GenomeNet

Database: Pfam
Entry: MCR_alpha_N
LinkDB: MCR_alpha_N
Original site: MCR_alpha_N 
#=GF ID   MCR_alpha_N
#=GF AC   PF02745.12
#=GF DE   Methyl-coenzyme M reductase alpha subunit, N-terminal domain
#=GF AU   Mian N, Bateman A, Griffiths-Jones SR
#=GF SE   Pfam-B_2706 (release 5.2)
#=GF GA   20.50 20.50;
#=GF TC   20.50 32.30;
#=GF NC   16.70 19.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   9367957
#=GF RT   Crystal structure of methyl-coenzyme M reductase: the key enzyme
#=GF RT   of biological methane formation 
#=GF RA   Ermler U, Grabarse W, Shima S, Goubeaud M, Thauer RK; 
#=GF RL   Science 1997;278:1457-1462.
#=GF DR   INTERPRO; IPR003183;
#=GF DR   SCOP; 1mro; fa;
#=GF CC   Methyl-coenzyme M reductase (MCR) is the enzyme responsible for 
#=GF CC   microbial formation of methane. It is a hexamer composed of 2
#=GF CC   alpha (this family), 2 beta (Pfam:PF02241), and 2 gamma
#=GF CC   (Pfam:PF02240) subunits with two identical nickel porphinoid
#=GF CC   active sites [1]. The N-terminal domain has a ferredoxin-like
#=GF CC   fold.
#=GF SQ   56
#=GS M4YK22_9EURY/5-269      AC M4YK22.1
#=GS Q8THH1_METAC/14-282     AC Q8THH1.1
#=GS MCRA_METBF/14-282       AC P07962.3
#=GS MCRA_METBF/14-282       DR PDB; 1E6Y D; 1014-4282;
#=GS MCRA_METBF/14-282       DR PDB; 1E6Y A; 1014-1282;
#=GS B8GE93_METPE/8-277      AC B8GE93.1
#=GS Q8TVA5_METKA/8-60       AC Q8TVA5.1
#=GS F6D2D3_METPW/3-268      AC F6D2D3.1
#=GS Q12TF8_METBU/14-283     AC Q12TF8.1
#=GS H1YXH9_9EURY/8-278      AC H1YXH9.1
#=GS MCRA_METKA/6-271        AC Q49605.2
#=GS MCRA_METKA/6-271        DR PDB; 1E6V A; 8-271;
#=GS MCRA_METKA/6-271        DR PDB; 1E6V D; 8-271;
#=GS L0L0H0_METHD/13-282     AC L0L0H0.1
#=GS A5ULM9_METS3/5-271      AC A5ULM9.1
#=GS U6EF81_9EURY/5-270      AC U6EF81.1
#=GS U6EEP1_9EURY/3-268      AC U6EEP1.1
#=GS MCRA_METTH/3-268        AC O27232.3
#=GS R9SLW2_9EURY/3-268      AC R9SLW2.1
#=GS A7I5T9_METB6/10-278     AC A7I5T9.1
#=GS E3GZ51_METFV/6-271      AC E3GZ51.1
#=GS R9TAZ9_9EURY/3-268      AC R9TAZ9.1
#=GS A3CSG1_METMJ/8-278      AC A3CSG1.1
#=GS D5VQU8_METIM/5-271      AC D5VQU8.1
#=GS K4MC35_9EURY/14-283     AC K4MC35.1
#=GS A0B6N6_METTP/7-276      AC A0B6N6.1
#=GS Q6LWZ5_METMP/5-272      AC Q6LWZ5.1
#=GS MCRX_METFV/6-272        AC Q49174.2
#=GS A6UWH2_META3/5-271      AC A6UWH2.1
#=GS F4BXY1_METCG/7-276      AC F4BXY1.1
#=GS MCRX_METTH/4-271        AC P21110.3
#=GS MCRA_METJA/5-271        AC Q58256.2
#=GS E1RDX4_METP4/8-278      AC E1RDX4.1
#=GS F0T8R3_METLA/3-268      AC F0T8R3.1
#=GS A0A0A7LF46_9EURY/7-271  AC A0A0A7LF46.1
#=GS Q0W339_METAR/7-274      AC Q0W339.1
#=GS A2SSD1_METLZ/8-278      AC A2SSD1.1
#=GS MCRX_METJA/5-271        AC Q60391.1
#=GS E1RJD5_METP4/8-278      AC E1RJD5.1
#=GS Q2NHZ8_METST/5-271      AC Q2NHZ8.1
#=GS M9SBG6_9EURY/7-271      AC M9SBG6.1
#=GS L0HD22_METFS/10-280     AC L0HD22.1
#=GS D7DUH5_METV3/5-272      AC D7DUH5.1
#=GS D1YVW6_METPS/7-275      AC D1YVW6.1
#=GS A5ULZ2_METS3/3-268      AC A5ULZ2.1
#=GS L0HIJ7_METFS/11-279     AC L0HIJ7.1
#=GS J0RY59_9EURY/8-278      AC J0RY59.1
#=GS A2STR9_METLZ/8-278      AC A2STR9.1
#=GS G7WN24_METH6/7-276      AC G7WN24.1
#=GS J0SAE9_9EURY/8-278      AC J0SAE9.1
#=GS F7XL13_METZD/14-283     AC F7XL13.1
#=GS D3E050_METRM/3-268      AC D3E050.1
#=GS A3CT46_METMJ/8-278      AC A3CT46.1
#=GS F6BE97_METIK/5-271      AC F6BE97.1
#=GS Q8PXH8_METMA/14-282     AC Q8PXH8.1
#=GS D7E8X7_METEZ/15-284     AC D7E8X7.1
#=GS F6BBJ2_METIK/5-270      AC F6BBJ2.1
#=GS F0TCV5_METLA/5-270      AC F0TCV5.1
#=GS Q2FSN0_METHJ/8-277      AC Q2FSN0.1
#=GS D5EAD6_METMS/14-284     AC D5EAD6.1
M4YK22_9EURY/5-269                 ..EKLFLEACKK.KFK-E.EPTSMETKYYCYGGWKQSKSKVEFQKEAMEI.AKKR..GFPMMNEDV---.GVPLGQRSWMPYQLSHT.DIFVEPDDLHCINNPAIQQAWDDIRRTVLVGLDSPHQTIEKRLGKEVTPETINAYLEAVNHTIPGGAIVQEHMAECNPALVYDSYVKVFSGNDELIDEIDPRFVIDINKNFPKDQAEKLKKAMGKTVMQAVRVPTMVGRVMDGATVSRHAAMQISMSFISSYKLAAGEAAIADFAYSAKHLS-INMGTMMP...............
