GenomeNet

Database: Pfam
Entry: LmjF365940-deam
LinkDB: LmjF365940-deam
Original site: LmjF365940-deam 
#=GF ID   LmjF365940-deam
#=GF AC   PF14421.4
#=GF DE   A distinct subfamily of CDD/CDA-like deaminases
#=GF PI   CDD_CDA_1;
#=GF AU   Iyer LM, Zhang D, Aravind L
#=GF SE   Manual
#=GF GA   45.70 45.70;
#=GF TC   69.30 47.30;
#=GF NC   32.60 45.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   21890906
#=GF RT   Evolution of the deaminase fold and multiple origins of
#=GF RT   eukaryotic editing and mutagenic nucleic acid deaminases from
#=GF RT   bacterial toxin systems.
#=GF RA   Iyer LM, Zhang D, Rogozin IB, Aravind L;
#=GF RL   Nucleic Acids Res. 2011; [Epub ahead of print]
#=GF DR   INTERPRO; IPR032723;
#=GF CC   A distinct branch of the CDD/CDA-like deaminases prototyped by 
#=GF CC   Leishmania LmjF36.5940. Members of this family are widely
#=GF CC   distributed across several microbial eukaryotes such as
#=GF CC   kinetoplastids,  chlorophyte algae, stramenopiles and the
#=GF CC   alveolate Perkinsus. Domain  architectures suggest that these
#=GF CC   proteins might possess mRNA editing  or DNA mutagenizing
#=GF CC   activity [1].
#=GF SQ   61
#=GS Q38A89_TRYB2/370-497      AC Q38A89.1
#=GS A0A0M9G3M3_9TRYP/540-608  AC A0A0M9G3M3.1
#=GS C5KHT8_PERM5/69-171       AC C5KHT8.1
#=GS D0N437_PHYIT/361-620      AC D0N437.1
#=GS K4E1J4_TRYCR/487-561      AC K4E1J4.1
#=GS K3X7R0_PYTUL/360-635      AC K3X7R0.1
#=GS X6NWX0_RETFI/12-193       AC X6NWX0.1
#=GS C1EFE8_MICSR/391-596      AC C1EFE8.1
#=GS D7G3E7_ECTSI/557-885      AC D7G3E7.1
#=GS T0RET2_9STRA/307-526      AC T0RET2.1
#=GS C5KBD0_PERM5/165-215      AC C5KBD0.1
#=GS V5B3J9_TRYCR/369-492      AC V5B3J9.1
#=GS W4FWW5_9STRA/333-560      AC W4FWW5.1
#=GS A0A061J7V9_TRYRA/488-561  AC A0A061J7V9.1
#=GS C1N795_MICPC/486-700      AC C1N795.1
#=GS A4HQB2_LEIBR/418-544      AC A4HQB2.1
#=GS S9TLD4_9TRYP/398-468      AC S9TLD4.1
#=GS A0A0G4GFE1_9ALVE/70-165   AC A0A0G4GFE1.1
#=GS X6MRZ3_RETFI/270-501      AC X6MRZ3.1
#=GS W7U454_9STRA/578-921      AC W7U454.1
#=GS A0A024TN09_9STRA/318-550  AC A0A024TN09.1
#=GS A0A023AZW5_GRENI/30-125   AC A0A023AZW5.1
#=GS A0A0G4GFE1_9ALVE/164-210  AC A0A0G4GFE1.1
#=GS K2NCU0_TRYCR/368-491      AC K2NCU0.1
#=GS A4HQB2_LEIBR/540-610      AC A4HQB2.1
#=GS K0SZS5_THAOC/573-878      AC K0SZS5.1
#=GS A0A067CZ46_SAPPC/307-527  AC A0A067CZ46.1
#=GS W6KP16_9TRYP/490-557      AC W6KP16.1
#=GS A0A0N0P9C3_LEPSE/542-611  AC A0A0N0P9C3.1
#=GS Q4Q0G6_LEIMA/412-538      AC Q4Q0G6.1
#=GS X6LM34_RETFI/14-135       AC X6LM34.1
#=GS V5B3J9_TRYCR/487-561      AC V5B3J9.1
#=GS A4IE07_LEIIN/127-253      AC A4IE07.1
#=GS M4BQJ0_HYAAE/354-656      AC M4BQJ0.1
#=GS S9TLD4_9TRYP/274-402      AC S9TLD4.1
#=GS A0A0G4EQ48_9ALVE/40-135   AC A0A0G4EQ48.1
#=GS W6KP16_9TRYP/361-493      AC W6KP16.1
#=GS A4IE07_LEIIN/250-318      AC A4IE07.1
#=GS Q4CXE8_TRYCC/369-492      AC Q4CXE8.1
#=GS B7GB54_PHATC/685-977      AC B7GB54.1
#=GS A0A0N0P9C3_LEPSE/419-545  AC A0A0N0P9C3.1
#=GS Q38A89_TRYB2/494-566      AC Q38A89.1
#=GS C5KBD0_PERM5/70-172       AC C5KBD0.1
#=GS Q4DNI7_TRYCC/487-561      AC Q4DNI7.1
#=GS Q4CXE8_TRYCC/487-561      AC Q4CXE8.1
#=GS G5AGH2_PHYSP/357-655      AC G5AGH2.1
#=GS V9EIB2_PHYPR/372-640      AC V9EIB2.1
#=GS C5KHT8_PERM5/164-214      AC C5KHT8.1
#=GS A0A0M9G3M3_9TRYP/416-542  AC A0A0M9G3M3.1
#=GS A0A0M0JEH7_9EUKA/250-416  AC A0A0M0JEH7.1
#=GS A0A0G4ECT7_9ALVE/249-344  AC A0A0G4ECT7.1
#=GS A0A0G4IVG2_PLABS/332-537  AC A0A0G4IVG2.1
#=GS Q4DNI7_TRYCC/369-492      AC Q4DNI7.1
#=GS K2NCU0_TRYCR/486-560      AC K2NCU0.1
#=GS W4FZ70_9STRA/317-544      AC W4FZ70.1
#=GS K4E1J4_TRYCR/369-492      AC K4E1J4.1
#=GS A0A061J7V9_TRYRA/369-492  AC A0A061J7V9.1
#=GS H3GUA2_PHYRM/361-650      AC H3GUA2.1
#=GS X6N209_RETFI/83-179       AC X6N209.1
#=GS Q4Q0G6_LEIMA/534-603      AC Q4Q0G6.1
#=GS W2PRR7_PHYPN/372-640      AC W2PRR7.1
Q38A89_TRYB2/370-497                 ............rt--LDLKREGAKSFFTNITLEILQFr..sTMADCSWRKKDpMRQVVTSLMtyVDHKk..cHCNVTCGSRRHwsmhkpalssngngm.......snatfpdhswctcprsTVMAVNYELSTPSGSRCSEQNALGK-LAS-----------------..............................------...---.--.---.----...-...........---.....................................---...........................................................................................................................----......................................................----.........................................-------.........------....................................--.----------------.....-------------.-----------mgl..........
