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Database: Pfam
Entry: LmjF365940-deam
LinkDB: LmjF365940-deam
Original site: LmjF365940-deam 
#=GF ID   LmjF365940-deam
#=GF AC   PF14421.3
#=GF DE   A distinct subfamily of CDD/CDA-like deaminases
#=GF PI   CDD_CDA_1;
#=GF AU   Iyer LM, Zhang D, Aravind L
#=GF SE   Manual
#=GF GA   45.70 45.70;
#=GF TC   69.30 56.80;
#=GF NC   32.60 45.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   21890906
#=GF RT   Evolution of the deaminase fold and multiple origins of
#=GF RT   eukaryotic editing and mutagenic nucleic acid deaminases from
#=GF RT   bacterial toxin systems.
#=GF RA   Iyer LM, Zhang D, Rogozin IB, Aravind L;
#=GF RL   Nucleic Acids Res. 2011; [Epub ahead of print]
#=GF CC   A distinct branch of the CDD/CDA-like deaminases prototyped by 
#=GF CC   Leishmania LmjF36.5940. Members of this family are widely
#=GF CC   distributed across several microbial eukaryotes such as
#=GF CC   kinetoplastids,  chlorophyte algae, stramenopiles and the
#=GF CC   alveolate Perkinsus. Domain  architectures suggest that these
#=GF CC   proteins might possess mRNA editing  or DNA mutagenizing
#=GF CC   activity [1].
#=GF SQ   34
#=GS Q38A89_TRYB2/370-497      AC Q38A89.1
#=GS C5KHT8_PERM5/69-171       AC C5KHT8.1
#=GS D0N437_PHYIT/361-620      AC D0N437.1
#=GS K4E1J4_TRYCR/487-561      AC K4E1J4.1
#=GS K3X7R0_PYTUL/360-635      AC K3X7R0.1
#=GS X6NWX0_RETFI/12-193       AC X6NWX0.1
#=GS C1EFE8_MICSR/391-596      AC C1EFE8.1
#=GS D7G3E7_ECTSI/557-885      AC D7G3E7.1
#=GS C5KBD0_PERM5/165-215      AC C5KBD0.1
#=GS C1N795_MICPC/486-700      AC C1N795.1
#=GS A4HQB2_LEIBR/418-544      AC A4HQB2.1
#=GS X6MRZ3_RETFI/270-501      AC X6MRZ3.1
#=GS A0A023AZW5_GRENI/30-125   AC A0A023AZW5.1
#=GS A4HQB2_LEIBR/540-610      AC A4HQB2.1
#=GS K0SZS5_THAOC/573-878      AC K0SZS5.1
#=GS A0A067CZ46_SAPPC/307-527  AC A0A067CZ46.1
#=GS Q4Q0G6_LEIMA/412-538      AC Q4Q0G6.1
#=GS X6LM34_RETFI/14-135       AC X6LM34.1
#=GS M4BQJ0_HYAAE/354-656      AC M4BQJ0.1
#=GS A4IE07_LEIIN/127-253      AC A4IE07.1
#=GS A4IE07_LEIIN/250-318      AC A4IE07.1
#=GS B7GB54_PHATC/685-977      AC B7GB54.1
#=GS Q38A89_TRYB2/494-566      AC Q38A89.1
#=GS Q4CXE8_TRYCC/369-492      AC Q4CXE8.1
#=GS Q4DNI7_TRYCC/487-561      AC Q4DNI7.1
#=GS C5KBD0_PERM5/70-172       AC C5KBD0.1
#=GS G5AGH2_PHYSP/357-655      AC G5AGH2.1
#=GS Q4CXE8_TRYCC/487-561      AC Q4CXE8.1
#=GS C5KHT8_PERM5/164-214      AC C5KHT8.1
#=GS Q4DNI7_TRYCC/369-492      AC Q4DNI7.1
#=GS K4E1J4_TRYCR/369-492      AC K4E1J4.1
#=GS H3GUA2_PHYRM/361-650      AC H3GUA2.1
#=GS X6N209_RETFI/83-179       AC X6N209.1
#=GS Q4Q0G6_LEIMA/534-603      AC Q4Q0G6.1
Q38A89_TRYB2/370-497                 ............rt--LDLKREGAKSFFTNITLEILQFrsTMADCSWRKKDpMRQVVTSLMtyVDHKk..cHCNVTCGSRRHwsmhkpalssngngmsnatfpdhswctcprsTVMAVNYELSTPSGSRCSEQNALGK-LAS-----------------.......................------...---.--.---.----...-...........---.....................................---...........................................................................----......................................................----.........................................-------.........------..........................--.----------------.....-------------.-----------mgl..........