Q8THH1_METAC/14-282                .e-VKFTQEYGS.NKQAGgDITGKTEKF-LRLGPEQDARKQEMIKAGKEI.AEKR..GIAFYNP-MMHM.GAPLGQRAITPYTISGT.DIVAEPDDLHYVNNAAMQQMWDDIRRTCIVGLDMAHETLEKRLGKEVTPETINHYLETLNHAMPGAAVVQEMMVETHPALVDDCYVKIFTGDDELADEIDKQYVINVNKMFSEEQAAQIKASIGKTTWQAIHIPTIVSRTTDGAQTSRWAAMQIGMSFISAYAMCAGEAAVADLSFAAKHAALVSMGEMLP...............
MCRA_METBF/14-282                  .e-VKFAQEFGS.NKQTGgDITDKTAKF-LRLGPEQDPRKVEMIKAGKEI.AEKR..GIAFYNP-MMHS.GAPLGQRAITPYTISGT.DIVCEPDDLHYVNNAAMQQMWDDIRRTCIVGLDMAHETLEKRLGKEVTPETINHYLEVLNHAMPGAAVVQEMMVETHPALVDDCYVKVFTGDDALADEIDKQFLIDINKEFSEEQAAQIKASIGKTSWQAIHIPTIVSRTTDGAQTSRWAAMQIGMSFISAYAMCAGEAAVADLSFAAKHAALVSMGEMLP...............
#=GR MCRA_METBF/14-282       SS    .H-HTS--TT--.----TT-SEE------GGGSHHHHHHHHHHHHHHHHH.S---..GGSSSS---SS-.--EEBTTS--EE-GGGG.GGG-HHHHHHHHHHHTEEEEESHHHHHHHHHHH-----HHHHHHHHHHHHHHTTT--SS-SS-----GGGSTT-EEEEEES-HHHHTTS-GGGB--HHHHS-HHHHHHHHHHH-S-EEEEEE--HHHHHHS-TTHHHHHHHHHHHHHHHHHTT--TT-HHHHHHHHHHHTTTEE-SS--B-XXXXXXXXXX...............
B8GE93_METPE/8-277                 ..QKLFLKALKE.KFAGE.DPAGEHTHF-ARAGLEQSERKREFMKEGKKV.EMER..GISQYDPKRCHLgGIPLGQRQLMTYEISGT.GTFVEGDDLHFVNNAAMQQMWDDIRRTIIVGMDLAHNTLQKRLGKEVTPETINEYLHILNHAMPGAAVVQEHMVETHPSLVSDCYVKVFTGDDEVADQIEPQYLLNIEKLFPAKSAEKLKAAVGKSMFQAIHIPTTVSRTCDGGTTSRWSAMQIGMSFIAAYRMCAGEAAVADLSYAAKHAGVIQMADILP...............
Q8TVA5_METKA/8-60                  .e-ALFIKALKE.KFE-E.DPEEKHTKFYVYGGYRQSPRKE-FA------.----..------------.-----------------.-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------kgalrefepagerdl
F6D2D3_METPW/3-268                 ..DKKFIDALNK.KFK-E.DPEEKKTTFYSFGGWKQSERKREFVEAGKKI.AAER..GIPQYNPDV---.GTPLGQRVLMPYQVSTT.DTFVEGDDLHFVNNAAMQQMWDDIRRTVIVGLDTAHNVIEKRLGKEVTPETITHYLETVNHAMPGAAVVQEHMVETNPALVADSYVKVFTGNDEIADEIDSAYVLDINKMFPEEQAEVLKAEVGDGIWQAVRIPTIVSRTCDGGTTSRWSAMQIGMSMISAYKQCAGEAATGDFAFAAKHAAVIHMGTALP...............
Q12TF8_METBU/14-283                .e-IKFTKAHGD.NKMEGgEITDKKVTYY-RLGVDQNPRKVEMRKAGQEI.ADKR..GLVGYNP-MMHCgGIPLGQRALTPSFISGT.DIMVESDDLHYVNNAAMQQMWDDIRRTTIVGMDMAHETLEKRLGIEVTPETINHYLEVLNHALPGGAVVQEHMVETHPALVDDCYCKIFTGDDELADEIDDQFLININKQFPEEQAEALKAAIGKTTWQAAHIPTIVSRTTDGAQTSRWMAMQVGMSFIAAYNMCAGEAAVADLSYAAKHAGVISMGDMLP...............
H1YXH9_9EURY/8-278                 ..QKLFLDALKQ.KFQGE.DVESVKTTFYNFDGVRQSPRKREFMEATKAV.EAKR..GMAMYDPEHCHLgGLPMGQRQLMTYEVSGT.GTFVEGDDLHFVNNAAMQQFWDNIRRTVIVGMDLAHATLQKRLGKEVTPETINEYLHILNHAMPGAAVVQEHMVETHPGLVDDCYVKVFTGDDEMADDIEPQFLINVEKLFPAEQAEVLKAEVGKSMYQAIHIPTIVSRTCDGGTTSRWSAMQIGMSFIAAYRMCAGEAAVADLSFAAKHAGVVQMASHLP...............