A0A0M9G3M3_9TRYP/540-608             ...........lgv------------------------....-----------.---------..----....-----------......................................----------------------------------------------..............................------...---.--.---.----...-...........---.....................................---...........................................................................................................................PTWG......................................................VREV.........................................FVHGM--.........NIKKEA....................................NP.LFPCGVCENMLQKVTKdvmshYGGDVTLYMFDAT.HPRKIVFLTI-p............
C5KHT8_PERM5/69-171                  .........ptavl------ANKLRDYMERTTADG---....FQPDPFFHRKS.GKLVLSMLH..VRME....------DGRDE......................................FFEGINGEVSLPTGSLCSERAAIAHARSVHPRINRGMFMGIAVIDV..............................------...---.--.---.----...-...........---.....................................---...........................................................................................................................----......................................................----.........................................-------.........------....................................--.----------------.....-------------.-----------ptkmndgh.....
D0N437_PHYIT/361-620                 .............a-LTQMIVREMRKFRDQFLAAEGE-....GEVAGFWLRKS.RKPVLAVLL..IEKP....AAELGGRPTIV......................................VQRGMNCEVSMPTGSLCAERNAIGSALASDPTLTRRALKMIAVLGL..............................NLTAGG..nSSS.VT.SPT.ASED..tG...........DDA....................................kR-Kepsqgasfdktast...............................................................................................stapaelhvveaanP--Qvlsvrvrpaavqsslssaa................tnnstvaaragrgrgrgrgKREL.........................................ETKNANL.........TSPRKP...................................kRPrTFSFDEVAEWLVKIAE.....ANPSFRVVTFENS.RCRNVYINQIM.............
K4E1J4_TRYCR/487-561                 .........lasmg------------------------....-----------.---------..----....-----------......................................----------------------------------------------..............................------...---.--.---.----...-...........---.....................................--L...........................................................................................................................PTSA......................................................IREI.........................................FVHGEML.........GSKKDP....................................NP.LFPCGVCENMLRKVTRdvhdaYGGDVVLYMFDSTvNPKKLVYLPIN.............
K3X7R0_PYTUL/360-635                 .............a-MTQTLVKEMRIFRDQFLQAEGE-....GEVGNFWLRKS.RKPVLAVLL..IEKE....--DAQGVKRLI......................................VHRGMNCEVSMPTGSLCAERNAIGSALASDPTLKRRALKMIGVLSL..............................NLEGGG...GSS.VQkREE.TTTS..vS...........TTFadiphvg.......................kfqisklK--...........................................................................................................................---Eeatttetttlrgdneeasdlgvta.....varsqavsatsinvtgasslfirspKRRL.........................................EVENSNY.........QSPRKPkrprtfscddtsv..........eallsasesktdrNP.LAPCGACKEWLVKIAE.....ANPAFRVVTFDNS.RCRSVYVNQIM.............
X6NWX0_RETFI/12-193                  tqvgnrnvlaaeaf------------------------....-----------.-QPILAIVV..IQKP....------NEPIE......................................YFRGVNMEVAMSTGSLCAERNAIGSAFVSDPSIRREYFKMVAVLQM.............................pNLPSTT..rMSK.LD.RDP.PPLRlekA...........QHH.....................................--Y...........................................................................................................................SAST......................................................HRNQ.........................................AMLSQSNp.......fG--KNKlspsthlk...................vdedgledqNP.RGPCGACAEWLKKIAE.....VNPNFKIVTFSDV.KLAK-------flff.........
