...........................................................................----......................................................----.........................................-------.........------.........................--.----------------.....-------------.--.---------mgl....
H3GUA2_PHYRM/361-650 ...a-LTQMIVREMRMFRDQFLAAEGE-..GEVASFWLRKS.RKPVLAVLL..IEKP....AAVAGERPTIV................................VQRGMNCEVSMPTGSLCAERNAIGSALASDPTLTRRALKMIAVLGL.......NLSGSG...SNVISpTPS.ETRG.Sereg...gavgDDG.NKKpseaqaaa...........................................................gptfdqptS--Tstagptapalpvrirpacvqsspep....pdankpaerqgsvggvgrgrgrgrgKRAL.........................................ENKNANL.........TSPRKPkrprtfsfdevaveemmrasappdrNP.LAPCGACKEWLVKIAE.....ANPSFRVVTFENS.RC.RNVYINQL-m......
C5KHT8_PERM5/69-170 ptav-----LANKLRDYMERTTADG---..FQPDPFFHRKS.GKLVLSMLH..VRME....------DGRDE................................FFEGINGEVSLPTGSLCSERAAIAHARSVHPRINRGMFMGIAVIDV.......------...-----.---.----.-...........---.---...........................................................................----......................................................----.........................................-------.........------.........................--.----------------.....-------------.--.---------ptkmndg
Q4Q0G6_LEIMA/534-603 aslg------------------------..-----------.---------..----....-----------................................----------------------------------------------.......------...-----.---.----.-...........---.--V...........................................................................PTWG......................................................VREV.........................................FVHGM--.........-AATEP.........................NP.LFPCGVCENMLRRVTKdvlahYGGDVTLYMFDAT.TP.RKIVFLPI-p......
#=GC seq_cons ...s.....hhp..t.....h............t..ah+ps..+.Vls.lh..h..................................................h..uhNhElShPoGShCuEpsshup.hs.........................................................................................................................................................................................................................................................................t...........................pP.h.shs.s.phL.+ltp......ss.hhlhhats..p..t.lh............
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