MCRA_METKA/6-271                   ..EKLFMKALKE.KFE-E.SPEEKYTKFYIFGGWKQSERKKEFKEWADKI.VEER..GVPHYNPDI---.GVPLGQRKLMSYQVSGT.DVFVEGDDLHFVNNAAMQQMWDDIRRTVIVGMDTAHRVLERRLGKEVTPETINEYMETLNHALPGGAVVQEHMVEIHPGLTWDCYAKIITGDLELADEIDDKFLIDIEKLFPEEQAEQLIKAIGNRTYQVCRMPTIVGHVCDGATMYRWAAMQIAMSFICAYKIAAGEAAVSDFAFASKHAEVINMGEMLP...............
#=GR MCRA_METKA/6-271        SS    ..--HHHHHHH-.S-T--.B---S-S-GGGG-HHHHHHHHHHHHHHHHH-.----..SS--S-SS----.EBTTS--EEEGGGSSGG.-HHHHHHHHHHHTEEEEE-HHHHHHHHHTT-----HHHHHHHHHHHHHHTTT--SS-TT-----TTT-TT-EEEEEES-HHHHTTS-GGGB--HHHHS-HHHHHHHHHHH-S-EEEEEE--HHHHHHS-HHHHHHHHHHHHHHHHHHHHT--SS-TTHHHHHHHHHTTSEEES---B-XXXXXXXXXXXXX...............
L0L0H0_METHD/13-282                ei--KFTKEHGAnKMEGG.KITDMVGKYY-RLGVDQNPRKVEMKKAGQEL.AKKR..GLVGYNP-MMHCgGIPLGQRALTPSFISGT.DMMVEVDDLHYVNNAAMQQMWDDIRRTCIVGIDLAHETLEKRLGIEVTPETINFYLETLNHALPGGAVVQEHMVETHPALVDDCYCKIFTGDDELADEIDKQFLIDINKEFPEEQAAQIKAAIGKTTWQAAHIPTVVSRVTDGAQTTRWMAMQVGMSFISAYSMCAGEAAVADLSYAAKHAGVISMGEMLP...............
A5ULM9_METS3/5-271                 ..EKVFFKALNQ.KFKGE.DNESNHTSFYCFDGWKQSPRKREFNDAAEKL.AKDR..NMPFYNPDI---.GVPLGQRSLMTYKISGT.DDYVEGDDLHFCNNAAIQQLVDDIKRTIIVGMDTAHSVLQERLGVEVTPETINEYMENINHALPGGAVVQEHMVEVHPGLVSDCYAKIFTGNDELADEIDKRVLIDINKEFPEDQAQMLKDYLGNKTYQVSRVPTLVVRACDGGTVSRWSAMQIGMSFINAYKLCAGEAAIADFSYAAKHADVIGMASFLP...............
U6EF81_9EURY/5-270                 ..KKLFLKALQN.KFD-E.DPKQNHTNFYCFGGWKQSPRKKEFDEFAKKI.EEDR..GIPFYNPDI---.GVPLGQRKLMAYKVSGT.DTYVEGDDLHFCNNAAIQQLNDDIKRTIIVGMDTAHSVLEKRLGVEVTPETINEYMETINHALPGGAVVQEHMVEVHPGLVGDCYAKLFTGDDSLADELDSRYLIDINKEFPEEQAKQLKEYIGNKTYQISRVPSLVVRVCDGGTVSRWSAMQIGMSFIAAYKLCAGEAAIADFSYAAKHADVISMGSILP...............
U6EEP1_9EURY/3-268                 ..EKMFINALKK.AFE-E.DPSDKTTTFYKFGGWRQSERKREFVEAGKEV.AAKR..GIPQYDPDV---.GTPLGQRVLMPYQVSTT.DTFVEGDDLHFVNNAAMQQFWDDIRRTVIVGLNTAHSVIEKRLGKEVTPETITHYLETVNHAMPGAAVVQEHMVETHPLLTADSYVKVFTGNDEIADEIDQRYVLDINEEFPEHQAEVLKAEVGDGMWTVVRIPTIVSRTCDGGTTSRWSAMQVGMSMISAYKQAAGEAATGDFAYAAKHAEVIHMGTYLP...............
MCRA_METTH/3-268                   ..DKLFINALKK.KFE-E.SPEEKKTTFYTLGGWKQSERKTEFVNAGKEV.AAKR..GIPQYNPDI---.GTPLGQRVLMPYQVSTT.DTFVEGDDLHFVNNAAMQQMWDDIRRTVIVGLNHAHAVIEKRLGKEVTPETITHYLETVNHAMPGAAVVQEHMVETHPALVADSYVKVFTGNDEIADEIDPAFVIDINKQFPEDQAETLKAEVGDGIWQVVRIPTIVSRTCDGATTSRWSAMQIGMSMISAYKQAAGEAATGDFAYAAKHAEVIHMGTYLP...............
R9SLW2_9EURY/3-268                 ..DKKFYEALNK.KFK-E.SPEDKTTTFYNLGGWKQSERKTQFYEAGKEI.AEER..GIPMYNPDI---.GSPLGQRTLMPYQLSTT.DTFVEGDDLHFINNAAIQQLWDDIRRTVLVGLNTAHNVLQRRLGMEVTPETITNYLETVNHAMPGAAVVQEHMVETNPYLVSDSYVKIFTGDDELADEIDQCYVLDINKEFPDDQAAQLKAEVGDKIWQVVRVPSLVGRVCDGGTTSRWSAMQIGMSMISAYNQCAGEGATGDFAFATKHAEVIQMGAPLP...............
A7I5T9_METB6/10-278                ..QKLFLKAMKE.KFA-E.DPQATSTVF-ARAGLEQSPRKMEFLKEGQKV.ALDR..GISMYDPKRCHCgGIPLGQRQLMTYEVSGT.GVFVEGDDLHFVNNAAMQQMWDDIRRTIIVSLDLAHGTLQKRLGKEVTPETINEYLHVLNHAMPGAAVVQEHMVETHPALVDDCYVKIFTGDDEMADDIEPQFVLNLDKLFPAKQAAALKAAVGKSMWQAVHIPTTVSRTCDGGTTSRWSAMQIGMSFIGAYKMCAGEAAVSDLAFAAKHAGVIQMADILP...............