C1EFE8_MICSR/391-596                 .............r-LVTGMVQEMKKHRDVFLSMSHSK....HELGEFWLRKT.QKPVLAVLC..VRRRrdgpDDAAHGDAKPQ......................................YFRGVNLEVSMPTGSLCSERNAIGNALASDPALRRKDLFGIAVLSLgkg........................digATSGGGv.gGGA.MS.RES.SFVN..lAql.......aaGN-.....................................GGD...........................................................................................................................DLSL......................................................CRPV.........................................TGGG---.........GGRGDL....................................NP.LKPCGACKEWLLKIAE.....VNPGFKVLMFGDV.SCDDVYIKNV-s............
D7G3E7_ECTSI/557-885                 ..............AYTRQAFDAPAG-DANGEAVVGGDt..rDDLASFWLRKT.KKPVLAVLL..VQKK....------GGRPQ......................................LFRGTNMEVSMPTGSLCAERNVIGSALTSDLSLLRRDIKAVAVLSVahl.......................ggppASTATT...AAA.VP.IDE.RKEG...Asltg...itavDSG.....................................GGRsgwpgaagmgsavgssl........................................................................................ttscapsplsltpamkvsPKSAllrtetgagaedke..........................rlegvrqvrrktkvV--RsiastpkrgvgsggiaaggwekspltdsgggggggrgdgggGMYSDDQgggggsnhhRHPRTSrssivah.....................vppetlcsNP.LKPCGACMEWLKKIAE.....VNPDFKVITFTDS.RCGGVYIEDV-a............
T0RET2_9STRA/307-526                 ..........plvl----RLVDEMKAFRDCFVDGQHL-....GEVGSFWLRKS.RKPVLAILL..IQKT....--LPNGETALV......................................VHRGMNCEVSMPTGSLCAERNAIGSALANDPTLHRNALKMIGVLSV..............................NLAPSS..sTTA.LP.LPR.TVSL..pTpimp...tvraA-Adcsspkakk..................pkrprtfscdGTT...........................................................................................................................PAVAs....................................................aLAEI.........................................SAPKKEV.........PAPEDR....................................NP.LGPCGACNEWLLKIAE.....ANPSFKIITFGSM.ECDSIYVHQ--ll...........
C5KBD0_PERM5/165-215                 ...........ptk------------------------....-----------.---------..----....-----------......................................----------------------------------------------..............................------...---.--.---.----...-...........---.....................................---...........................................................................................................................----......................................................----.........................................------M.........NDGHTD....................................NP.LWPCGACSEWLKKIQQ.....SVPNFRVLAFDSV.EMNVIYE----rfl..........
V5B3J9_TRYCR/369-492                 .............n-IVDLRKEPEGSFLSKLCPIIMSFr..qKNAHVSWRKKDpNRPVVTSLItyIDPEe..cDCQVDCSGRGRppalikpngrege...........ekhprstwctctrsFVLAVNYELSTPSGSRCSEQNALGK-LAS-----------------..............................------...---.--.---.----...-...........---.....................................---...........................................................................................................................----......................................................----.........................................-------.........------....................................--.----------------.....-------------.-----------mgl..........
W4FWW5_9STRA/333-560                 .............p-LVARAVDEIKAFRDQFVQGEHL-....GEVGQFWLRKS.RKPVLAVLL..VEKR....--TSSGDVQVV......................................VHRGMNCEVSMPTGSLCAERNAIGSALANDPTLLRQSLKMIAVLSVslhplklapppppslsstslllpappalilA----H...ATT.TT.VTT.----...-...........--Avea..............................spktGRK...........................................................................................................................PKRP......................................................-RTIscdas..............................vpsiqaALDAVDAs.......aATEKDL....................................NP.LAPCGACNEWLLKIAE.....ANPSFKIVTFDSI.DCDSVYIHQ--ll...........
A0A061J7V9_TRYRA/488-561             ..........asmg------------------------....-----------.---------..----....-----------......................................----------------------------------------------..............................------...---.--.---.----...-...........---.....................................--L...........................................................................................................................PTSA......................................................IREV.........................................FVHGENR.........RAQTDP....................................NP.LFPCGVCENMLRRVTRdvyetYGGDVVLYMFDSTvNPKKLVYLPV-n............
C1N795_MICPC/486-700                 .............a-IISRMVDEMKKHRDAYVAAASEK...tNELGAFWLRKT.RKPVLAVLC..VRKK...gKTG----RGHE......................................FYRGVNLEVSMPTGSLCSERNVIGTALACDPTLRRADLFGVAVLSL..............................KKTGGE..gSGS.GN.AQKgGVIN...Gg.........vRDG.....................................GTA...........................................................................................................................PPTP......................................................VPGS.........................................SFAGGAS.........RNASYAndlsglgsgp................tcrpvaeddlNP.LHPCGACKEWLYKIAE.....VNPGFKVVMFTDA.SCEEVFVKTV-g............