C5KHT8_PERM5/69-171                  .........ptavl------ANKLRDYMERTTADG---..FQPDPFFHRKS.GKLVLSMLH..VRME....------DGRDE...............................FFEGINGEVSLPTGSLCSERAAIAHARSVHPRINRGMFMGIAVIDV.......................------...---.--.---.----...-...........---.....................................---...........................................................................----......................................................----.........................................-------.........------..........................--.----------------.....-------------.-----------ptkmndgh.....
D0N437_PHYIT/361-620                 .............a-LTQMIVREMRKFRDQFLAAEGE-..GEVAGFWLRKS.RKPVLAVLL..IEKP....AAELGGRPTIV...............................VQRGMNCEVSMPTGSLCAERNAIGSALASDPTLTRRALKMIAVLGL.......................NLTAGG..nSSS.VT.SPT.ASED..tG...........DDA....................................kR-Kepsqgasfdktast...............................................stapaelhvveaanP--Qvlsvrvrpaavqsslssaa................tnnstvaaragrgrgrgrgKREL.........................................ETKNANL.........TSPRKP.........................kRPrTFSFDEVAEWLVKIAE.....ANPSFRVVTFENS.RCRNVYINQIM.............
K4E1J4_TRYCR/487-561                 .........lasmg------------------------..-----------.---------..----....-----------...............................----------------------------------------------.......................------...---.--.---.----...-...........---.....................................--L...........................................................................PTSA......................................................IREI.........................................FVHGEML.........GSKKDP..........................NP.LFPCGVCENMLRKVTRdvhdaYGGDVVLYMFDSTvNPKKLVYLPIN.............
K3X7R0_PYTUL/360-635                 .............a-MTQTLVKEMRIFRDQFLQAEGE-..GEVGNFWLRKS.RKPVLAVLL..IEKE....--DAQGVKRLI...............................VHRGMNCEVSMPTGSLCAERNAIGSALASDPTLKRRALKMIGVLSL.......................NLEGGG...GSS.VQkREE.TTTS..vS...........TTFadiphvg.......................kfqisklK--...........................................................................---Eeatttetttlrgdneeasdlgvta.....varsqavsatsinvtgasslfirspKRRL.........................................EVENSNY.........QSPRKPkrprtfscddtsveallsasesktdrNP.LAPCGACKEWLVKIAE.....ANPAFRVVTFDNS.RCRSVYVNQIM.............
X6NWX0_RETFI/12-193                  tqvgnrnvlaaeaf------------------------..-----------.-QPILAIVV..IQKP....------NEPIE...............................YFRGVNMEVAMSTGSLCAERNAIGSAFVSDPSIRREYFKMVAVLQM......................pNLPSTT..rMSK.LD.RDP.PPLRlekA...........QHH.....................................--Y...........................................................................SAST......................................................HRNQ.........................................AMLSQSNp.......fG--KNKlspsthlk.........vdedgledqNP.RGPCGACAEWLKKIAE.....VNPNFKIVTFSDV.KLAK-------flff.........