E3GZ51_METFV/6-271                 ..KKLFVDALRK.KFK-E.EPKERKTTFYTLGGWKQSERKKEFVEYGKKV.AKER..GIPAYNPDI---.GTPLGQRVLMPYQVSTT.DTFVEGDDLHFVNNAAMQQFWDDIRRTVIVGLNHAHRILERRLGKEVTPETINHYLETVNHAMPGAAVVQEHMVETHPGLTADSYVKVFTGNDELADEIESCYLIDINKQFPEHQAEQLKKAIGDSIWQAVRIPTIVSRTCDGATTSRWSAMQIGMSMISAYKQAAGEAATADFAYAAKHAEVIHLGTFLP...............
R9TAZ9_9EURY/3-268                 ..DKLFMDAMKK.KFK-E.DPTDEYTSYYTFGGWKQSKRKREWVEQANAI.AKAR..GIPMMNQDI---.GVPLGQRVLMPYQLSHT.DMYAEADDLHFVNNAAIQQAWDDIRRTVIVGLDTAHTVIEKRLGKEVTPETINNYLETVNHAMPGGAVVQEHMAECSPALTADCYVKVFSGNSELIDQLDKRFVIDINKEFPEDQAKQLNDAIGKSLYQVVRCPTIVGRVCDGGTMSRWSAMQISMSFISAYRLAAGEAAIADFAYAAKHASVVEMGTMMP...............
A3CSG1_METMJ/8-278                 ..QKLFLKALKE.KFQGQ.DVESETAEFYNFNGVRQSPRKMEFMKASRAV.EMDR..GISMYDPERCHLgGIPMGQRQLMTYEVSGT.GVFVEGDDLHFVNNSAMQQMWDDIRRTVIVGMDLAHQTLQKRLGKEVTPETINEYLHILNHAMPGGAVVQEHMVETHPGLVDDCYVKVFTGDQELADDIEPQFLLNIEKLFPAKQAEELKAEVGKSMYQAIHIPTAVSRTCDGGTTSRWSAMQIGMSFIAAYRMCAGEAAVADLSYAAKHAGVVQMGSILP...............
D5VQU8_METIM/5-271                 .k-RLFLKALKE.KFE-E.DPREKYTKFYIFGGWRQSARKREFVEAAQKL.IEKR.gGIPFYNPDI---.GVPLGQRKLMPYKVSNT.DAIVEGDDLHFMNNAAIQQMWDDIRRTVIVGMDTAHAVLEKRLGVEATPETINEYMEVINHALPGGAVVQEHMVEVHPALVWDCYAKIFTGDDELADEIDKRFLIDINKLFPEEQAEQIKKAIGKRTYQVSRVPTLVGRVCDGGTIARWSAMQIGMSFITAYKLCAGEAAIADFSYAAKHADVIQMATFLP...............
K4MC35_9EURY/14-283                ei--KFTKEHGSnKMQGG.EITDMVGKYY-RLGVEQNPRKVEMKKAGQEI.AKKR..GLVGYNP-MMHCgGIPLGQRALTPSFISGT.DMMVEIDDLHYVNNAAMQQMWDDIRRTVVVGMDMAHETLEKRLGIEVTPETINHYLETLNHALPGGAVVQEHMVETHPALVDDCYVKVFTGDDELADEIDKQFLIDINKQFPAEQAETIKAAIGKTSWQAAHIPTIVSRVTDGAQTSRWMAMQVGMSFISAYSMCAGEAAVADLSYAAKHAGVLSMGEMLP...............
A0B6N6_METTP/7-276                 ..KKLFVRALTK.KFGKDfDLSSQKTEY-KRLGPEQSARKREFMEYSKKL.EGKR..GISFYNP-YLHCgGVPLGQRQLVPYKLSNT.EYIVEGDDLHFVNNPAMQQMWDDIRRTVVVGLDMAHEVLEKRLGKEVTPETINNYLEILNHAMPGAAVVQEHMVETHPGLVEDCNVRVFTGDDDLADEIDPQYLIDINKLFPADQAEQLKAAIGKTTWQAIHIPTIVVRSCDGGTTSRWSAMQLSMTFIDAYNMCAGEAAVADLAYAAKHAAVLQMSDMLP...............
Q6LWZ5_METMP/5-272                 .k-RLFLKALKE.KFE-E.DPKEKYTKFYTFGGWEQSARKREFVEANEKI.VSEKrqGIPLYNPDI---.GVPLGQRKLMPYKLSNT.DDYCEGDDLHFLNNAAIQQLWDDIRRTVIVGMDTAHSVLEKRLGVEVTPETINEYMHTINHSLPGGAVVQEHMVEVHPSLAWDCYARIFTGDDELADELDSRFLIDINKLFPEEQAETLKAAIGKKTYQVSRVPSLVGRVCDGGTISRWSAMQIGMSFITAYKLCAGEAATADFSYASKHADVIQMGNALP...............
MCRX_METFV/6-272                   ..KKLFLEALEK.KFKGE.SPEEKKTTFYCFGGWKQSERKREFVEYAKKL.AKKR..GIPFYNPDI---.GVPLGQRKLMAYRISGT.DAYVEGDDLHFVNNAAIQQMVDDIKRTVIVGMDTAHAVLEKRLGVEVTPETINEYMETINHALPGGAVVQEHMVEVHPGLVDDCYAKIFTGNDELADELDKRVLIDINKEFPEEQAEMLKKYIGNRTYQVNRVPTIVVRCCDGGTVSRWSAMQIGMSFISAYKLCAGEAAIADFSFAAKHADVIEMGTILP...............