A4HQB2_LEIBR/418-544                 .............n-IIDLKKEHPNSFFSNATRMIQHFc..rTRAHCSWRKHDpTRPVVTSVLtfVDVNr..cHCHRNGDNPYNtheehieasfpsdie........amgtpsgawcqcmrrGVIAVNYELSTPSGSRCSEQNAMGK-LAS-----------------..............................------...---.--.---.----...-...........---.....................................---...........................................................................................................................----......................................................----.........................................-------.........------....................................--.----------------.....-------------.-----------lgv..........
S9TLD4_9TRYP/398-468                 ..........aslg------------------------....-----------.---------..----....-----------......................................----------------------------------------------..............................------...---.--.---.----...-...........---.....................................--V...........................................................................................................................PTWS......................................................VREV.........................................FVYGL--.........NPKKES....................................NP.LFPCGVCENMLQKVNSdiskhYGNEATLFMFDAT.KPHKVVYLPV-a............
A0A0G4GFE1_9ALVE/70-165              ............pl---KRLVDEMRRFVNDWKSFEAA-....GEMDPFWHRKS.SKTVLAVVM..VVNK....------SGQEM......................................FYRGMNSEISLPSGSNCAERSAISTCISNSLDVRRSDFRAIAV---..............................------...---.--.---.----...-...........---.....................................---...........................................................................................................................----......................................................----.........................................-------.........------....................................--.----------------.....-------------.-----------ad...........
X6MRZ3_RETFI/270-501                 ............kd--VQKIVHEMESWKDDFSIKMKAP...kSEIETFWLRKS.YQPILAVVM..IQKP....------NEPIQ......................................YFRGVNMEVAMSTGSLCAERNAIGSAFVSDPSIRREYFKMVAVLQM.............................pDLSSAA..kISK.FD.REQ.SPQP...Syycy...hfffF-CfflflllfmhafppplrlekaqhhysafmhrnqtifnQSN...........................................................................................................................PFGN......................................................-RQS.........................................VDTKMNE.........KAPEDN....................................NP.RGPCGACSEWLKKIAE.....VNPNFKIVTFSDV.E----------litflfflp....
W7U454_9STRA/578-921                 ...........ara---RLVAQEMLRYKEEVLLHYRQGl..cADLSTFWLRKT.EKPVLAVLL..VQKD....------RARPL......................................LYRGCNMEVSMPTGSLCAERNAIGSALAADLTLKRRDLKVVAVLSVsfg........................kngNTGGGGg.gGDG.GR.KPE.GTAK...Aldav...fasiDT-.....................................--AprvasqttdrnhsysdsctghsignaqprgllgprkgdagasertggsmmasvgdqegpwtpssrrtgaqeevfdglspprttiirsysvkdlngcgqdgafgkpspaecrgrphassmdsldPKS-......................................................----.........................................-------.........-----SkstspiiplsnlrvdgggrdqqgpgamtirveaddlNP.LKPCGACMEWLKKIAE.....KNPEFRVATFTDE.ACRGIYTEF--vs...........
A0A024TN09_9STRA/318-550             .............p-IVTRLVNEVKSFRDQFVQGEHL-....GEVGQFWLRKS.RKPVLAVLL..IEKL....---VDGTPTIV......................................VHRGMNCEVSMPTGSLCAERNAIGSALANDPTLLRQSLKMIAVLSVtlhs.....................hpkqvA---MA...SAA.QPpCSS.T---...-...........--Alpidapppvlvnvp.........ssiqpsnverspkaGRK...........................................................................................................................PKRPrtiscda.......................................svpaiqaaLTAV.........................................DAATAMA.........KAEKDL....................................NP.LAPCGACNEWLLKIAE.....ANPSFKIVTFDSI.DCDSVYIHQ--ll...........
A0A023AZW5_GRENI/30-125              .....edtkflvgh-------------MRQFAQDYQA-....AKPDTYWHRKS.GQVVLAVLL..LRIH....-------GKLQ......................................TVRGINSELSLPSGSVCAERAAIAAALAQHLSIARSDFVSIAVLA-..............................------...---.--.---.----...-...........---.....................................---...........................................................................................................................----......................................................----.........................................-------.........------....................................--.----------------.....-------------.-----------pnna.........
A0A0G4GFE1_9ALVE/164-210             ...........adp------------------------....-----------.---------..----....-----------......................................----------------------------------------------..............................------...---.--.---.----...-...........---.....................................---...........................................................................................................................----......................................................----.........................................-------.........---KDE...................................lNP.IAPCGVCDEWLQKIQE.....ESPGFSIVTFTTS.ECNEI------rerc.........
K2NCU0_TRYCR/368-491                 .............n-IVDLRKEPEGSFLSKVCPIIMSFr..qKNAHVSWRKKDpNRPVVTSLItyIDPDe..cNCQVDCSGRGRpptlmepnsrege...........ekhprstwctctrsFVLAVNYELSTPSGSRCSEQNALGK-LAS-----------------..............................------...---.--.---.----...-...........---.....................................---...........................................................................................................................----......................................................----.........................................-------.........------....................................--.----------------.....-------------.-----------mgl..........