C1EFE8_MICSR/391-596                 .............r-LVTGMVQEMKKHRDVFLSMSHSK..HELGEFWLRKT.QKPVLAVLC..VRRRrdgpDDAAHGDAKPQ...............................YFRGVNLEVSMPTGSLCSERNAIGNALASDPALRRKDLFGIAVLSLgkg.................digATSGGGv.gGGA.MS.RES.SFVN..lAql.......aaGN-.....................................GGD...........................................................................DLSL......................................................CRPV.........................................TGGG---.........GGRGDL..........................NP.LKPCGACKEWLLKIAE.....VNPGFKVLMFGDV.SCDDVYIKNV-s............
D7G3E7_ECTSI/557-885                 ..............AYTRQAFDAPAG-DANGEAVVGGDtrDDLASFWLRKT.KKPVLAVLL..VQKK....------GGRPQ...............................LFRGTNMEVSMPTGSLCAERNVIGSALTSDLSLLRRDIKAVAVLSVahl................ggppASTATT...AAA.VP.IDE.RKEG...Asltg...itavDSG.....................................GGRsgwpgaagmgsavgssl........................................ttscapsplsltpamkvsPKSAllrtetgagaedke..........................rlegvrqvrrktkvV--RsiastpkrgvgsggiaaggwekspltdsgggggggrgdgggGMYSDDQgggggsnhhRHPRTSrssivah...........vppetlcsNP.LKPCGACMEWLKKIAE.....VNPDFKVITFTDS.RCGGVYIEDV-a............
C5KBD0_PERM5/165-215                 ...........ptk------------------------..-----------.---------..----....-----------...............................----------------------------------------------.......................------...---.--.---.----...-...........---.....................................---...........................................................................----......................................................----.........................................------M.........NDGHTD..........................NP.LWPCGACSEWLKKIQQ.....SVPNFRVLAFDSV.EMNVIYE----rfl..........
C1N795_MICPC/486-700                 .............a-IISRMVDEMKKHRDAYVAAASEK.tNELGAFWLRKT.RKPVLAVLC..VRKK...gKTG----RGHE...............................FYRGVNLEVSMPTGSLCSERNVIGTALACDPTLRRADLFGVAVLSL.......................KKTGGE..gSGS.GN.AQKgGVIN...Gg.........vRDG.....................................GTA...........................................................................PPTP......................................................VPGS.........................................SFAGGAS.........RNASYAndlsglgsgp......tcrpvaeddlNP.LHPCGACKEWLYKIAE.....VNPGFKVVMFTDA.SCEEVFVKTV-g............
A4HQB2_LEIBR/418-544                 .............n-IIDLKKEHPNSFFSNATRMIQHFcrTRAHCSWRKHDpTRPVVTSVLtfVDVNr..cHCHRNGDNPYNtheehieasfpsdie.amgtpsgawcqcmrrGVIAVNYELSTPSGSRCSEQNAMGK-LAS-----------------.......................------...---.--.---.----...-...........---.....................................---...........................................................................----......................................................----.........................................-------.........------..........................--.----------------.....-------------.-----------lgv..........
X6MRZ3_RETFI/270-501                 ............kd--VQKIVHEMESWKDDFSIKMKAP.kSEIETFWLRKS.YQPILAVVM..IQKP....------NEPIQ...............................YFRGVNMEVAMSTGSLCAERNAIGSAFVSDPSIRREYFKMVAVLQM......................pDLSSAA..kISK.FD.REQ.SPQP...Syycy...hfffF-CfflflllfmhafppplrlekaqhhysafmhrnqtifnQSN...........................................................................PFGN......................................................-RQS.........................................VDTKMNE.........KAPEDN..........................NP.RGPCGACSEWLKKIAE.....VNPNFKIVTFSDV.E----------litflfflp....
A0A023AZW5_GRENI/30-125              .....edtkflvgh-------------MRQFAQDYQA-..AKPDTYWHRKS.GQVVLAVLL..LRIH....-------GKLQ...............................TVRGINSELSLPSGSVCAERAAIAAALAQHLSIARSDFVSIAVLA-.......................------...---.--.---.----...-...........---.....................................---...........................................................................----......................................................----.........................................-------.........------..........................--.----------------.....-------------.-----------pnna.........