A6UWH2_META3/5-271                 ..KKLFLKALKE.KFD-E.DPKEKYTKFYTYGGWKQSKRKTEFVEAAKDI.ADKR.gGMPGYNPDI---.GVPLGQRKMMSYKLSGT.DDYVEGDDLHFMNNAAIQQLHDDIRRTVIVGMDTGHMVLEKRLGVEVTPETINEYMETINHALPGGAVVQEHMVEVDPALAWDSYAKIFTGDDELADELDKRVLVDINKLFPEEQAEELKAAIGKKTYQISRVPTLVGRVCDGGTIARWSAMQIGMSFITAYKLCAGEAAIADFSYAAKHADVIGMGTALP...............
F4BXY1_METCG/7-276                 ..KKLFVKALNK.KFGKDfDLASQKVEY-KRLGPEQNARKREFMEYAKKL.EGKR..GMTGYNP-YVHAgGIPLGQRQLVPYKLSST.EYVVEGDDLHFVNNPAMQQFWDDIRRTIVVGLDMAHEVLQKRLGKEVTPETINNYLEILNHAMPGAAVVQEHMVETHPGLVDDCNVRVFSGDDALADEIDDQYKIDINKMFPEDQAETLKAAIGKTTWQAIHVPTIVVRTCDGGTTSRWSAMQLCMTFIDAYNMCAGEAAVADLAYAAKHAAVLQMSDMLP...............
MCRX_METTH/4-271                   ..KKLFLTALKK.KFEVE.DPDEKYTNFYCFGGWEQSARKKEFTEYAKKA.AEKR.gGIPFYNPDI---.GVPLGQRKLMAYRVSGT.DAYVEGDDLHFVNNAAIQQMVDDIKRTVIVGMDTAHAVLEKRLGVEVTPETINEYMEAINHALPGGAVVQEHMVEVHPGLVEDCYAKIFTGDDNLADELDKRILIDINKEFPEEQAEQLKSYIGNRTYQVNRVPTIVVRTCDGGTVSRWSAMQIGMSFISAYKLCAGEAAIADFSYAAKHADVIEMGTIMP...............
MCRA_METJA/5-271                   .k-RLFLKALKE.KFE-E.DPREKYTKFYVFGGWRQSARKREFVEAAQKL.IEKR.gGIPFYNPDI---.GVPLGQRKLMPYKVSNT.DAIVEGDDLHFMNNAAMQQFWDDIRRTVIVGMDTAHAVLEKRLGVEVTPETINEYMETINHALPGGAVVQEHMVEVHPALVWDCYAKIFTGDDELADEIDKRFLIDINKLFPEEQAEQIKKAIGKRTYQVSRVPTLVGRVCDGGTIARWSAMQIGMSFITAYKLCAGEAAIADFSYAAKHADVIQMASFLP...............
E1RDX4_METP4/8-278                 ..QKLFLNALKE.KFQGE.DPESVKTTFYNFDGVRQSPRKREFMAEAKKV.EMKR..GISMYDPEHCHLgGLPMGQRQLMTYQVSQT.DVFVEGDDLHFVNNAAMQQMWDDIRRTVIVGMDLAHATLQKRLGKEVTPETINEYLHILNHAMPGGAVVQEHMVETHPGIVDDCYVKVFTGDDEMADDIEPQFLLNVDKLFNAEQAEVLKKQVGKSMYQAIHIPTIVSRTCDGGTTSRWSAMQIGMSFIAAYRMCAGEAAVADLSFAAKHAGVIQMATHLP...............
F0T8R3_METLA/3-268                 ..EKMFIDALKK.AFK-E.DPTDDKTTFYNKGGWKQSERKREFVAAGKDI.AAKR..GIPMYDPDV---.GTPLGQRVLMPYQVSTT.DTFVEGDDLHFVNNAAMQQFWDDIRRTVIVGMNTAHMVIEKRLGKEVSPETITNYLETVNHAMPGAAVVQEHMVETNPYLVADSYVKTFTGNDEIADEIDPAYVLNINKMFNEEQAEVLKAEVGDGIWQVVRIPTIVSRTCDGGTTSRWSAMQIGMSMISAYKQAAGEAATGDFAYAAKHAEVVHMGTALP...............
A0A0A7LF46_9EURY/7-271             ..DKLFMDAVKK.KFK-E.DPTDMETKYYCYGGWRQSKSKVEFQKAAQAI.AKKR..GFPMMNEDI---.GVPLGQRAWMPYQLSHT.DIYVEVDDLHCINNPAIQQAWDDIRRTILVGLNSPHETIEKRLGKEVTPETINNYLEAVNHTMPGGAIVQEHMAECNPALVSDSYVKVYSGDDELIDEIDKRFVIDINKLFPKAQADQLKKAIGKNLMQAVRVPTMVGRLMDGATVSRHAAMQISMAFISSYKLAAGEAAIADFAYSAKHLS-INMGTMMP...............
Q0W339_METAR/7-274                 ..QKRFIKAMKK.KFA-E.EPTAQVTKF-KYEGYTQSKRKVEFKKTGDAI.AKKR..GISMYNP-MVHMgGIPLGQRQLMNYVVSGT.DIAVEGDDLHFVNNAAMQQFWDEIRRTVIVGLDTAHATLEKRLGKTVTPETISNYLAVLNHAMPGAAVVQEHMVETHPGLTDDCFVKVFTGDDELADSIDKQYVLDINKAFPKEQAAQLKKAIGKQLFQAVHIPTIVVRTCDGGTTSRWSAMQIGMSFIDAYKMCAGEAAVADLAFAAKHASVVEMGNLLP...............
A2SSD1_METLZ/8-278                 ..QKLFLDALKQ.KFPKQ.DVASVQTEFYKFNGVQQSPRKREFMAENKKI.EAAR..GISMYDPEHCHLgGIPMGQRQLMTYEVSGT.GTFVEGDDLHFVNNAAMQQMWDDIRRTVIVSMDMAHQTLQKRLGKEVTPETINEYLHVVNHAMPGGAVVQEHMVETHPGLTDDCYVRVFTGDQELADNLEPQFVIDVEKLFPKKQAEALQAAVGKSLWQCVHMPTIVGRTCDGGTTSRWSAMQIGMSFIAAYRMCAGEAAVADLSFAAKHAGVINMAHHLP...............