A4HQB2_LEIBR/540-610                 ..........aslg------------------------....-----------.---------..----....-----------......................................----------------------------------------------..............................------...---.--.---.----...-...........---.....................................--V...........................................................................................................................PTWG......................................................VREV.........................................FVHGM--.........ASKKEA....................................NP.LFPCGVCENMLQRVTKdvlahYGGDITLYMFDAT.TPRKIVFLPI-p............
K0SZS5_THAOC/573-878                 ...........evs----RVTVEMKAFRVEFLQSVKEGg..rSDLREFWLRKT.RKPVLAVLL..VQKP....------NHEPV......................................LYRGTNMEVSMPTGSLCAERNVIGTALASDPGLKREDLKMVAVLSVrmpkdrtyrni.......lpppggmsfcqpTATATS...SSD.LA.KEV.EARP...K...........QDV.....................................GMKktlsmssftsiaeglpsp......................................................................................encvneswemdllsgfdktPTAEeaayvetpkegmlipeln.................lrnrpsdasdgsvsgsstpKRRI.........................................ALYKKKN.........RNKAGGkrqtlvvqql...............eadligflqdmNP.LKPCGACNEWLKKIAE.....SNPHFKVLTFTDE.NQAGVYVMPCQ.............
A0A067CZ46_SAPPC/307-527             .............p-LVQRLVDEMKSFRDCFVDGQHL-....GEVGSFWLRKS.RKPVLAILL..IQKT....--LPTGETALV......................................VHRGMNCEVSMPTGSLCAERNAIGSALANDPTLHRNALKMIGVLSVn............................lAPPSTS...TSS.LP.LPR.TVSL..pTpitp..tvraaT-Dcsspkakkp...................krprtfscdGTT...........................................................................................................................PAVAs....................................................aLAEI.........................................SAPKKEV.........PAPEDR....................................NP.LGPCGACNEWLLKIAE.....ANPSFKIITFGSM.ECDSIYVHQ--ll...........
W6KP16_9TRYP/490-557                 ...........slg------------------------....-----------.---------..----....-----------......................................----------------------------------------------..............................------...---.--.---.----...-...........---.....................................--V...........................................................................................................................PTWS......................................................VREL.........................................FVHGS--.........--SEHV....................................NP.LFPCGVCDNMLQRVAKdvrtrYGGEIRLYMFDAT.VPSKVVSLP--ms...........
A0A0N0P9C3_LEPSE/542-611             ...........slg------------------------....-----------.---------..----....-----------......................................----------------------------------------------..............................------...---.--.---.----...-...........---.....................................--V...........................................................................................................................PTWG......................................................VREV.........................................FVHVM--.........NAKKEA....................................NP.LFPCGVCENMLQKVTKdvmshYGGDVTLYMFDAT.QPRKIVFLTI-p............
Q4Q0G6_LEIMA/412-538                 .............t-IIDLKKEQPNTFFSNATRIIQNFc..rTHAHCSWRKHNpSRLVVTSVLtfVDVNk..cHCHLNGDNPEDthderidapitadie........amgtpsgswcqcmrgGVIAVNYELSTPSGSRCSEQNAMGK-LAS-----------------..............................------...---.--.---.----...-...........---.....................................---...........................................................................................................................----......................................................----.........................................-------.........------....................................--.----------------.....-------------.-----------lgv..........
X6LM34_RETFI/14-135                  ...........kdv---QKIVYEMERWKDDFVIKMKAP...kSEIETFWLRKS.FQPILAIVV..IQKP....------NEPIE......................................YFRGVNMEVAMSTGSLCAERNAIGSAFVSDPSIRREYFKMVAVLQM.............................pNLPSTT..rM--.--.---.----...-...........---.....................................---...........................................................................................................................----......................................................----.........................................-------.........------....................................--.----------------.....-------------.-----------skldrelspqpsg
V5B3J9_TRYCR/487-561                 .........lasmg------------------------....-----------.---------..----....-----------......................................----------------------------------------------..............................------...---.--.---.----...-...........---.....................................--L...........................................................................................................................PTSA......................................................IREI.........................................FVHGEML.........GSKKDP....................................NP.LFPCGVCENMLRKVTRdvhdaYGGDVVLYMFDSTvNPKKLVYLPIN.............
A4IE07_LEIIN/127-253                 .............s-IIDLKKEQPNTFFSNATRMIQSFc..rTHAHCSWRKHDpSRPVVTSVLtfVDVNk..cHCHLNGDNPENtheehidapipadie........emgtpsgswcqcmrrGVIAVNYELSTPSGSRCSEQNAMGK-LAS-----------------..............................------...---.--.---.----...-...........---.....................................---...........................................................................................................................----......................................................----.........................................-------.........------....................................--.----------------.....-------------.-----------lgv..........
M4BQJ0_HYAAE/354-656                 .............a-MTQRIVVEMKTFRDQFLAAEGQ-....GELASFWLRKS.RKPVLAVLL..IEKA....ASRSNESPTVV......................................VQRGMNCEVSMPTGSLCAERNAIGSALASDPTLTRRALKMIAVLGL..............................NLAGGDi.gSSDlVT.GST.PLIS...T...........DQS.....................................EERvqedgkteeellqvhtsavttfveptl....................................................................vsgksgskttadvevavepdriqwtvsgP--Rlsedegakglilnde.......................cgqhcrasegcghgkrS--Reh.....................................vnEVTSRSL.........TKPKRPrtfscdelisd..............smresrtlpdrNP.LAPCGACKEWLVKIAE.....ANPSFRVITFDNA.HCRHVYINQI-i............