A4HQB2_LEIBR/540-610                 ..........aslg------------------------..-----------.---------..----....-----------...............................----------------------------------------------.......................------...---.--.---.----...-...........---.....................................--V...........................................................................PTWG......................................................VREV.........................................FVHGM--.........ASKKEA..........................NP.LFPCGVCENMLQRVTKdvlahYGGDITLYMFDAT.TPRKIVFLPI-p............
K0SZS5_THAOC/573-878                 ...........evs----RVTVEMKAFRVEFLQSVKEGgrSDLREFWLRKT.RKPVLAVLL..VQKP....------NHEPV...............................LYRGTNMEVSMPTGSLCAERNVIGTALASDPGLKREDLKMVAVLSVrmpkdrtyrnilpppggmsfcqpTATATS...SSD.LA.KEV.EARP...K...........QDV.....................................GMKktlsmssftsiaeglpsp......................................encvneswemdllsgfdktPTAEeaayvetpkegmlipeln.................lrnrpsdasdgsvsgsstpKRRI.........................................ALYKKKN.........RNKAGGkrqtlvvqql.....eadligflqdmNP.LKPCGACNEWLKKIAE.....SNPHFKVLTFTDE.NQAGVYVMPCQ.............
A0A067CZ46_SAPPC/307-527             .............p-LVQRLVDEMKSFRDCFVDGQHL-..GEVGSFWLRKS.RKPVLAILL..IQKT....--LPTGETALV...............................VHRGMNCEVSMPTGSLCAERNAIGSALANDPTLHRNALKMIGVLSVn.....................lAPPSTS...TSS.LP.LPR.TVSL..pTpitp..tvraaT-Dcsspkakkp...................krprtfscdGTT...........................................................................PAVAs....................................................aLAEI.........................................SAPKKEV.........PAPEDR..........................NP.LGPCGACNEWLLKIAE.....ANPSFKIITFGSM.ECDSIYVHQ--ll...........
Q4Q0G6_LEIMA/412-538                 .............t-IIDLKKEQPNTFFSNATRIIQNFcrTHAHCSWRKHNpSRLVVTSVLtfVDVNk..cHCHLNGDNPEDthderidapitadie.amgtpsgswcqcmrgGVIAVNYELSTPSGSRCSEQNAMGK-LAS-----------------.......................------...---.--.---.----...-...........---.....................................---...........................................................................----......................................................----.........................................-------.........------..........................--.----------------.....-------------.-----------lgv..........
X6LM34_RETFI/14-135                  ...........kdv---QKIVYEMERWKDDFVIKMKAP.kSEIETFWLRKS.FQPILAIVV..IQKP....------NEPIE...............................YFRGVNMEVAMSTGSLCAERNAIGSAFVSDPSIRREYFKMVAVLQM......................pNLPSTT..rM--.--.---.----...-...........---.....................................---...........................................................................----......................................................----.........................................-------.........------..........................--.----------------.....-------------.-----------skldrelspqpsg
M4BQJ0_HYAAE/354-656                 .............a-MTQRIVVEMKTFRDQFLAAEGQ-..GELASFWLRKS.RKPVLAVLL..IEKA....ASRSNESPTVV...............................VQRGMNCEVSMPTGSLCAERNAIGSALASDPTLTRRALKMIAVLGL.......................NLAGGDi.gSSDlVT.GST.PLIS...T...........DQS.....................................EERvqedgkteeellqvhtsavttfveptl....................vsgksgskttadvevavepdriqwtvsgP--Rlsedegakglilnde.......................cgqhcrasegcghgkrS--Reh.....................................vnEVTSRSL.........TKPKRPrtfscdelisd....smresrtlpdrNP.LAPCGACKEWLVKIAE.....ANPSFRVITFDNA.HCRHVYINQI-i............