MCRX_METJA/5-271                   ..KKLFLKALKE.KFE-E.DPKEKYTKFYIFGGWRQSARKREFVEFAQKL.IEKR.gGIPFYNPDI---.GVPLGQRKLMTYKISGT.DAFVEGDDLHFCNNAAIQQLVDDIKRTVIVGMDTAHAVLEKRLGVEVTPETINEYMETINHALPGGAVVQEHMVEVHPGLVWDCYAKIFTGNDELADEIDKRFLIDINKEFPEEQAEQIKKYIGNRTYQVSRVPTIVVRCCDGGTVSRWSAMQIGMSFITAYKLCAGEAAIADFSYAAKHADVIQMGMILP...............
E1RJD5_METP4/8-278                 ..QKLFLNALKE.KFQGQ.DIESERTTFYNFDGVRQSPRKREFMAETVEI.EKKR..GISMYDPERCHLgGIPMGQRQLMTYEVSGT.NTFVEGDDLHFVNNAAMQQMWDEIRRTVIVGMDMAHATLQKRLGKEVTPETINEYLHILNHAMPGGAVVQEHMVETHPALTDDCFVKVFTGDDELADDIDPQYLINIDKLFPENQAAELKEEVGKSIFQAIHIPTIVSRTCDGGTTSRWSAMQIGMSFIAAYRMCAGEAAVADLSFAAKHAGVIQMGTILP...............
Q2NHZ8_METST/5-271                 ..KKLFLKALKE.KFD-E.DPEEENTKFYCYGGWEQSARKREFAEEAEKA.VEAR.gGLPFYNPDI---.GVPLGQRKLMAYQVSGT.DTYVEGDDLHFCNNSAIQQLVDDIKRTVIVGMDTAHGVLEQRLGVEVTPETINEYLETINHALPGGAVVQEHMVEVDPGLVTDSYAKIFTGDDDLLDQLDQRFVIDINKEFPEEQAEMLKKYIGKKTYQVSRVPTLVVRACDGGTTSRWSAMQIGMSFISAYKLCAGEAAIADFSYAAKHADVISMASAMP...............
M9SBG6_9EURY/7-271                 ..EKLFLEACKK.KFK-E.DPTSMETKYYCYGGWKQSKSKVEFQKEAMEI.AKKR..GFPMMNEDI---.GVPLGQRSWMPYQLSHT.DIFVEPDDLHCINNPAIQQAWDDIRRTVLVGLDSPHQTIERRLGKEVTPETINAYLETVNHTMPGGAVVQEHMAECNPALVYDSYVKVFSGDDELIDELDPRFVIDINKNFPKDQAEKLKKAIGKTVMQAVRVPTMVGRVMDGATVSRHAAMQISMAFISSYKLAAGEAAIADFAYSAKHMS-INMGSMMP...............
L0HD22_METFS/10-280                ..QKQFLKALKE.KFKGQ.DVESQKTGFYKFGGVQQSPRKREFMAATKKI.EADR..GISMYDPEHCHLnGIPMGQRQLMTYEVSGT.GTFVEGDDLHYVNNSAIQQMSDEIKRTIIVGMDIAHNTLQKRLGKEVTPQTINEYLHILNHAMPGGAVVQEHMVETNPGLVDDCYVKIFTGNDEVADDIEPQYLLNIEKLFPKKQAEALKAEIGKSMYQAIHVPTIVVRTCDGGTTSRWSAMQIGMSFIAAYRTCAGEAAVADLSFAAKHAGVIQMGSHLP...............
D7DUH5_METV3/5-272                 .k-RLFLKALKE.KFE-E.DPKEKFTKFYTYGGWQQSERKKEFFAENERIvAEKR.dGIPMYNPDI---.GVPLGQRKLMPYKVSNT.DSYVEGDDLHFMNNAAIQQLWDDIRRTVIVGMDTAHMVLEKRLGVEVTPETINEYMHTINHSLPGGAVVQEHMVEVHPSLAWDCYAKIFTGDDELADELDDRFVININKLFPEEQAEELKAAIGKKTYQVSRVPSLVGRVCDGGTISRWSAMQIGMSFITAYKLCAGEAAIADFSYAAKHADVIQMGNALP...............
D1YVW6_METPS/7-275                 ..QKRFIKAMKK.KFAGE.DPTSTTTVY-KYEGYTQSKRKVEFKKAGDAI.AKKR..GISAYNP-MVHMgGIPLGQRQLTPYVVSGT.DVVVEGDDLHFVNNAAMQQFWDEIRRTVIVGLDTAHATLEKRLGKTVTPETISNYLAILNHAMPGAAVVQEHMVETNPALTDDCFVKVFTGDDELADSIDKQYVLDINKAFPKDQAAALKKAVGKSLYQAVHIPTTVVRTCDGGTTSRWSAMQIGMSFIDAYKMCAGEAAVADLAFAAKHASLVEMADILP...............
A5ULZ2_METS3/3-268                 ..DKKFLDAMKN.KFS-E.GPTDKRTTFYNMGGWKQSERKSAFVKEGKEI.AEKR..GIPMYNPDI---.GTPLGQRALMSYQLSTT.DTYVEGDDLHFINNAAIQQAWDDIRRTVIVGLNTAHNVLEKRLGIEVTPETITEYLETVNHAMPGAAVVQEHMVETDPLVVQDSYVKVFTGDDELADEIDSAFVLDINKEFNEEQAAALKEEVGGSVWQAVRIPAIVGRVCDGGTTSRWSAMQIGMSMISAYNQCAGEGATGDFAYASKHAEVIHMGTYLP...............