S9TLD4_9TRYP/274-402                 ............cv--VNLSKEPPESFFSRVTNIIKSFsvegRNAHCSWRKNDpTRPLVTSVFtyVDVN....TCRCGDVSRVLnvdddasvraeldpvt......eniglpprvwctcarhYVVAVNYELSTPSGSRCSEQNAMGK-LAS-----------------..............................------...---.--.---.----...-...........---.....................................---...........................................................................................................................----......................................................----.........................................-------.........------....................................--.----------------.....-------------.-----------lgv..........
A0A0G4EQ48_9ALVE/40-135              ..........plkr-----LVDEARRYVNEWKSLE---....SQMDSFWHRKS.SKIVLAVVM..VVEK....-------GRLR......................................FYRGMNSEISLPSGSNCAERSAISTCISNMLTVRRSDFRAIAVVD-..............................------...---.--.---.----...-...........---.....................................---...........................................................................................................................----......................................................----.........................................-------.........------....................................--.----------------.....-------------.-----------pkd..........
W6KP16_9TRYP/361-493                 .............k-VTRLSKEPADSFLVRVTDIINGFr..aLHAHCSWRKHNpHRTVVTSILtyVDVR....GCQCGLLPPGSplrggdedddnafpalpsippgaaiglperswctcarrWEVGVNYELSTPSGSRCSEQNAMGK-LAS-----------------..............................------...---.--.---.----...-...........---.....................................---...........................................................................................................................----......................................................----.........................................-------.........------....................................--.----------------.....-------------.-----------lgv..........
A4IE07_LEIIN/250-318                 ...........slg------------------------....-----------.---------..----....-----------......................................----------------------------------------------..............................------...---.--.---.----...-...........---.....................................--V...........................................................................................................................PTWG......................................................VREV.........................................FVHGR--.........-AAKEP....................................NP.LFPCGVCENMLRRVTKdvlahYGGDVTLYMFDAT.TPRKIVFLTI-p............
Q4CXE8_TRYCC/369-492                 .............n-IVDLRKEPEGSFLSKLCPIIMSFr..qKNAHVSWRKKDpNRPVVTSLItyIDPEe..cDCQVDCSGRGRppalmkpngrere...........ekhprstwctctrsFVLAVNYELSTPSGSRCSEQNALGK-LAS-----------------..............................------...---.--.---.----...-...........---.....................................---...........................................................................................................................----......................................................----.........................................-------.........------....................................--.----------------.....-------------.-----------mgl..........
B7GB54_PHATC/685-977                 .............p-YRHLVIDEMKAFQAEMIKTLQGQ....NDIHRFWLRKT.HKPVLAVLL..VEQE....-------GQPI......................................LYRGTNMEVSMPTGSLCAERNVIGTALAANPSLRRQDLKMIAVLAVpwq.......................ekltDMGSAGtlrSSE.EP.FPA.LASS..sAsltsimctttlES-.....................................--Gegrktsigseheewilssapaggedgstgattnktrl................................................ppakselgnsfdlvdsgvpssssgvastapdrqpnddiPSTP......................................................VRRI.........................................ALFSRSG.........TVARKSqqavvl.......................vqstrdlNP.LPPCGACNEWLKKIAE.....CNPYFCVLTFTDA.ECHGVYCTPCQ.............
A0A0N0P9C3_LEPSE/419-545             .............n-IVDLKKEDSRSFFSVVTRMMLNFp..tVHAHKSWRKHDsTRPVVTSVLtfVDVNt..cHCHRCGHSPENaceehidavipadia........vvgvprgswchctrrAVIAVNYELSTPSGSRCSEQNAMGK-LAS-----------------..............................------...---.--.---.----...-...........---.....................................---...........................................................................................................................----......................................................----.........................................-------.........------....................................--.----------------.....-------------.-----------lgv..........
Q38A89_TRYB2/494-566                 ..........smgl------------------------....-----------.---------..----....-----------......................................----------------------------------------------..............................------...---.--.---.----...-...........---.....................................---...........................................................................................................................PTCA......................................................VREV.........................................FVHGEHQ.........GSKKDP....................................NP.LFPCGVCENMLRKVAHdvleiHGGDVMLYMYDSThNPKRLVYLPI-t............
C5KBD0_PERM5/70-172                  .........ptavl------ANKLREYMERTTADG---....FQPEPFFHRKS.GKLVLSMLH..VRME....------DGSDE......................................FFEGINGEVSLPTGSLCSERAAIAHARSVHPRINRGMFMGIAVIDV..............................------...---.--.---.----...-...........---.....................................---...........................................................................................................................----......................................................----.........................................-------.........------....................................--.----------------.....-------------.-----------ptkmndgh.....
Q4DNI7_TRYCC/487-561                 .........lasmg------------------------....-----------.---------..----....-----------......................................----------------------------------------------..............................------...---.--.---.----...-...........---.....................................--L...........................................................................................................................PTSA......................................................IREI.........................................FVHGEML.........GSKKDP....................................NP.LFPCGVCENMLRKVTRdvhdaYGGDVVLYMFDSTvNPKKLVYLPIN.............