A4IE07_LEIIN/127-253                 .............s-IIDLKKEQPNTFFSNATRMIQSFcrTHAHCSWRKHDpSRPVVTSVLtfVDVNk..cHCHLNGDNPENtheehidapipadie.emgtpsgswcqcmrrGVIAVNYELSTPSGSRCSEQNAMGK-LAS-----------------.......................------...---.--.---.----...-...........---.....................................---...........................................................................----......................................................----.........................................-------.........------..........................--.----------------.....-------------.-----------lgv..........
A4IE07_LEIIN/250-318                 ...........slg------------------------..-----------.---------..----....-----------...............................----------------------------------------------.......................------...---.--.---.----...-...........---.....................................--V...........................................................................PTWG......................................................VREV.........................................FVHGR--.........-AAKEP..........................NP.LFPCGVCENMLRRVTKdvlahYGGDVTLYMFDAT.TPRKIVFLTI-p............
B7GB54_PHATC/685-977                 .............p-YRHLVIDEMKAFQAEMIKTLQGQ..NDIHRFWLRKT.HKPVLAVLL..VEQE....-------GQPI...............................LYRGTNMEVSMPTGSLCAERNVIGTALAANPSLRRQDLKMIAVLAVpwq................ekltDMGSAGtlrSSE.EP.FPA.LASS..sAsltsimctttlES-.....................................--GegrktsigseheewilssapaggedgstgattnktrlppakselgnsfdlvdsgvpssssgvastapdrqpnddiPSTP......................................................VRRI.........................................ALFSRSG.........TVARKSqqavvl.............vqstrdlNP.LPPCGACNEWLKKIAE.....CNPYFCVLTFTDA.ECHGVYCTPCQ.............
Q38A89_TRYB2/494-566                 ..........smgl------------------------..-----------.---------..----....-----------...............................----------------------------------------------.......................------...---.--.---.----...-...........---.....................................---...........................................................................PTCA......................................................VREV.........................................FVHGEHQ.........GSKKDP..........................NP.LFPCGVCENMLRKVAHdvleiHGGDVMLYMYDSThNPKRLVYLPI-t............
Q4CXE8_TRYCC/369-492                 .............n-IVDLRKEPEGSFLSKLCPIIMSFrqKNAHVSWRKKDpNRPVVTSLItyIDPEe..cDCQVDCSGRGRppalmkpngrere....ekhprstwctctrsFVLAVNYELSTPSGSRCSEQNALGK-LAS-----------------.......................------...---.--.---.----...-...........---.....................................---...........................................................................----......................................................----.........................................-------.........------..........................--.----------------.....-------------.-----------mgl..........
Q4DNI7_TRYCC/487-561                 .........lasmg------------------------..-----------.---------..----....-----------...............................----------------------------------------------.......................------...---.--.---.----...-...........---.....................................--L...........................................................................PTSA......................................................IREI.........................................FVHGEML.........GSKKDP..........................NP.LFPCGVCENMLRKVTRdvhdaYGGDVVLYMFDSTvNPKKLVYLPIN.............
C5KBD0_PERM5/70-172                  .........ptavl------ANKLREYMERTTADG---..FQPEPFFHRKS.GKLVLSMLH..VRME....------DGSDE...............................FFEGINGEVSLPTGSLCSERAAIAHARSVHPRINRGMFMGIAVIDV.......................------...---.--.---.----...-...........---.....................................---...........................................................................----......................................................----.........................................-------.........------..........................--.----------------.....-------------.-----------ptkmndgh.....
G5AGH2_PHYSP/357-655                 .............a-MTQMIVREMRIFRDQFLAAEGD-..GEVASFWLRKS.RKPVLAVLL..IEKP....AAVVGDRPTIV...............................VQRGMNCEVSMPTGSLCAERNAIGSALASDPTLSRRALKMIAVLGL.......................NLTAEG..pSSN.VT.SPT.ASET..rGseregpatctkD--.....................................--Tkgngngkrdp......................................................sdaeatfdkptS--TstepgpelvaqpqpltvrirpageqsspernslslaaasprarshvggagrgrgKRGP.........................................ETKNANL.........TSPRKPkrprtfsmddva.vdemlrasgppdrNP.LAPCGACKEWLVKIAE.....ANPSFRVVTFENS.RCRNVYINQL-m............