L0HIJ7_METFS/11-279                ..QKLFLKAMKE.KFA-E.DPQAQATVF-KREGLSQSPRKMEFVKAGKAA.EMDR..GISMYDPARCHCgGIPLGQRQLMTYEISST.GVFVEGDDCHFVNNAAMQQMWDDIRRTIIVGLDLAHGTLQKRLGKEVTPETINEYLHVLNHAMPGAAVVQEHMVETHPSLVDDCYVKVFTGDDEMADDLEPQFVLNVDKLFPAKQAAQLKAAVGKSMWQAVHIPTIVSRTCDGGTTSRWSAMQIGMSFIGAYKMCAGEAAVADLAFAAKHAGVIQMADILP...............
J0RY59_9EURY/8-278                 ..QKLFLKALKE.KFQGQ.DVQSEKAEFYKFGGLKQSPRKQEFLKESRAV.EMQR..GISMYDPERCHLgGIPMGQRQLMTYEVSGT.GVFVEGDDLHFVNNAAMQQFWDDIRRTIIVGMDLAHATLQKRLGKEVTPETINEYLHILNHAMPGAAVVQEHMVETHPALTDDCYVKVFTGDDELADDIEPQFLLNIEKLFPAKSAEALKAAVGKSMFQAVHIPTIVSRTCDGGTTSRWSAMQLGMSYIAAYRMCAGEAAVADLSYAAKHAGVIQMADILP...............
A2STR9_METLZ/8-278                 ..QKLFLDALKQ.KFPKQ.DVASTTAEFYKFNGLEQSPRKREFMAENKKI.EAAR..GISMYDPNRCHLgGIPMGQRQLMTYELSGT.GTFVEGDDLHFVNNAAMQQMWDDIRRTVIVSMDMAHQTLQKRLGKEVTPETINEYLHVVNHAMPGGAVVQEHMVETHPGLTDDCYVRVFTGDQELADNLEPQFVIDVEKLFPKKQAEALQAAVGKSLWQCVHMPTIVGRTCDGGTTSRWSAMQIGMSFIAAYRMCAGEAAVADLSFAAKHAGVINMAHHLP...............
G7WN24_METH6/7-276                 ..KKLFVKALNK.KFGRDfDLSGTKTVY-ERLGPEQNARKREFMEASKKL.EGKR..GISMYNP-YLHAgGVPLGQRQLVPYKLSTT.EYIVEGDDLHFVNNPAMQQMWDDIRRTIVVGLDMAHEVLEKRLGKEVTPETINNYLEILNHAMPGAAVVQEHMVETHPALVDDCNVRMFTGDDDLADEIDDQYLIDVNKLFPAEQAEEIKAAMGKTSWQAIHIPTIVSRTCDGGTTSRWSAMQLSMTFIDAYNMCAGEAAVADLAFAAKHAAVIQMADMLP...............
J0SAE9_9EURY/8-278                 ..QKLFLKALKE.KFQGQ.DVQSEKTEFYKFGGVRQSQRKLEFMKESRSI.EMQR..GISMYDPERCHLgGIPMGQRQLMTYEVSGT.GVFVEGDDLHFVNNSAMQQMWDEIRRTVIVGMDMAHATLQKRLGKEVTPETINEYLHILNHAMPGGAVVQEHMVETHPALTDDCYVKVFTGDDELADEIDAQYLINIEKLFPKKQAEELKAEVGKSMFQAIHIPSIVSRTCDGGTTSRWSAMQIGMSFIAAYRMCAGEAAVADLSYAAKHAGVIQMGSILP...............
F7XL13_METZD/14-283                .e-IKFTKEFGD.NKQSGgSITDTRNKY-HRLGVDQDPRKREMREAGQKV.AKER..GLVGYNP-MMHCgGIPLGQRAITPSFVSGT.DIMVEPDDLHYVNNAAMQQMWDDIRRTCIVGLDMAHETLEKRLGMEVTPETINHYLEVLNHALPGGAVVQEYMVETHPALVDDCYVKIFTGDDDLADEIDKQFLIDINKEFPEEQAEQLKKSIGKTTWQAAHIPTIVSRTTDGGQTSRWIAMQVGMSFISAYNMCAGEAAVADLSYSAKHAAVVSMGDMLP...............
D3E050_METRM/3-268                 ..DKKFLDAMTK.KFK-E.APEEKTTTFYNMGGWTQSERKTEFVNEGKAI.AEAR..GIPMYNPDI---.GNPLGQRALMSYQLSGT.DTFVEGDDLHFINNAAMQQAWDDIRKTVIVGLNTAHNVLEKRLGMEVTPETITNYLEVVNHAMPGAAAVQEHMVETNPLLVDDSYVKVFTGDDDLAAEIDPAFVLDINKEFPEEQAEALKAEVGGAIWQIVRVPSVVGRVCDGGTTSRWSAMQIGMSMISAYGQCAGEGATGDFAYASKHAEVIGMGTYLP...............
A3CT46_METMJ/8-278                 ..QKLFLKSLKE.KFQGQ.DVESETTEFYKFNGYHQSPRKEEFVKASRAV.EMDR..GISMYDPVRCHLgGIPLGQRQLMTYEVSGT.GVFVEGDDLHFVNNAAMQQMWDDIRRTVIVNMDLAHQTLQKRLGKEVTPETINEYLHVLNHAMPGAAVVQEHMVETHPGLVDDCYVKVFTGDQELADDLEPQFVLDVEKLFPAKQAEALSAAVGKSLWQAIHIPTTVSRTCDGGTTSRWSAMQIGMSFIGAYRMCAGEAAVADLSYAAKHAGVIQMASHLP...............
F6BE97_METIK/5-271                 ..KKLFLKALKE.KFE-E.DPKEKYTKFYVFGGWKQSARKREFVEAAEKL.LEKR.gGIPFYNPDI---.GVPLGQRKLMPYKLSGT.DYIVEGDDLHFMNNAAMQQMWDDIRRTVIVGMDTAHAVLEKRLGVEVTPETINEYMETINHALPGGAVVQEHMVEVHPALAWDCYAKIFTGDDELADEIDKKFLIDINKLFPEEQAEQIKKAIGKRTYQVNRVPTLVGRVCDGGTIARWSAMQIGMSFITAYKLCAGEAAIADFSYAAKHADVIQMGTLLP...............