Q4CXE8_TRYCC/487-561                 .........lasmg------------------------....-----------.---------..----....-----------......................................----------------------------------------------..............................------...---.--.---.----...-...........---.....................................--L...........................................................................................................................PTSA......................................................IREI.........................................FVHGEML.........GSKKDP....................................NP.LFPCGVCENMLRKVTRdvhdtYGGDVVLYMFDSTvNPKKLVYLPIN.............
G5AGH2_PHYSP/357-655                 .............a-MTQMIVREMRIFRDQFLAAEGD-....GEVASFWLRKS.RKPVLAVLL..IEKP....AAVVGDRPTIV......................................VQRGMNCEVSMPTGSLCAERNAIGSALASDPTLSRRALKMIAVLGL..............................NLTAEG..pSSN.VT.SPT.ASET..rGseregpatctkD--.....................................--Tkgngngkrdp......................................................................................................sdaeatfdkptS--TstepgpelvaqpqpltvrirpageqsspernslslaaasprarshvggagrgrgKRGP.........................................ETKNANL.........TSPRKPkrprtfsmddva...........vdemlrasgppdrNP.LAPCGACKEWLVKIAE.....ANPSFRVVTFENS.RCRNVYINQL-m............
V9EIB2_PHYPR/372-640                 .............a-MTQMIVREMRKFRDQFLAAEGE-....GEVAGFWLRKS.RKPVLAVLL..IEKP....AAELGGRPTIV......................................VQRGMNCEVSMPTGSLCAERNAIGSALASDPTLTRRALKMIAVLGL..............................NLTAGG...NIS.VT.SPT.ASED..tA...........DDKke................................psdG-Atfdkkt..............................................................................................................stavepaN--Sqvllvrvrpaavqssrss..................aavnnlsvddagrgrgrgKRAL.........................................ETKNANL.........TSPRKPkrprtfsfdeva...........veemmrasappdrNP.LAPCGACKEWLVKIAE.....ANPSFRVVTFENS.RCRNVYINQL-m............
C5KHT8_PERM5/164-214                 ...........ptk------------------------....-----------.---------..----....-----------......................................----------------------------------------------..............................------...---.--.---.----...-...........---.....................................---...........................................................................................................................----......................................................----.........................................------M.........NDGHTD....................................NP.LWPCGACSEWLKKIQE.....SVPNFRVLAFDSI.EMNVIYE----rfl..........
A0A0M9G3M3_9TRYP/416-542             .............n-VIDLKREDDDSFFIVVTRMILNFr..tHHAHNSWRKHDpTRPVVTSVLtfVDVNe..cHCHRNGGDANNtieehidavipddta........vvgvpsgswcncprrAVIAVNYELSTPSGSRCSEQNAMGK-LAS-----------------..............................------...---.--.---.----...-...........---.....................................---...........................................................................................................................----......................................................----.........................................-------.........------....................................--.----------------.....-------------.-----------lgv..........
A0A0M0JEH7_9EUKA/250-416             ..........eekg-----LVDEMVQYKRQFEAVRDSN...tHELGTFWLRKT.GKAVLAVLL..TKSP....------LGELT......................................FWRGMNVEVSMPTGTLCAERNAIGNALAGDHSVHRRDMLAVAVLSV..............................TL----...---.--.---.----...-...........---.....................................-SP...........................................................................................................................PKHE......................................................VTDQ.........................................ALERT--.........TSPDDEv.................................alNP.LDPCGACMEWLRKIAE.....VNPDFKVLTFTST.SCEKVFITPI-g............
A0A0G4ECT7_9ALVE/249-344             ...........plk----RIVDEARRYVNEWKSLE---....GQMDSFWHRKS.SKIVLAVVM..VVDK....------NGQER......................................FYRGMNSEISLPSGSNCAERAAISACISNSLTVRRSDFRAIAVVD-..............................------...---.--.---.----...-...........---.....................................---...........................................................................................................................----......................................................----.........................................-------.........------....................................--.----------------.....-------------.-----------pk...........
A0A0G4IVG2_PLABS/332-537             ..........lhlg-----LVEKMKERRQAFVLALRND....HELRAFWLRKT.FKPVLSVLL..VMKP....------GGVPQ......................................YFSGMNMEVSMPTGSLCAERNAIGNALAQDPTLHREHFKAMAVLSV..............................SMGSAD...PSN.GD.STS.THHW..hT...........DVAs...................................pPNS...........................................................................................................................PTLAad.................................................awdDRRF.........................................NIRPTRSq......tmRHATTQsvsp...........................ylralNP.INPCGACKEWLKKIAL.....VNPDFVVLTFPSM.ICDSVFVRPV-l............
Q4DNI7_TRYCC/369-492                 .............n-IVDLRKEPEGSFLSKLCPIIMSFr..qKNAHVSWRKKDpNRPVVTSLItyIDPEe..cDCQVDCSGRGRppalikpngrere...........ekhprstwcnctrsFVLAVNYELSTPSGSRCSEQNALGK-LAS-----------------..............................------...---.--.---.----...-...........---.....................................---...........................................................................................................................----......................................................----.........................................-------.........------....................................--.----------------.....-------------.-----------mgl..........