Q4CXE8_TRYCC/487-561                 .........lasmg------------------------..-----------.---------..----....-----------...............................----------------------------------------------.......................------...---.--.---.----...-...........---.....................................--L...........................................................................PTSA......................................................IREI.........................................FVHGEML.........GSKKDP..........................NP.LFPCGVCENMLRKVTRdvhdtYGGDVVLYMFDSTvNPKKLVYLPIN.............
C5KHT8_PERM5/164-214                 ...........ptk------------------------..-----------.---------..----....-----------...............................----------------------------------------------.......................------...---.--.---.----...-...........---.....................................---...........................................................................----......................................................----.........................................------M.........NDGHTD..........................NP.LWPCGACSEWLKKIQE.....SVPNFRVLAFDSI.EMNVIYE----rfl..........
Q4DNI7_TRYCC/369-492                 .............n-IVDLRKEPEGSFLSKLCPIIMSFrqKNAHVSWRKKDpNRPVVTSLItyIDPEe..cDCQVDCSGRGRppalikpngrere....ekhprstwcnctrsFVLAVNYELSTPSGSRCSEQNALGK-LAS-----------------.......................------...---.--.---.----...-...........---.....................................---...........................................................................----......................................................----.........................................-------.........------..........................--.----------------.....-------------.-----------mgl..........
K4E1J4_TRYCR/369-492                 .............n-IVDLRKEPEGSFLSKLCPIIMSFrqKNAHVSWRKKDpNRPVVTSLItyIDPEe..cDCQVDCSGRGRppalikpngrege....ekhprstwctctrsFVLAVNYELSTPSGSRCSEQNALGK-LAS-----------------.......................------...---.--.---.----...-...........---.....................................---...........................................................................----......................................................----.........................................-------.........------..........................--.----------------.....-------------.-----------mgl..........
H3GUA2_PHYRM/361-650                 .............a-LTQMIVREMRMFRDQFLAAEGE-..GEVASFWLRKS.RKPVLAVLL..IEKP....AAVAGERPTIV...............................VQRGMNCEVSMPTGSLCAERNAIGSALASDPTLTRRALKMIAVLGL.......................NLSGSG...SNV.ISpTPS.ETRG...Sereg...gavgDDG.....................................NKKpseaqaaa...........................................................gptfdqptS--Tstagptapalpvrirpacvqsspep....pdankpaerqgsvggvgrgrgrgrgKRAL.........................................ENKNANL.........TSPRKPkrprtfsfdeva.veemmrasappdrNP.LAPCGACKEWLVKIAE.....ANPSFRVVTFENS.RCRNVYINQL-m............
X6N209_RETFI/83-179                  .............q-ITYLLIKEMEKYLKEFHAKERE-..DKMDPFWNRKS.FKSVLAVLM..VRKR....QDNDNNNNNNNnnnnn....................nskqyvFYRGRNTEISLPVGSHCAERAAIVT---------------------.......................------...---.--.---.----...-...........---.....................................---...........................................................................----......................................................----.........................................-------.........------..........................--.----------------.....-------------.-----------lcq..........
Q4Q0G6_LEIMA/534-603                 ..........aslg------------------------..-----------.---------..----....-----------...............................----------------------------------------------.......................------...---.--.---.----...-...........---.....................................--V...........................................................................PTWG......................................................VREV.........................................FVHGM--.........-AATEP..........................NP.LFPCGVCENMLRRVTKdvlahYGGDVTLYMFDAT.TPRKIVFLPI-p............
#=GC seq_cons                        .............s.....hh...t.ahpphh....t...tphts.Wh+Ks..+sVls.lh..lph...........tt..................................hhhuhNhElShPoGShCuEpNAlGp.hss...............................................................................................................................................................................................................................................................................................................................tt...........................NP.hhPCGsCtphLh+ltc......ssthhlhhFts..p.t.....................
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