Q8PXH8_METMA/14-282                .e-VKFTQEYGS.NQQAGgDITGKTAKF-LRLGPEQDARKAEMIKAGKEI.AEKR..GIAFYNP-MMHS.GAPLGQRAITPYTLSGT.DIVAEPDDLHYVNNAAMQQMWDDIRRTCIVGLDMAHETLEKRLGKEVTPETINHYLEVLNHAMPGAAVVQEMMVETHPALVDDCYVKVFTGDDELADEIDKQYVININKMFSEEQAAQIKASMGKTTWQAIHIPTIVSRTTDGAQTSRWAAMQIGMSFISAYAMCAGEAAVADLSFAAKHAALVSMGEMLP...............
D7E8X7_METEZ/15-284                ..ERKFTQEFGD.NKQSGgEITDKKTEY-QRMGVAQSPRKMEMLKAGQEL.SKKR..GLVGYNPDL-HAgGVQLGQRALTPSYLSGT.DMLTEMDDLHYVNNAAMQQMWDDIRRTCIVGMDSAHETLEKRLGIEVTPETINHYLEVLNHAIPGGAVVQEHMVETHPGLTEDCYVKIFTGDDDLADEIDDQFLIDIDKEFPEDQAQQLKESIGKTTWQVAHIPTVVSRTTDGGQTRRWMAMQLGMSFINAYHMCAGEAAVADLSYAAKHASVINMGEMLP...............
F6BBJ2_METIK/5-270                 ..KKLFLKALRE.KFE-E.DPKEKYTKFYVFGGWKQSARKREFYEYAQKI.AKER..GIPGYNPDI---.GVPLGQRKLMTYKISGT.DAFVEGDDLHFCNNAAIQQLVDDIKRTVIVGMDTAHAVLEKRLGVEVTPETINEYMETINHALPGGAVVQEHMVEVHPGLVWDCYAKIFTGNDELADEIDKRFLIDINKEFPEEQAEMLKRYIGNRTYQVSRVPTLVVRCCDGATVARWSAMQIGMSFITAYKLCAGEAAIADFSYAAKHADVIQMGTLLP...............
F0TCV5_METLA/5-270                 ..KKLFLKALKN.KFN-E.DPNEHYTDYYCYGGWEQSPRKKEFNEFSKKL.EEER..GLPGYNPDI---.GVPLGQRKLMSYKVSGT.DSYVEGDDLHFLNNSAIQQLSDDIKRTIIVGMDTAHAVLEKRLGVEVTPETINNYMETINHALPGGAVVQEHMVEVHPGLVGDCYAKLFSGDDDLIDELDSRFLVDINKEFPEEQAEQLKDYIGKKTYQISRVPTMVVRACDGGTVSRWSAMQIGMSFISAYKLCAGEAAIADFSYAAKHADVISMGSILP...............
Q2FSN0_METHJ/8-277                 ..QKLFLKALKT.KFE-G.DVADTKTGFYNFGGLNQSPRKKEFMEASKKV.ELRR..GISMYDPNRCHLgGLPMGQRQLMTYEVSGT.GTFVEGDDLHFVNNPAMQQMWDDIRRTIIVNMDLAHQTLQKRLGKEITPETINEYLHILNHAMPGGAVVQEHMVETHPSVVDDCYVKVFTGDSELADQIEKQFVLDVNKLFPAKQAEQLNEAVGKSLWQAIHIPTIVSRTCDGGTTSRWSAMQIGMSFITAYRMCAGEAAVADLSFAAKHAGVIQMASHLP...............
D5EAD6_METMS/14-284                ev--KFTKEHGTnKMEGG.DITDMRIPYY-RLGVDQNPRKLEMKKVGKDI.AEKR..GLAGYNP-MMHCgGIPLGQRALTPSFISGNdDMMVENDDLHYVNNAAMQQMWDDIRRTCIVGMDMAHETLEKRLSIEVTPETINHYLEVLNHALPGGAVVQEHMVESHPALVDDCYVKIFTGDDELADEIDDQFLIDIDKQFPAEQAEQLKASIGNTTWQAAHIPTIVSRTTDGGQTTRWTAMQIGMSYIAAYGMCAGEAAVADLSYAAKHAGVVNMGDMLP...............
#=GC SS_cons                       .H-HCCHHCCH-.S-T-TTBSEES-S-GGGGGCHHHHHHHHHHHHHHHHH.S---..CCSSSSSS-SS-.EBCCCTTCEECCGCCGG.GHHHHHHHHHHHCCCCEEECCCHHHHHHCCHHH--HHHHHHHHHHHHHHCCCTTTS-TT-SS--TTTGCCSCCEEEECECCHHCCCTCCGCGGCHHHCHHCHHHHHHHHHHCHECEEEEEECHHHHHCHHCHCCHHHHHHHHHHHHHHHCHTTS-TTHHHHHHHHHCCCCCCCE-SC-XBXXXXXXXXXXX...............
#=GC seq_cons                      ..pKLFlcALKc.KFp.E.DspscpTpFYpasGhcQSsRKpEFhctuccl.tccR..GIshYNP-h....GlPLGQRpLMsYplSGT.DsaVEGDDLHFVNNAAMQQhWDDIRRTVIVGhDhAHtsLEKRLGhEVTPETINcYLEslNHAhPGuAVVQEHMVETHPuLVsDCYVKlFTGDDELADEIDppFlIDINK.FPc-QAEpLKsulGKshaQsl+lPTlVuRsCDGGTTSRWSAMQIGMSFIuAY+hCAGEAAlADhSYAAKHAsVIpMGshLP...............
//
DBGET integrated database retrieval system