K2NCU0_TRYCR/486-560                 .........lasmg------------------------....-----------.---------..----....-----------......................................----------------------------------------------..............................------...---.--.---.----...-...........---.....................................--L...........................................................................................................................PTSA......................................................IREI.........................................FVHGEML.........GSKKDP....................................NP.LFPCGVCENMLRKVTRdvhdtYGGDIVLYMFDSTvNPKKLVYLPIN.............
W4FZ70_9STRA/317-544                 .............p-LVARAVDEIKAFRDQFVQGEHL-....GEVGQFWLRKS.RKPVLAVLL..VEKR....--TSSGDVQVV......................................VHRGMNCEVSMPTGSLCAERNAIGSALANDPTLLRQSLKMIAVLSVslhplklapppppslsstslllpappalilA----H...ATT.TT.VTT.----...-...........--Avea..............................spktGRK...........................................................................................................................PKRP......................................................-RTIscdas..............................vpsiqaALDAVDAs.......aATEKDL....................................NP.LAPCGACNEWLLKIAE.....ANPSFKIVTFDSI.DCDSVYIHQ--ll...........
K4E1J4_TRYCR/369-492                 .............n-IVDLRKEPEGSFLSKLCPIIMSFr..qKNAHVSWRKKDpNRPVVTSLItyIDPEe..cDCQVDCSGRGRppalikpngrege...........ekhprstwctctrsFVLAVNYELSTPSGSRCSEQNALGK-LAS-----------------..............................------...---.--.---.----...-...........---.....................................---...........................................................................................................................----......................................................----.........................................-------.........------....................................--.----------------.....-------------.-----------mgl..........
A0A061J7V9_TRYRA/369-492             .............n-VVDLMREPEGSFILSVCPIIMSFr..qTHAHASWRKNDpNRPVVTSLItyIDPD....ECHCQADTGQRagspalmssgghkr.........qekyprntwctcnrsYVIAVNYELSTPSGSRCSEQNALGK-LAS-----------------..............................------...---.--.---.----...-...........---.....................................---...........................................................................................................................----......................................................----.........................................-------.........------....................................--.----------------.....-------------.-----------mgl..........
H3GUA2_PHYRM/361-650                 .............a-LTQMIVREMRMFRDQFLAAEGE-....GEVASFWLRKS.RKPVLAVLL..IEKP....AAVAGERPTIV......................................VQRGMNCEVSMPTGSLCAERNAIGSALASDPTLTRRALKMIAVLGL..............................NLSGSG...SNV.ISpTPS.ETRG...Sereg...gavgDDG.....................................NKKpseaqaaa...........................................................................................................gptfdqptS--Tstagptapalpvrirpacvqsspep....pdankpaerqgsvggvgrgrgrgrgKRAL.........................................ENKNANL.........TSPRKPkrprtfsfdeva...........veemmrasappdrNP.LAPCGACKEWLVKIAE.....ANPSFRVVTFENS.RCRNVYINQL-m............
X6N209_RETFI/83-179                  .............q-ITYLLIKEMEKYLKEFHAKERE-....DKMDPFWNRKS.FKSVLAVLM..VRKR....QDNDNNNNNNNnnnnn...........................nskqyvFYRGRNTEISLPVGSHCAERAAIVT---------------------..............................------...---.--.---.----...-...........---.....................................---...........................................................................................................................----......................................................----.........................................-------.........------....................................--.----------------.....-------------.-----------lcq..........
Q4Q0G6_LEIMA/534-603                 ..........aslg------------------------....-----------.---------..----....-----------......................................----------------------------------------------..............................------...---.--.---.----...-...........---.....................................--V...........................................................................................................................PTWG......................................................VREV.........................................FVHGM--.........-AATEP....................................NP.LFPCGVCENMLRRVTKdvlahYGGDVTLYMFDAT.TPRKIVFLPI-p............
W2PRR7_PHYPN/372-640                 .............a-MTQMIVREMRKFRDQFLAAEGE-....GEVAGFWLRKS.RKPVLAVLL..IEKP....AAELGGRPTIV......................................VQRGMNCEVSMPTGSLCAERNAIGSALASDPTLTRRALKMIAVLGL..............................NLTAGG...NIS.VT.SPT.ASED...T...........ADD.....................................KKE...........................................................................................................................PSDSatfdkktstavepansqvlpvrvrpt..avqssrssaavnnlsvddagrgrgrgKRAL.........................................ETKNANL.........TSPRKPkrprtfsfdeva...........veemmrasappdrNP.LAPCGACKEWLVKIAE.....ANPSFRVVTFENS.RCRNVYINQL-m............
#=GC seq_cons                        .............s.....hhp..ttahpphh.h........tpht..Wh++s.t+sVlsslh..lp.............s.........................................hhhuhNhElShPoGShCuEpNAlGp.lus......................................................................................................................................................................................................................................................................................................................................................................................tt.....................................NP.h.PCGsC.phL.+ltp......ssthhlhhFts..t.t.l......h............
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